Relevant bibliographies by topics / Lipid formulation

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'Lipid formulation'

Author: Grafiati
Published: 4 June 2021
Last updated: 1 February 2022

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Journal articles on the topic "Lipid formulation"

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Boyd, Ben J., and Andrew J. Clulow. "The influence of lipid digestion on the fate of orally administered drug delivery vehicles." Biochemical Society Transactions 49, no. 4 (2021): 1749–61. http://dx.doi.org/10.1042/bst20210168.

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This review will focus on orally administered lipid-based drug delivery vehicles and specifically the influence of lipid digestion on the structure of the carrier lipids and their entrained drug cargoes. Digestion of the formulation lipids, which are typically apolar triglycerides, generates amphiphilic monoglycerides and fatty acids that can self-assemble into a diverse array of liquid crystalline structures. Tracking the dynamic changes in self-assembly of the lipid digestion products during digestion has recently been made possible using synchrotron-based small angle X-ray scattering. The influence of lipid chain length and degree of unsaturation on the resulting lipid structuring will be described in the context of the critical packing parameter theory. The chemical and structural transformation of the formulation lipids can also have a dramatic impact on the physical state of drugs co-administered with the formulation. It is often assumed that the best strategy for drug development is to maximise drug solubility in the undigested formulation lipids and to incorporate additives to maintain drug solubility during digestion. However, it is possible to improve drug absorption using lipid digestion in cases where the solubility of the dosed drug or one of its polymorphic forms is greater in the digested lipids. Three different fates for drugs administered with digestible lipid-based formulations will be discussed: (1) where the drug is more soluble in the undigested formulation lipids; (2) where the drug undergoes a polymorphic transformation during lipid digestion; and (3) where the drug is more soluble in the digested formulation lipids.
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Peddappi Reddigari, Jayachandra Reddy, Yerikala Ramesh, and Chandrasekhar B. Kothapalli. "Formulation and evaluation of in-situ gels enriched with Tropicamide loaded solid lipid nanoparticles." International Journal of Research in Pharmaceutical Sciences 9, no. 1 (2018): 216. http://dx.doi.org/10.26452/ijrps.v9i1.1250.

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The present research work “Formulation and Evaluation of In-situ gels enriched with Tropicamide loaded solid lipid nanoparticles”. To overcome the problems of side effects and to increase the bioavailability of tropicamide loaded solid lipid nanoparticles are containing with suitable lipids (glycerin trimyristate, Tristearin, Phosphatidylcholine & soyabean lecithin) with stabilizers (poloxamer 188) and surfactant like polysorbate 80. The interaction between drug, lipids & polymer by performing with FTIR no incompatibility with each other. The particle morphology was carried out by SEM & AFM in solid lipid nanoparticle formulation. The particle size was ranges from 213.6 ± 2.16nm to 538.0 ± 6.53 nm. The zeta potential ranges form -18.3mV to 25.6mV. The entrapment efficiency of free tropicamide was ranges from 74.13 % to 90.17%. The drug content was ranges from 0.212mg/ml to 0.912mg/ml. The SLN formulations must be transparent white colour and semi solid consistency. The pH 7.0 to 8.0 in all formulation. The gelling strength of gels TSLNGF1 to TSLNGF12 was ranges from 72 ± 1 sec to 117 ± 2 sec. The bio adhesive force was ranges from 10.12 ±1.01 dynes/cm2 to 23.12 ± 1.91 dynes/cm2. The viscosity of prepared formulation ranges from 415 ± 1.94 cps to 652 ± 1.41 cps. The spread ability studies of all formulation were ranges from 09 gms/sec to 18 gms/sec. The Accelerated stability the formulations does not undergo any chemical Changes. In vitro Franz’s diffusion studies of SLN enriched in gels TSLNGF1 to TSLNGF12 among the various formulation best formulations was TSLNGF6; its follows first order kinetics.
 Keywords: Solid Lipid Nanoparticles; Tropicamide; In- situ gels; In vitro diffusion studies
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Dutta, Sandeep, and William F. Ebling. "Formulation-dependent Brain and Lung Distribution Kinetics of Propofol in Rats." Anesthesiology 89, no. 3 (1998): 678–85. http://dx.doi.org/10.1097/00000542-199809000-00018.

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Background Propofol when administered by brief infusion in a lipid-free formulation has a slower onset, prolonged offset and greater potency compared with an emulsion formulation. To understand these findings the authors examined propofol brain and lung distribution kinetics in rats. Methods Rats were infused with equieffective doses of propofol in emulsion (n = 21) or lipid-free formulation (n = 21). Animals were sacrificed at various times to harvest brain and lung. Arterial blood was sampled repeatedly from each animal until sacrifice. Deconvolution and moment analysis were used to calculate the half-life for propofol brain turnover (BT) and brain:plasma partition coefficient (Kp). Lung concentration-time profiles were compared for the two formulations. Results Peak propofol plasma concentrations for the lipid-free formulation were 50% of that observed for emulsion formulation, whereas peak lung concentrations for lipid-free formulation were 300-fold higher than emulsion formulation. Brain Kp calculated from tissue disposition curve and ratio of brain:plasma area under the curves were 8.8 and 13, and 7.2 and 9.1 for emulsion and lipid-free formulations, respectively. BT were 2.4 and 2.5 min for emulsion and lipid-free formulations, respectively. Conclusions Significant pulmonary sequestration and slow release of propofol into arterial circulation when administered in lipid-free vehicle accounts for the lower peak arterial concentration and sluggish arterial kinetics relative to that observed with the emulsion formulation. Higher Kp for the lipid-free formulation could explain the higher potency associated with this formulation. BT were independent of formulation and correlated with values reported for effect-site equilibration half-time consistent with a distribution mechanism for pharmacologic hysteresis.
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Chime, Salome A., Paul A. Akpa, and Anthony A. Attama. "The Utility of Lipids as Nanocarriers and Suitable Vehicle in Pharmaceutical Drug Delivery." Current Nanomaterials 4, no. 3 (2019): 160–75. http://dx.doi.org/10.2174/2405461504666191016091827.

