Log in

Relevant bibliographies by topics / Lipid Based Nanoparticles / Journal articles

To see the other types of publications on this topic, follow the link: Lipid Based Nanoparticles.

Journal articles on the topic 'Lipid Based Nanoparticles'

Author: Grafiati

Published: 5 June 2025

Last updated: 16 July 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'Lipid Based Nanoparticles.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Korzun, Tetiana, Abraham S. Moses, Parham Diba, et al. "From Bench to Bedside: Implications of Lipid Nanoparticle Carrier Reactogenicity for Advancing Nucleic Acid Therapeutics." Pharmaceuticals 16, no. 8 (2023): 1088. http://dx.doi.org/10.3390/ph16081088.

Full text

Abstract:

In biomedical applications, nanomaterial-based delivery vehicles, such as lipid nanoparticles, have emerged as promising instruments for improving the solubility, stability, and encapsulation of various payloads. This article provides a formal review focusing on the reactogenicity of empty lipid nanoparticles used as delivery vehicles, specifically emphasizing their application in mRNA-based therapies. Reactogenicity refers to the adverse immune responses triggered by xenobiotics, including administered lipid nanoparticles, which can lead to undesirable therapeutic outcomes. The key components

APA, Harvard, Vancouver, ISO, and other styles

2

Jaswinder, Singh *. "LIPID NANOPARTICULATE DRUG DELIVERY SYSTEMS." Journal of Pharma Research 8, no. 8 (2019): 557–63. https://doi.org/10.5281/zenodo.3374087.

Full text

Abstract:

<strong><em>ABSTRACT</em></strong> <strong><em>C</em></strong><em>olloidal particles of size range between 10 and 1000 nm are known as nanoparticles. Over the last few years, lipid based drug delivery systems such as solid lipid nanoparticle (SLN) and nanostructured lipid carrier (NLC) and lipid drug conjugate (LDC) have become the most promising drug delivery systems. Each preparation of the lipid based nanoparticles has advantages and disadvantages with respect to specific characteristics. The SLN is an excellent drug delivery system and has extensive prospects in the pharmaceutical field. N

APA, Harvard, Vancouver, ISO, and other styles

3

Jafar, Garnadi, R. Awaludin Nazal N, and Entris Sutrisno. "REVIEW: REVIEW ARTICLE LIPID-BASED NANOTECHNOLOGY." Medical Sains : Jurnal Ilmiah Kefarmasian 9, no. 1 (2024): 189–204. http://dx.doi.org/10.37874/ms.v9i1.1084.

Full text

Abstract:

Nanotechnology is defined as engineering the creation of materials, functions, and devices on the nanometer scale. Nanoscience is increasingly developing and becoming a part of various fields, such as electronics, materials, and biology. Lipid nanoparticles are a major application in nanotechnology. In formulas II and III, smaller results were obtained compared with the other formulas. Based on the results of this study, it can be concluded that the nanostructured lipid carrier system with solid lipid poloxamer and stearic acid with liquid soybean oil lipids obtained good characteristics, and

APA, Harvard, Vancouver, ISO, and other styles

4

Onteru, Sujeevan. "Lipid-based nanoparticles and their recent advances." GSC Advanced Research and Reviews 18, no. 3 (2024): 182–88. https://doi.org/10.5281/zenodo.11217314.

Full text

Abstract:

Lipid-based nanoparticles hold great potential for drug delivery, providing biocompatibility and the ability to encapsulate both hydrophilic and hydrophobic drugs. However, there are certain challenges associated with small molecules, such as leakage and premature release, which can compromise their effectiveness. Despite these challenges, lipid nanoparticles offer advantages in terms of solubility, stability, and targeted delivery, thereby reducing side effects. Additionally, they can be customized for specific molecules, ensuring biocompatibility and biodegradability. While complications may

APA, Harvard, Vancouver, ISO, and other styles

5

Chountoulesi, Maria, Natassa Pippa, Aleksander Forys, Barbara Trzebicka, and Stergios Pispas. "Structure-Based Evaluation of Hybrid Lipid–Polymer Nanoparticles: The Role of the Polymeric Guest." Polymers 16, no. 2 (2024): 290. http://dx.doi.org/10.3390/polym16020290.

Full text

Abstract:

The combination of phospholipids and block-copolymers yields advanced hybrid nanoparticles through the self-assembly process in an aqueous environment. The physicochemical features of the lipid/polymer components, like the lipid–polymer molar ratio, the macromolecular architecture of the block copolymer, the main transition temperature of the phospholipid, as well as the formulation and preparation protocol parameters, are some of the most crucial parameters for the formation of hybrid lipid/polymer vesicles and for the differentiation of their morphology. The morphology, along with other phys

APA, Harvard, Vancouver, ISO, and other styles

6

Olinger, Alexander D., Eric J. Spangler, P. B. Sunil Kumar, and Mohamed Laradji. "Membrane-mediated aggregation of anisotropically curved nanoparticles." Faraday Discussions 186 (2016): 265–75. http://dx.doi.org/10.1039/c5fd00144g.

Full text

Abstract:

Using systematic numerical simulations, we study the self-assembly of elongated curved nanoparticles on lipid vesicles. Our simulations are based on molecular dynamics of a coarse-grained implicit-solvent model of self-assembled lipid membranes with a Langevin thermostat. Here we consider only the case wherein the nanoparticle–nanoparticle interaction is repulsive, only the concave surface of the nanoparticle interacts attractively with the lipid head groups and only the outer surface of the vesicle is exposed to the nanoparticles. Upon their adhesion on the vesicle, the curved nanoparticles g

APA, Harvard, Vancouver, ISO, and other styles

7

Hu, Guangxia, Hui Yin, Chunxiang Li, Suxiu Ng, Xi Jiang Yin, and Gong Hao. "Investigation of Lanolin Lipid-Based Nanoparticles as Carriers for Avobenzone." Nano LIFE 10, no. 04 (2020): 2040011. http://dx.doi.org/10.1142/s1793984420400115.

