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Dissertations / Theses on the topic 'Lipid Based Nanoparticles'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

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1

Zhang, Mengzi. "DEVELOPMENTS OF LIPID-BASED NANOPARTICLES FOR THERAPEUTIC DRUG DELIVERY." The Ohio State University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=osu1417025932.

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Mohamed, Noor Norhayati. "Lipid-based nanoparticles for topical delivery of hair growth therapeutic molecules." Thesis, University College London (University of London), 2017. http://discovery.ucl.ac.uk/10024622/.

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INTRODUCTION: Androgenic alopecia (AA) patients usually have high levels of dihydrotestosterone on their balding scalp area. Currently, dutasteride (DST) is given orally and has systemic adverse effects; diminished sexual desire, increased depression and ejaculation disorder. Topical administration of DST is an appropriate drug-delivery strategy with the potential to reduce systemic side effect, skin irritation and cytotoxicity effects. MATERIALS AND METHOD: Chitosan oligomer (CSO) conjugated with stearic acid (SA) or lauric acid (LA) was synthesised and characterised. Dutasteride-loaded nanos

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3

Cheng, Xinwei. "Development of a Lipid Nanoparticle-based Antisense Delivery Platform for Cancer Therapy." The Ohio State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=osu154323360801958.

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4

CARDUCCI, Federica. "Self-assembled nanomaterials: an extended structural characterization of lipid nanoparticles and guanosine-based hydrogels." Doctoral thesis, Università Politecnica delle Marche, 2018. http://hdl.handle.net/11566/253135.

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Questa tesi di dottorato riguarda la caratterizzazione biofisica e strutturale di due diversi tipi di nanomateriali, uno basato su molecole lipidiche e l'altro su derivati degli acidi nucleici, che hanno in comune il meccanismo alla base della loro formazione, e cioè l'autoassemblaggio. La tesi è strutturata in 9 capitoli. Il capitolo 1 fornisce una breve introduzione sui sistemi lipidici utilizzati nel Drug Delivery. Tale introduzione è seguita da una discussione sui principi di base del polimorfismo lipidico in acqua e sull'utilizzo della tecnica di diffrazione a raggi X (XRD) per l'identifi

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5

Lu, Yaowei. "Multicompartmental lipid-based Janus nanoparticles : influence of different amphiphilic starting materials on their formation mechanisms and their suitability as drug delivery vehicles." Electronic Thesis or Diss., université Paris-Saclay, 2025. http://www.theses.fr/2025UPASQ009.

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Les nanoparticules Janus (JNP) asymétriques innovantes à base de lipides développées à l'Institut Galien peuvent servir de nouveaux vecteurs de délivrance de médicaments ou de transporteur d'agents diagnostiques dans le domaine des nanotechnologies. Pour obtenir ce type de particules anisotropes, différentes matières premières (phospholipides et tensioactifs à base de PEG courts ou dérivés amphiphiles de cyclodextrines) et méthodes de préparation (homogénéisation haute pression à chaud ou nanoprécipitation) ont été comparées. Ensuite, nous avons essayé d'optimiser ces JNP, en termes à la fois

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6

Varanasi, Ramya. "Advancing in-vitro blood-brain barrier models using lipid-based nanoparticles as a strategy for drug delivery." Thesis, The University of Sydney, 2020. https://hdl.handle.net/2123/25558.

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Introduction: The survival rate of neurological diseases such as brain cancer has remained poor at 1% over the last 30 years despite improvements in technology and novel medicines entering the market. The key obstacle in the treatment of any neurological disease is the blood brain barrier (BBB), a restrictive barrier which ensures the homeostasis of the central nervous system. Developments in lipid-based nanoparticles have presented the opportunity to deliver medicine across the BBB due to their size and ability to tune the ideal properties required to cross. By using human physio-mimicking mo

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Liang, Chao. "Aptamer-functionalized lipid nanoparticles targeting osteoblasts as a novel RNA Interference-based bone anabolic strategy." HKBU Institutional Repository, 2016. https://repository.hkbu.edu.hk/etd_oa/325.

