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Dissertations / Theses on the topic 'Lipid Based Drug Delivery System'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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1

Jørgensen, Lene. "Lipid based drug delivery systems for parenteral delivery of proteins /." Cph. : Department of Pharmaceutics, the Danish University of Pharmaceutical Sciences, 2004. http://www.dfh.dk/phd/defences/lenejoergensen.htm.

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2

Brinkmann, Joscha [Verfasser]. "Thermodynamics of Lipid-Based Drug Delivery Systems / Joscha Brinkmann." München : Verlag Dr. Hut, 2021. http://d-nb.info/1238423043/34.

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3

Pan, Xiaogang. "Design and evaluation of lipid based delivery systems for delivery of small molecules and macro-molecular nucleotides based therapeutic agents." Columbus, Ohio : Ohio State University, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1164679618.

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4

Song, Lin. "STUDIES OF SOLUBILIZATION OF POORLY WATER-SOLUBLE DRUGS DURING IN VITRO LIPOLYSIS OF A MODEL LIPID-BASED DRUG DELIVERY SYSTEM AND IN MIXED MICELLES." UKnowledge, 2011. http://uknowledge.uky.edu/pharmacy_etds/1.

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Lipid-based drug delivery systems (LBDDSs) are becoming an increasingly popular approach to improve the oral absorption of poorly-water soluble drugs. Several possible mechanisms have been proposed to explain the means by which LBDDSs act in vivo to enhance absorption. The goal of the current dissertation is to provide a better understanding of one proposed mechanism; the capability of lipoidal components in LBDDS formulations to create and maintain a drug in a supersaturated state under simulated GI conditions. Moreover, molecular details of equilibrium solubilization of a drug in a series of

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5

Carradori, Dario. "Novel nanoparticle-based drug delivery system for neural stem cell targeting and differentiation." Thesis, Angers, 2017. http://www.theses.fr/2017ANGE0056/document.

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Les cellules souches neurales (CSNs) se situent dans des régions spécifiques du système nerveux central qui sont appelées niches. Ces cellules sont capables de se répliquer ou se différentier en cellules neurales spécialisées (neurones, astrocytes et oligodendrocytes). C’est grâce à cette propriété de différentiation que les CSNs sont étudiées comme thérapie chez les patients atteints d’une maladie neurodégénérative. En effet, elles pourraient remplacer les cellules neurales altérées et ainsi restaurer les fonctions neurologiques. De nombreuses approches ont été développées afin de stimuler la

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6

Kleemann, Elke. "Polyethylenimine- and lipid-based nanoparticles as gene and drug delivery systems for aerosol therapy to the lung." [S.l.] : [s.n.], 2005. http://archiv.ub.uni-marburg.de/diss/z2005/0363/.

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7

Helena, (nee Slabbert) Chrizaan. "Formulation, characterization and cellular toxicity of lipid based drug delivery systems for mefloquin / Chrizaan Helena (nee Slabbert)." Thesis, North-West University, 2011. http://hdl.handle.net/10394/8433.

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Malaria affects millions of people annually especially in third world countries. Increase in resistance and limited research being conducted adds to the global burden of malaria. Mefloquine, known for unwanted adverse reactions and neurotoxicity, is highly lipophilic and is still used as treatment and prophylaxis. Lipid drug delivery systems are commonly used to increase solubility and efficacy and decrease toxicity. The most generally used lipid drug delivery system is liposomes. The lipid bilayer structure varying in size from 25 nm to 100 μm can entrap both hydrophilic and lipophilic compou

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8

Schwab, Martin. "Degradation of lipid based drug delivery systems and characterization of semi-synthetic spider silk proteins for the application in pharmaceutical technology." Diss., Ludwig-Maximilians-Universität München, 2009. http://nbn-resolving.de/urn:nbn:de:bvb:19-165238.

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9

Schwab, Martin [Verfasser], and Gerhard [Akademischer Betreuer] Winter. "Degradation of lipid based drug delivery systems and characterization of semi-synthetic spider silk proteins for the application in pharmaceutical technology / Martin Schwab. Betreuer: Gerhard Winter." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2014. http://d-nb.info/1046785257/34.