Full text

Abstract:

The aim of this study is to develop and characterize lanolin lipid-based nanoparticles as carriers for avobenzone. Solid Lipid nanoparticles (SLNs) were prepared by the high-pressure homogenization technique. The influence of emulsifiers, avobenzone content in lipid (0–20[Formula: see text]wt.%), solid lipid blends’ composition and dispersions’ solid content on nanoparticles size, zeta potentials, PI value, stability, matrix structure and UV absorption were investigated. The matrix structure of the lipids and the blends was investigated by using X-ray diffraction (XRD) techniques. The particle

APA, Harvard, Vancouver, ISO, and other styles

8

R., Redya Naik. "Human Paraoxonase-1: Functional Insights Within PLGA-Based Nanoparticles." International Journal of Pharmacy and Biological Sciences (IJPBS) 9, no. 2 (2019): 1519–23. https://doi.org/10.5281/zenodo.13621929.

Full text

Abstract:

Abstract Human serum paraoxonase-1 (PON1) is a calcium dependent interfacial activated membrane protein associated with high density lipoproteins (HDL) play significant role in fundamental biological processes. This study determines the feasibility of formulating PON1 loaded solid lipid nanoparticles for developing a surrogate for the HDL associated PON1 in the form of PLGA (Poly Lactic glycolic acid) based solid lipid nano formulations. Studies were made on the preparation of h-PON1(human Paraoxonase-1) loaded solid lipids nano formulations with PLGA and all activities of PON-1 like lactonase

APA, Harvard, Vancouver, ISO, and other styles

9

Lin, Yang, Xuehua Chen, Ke Wang, Li Liang, and Hongxia Zhang. "An Overview of Nanoparticle-Based Delivery Platforms for mRNA Vaccines for Treating Cancer." Vaccines 12, no. 7 (2024): 727. http://dx.doi.org/10.3390/vaccines12070727.

Full text

Abstract:

With its unique properties and potential applications, nanoparticle-based delivery platforms for messenger RNA (mRNA) vaccines have gained significant attention in recent years. Nanoparticles have the advantages of enhancing immunogenicity, targeting delivery, and improving stability, providing a new solution for drug and vaccine delivery. In some clinical studies, a variety of nanoparticle delivery platforms have been gradually applied to a wide range of vaccine applications. Current research priorities are exploring various types of nanoparticles as vaccine delivery systems to enhance vaccin

APA, Harvard, Vancouver, ISO, and other styles

10

Pranali, Jadhav Pranali Hatwar Gajanan Sanap. "Review On Lipid Based Carrier As A Drug Delivery System." International Journal in Pharmaceutical Sciences 1, no. 12 (2023): 179–91. https://doi.org/10.5281/zenodo.10352354.

Full text

Abstract:

Lipid nanocarriers represent an alternative to polymeric nanoparticles, liposomes, and emulsions. Nanostructured Lipid Nanocarriers (NLCs), considered as the second-generation lipid carriers, aim to address the limitations of Solid Lipid Nanoparticles. They are employed across diverse therapeutic approaches and were initially designed for delivering lipophilic drugs, but their effectiveness with hydrophilic drugs is now well-established. The biocompatibility of lipids underpins their emergence as a promising avenue for drug delivery, exhibiting superior traits compared to other lipid formulati

APA, Harvard, Vancouver, ISO, and other styles

11

Zai, Khadijah. "Preparation of Solid Lipid Nanoparticle-Containing Ovalbumin Based Reverse Micelle-Double Emulsion Technique." Majalah Farmaseutik 19, no. 1 (2023): 43. http://dx.doi.org/10.22146/farmaseutik.v19i1.78283.

Full text

Abstract:

Encapsulation of protein in the lipid-based nanoparticle is quite challenging. A reverse micelle-double emulsion method could be used for answering this challenge because reverse micelles able to protect the polar core in a nonpolar solvent. Thus, the protein solution can be kept in the interior of the reverse micelle particle and hosted in a lipid matrix of nanoparticles. Herein, we describe the preparation of solid lipid nanoparticles (SLNp) for the encapsulation of ovalbumin (Ova) with reverse micelle-double emulsion. Using several combinations of solid lipids and phospholipids, we prepared

APA, Harvard, Vancouver, ISO, and other styles

12

Kim, Songhee, Boseung Choi, Yoojin Kim, and Gayong Shim. "Immune-Modulating Lipid Nanomaterials for the Delivery of Biopharmaceuticals." Pharmaceutics 15, no. 6 (2023): 1760. http://dx.doi.org/10.3390/pharmaceutics15061760.

Full text

Abstract:

In recent years, with the approval of preventative vaccines for pandemics, lipid nanoparticles have become a prominent RNA delivery vehicle. The lack of long-lasting effects of non-viral vectors is an advantage for infectious disease vaccines. With the introduction of microfluidic processes that facilitate the encapsulation of nucleic acid cargo, lipid nanoparticles are being studied as delivery vehicles for various RNA-based biopharmaceuticals. In particular, using microfluidic chip-based fabrication processes, nucleic acids such as RNA and proteins can be effectively incorporated into lipid

APA, Harvard, Vancouver, ISO, and other styles

13

Mehanna, Mohammed, Adel Motawaa, and Magda Samaha. "Pharmaceutical particulate carriers: Lipid - based carriers." National Journal of Physiology, Pharmacy and Pharmacology 2, no. 1 (2012): 10. https://doi.org/10.5455/njppp.2012.v2.i1.2.

