Relevant bibliographies by topics / Lipid-bilayer insertion

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  1. Journal articles
  2. Dissertations / Theses
  3. Book chapters
  4. Conference papers

Academic literature on the topic 'Lipid-bilayer insertion'

Author: Grafiati
Published: 25 May 2024
Last updated: 31 July 2025

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Journal articles on the topic "Lipid-bilayer insertion"

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Khalid, Syma, Peter J. Bond, John Holyoake, Robert W. Hawtin, and Mark S. P. Sansom. "DNA and lipid bilayers: self-assembly and insertion." Journal of The Royal Society Interface 5, suppl_3 (2008): 241–50. http://dx.doi.org/10.1098/rsif.2008.0239.focus.

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DNA–lipid complexes are of biomedical importance as delivery vectors for gene therapy. To gain insight into the interactions of DNA with zwitterionic and cationic (dimyristoyltrimethylammonium propane (DMTAP)) lipids, we have used coarse-grained molecular dynamics simulations to study the self-assembly of DPPC and DPPC/DMTAP lipid bilayers in the presence of a DNA dodecamer. We observed the spontaneous formation of lipid bilayers from initial systems containing randomly placed lipids, water–counterions and DNA. In both the DPPC and DPPC/DMTAP simulations, the DNA molecule is located at the wat
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Slaybaugh, Gregory, Dhammika Weerakkody, Donald M. Engelman, Oleg A. Andreev, and Yana K. Reshetnyak. "Kinetics of pHLIP peptide insertion into and exit from a membrane." Proceedings of the National Academy of Sciences 117, no. 22 (2020): 12095–100. http://dx.doi.org/10.1073/pnas.1917857117.

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To advance mechanistic understanding of membrane-associated peptide folding and insertion, we have studied the kinetics of three single tryptophan pHLIP (pH-Low Insertion Peptide) variants, where tryptophan residues are located near the N terminus, near the middle, and near the inserting C-terminal end of the pHLIP transmembrane helix. Single-tryptophan pHLIP variants allowed us to probe different parts of the peptide in the pathways of peptide insertion into the lipid bilayer (triggered by a pH drop) and peptide exit from the bilayer (triggered by a rise in pH). By using pH jumps of different
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SHEPHERD, Craig M., Hans J. VOGEL, and D. Peter TIELEMAN. "Interactions of the designed antimicrobial peptide MB21 and truncated dermaseptin S3 with lipid bilayers: molecular-dynamics simulations." Biochemical Journal 370, no. 1 (2003): 233–43. http://dx.doi.org/10.1042/bj20021255.

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Molecular-dynamics simulations covering 30ns of both a natural and a synthetic antimicrobial peptide in the presence of a zwitterionic lipid bilayer were performed. In both simulations, copies of the peptides were placed in an α-helical conformation on either side of the bilayer about 10Å (1Å = 0.1nm) from the interface, with either the hydrophobic or the positively charged face of the helix directed toward the bilayer surface. The degree of peptide—lipid interaction was dependent on the starting configuration: surface binding and subsequent penetration of the bilayer was observed for the hydr
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Reshetnyak, Yana K., Oleg A. Andreev, Michael Segala, Vladislav S. Markin, and Donald M. Engelman. "Energetics of peptide (pHLIP) binding to and folding across a lipid bilayer membrane." Proceedings of the National Academy of Sciences 105, no. 40 (2008): 15340–45. http://dx.doi.org/10.1073/pnas.0804746105.

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The pH low-insertion peptide (pHLIP) serves as a model system for peptide insertion and folding across a lipid bilayer. It has three general states: (I) soluble in water or (II) bound to the surface of a lipid bilayer as an unstructured monomer, and (III) inserted across the bilayer as a monomeric α-helix. We used fluorescence spectroscopy and isothermal titration calorimetry to study the interactions of pHLIP with a palmitoyloleoylphosphatidylcholine (POPC) lipid bilayer and to calculate the transition energies between states. We found that the Gibbs free energy of binding to a POPC surface a
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Salvador-Castell, Marta, Nicholas J. Brooks, Roland Winter, Judith Peters, and Philippe M. Oger. "Non-Polar Lipids as Regulators of Membrane Properties in Archaeal Lipid Bilayer Mimics." International Journal of Molecular Sciences 22, no. 11 (2021): 6087. http://dx.doi.org/10.3390/ijms22116087.

