Academic literature on the topic 'Lipid Based Nanoparticles'

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Journal articles on the topic "Lipid Based Nanoparticles"

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Korzun, Tetiana, Abraham S. Moses, Parham Diba, et al. "From Bench to Bedside: Implications of Lipid Nanoparticle Carrier Reactogenicity for Advancing Nucleic Acid Therapeutics." Pharmaceuticals 16, no. 8 (2023): 1088. http://dx.doi.org/10.3390/ph16081088.

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In biomedical applications, nanomaterial-based delivery vehicles, such as lipid nanoparticles, have emerged as promising instruments for improving the solubility, stability, and encapsulation of various payloads. This article provides a formal review focusing on the reactogenicity of empty lipid nanoparticles used as delivery vehicles, specifically emphasizing their application in mRNA-based therapies. Reactogenicity refers to the adverse immune responses triggered by xenobiotics, including administered lipid nanoparticles, which can lead to undesirable therapeutic outcomes. The key components
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Jaswinder, Singh *. "LIPID NANOPARTICULATE DRUG DELIVERY SYSTEMS." Journal of Pharma Research 8, no. 8 (2019): 557–63. https://doi.org/10.5281/zenodo.3374087.

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<strong><em>ABSTRACT</em></strong> <strong><em>C</em></strong><em>olloidal particles of size range between 10 and 1000 nm are known as nanoparticles. Over the last few years, lipid based drug delivery systems such as solid lipid nanoparticle (SLN) and nanostructured lipid carrier (NLC) and lipid drug conjugate (LDC) have become the most promising drug delivery systems. Each preparation of the lipid based nanoparticles has advantages and disadvantages with respect to specific characteristics. The SLN is an excellent drug delivery system and has extensive prospects in the pharmaceutical field. N
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Jafar, Garnadi, R. Awaludin Nazal N, and Entris Sutrisno. "REVIEW: REVIEW ARTICLE LIPID-BASED NANOTECHNOLOGY." Medical Sains : Jurnal Ilmiah Kefarmasian 9, no. 1 (2024): 189–204. http://dx.doi.org/10.37874/ms.v9i1.1084.

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Nanotechnology is defined as engineering the creation of materials, functions, and devices on the nanometer scale. Nanoscience is increasingly developing and becoming a part of various fields, such as electronics, materials, and biology. Lipid nanoparticles are a major application in nanotechnology. In formulas II and III, smaller results were obtained compared with the other formulas. Based on the results of this study, it can be concluded that the nanostructured lipid carrier system with solid lipid poloxamer and stearic acid with liquid soybean oil lipids obtained good characteristics, and
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Onteru, Sujeevan. "Lipid-based nanoparticles and their recent advances." GSC Advanced Research and Reviews 18, no. 3 (2024): 182–88. https://doi.org/10.5281/zenodo.11217314.

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Lipid-based nanoparticles hold great potential for drug delivery, providing biocompatibility and the ability to encapsulate both hydrophilic and hydrophobic drugs. However, there are certain challenges associated with small molecules, such as leakage and premature release, which can compromise their effectiveness. Despite these challenges, lipid nanoparticles offer advantages in terms of solubility, stability, and targeted delivery, thereby reducing side effects. Additionally, they can be customized for specific molecules, ensuring biocompatibility and biodegradability. While complications may
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Chountoulesi, Maria, Natassa Pippa, Aleksander Forys, Barbara Trzebicka, and Stergios Pispas. "Structure-Based Evaluation of Hybrid Lipid–Polymer Nanoparticles: The Role of the Polymeric Guest." Polymers 16, no. 2 (2024): 290. http://dx.doi.org/10.3390/polym16020290.

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The combination of phospholipids and block-copolymers yields advanced hybrid nanoparticles through the self-assembly process in an aqueous environment. The physicochemical features of the lipid/polymer components, like the lipid–polymer molar ratio, the macromolecular architecture of the block copolymer, the main transition temperature of the phospholipid, as well as the formulation and preparation protocol parameters, are some of the most crucial parameters for the formation of hybrid lipid/polymer vesicles and for the differentiation of their morphology. The morphology, along with other phys
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Olinger, Alexander D., Eric J. Spangler, P. B. Sunil Kumar, and Mohamed Laradji. "Membrane-mediated aggregation of anisotropically curved nanoparticles." Faraday Discussions 186 (2016): 265–75. http://dx.doi.org/10.1039/c5fd00144g.

