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Relevant bibliographies by topics / Lipid bilayer membranes

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Academic literature on the topic 'Lipid bilayer membranes'

Author: Grafiati

Published: 4 June 2021

Last updated: 19 February 2022

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Journal articles on the topic "Lipid bilayer membranes"

1

Thompson, J. E., C. D. Froese, Y. Hong, K. A. Hudak, and M. D. Smith. "Membrane deterioration during senescence." Canadian Journal of Botany 75, no. 6 (June 1, 1997): 867–79. http://dx.doi.org/10.1139/b97-096.

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The lipid bilayers of plant membranes are normally liquid crystalline, reflecting the inherent rotational motion of membrane fatty acids at physiological temperature. With the onset of senescence, the chemical composition of membrane lipids changes resulting in lipid phase separations within the bilayer. These phase changes render the membranes leaky and lead to loss of essential ion gradients and impairment of cell function. The separation of lipid phases appears to be attributable to an accumulation of lipid metabolites in the bilayer that are formed during turnover and metabolism of membrane lipids. These metabolites are normally released from membranes as lipid–protein particles found in the cell cytosol and within organelles. The lipid–protein particles also contain catabolites of membrane proteins and appear to serve as a vehicle for removing lipid and protein metabolites that would otherwise destabilize the bilayer. They bear structural resemblance to oil bodies, which are abundant in oil seeds, and have been found in leaves, cotyledons, and petals as well as in insect and animal tissue. The accumulation of lipid metabolites in senescing membranes and ensuing separation of lipid phases appear to reflect impairment of lipid–protein particle release from membranes as tissues age and to be a seminal cause of membrane dysfunction with advancing senescence. Key words: lipid bilayer, lipid phase separation, lipid–protein particles, membrane, oil body, senescence.

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Maček Lebar, Alenka, Damijan Miklavčič, Malgorzata Kotulska, and Peter Kramar. "Water Pores in Planar Lipid Bilayers at Fast and Slow Rise of Transmembrane Voltage." Membranes 11, no. 4 (April 5, 2021): 263. http://dx.doi.org/10.3390/membranes11040263.

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Basic understanding of the barrier properties of biological membranes can be obtained by studying model systems, such as planar lipid bilayers. Here, we study water pores in planar lipid bilayers in the presence of transmembrane voltage. Planar lipid bilayers were exposed to fast and slow linearly increasing voltage and current signals. We measured the capacitance, breakdown voltage, and rupture time of planar lipid bilayers composed of 1-pamitoyl 2-oleoyl phosphatidylcholine (POPC), 1-pamitoyl 2-oleoyl phosphatidylserine (POPS), and a mixture of both lipids in a 1:1 ratio. Based on the measurements, we evaluated the change in the capacitance of the planar lipid bilayer corresponding to water pores, the radius of water pores at membrane rupture, and the fraction of the area of the planar lipid bilayer occupied by water pores.planar lipid bilayer capacitance, which corresponds to water pores, water pore radius at the membrane rupture, and a fraction of the planar lipid bilayer area occupied by water pores. The estimated pore radii determining the rupture of the planar lipid bilayer upon fast build-up of transmembrane voltage are 0.101 nm, 0.110 nm, and 0.106 nm for membranes composed of POPC, POPS, and POPC:POPS, respectively. The fraction of the surface occupied by water pores at the moment of rupture of the planar lipid bilayer The fraction of an area that is occupied by water pores at the moment of planar lipid bilayer rupture is in the range of 0.1–1.8%.

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Petelska, Aneta. "Interfacial tension of bilayer lipid membranes." Open Chemistry 10, no. 1 (February 1, 2012): 16–26. http://dx.doi.org/10.2478/s11532-011-0130-7.

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AbstractInterfacial tension is an important characteristic of a biological membrane because it determines its rigidity, thus affecting its stability. It is affected by factors such as medium pH and by the presence of certain substances, for example cholesterol, other lipids, fatty acids, amines, amino acids, or proteins, incorporated in the lipid bilayer. Here, the effects of various parameters to on interfacial tension values of bilayer lipid membranes are discussed.The mathematically derived and experimentally confirmed results presented in this paper are of importance to the interpretation of phenomena occurring in lipid bilayers. These results can lead to a better understanding of the physical properties of biological membranes. The simple interfacial tension method proposed herein may be successfully used to determine the interfacial tension values of 1:1 lipid-lipid, lipid-cholesterol, lipid-fatty acid, lipid-amine, and lipid-amino acid systems.

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Amador, Guillermo J., Dennis van Dijk, Roland Kieffer, Marie-Eve Aubin-Tam, and Daniel Tam. "Hydrodynamic shear dissipation and transmission in lipid bilayers." Proceedings of the National Academy of Sciences 118, no. 21 (May 21, 2021): e2100156118. http://dx.doi.org/10.1073/pnas.2100156118.

