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Dissertations / Theses on the topic 'Lipid-Based Delivery'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

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1

Jørgensen, Lene. "Lipid based drug delivery systems for parenteral delivery of proteins /." Cph. : Department of Pharmaceutics, the Danish University of Pharmaceutical Sciences, 2004. http://www.dfh.dk/phd/defences/lenejoergensen.htm.

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2

Mok, Kenneth W. C. "Characterization of lipid-based DNA delivery systems." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp02/NQ34590.pdf.

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3

Zhang, Mengzi. "DEVELOPMENTS OF LIPID-BASED NANOPARTICLES FOR THERAPEUTIC DRUG DELIVERY." The Ohio State University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=osu1417025932.

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4

Brinkmann, Joscha [Verfasser]. "Thermodynamics of Lipid-Based Drug Delivery Systems / Joscha Brinkmann." München : Verlag Dr. Hut, 2021. http://d-nb.info/1238423043/34.

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5

Mohamed, Noor Norhayati. "Lipid-based nanoparticles for topical delivery of hair growth therapeutic molecules." Thesis, University College London (University of London), 2017. http://discovery.ucl.ac.uk/10024622/.

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INTRODUCTION: Androgenic alopecia (AA) patients usually have high levels of dihydrotestosterone on their balding scalp area. Currently, dutasteride (DST) is given orally and has systemic adverse effects; diminished sexual desire, increased depression and ejaculation disorder. Topical administration of DST is an appropriate drug-delivery strategy with the potential to reduce systemic side effect, skin irritation and cytotoxicity effects. MATERIALS AND METHOD: Chitosan oligomer (CSO) conjugated with stearic acid (SA) or lauric acid (LA) was synthesised and characterised. Dutasteride-loaded nanos

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6

Solomon, Linda Joy. "Lipid-based formulations for oral delivery of poorly water-soluble drugs." Thesis, University of Bath, 1998. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.263231.

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7

Pan, Xiaogang. "Design and evaluation of lipid based delivery systems for delivery of small molecules and macro-molecular nucleotides based therapeutic agents." Columbus, Ohio : Ohio State University, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1164679618.

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8

Cheng, Xinwei. "Development of a Lipid Nanoparticle-based Antisense Delivery Platform for Cancer Therapy." The Ohio State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=osu154323360801958.

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9

Lam, Angela Man Iu. "Influence of calcium on the transfection properties of lipid-based gene delivery systems." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/NQ61130.pdf.

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10

Jarzębińska, Anita [Verfasser], and Ernst [Akademischer Betreuer] Wagner. "Lipid-based delivery system for chemically modified mRNA / Anita Jarzębińska ; Betreuer: Ernst Wagner." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2017. http://d-nb.info/1136270884/34.

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11

Grove, Mette. "Development and characterisation of lipid-based formulations for oral delivery of poorly soluble drug substances /." Cph. : The Danish University of Pharmaceutical Sciences, Department of Pharmaceutics and Analytical Chemistry, 2006. http://www.dfuni.dk/index.php/Mette_Grove/3071/0/.

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12

Brody, Leigh. "Design, synthesis and biological evaluation of novel lipid-based nanoparticle delivery system for metabolic re-engineering." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/14406.

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Dietary supplementation with fibre has been shown to ameliorate features of the metabolic syndrome and inhibit malignant growth in certain types of cancer. These effects have been linked to short-chain fatty acids (SCFA), mostly acetate. However, the ubiquitous role of SCFAs in metabolism, combined with a short tissue half-life and the non-targeted nature of oral and peripheral administrations make achieving phenotypically relevant levels of SCFA by standard delivery techniques challenging and limit their therapeutic potential. Liposomal encapsulation of a therapeutic agent overcomes these iss

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13

Kleemann, Elke. "Polyethylenimine- and lipid-based nanoparticles as gene and drug delivery systems for aerosol therapy to the lung." [S.l.] : [s.n.], 2005. http://archiv.ub.uni-marburg.de/diss/z2005/0363/.