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10

Klein, Sandra Verfasser], Karsten [Akademischer Betreuer] [Mäder, Markus [Akademischer Betreuer] Pietzsch, and Thomas [Akademischer Betreuer] Rades. "In vitro lipolysis assay as a prognostic tool for the development of lipid based drug delivery systems / Sandra Klein. Betreuer: Karsten Mäder ; Markus Pietzsch ; Thomas Rades." Halle, Saale : Universitäts- und Landesbibliothek Sachsen-Anhalt, 2013. http://d-nb.info/1031189815/34.

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11

Cao, Yichen. "APPLICATION OF LINEAR FREE ENERGY RELATIONSHIPS IN THE PREDICTION OF TRIGLYCERIDE/WATER PARTITION COEFFICIENTS AND LIPID BILAYER PERMEABILITY COEFFICIENTS OF SMALL ORGANIC MOLECULES AND PEPTIDES." UKnowledge, 2008. http://uknowledge.uky.edu/gradschool_diss/655.

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Computational methods such as linear free energy relationships (LFERs) offer a useful high-throughput solution to quickly evaluate drug developability, e.g. membrane permeability, organic solvent/water partition coefficients, and solubility. LFERs typically assume the contribution of structural components/functional groups to the overall properties of a given molecule to be constant and independent. This dissertation describes a series of studies in which linear free energy relationships were developed to predict solvation of small organic molecules in lipid formulations, specifically, triglyc

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12

Zhang, Mengzi. "DEVELOPMENTS OF LIPID-BASED NANOPARTICLES FOR THERAPEUTIC DRUG DELIVERY." The Ohio State University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=osu1417025932.

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13

Salvage, Jonathan Peter. "A novel phosphorylcholine-based nanoparticulate drug delivery system." Thesis, University of Brighton, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.499068.

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Phosphorylcholine (PC) based materials have been shown to have increased biocompatibility when compared to more established bio-implantable materials. This has been attributed to the ability of PC to mimic the cell lipid bilayer membrane, resulting in reduced protein adhesion and cellular interaction / activation. PC research has previously focused on the areas of contact lens formulation and medical device coating. This project sought to harness the biomimetic properties of PC to develop novel systems for drug delivery, with the emphasis being focused on microparticulate drug delivery.

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14

Roxhed, Niclas. "A Fully Integrated Microneedle-based Transdermal Drug Delivery System." Doctoral thesis, Stockholm : Kungliga Tekniska högskolan, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-4484.

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15

Patel, Meghavi. "Development, Characterization and Evaluation of Solid Lipid Nanoparticles as a Potential Anticancer Drug Delivery System." University of Toledo Health Science Campus / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=mco1352944517.

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16

Grove, Mette. "Development and characterisation of lipid-based formulations for oral delivery of poorly soluble drug substances /." Cph. : The Danish University of Pharmaceutical Sciences, Department of Pharmaceutics and Analytical Chemistry, 2006. http://www.dfuni.dk/index.php/Mette_Grove/3071/0/.

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17

Wong, Ling Wai. "Molecular delivery system based on the nanoporous zeolite microstructures /." View abstract or full-text, 2006. http://library.ust.hk/cgi/db/thesis.pl?BIEN%202006%20WONG.

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18

Svirskis, Darren. "Development of a novel drug delivery system based on conducting polymers." Thesis, University of Auckland, 2010. http://hdl.handle.net/2292/6568.

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Controlled release systems offer advantages over conventional therapies by maintaining drug concentrations at therapeutically desired levels whilst simultaneously improving compliance. Intrinsically Conducting Polymers (ICP) are organic materials that have electrical, magnetic and optical properties usually associated with metals, whilst retaining the advantageous mechanical properties and ease of processing usually associated with polymers. A novel drug delivery system, based on the ICP polypyrrole (PPy), has been developed to provide for the controlled release of risperidone. Due to t

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19

Jarzębińska, Anita [Verfasser], and Ernst [Akademischer Betreuer] Wagner. "Lipid-based delivery system for chemically modified mRNA / Anita Jarzębińska ; Betreuer: Ernst Wagner." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2017. http://d-nb.info/1136270884/34.

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20

Varanasi, Ramya. "Advancing in-vitro blood-brain barrier models using lipid-based nanoparticles as a strategy for drug delivery." Thesis, The University of Sydney, 2020. https://hdl.handle.net/2123/25558.