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Vital biological processes, such as trafficking, sensing, and motility, are facilitated by cellular lipid membranes, which interact mechanically with surrounding fluids. Such lipid membranes are only a few nanometers thick and composed of a liquid crystalline structure known as the lipid bilayer. Here, we introduce an active, noncontact, two-point microrheology technique combining multiple optical tweezers probes with planar freestanding lipid bilayers accessible on both sides. We use the method to quantify both fluid slip close to the bilayer surface and transmission of fluid flow across the structure, and we use numerical simulations to determine the monolayer viscosity and the intermonolayer friction. We find that these physical properties are highly dependent on the molecular structure of the lipids in the bilayer. We compare ordered-phase with liquid disordered-phase lipid bilayers, and we find the ordered-phase bilayers to be 10 to 100 times more viscous but with 100 times less intermonolayer friction. When a local shear is applied by the optical tweezers, the ultralow intermonolayer friction results in full slip of the two leaflets relative to each other and as a consequence, no shear transmission across the membrane. Our study sheds light on the physical principles governing the transfer of shear forces by and through lipid membranes, which underpin cell behavior and homeostasis.

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Macdonald, Peter M., Kevin J. Crowell, Carla M. Franzin, Peter Mitrakos, and Darlene J. Semchyschyn. "Polyelectrolyte-induced domains in lipid bilayer membranes: the deuterium NMR perspective." Biochemistry and Cell Biology 76, no. 2-3 (May 1, 1998): 452–64. http://dx.doi.org/10.1139/o98-044.

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Domain formation in lipid bilayer membranes can occur through electrostatic interactions between charged lipids and oppositely charged polyelectrolytes, such as proteins or polynucleic acids. This review describes a novel method for examining such domains in lipid bilayers, based on 2H NMR spectroscopy. The 2H NMR spectrum of choline-deuterated phosphatidylcholine is sensitive to, and reports on, lipid bilayer surface charge. When a charged lipid bilayer is exposed to an oppositely charged polyelectrolyte, the latter binds electrostatically to the bilayer surface and attracts charged lipids into its vicinity. The resulting inhomogeneous charge distribution produces overlapping 2H NMR subspectra arising from phosphatidylcholine within charge-enriched versus charge-depleted regions. Such spectral details as the quadrupolar splittings and the relative intensities of the subspectra permit a complete analysis of the domain composition, size, and, within limits, lifetime. Using 2H NMR, domain formation in lipid bilayer membranes can be observed with both cationic and anionic polyelectrolytes, whether of natural or synthetic origin. Domain size and composition prove to be sensitive to the detailed chemical structure of both the polyelectrolyte and the charged lipids. Within the domains there is always a stoichiometric anion/cation binding ratio, indicating that the polyelectrolyte lies flat on the membrane surface. The amount of phosphatidylcholine within the domain varies as a function of its statistical availability, in accordance with the predictions of a recent thermodynamic model of domain formation. When the molecular weight of the polyelectrolyte is varied, the domain size alters in accordance with the predictions of classical polymer physics. As expected for a predominantly electrostatic phenomenon, the observed domains dissipate at high ionic strength.Key words: electrostatic domains, polyelectrolytes, lipid bilayers, deuterium NMR.

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Ouberai, Myriam M., Juan Wang, Marcus J. Swann, Celine Galvagnion, Tim Guilliams, Christopher M. Dobson, and Mark E. Welland. "α-Synuclein Senses Lipid Packing Defects and Induces Lateral Expansion of Lipids Leading to Membrane Remodeling." Journal of Biological Chemistry 288, no. 29 (June 5, 2013): 20883–95. http://dx.doi.org/10.1074/jbc.m113.478297.

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There is increasing evidence for the involvement of lipid membranes in both the functional and pathological properties of α-synuclein (α-Syn). Despite many investigations to characterize the binding of α-Syn to membranes, there is still a lack of understanding of the binding mode linking the properties of lipid membranes to α-Syn insertion into these dynamic structures. Using a combination of an optical biosensing technique and in situ atomic force microscopy, we show that the binding strength of α-Syn is related to the specificity of the lipid environment (the lipid chemistry and steric properties within a bilayer structure) and to the ability of the membranes to accommodate and remodel upon the interaction of α-Syn with lipid membranes. We show that this interaction results in the insertion of α-Syn into the region of the headgroups, inducing a lateral expansion of lipid molecules that can progress to further bilayer remodeling, such as membrane thinning and expansion of lipids out of the membrane plane. We provide new insights into the affinity of α-Syn for lipid packing defects found in vesicles of high curvature and in planar membranes with cone-shaped lipids and suggest a comprehensive model of the interaction between α-Syn and lipid bilayers. The ability of α-Syn to sense lipid packing defects and to remodel membrane structure supports its proposed role in vesicle trafficking.

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Mouritsen, Ole G., and Luis A. Bagatolli. "Lipid domains in model membranes: a brief historical perspective." Essays in Biochemistry 57 (February 6, 2015): 1–19. http://dx.doi.org/10.1042/bse0570001.