Full text

Abstract:

Drug delivery research areas is continuously broaden and modified as a results of the realization of many factors (such as poor drug solubility and/or absorption, rapid metabolism, high fluctuation in the drug plasma level and variability) which play major role in adversely affecting in vivo results, in conventional drug delivery system. Lipids are one of the basic building blocks of biological membranes. Nanoscale-based delivery strategies are beginning to make a significant impact on global pharmaceutical planning and marketing. Among the approaches for exploiting nanotechnology developments

APA, Harvard, Vancouver, ISO, and other styles

14

Ahmad, Javed. "Lipid Nanoparticles Based Cosmetics with Potential Application in Alleviating Skin Disorders." Cosmetics 8, no. 3 (2021): 84. http://dx.doi.org/10.3390/cosmetics8030084.

Full text

Abstract:

The lipids mainly oils, fats, waxes and phospholipids are of substantial importance in the development and functioning of cosmetic products. The lipid nanoparticles-based cosmetic product is highly capable of protecting the skin against harmful radiations and is utilized for anti-aging therapy. Naturally derived antioxidants such as carotenoids, retinoids and tocopherols could be employed for their antioxidant properties as therapeutics and skincare active moieties in cosmetic products. Such a lipid nanoparticles-based cosmetic formulation consisting of antioxidants are very effective against

APA, Harvard, Vancouver, ISO, and other styles

15

Kim, Sungi, Namjun Kim, Jinyoung Seo, et al. "Nanoparticle-based computing architecture for nanoparticle neural networks." Science Advances 6, no. 35 (2020): eabb3348. http://dx.doi.org/10.1126/sciadv.abb3348.

Full text

Abstract:

The lack of a scalable nanoparticle-based computing architecture severely limits the potential and use of nanoparticles for manipulating and processing information with molecular computing schemes. Inspired by the von Neumann architecture (VNA), in which multiple programs can be operated without restructuring the computer, we realized the nanoparticle-based VNA (NVNA) on a lipid chip for multiple executions of arbitrary molecular logic operations in the single chip without refabrication. In this system, nanoparticles on a lipid chip function as the hardware that features memory, processors, an

APA, Harvard, Vancouver, ISO, and other styles

16

Faizan, Khan1 Surendra Dangi*2 Dr. Bhaskar Kumar Gupta3. "Review on Nanoparticle-Based Creams: Formulation, Characterization, and Applications in Therapeutics." International Journal of Pharmaceutical Sciences 3, no. 4 (2025): 3049–54. https://doi.org/10.5281/zenodo.15280634.

Full text

Abstract:

Nanoparticle-based creams have emerged as a promising advancement in the field of pharmaceutical and cosmetic formulations due to their ability to enhance drug delivery, improve skin penetration, and provide sustained release of active ingredients. This review explores the formulation strategies, characterization techniques, and therapeutic applications of nanoparticle creams. Various types of nanoparticles, including liposomes, solid lipid nanoparticles (SLNs), and polymeric nanoparticles, are discussed in terms of their advantages, challenges, and suitability for topical application. Additio

APA, Harvard, Vancouver, ISO, and other styles

17

Islam, Mohammad Ariful, Emma K. G. Reesor, Yingjie Xu, Harshal R. Zope, Bruce R. Zetter, and Jinjun Shi. "Biomaterials for mRNA delivery." Biomaterials Science 3, no. 12 (2015): 1519–33. http://dx.doi.org/10.1039/c5bm00198f.

Full text

Abstract:

Schematic representation of various biomaterial-based systems for mRNA delivery: (a) protamine–mRNA complex; (b) lipid nanoparticle; (c) lipid nanoparticle with inorganic compounds (e.g.apatite); (d) cationic polymeric nanoparticle; (e) lipid–polymer hybrid nanoparticles including (i) mRNA–polymer complex core surrounded by a lipid shell and (ii) polymer core surrounded by a lipid shell with mRNA absorbed onto the surface; and (f) gold nanoparticle.

APA, Harvard, Vancouver, ISO, and other styles

18

Silva, Ana Catarina, and José Manuel Sousa Lobo. "Preclinical Evaluation of Lipid-Based Nanosystems." Pharmaceutics 13, no. 5 (2021): 708. http://dx.doi.org/10.3390/pharmaceutics13050708.

Full text

Abstract:

The use of lipid-based nanosystems, including lipid nanoparticles (solid lipid nanoparticles—SLN, and nanostructured lipid carriers—NLC), nanoemulsions, and liposomes, among others, is widespread. [...]

APA, Harvard, Vancouver, ISO, and other styles

19

Streck, Sarah, Linda Hong, Ben J. Boyd, and Arlene McDowell. "Microfluidics for the Production of Nanomedicines: Considerations for Polymer and Lipid-based Systems." Pharmaceutical Nanotechnology 7, no. 6 (2019): 423–43. http://dx.doi.org/10.2174/2211738507666191019154815.

Full text

Abstract:

Background: Microfluidics is becoming increasingly of interest as a superior technique for the synthesis of nanoparticles, particularly for their use in nanomedicine. In microfluidics, small volumes of liquid reagents are rapidly mixed in a microchannel in a highly controlled manner to form nanoparticles with tunable and reproducible structure that can be tailored for drug delivery. Both polymer and lipid-based nanoparticles are utilized in nanomedicine and both are amenable to preparation by microfluidic approaches. Aim: Therefore, the purpose of this review is to collect the current state of

APA, Harvard, Vancouver, ISO, and other styles

20

Bala, Tripura Sundari I., and C. V. S. Subramanyam. "Formulation and Evaluation of Lipid Based Nanoparticles of Etravirine." Journal of Drug Delivery and Therapeutics 14, no. 1 (2024): 79–90. http://dx.doi.org/10.22270/jddt.v14i1.6373.