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Introduction: The survival rate of neurological diseases such as brain cancer has remained poor at 1% over the last 30 years despite improvements in technology and novel medicines entering the market. The key obstacle in the treatment of any neurological disease is the blood brain barrier (BBB), a restrictive barrier which ensures the homeostasis of the central nervous system. Developments in lipid-based nanoparticles have presented the opportunity to deliver medicine across the BBB due to their size and ability to tune the ideal properties required to cross. By using human physio-mimicking mo

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21

KALAJA, ODETA. "Nanoparticles based delivery System of Flavonoids for Cancer Therapy." Doctoral thesis, Università degli Studi di Trieste, 2018. http://hdl.handle.net/11368/2917683.

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Nowadays, cancer remains one of the major public health problem. Although chemotherapeutic drugs efficiently kill cancer cells, these cells can defend themselves from such toxic compounds with a process called cancer multidrug resistance (MDR). Because of unsatisfactory treatment scenario there has been growing interest in the health advantages of using plant-derived compounds for cancer prevention or in the treatment of chemo-resistant cells. Anthocyanidins are a group of pigments belonging to the family of flavonoids present in red-blue fruits and vegetables. Several studies demonstrated tha

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22

Kurniasih, Indah Nurita [Verfasser]. "Nanocarrier System for Drug Delivery Based on Hyperbranched Polyglycerol / Indah Nurita Kurniasih." Berlin : Freie Universität Berlin, 2013. http://d-nb.info/1043957863/34.

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23

Chianello, Giorgio. "Methacrylate based nanogels as drug delivery system and Pickering-Ramsden emulsion stabiliser." Thesis, Queen Mary, University of London, 2016. http://qmro.qmul.ac.uk/xmlui/handle/123456789/24565.

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A novel methacrylate based nanogel system has been designed and developed for drug delivery applications. Methacrylates are optimal tuneable materials in terms of polarity, with combination of hydrophobic and hydrophilic moieties. Synthesis of these nanogels (NGs) was achieved via high dilution radical polymerisation using 2-(tert-butylamino)ethyl methacrylate (tBAEMA) as functional monomer, methacrylic acid (MAA) or ethylene glycol methyl ether methacrylate (EGMMA) as co-monomer and N,N'-methylenebis(acrylamide) (MBA) as cross-linker. Fabricated nanoparticles (NPs) were shown to possess water

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24

Nahak, Prasant. "Physicochemical studies on lipidic components with special reference to monolayer, bilayer,and solid lipid nanoparticle." Thesis, University of North Bengal, 2017. http://ir.nbu.ac.in/handle/123456789/3967.

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25

Misirlis, Dimitrios. "Development of a novel drug delivery system based on polymeric, thermoresponsive, hydrogel nanoparticles /." [S.l.] : [s.n.], 2005. http://library.epfl.ch/theses/?nr=3362.

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26

Flinn, Nicholas Sean. "A lipidic amino acid based system for peptide delivery and enhancing peptide immunogenicity." Thesis, University College London (University of London), 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.244682.

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27

Parsian, Ava. "Simvastatin Encapsulation in Alginate-Based Microspheres." Thesis, Université d'Ottawa / University of Ottawa, 2016. http://hdl.handle.net/10393/34439.

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Despite the great success of hip implant surgeries, wear particle-induced implant aseptic loosening still limits the implant longevity. Simvastatin, an FDA-approved cholesterol lowering statin, is a promising drug candidate for the treatment of implant aseptic loosening due to its anti-inflammatory properties as well as its ability to stimulate bone growth and inhibit bone resorption. In addition, alginate microspheres have been used extensively in drug delivery applications because of alginate properties, including biocompatibility and gelation in mild conditions. However, the hydrophobicity

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28

Horie, Rie. "Treatment of inner ear disorders using nano/micro particles based on drug delivery system." Kyoto University, 2011. http://hdl.handle.net/2433/142087.

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29

Brody, Leigh. "Design, synthesis and biological evaluation of novel lipid-based nanoparticle delivery system for metabolic re-engineering." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/14406.