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Osteoporosis remain major clinical challenges. RNA interference (RNAi) provides a promising approach for promoting osteoblastic bone formation to settle the challenges. However, the major bottleneck for translating RNAi with efficacy and safety to clinical bone anabolic strategy is lack of osteoblast-specific delivery systems for osteogenic siRNAs. Previously, we developed a targeting system involving DOTAP-based cationic liposomes attached to oligopeptides (AspSerSer)6, (also known as (DSS)6), which had good affinity for bone formation surface. Using this system, osteogenic Pleckstrin Homolog

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8

Wijagkanalan, Wassana. "Development of novel anti-inflammatory therapy based on macrophage-selective drug targeting using mannosylated lipid nanoparticles." 京都大学 (Kyoto University), 2009. http://hdl.handle.net/2433/124057.

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9

Dong, Xiaowei. "LIPID-BASED PACLITAXEL AND DOXORUBICIN NANOPARTICLES TO OVERCOME P-GP-MEDIATED DRUG RESISTANCE IN SOLID TUMORS." UKnowledge, 2009. http://uknowledge.uky.edu/gradschool_diss/724.

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Multidrug resistance (MDR) is a major obstacle limiting chemotherapeutic efficacy. The purpose of these studies was to investigate the potential application of injectable paclitaxel (PX) and doxorubicin (Dox)-loaded nanoparticles (NPs) engineered from oil-in-water microemulsion precursors for overcoming P-glycoprotein (P-gp)- mediated drug resistance in solid tumors. An in-vitro study was performed to test whether the oil (stearyl alcohol and cetyl alcohol) used to make lipid nanoparticles could be metabolized. The results showed that the concentrations of the fatty alcohols within nanoparticl

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10

Maheshwari, Neeraj. "Biofuntionalisation of PLGA based polymer nanoparticles for vectorization : interaction with biomimetic lipid membranes and bio-controlled release." Thesis, Compiègne, 2017. http://www.theses.fr/2017COMP2357.

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Cette thèse vise à développer des nanoparticules de PLGA pour la vectorisation et à étudier l’interaction de ces nanoparticules avec des bicouches phospholipidiques imitant les membranes cellulaires. Pour la vectorisation passive, les changements physico-chimiques ont été contrôlés en incubant les NPs de PLGA (50:50) dans différentes conditions de pH tamponné à des intervalles de temps accrus. Le PLGA a montré plusieurs comportements de dégradation différant selon le pH. La formation de pores a été observée à pH élevé (conditions basiques) tout en préservant le volume des particules mais en mo

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11

Chien, Chih-Ta. "Development of a saposin A based native-like phospholipid bilayer system for NMR studies." Thesis, University of Cambridge, 2019. https://www.repository.cam.ac.uk/handle/1810/289703.

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Membrane proteins are important targets that represent more than 50% of current drug targets. However, characterisation of membrane proteins falls behind compared to their soluble counterparts. The most challenging part of membrane protein research is finding a suitable membrane mimetic that stabilises them in solution and maintains their native structure and function. The recently developed saposin-A (SapA) based lipid nanoparticle system seems to be advantageous over existing membrane mimetic system. It provides a native-like lipid bilayer, high incorporation yield and more importantly size

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12

Kleemann, Elke. "Polyethylenimine- and lipid-based nanoparticles as gene and drug delivery systems for aerosol therapy to the lung." [S.l.] : [s.n.], 2005. http://archiv.ub.uni-marburg.de/diss/z2005/0363/.

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13

Bayon, Emilie. "Nouveau système de délivrance d'antigènes à base de nanoparticules lipidiques (Lipidots) pour formulation vaccinale." Thesis, Université Grenoble Alpes (ComUE), 2018. http://www.theses.fr/2018GREAV003/document.