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Lipid based excipients have gained popularity recently in the formulation of drugs in order to improve their pharmacokinetic profiles. For drugs belonging to the Biopharmaceutics Classification System (BCS) class II and IV, lipid excipients play vital roles in improving their pharmacokinetics properties. Various nanocarriers viz: Solid lipid nanoparticles, nanostructured lipid carriers, selfnanoemulsifying drug delivery systems (SNEDDS), nanoliposomes and liquid crystal nanoparticles have been employed as delivery systems for such drugs with evident successes. Lipid-based nanotechnology have been used to control the release of drugs and have utility for drug targeting and hence, have been used for the delivery of various anticancer drugs and for colon targeting. Drugs encapsulated in lipids have enhanced stability due to the protection they enjoy in the lipid core of these nanoformulations. However, lipid excipients could be influenced by factors which could affect the physicochemical properties of lipid-based drug delivery systems (LBDDS). These factors include the liquid crystalline phase transition, lipid crystallization and polymorphism amongst others. However, some of the physicochemical properties of lipids made them useful as nanocarriers in the formulation of various nanoformulations. Lipids form vesicles of bilayer which have been used to deliver drugs and are often referred to as liposomes and nanoliposomes. This work aims at reviewing the different classes of lipid excipients used in formulating LBDDS and nanoformulations. Also, some factors that influence the properties of lipids, different polymorphic forms in lipid excipients that made them effective nanocarriers in nano-drug delivery would be discussed. Special considerations in selecting lipid excipients used in formulating various forms of nanoformulations would be discussed.
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Singh, Sukhwinder, Sukhmeet Singh Kamal, Amit Sharma, Daljit Kaur, Manoj Kumar Katual, and Rajesh Kumar. "Formulation and In-Vitro Evaluation of Solid Lipid Nanoparticles Containing Levosulpiride." Open Nanomedicine Journal 4, no. 1 (2017): 17–29. http://dx.doi.org/10.2174/1875933501704010017.

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Objectives: The present study aims on preparing Levosulpiride loaded solid lipid nanoparticles (SLNs) to reduce the dose, frequency of dosing, reduce side effects and to increase the bioavailable fraction of drug (<30% orally in general). Methods: Levosulpiride was characterized by preformulation studies like physical appearance, melting point, assay, calibration curve, FTIR analysis and DSC analysis. The calibration curve of the drug was prepared in pH 6.8 phosphate buffer. Two lipids (Stearic acid and Palmitic acid) were used as lipid phase to prepare SLNs. Factorial design (23) was applied to formulate 16 formulations (8 for each lipid i.e. SF1-SF8 and PF1-PF8). Levosulpiride SLNs were prepared by solvent evaporation method followed by homogenization. Results: The optimized formulations were characterized by particle size analysis, zeta potential analysis, in vitro drug release and drug release kinetics. Drug-excipient interaction in optimized formulation was characterized by FTIR, DSC and TEM analysis. Conclusion: On the basis of evaluation parameters, the formulation SF1 (containing Stearic acid) and PF1 (containing Palimitic acid) found to be better formulations amongst their groups with a controlled drug release after a period of 24 hrs.
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Dobreva, Mirena, Stefan Stefanov, and Velichka Andonova. "Natural Lipids as Structural Components of Solid Lipid Nanoparticles and Nanostructured Lipid Carriers for Topical Delivery." Current Pharmaceutical Design 26, no. 36 (2020): 4524–35. http://dx.doi.org/10.2174/1381612826666200514221649.

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Background: Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) are useful drug delivery systems for dermal application. Thanks to their biocompatible and biodegradable profile, these carriers offer many advantages such as enhanced bioavailability, low toxicity, viable drug targeting and controlled release. SLN and NLC are composed of well-tolerated lipids, including natural fats and oils that are successfully used in the pharmaceutical and cosmetic dermal formulation. Objective: This article presents an overview of the benefits of selecting natural fats and oils as structural components of SLN and NLC for topical application. Methods: This review is based on data published over the past 20 years about the development of stable and nontoxic lipid nanoparticles with natural lipids. We shed light on the role of natural fats in skin restoration, as well as on the contributed penetration and occlusive properties of SLN and NLC. Results: The deliberate selection of excipients (type and lipid ratio) influences the quality of the final dermal formulation. Natural lipids show good compatibility with different active molecules and are able to create stable lipid matrices that facilitate the biopharmaceutical properties of lipid nanoparticles. Patents involving natural fats and oils in SLN and NLC composition are listed, yet it is important to note that the approved marketed formulations are mainly cosmetic, not pharmaceutical, products. Conclusion: Natural lipids can enhance topical drug delivery by adding their ability of improving skin penetration and hydration to the permeation and occlusion properties of SLN and NLC.
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Shrestha, Hina, Rajni Bala, and Sandeep Arora. "Lipid-Based Drug Delivery Systems." Journal of Pharmaceutics 2014 (May 19, 2014): 1–10. http://dx.doi.org/10.1155/2014/801820.