Full text

Abstract:

Engineered nanoparticles have the potential to revolutionize the diagnosis and treatment of many diseases like HIV/AIDS. Etravirine is one of the key components of highly active antiretroviral therapy used for the treatment of HIV-1 infections. The aim of the present study was to formulate and evaluate nanostructured lipid carriers of etravirine, intended for targeted delivery to macrophages, using solvent emulsification - evaporation technique. Estimates of drug solubility were employed for selection of solid lipids, liquid lipids and stabilizers for the preparation of NLCs. Design of experim

APA, Harvard, Vancouver, ISO, and other styles

21

Rajesh, Sharma, Neetesh Kumar Jain Dr., Nagar Deepika, Sachin Jain Dr., and Nagar Smita. "Chitosen based Nano structured Lipid Carrier of Acyclovir." Pharmaceutical and Chemical Journal 10, no. 1 (2023): 1–9. https://doi.org/10.5281/zenodo.13981847.

Full text

Abstract:

The investigation was to improve the bioavailability of acyclovir by incorporating it into solid lipid nanoparticles (SLNs) and chitosen nano structured lipid carriers (NLCs). The aim of present study is to develop chitosan nanoparticle formulation in order to achieve triggered release of anticancer drug encapsulated in chitosan nanoparticle. Evaluation for the potential of novel chitosan nanoparticle for enhanced cytotoxic effects and minimum side effects. The chitosan nanoparticle was prepared according to the ionic gelation method. Using TPP as cross linker with slight modification. After a

APA, Harvard, Vancouver, ISO, and other styles

22

Berger, Manon, Manon Degey, Jeanne Leblond Chain, et al. "Effect of PEG Anchor and Serum on Lipid Nanoparticles: Development of a Nanoparticles Tracking Method." Pharmaceutics 15, no. 2 (2023): 597. http://dx.doi.org/10.3390/pharmaceutics15020597.

Full text

Abstract:

Polyethylene glycol (PEG) is used in Lipid Nanoparticles (LNPs) formulations to confer stealth properties and is traditionally anchored in membranes by a lipid moiety whose length significantly impacts the LNPs fate in vivo. C18 acyl chains are efficiently anchored in the membrane, while shorter C14 lipids are quickly desorbed and replaced by a protein corona responsible for the completely different fate of LNPs. In this context, a method to predict the biological behavior of LNPs depending on the lipid-PEG dissociation was developed using the Nanoparticle Tracking Analysis (NTA) method in ser

APA, Harvard, Vancouver, ISO, and other styles

23

Lewis, Daniel R., Latrisha K. Petersen, Adam W. York, et al. "Sugar-based amphiphilic nanoparticles arrest atherosclerosis in vivo." Proceedings of the National Academy of Sciences 112, no. 9 (2015): 2693–98. http://dx.doi.org/10.1073/pnas.1424594112.

Full text

Abstract:

Atherosclerosis, the build-up of occlusive, lipid-rich plaques in arterial walls, is a focal trigger of chronic coronary, intracranial, and peripheral arterial diseases, which together account for the leading causes of death worldwide. Although the directed treatment of atherosclerotic plaques remains elusive, macrophages are a natural target for new interventions because they are recruited to lipid-rich lesions, actively internalize modified lipids, and convert to foam cells with diseased phenotypes. In this work, we present a nanomedicine platform to counteract plaque development based on tw

APA, Harvard, Vancouver, ISO, and other styles

24

Rehman, Mubashar, Nayab Tahir, Muhammad Farhan Sohail, et al. "Lipid-Based Nanoformulations for Drug Delivery: An Ongoing Perspective." Pharmaceutics 16, no. 11 (2024): 1376. http://dx.doi.org/10.3390/pharmaceutics16111376.

Full text

Abstract:

Oils and lipids help make water-insoluble drugs soluble by dispersing them in an aqueous medium with the help of a surfactant and enabling their absorption across the gut barrier. The emergence of microemulsions (thermodynamically stable), nanoemulsions (kinetically stable), and self-emulsifying drug delivery systems added unique characteristics that make them suitable for prolonged storage and controlled release. In the 1990s, solid-phase lipids were introduced to reduce drug leakage from nanoparticles and prolong drug release. Manipulating the structure of emulsions and solid lipid nanoparti

APA, Harvard, Vancouver, ISO, and other styles

25

Wang, Tianqi, Yusuke Suita, Saradha Miriyala, Jordan Dean, Nikos Tapinos, and Jie Shen. "Advances in Lipid-Based Nanoparticles for Cancer Chemoimmunotherapy." Pharmaceutics 13, no. 4 (2021): 520. http://dx.doi.org/10.3390/pharmaceutics13040520.

Full text

Abstract:

Nanomedicines have shown great potential in cancer therapy; in particular, the combination of chemotherapy and immunotherapy (namely chemoimmunotherapy) that is revolutionizing cancer treatment. Currently, most nanomedicines for chemoimmunotherapy are still in preclinical and clinical trials. Lipid-based nanoparticles, the most widely used nanomedicine platform in cancer therapy, is a promising delivery platform for chemoimmunotherapy. In this review, we introduce the commonly used immunotherapy agents and discuss the opportunities for chemoimmunotherapy mediated by lipid-based nanoparticles.