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Les vaccins représentent l’un des progrès majeurs de l’Histoire pour la santé publique, concrétisant notamment l’éradication de la variole en 1980. Les vaccins historiques, à base de pathogènes entiers atténués ou inactivés et donc très immunogènes ont été progressivement remplacés par des vaccins à sous-unités, beaucoup plus sûrs mais en contrepartie moins immunogènes. Des adjuvants tels que des vecteurs et des molécules immunostimulantes ont donc été incorporés dans les formulations vaccinales dans le but de générer des réponses immunitaires de grande amplitude. Cependant, les principaux adj

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14

Hanson, Melissa C. (Melissa Catherine). "Enhancement of HIV vaccine efficacy via lipid nanoparticle-based adjuvants." Thesis, Massachusetts Institute of Technology, 2014. http://hdl.handle.net/1721.1/97975.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biological Engineering, February 2015..<br>Cataloged from PDF version of thesis. "December 2014."<br>Includes bibliographical references (pages 93-108).<br>Adjuvants are immunomodulators and/or formulations/delivery vehicles which enhance immune responses to vaccines. The lack of progress in the development of an HIV humoral vaccine is due, in part, to the absence of available adjuvants which can be sufficiently potent with minimal adverse side effects. The main goal of this thesis was to develop nanoparticles as HIV vaccine

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15

Bouchaala, Redouane. "Nanoparticules organiques fluorescentes à base de lipides : intégrité et relargage de principes actifs in vitro et in vivo." Thesis, Strasbourg, 2017. http://www.theses.fr/2017STRAJ045/document.

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Pour une application optimale des nanovecteurs comme système de délivrance de médicaments, il est nécessaire de caractériser pleinement leur intégrité, et leurs propriétés d’encapsulation et de libération de leur contenue. Mon projet de doctorat consiste à développer des méthodes basées sur la fluorescence pour caractériser l'intégrité de ces nanovecteurs lipidiques et la libération des molécules actives in vitro et in vivo. Premièrement, en utilisant le FRET entre deux fluorochromes infrarouges spécialement conçus, l'intégrité des nanovecteurs lipidiques dans le sang et la tumeur cible a été

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16

Zhao, Zongmin. "Factors that Affect the Immunogenicity of Lipid-PLGA Nanoparticle-Based Nanovaccines against Nicotine Addiction." Diss., Virginia Tech, 2017. http://hdl.handle.net/10919/88033.

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Tobacco smoking has consistently been the leading cause of preventable diseases and premature deaths. Currently, pharmacological interventions have only shown limited smoking cessation efficacy and sometimes are associated with severe side effects. As an alternative, nicotine vaccines have emerged as a promising strategy to combating nicotine addiction. However, conventional conjugate nicotine vaccines have shown limited ability to induce a sufficiently strong immune response due to their intrinsic shortfalls. In this study, a lipid-poly(lactic-co-glycolic acid) (PLGA) nanoparticle-based nex

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17

Terp, Megan Cavanaugh. "Improved Nanoparticle Preparation and Delivery Technology for DOTAP and Oligonucleotide Based Lipoplexes." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1338301430.

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18

Massiot, Julien. "Conception de nanomédicaments photostimulables à base de lipides et porphyrines ou de conjugués lipide-porphyrine pour la libération contrôlée de substances actives." Thesis, Université Paris-Saclay (ComUE), 2018. http://www.theses.fr/2018SACLS290.

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L’objectif des travaux de cette thèse était de développer un système de délivrance stimulus-sensible innovant. Basé sur des vésicules lipidiques, il permet la libération d’une substance anti-cancéreuse hydrophile encapsulée dans leur cœur aqueux, sous l’effet de la lumière. Des porphyrines, incorporées dans leur bicouche, permettent, une fois illuminées, de générer de l’oxygène singulet qui oxyde les chaînes acyl insaturées des phospholipides. Cela induit une augmentation de la perméabilité des liposomes et permet la libération de leur cargo. Nous avons, dans un premier temps, effectué une sél

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19

Brody, Leigh. "Design, synthesis and biological evaluation of novel lipid-based nanoparticle delivery system for metabolic re-engineering." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/14406.