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All biological membranes consist of a complex composite of macromolecules and macromolecular assemblies, of which the fluid lipid-bilayer component is a core element with regard to cell encapsulation and barrier properties. The fluid lipid bilayer also supports the functional machinery of receptors, channels and pumps that are associated with the membrane. This bilayer is stabilized by weak physical and colloidal forces, and its nature is that of a self-assembled system of amphiphiles in water. Being only approximately 5 nm in thickness and still encapsulating a cell that is three orders of magnitude larger in diameter, the lipid bilayer as a material has very unusual physical properties, both in terms of structure and dynamics. Although the lipid bilayer is a fluid, it has a distinct and structured trans-bilayer profile, and in the plane of the bilayer the various molecular components, viz different lipid species and membrane proteins, have the capacity to organize laterally in terms of differentiated domains on different length and time scales. These elements of small-scale structure and order are crucial for the functioning of the membrane. It has turned out to be difficult to quantitatively study the small-scale structure of biological membranes. A major part of the insight into membrane micro- and nano-domains and the concepts used to describe them have hence come from studies of simple lipid bilayers as models of membranes, by use of a wide range of theoretical, experimental and simulational approaches. Many questions remain to be answered as to which extent the result from model studies can carry over to real biological membranes.

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Lee, Anthony G. "Integral membrane enzymes: What are the problems?" Biochemist 25, no. 4 (August 1, 2003): 17–19. http://dx.doi.org/10.1042/bio02504017.

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Integral membrane enzymes have to function in the environment provided by the lipid bilayer component of a membrane. This raises interesting problems of design; not only must these enzymes contain hydrophobic -helices or -barrels to span the lipid bilayer, they must also have a design compatible with the translocation machinery used to insert proteins into membranes. One solution is to separate functions in the enzyme as far as is possible, so that the enzymology is carried out in domains located outside the lipid bilayer. When active sites are located within the lipid bilayer, they are often located at protein-protein interfaces in dimeric structures. Because these enzymes are designed to operate in a lipid bilayer, they are best studied after reconstitution into lipid bilayers.

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Pasenkiewicz-Gierula, M., K. Murzyn, T. Róg, and C. Czaplewski. "Molecular dynamics simulation studies of lipid bilayer systems." Acta Biochimica Polonica 47, no. 3 (September 30, 2000): 601–11. http://dx.doi.org/10.18388/abp.2000_3982.

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The main structural element of biological membranes is a liquid-crystalline lipid bilayer. Other constituents, i.e. proteins, sterols and peptides, either intercalate into or loosely attach to the bilayer. We applied a molecular dynamics simulation method to study membrane systems at various levels of compositional complexity. The studies were started from simple lipid bilayers containing a single type phosphatidylcholine (PC) and water molecules (PC bilayers). As a next step, cholesterol (Chol) molecules were introduced to the PC bilayers (PC-Chol bilayers). These studies provided detailed information about the structure and dynamics of the membrane/water interface and the hydrocarbon chain region in bilayers built of various types of PCs and Chol. This enabled studies of membrane systems of higher complexity. They included the investigation of an integral membrane protein in its natural environment of a PC bilayer, and the antibacterial activity of magainin-2. The latter study required the construction of a model bacterial membrane which consisted of two types of phospholipids and counter ions. Whenever published experimental data were available, the results of the simulations were compared with them.

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Booth, Paula J., A. Rachael Curran, Richard H. Templer, Hui Lu, and Wim Meijberg. "Manipulating the folding of membrane proteins: using the bilayer to our advantage." Biochemical Society Symposia 68 (August 1, 2001): 27–33. http://dx.doi.org/10.1042/bss0680027.

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The folding mechanisms of integral membrane proteins have largely eluded detailed study. This is owing to the inherent difficulties in folding these hydrophobic proteins in vitro, which, in turn, reflects the often apparently insurmountable problem of mimicking the natural membrane bilayer with lipid or detergent mixtures. There is, however, a large body of information on lipid properties and, in particular, on phosphatidylcholine and phosphatidylethanolamine lipids, which are common to many biological membranes. We have exploited this knowledge to develop efficient in vitro lipid-bilayer folding systems for the membrane protein, bacteriorhodopsin. Furthermore, we have shown that a rate-limiting apoprotein folding step and the overall folding efficiency appear to be controlled by particular properties of the lipid bilayer. The properties of interest are the stored curvature elastic energy within the bilayer, and the lateral pressure that the lipid chains exert on the their neighbouring folding proteins. These are generic properties of the bilayer that can be achieved with simple mixtures of biological lipids, and are not specific to the lipids studied here. These bilayer properties also seem to be important in modulating the function of several membrane proteins, as well as the function of membranes in vivo. Thus, it seems likely that careful manipulations of lipid properties will shed light on the forces that drive membrane protein folding, and will aid the development of bilayer folding systems for other membrane proteins.

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Dissertations / Theses on the topic "Lipid bilayer membranes"

1

Veatch, Sarah Louise. "Liquid immiscibility in model bilayer lipid membranes /." Thesis, Connect to this title online; UW restricted, 2004. http://hdl.handle.net/1773/9772.

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Hartshorn, Christopher M. "Studies of the molecular effects of a solid support upon lipid membranes and membrane bound proteins." Pullman, Wash. : Washington State University, 2009. http://www.dissertations.wsu.edu/Dissertations/Fall2009/c_Hartshorn_101209.pdf.

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Wang, Chih-Ying. "Diffusion in hydrogel-supported lipid bilayer membranes." Thesis, McGill University, 2014. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=123227.