APA, Harvard, Vancouver, ISO, and other styles

26

Silva, Ana Catarina, João Nuno Moreira, and José Manuel Sousa Lobo. "Editorial—Current Insights on Lipid-Based Nanosystems." Pharmaceuticals 15, no. 10 (2022): 1267. http://dx.doi.org/10.3390/ph15101267.

Full text

Abstract:

Lipid-based nanosystems, including solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC), cationic lipid nanoparticles, nanoemulsions and liposomes, have been extensively studied to improve drug delivery through different administration routes [...]

APA, Harvard, Vancouver, ISO, and other styles

27

Agosti, Edoardo, Marco Zeppieri, Sara Antonietti, et al. "Navigating the Nose-to-Brain Route: A Systematic Review on Lipid-Based Nanocarriers for Central Nervous System Disorders." Pharmaceutics 16, no. 3 (2024): 329. http://dx.doi.org/10.3390/pharmaceutics16030329.

Full text

Abstract:

Background: The blood–brain barrier (BBB) regulates brain substance entry, posing challenges for treating brain diseases. Traditional methods face limitations, leading to the exploration of non-invasive intranasal drug delivery. This approach exploits the direct nose-to-brain connection, overcoming BBB restrictions. Intranasal delivery enhances drug bioavailability, reduces dosage, and minimizes systemic side effects. Notably, lipid nanoparticles, such as solid lipid nanoparticles and nanostructured lipid carriers, offer advantages like improved stability and controlled release. Their nanoscal

APA, Harvard, Vancouver, ISO, and other styles

28

Husnul Khotimah, Fathina Zahrani Rahmaniar, Fatimah Az Zahra, et al. "Unveiling the effects of nanoparticles-based antiepileptic drugs: Systematic review of in vivo studies." GSC Biological and Pharmaceutical Sciences 26, no. 3 (2024): 140–58. http://dx.doi.org/10.30574/gscbps.2024.26.3.0099.

Full text

Abstract:

Background: Resistance and side effects of antiepileptic drugs (AEDs) pose a challenge in epilepsy therapy due to the limited drug bioavailability in penetrating the Blood-Brain Barrier (BBB). Nanoparticles can be one solution by encapsulating AEDs to enhance drug distribution to target cells. This study systematically assesses 1) the characteristics of nanoparticles, and 2) the potential of nanoparticle AEDs in managing seizures in experimental animal models. Methods: This systematic literature review is limited to studies published between 2013 and July 2023 in the PubMed, ScienceDirect, Pro

APA, Harvard, Vancouver, ISO, and other styles

29

Husnul, Khotimah, Zahrani Rahmaniar Fathina, Az Zahra Fatimah, et al. "Unveiling the effects of nanoparticles-based antiepileptic drugs: Systematic review of in vivo studies." GSC Biological and Pharmaceutical Sciences 26, no. 3 (2024): 140–58. https://doi.org/10.5281/zenodo.11044802.

Full text

Abstract:

<strong>Background:</strong> Resistance and side effects of antiepileptic drugs (AEDs) pose a challenge in epilepsy therapy due to the limited drug bioavailability in penetrating the Blood-Brain Barrier (BBB). Nanoparticles can be one solution by encapsulating AEDs to enhance drug distribution to target cells. This study systematically assesses 1) the characteristics of nanoparticles, and 2) the potential of nanoparticle AEDs in managing seizures in experimental animal models. <strong>Methods:</strong> This systematic literature review is limited to studies published between 2013 and

APA, Harvard, Vancouver, ISO, and other styles

30

Seo, Jinyoung, Sungi Kim, Ha H. Park, Da Yeon Choi, and Jwa-Min Nam. "Nano-bio-computing lipid nanotablet." Science Advances 5, no. 2 (2019): eaau2124. http://dx.doi.org/10.1126/sciadv.aau2124.

Full text

Abstract:

Using nanoparticles as substrates for computation enables algorithmic and autonomous controls of their unique and beneficial properties. However, scalable architecture for nanoparticle-based computing systems is lacking. Here, we report a platform for constructing nanoparticle logic gates and circuits at the single-particle level on a supported lipid bilayer. Our “lipid nanotablet” platform, inspired by cellular membranes that are exploited to compartmentalize and control signaling networks, uses a lipid bilayer as a chemical circuit board and nanoparticles as computational units. On a lipid n

APA, Harvard, Vancouver, ISO, and other styles

31

Rajshri.R.Dusane, Yogeeta.S.Agrawal Sonia.M.Goyal Kalyani.A.Chaudhari. "A REVIEW ARTICLE ON NANOSTRUCTURED LIPID CARRIERS (NLCS) FOR DRUG DELIVERY AND TARGETING SYSTEM." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES o6, no. 05 (2019): 9568–77. https://doi.org/10.5281/zenodo.2819849.

Full text

Abstract:

<em>During the past decade, the number of studies describing nanostructured lipid carriers (NLC)-based formulations has been dramatically increased. The raise in NLC exploitation is essentially due to defeated barriers within the technological process of lipid-based nanoparticles’ formulation and increased knowledge of the underlying mechanisms of transport of NLC via different routes of administration. This review article aims to give an overview on the current state of the art of nanostructured lipid carriers as controlled drug delivery systems for future clinics through novel NLC appl

APA, Harvard, Vancouver, ISO, and other styles

32

Gyanani, Vijay, and Roshan Goswami. "Key Design Features of Lipid Nanoparticles and Electrostatic Charge-Based Lipid Nanoparticle Targeting." Pharmaceutics 15, no. 4 (2023): 1184. http://dx.doi.org/10.3390/pharmaceutics15041184.