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Dietary supplementation with fibre has been shown to ameliorate features of the metabolic syndrome and inhibit malignant growth in certain types of cancer. These effects have been linked to short-chain fatty acids (SCFA), mostly acetate. However, the ubiquitous role of SCFAs in metabolism, combined with a short tissue half-life and the non-targeted nature of oral and peripheral administrations make achieving phenotypically relevant levels of SCFA by standard delivery techniques challenging and limit their therapeutic potential. Liposomal encapsulation of a therapeutic agent overcomes these iss

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20

Nahle, Sara. "Réponse macrophagique aux nanomatériaux carbonés : effets de leur caractéristiques physiques et chimiques sur le transcriptome Carbon-based nanomaterials induce inflammation and autophagy in rat alveolar macrophages Single wall and multiwall carbon nanotubes induce different toxicological responses in rat alveolar macrophages Gene expression profiling of alveolar macrophages exposed to non-functionalized, anionic or cationic multi-walled carbon nanotubes shows three different mechanisms of toxicity Cytotoxicity and global transcriptional responses induced by zinc oxide nanoparticles NM 110 in PMA-differentiated THP-1 cells Protein and lipid homeostasis altered in rat macrophages after exposure to metallic oxide nanoparticles." Thesis, Université de Lorraine, 2019. http://www.theses.fr/2019LORR0142.

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Les nanomatériaux carbonés (NMC) sont très utilisés dans le monde industriel et leurs applications, nombreuses, sont en plein développement. L’absence de réglementation pour leur préparation et leur emploi fait qu’il est nécessaire comme pour tous les nano-objets, de déterminer le risque qu’une exposition fait courir à l’Homme et d’adapter la législation en conséquence. Une meilleure connaissance de leur potentiel toxique est donc nécessaire. Les difficultés de plus en plus grandes pour utiliser les modèles animaux, rend nécessaire le développement d’études avec des lignées cellulaires au sein

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21

Hsu, Shu-hao. "The Biological Functions of miR-122 and its Therapeutic Application in Liver Cancer." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1338316658.

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22

Marchand, Raphaël. "Conception et caractérisation d'un dispositif à base de nanopores destiné à l'enregistrement électrique de l'activité de canaux ioniques membranaires." Thesis, Toulouse 3, 2016. http://www.theses.fr/2016TOU30229/document.

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Les canaux ioniques sont des protéines membranaires permettant le transport ionique au travers des membranes biologiques. Du fait de leur omniprésence dans l'organisme, ils représentent une classe de cibles thérapeutiques encore actuellement peu exploitée du fait de limitations expérimentales dans leur étude. La mesure électrique de l'activité des canaux ioniques au sein de bicouches biomimétiques reconstituées in vitro permettrait de répondre à ces limitations. Cependant, il n'existe actuellement pas de système satisfaisant au cahier des charges complet pour de telles analyses : stabilité et

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23

Carradori, Dario. "Novel nanoparticle-based drug delivery system for neural stem cell targeting and differentiation." Thesis, Angers, 2017. http://www.theses.fr/2017ANGE0056/document.

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Les cellules souches neurales (CSNs) se situent dans des régions spécifiques du système nerveux central qui sont appelées niches. Ces cellules sont capables de se répliquer ou se différentier en cellules neurales spécialisées (neurones, astrocytes et oligodendrocytes). C’est grâce à cette propriété de différentiation que les CSNs sont étudiées comme thérapie chez les patients atteints d’une maladie neurodégénérative. En effet, elles pourraient remplacer les cellules neurales altérées et ainsi restaurer les fonctions neurologiques. De nombreuses approches ont été développées afin de stimuler la

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24

TRUZZI, ELEONORA. "PROGETTAZIONE E SVILUPPO DI SISTEMI DI VEICOLAZIONE NANOPARTICELLARI A BASE DI LIPIDI E OLIGOSACCARIDI PER LA SOMMINISTRAZIONE DI COMPOSTI ATTIVI." Doctoral thesis, Università degli studi di Modena e Reggio Emilia, 2020. http://hdl.handle.net/11380/1201019.