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The modification of archaeal lipid bilayer properties by the insertion of apolar molecules in the lipid bilayer midplane has been proposed to support cell membrane adaptation to extreme environmental conditions of temperature and hydrostatic pressure. In this work, we characterize the insertion effects of the apolar polyisoprenoid squalane on the permeability and fluidity of archaeal model membrane bilayers, composed of lipid analogues. We have monitored large molecule and proton permeability and Laurdan generalized polarization from lipid vesicles as a function of temperature and hydrostatic
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Yue, Tongtao, Mingbin Sun, Shuai Zhang, Hao Ren, Baosheng Ge, and Fang Huang. "How transmembrane peptides insert and orientate in biomembranes: a combined experimental and simulation study." Physical Chemistry Chemical Physics 18, no. 26 (2016): 17483–94. http://dx.doi.org/10.1039/c6cp01133k.

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Jo, Euijung, Jack Blazyk, and Joan M. Boggs. "Insertion of Magainin into the Lipid Bilayer Detected Using Lipid Photolabels†." Biochemistry 37, no. 39 (1998): 13791–99. http://dx.doi.org/10.1021/bi980855c.

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Hyland, Caroline, Laurent Vuillard, Colin Hughes, and Vassilis Koronakis. "Membrane Interaction of Escherichia coliHemolysin: Flotation and Insertion-Dependent Labeling by Phospholipid Vesicles." Journal of Bacteriology 183, no. 18 (2001): 5364–70. http://dx.doi.org/10.1128/jb.183.18.5364-5370.2001.

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ABSTRACT The 1,024-amino-acid acylated hemolysin of Escherichia coli subverts host cell functions and causes cell lysis. Both activities require insertion of the toxin into target mammalian cell membranes. To identify directly the principal toxin sequences dictating membrane binding and insertion, we assayed the lipid bilayer interaction of native protoxin, stably active toxin, and recombinant peptides. Binding was assessed by flotation of protein-liposome mixtures through density gradients, and insertion was assessed by labeling with a photoactivatable probe incorporated into the target lipid
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Weerakkody, Dhammika, Oleg A. Andreev, and Yana K. Reshetnyak. "Insertion into lipid bilayer of truncated pHLIP ® peptide." Biochemistry and Biophysics Reports 8 (December 2016): 290–95. http://dx.doi.org/10.1016/j.bbrep.2016.10.001.

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Takahashi, Akira, Chiyo Yamamoto, Toshio Kodama, et al. "Pore Formation of Thermostable Direct Hemolysin Secreted from Vibrio parahaemolyticus in Lipid Bilayers." International Journal of Toxicology 25, no. 5 (2006): 409–18. http://dx.doi.org/10.1080/10915810600868181.

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Vibrio parahaemolyticus secretes thermostable direct hemolysin (TDH), a major virulence factor. Earlier studies report that TDH is a pore-forming toxin. However, the characteristics of pores formed by TDH in the lipid bilayer, which is permeable to small ions, remain to be elucidated. Ion channel-like activities were observed in lipid bilayers containing TDH. Three types of conductance were identified. All the channels displayed relatively low ion selectivity, and similar ion permeability. The Cl− channel inhibitors, DIDS, glybenclamide, and NPPB, did not affect the channel activity of pores f
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Dissertations / Theses on the topic "Lipid-bilayer insertion"

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Johansson, Anna CV. "Solvation properties of proteins in membranes." Doctoral thesis, Stockholms universitet, Institutionen för biokemi och biofysik, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-27437.