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Biomimetic membranes are powerful tools for fundamental studies of transmembrane proteins, and they can be used in sensing and separation technologies. This thesis presents theoretical models and experimental studies of diffusion in hydrogel-supported lipid bilayer membranes. Three hydrodynamic models are developed to assess tracer diffusion in (i) an hydrogel-supported single-leaflet membrane; (ii) a solid-supported dual-leaflet membrane; and (iii) an hydrogel-supported dual-leaflet membrane. The hydrogel-supported single-leaflet model describes transmembrane protein (tracer) diffusion in lipid bilayer membranes, and the hydrogel-supported dual-leaflet model generalizes this single-leaflet model, including inter-leaflet friction. The solid-supported dual-leaflet model allows tracers to span either one or both leaflets. The models quantify how the tracer diffusion is affected by hydrogel concentration, inter-leaflet friction, and a dimensionless parameter Λ. Thus, the models predict tracer diffusion coefficients based on key system parameters. In addition to theory, experiments were undertaken to measure lipid (PE-CF) and lipopolymer (DSPE-PEG2k-CF) self-diffusion coefficients in hydrogel-supported membranes, using fluorescence recovery after photo-bleaching (FRAP). The results show that polyacrylamide and agarose hydrogels can enhance tracer diffusion in DOPC bilayers, relative to their glass-supported counterparts. Moreover, the hydrogels impart size-exclusion and Brinkman screening effects, which may benefit membrane-based molecular-separation and sensing platforms.
Les membranes biomimétiques sont des outils puissants pour des études fondamentales sur des protéines transmembranaires, et pourraient être utilisées par les technologies de détection et de séparation. Cette thèse présente trois modèles théoriques et les études expérimentales de diffusion avec les membranes bicouches lipidiques soutenus par hydrogels. Trois modèles hydrodynamiques adresse la diffusion du traceur dans: (i) une membrane à feuillet unique soutenus par hydrogel, (ii) une membrane à double feuillet soutenus par solide, et (iii) une membrane à double feuillet soutenus par hydrogels. Le modèle à feuillet unique hydrogel soutenu décrit la diffusion de protéine transmembranaire (traceur) dans les membranes bicouches lipidiques, et le modèle à double feuillet hydrogel soutenu généralise ce modèle avec feuillet unique, dont la friction se prèsente inter-feuillet. Le modèle à double feuillet solide soutenu permet les traceurs de durée une ou deux feuillets bicouches lipidiques. Ces trois modèles wxpliquent comment la diffusion traceur est affectée par la concentration de l'hydrogel, et quantifiet les frottements entre feuillet, et un paramètre sans dimension Λ. Ces modèles peuvent ê tre utilisés pour prédire les coefficients de diffusion de traceurs grâce à des paramètres clés du système. Les expériences comprennent la diffusion des lipides (PE-CF) et diffusion lipopolymère (DSPE-PEG2k-CF) dans des bicouches lipidiques hydrogel soutenus, mesurée par la récupération de fluorescence après photoblanchiment. Les résultats expérimentaux montrent que le hydrogels polyacrylamide et agarose peuvent améliorer la diffusion de traceur dans des bicouches DOPC, par rapport à leurs homologues verre soutenus. Les hydrogels présentent également d'exclusion de taille et les effets de dépistage Brinkman. Les applications peuvent bénéficier des séparations moléculaires.

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Danial, John Shokri Hanna. "Imaging lipid phase separation on droplet interface bilayers." Thesis, University of Oxford, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.711943.

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LADHA, PARAG. "POLYMERIC MEMBRANE SUPPORTED BILAYER LIPID MEMBRANES RECONSTITUTED WITH BIOLOGICAL TRANSPORT PROTEINS." University of Cincinnati / OhioLINK, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1145901880.

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Daulton, Emma. "Biomimetic floating lipid membranes." Thesis, University of Bath, 2015. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.675722.

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Sears, Randy Bryan. "Permeability of POPC bilayer by dirhodium complexes." Columbus, Ohio : Ohio State University, 2008. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1194529853.

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Oldham, Alexis Jean. "Modulation of lipid domain formation in mixed model systems by proteins and peptides." View electronic thesis, 2008. http://dl.uncw.edu/etd/2008-1/r1/oldhama/alexisoldham.pdf.

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Zhang, Huaiying. "Lipopolymer diffusion and electrophoresis in supported lipid bilayer membranes." Thesis, McGill University, 2011. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=103712.