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14

Helena, (nee Slabbert) Chrizaan. "Formulation, characterization and cellular toxicity of lipid based drug delivery systems for mefloquin / Chrizaan Helena (nee Slabbert)." Thesis, North-West University, 2011. http://hdl.handle.net/10394/8433.

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Malaria affects millions of people annually especially in third world countries. Increase in resistance and limited research being conducted adds to the global burden of malaria. Mefloquine, known for unwanted adverse reactions and neurotoxicity, is highly lipophilic and is still used as treatment and prophylaxis. Lipid drug delivery systems are commonly used to increase solubility and efficacy and decrease toxicity. The most generally used lipid drug delivery system is liposomes. The lipid bilayer structure varying in size from 25 nm to 100 μm can entrap both hydrophilic and lipophilic compou

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15

Varanasi, Ramya. "Advancing in-vitro blood-brain barrier models using lipid-based nanoparticles as a strategy for drug delivery." Thesis, The University of Sydney, 2020. https://hdl.handle.net/2123/25558.

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Introduction: The survival rate of neurological diseases such as brain cancer has remained poor at 1% over the last 30 years despite improvements in technology and novel medicines entering the market. The key obstacle in the treatment of any neurological disease is the blood brain barrier (BBB), a restrictive barrier which ensures the homeostasis of the central nervous system. Developments in lipid-based nanoparticles have presented the opportunity to deliver medicine across the BBB due to their size and ability to tune the ideal properties required to cross. By using human physio-mimicking mo

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16

Gujrati, Maneesh. "Development of a Multifunctional Cationic Lipid-Based siRNA Delivery System for the Treatment of Triple-Negative Breast Cancer." Case Western Reserve University School of Graduate Studies / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=case1432742230.

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17

Song, Lin. "STUDIES OF SOLUBILIZATION OF POORLY WATER-SOLUBLE DRUGS DURING IN VITRO LIPOLYSIS OF A MODEL LIPID-BASED DRUG DELIVERY SYSTEM AND IN MIXED MICELLES." UKnowledge, 2011. http://uknowledge.uky.edu/pharmacy_etds/1.

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Lipid-based drug delivery systems (LBDDSs) are becoming an increasingly popular approach to improve the oral absorption of poorly-water soluble drugs. Several possible mechanisms have been proposed to explain the means by which LBDDSs act in vivo to enhance absorption. The goal of the current dissertation is to provide a better understanding of one proposed mechanism; the capability of lipoidal components in LBDDS formulations to create and maintain a drug in a supersaturated state under simulated GI conditions. Moreover, molecular details of equilibrium solubilization of a drug in a series of

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18

Schwab, Martin. "Degradation of lipid based drug delivery systems and characterization of semi-synthetic spider silk proteins for the application in pharmaceutical technology." Diss., Ludwig-Maximilians-Universität München, 2009. http://nbn-resolving.de/urn:nbn:de:bvb:19-165238.

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19

Lu, Yaowei. "Multicompartmental lipid-based Janus nanoparticles : influence of different amphiphilic starting materials on their formation mechanisms and their suitability as drug delivery vehicles." Electronic Thesis or Diss., université Paris-Saclay, 2025. http://www.theses.fr/2025UPASQ009.

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Les nanoparticules Janus (JNP) asymétriques innovantes à base de lipides développées à l'Institut Galien peuvent servir de nouveaux vecteurs de délivrance de médicaments ou de transporteur d'agents diagnostiques dans le domaine des nanotechnologies. Pour obtenir ce type de particules anisotropes, différentes matières premières (phospholipides et tensioactifs à base de PEG courts ou dérivés amphiphiles de cyclodextrines) et méthodes de préparation (homogénéisation haute pression à chaud ou nanoprécipitation) ont été comparées. Ensuite, nous avons essayé d'optimiser ces JNP, en termes à la fois

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20

MINNELLI, CRISTINA. "Natural and Functionalized Molecules with Antioxidant and Scavenging Activity as Components of Innovative Lipid-based Artificial Tears." Doctoral thesis, Università Politecnica delle Marche, 2019. http://hdl.handle.net/11566/263630.