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I sistemi di veicolazione del farmaco sono largamente studiati come tra i più efficienti metodi per migliorare l’efficacia dei farmaci. Negli ultimi vent’anni un’enorme attenzione è stata focalizzata sui sistemi nanometrici di veicolazione che sono in grado di interagire selettivamente con organismi patogeni, cellule o tessuti. Tra i gli eccipienti utilizzabili nella preparazione di questi sistemi, lipidi e oligosaccaridi mostrano una elevata biocompatibilità, biodegradabilità e idoneità per la somministrazione di farmaci attraverso varie vie. Lo scopo della tesi è stato lo sviluppo di sistemi

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25

Pereira, Telmo Galvão. "Development of new gene delivery carriers based on lipid nanoparticles." Master's thesis, 2017. http://hdl.handle.net/10362/28739.

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Gene therapy is a potential strategy for treating numerous gene-associated human diseases. The main constrain for the successful application of gene-based therapy is dependent on the efficient gene delivery system, virus being so far, the most effective. However, this delivery system can have oncogenic and immunogenic effects, and induce inflammatory responses. Thus, nanoparticulate non-viral vectors have been developed based on lipid and polymers overcoming some of these concerns, besides having safety advantages. Among these, solid lipid nanoparticles (SLNs) are of particular relevance due t

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Yanasarn, Nijaporn. "Lipid based nanocarriers for chemotherapeutic drug docetaxel and vaccine delivery." Thesis, 2011. http://hdl.handle.net/1957/23014.

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Nanoscale drug delivery systems have a great impact in current medical field. These carriers have the potential to improve the efficacy and reduce the toxicity of various medicinal products. A broad variety of different lipid based carriers had been developed and used as delivery systems in the past decades. This dissertation focused on the development of solid lipid nanoparticles (SLN) as delivery systems for a chemotherapeutic agent, docetaxel, and the use of liposomes as a carrier for recombinant protein vaccines. Docetaxel is a potent anticancer drug. However, there continues to be a need

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27

Bento, Daniel Jorge Silva. "Oral films based on lipid nanoparticles for drug administration: a computational and experimental approach." Master's thesis, 2018. http://hdl.handle.net/10316/86517.

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Dissertação de Mestrado em Química Medicinal apresentada à Faculdade de Ciências e Tecnologia<br>This work focuses on the development of a computational platform able to provide a comprehensive analysis of dissolution profiles, exploring mathematical models, similarity analysis, and lag time using R programming. Also, a pharmaceutical approach conducting the study of the in vitro behavior of oral films, based on hydrogels and lipid nanoparticles co-encapsulating drugs with distinct physicochemical characteristics was performed. Subsequently, the computational approach developed was used to ana

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28

Tokle, Tanushree. "Design and fabrication of functional lipid nanoparticles based on control of interfacial properties using biopolymers." 2012. https://scholarworks.umass.edu/dissertations/AAI3545992.

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The main objective of this research was to better understand the formation, stability and properties of emulsions having lipid nanoparticles with tunable functional properties by controlling the composition and structure of the biopolymer interface, in order to develop better food-grade delivery systems. Initially, the influence of environmental stresses (pH, heating and salts) on the physicochemical properties of cationic lactoferrin (LF)-stabilized oil-in-water emulsions was investigated. At ambient temperature, the emulsions were found to be stable at all times except when pH was close to p

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29

Chiang, Tsaiyu, та 江彩語. "Lipid-Based Nanoparticles Inhibiting SDF1-α/ CXCR4 axis and Delivering Anti-angiogenic siRNA for Ttreating Liver Fibrosis". Thesis, 2015. http://ndltd.ncl.edu.tw/handle/rs3vu4.

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Liu, Jia Yu, and 劉家瑜. "CXCR4 Targeted Lipid-Based Nanoparticles Delivering VEGF siRNA Modulate Tumor Microenvironment and Achieve Potent Anti-tumor Response in Liver Cancer." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/ab7k8h.

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31

Kleemann, Elke [Verfasser]. "Polyethylenimine- and lipid-based nanoparticles as gene and drug delivery systems for aerosol therapy to the lung / vorgelegt von Elke Kleemann." 2005. http://d-nb.info/975999745/34.