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Dietary supplementation with fibre has been shown to ameliorate features of the metabolic syndrome and inhibit malignant growth in certain types of cancer. These effects have been linked to short-chain fatty acids (SCFA), mostly acetate. However, the ubiquitous role of SCFAs in metabolism, combined with a short tissue half-life and the non-targeted nature of oral and peripheral administrations make achieving phenotypically relevant levels of SCFA by standard delivery techniques challenging and limit their therapeutic potential. Liposomal encapsulation of a therapeutic agent overcomes these iss

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30

Rattanakiat, Sakulrat. "Development of novel DNA-based nanosized drug delivery system using DNA containing unmethylated CpG dinucleotides." 京都大学 (Kyoto University), 2009. http://hdl.handle.net/2433/126606.

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31

Samia, Anna Cristina S. "Design and control of the superparamagnetic properties of cobalt-based spinel ferrite nanoparticles." Diss., Georgia Institute of Technology, 2002. http://hdl.handle.net/1853/31048.

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32

Ram, Rakhyani Anil. "Design of efficient wireless power-transfer system and piezoelectric transducer for sonoporation-based drug delivery implants." Thesis, University of British Columbia, 2010. http://hdl.handle.net/2429/25967.

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Implantable devices are becoming popular in health and medical applications. In particular, localized and controlled drug release systems have gained clinical relevance in the treatment of many diseases. The power requirement for sonoporation-based systems is comparatively higher than that of other implantable devices. Efficient wireless power delivery and efficient small ultrasound transducer with low aspect ratio (G = length/thickness) is required to obtain high power transfer efficiency for implantable sonoporation based system. To provide power wirelessly to implantable device, resonance-b

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33

Lu, Yaowei. "Multicompartmental lipid-based Janus nanoparticles : influence of different amphiphilic starting materials on their formation mechanisms and their suitability as drug delivery vehicles." Electronic Thesis or Diss., université Paris-Saclay, 2025. http://www.theses.fr/2025UPASQ009.

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Les nanoparticules Janus (JNP) asymétriques innovantes à base de lipides développées à l'Institut Galien peuvent servir de nouveaux vecteurs de délivrance de médicaments ou de transporteur d'agents diagnostiques dans le domaine des nanotechnologies. Pour obtenir ce type de particules anisotropes, différentes matières premières (phospholipides et tensioactifs à base de PEG courts ou dérivés amphiphiles de cyclodextrines) et méthodes de préparation (homogénéisation haute pression à chaud ou nanoprécipitation) ont été comparées. Ensuite, nous avons essayé d'optimiser ces JNP, en termes à la fois

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34

Gujrati, Maneesh. "Development of a Multifunctional Cationic Lipid-Based siRNA Delivery System for the Treatment of Triple-Negative Breast Cancer." Case Western Reserve University School of Graduate Studies / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=case1432742230.

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35

Thovhogi, Ntevheleni. "Development of nanotechnology-based drug delivery and imaging system to the white adipose tissue vasculature using Wistar Rat Model." University of the Western Cape, 2013. http://hdl.handle.net/11394/4753.

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Philosophiae Doctor - PhD<br>Obesity is a complex metabolic disease of excessive fat accumulation. It is a worldwide epidemic affecting billions of people and its pharmacological management is hampered by drug toxicity and undesirable side effects. Therefore, a need still exists for the development of safe medication for treatment of obesity. Nanotechnology involves the use of small particles at atomic and molecular scale. It has application in medical diagnostics, drug delivery and molecular imaging. Various nanoparticles (NPs) functionalized with different biomolecules have been successfully

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36

Murata, Yuki. "Design and Preparation of Gelatin-Based Carriers for Imaging Probes to Visualize Cell Functions." Doctoral thesis, Kyoto University, 2021. http://hdl.handle.net/2433/263622.

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37

CALANDRO, PIERPAOLO. "Development of liposome-based drug delivery system to improve drug-like properties and anticancer activity of tyrosine kinase inhibitors with pyrazolo [3,4-d] pyrimidine structure." Doctoral thesis, Università degli studi di Siena, 2017. http://hdl.handle.net/11365/1004793.

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Cancer is a multifactorial disease whose causes are still unknown. Frequently, mutations in several genes play an important role in cellular growth processes and, based on their specific roles, they are usually distinguished in proto-oncogenes and oncosuppressors. One of the most studied oncogenes is c-Src, encoding for a non-receptor tyrosine kinase protein that plays a multitude of roles in cell signalling. The activation of c-Src is involved in the control of many functions, including cell adhesion, growth, movement, and differentiation by a different set of cell surface receptors. c-Src is

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38

MINNELLI, CRISTINA. "Natural and Functionalized Molecules with Antioxidant and Scavenging Activity as Components of Innovative Lipid-based Artificial Tears." Doctoral thesis, Università Politecnica delle Marche, 2019. http://hdl.handle.net/11566/263630.