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Lipopolymer-containing phospholipid bilayers are important because of their potential as biological membrane models and biosensing platforms. This thesis presents systematic studies of lipopolymer self-diffusion, gradient diffusion, and electrophoresis in solid-supported lipid bilayers (SLBs). A reaction-diffusion fluorescence recovery after photobleaching (FRAP) model was developed to improve accuracy in furnishing the self-diffusion coefficient. Fourier transform post-electrophoresis relaxation (PER) was developed to ascertain the gradient diffusion coefficient, which had not been previously measured in two-dimensional membranes. Finally, a photobleaching technique was adopted to measure the electrophoretic mobility. Hindered self-diffusion and enhanced gradient diffusion with increasing lipopolymer concentration in SLBs were observed. The diffusion data at small but finite concentrations were successfully interpreted using existing theories for transmembrane protein diffusion with a soft lipopolymer interaction potential. Lipopolymer electrophoretic mobility qualitatively correlates with lipopolymer concentration in the same manner as the self-diffusion coefficient. However, the drag force during electrophoresis is larger than derived from the self-diffusion coefficient using the Stokes-Einstein relation. This is attributed to the oppositely directed electro-osmotic flow. A continuum model that calculates the hydrodynamic drag on the polymer chains according to a Brinkman model was developed to quantify lipopolymer electrophoresis. This model furnished excellent agreement with experiments, yielding the polymer segment Stokes radius, and a lipid-tail drag coefficient that increases slightly with lipopolymer concentration.
Les bicouches de phospholipides contenant des lipopolymères sont importantes en raison de leur potentiel en tant que substituts de membranes biologiques et plate-formes de bio-détection. Cette thèse présente l'étude systématique de l'auto-diffusion, de la diffusion sous gradient et de l'électrophorèse des lipopolymères au travers de bicouches lipidiques soutenues au moyen de supports solides (SLBs). Un model de récupération de fluorescence sous forme de réaction-diffusion après photo-blanchiment (FRAP) a été développé afin d'améliorer la précision des résultats fournissant les coefficients d'autodiffusion. La transformée de Fourier de relaxation post-électrophorèse (PER) a été calculée afin de confirmer la valeur du coefficient de diffusion sous gradient qui n'avait pas encore été mesurée pour le cas de membranes bidimensionnelles. Enfin, une technique de photo-blanchiment a été adoptée en vue de mesurer la mobilité électrophorétique. Les résultats ont montré d'une part qu'une augmentation de la concentration en lipopolymères SLBs avait pour effets contraires de faciliter la diffusion sous gradient mais de contrarier l'auto-diffusion. D'autre part, les données relatives à la diffusion dans le cas de concentrations faibles mais mesurables ont pu être interprétées à l'aide de théories déjà existantes sur la diffusion de protéines transmembranaires ayant un potentiel d'interaction peu élevé avec les lipopolymères. La mobilité électrophorétique des lipopolymères est en corrélation avec leur concentration d'un point de vue qualitatif, de même que l'est le coefficient d'auto-diffusion. Toutefois, la force de traînée expérimentale obtenue pour l'électrophorèse est plus importante que la force théorique calculée par implémentation du coefficient d'auto-diffusion dans la relation de Stokes-Einstein. Cette hausse est attribuée à l'écoulement du flux électro-osmotique en sens inverse. Un modèle en continuum calculant la traînée hydrodynamique sur les chaînes polymériques à partir d'un modèle de Brinkman a été développé afin de quantifier l'électrophorèse des lipopolymères. Ce modèle a fourni des résultats en excellent accord avec les expériences, entre autres concernant le rayon de Stokes de segments polymériques et le coefficient de traînée de la terminaison lipidique qui augmente légèrement avec la concentration en lipopolymères.

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Zhu, Hong 1975. "Numerical studies of diffusion in lipid-sterol bilayer membranes." Thesis, McGill University, 2000. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=30776.

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We examine tracer diffusion in lipid bilayer membranes containing either cholesterol or lanosterol, using a random lattice Ising model. Specifically the model is a two-state off lattice tethered network of hard disks which is dynamically triangulated and the interactions between the hard disks are only effective along the tethers linking the disks. The model was already applied to lipid-sterol systems and was successful in reproducing the phase diagrams and related physical properties. In this thesis we apply this model in conjunction with Monte Carlo simulation methods as follows. We calculate the diffusion constant for lipid-cholesterol and lipid-lanosterol bilayer membranes both as function of temperature and sterol concentration in all accessible regions of the relevant phase diagrams. Comparison with experiment and comments on sterol related evolution are included.

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Books on the topic "Lipid bilayer membranes"

1

Hanke, W. Planar lipid bilayers: Methods and applications. London: Academic Press, 1993.

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Hianik, Tibor. Bilayer lipid membranes: Structure and mechanical properties. Dordrecht: Kluwer Academic Publishers, 1995.

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Ottova-Leitmannova, Angelica, and H. Ti Tien. Advances in planar lipid bilayers and liposomes. Edited by Iglic Ales. Amsterdam: Elsevier/Academic Press, 2005.

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I͡U︡, Smirnova E., and Shevchenko E. V, eds. Lipidnye membrany pri fazovykh prevrashchenii͡a︡kh. Moskva: "Nauka", 1992.

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Paul, Gaber Bruce, Schnur Joel M, Chapman Dennis 1927-, and Workshop on Biotechnological Applications of Membranes Studies (1987 : San Sebastian, Spain), eds. Biotechnological applications of lipid microstructures. New York: Plenum Press, 1988.

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service), ScienceDirect (Online, ed. Computational modeling of membrane bilayers. London: Academic Press, 2008.

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Passechnik, Viktor I. Transversal elasticity of lipid membranes. Bratislava: Veda, 1991.

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Marsh, Derek. CRC handbook of lipid bilayers. Boca Raton, Fla: CRC Press, 1990.

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Electrochemical Society Symposium on Electrical Double Layers in Biology (1985 Toronto, Ont.). Electrical double layers in biology. New York: Plenum Press, 1986.