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Le principali forme farmaceutiche per uso oftalmico sono rappresentate dai colliri grazie alla loro semplicità di preparazione, sterilizzazione e somministrazione. Tuttavia, i colliri presentano una bassa biodisponibilità di circa il 5%. Ottimi risultati si sono ottenuti con l’utilizzo di sistemi di veicolazione di farmaci a base lipidica caratterizzati da elevata biocompatibilità. La nostra attenzione è stata rivolta all’utilizzo di due diverse molecole con potente potenziale antiossidante, l’Epigallocatechina-3-gallato (EGCG) e l’Edaravone, le quali hanno dimostrato la loro efficacia nel tra

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21

Schwab, Martin [Verfasser], and Gerhard [Akademischer Betreuer] Winter. "Degradation of lipid based drug delivery systems and characterization of semi-synthetic spider silk proteins for the application in pharmaceutical technology / Martin Schwab. Betreuer: Gerhard Winter." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2014. http://d-nb.info/1046785257/34.

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22

Klein, Sandra Verfasser], Karsten [Akademischer Betreuer] [Mäder, Markus [Akademischer Betreuer] Pietzsch, and Thomas [Akademischer Betreuer] Rades. "In vitro lipolysis assay as a prognostic tool for the development of lipid based drug delivery systems / Sandra Klein. Betreuer: Karsten Mäder ; Markus Pietzsch ; Thomas Rades." Halle, Saale : Universitäts- und Landesbibliothek Sachsen-Anhalt, 2013. http://d-nb.info/1031189815/34.

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23

Cao, Yichen. "APPLICATION OF LINEAR FREE ENERGY RELATIONSHIPS IN THE PREDICTION OF TRIGLYCERIDE/WATER PARTITION COEFFICIENTS AND LIPID BILAYER PERMEABILITY COEFFICIENTS OF SMALL ORGANIC MOLECULES AND PEPTIDES." UKnowledge, 2008. http://uknowledge.uky.edu/gradschool_diss/655.

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Computational methods such as linear free energy relationships (LFERs) offer a useful high-throughput solution to quickly evaluate drug developability, e.g. membrane permeability, organic solvent/water partition coefficients, and solubility. LFERs typically assume the contribution of structural components/functional groups to the overall properties of a given molecule to be constant and independent. This dissertation describes a series of studies in which linear free energy relationships were developed to predict solvation of small organic molecules in lipid formulations, specifically, triglyc

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24

Terp, Megan Cavanaugh. "Improved Nanoparticle Preparation and Delivery Technology for DOTAP and Oligonucleotide Based Lipoplexes." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1338301430.

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25

Carradori, Dario. "Novel nanoparticle-based drug delivery system for neural stem cell targeting and differentiation." Thesis, Angers, 2017. http://www.theses.fr/2017ANGE0056/document.

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Les cellules souches neurales (CSNs) se situent dans des régions spécifiques du système nerveux central qui sont appelées niches. Ces cellules sont capables de se répliquer ou se différentier en cellules neurales spécialisées (neurones, astrocytes et oligodendrocytes). C’est grâce à cette propriété de différentiation que les CSNs sont étudiées comme thérapie chez les patients atteints d’une maladie neurodégénérative. En effet, elles pourraient remplacer les cellules neurales altérées et ainsi restaurer les fonctions neurologiques. De nombreuses approches ont été développées afin de stimuler la

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26

Attia, Mohamed. "Contrast agent based on nano-emulsion for targeted biomedical imaging." Thesis, Strasbourg, 2016. http://www.theses.fr/2016STRAF043.

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Les agents d’imagerie aux rayons X sont essentiels en combinaison avec la tomodensitométrie pour améliorer le contraste de manière à permettre la visualisation complète des vaisseaux sanguins et de fournir l'information structurelle et fonctionnelle de lésions permettant la détection d'une tumeur. Ces outils fondamentaux permettent également de faire la distinction entre les cellules et les agents pathogènes sains. Les agents de contraste aux rayons X commercialisés sont limités dans leur succès dans le cas du Fenestra® VC par le temps court de circulation dans le sang et celui qui est lié à l

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27

Li, Shuliang. "Lipid- and polymer-based drug delivery vehicles." 2006. http://etd.nd.edu/ETD-db/theses/available/etd-04012006-121707/.