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The principle objective of formulation of lipid-based drugs is to enhance their bioavailability. The use of lipids in drug delivery is no more a new trend now but is still the promising concept. Lipid-based drug delivery systems (LBDDS) are one of the emerging technologies designed to address challenges like the solubility and bioavailability of poorly water-soluble drugs. Lipid-based formulations can be tailored to meet a wide range of product requirements dictated by disease indication, route of administration, cost consideration, product stability, toxicity, and efficacy. These formulations are also a commercially viable strategy to formulate pharmaceuticals, for topical, oral, pulmonary, or parenteral delivery. In addition, lipid-based formulations have been shown to reduce the toxicity of various drugs by changing the biodistribution of the drug away from sensitive organs. However, the number of applications for lipid-based formulations has expanded as the nature and type of active drugs under investigation have become more varied. This paper mainly focuses on novel lipid-based formulations, namely, emulsions, vesicular systems, and lipid particulate systems and their subcategories as well as on their prominent applications in pharmaceutical drug delivery.
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P, Ashok Kumar, Mancy S.P., Manjunath K, Suresh V. Kulkarni, and Jagadeesh R. "Formulation and Evaluation of Fluvoxamine Maleate Loaded Lipid Nanoparticle." International Journal of Pharmaceutical Sciences and Nanotechnology 12, no. 4 (2019): 4593–600. http://dx.doi.org/10.37285/ijpsn.2019.12.4.5.

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Recently solid lipid nanoparticles (SLN's) have been received much attention by the researchers owing to its biodegradability, bioavailability and the ability to deliver wide range of drugs to the targeted site of action. The purpose of the present study is to develop and evaluate the fluvoxamine maleate loaded lipid nanoparticles. The fluvoxamine maleate lipid nanoparticles (LN’s) were prepared by the hot melt homogenization followed by the sonication by using different combination of lipids like tristearin, compritol, olive oil, coconut oil, sesame oil. Compatibility study was confirmed by FTIR and DSC. The LN’s were evaluated for particle size, PDI, zeta potential, entrapment efficiency and in-vitro drug release. For the Fluvoxamine maleate LN’s prepared using the solid lipids, the particle size ranged from 98.58 to 152.43 nm. PDI of all formulations were good within the range of 0.239 to 0.456 with zeta potential from - 6.52 to -18.6 mV. Entrapment efficiency observed was in the range of 64.56 to 84.23 %. The cumulative percentage release of fluvoxamine maleate from different LN’s varied from 46.14 to 81.48%. For the formulations prepared using the combination of solid lipids and liquid lipids, Fluvoxamine maleate LN’s the particle size ranged from 63.22 to 263.8 nm. With good PDI range from 0.229 to 0.514 Zeta potential of all formulation is from - 5.01 to -9.30 mV. Entrapment efficiency observed was in the range of 71.02 to 90.51 %. The cumulative percentage release of fluvoxamine maleate from different LN’s varied from 63.71 to 85.41% depending upon the drug lipid ratio, the type of lipid used. The release kinetic studies showed that the release was first order, diffusion controlled, and the ‘n’ values obtained from the Korsmeyer-Peppa’s model indicated the release mechanism was Anomalous (non-Fickian) diffusion type.
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Chauhan, Iti, Mohd Yasir, Madhu Verma, and Alok Pratap Singh. "Nanostructured Lipid Carriers: A Groundbreaking Approach for Transdermal Drug Delivery." Advanced Pharmaceutical Bulletin 10, no. 2 (2020): 150–65. http://dx.doi.org/10.34172/apb.2020.021.

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Nanostructured lipid carriers (NLCs) are novel pharmaceutical formulations which are composed of physiological and biocompatible lipids, surfactants and co-surfactants. Over time, as a second generation lipid nanocarrier NLC has emerged as an alternative to first generation nanoparticles. This review article highlights the structure, composition, various formulation methodologies, and characterization of NLCs which are prerequisites in formulating a stable drug delivery system. NLCs hold an eminent potential in pharmaceuticals and cosmetics market because of extensive beneficial effects like skin hydration, occlusion, enhanced bioavailability, and skin targeting. This article aims to evoke an interest in the current state of art NLC by discussing their promising assistance in topical drug delivery system. The key attributes of NLC that make them a promising drug delivery system are ease of preparation, biocompatibility, the feasibility of scale up, non-toxicity, improved drug loading, and stability.
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Kim, Min-Hwan, Yae-Eun Jeon, Soobeen Kang, et al. "Lipid Nanoparticles for Enhancing the Physicochemical Stability and Topical Skin Delivery of Orobol." Pharmaceutics 12, no. 9 (2020): 845. http://dx.doi.org/10.3390/pharmaceutics12090845.