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Using systematic numerical simulations, we study the self-assembly of elongated curved nanoparticles on lipid vesicles. Our simulations are based on molecular dynamics of a coarse-grained implicit-solvent model of self-assembled lipid membranes with a Langevin thermostat. Here we consider only the case wherein the nanoparticle–nanoparticle interaction is repulsive, only the concave surface of the nanoparticle interacts attractively with the lipid head groups and only the outer surface of the vesicle is exposed to the nanoparticles. Upon their adhesion on the vesicle, the curved nanoparticles g
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Hu, Guangxia, Hui Yin, Chunxiang Li, Suxiu Ng, Xi Jiang Yin, and Gong Hao. "Investigation of Lanolin Lipid-Based Nanoparticles as Carriers for Avobenzone." Nano LIFE 10, no. 04 (2020): 2040011. http://dx.doi.org/10.1142/s1793984420400115.

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The aim of this study is to develop and characterize lanolin lipid-based nanoparticles as carriers for avobenzone. Solid Lipid nanoparticles (SLNs) were prepared by the high-pressure homogenization technique. The influence of emulsifiers, avobenzone content in lipid (0–20[Formula: see text]wt.%), solid lipid blends’ composition and dispersions’ solid content on nanoparticles size, zeta potentials, PI value, stability, matrix structure and UV absorption were investigated. The matrix structure of the lipids and the blends was investigated by using X-ray diffraction (XRD) techniques. The particle
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R., Redya Naik. "Human Paraoxonase-1: Functional Insights Within PLGA-Based Nanoparticles." International Journal of Pharmacy and Biological Sciences (IJPBS) 9, no. 2 (2019): 1519–23. https://doi.org/10.5281/zenodo.13621929.

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Abstract Human serum paraoxonase-1 (PON1) is a calcium dependent interfacial activated membrane protein associated with high density lipoproteins (HDL) play significant role in fundamental biological processes. This study determines the feasibility of formulating PON1 loaded solid lipid nanoparticles for developing a surrogate for the HDL associated PON1 in the form of PLGA (Poly Lactic glycolic acid) based solid lipid nano formulations. Studies were made on the preparation of h-PON1(human Paraoxonase-1) loaded solid lipids nano formulations with PLGA and all activities of PON-1 like lactonase
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Lin, Yang, Xuehua Chen, Ke Wang, Li Liang, and Hongxia Zhang. "An Overview of Nanoparticle-Based Delivery Platforms for mRNA Vaccines for Treating Cancer." Vaccines 12, no. 7 (2024): 727. http://dx.doi.org/10.3390/vaccines12070727.

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With its unique properties and potential applications, nanoparticle-based delivery platforms for messenger RNA (mRNA) vaccines have gained significant attention in recent years. Nanoparticles have the advantages of enhancing immunogenicity, targeting delivery, and improving stability, providing a new solution for drug and vaccine delivery. In some clinical studies, a variety of nanoparticle delivery platforms have been gradually applied to a wide range of vaccine applications. Current research priorities are exploring various types of nanoparticles as vaccine delivery systems to enhance vaccin
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Pranali, Jadhav Pranali Hatwar Gajanan Sanap. "Review On Lipid Based Carrier As A Drug Delivery System." International Journal in Pharmaceutical Sciences 1, no. 12 (2023): 179–91. https://doi.org/10.5281/zenodo.10352354.

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Lipid nanocarriers represent an alternative to polymeric nanoparticles, liposomes, and emulsions. Nanostructured Lipid Nanocarriers (NLCs), considered as the second-generation lipid carriers, aim to address the limitations of Solid Lipid Nanoparticles. They are employed across diverse therapeutic approaches and were initially designed for delivering lipophilic drugs, but their effectiveness with hydrophilic drugs is now well-established. The biocompatibility of lipids underpins their emergence as a promising avenue for drug delivery, exhibiting superior traits compared to other lipid formulati
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Dissertations / Theses on the topic "Lipid Based Nanoparticles"

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Zhang, Mengzi. "DEVELOPMENTS OF LIPID-BASED NANOPARTICLES FOR THERAPEUTIC DRUG DELIVERY." The Ohio State University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=osu1417025932.

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Mohamed, Noor Norhayati. "Lipid-based nanoparticles for topical delivery of hair growth therapeutic molecules." Thesis, University College London (University of London), 2017. http://discovery.ucl.ac.uk/10024622/.