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Thesis (Ph. D.)--University of Notre Dame, 2006.<br>Thesis directed by Andre F. Palmer for the Department of Chemical and Biomolecular Engineering. "April 2006." Includes bibliographical references (leaves 137-152).

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28

Yanasarn, Nijaporn. "Lipid based nanocarriers for chemotherapeutic drug docetaxel and vaccine delivery." Thesis, 2011. http://hdl.handle.net/1957/23014.

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Nanoscale drug delivery systems have a great impact in current medical field. These carriers have the potential to improve the efficacy and reduce the toxicity of various medicinal products. A broad variety of different lipid based carriers had been developed and used as delivery systems in the past decades. This dissertation focused on the development of solid lipid nanoparticles (SLN) as delivery systems for a chemotherapeutic agent, docetaxel, and the use of liposomes as a carrier for recombinant protein vaccines. Docetaxel is a potent anticancer drug. However, there continues to be a need

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29

Pereira, Telmo Galvão. "Development of new gene delivery carriers based on lipid nanoparticles." Master's thesis, 2017. http://hdl.handle.net/10362/28739.

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Gene therapy is a potential strategy for treating numerous gene-associated human diseases. The main constrain for the successful application of gene-based therapy is dependent on the efficient gene delivery system, virus being so far, the most effective. However, this delivery system can have oncogenic and immunogenic effects, and induce inflammatory responses. Thus, nanoparticulate non-viral vectors have been developed based on lipid and polymers overcoming some of these concerns, besides having safety advantages. Among these, solid lipid nanoparticles (SLNs) are of particular relevance due t

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30

Ferreira, Inês Soares. "Lipid based nanocarriers for the delivery of the bioactive compound resveratrol." Master's thesis, 2015. http://hdl.handle.net/1822/41132.

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Dissertação de mestrado em Biofísica e Bionanossistemas<br>Resveratrol is a phenolic compound produced naturally by 72 different plant species, particularly grapevines, pines and legumes1. This compound has powerful anti-oxidant, anti-inflammatory and anti-cancer effects2,3. However, its fast metabolization and reduced solubility in biological fluids impairs its bioavailability. Therefore, it is essential to obtain a suitable carrier to achieve an effective therapy. Liposomes are great candidates as delivery systems since they present high biocompatibility, protection and controlled rele

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31

Waranuch, Neti. "Controlled topical delivery of cyclosporin-A from nonionic lipid-based formulations." 1998. http://catalog.hathitrust.org/api/volumes/oclc/68800309.html.

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32

Granja, Andreia Almeida. "Targeted nanostructured lipid carriers based epigallocatechin gallate delivery system to cancer cellls." Master's thesis, 2016. https://hdl.handle.net/10216/90018.

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33

Granja, Andreia Almeida. "Targeted nanostructured lipid carriers based epigallocatechin gallate delivery system to cancer cellls." Dissertação, 2016. https://hdl.handle.net/10216/90018.

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34

Lam, Angela Man Iu. "Influence of calcium on the transfection properties of lipid-based gene delivery systems." Thesis, 2000. http://hdl.handle.net/2429/13090.

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This thesis is focused on examining the influence of calcium on the transfection potencies and the intracellular processing of two lipid-based gene delivery systems: plasmid DNA-cationic lipid complexes, and stabilized plasmid-lipid particles (SPLP). Results in Chapter 2 demonstrate that calcium can increase the in vitro transfection potency of plasmid DNA-cationic liposome complexes up to 20-fold. The effect is Ca²⁺-specific: other cations such as Mg² and Na⁺ did not give rise to enhanced transfection and the presence of EGTA inhibited the stimulatory effect. It was shown that Ca²⁺ increased

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35

陳葆光. "The Study of Natural Phospholipid as Helper Lipid in Liposome Based Gene Delivery." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/40897906024361326091.