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Orobol is one of the major soy isoflavones, and has been reported to have various pharmacological activities, including an anti-skin-aging effect. However, since it has low solubility in water and physicochemical instability, the formulation of orobol for delivery into the dermal layer of the skin could be challenging. The objective of this study was to prepare lipid nanoparticles formulations of orobol to enhance its stability as well as its deposition into the skin. Formulations of orobol-loaded solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) were characterized in terms of their mean particle size, entrapment efficiency, and morphology. The nano-sized spherical NLCs formulations maintained the stability of orobol for up to 28 days. Moreover, the NLCs formulation significantly increased the in vitro deposition of orobol into both Strat-M membranes and human cadaver skin compared with the other formulations. Additionally, the NLCs formulation did not cause significant skin irritation in clinical study. These results demonstrate that a shea butter-based NLC formulation could be a promising and safe carrier system for improving the stability of orobol and enhancing its topical skin delivery.
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Dissertations / Theses on the topic "Lipid formulation"

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Lau, Kent G. "Formulation of novel double-chain lipid vesicles." Thesis, University College London (University of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.272376.

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Ranchhod, Janeeta. "Formulation, development and evaluation of lipid nanocarriers for minocycline hydrochloride." Thesis, Rhodes University, 2017. http://hdl.handle.net/10962/65234.

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Thong, Li Ming. "Effect of formulation variables on insulin localisation within solid lipid nanoparticles." Thesis, University of Nottingham, 2016. http://eprints.nottingham.ac.uk/31206/.

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There has been a lot of interest on solid lipid nanoparticles (SLNs) as these colloidal submicron drug dosage forms present a promising frontier in drug delivery. It is possible to incorporate susceptible drugs such as protein intended for oral delivery. Here, we aim to develop an oral delivery system based on SLNs to deliver the peptide hormone, insulin using the double emulsion (W/O/W) solvent evaporation technique for formulating the SLNs. The choice of lipids was carefully selected to incorporate acceptability to biological milieu. The main purpose of the work was to formulate SLNs to achieve different localisation of insulin within the SLNs, based on the three hypothetical models proposed by Muller et al. (2000). Following that, the effect of this localisation on the propensity of the SLNs to be taken up by absorptive cells was investigated. SLNs was successfully fabricated to achieve two insulin localisation models, namely the solid solution model and the core-shell model with drug-enriched shell. The zeta potential measurements was used to indirectly indicate the appropriate insulin localisation model. The zeta potential of the unloaded SLNs, insulin-loaded SLNs and surface-adsorbed insulin SLNs were recorded as -51.7 ± 1 mV, -45.8 ± 1 mV and -40.8 ± 1 mV respectively. In vitro cell studies showed a notable difference in the Caco-2 cell lines when the cells were exposed to SLNs of the two different insulin localisation models. Thus, different effects seen on the Caco-2 cells suggests that the localisation of insulin within SLNs can potentially influence its uptake, stressing the importance of characterising drug localisation in nanoparticles, as this eventually affects drug bioavailability.
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Petrache, Andreea Ivona. "Development of lipid nanodisc technology for the formulation of poorly water soluble drugs." Thesis, University of Leeds, 2016. http://etheses.whiterose.ac.uk/12968/.

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The research surrounding delivery carriers of hydrophobic drugs has evolved with the help of efficient tools brought together by nature’s most important process, self-assembly. This enabled scientists to create and tailor materials with multiple functionalities in order to suite specific needs. One such nanomaterial is the disc-shaped cargo carrier, named nanodiscs. Nanodiscs are noncovalent assemblies consisting of a phospholipid bilayer,whose hydrophobic edge is stabilized by two or more copies of membrane scaffold protein. Despite an abundance of research directed towards the development of an effective nanosystem for delivery into mammalian cells, superficial focus is given to characterizing the incorporation of hydrophobic drugs. This thesis describes the development of a simple approach to systematically study the relation between physical parameters related to loading and release of poorly water soluble drugs from nanodisc systems. For the nanodiscs reconstitution, two strategies have been studied, the first comprised of adding the protein to a mixture of lipid and detergent micelles, and second strategy involved adding protein stabilised in detergent micelles to the lipid. Two more strategies were employed for studying the loading of drugs into nanodiscs -the drugs were added either to a solution of nanodiscs, or loaded during the reconstitution of nanodiscs. The latter strategy showed an increase in drug incorporated per nanodiscs and a slower release rate. In the case of amiodarone and chlorambucil incorporation, a decrease in membrane thickness was seen to be correlated with the efficiency of drug loading within the POPC bilayer. In addition, the lipid composition within nanodiscs was varied in order to investigate its effect on nanodisc formation, drug loading and release kinetics. Finally, the protein component of empty and drug loaded nanodiscs was site-specifically modified via Sortase A mediated ligation,for traceable delivery in in vitro cell studies. Good internalisation of MSP by HeLa cells was observed when cells were treated with empty and chlorambucil loaded nanodiscs.
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Gude, Manjiri. "Effect of lipid-based formulation on the solubilization patterns if poorly water-soluble drugs." Thesis, Uppsala universitet, Institutionen för farmaci, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-445332.