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INTRODUCTION: Androgenic alopecia (AA) patients usually have high levels of dihydrotestosterone on their balding scalp area. Currently, dutasteride (DST) is given orally and has systemic adverse effects; diminished sexual desire, increased depression and ejaculation disorder. Topical administration of DST is an appropriate drug-delivery strategy with the potential to reduce systemic side effect, skin irritation and cytotoxicity effects. MATERIALS AND METHOD: Chitosan oligomer (CSO) conjugated with stearic acid (SA) or lauric acid (LA) was synthesised and characterised. Dutasteride-loaded nanos
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Cheng, Xinwei. "Development of a Lipid Nanoparticle-based Antisense Delivery Platform for Cancer Therapy." The Ohio State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=osu154323360801958.

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CARDUCCI, Federica. "Self-assembled nanomaterials: an extended structural characterization of lipid nanoparticles and guanosine-based hydrogels." Doctoral thesis, Università Politecnica delle Marche, 2018. http://hdl.handle.net/11566/253135.

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Questa tesi di dottorato riguarda la caratterizzazione biofisica e strutturale di due diversi tipi di nanomateriali, uno basato su molecole lipidiche e l'altro su derivati degli acidi nucleici, che hanno in comune il meccanismo alla base della loro formazione, e cioè l'autoassemblaggio. La tesi è strutturata in 9 capitoli. Il capitolo 1 fornisce una breve introduzione sui sistemi lipidici utilizzati nel Drug Delivery. Tale introduzione è seguita da una discussione sui principi di base del polimorfismo lipidico in acqua e sull'utilizzo della tecnica di diffrazione a raggi X (XRD) per l'identifi
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Lu, Yaowei. "Multicompartmental lipid-based Janus nanoparticles : influence of different amphiphilic starting materials on their formation mechanisms and their suitability as drug delivery vehicles." Electronic Thesis or Diss., université Paris-Saclay, 2025. http://www.theses.fr/2025UPASQ009.

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Les nanoparticules Janus (JNP) asymétriques innovantes à base de lipides développées à l'Institut Galien peuvent servir de nouveaux vecteurs de délivrance de médicaments ou de transporteur d'agents diagnostiques dans le domaine des nanotechnologies. Pour obtenir ce type de particules anisotropes, différentes matières premières (phospholipides et tensioactifs à base de PEG courts ou dérivés amphiphiles de cyclodextrines) et méthodes de préparation (homogénéisation haute pression à chaud ou nanoprécipitation) ont été comparées. Ensuite, nous avons essayé d'optimiser ces JNP, en termes à la fois
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Varanasi, Ramya. "Advancing in-vitro blood-brain barrier models using lipid-based nanoparticles as a strategy for drug delivery." Thesis, The University of Sydney, 2020. https://hdl.handle.net/2123/25558.

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Introduction: The survival rate of neurological diseases such as brain cancer has remained poor at 1% over the last 30 years despite improvements in technology and novel medicines entering the market. The key obstacle in the treatment of any neurological disease is the blood brain barrier (BBB), a restrictive barrier which ensures the homeostasis of the central nervous system. Developments in lipid-based nanoparticles have presented the opportunity to deliver medicine across the BBB due to their size and ability to tune the ideal properties required to cross. By using human physio-mimicking mo
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Liang, Chao. "Aptamer-functionalized lipid nanoparticles targeting osteoblasts as a novel RNA Interference-based bone anabolic strategy." HKBU Institutional Repository, 2016. https://repository.hkbu.edu.hk/etd_oa/325.

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Osteoporosis remain major clinical challenges. RNA interference (RNAi) provides a promising approach for promoting osteoblastic bone formation to settle the challenges. However, the major bottleneck for translating RNAi with efficacy and safety to clinical bone anabolic strategy is lack of osteoblast-specific delivery systems for osteogenic siRNAs. Previously, we developed a targeting system involving DOTAP-based cationic liposomes attached to oligopeptides (AspSerSer)6, (also known as (DSS)6), which had good affinity for bone formation surface. Using this system, osteogenic Pleckstrin Homolog
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Wijagkanalan, Wassana. "Development of novel anti-inflammatory therapy based on macrophage-selective drug targeting using mannosylated lipid nanoparticles." 京都大学 (Kyoto University), 2009. http://hdl.handle.net/2433/124057.

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Dong, Xiaowei. "LIPID-BASED PACLITAXEL AND DOXORUBICIN NANOPARTICLES TO OVERCOME P-GP-MEDIATED DRUG RESISTANCE IN SOLID TUMORS." UKnowledge, 2009. http://uknowledge.uky.edu/gradschool_diss/724.