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Le principali forme farmaceutiche per uso oftalmico sono rappresentate dai colliri grazie alla loro semplicità di preparazione, sterilizzazione e somministrazione. Tuttavia, i colliri presentano una bassa biodisponibilità di circa il 5%. Ottimi risultati si sono ottenuti con l’utilizzo di sistemi di veicolazione di farmaci a base lipidica caratterizzati da elevata biocompatibilità. La nostra attenzione è stata rivolta all’utilizzo di due diverse molecole con potente potenziale antiossidante, l’Epigallocatechina-3-gallato (EGCG) e l’Edaravone, le quali hanno dimostrato la loro efficacia nel tra

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39

Kreß, Sebastian [Verfasser], Heike [Gutachter] Walles, and Georg [Gutachter] Krohne. "Development and proof of concept of a biological vascularized cell‐based drug delivery system / Sebastian Kreß ; Gutachter: Heike Walles, Georg Krohne." Würzburg : Universität Würzburg, 2019. http://d-nb.info/1182230415/34.

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40

Mu, Xiaohong. "In vitro characterisation of food effects on in vivo performance of a heterodisperse polysaccharide-based controlled drug delivery system in gastrointestinal tract." Thesis, University of Bath, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.340927.

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41

Lahori, Deeksha. "Combination of nitric oxide and polymer based drug delivery system to improve the effectiveness of a peptide inhibitor in cancer therapy outcomes." Thesis, University of Sydney, 2020. https://hdl.handle.net/2123/24311.

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The recent development in the field of nanotechnology offers the opportunity to alter the pharmacokinetic profiles of drugs, reducing off-target toxicity and improving therapeutic index, and ultimately patient outcome. This study aims to use a biodegradable and biocompatible material which is a modified form of the glucose polymer ‘dextran’. Aldehyde-functionalised dextran is the oxidised form of dextran to introduce aldehyde functionality for stably chemical loading therapeutic agents for its potential application in cancer treatment. Cancer is a heterogeneous disease caused by the progressiv

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42

Packhäuser, Claudia. "Amine modified branched polyesters as tools for nano carrier based drug delivery systems in situ forming parenteral depots & aerosol therapy to the lung." Göttingen Sierke, 2006.

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43

Haraszti, Reka A. "Engineered Exosomes for Delivery of Therapeutic siRNAs to Neurons." eScholarship@UMMS, 2018. https://escholarship.umassmed.edu/gsbs_diss/971.

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Extracellular vesicles (EVs), exosomes and microvesicles, transfer endogenous RNAs between neurons over short and long distances. We have explored EVs for siRNA delivery to brain. (1) We optimized siRNA chemical modifications and siRNA conjugation to lipids for EV-mediated delivery. (2) We developed a GMP-compatible, scalable method to manufacture active EVs in bulk. (3) We characterized lipid and protein content of EVs in detail. (4) We established how protein and lipid composition relates to siRNA delivering activity of EVs, and we reverse engineered natural exosomes (small EVs) into artific

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44

ANGELLOTTI, Giuseppe. "Sviluppo di spugne bioerodibili multifunzionali per la promozione di processi riparativi mediante il rilascio controllato di agenti antibiotici e antiossidanti. Utilizzo in chirurgia orale." Doctoral thesis, Università degli Studi di Palermo, 2023. https://hdl.handle.net/10447/580944.

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La salute delle strutture molli e dure del cavo orale è essenziale non solo per preservare le funzioni ad esse direttamente associate, ma anche per promuovere la salute generale dell’organismo. Tra le problematiche di maggiore interesse clinico a carico della cavità orale ritroviamo: i) le complicazioni post-operatorie che possono verificarsi a seguito di comuni avulsioni dentali che, se non trattate tempestivamente, possono sfociare in gravi parodontiti; ii) i fenomeni di osteonecrosi a carico di mascella e mandibola associate a trattamenti farmacologici nonché alla radioterapia; iii) il carc

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Attia, Mohamed. "Contrast agent based on nano-emulsion for targeted biomedical imaging." Thesis, Strasbourg, 2016. http://www.theses.fr/2016STRAF043.