Full text

Abstract:

Lipid nanoparticles (LNP) have gained much attention after the approval of mRNA COVID-19 vaccines. The considerable number of currently ongoing clinical studies are testament to this fact. These efforts towards the development of LNPs warrant an insight into the fundamental developmental aspects of such systems. In this review, we discuss the key design aspects that confer efficacy to a LNP delivery system, i.e., potency, biodegradability, and immunogenicity. We also cover the underlying considerations regarding the route of administration and targeting of LNPs to hepatic and non-hepatic targe

APA, Harvard, Vancouver, ISO, and other styles

33

Subhan, Md Abdus, Nina Filipczak, and Vladimir P. Torchilin. "Advances with Lipid-Based Nanosystems for siRNA Delivery to Breast Cancers." Pharmaceuticals 16, no. 7 (2023): 970. http://dx.doi.org/10.3390/ph16070970.

Full text

Abstract:

Breast cancer is the most frequently diagnosed cancer among women. Breast cancer is also the key reason for worldwide cancer-related deaths among women. The application of small interfering RNA (siRNA)-based drugs to combat breast cancer requires effective gene silencing in tumor cells. To overcome the challenges of drug delivery to tumors, various nanosystems for siRNA delivery, including lipid-based nanoparticles that protect siRNA from degradation for delivery to cancer cells have been developed. These nanosystems have shown great potential for efficient and targeted siRNA delivery to breas

APA, Harvard, Vancouver, ISO, and other styles

34

Nanda, Naimish, Chozharajan Tharmaraj, Saswati Panigrahi, and Mandadi Sandhya Rani. "Solid lipid Nanoparticles and Nanostructured Lipid Carrier: A Novel Approach for Lipid-Based Drug Delivery System." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 14, no. 02 (2024): 1232–38. http://dx.doi.org/10.25258/ijddt.14.2.90.

Full text

Abstract:

Lipid nanoparticles, or LNPs, including nanostructured lipid carriers (NLCs) and solid lipid nanoparticles (SLNs), attracted a lot of attention lately. SLNs were formed to circumvent the confines of the most common colloidal carriers because of their benefits, which include a favorable profile of release and precise administration of the drug with great physical stability. NLCs are the succeeding group of lipid nanoparticles with better capacity loading and durability. There are three possible NLC structural models. These LNPs may find usage in clinical medicine, research, cosmetics, and drug

APA, Harvard, Vancouver, ISO, and other styles

35

OM UDAY CHIDDARWAR, KASHISH DINESH JESWANI, DEEPAK S. MOHALE, and A. V. CHANDEWAR. "Nanoparticle-based drug delivery systems: An efficient system for the treatment of chronic diseases." World Journal of Biology Pharmacy and Health Sciences 20, no. 3 (2024): 358–74. https://doi.org/10.30574/wjbphs.2024.20.3.1038.

Full text

Abstract:

Nanoparticle-based drug delivery systems form an integral component in modern medicine since they respond to major problems undermining traditional pharmacotherapeutic techniques, such as poor bioavailability, toxicity, and poor targeting of the desired drug location. This review also looks into the different types of nanoparticles: liposomes, polymeric nanoparticles, dendrimers and solid lipid nanoparticles, and how they work such as: targeting, drug delivery, release of drug, and tissue penetration. Some of the FDA-approved drugs that incorporated nanotechnology are Doxil; Abraxane; Onivyde;

APA, Harvard, Vancouver, ISO, and other styles

36

Limaye, Akhilesh Dr. Shaikh Nasheer* Humnabade Shital Anantwal Akshat Babhulkar Akshay Joshi Maharudra Rajput Amrapali. "Comprehensive Review on Nanostructured Lipid Carriers." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 3423–31. https://doi.org/10.5281/zenodo.15474137.

Full text

Abstract:

Nanostructured lipid carriers (NLCs) represent a novel nanoparticulate drug delivery system composed of solid lipids, liquid lipids, emulsifying agents, and an aqueous phase. In recent years, NLCs have garnered considerable scientific and clinical interest due to their superior drug delivery capabilities, offering notable advantages over conventional dosage forms. Nanostructured lipid carriers (NLCs) are second generation lipid-based nanocarriers formulated using biocompatible solid lipids, liquid lipids, surfactants, and co-surfactants. These systems are capable of encapsulating a wide range

APA, Harvard, Vancouver, ISO, and other styles

37

Lohchania, Brijesh, Porkizhi Arjunan, Gokulnath Mahalingam, Abinaya Dandapani, Pankaj Taneja, and Srujan Marepally. "Lipid Nanoparticle-Mediated Liver-Specific Gene Therapy for Hemophilia B." Pharmaceutics 16, no. 11 (2024): 1427. http://dx.doi.org/10.3390/pharmaceutics16111427.

Full text

Abstract:

Background/Objectives: Hemophilia B is a hereditary bleeding disorder due to the production of liver malfunctional factor IX (FIX). Gene therapy with viral vectors offers a cure. However, applications are limited due to pre-existing antibodies, eligibility for children under 12 years of age, hepatotoxicity, and excessive costs. Lipid nanoparticles are a potential alternative owing to their biocompatibility, scalability, and non-immunogenicity. However, their therapeutic applications are still elusive due to the poor transfection efficiencies in delivering plasmid DNA into primary cells and tar

APA, Harvard, Vancouver, ISO, and other styles

38

Meanwell, Michael W., Connor O’Sullivan, Perry Howard, and Thomas M. Fyles. "Branched-chain and dendritic lipids for nanoparticles." Canadian Journal of Chemistry 95, no. 2 (2017): 120–29. http://dx.doi.org/10.1139/cjc-2016-0462.