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Finkelstein, Alan. Water movement through lipid bilayers, pores, and plasma membranes: Theory and reality. New York: Wiley, 1987.

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Book chapters on the topic "Lipid bilayer membranes"

1

Chizmadzhev, Yuri A., Justin Teissié, and Dieter Walz. "Lipid Bilayer Electropermeabilization." In Bioelectrochemistry of Membranes, 173–203. Basel: Birkhäuser Basel, 2004. http://dx.doi.org/10.1007/978-3-0348-7853-1_5.

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Knoll, Wolfgang, Kenichi Morigaki, Renate Naumann, Barbara Saccà, Stefan Schiller, and Eva-Kathrin Sinner. "Functional Tethered Bilayer Lipid Membranes." In Ultrathin Electrochemical Chemo- and Biosensors, 239–53. Berlin, Heidelberg: Springer Berlin Heidelberg, 2004. http://dx.doi.org/10.1007/978-3-662-05204-4_10.

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Powers, Thomas R. "Mechanics of Lipid Bilayer Membranes." In Handbook of Materials Modeling, 2631–43. Dordrecht: Springer Netherlands, 2005. http://dx.doi.org/10.1007/978-1-4020-3286-8_141.

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Mishima, Kiyoshi. "Birefringence in Lipid Bilayer Membranes." In Encyclopedia of Biocolloid and Biointerface Science 2V Set, 661–73. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2016. http://dx.doi.org/10.1002/9781119075691.ch54.

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Powers, Thomas R. "Mechanics of Lipid Bilayer Membranes." In Handbook of Materials Modeling, 2631–43. Dordrecht: Springer Netherlands, 2005. http://dx.doi.org/10.1007/1-4020-3286-2_141.

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Silver, Brian L. "Theory and the Lipid Bilayer." In The Physical Chemistry of MEMBRANES, 189–208. Dordrecht: Springer Netherlands, 1985. http://dx.doi.org/10.1007/978-94-010-9628-7_8.

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Silver, Brian L. "Proteins, Cholesterol, and the Lipid Bilayer." In The Physical Chemistry of MEMBRANES, 209–30. Dordrecht: Springer Netherlands, 1985. http://dx.doi.org/10.1007/978-94-010-9628-7_9.

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Needham, David. "Micropipette Manipulation of Lipid Bilayer Membranes." In Encyclopedia of Biophysics, 1524–38. Berlin, Heidelberg: Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-16712-6_562.

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Chernomordik, Leonid V., and Yuri A. Chizmadzhev. "Electrical Breakdown of Lipid Bilayer Membranes." In Electroporation and Electrofusion in Cell Biology, 83–95. Boston, MA: Springer US, 1989. http://dx.doi.org/10.1007/978-1-4899-2528-2_5.

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Chizmadzhev, Yury. "Structural Rearrangements in Lipid Bilayer Membranes." In Electrified Interfaces in Physics, Chemistry and Biology, 491–507. Dordrecht: Springer Netherlands, 1992. http://dx.doi.org/10.1007/978-94-011-2566-6_20.

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Conference papers on the topic "Lipid bilayer membranes"

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Taylor, Graham, Donald Leo, and Andy Sarles. "Detection of Botulinum Neurotoxin/A Insertion Using an Encapsulated Interface Bilayer." In ASME 2012 Conference on Smart Materials, Adaptive Structures and Intelligent Systems. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/smasis2012-8101.

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Many signaling mechanisms in living cells occur at biological boundaries via cell surface receptors and membrane proteins embedded in lipid bilayers. The coordination of actions of sensory and motor neurons in the nervous system represents one example of many that heavily depends on lipid membrane bound receptor mediated signaling. As a result, chemical and biological toxins that disrupt these neural signals can have severe physiological effects, including paralysis and death. Botulinum neurotoxin Type A (BoNT/A) is a proteolytic toxin that inserts through vesicle membranes and cleaves membrane receptors involved with synaptic acetylcholine uptake and nervous system signal conduction. In this work, we investigate the use of a Bioinspired liquid-supported interface bilayer for studying the insertion of BoNT/A toxin molecules into synthetic lipid bilayers. DPhPC lipid bilayers are formed using the regulated attachment method (RAM), as developed by Sarles and Leo, and we perform current measurements on membranes exposed to BoNT/A toxin to characterize activity of toxin interacting with the synthetic bilayer. Control tests without toxin present are also presented. The results of these tests show an increase in the magnitude of current through the bilayer when the toxin is included. We interpret these initial results to mean that incorporation of BoNT/A toxin at a high concentration in an interface bilayer increases the permeability of the membrane as a result of toxin molecules spanning the thickness of the bilayer.

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Shao, C., and D. L. DeVoe. "Microfluidic Emulsion Generation and Trapping Enabling Droplet-Interfaced Bilayer Lipid Membrane Arrays." In ASME 2009 International Mechanical Engineering Congress and Exposition. ASMEDC, 2009. http://dx.doi.org/10.1115/imece2009-11410.