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36

CHI, CHIUNG-JU, and 紀瓊茹. "Research of Lipid-Based Drug Delivery System and Product Strategy - A Case Study of T Company." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/p5k54y.

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碩士<br>輔仁大學<br>科技管理學程碩士在職專班<br>106<br>Longevity are achieved with advancement in the modern medicine technology and healthcare environment, the new challenges faced by modern medicare are chronic disease such as cardiovascular related, age-related and eye related and cancer. Drug delivery technology has become one of the favorable choices with most business potential in the biopharmaceutical technology due to its shorter RD duration, lower cost and higher successful rate. Lipid-based drug delivery system is the most matured of all cutting-edge nano-drug delivery technology and has been successf

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37

Frias, Iúri André Teixeira. "Design, development and characterization of innovative lipid nanocarrier-based epigallocatechin gallate delivery system for preventive and therapeutic supplementation." Master's thesis, 2014. https://repositorio-aberto.up.pt/handle/10216/85936.

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38

Eires, Inês Fernandes. "Relatórios de Estágio e Monografia intitulada “Oral delivery of siRNA-containing lipid-based nanocarriers: challenges and recent advances”." Master's thesis, 2021. http://hdl.handle.net/10316/98985.

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Relatório de Estágio do Mestrado Integrado em Ciências Farmacêuticas apresentado à Faculdade de Farmácia<br>O presente documento é o fruto do trabalho teórico e prático desenvolvido no âmbito da unidade curricular “Estágio”, integrada, no 2º semestre do 5º ano, no plano de estudos do Mestrado Integrado em Ciências Farmacêuticas (MICF) da Faculdade de Farmácia da Universidade de Coimbra (FFUC). A apresentação, discussão pública e aprovação deste trabalho são condições necessárias para a conclusão do curso e consequente obtenção do grau de Mestre em Ciências Farmacêuticas. O documento encontra-s

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39

Silva, Lígia Catarina Gomes da. "A novel multifunctional lipid-based nanoparticle for the delivery of siRNA to cancer cells and the tumor microenvironment." Doctoral thesis, 2012. http://hdl.handle.net/10316/20773.

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40

Frias, Iúri André Teixeira. "Design, development and characterization of innovative lipid nanocarrier-based epigallocatechin gallate delivery system for preventive and therapeutic supplementation." Dissertação, 2014. https://repositorio-aberto.up.pt/handle/10216/85936.

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41

Kleemann, Elke [Verfasser]. "Polyethylenimine- and lipid-based nanoparticles as gene and drug delivery systems for aerosol therapy to the lung / vorgelegt von Elke Kleemann." 2005. http://d-nb.info/975999745/34.

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42

Menicucci, Felicia. "DEVELOPMENT AND CHARACTERIZATION OF GREEN LIPID-BASED NANOVECTORS FOR AGRICULTURAL APPLICATIONS SVILUPPO E CARATTERIZZAZIONE DI NANOVETTORI LIPIDICI “VERDI” PER APPLICAZIONI AGRONOMICHE." Doctoral thesis, 2020. http://hdl.handle.net/2158/1218504.

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Nanotechnologies include a wide range of devices of nanometer scale size, which find application in many different fields, such as medicine, aerospace and energy production, to name but a few. Among these, lipid-based nanoparticles have been the longest-studied nanocarriers since they are the least toxic for in vivo applications. The use of nanotechnology in agriculture is relatively new, especially dealing with plant protection and production. Since a transition from an intensive farming based on the massive use of pesticides and conventional phytochemicals, towards a more sustainable one is

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43

Costa, Pedro Miguel Coutinho da. "MicroRNAs as molecular targets for non-viral gene therapy of glioblastoma: development of a lipid-based nanosystem for nucleic acid delivery to brain tumor cells." Doctoral thesis, 2013. http://hdl.handle.net/10316/23792.