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Les agents d’imagerie aux rayons X sont essentiels en combinaison avec la tomodensitométrie pour améliorer le contraste de manière à permettre la visualisation complète des vaisseaux sanguins et de fournir l'information structurelle et fonctionnelle de lésions permettant la détection d'une tumeur. Ces outils fondamentaux permettent également de faire la distinction entre les cellules et les agents pathogènes sains. Les agents de contraste aux rayons X commercialisés sont limités dans leur succès dans le cas du Fenestra® VC par le temps court de circulation dans le sang et celui qui est lié à l

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46

Liu, Juan. "Nouveaux systèmes nanométriques et ph dépendant pour le transport de médicaments contre les phénomènes de résistances." Thesis, Aix-Marseille, 2016. http://www.theses.fr/2016AIXM4072.

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La résistance aux médicaments constitue un obstacle majeur pour le traitement du cancer. Les systèmes nanoparticulaires de délivrance de médicaments (nanoparticule drug delivery system, NDDS) sont pressentis pour apporter un nouvel espoir dans le traitement du cancer afin de surmonter la résistance aux médicaments en délivrant spécifiquement l’agent anticancéreux dans la lésion tumorale par effet EPR. Cela aura pour effet d’augmenter la concentration locale en médicaments et par conséquent d’améliorer l'efficacité thérapeutique tout en épargnant les tissus sains afin d'éviter les effets second

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47

Liu, Juan. "Nouveaux systèmes nanométriques et ph dépendant pour le transport de médicaments contre les phénomènes de résistances." Electronic Thesis or Diss., Aix-Marseille, 2016. http://www.theses.fr/2016AIXM4072.

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La résistance aux médicaments constitue un obstacle majeur pour le traitement du cancer. Les systèmes nanoparticulaires de délivrance de médicaments (nanoparticule drug delivery system, NDDS) sont pressentis pour apporter un nouvel espoir dans le traitement du cancer afin de surmonter la résistance aux médicaments en délivrant spécifiquement l’agent anticancéreux dans la lésion tumorale par effet EPR. Cela aura pour effet d’augmenter la concentration locale en médicaments et par conséquent d’améliorer l'efficacité thérapeutique tout en épargnant les tissus sains afin d'éviter les effets second

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48

Lemaire, Gaelle. "Elaboration de Nanoparticules hybrides et multiphasées innovantes pour la délivrance de principe actif." Thesis, Angers, 2017. http://www.theses.fr/2017ANGE0054.

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Les limites des nanovecteurs commerciaux ou actuellement en développement ont motivé l’élaboration de nouvelles nanoparticules mésoporeuses de silice (MSNP), hybrides et multiphasées, pour le contrôle de la délivrance d’actifs à application théranostique. Ainsi, de nouvelles MSNP ont été conçues pour la pénétration intracellulaire (diamètre entre 30 et 60 nm, taille des pores de 2,8 nm). Afin de les rendre hémocompatibles et de contrôler la cinétique de délivrance de principes actifs encapsulés, ces MSNP ont été enrobées d’une bicouche lipidique (MSNP+@SLB-). La composition lipidique s’inspire

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49

Lajous, Hélène. "Cisplatine : une vieille molécule pour de nouveaux défis. : développement d’une prodrogue macromoléculaire multifonctionnelle applicable au traitement local du glioblastome." Thesis, Angers, 2018. http://www.theses.fr/2018ANGE0046/document.

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Le glioblastome constitue la tumeur primitive maligne la plus fréquente et la plus agressive du système nerveux central, caractérisée par un pronostic sombre. L’infusion locale dans le parenchyme cérébral du cisplatine a présenté des résultats encourageants sur des modèles précliniques. La nanovectorisation permet de concentrer l’efficacité thérapeutique d’agents anticancéreux à leur cible. Leur fonctionnalisation par des unités d’imagerie offre la possibilité de suivre de façon non invasive par imagerie par résonance magnétique (IRM) leur biodistribution au sein du tissu lésé. Dans cette opti

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Papežíková, Hana. "Potenciál využití semi-interpenetrovaných polymerních sítí na bázi poly-HEMA v moderních nosičových systémech." Master's thesis, Vysoké učení technické v Brně. Fakulta chemická, 2021. http://www.nusl.cz/ntk/nusl-449370.

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