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Freestanding bilayer lipid membranes provide an exceptional platform for measurements of lipid/protein interactions and ion translocation events at the single molecule level. For drug screening applications, large arrays of individual bilayer supports are required. However, an effective method for generating, stabilizing, and monitoring arrays of lipid bilayers remains elusive. Here we investigate a novel approach towards the facile generation of bilayer arrays for high throughput screening. The approach takes advantage of fundamental microfluidic capabilities by combining an emulsion generator with droplet-interfaced membrane formation, allowing for fully-automated production of membrane arrays whose density is, in principle, unlimited.

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Hopkinson, David, Raffaella De Vita, and Donald J. Leo. "Failure pressure of bilayer lipid membranes." In Smart Structures and Materials, edited by William D. Armstrong. SPIE, 2006. http://dx.doi.org/10.1117/12.657963.

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Ottova, Angelica L., Ding-li Guo, and H. Ti Tien. "Electrochemical sensors using supported bilayer lipid membranes." In 1994 North American Conference on Smart Structures and Materials, edited by Vijay K. Varadan. SPIE, 1994. http://dx.doi.org/10.1117/12.174081.

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Zhang, Hao, Vishnu Baba Sundaresan, Sergio Salinas, and Robert Northcutt. "Electrochemical Analysis of Alamethicin Reconstituted Planar Bilayer Lipid Membranes Supported on Polypyrrole Membranes." In ASME 2011 Conference on Smart Materials, Adaptive Structures and Intelligent Systems. ASMEDC, 2011. http://dx.doi.org/10.1115/smasis2011-5038.

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Conducting polymers possess similarity in ion transport function to cell membranes and perform electro-chemo-mechanical energy conversion. In an in vitro setup, protein-reconstituted bilayer lipid membranes (bioderived membranes)perform similar energy conversion and behave like cell membranes. Inspired by the similarity in ionic function between a conducting polymer membrane and cell membrane, this article presents a thin-film laminated membrane in which alamethicin-reconstituted lipid bilayer membrane is supported on a polypyrrole membrane. Owing to the synthetic and bioderived nature of the components of the membrane, we refer to the laminated membrane as a hybrid bioderived membrane. In this article, we describe the fabrication steps and electrochemical characterization of the hybrid membrane. The fabrication steps include electropolymerization of pyrrole and vesicle fusion to result in a hybrid membrane; and the characterization involves electrical impedance spectroscopy, chronoamperometry and cyclic voltammetry. The resistance and capacitance of BLM have the magnitude of 4.6×109Ω-cm2 and 1.6×10−8 F/cm2.The conductance of alamethicin has the magnitude of 6.4×10−8 S/cm2. The change in ionic conductance of the bioderived membrane is due to the electrical field applied across alamethicin, a voltage-gated protein and produces a measurable change in the ionic concentration of the conducting polymer substrate.

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Nussio, Matthew, Matthew Sykes, John Miners, and Joseph Shapter. "Characterisation of chlorpromazine binding to lipid bilayer membranes." In 2006 International Conference on Nanoscience and Nanotechnology. IEEE, 2006. http://dx.doi.org/10.1109/iconn.2006.340603.

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Lykotrafitis, George, and He Li. "Two-Component Coarse-Grain Model for Erythrocyte Membrane." In ASME 2011 International Mechanical Engineering Congress and Exposition. ASMEDC, 2011. http://dx.doi.org/10.1115/imece2011-62133.

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Biological membranes are vital components of living cells as they function to maintain the structural integrity of the cells. Red blood cell (RBC) membrane comprises the lipid bilayer and the cytoskeleton network. The lipid bilayer consists of phospholipids, integral membrane proteins, peripheral proteins and cholesterol. It behaves as a 2D fluid. The cytoskeleton is a network of spectrin tetramers linked at the actin junctions. It is connected to the lipid bilayer primarily via Band-3 and ankyrin proteins. In this paper, we introduce a coarse-grained model with high computational efficiency for simulating a variety of dynamic and topological problems involving erythrocyte membranes. Coarse-grained agents are used to represent a cluster of lipid molecules and proteins with a diameter on the order of lipid bilayer thickness and carry both translational and rotational freedom. The membrane cytoskeleton is modeled as a canonical exagonal network of entropic springs that behave as Worm-Like-Chains (WLC). By simultaneously invoking these characteristics, the proposed model facilitates simulations that span large length-scales (∼ μm) and time-scales (∼ ms). The behavior of the model under shearing at different rates is studied. At low strain rates, the resulted shear stress is mainly due to the spectrin network and it shows the characteristic non-linear behavior of entropic networks, while the viscosity of the fluid-like lipid bilayer contributes to the resulting shear stress at higher strain rates. The apparent ease of this model in combining the spectrin network with the lipid bilayer presents a major advantage over conventional continuum methods such as finite element or finite difference methods for cell membranes.

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Nakano, Takeo, Gota Kikugawa, and Taku Ohara. "Effect of Alkyl Chain Length on Molecular Heat Transfer Characteristics in Lipid Bilayers." In ASME/JSME 2011 8th Thermal Engineering Joint Conference. ASMEDC, 2011. http://dx.doi.org/10.1115/ajtec2011-44465.