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Poorly water-soluble drugs (PWSDs), to date, require advanced formulation techniques to improve solubility and achieve the required plasma concentration to show a therapeutic effect when orally administered. Lipid-based formulations (LBFs) are an enabling strategy that is being used to improve the oral delivery of PWSDs. The aim of this study was to investigate the effect of lipid-based formulation, Type IIIA-LC, on the solubilization patterns of PWSDs, namely, carvedilol and felodipine. Solubility studies, for both drugs, were performed with LBF dispersed in -1) dog intestinal fluid (DIF), and 2) water, to identify and compare the extent of solubility in different matrices, and in silico to identify interesting patterns with any correlations in experimental and computational data. Solubility studies showed that carvedilol had better solubility in LBF when compared to felodipine. Computational studies showed that both drugs solubilized in the colloid in both digested and undigested states. Effect of drug loading had no significant difference on the solubilization patterns of both drugs. The maximum drug loading done was for 100 molecules though there is the possibility of the colloid having a higher capacity. Digestion did not seem to have a significant effect on the distribution of both drugs. In vitro and in silico data were in qualitative agreement and therefore, this computational model can be further used to study the specific processes causing solubilization, improvement, and development of new LBFs.
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Rullière-Puech, Célie. "Etude des étapes de structuration du fromage fondu : impact formulation et procédé." Thesis, Montpellier 2, 2012. http://www.theses.fr/2012MON20202.

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Le fromage fondu est un produit alimentaire de seconde transformation obtenu après mélange et cuisson de fromages, additionnés éventuellement d'autres ingrédients laitiers. Ce produit, dont la consommation croit dans de nombreuses régions du monde, présente une grande variété d'applications et peut être conservé plusieurs mois à température ambiante. Cependant, les mécanismes moléculaires sous-jacents à sa structuration biochimique demeurent mal connus et sa fabrication industrielle reste souvent empirique.L'objectif général de ce travail est d'améliorer la compréhension des étapes de structuration biochimique du fromage fondu de type « portion triangulaire tartinable », au cours des étapes de sa fabrication. Dans un premier temps, les propriétés physico-chimiques des sels de fonte, additifs ajoutés au fromage fondu, ont été étudiées dans des milieux modèles de complexités croissantes, de la solution aqueuse jusqu'au lait écrémé. La composition de ces sels de fonte, leur hydrolyse après traitement thermique ainsi que leur interaction avec certains constituants laitiers ont été évaluées par deux méthodes complémentaires : la chromatographie ionique et la RMN du phosphore. Par ailleurs, il a été montré que ces sels, via la chélation du calcium, induisaient la dissociation des caséines, modifiant les propriétés d'hydratation et d'émulsification de ces dernières.Dans un deuxième temps, le rôle des sels de fonte quant à la structuration des protéines, de l'eau, des minéraux et de la matière grasse a été analysé dans des matrices plus complexes : les portions triangulaires tartinables, aux étapes clés de leur fabrication. Un mécanisme d'interaction des constituants biochimiques majoritaires a été proposé, prenant en compte l'évolution des molécules sous l'effet des contraintes physiques et chimiques appliquées au cours du procédé<br>Processed cheese is manufactured by the secondary processing food industry, by mixing and heating cheese, along with other dairy ingredients. This product, whose consumption grows in many parts of the world, has a wide variety of applications and can be stored for several months at room temperature. However, the molecular mechanisms underlying its structure remain poorly understood and industrial production is often empirical. The general objective of this work is to improve the understanding of biochemical steps structuring spreadable processed cheese during its manufacture. At first, the physico-chemical properties of additives used in processed cheese, i.e. emulsifying salts, have been studied in simplified environments of increasing complexity, from aqueous solutions to skimmed milk. The composition of theses salts, their hydrolysis after heat treatment and their interaction with some dairy constituents were assessed by two complementary methods: ion chromatography and phosphorus NMR. Moreover, it has been shown that these salts, through the calcium chelation, induced casein dissociation and modified their hydration and emulsifying properties. Then, the role of these salts on the structure and interactions between proteins, water, minerals and fat were analyzed in spreadable processed cheese, at different steps of its manufacture. A mechanism of interaction between the major biochemical constituents has been proposed, taking into account the evolution of molecules under the influence of physical and chemical constraints applied during the process
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Stevens, Phillip James. "An approach to drug formulation and targeting liposomes and lipid nanoparticles for folate receptor targeting." Connect to this title online, 2005. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1111092653.

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Thesis (Ph. D.)--Ohio State University, 2005.<br>Title from first page of PDF file. Document formatted into pages; contains xvi, 110 p.; also includes graphics (some col.) Includes bibliographical references (p. 98-110). Available online via OhioLINK's ETD Center
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Amekyeh, Hilda. "Formulation, gastrointestinal transit studies and absorption of amphotericin B-containing solid lipid nanoparticles in rats." Thesis, University of Nottingham, 2016. http://eprints.nottingham.ac.uk/33437/.