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Marques, Márcia Cristina Teixeira. "Evaluation of the behaviour of bio-based nanostructures in food systems." Master's thesis, 2021. http://hdl.handle.net/1822/73455.

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Dissertação de mestrado em Biotecnologia<br>The growing consumers’ interest in healthier foods has led the food industry to develop functional foods specifically designed to improve human health, well-being, and performance. Curcumin is a natural polyphenol that presents numerous biological activities. However, curcumin has low water solubility, poor chemical stability, and low bioavailability. Lipid-based nanostructured delivery systems can be used to encapsulate curcumin. In this study, solid lipid nanoparticles (SLNs) encapsulating curcumin were developed and incorporated into a gelatine fo

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33

Sherrod, Stacy D. "Development of Advanced Optics and High Resolution Instrumentation for Mass Spectrometry Based Proteomics." 2008. http://hdl.handle.net/1969.1/ETD-TAMU-2008-12-192.

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Imaging mass spectrometry (MS) analysis allows scientists the ability to obtain spatial and chemical information of analytes on a wide variety of surfaces. The ability to image biological analytes is an important tool in many areas of life science research, including: the ability to map pharmaceutical drugs in targeted tissue, to spatially determine the expression profile of specific proteins in healthy vs. diseased tissue states, and to rapidly interrogate biomolecular microarrays. However, there are several avenues for improving the imaging MS experiment for biological samples. Three signifi

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Biswas, Joydeep. "Novel Cationic Gemini Lipids, Click Chemistry Based Adducts And Amphiphile-Capped Silver Nanostructures : Synthesis, Aggregation And Biological Properties." Thesis, 2010. https://etd.iisc.ac.in/handle/2005/1894.

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The thesis entitled “Novel Cationic Gemini Lipids, Click Chemistry Based Adducts and Amphiphile-Capped Silver Nanostructures: Synthesis, Aggregation and Biological Properties” elucidates the design, synthesis, aggregation and gene transfection properties of novel gemini cationic lipids based on cholesterol and pseudoglyceryl backbone, and click chemistry based adducts. This thesis also elucidates the synthesis and aggregation properties of silver nanoparticles loaded cationic liposomes and silver nanorods stabilized by micellar solutions of gemini surfactants. The work has been divided into si

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Biswas, Joydeep. "Novel Cationic Gemini Lipids, Click Chemistry Based Adducts And Amphiphile-Capped Silver Nanostructures : Synthesis, Aggregation And Biological Properties." Thesis, 2010. http://etd.iisc.ernet.in/handle/2005/1894.

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The thesis entitled “Novel Cationic Gemini Lipids, Click Chemistry Based Adducts and Amphiphile-Capped Silver Nanostructures: Synthesis, Aggregation and Biological Properties” elucidates the design, synthesis, aggregation and gene transfection properties of novel gemini cationic lipids based on cholesterol and pseudoglyceryl backbone, and click chemistry based adducts. This thesis also elucidates the synthesis and aggregation properties of silver nanoparticles loaded cationic liposomes and silver nanorods stabilized by micellar solutions of gemini surfactants. The work has been divided into si

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Silva, Lígia Catarina Gomes da. "A novel multifunctional lipid-based nanoparticle for the delivery of siRNA to cancer cells and the tumor microenvironment." Doctoral thesis, 2012. http://hdl.handle.net/10316/20773.

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Garcês, Alexandra de Lurdes Pacheco. "Sistemas semissólidos à base de nanopartículas lipídicas." Master's thesis, 2016. http://hdl.handle.net/10284/5515.

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As nanopartículas lipídicas foram desenvolvidas no início dos anos 90 e, atendendo às vantagens que apresentam comparativamente a outros sistemas coloidais, têm-se demonstrado muito promissoras, tanto para uso cosmético como farmacêutico. No entanto, atualmente apenas existem comercializados produtos cosméticos à base de nanopartículas lipídicas, o que pode ser justificado pelas restrições regulamentares relacionadas com a introdução de medicamentos no mercado. Existem dois tipos de nanopartículas lipídicas, as nanopartículas de lípidos sólidos (Solid Lipid Nanoparticles, SLN) e os vetores lip

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