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Nonequilibrium molecular dynamics simulations are carried out on single component lipid bilayers with ambient water in order to investigate the effect of acyl chain length on heat transport characteristics along and across the membranes. In this study, dipalmitoyl-phosphatidyl-choline (DPPC), dilauroyl-phosphatidyl-choline (DLPC), and stearoyl-myristoyl-phosphatidyl-choline (SMPC) which has two acyl chains of both sixteen C atoms, both twelve C atoms, and eighteen and fourteen C atoms, respectively, were used as lipid molecules. In the direction along the membranes, thermal conductivity corresponds with that of each membrane. On the other hand, in the direction across membrane, the highest thermal resistance exists at the center of lipid bilayer where lipid acyl chains face each other. However, asymmetric chain length reduces thermal resistance at the interface between lipid monolayers. Therefore, thermal conductivity across the membrane which consists of asymmetric chain length is higher than those which consist of symmetric chain length.

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Nguyen, Mary-Anne, and Stephen A. Sarles. "Microfluidic Generation, Encapsulation and Characterization of Asymmetric Droplet Interface Bilayers." In ASME 2016 Conference on Smart Materials, Adaptive Structures and Intelligent Systems. American Society of Mechanical Engineers, 2016. http://dx.doi.org/10.1115/smasis2016-9034.

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Our research focuses on creating smart materials that utilize synthetic cell membranes assembled at liquid interfaces for autonomic sensing, actuation, and energy conversion. Unlike single membrane assemblies, systems featuring many membranes have the potential to offer multi-functionality, greater transduction sensitivity, and even emergent behaviors in response to environmental stimuli, similar to living tissue, which utilizes networks of highly packed cells to accomplish tasks. Here, we present for the first time a novel microfluidic platform capable of generating a stream of alternating droplet compositions, i.e. A-B-A-B, and sequentially capturing these droplets in precise locations to enable the spontaneous formation of synthetic lipid bilayers between droplets of different compositions (i.e. A and B) in an enclosed substrate. This platform preserves a key feature of the droplet interface bilayer (DIB) method, which allows asymmetric conditions within and across the membrane to be prescribed by simply using droplets containing different species. In this work, we demonstrate the ability to assemble bilayers consisting of asymmetric lipid compositions and, separately, show that alternating droplets containing the same lipid type can also be used to control the direction of ion channel insertion. In the first study, A and B droplet types contain liposomes comprised of different lipid types, which are used to establish an asymmetric composition of the leaflets that make up the lipid bilayer. This asymmetry results in a dc, non-zero membrane potential, which we measure via membrane capacitance versus bias voltage. In the second study, alamethicin peptides are included in only one of the droplet types, which enable voltage-dependent insertion to occur only at one polarity. Cyclic voltammetry measurements are performed to confirm the direction of insertion of alamethicin channels in bilayers. Also, these results show the ability to perform simultaneously electrical measurements on multiple DIB, which increases the experimental capacity and efficiency of a microfluidic approach. The ability to produce alternating droplets in a high throughput manner with electrical access provides a system to investigate the effects of lipid asymmetry on the function of membrane proteins in a controlled model system.

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Creasy, M. Austin, and Donald J. Leo. "Self-Healing Bilayer Lipid Membranes Formed Over Synthetic Substrates." In ASME 2008 Conference on Smart Materials, Adaptive Structures and Intelligent Systems. ASMEDC, 2008. http://dx.doi.org/10.1115/smasis2008-460.

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Biological systems demonstrate autonomous healing of damage and are an inspiration for developing self-healing materials. Our recent experimental study has demonstrated that a bilayer lipid membrane (BLM), also called a black lipid membrane, has the ability to self-heal after mechanical failure. These molecules have a unique property that they spontaneously self assembly into organized structures in an aqueous medium. The BLM forms an impervious barrier to ions and fluid between two volumes and strength of the barrier is dependent on the pressure and electrical field applied to the membrane. A BLM formed over an aperture on a silicon substrate is shown to self-heal for 5 pressurization failure cycles.

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Reports on the topic "Lipid bilayer membranes"

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Hermes, Uwe. Impedance spectroscopy of bilayer lipid membranes and TiO₂ based solar cells. Portland State University Library, January 2000. http://dx.doi.org/10.15760/etd.7275.

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Sinha, Barbara. Physical effects of 3-phenylindole on ion transport across bilayer lipid membranes. Portland State University Library, January 2000. http://dx.doi.org/10.15760/etd.474.

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Perman, William. The effects of pentachlorophenol on the electrical conductivity of lipid bilayer membranes. Portland State University Library, January 2000. http://dx.doi.org/10.15760/etd.2061.

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Cohen, Scott. The application of exact electrodiffusion theory to ion transport across lipid bilayer membranes. Portland State University Library, January 2000. http://dx.doi.org/10.15760/etd.3237.

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Illangasekare, Malkanthi. Effect of phenoxy acids and their derivatives on the ionic permeability of bilayer lipid membranes. Portland State University Library, January 2000. http://dx.doi.org/10.15760/etd.850.

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Cox, Kenneth. Alternating current studies and kinetic analysis of valinomycin mediated charge-transport through lipid bilayer membranes. Portland State University Library, January 2000. http://dx.doi.org/10.15760/etd.5253.

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Fendler, J. Bilayer lipid membrane-supported electronic devices. Office of Scientific and Technical Information (OSTI), January 1989. http://dx.doi.org/10.2172/5367733.

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