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Successful delivery of pharmaceuticals orally requires a firm understanding of how dosage forms behave during their passage through the gastrointestinal (GI) tract. In this study, the GI transit time and absorption of amphotericin B (AmB) solid lipid nanoparticles (SLN) were investigated in rats, using paracetamol (PAR) and sulphapyridine (SP) as indirect markers. A high encapsulation efficiency of 91.2% was obtained for the AmB SLNs. The SLNs were exhaustively characterised with regards to size, zeta potential (ZP), viscosity, density, migration propensity within agarose gel, in vitro drug release and morphology, to ensure similar disposition in the GI tract after simultaneous oral administration. Freeze-drying did not significantly alter the size or ZP of the AmB SLNs, and in vitro drug release from fresh and freeze-dried SLNs were identical. AmB, PAR and sulphasalazine (SSZ) (the latter being the prodrug of SP) were individually formulated into SLNs using beeswax and theobroma oil as the lipid matrix. The z-averages, polydispersity indices and ZPs of the SLNs ranged from 206.5-224.8 nm, 0.161-0.218 and |61.90|-|71.90| mV, respectively. Gel electrophoresis studies indicated a similar movement propensity among the three SLNs as their migration distances were identical (22.2-22.4 mm) within agarose gel. Scanning electron and atomic force microscopy studies revealed that all three SLNs were spherical in morphology and with similar surface characteristics. The SLNs were assessed for changes in size and surface charge on exposure to simulated GI fluids using dynamic light scattering (DLS) and nanoparticle tracking analysis (NTA). On contact with the fluids, the particles had a slight increase in size due to ingress of the dissolution media. NTA results were found to be more beneficial than DLS as the latter was biased towards larger particles that were present possibly due to aggregation. After incubation in simulated gastric fluid followed by simulated intestinal fluid (mimicking gastric emptying), all the SLNs were found to be less than 350 nm in size and neutral in charge, which are optimal attributes for intestinal absorption. Time-of-flight secondary ion mass spectroscopic (ToF-SIMS) analyses revealed minimal drug amounts on the surfaces of the particles indicating that drug location was in the core of the SLNs. A developed and validated high-performance liquid chromatography (HPLC) method for simultaneous assay of the drugs in rat plasma using piroxicam as internal standard was found to be sensitive, accurate and precise, with drug recovery from plasma exceeding 92% in each case. A pilot GI transit study conducted in rats showed that the HPLC method was appropriate for the study. In the main study, the effects of food on the transit and absorption of the AmB SLNs were investigated. The presence of food slowed the transit of the SLNs in the GI tract. The gastric transit time of the AmB SLNs was estimated indirectly using PAR and was obtained as 1.71-2.25 hr. Caecal arrival time (CAT) of the AmB SLNs was estimated using SP detection in plasma as SSZ metabolism to produce SP occurs predominantly by the activity of colonic flora. In both fasted and fed states, CAT was 1.80-1.90 hr whereas transit time through the small intestine was 1.65-1.79 hr. A delayed rate of AmB absorption was observed in the fed state however, the extent of absorption was not affected by food. The percentage AmB absorption during the fasted state in the stomach, small intestine and colon were not significantly different from absorption within the respective regions in the fed state. In both states however, absorption was highest in the colon and appeared to be a summation of small intestinal absorption plus absorption proper within the colon. The study indicated that, AmB SLNs irrespective of food status were slowly but predominantly taken up via the lymphatic route and the small intestine was the most favourable site for their absorption. The data obtained indicate that it is possible to enhance the bioavailability of AmB through its incorporation into SLNs. Further enhancement of AmB bioavailability can be achieved through appropriate formulation interventions aimed at slowing transit of the SLNs in the small intestine. Finally, being a lipid-based system, the SLNs may have a potential to reduce the nephrotoxic effects of AmB.
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Gilbert, Elodie. "Formulation et caractérisation de particules lipidiques submicroniques encapsulant des filtres ultraviolets organiques et inorganiques." Thesis, Lyon 1, 2015. http://www.theses.fr/2015LYO10324/document.

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Les écrans solaires sont des formulations dont l’application permet de protéger la peau des effets néfastes du rayonnement ultraviolet (UV) et notamment de l’apparition des cancers cutanés. Ces formulations contiennent des filtres UV organiques et/ou inorganiques. Certains filtres UV organiques sont connus pour pénétrer la peau et engendrer des réactions allergiques et photo-allergiques. De plus, certains d’entre eux peuvent engendrer des effets toxiques sur les cellules cutanées vivantes et atteindre la circulation systémique. Les filtres UV inorganiques sont la plupart du temps incorporés dans les écrans solaires sous forme de nanoparticules afin d’améliorer les qualités esthétiques des écrans solaires minéraux. Les nanoparticules utilisées comme filtres UV inorganiques exerceraient des effets toxiques sur les cellules nucléées de la peau. Les nanoparticules et nanocapsules lipidiques sont des particules lipidiques submicroniques intéressantes pour formuler les actifs pharmaceutiques et cosmétiques et notamment les filtres UV. L’objectif de ce travail était de développer des suspensions de nanoparticules lipidiques pour formuler des filtres UV inorganiques et organiques en les maintenant à la surface de la peau tout en augmentant leur efficacité photo-protectrice. Ces travaux ont permis de développer des suspensions de nanoparticules lipidiques encapsulant des filtres UV inorganiques en augmentant leur pouvoir photo-protecteur. Cette étude a également mis en évidence l’intérêt de ces suspensions de nanoparticules lipidiques pour encapsuler un filtre UV organique et limiter sa perméation percutanée tout en augmentant son efficacité filtrante dans le domaine UV<br>Sunscreens are topical formulations that protect the skin against damages induced by ultraviolet (UV) radiations and notably skin cancers formation. Those formulations contain organic and/or inorganic UV filters. Some organic UV filters are known to penetrate the skin and trigger allergic and photo-allergic cutaneous reactions. Moreover, some of them are responsible for toxic effects on skin nucleated cells and could reach systemic circulation. Nanoparticles of inorganic UV filters are often incorporated into sunscreens to improve their aesthetic qualities. Nanoparticles used as inorganic UV filters could exercise toxic effects on skin nucleated cells. Lipid nanoparticles and nanocapsules are submicronic lipid particles interesting to formulate pharmaceutical and cosmetic active compounds and notably UV filters. The aim of this work was to develop lipid nanoparticles to entrap organic and inorganic UV filters maintaining them at skin surface while increasing their photo-protection efficiency. This study permitted to develop lipid nanoparticle suspensions entrapping inorganic UV filters enhancing their photo-protection efficiency. This work also highlighted the interest of these lipid nanoparticle suspensions to entrap an organic UV filter avoiding its percutaneous permeation while enhancing its photo-protection efficiency
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Deshpande, Ameya Abhay. "Formulation, Characterization and Evaluation of Paclitaxel loaded Solid Lipid Nanoparticles Prepared by Temperature Modulated Solidification Technique." University of Toledo Health Science Campus / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=mco1436557604.