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Knowledge about the insertion and stabilization of membrane proteins is a key step towards understanding their function and enabling membrane protein design. Transmembrane helices are normally quite hydrophobic to insert efficiently, but there are many exceptions with unfavorable polar or titratable residues. Since evolutionary conserved these amino acids are likely of paramount functional importance, e.g. the four arginines in the S4 voltage sensor helix of voltage-gated ion channels. This has lead to vivid discussion about their conformation, protonation state and cost of insertion. To addre
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Lanrezac, André. "Interprétation de données expérimentales par simulation et visualisation moléculaire interactive." Electronic Thesis or Diss., Université Paris Cité, 2023. http://www.theses.fr/2023UNIP7133.

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L'objectif de l'approche des simulations moléculaires interactive (Interactive Molecular Simulations - IMS) est d'observer en direct la dynamique conformationnelle d'une simulation moléculaire en cours. Le retour visuel instantané permet un suivi instructif ainsi que l'observation des changements structurels imposés par la manipulation de l'IMS par l'utilisateur. J'ai mené une étude approfondie des connaissances pour rassembler et synthétiser l'ensemble des recherches qui ont développé l'IMS. La dynamique moléculaire interactive (Interactive Molecular Dynamics - IMD) est l'un des premiers prot
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Book chapters on the topic "Lipid-bilayer insertion"

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Shoji, Kan. "De-Insertion Current Analysis of Pore-Forming Peptides and Proteins Using Gold Electrode-Supported Lipid Bilayer." In Methods in Molecular Biology. Springer US, 2021. http://dx.doi.org/10.1007/978-1-0716-1843-1_8.

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Alobeedallah, Hadeel, Bruce A. Cornell, and Hans Coster. "Measuring Voltage–Current Characteristics of Tethered Bilayer Lipid Membranes to Determine the Electro-Insertion Properties of Analytes." In Methods in Molecular Biology. Springer US, 2021. http://dx.doi.org/10.1007/978-1-0716-1843-1_5.

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Eisenhawer, Martin, Mark Soekaijo, Andreas Kuhn, and Horst Vogel. "Thermodynamics of the membrane insertion process of the M13 procoat protein, a lipid bilayer traversing protein comprising a leader sequence." In Molecular Dynamics of Biomembranes. Springer Berlin Heidelberg, 1996. http://dx.doi.org/10.1007/978-3-642-61126-1_9.

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Ulmschneider, Jakob. "New Insights into the Peptide–Membrane Partitioning Equilibrium from In Silico Free Surface-to-Bilayer Peptide Insertion." In Liposomes, Lipid Bilayers and Model Membranes. CRC Press, 2014. http://dx.doi.org/10.1201/b16617-7.

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Conference papers on the topic "Lipid-bilayer insertion"

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Taylor, Graham, Donald Leo, and Andy Sarles. "Detection of Botulinum Neurotoxin/A Insertion Using an Encapsulated Interface Bilayer." In ASME 2012 Conference on Smart Materials, Adaptive Structures and Intelligent Systems. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/smasis2012-8101.

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Many signaling mechanisms in living cells occur at biological boundaries via cell surface receptors and membrane proteins embedded in lipid bilayers. The coordination of actions of sensory and motor neurons in the nervous system represents one example of many that heavily depends on lipid membrane bound receptor mediated signaling. As a result, chemical and biological toxins that disrupt these neural signals can have severe physiological effects, including paralysis and death. Botulinum neurotoxin Type A (BoNT/A) is a proteolytic toxin that inserts through vesicle membranes and cleaves membran
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Maftouni, Negin, Mehriar Amininasab, MohammadReza Ejtehadi, and Farshad Kowsari. "Multiscale Molecular Dynamics Simulation of Nanobio Membrane in Interaction With Protein." In ASME 2013 2nd Global Congress on NanoEngineering for Medicine and Biology. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/nemb2013-93054.