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Multidrug resistance (MDR) is a major obstacle limiting chemotherapeutic efficacy. The purpose of these studies was to investigate the potential application of injectable paclitaxel (PX) and doxorubicin (Dox)-loaded nanoparticles (NPs) engineered from oil-in-water microemulsion precursors for overcoming P-glycoprotein (P-gp)- mediated drug resistance in solid tumors. An in-vitro study was performed to test whether the oil (stearyl alcohol and cetyl alcohol) used to make lipid nanoparticles could be metabolized. The results showed that the concentrations of the fatty alcohols within nanoparticl
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Maheshwari, Neeraj. "Biofuntionalisation of PLGA based polymer nanoparticles for vectorization : interaction with biomimetic lipid membranes and bio-controlled release." Thesis, Compiègne, 2017. http://www.theses.fr/2017COMP2357.

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Cette thèse vise à développer des nanoparticules de PLGA pour la vectorisation et à étudier l’interaction de ces nanoparticules avec des bicouches phospholipidiques imitant les membranes cellulaires. Pour la vectorisation passive, les changements physico-chimiques ont été contrôlés en incubant les NPs de PLGA (50:50) dans différentes conditions de pH tamponné à des intervalles de temps accrus. Le PLGA a montré plusieurs comportements de dégradation différant selon le pH. La formation de pores a été observée à pH élevé (conditions basiques) tout en préservant le volume des particules mais en mo
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Book chapters on the topic "Lipid Based Nanoparticles"

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Lakshmi, S. Mohana, and C. K. Ashok Kumar. "Lipid-Based Nanoparticles." In Advances in Novel Phytopharmaceuticals. CRC Press, 2024. http://dx.doi.org/10.1201/9781003300588-7.

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Khunt, Dignesh, Bhavinkumar Gayakvad, Vidhi Modi, et al. "Solid Lipid Nanoparticles." In Lipid-Based Drug Delivery Systems. Jenny Stanford Publishing, 2023. http://dx.doi.org/10.1201/9781003459811-2.

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Wen, Jingyuan, Shuo Chen, and Guanyu Chen. "Solid Lipid Nanoparticles." In Emulsion-based Systems for Delivery of Food Active Compounds. John Wiley & Sons, Ltd, 2018. http://dx.doi.org/10.1002/9781119247159.ch5.

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Zhu, Yimei, Hiromi Inada, Achim Hartschuh, et al. "Solid Lipid-Based Nanoparticles." In Encyclopedia of Nanotechnology. Springer Netherlands, 2012. http://dx.doi.org/10.1007/978-90-481-9751-4_100786.

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Andrade, Raquel G. D., Sérgio R. S. Veloso, Elisabete M. S. Castanheira, and Ligia R. Rodrigues. "Magnetic Lipid-Based Nanoparticles." In Magnetic Polymer Composites and Their Emerging Applications. CRC Press, 2024. http://dx.doi.org/10.1201/9781003454236-16.

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Kuai, Rui, Lukasz J. Ochyl, Anna Schwendeman, and James J. Moon. "Lipid-Based Nanoparticles for Vaccine Applications." In Biomedical Engineering: Frontier Research and Converging Technologies. Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-21813-7_8.

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Calderón-Colón, Xiomara, and Richard Egan. "Lipid-Based Nanoparticles for RNA Delivery." In Methods in Molecular Biology. Springer US, 2024. http://dx.doi.org/10.1007/978-1-0716-3918-4_25.

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Singh, Anju, and Kamal Kishor Thakur. "Lipid-Based Nanoparticles to Diagnose and Cure Cancer." In Nanoparticles in Cancer Theranostics. CRC Press, 2024. http://dx.doi.org/10.1201/9781003463191-14.

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Kumari, Bhavna, and Anupam Prakash. "Lipid-Based Nanoparticles as Drug Delivery Agents." In Nanoparticles in Diagnosis, Drug Delivery and Nanotherapeutics. CRC Press, 2023. http://dx.doi.org/10.1201/9781003316398-6.

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Liu, Yang, and Leaf Huang. "Lipid-Coated Cisplatin Nanoparticles for Insoluble Drug Loading." In Liposome-Based Drug Delivery Systems. Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-49231-4_7-1.

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Conference papers on the topic "Lipid Based Nanoparticles"

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Batista, Daniel V., and Marco S. Reis. "Balancing modelling complexity and experimental effort for conducting QbD on lipid nanoparticles (LNPs) systems." In The 35th European Symposium on Computer Aided Process Engineering. PSE Press, 2025. https://doi.org/10.69997/sct.163183.