Full text

Abstract:

Lipid nanoparticles (LNPs) for drug-delivery applications are largely derived from natural lipids. Synthetic lipids, particularly those incorporating branched hydrocarbons and hyper-branched hydrocarbon architectures, may afford enhanced lipophilicity with enhanced fluidity and thereby lead to LNP stabilization. Hydrocarbon anchors based on serinol diesters were prepared from linear Cn (n = 14, 16, 18) and branched (n = 16) acids with Boc-protected serinol. These diesters were further dimerized on an iminodiacetamide backbone to provide eight branched-chain and dendritic lipid anchors. Derivat

APA, Harvard, Vancouver, ISO, and other styles

39

Bova, Stefania, Serena Faggiano, Omar De Bei, et al. "Labeled Bovine Serum Albumin as a Fluorescent Biosensor to Monitor the Stability of Lipid-Based Formulations." Biosensors 15, no. 7 (2025): 425. https://doi.org/10.3390/bios15070425.

Full text

Abstract:

In the pharmaceutical field, lipid-based nanoparticles are extensively used for drug or vaccine delivery, particularly for treating respiratory disorders. However, their physico-chemical instability, particularly associated with lipid degradation through hydrolysis or oxidation, can affect their encapsulation properties. To monitor the stability of lipid-based formulations over time, we prepared acrylodan-labeled bovine serum albumin (here called albuminodan), and showed it is a fluorescent biosensor capable of concomitantly detect phospholipids as well as their degradation products, i.e., fat

APA, Harvard, Vancouver, ISO, and other styles

40

Veloso, Sérgio R. S., Joana F. G. Silva, Loic Hilliou, et al. "Impact of Citrate and Lipid-Functionalized Magnetic Nanoparticles in Dehydropeptide Supramolecular Magnetogels: Properties, Design and Drug Release." Nanomaterials 11, no. 1 (2020): 16. http://dx.doi.org/10.3390/nano11010016.

Full text

Abstract:

Currently, the nanoparticle functionalization effect on supramolecular peptide-based hydrogels remains undescribed, but is expected to affect the hydrogels’ self-assembly and final magnetic gel properties. Herein, two different functionalized nanoparticles: citrate-stabilized (14.4 ± 2.6 nm) and lipid-coated (8.9 ± 2.1 nm) magnetic nanoparticles, were used for the formation of dehydropeptide-based supramolecular magnetogels consisting of the ultra-short hydrogelator Cbz-L-Met-Z-ΔPhe-OH, with an assessment of their effect over gel properties. The lipid-coated nanoparticles were distributed alon

APA, Harvard, Vancouver, ISO, and other styles

41

González-Fernández, Felipe M., Annalisa Bianchera, Paolo Gasco, Sara Nicoli, and Silvia Pescina. "Lipid-Based Nanocarriers for Ophthalmic Administration: Towards Experimental Design Implementation." Pharmaceutics 13, no. 4 (2021): 447. http://dx.doi.org/10.3390/pharmaceutics13040447.

Full text

Abstract:

Nanotherapeutics based on biocompatible lipid matrices allow for enhanced solubility of poorly soluble compounds in the treatment of ophthalmic diseases, overcoming the anatomical and physiological barriers present in the eye, which, despite the ease of access, remains strongly protected. Micro-/nanoemulsions, solid lipid nanoparticles (SLN) or nanostructured lipid carriers (NLC) combine liquid and/or solid lipids with surfactants, improving drug stability and ocular bioavailability. Current research and development approaches based on try-and-error methodologies are unable to easily fine-tune

APA, Harvard, Vancouver, ISO, and other styles

42

Queiroz, Marjorie de Carvalho Vieira, and Luís Alexandre Muehlmann. "Characteristics and Preparation of Solid Lipid Nanoparticles and Nanostructured Lipid Carriers." Journal of Nanotheranostics 5, no. 4 (2024): 188–211. http://dx.doi.org/10.3390/jnt5040012.

Full text

Abstract:

Solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) have emerged as promising systems for delivering active ingredients. They are derived from physiological, biodegradable, and biocompatible lipids, offering benefits such as sustained release promotion and increased drug stability. These systems are apt for the efficient transport of therapeutic drugs to target tissues while also providing advantages such as facilitating large-scale industrial production, bioavailability, and protection against degradation. The preparation of these nanoparticles involves utilizing diverse

APA, Harvard, Vancouver, ISO, and other styles

43

Musielak, Ewelina, Agnieszka Feliczak-Guzik, and Izabela Nowak. "Synthesis and Potential Applications of Lipid Nanoparticles in Medicine." Materials 15, no. 2 (2022): 682. http://dx.doi.org/10.3390/ma15020682.

Full text

Abstract:

Currently, carriers of active ingredients in the form of particles of a size measured in nanometers are the focus of interest of research centers worldwide. So far, submicrometer emulsions, liposomes, as well as microspheres, and nanospheres made of biodegradable polymers have been used in medicine. Recent studies show particular interest in nanoparticles based on lipids, and at the present time, are even referred to as the “era of lipid carriers”. With the passage of time, lipid nanoparticles of the so-called first and second generation, SLN (Solid Lipid Nanoparticles) and nanostructured lipi

APA, Harvard, Vancouver, ISO, and other styles

44

Dąbrowska, Marta, and Izabela Nowak. "Lipid Nanoparticles Loaded with Selected Iridoid Glycosides as Effective Components of Hydrogel Formulations." Materials 14, no. 15 (2021): 4090. http://dx.doi.org/10.3390/ma14154090.