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One of the most important biological components is lipid nanobio membrane. The lipid membranes of alive cells and their mechanical properties play an important role in biophysical investigations. Some proteins affect the shape and properties of the nanobio membrane while interacting with it. In this study a multiscale approach is experienced: first a 100ns all atom (fine-grained) molecular dynamics simulation is done to investigate the binding of CTX A3, a protein from snake venom, to a phosphatidylcholine lipid bilayer, second, a 5 micro seconds coarse-grained molecular dynamics simulation is
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Nguyen, Mary-Anne, and Stephen A. Sarles. "Microfluidic Generation, Encapsulation and Characterization of Asymmetric Droplet Interface Bilayers." In ASME 2016 Conference on Smart Materials, Adaptive Structures and Intelligent Systems. American Society of Mechanical Engineers, 2016. http://dx.doi.org/10.1115/smasis2016-9034.

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Our research focuses on creating smart materials that utilize synthetic cell membranes assembled at liquid interfaces for autonomic sensing, actuation, and energy conversion. Unlike single membrane assemblies, systems featuring many membranes have the potential to offer multi-functionality, greater transduction sensitivity, and even emergent behaviors in response to environmental stimuli, similar to living tissue, which utilizes networks of highly packed cells to accomplish tasks. Here, we present for the first time a novel microfluidic platform capable of generating a stream of alternating dr
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Maftouni, Negin, M. Amininasab, and Farshad Kowsari. "Molecular Dynamics Study of Nanobio Membranes." In ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology. ASMEDC, 2010. http://dx.doi.org/10.1115/nemb2010-13277.

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Molecular models of lipid bilayers have ignored the interface of two monolayers of nanobiomembranes in detail by now, however in this paper a new physical model is proposed based on variation of surface tension in the interface of two monolayers of membrane. Experimental results have shown that some peptides and proteins like antimicrobial peptides and cytotoxins are able to change the shape of — or in some cases to destroy — the bilayer membrane during insertion to external monolayer. All interfaces in nanobiomembrane are liquid-liquid type. In this paper appropriate ensembles to simulate liq
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Sarles, Stephen A., Kevin L. Garrison, Taylor T. Young, and Donald J. Leo. "Formation and Encapsulation of Biomolecular Arrays for Developing Arrays of Membrane-Based Artificial Hair Cell Sensors." In ASME 2011 Conference on Smart Materials, Adaptive Structures and Intelligent Systems. ASMEDC, 2011. http://dx.doi.org/10.1115/smasis2011-5095.

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Recent research in our group has shown that artificial cell membranes formed at the base of a hair-like structure can be used to sense air flow in a manner similar to the mechanotransduction processes found in mammalian hair cells. Our previous work demonstrated that a single artificial hair cell can be formed in an open substrate. However, that study also motivated the need to develop fully-encapsulated devices that feature arrays of hair-cells. Since the transduction element in this concept is an artificial cell membrane, or lipid bilayer, this work investigates two parallel substrate design
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Matsuo, Taisuke, Takenori Yamamoto, Kanami Niiyama, et al. "Design, preparation and directional insertion of peptides into lipid bilayer membrane and their application for the preparation of liposome of which surface could be coated by externally added antibody." In 2007 International Symposium on Micro-NanoMechatronics and Human Science. IEEE, 2007. http://dx.doi.org/10.1109/mhs.2007.4420829.

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Najem, Joseph S., Graham J. Taylor, Charles P. Collier, and Stephen A. Sarles. "Synapse-Inspired Variable Conductance in Biomembranes: A Preliminary Study." In ASME 2017 Conference on Smart Materials, Adaptive Structures and Intelligent Systems. American Society of Mechanical Engineers, 2017. http://dx.doi.org/10.1115/smasis2017-3820.

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Memristors are solid-state devices that exhibit voltage-controlled conductance. This tunable functionality enables the implementation of biologically-inspired synaptic functions in solid-state neuromorphic computing systems. However, while memristors are meant to emulate an intricate signal transduction process performed by soft biomolecular structures, they are commonly constructed from silicon- or polymer-based materials. As a result, the volatility, intricate design, and high-energy resistance switching in memristive devices, usually, leads to energy consumption in memristors that is severa
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