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Tese de doutoramento em Bioquimica, na especialidade de Tecnologia Bioquimica, apresentada à Faculdade de Ciências e Tecnologia da Universidade de Coimbra.<br>Glioblastoma (GBM) is the most common and aggressive primary brain tumor associated with a high degree of mortality. Despite the recent advances in cancer therapy, GBM almost always recurs and patient survival remains under the year mark, thus emphasizing the need for new and effective therapeutic strategies, as well as a better understanding of the molecular alterations that occur in this malignancy. The development of successful GBM th

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44

Cardoso, Ana Luísa Colaço. "Gene silencing as a promising strategy for neuroprotection : on the development of a lipid-based system for the delivery of siRNAs to he central nervous system." Doctoral thesis, 2008. http://hdl.handle.net/10316/7447.

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45

Guru, Raja V. "Novel Redox Responsive Cationic Lipids, Lipopolymers, Glycolipids And Phospholipid-Cationic Lipid Mixtures : Syntheses, Aggregation And Gene Transfection Properties." Thesis, 2014. http://etd.iisc.ac.in/handle/2005/2979.

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The thesis entitled “Novel Redox Responsive Cationic Lipids, Lipopolymers, Glycolipids and Phospholipid-Cationic Lipid Mixtures: Syntheses, Aggregation and Gene Transfection Properties” elucidates the design, synthesis, aggregation and gene transfection properties of novel cholesterol based cationic lipids with ferrocene as the redox moiety, polyethylenimine based ferrocenylated lipopolymers and cholesterol based non-ionic glycolipids. The thesis also discusses the cationic phospholipid-cationic lipid mixtures as superior gene transfection agents. The work has been divided into six cha

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Guru, Raja V. "Novel Redox Responsive Cationic Lipids, Lipopolymers, Glycolipids And Phospholipid-Cationic Lipid Mixtures : Syntheses, Aggregation And Gene Transfection Properties." Thesis, 2014. http://etd.iisc.ernet.in/handle/2005/2979.

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The thesis entitled “Novel Redox Responsive Cationic Lipids, Lipopolymers, Glycolipids and Phospholipid-Cationic Lipid Mixtures: Syntheses, Aggregation and Gene Transfection Properties” elucidates the design, synthesis, aggregation and gene transfection properties of novel cholesterol based cationic lipids with ferrocene as the redox moiety, polyethylenimine based ferrocenylated lipopolymers and cholesterol based non-ionic glycolipids. The thesis also discusses the cationic phospholipid-cationic lipid mixtures as superior gene transfection agents. The work has been divided into six cha

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47

Misra, Santosh Kumar. "Synthesis And Characterization of Cationic Lipids And Carbon Nanomaterials Based Composites for the Delivery Of Bioactive Oligo/Polynucleotides and Drugs In Vitro and In Vivo." Thesis, 2013. http://etd.iisc.ac.in/handle/2005/2805.

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The biggest hurdle in success of gene and drug therapy is designing and preparation of suitable bio-nanomaterials to carry the desired nucleic acid and drug to the targeted site. The work described in the present thesis encompasses two different approaches for the delivery of bioactive oligo/polynucleotides and drugs in vitro and in vivo using either cationic lipids or their nanocomposites with different carbon nanomaterials. The idea of using carriers for oligo/polynucleotides and drugs came into existence because of numerous physiological barriers in pathway of delivery of naked oligo/polynu

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48

Misra, Santosh Kumar. "Synthesis And Characterization of Cationic Lipids And Carbon Nanomaterials Based Composites for the Delivery Of Bioactive Oligo/Polynucleotides and Drugs In Vitro and In Vivo." Thesis, 2013. http://etd.iisc.ernet.in/handle/2005/2805.

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The biggest hurdle in success of gene and drug therapy is designing and preparation of suitable bio-nanomaterials to carry the desired nucleic acid and drug to the targeted site. The work described in the present thesis encompasses two different approaches for the delivery of bioactive oligo/polynucleotides and drugs in vitro and in vivo using either cationic lipids or their nanocomposites with different carbon nanomaterials. The idea of using carriers for oligo/polynucleotides and drugs came into existence because of numerous physiological barriers in pathway of delivery of naked oligo/polynu

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