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The promising properties of lipid nanoparticles (LNPs) as drug carriers have been attracting significant attention in the field of drug delivery. However, further research is still required for a better understanding of their integration in the pharmaceutical industry. The Quality by Design (QbD) approach aims at ensuring the safety and efficiency in the development of new drugs, through an holistic, risk-based approach that gathers all sources of knowledge available about the system under analysis. One key resource of the QbD framework is the rich toolkit of Design of Experiments (DOE), to de
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Kimura, Niko, and Shinya Sakuma. "Sequential Assembly of Lipid Molecules Broadens Designability of Lipid-Based Nanoparticles." In 2024 IEEE 37th International Conference on Micro Electro Mechanical Systems (MEMS). IEEE, 2024. http://dx.doi.org/10.1109/mems58180.2024.10439443.

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Lund, Sean, Nicole Collete, Anupama Sinha, et al. "Imaging in vivo Lipid Nanoparticle Delivery." In Proposed for presentation at the Next Generation Lipid-Based Nanoparticles Delivery Summit held July 19-21, 2022 in Boston, MA United States. US DOE, 2022. http://dx.doi.org/10.2172/2003836.

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Gianni, Ciofani. ""Lipid-based magnetic nanoparticles for glioma treatment: In vivo validation "." In 4th URSI Atlantic RadioScience Conference. URSI – International Union of Radio Science, 2024. http://dx.doi.org/10.46620/ursiatrasc24/mlzk1938.

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Ciofani, Gianni. "Lipid-based magnetic nanoparticles for glioma treatment: Towards a personalized approach." In XXXVth URSI General Assembly and Scientific Symposium. URSI – International Union of Radio Science, 2023. http://dx.doi.org/10.46620/ursigass.2023.0131.zjxx5854.

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Kellerer, Thomas, Tanja Grawert, Florian Schorre, et al. "An Image Based Real-Time 3D Particle Tracking Fluorescence Lifetime Imaging Microscope to Follow Lipid Nanoparticles." In Microscopy Histopathology and Analytics. Optica Publishing Group, 2024. http://dx.doi.org/10.1364/microscopy.2024.mm5a.6.

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A modified Two-Photon Microscopy setup tracks freely diffusing nanoparticles in 3D and in real-time. It can measure fluorescence lifetime and microenvironmental properties, such as pH, for applications in drug delivery systems based on lipid nanoparticles.
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Jolly, Kevon, and Fan Zhang. "1110 In situ engineering of myeloid cells through dendrimer-based lipid nanoparticles." In SITC 39th Annual Meeting (SITC 2024) Abstracts. BMJ Publishing Group Ltd, 2024. http://dx.doi.org/10.1136/jitc-2024-sitc2024.1110.

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Liu, Xuan, Zhaoxiong Wan, Yuanwei Zhang, and Yuwei Liu. "Optically computed phase microscopy to assess cellular uptake of lipid nanoparticles." In CLEO: Applications and Technology. Optica Publishing Group, 2022. http://dx.doi.org/10.1364/cleo_at.2022.atu5i.6.

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We developed a novel optically computed phase microscopy (OCPM) system, for depth-resolved phase imaging. We used OCPM to assess cellular uptake of lipid nanoparticles (LNPs), for the optimization of drug delivery systems based on LNPs.
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Lund, Sean, Nicole Collette, Anupama Sinha, et al. "Imaging and Efficacy of in vivo Lipid Nanoparticle Delivery in Genome Editing." In Proposed for presentation at the Next Generation Lipid-Based Nanoparticles Delivery Summit held July 19-21, 2022 in Boston, MA United States. US DOE, 2022. http://dx.doi.org/10.2172/2003928.

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Nikolaeva, V. A., M. Zoughaib, M. I. Kamalov, et al. "CYTOTOXIC AND PROOXIDANT EFFECTS OF AN ANTITUMOR FORMULATION OF MENADIONE BASED ON SOLID LIPID NANOPARTICLES." In X Международная конференция молодых ученых: биоинформатиков, биотехнологов, биофизиков, вирусологов и молекулярных биологов — 2023. Novosibirsk State University, 2023. http://dx.doi.org/10.25205/978-5-4437-1526-1-107.

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Solid lipid nanoparticles (SLN) containing encapsulated menadione and modified with L-arginyl-glycyl-L-aspartic acid (RGD) peptide were obtained. The colloidal characteristics of the formulations were studied and their influence on the viability and oxidative status of tumor cells was assessed.
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