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Books on the topic "Lipid formulation"

1

Trsková, Zuzana. NMR characterization of chlorhexidine in lipid-based formulations. Brock University, Dept. of Physics, 2004.

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Hauss, David J., ed. Oral Lipid-Based Formulations. CRC Press, 2007. http://dx.doi.org/10.3109/9781420017267.

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Oral lipid-based formulations: Enhancing the bioavailability of poorly water-soluable drugs. Informa Healthcare USA, 2007.

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Hauss, David J. Oral Lipid-Based Formulations: Enhancing the Bioavailability of Poorly Water-Soluble Drugs (Drugs and the Pharmaceutical Sciences). Informa Healthcare, 2007.

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Jacobs, Samantha E., Catherine B. Small, and Thomas J. Walsh. Fungal diseases of the respiratory tract. Edited by Christopher C. Kibbler, Richard Barton, Neil A. R. Gow, Susan Howell, Donna M. MacCallum, and Rohini J. Manuel. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198755388.003.0030.

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Fungal respiratory infections are important causes of morbidity and mortality in immunocompromised patients. Invasive aspergillosis remains the most common invasive fungal infection whereas other filamentous fungi, such as Fusarium spp., Mucorales, and Scedosporium spp., are increasing in frequency, particularly in neutropenic hosts. Endemic mycoses, including those due to Histoplasma capsulatum, Coccidioides spp., and Talaromyces marneffei, are increasingly prevalent in patients with cell-mediated immunodeficiencies in respective geographic regions. Culture remains the gold standard of diagnosis but has limited sensitivity and often requires invasive procedures. Non-invasive diagnostic tests, including the serum sandwich enzyme immunoassay for the detection of galactomannan, the (1→3)-β‎-D-glucan assay, and molecular amplification methods have been developed to facilitate early and accurate diagnosis. Successful therapy depends upon early initiation of antifungal agents and reversal of immunosuppression. Lipid formulations of amphotericin B and newer generation triazoles including voriconazole, posaconazole, and isavuconazole have expanded the ability to treat multi-drug resistant pathogens more effectively and with less toxicity.
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Casaer, Michael P., and Greet Van den Berghe. Nutrition support in acute cardiac care. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199687039.003.0032.

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Malnutrition in cardiac and critical illness is associated with a compromised clinical outcome. The aim of nutrition therapy is to prevent these complications and particularly to attenuate lean tissue wasting and the loss of muscle force and of physical function. During the last decade, several well-powered randomized controlled nutrition trials have been performed. Their results challenge the existing nutrition practices in critically ill patients. Enhancing the nutritional intake and the administration of specialized formulations failed to evoke clinical benefit. Some interventions even provoked an increased mortality or a delayed recovery. These unexpected new findings might be, in part, caused by an important leap forward in the methodological quality in the recent trials. Perhaps reversing early catabolism in the critically ill patient by nutrition or anabolic interventions is impossible or even inappropriate. Nutrients effectively suppress the catabolic intracellular autophagy pathway. But autophagy is crucial for cellular integrity and function during metabolic stress, and consequently its inhibition early in critical illness might be deleterious. Evidence from large nutrition trials, particularly in acute cardiac illness, is scarce. Nutrition therapy is therefore focused on avoiding iatrogenic harm. Some enteral nutrition is administered if possible and eventually temporary hypocaloric feeding is tolerated. Above all, the refeeding syndrome and other nutrition-related complications should be prevented. There is no indication for early parenteral nutrition, increased protein doses, specific amino acids, or modified lipids in critical illness.
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Casaer, Michael P., and Greet Van den Berghe. Nutrition support in acute cardiac care. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199687039.003.0032_update_001.