Full text

Abstract:

One possibility of improving active ingredient penetration into deeper skin layers to enhance the cosmetic product effectiveness, is the application of lipid nanoparticles. The aim of the study presented in this paper was to evaluate the potential of hydrogel formulations enriched with iridoid glycosides-loaded lipid nanoparticles. Lipid nanocarriers were produced using an emulsification-ultrasonication method based on multiple emulsions. The encapsulation efficiency was determined at the level of 89% and 77% for aucubin and catalpol, respectively. The next stage was the incorporation of the o

APA, Harvard, Vancouver, ISO, and other styles

45

Onteru Sujeevan. "Lipid-based nanoparticles and their recent advances." GSC Advanced Research and Reviews 18, no. 3 (2024): 182–88. http://dx.doi.org/10.30574/gscarr.2024.18.3.0096.

Full text

Abstract:

Lipid-based nanoparticles hold great potential for drug delivery, providing biocompatibility and the ability to encapsulate both hydrophilic and hydrophobic drugs. However, there are certain challenges associated with small molecules, such as leakage and premature release, which can compromise their effectiveness. Despite these challenges, lipid nanoparticles offer advantages in terms of solubility, stability, and targeted delivery, thereby reducing side effects. Additionally, they can be customized for specific molecules, ensuring biocompatibility and biodegradability. While complications may

APA, Harvard, Vancouver, ISO, and other styles

46

Vinayak, Kachru Mhaismale Dhanshri Baburao Panchal Pande Prajakta Rajendra Pathade Gayatri Pramod Patil Siddhesh Gopal. "Nanostructured Lipid Carriers." International Journal in Pharmaceutical Sciences 2, no. 8 (2024): 3947–62. https://doi.org/10.5281/zenodo.13501342.

Full text

Abstract:

At present, nanotechnology is widely utilized in drug delivery, facilitating both passive and active targeting through various administration routes. Solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) are the two primary types of lipid-based nanoparticles. Muller developed the NLCs in 1999-2000. NLCs come in three different forms: Imperfect, Amorphous and Multiple. Compared to SLNs, NLCs have a greater drug loading efficiency because their partially crystalline lipid system is created by blending liquid and solid lipids. Various excipients are used in formulating NLCs ar

APA, Harvard, Vancouver, ISO, and other styles

47

Vinayak, Kachru Mhaismale Dhanshri Baburao Panchal Pande Prajakta Rajendra Pathade Gayatri Pramod Patil Siddhesh Gopal. "Nanostructured Lipid Carriers." International Journal in Pharmaceutical Sciences 2, no. 8 (2024): 3947–62. https://doi.org/10.5281/zenodo.13501342.

Full text

Abstract:

At present, nanotechnology is widely utilized in drug delivery, facilitating both passive and active targeting through various administration routes. Solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) are the two primary types of lipid-based nanoparticles. Muller developed the NLCs in 1999-2000. NLCs come in three different forms: Imperfect, Amorphous and Multiple. Compared to SLNs, NLCs have a greater drug loading efficiency because their partially crystalline lipid system is created by blending liquid and solid lipids. Various excipients are used in formulating NLCs ar

APA, Harvard, Vancouver, ISO, and other styles

48

Vinayak, Kachru Mhaismale Dhanshri Baburao Panchal Pande Prajakta Rajendra Pathade Gayatri Pramod Patil Siddhesh Gopal. "Nanostructured Lipid Carriers." International Journal in Pharmaceutical Sciences 2, no. 8 (2024): 3947–62. https://doi.org/10.5281/zenodo.13501342.

Full text

Abstract:

At present, nanotechnology is widely utilized in drug delivery, facilitating both passive and active targeting through various administration routes. Solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) are the two primary types of lipid-based nanoparticles. Muller developed the NLCs in 1999-2000. NLCs come in three different forms: Imperfect, Amorphous and Multiple. Compared to SLNs, NLCs have a greater drug loading efficiency because their partially crystalline lipid system is created by blending liquid and solid lipids. Various excipients are used in formulating NLCs ar

APA, Harvard, Vancouver, ISO, and other styles

49

Vinayak, Kachru Mhaismale Dhanshri Baburao Panchal Pande Prajakta Rajendra Pathade Gayatri Pramod Patil Siddhesh Gopal. "Nanostructured Lipid Carriers." International Journal in Pharmaceutical Sciences 2, no. 8 (2024): 3947–62. https://doi.org/10.5281/zenodo.13501342.

Full text

Abstract:

At present, nanotechnology is widely utilized in drug delivery, facilitating both passive and active targeting through various administration routes. Solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) are the two primary types of lipid-based nanoparticles. Muller developed the NLCs in 1999-2000. NLCs come in three different forms: Imperfect, Amorphous and Multiple. Compared to SLNs, NLCs have a greater drug loading efficiency because their partially crystalline lipid system is created by blending liquid and solid lipids. Various excipients are used in formulating NLCs ar

APA, Harvard, Vancouver, ISO, and other styles

50

Creteanu, Andreea, Gabriela Lisa, Cornelia Vasile, Maria-Cristina Popescu, Adrian Florin Spac, and Gladiola Tantaru. "Development of Solid Lipid Nanoparticles for Controlled Amiodarone Delivery." Methods and Protocols 6, no. 5 (2023): 97. http://dx.doi.org/10.3390/mps6050097.

Full text

Abstract:

In various drug delivery systems, solid lipid nanoparticles are dominantly lipid-based nanocarriers. Amiodarone hydrochloride is an antiarrhythmic agent used to treat severe rhythm disturbances. It has variable and hard-to-predict absorption in the gastrointestinal tract because of its low solubility and high permeability. The aims of this study were to improve its solubility by encapsulating amiodarone into solid lipid nanoparticles using two excipients—Compritol® 888 ATO (pellets) (C888) as a lipid matrix and Transcutol® (T) as a surfactant. Six types of amiodarone-loaded solid lipid nanopar

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!