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Malnutrition in cardiac and critical illness is associated with a compromised clinical outcome. The aim of nutrition therapy is to prevent these complications and particularly to attenuate lean tissue wasting and the loss of muscle force and of physical function. During the last decade, several well-powered randomized controlled nutrition trials have been performed. Their results challenge the existing nutrition practices in critically ill patients. Enhancing the nutritional intake and the administration of specialized formulations failed to evoke clinical benefit. Some interventions even provoked an increased mortality or a delayed recovery. These unexpected new findings might be, in part, caused by an important leap forward in the methodological quality in the recent trials. Perhaps reversing early catabolism in the critically ill patient by nutrition or anabolic interventions is impossible or even inappropriate. Nutrients effectively suppress the catabolic intracellular autophagy pathway. But autophagy is crucial for cellular integrity and function during metabolic stress, and consequently its inhibition early in critical illness might be deleterious. Evidence from large nutrition trials, particularly in acute cardiac illness, is scarce. Nutrition therapy is therefore focused on avoiding iatrogenic harm. Some enteral nutrition is administered if possible and eventually temporary hypocaloric feeding is tolerated. Above all, the refeeding syndrome and other nutrition-related complications should be prevented. There is no indication for early parenteral nutrition, increased protein doses, specific amino acids, or modified lipids in critical illness.
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Casaer, Michael P., and Greet Van den Berghe. Nutrition support in acute cardiac care. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199687039.003.0032_update_002.

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Malnutrition in cardiac and critical illness is associated with a compromised clinical outcome. The aim of nutrition therapy is to prevent these complications and particularly to attenuate lean tissue wasting and the loss of muscle force and of physical function. During the last decade, several well-powered randomized controlled nutrition trials have been performed. Their results challenge the existing nutrition practices in critically ill patients. Enhancing the nutritional intake and the administration of specialized formulations failed to evoke clinical benefit. Some interventions even provoked an increased mortality or a delayed recovery. These unexpected new findings might be, in part, caused by an important leap forward in the methodological quality in the recent trials. Perhaps reversing early catabolism in the critically ill patient by nutrition or anabolic interventions is impossible or even inappropriate. Nutrients effectively suppress the catabolic intracellular autophagy pathway. But autophagy is crucial for cellular integrity and function during metabolic stress, and consequently its inhibition early in critical illness might be deleterious. Evidence from large nutrition trials, particularly in acute cardiac illness, is scarce. Nutrition therapy is therefore focused on avoiding iatrogenic harm. Some enteral nutrition is administered if possible and eventually temporary hypocaloric feeding is tolerated. Above all, the refeeding syndrome and other nutrition-related complications should be prevented. There is no indication for early parenteral nutrition, increased protein doses, specific amino acids, or modified lipids in critical illness.
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Book chapters on the topic "Lipid formulation"

1

Mojumdar, Enamul Haque, and Joke A. Bouwstra. "Stratum Corneum Lipid Composition and Organization." In Cosmetic Formulation. CRC Press, 2019. http://dx.doi.org/10.1201/9780429190674-3.

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Golding, M. "The Colloidal State and its Relationship to Lipid Digestion." In Formulation Engineering of Foods. John Wiley & Sons, Ltd, 2013. http://dx.doi.org/10.1002/9781118597651.ch10.

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Rosiaux, Yvonne, Vincent Jannin, Sophie Hughes, and Delphine Marchaud. "Solid Lipid Excipients as Matrix Agents for Sustained Drug Delivery." In Excipient Applications in Formulation Design and Drug Delivery. Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-20206-8_9.

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Öztürk Öncel, M. Özgen, Bora Garipcan, and Fatih Inci. "Biomedical Applications: Liposomes and Supported Lipid Bilayers for Diagnostics, Theranostics, Imaging, Vaccine Formulation, and Tissue Engineering." In Biomimetic Lipid Membranes: Fundamentals, Applications, and Commercialization. Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-11596-8_8.

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LaFountaine, Justin, Ping Gao, and Robert O. Williams. "Lipid-Based Formulations." In Formulating Poorly Water Soluble Drugs. Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-42609-9_7.

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Tiberg, Fredrik, Markus Johnsson, Catalin Nistor, and Fredrik Joabsson. "Self-Assembling Lipid Formulations." In Long Acting Injections and Implants. Springer US, 2011. http://dx.doi.org/10.1007/978-1-4614-0554-2_16.

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Cafiero, Stephen M. "Chapter 11 Dissolution of Lipid-Based Drug Formulations." In Poorly Soluble Drugs. Pan Stanford Publishing, 2017. http://dx.doi.org/10.1201/9781315364537-12.

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Gao, Ping. "Design and Development of Self-Emulsifying Lipid Formulations for Improving Oral Bioavailability of Poorly Water-Soluble and Lipophilic Drugs." In Formulating Poorly Water Soluble Drugs. Springer New York, 2011. http://dx.doi.org/10.1007/978-1-4614-1144-4_7.

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Molina, Marion dC, Nicole M. Payton, and Thomas J. Anchordoquy. "Stabilization of Plasmid DNA and Lipid-Based Therapeutics as Dehydrated Formulations." In Lyophilized Biologics and Vaccines. Springer New York, 2015. http://dx.doi.org/10.1007/978-1-4939-2383-0_10.

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Lopez-Martinez, Leticia Xochitl, José Juan Buenrostro-Figueroa, Edwin Rojo-Gutiérrez, Hugo Sergio Garcia-Galindo, and Ramiro Baeza-Jiménez. "Lipids as Components for Formulation of Functional Foods: Recent Trends." In Food Microbiology and Biotechnology. Apple Academic Press, 2020. http://dx.doi.org/10.1201/9780429322341-16.

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Conference papers on the topic "Lipid formulation"

1

Chaudhari, Paresh, Rolin Wade, Jaime Natoli, Robert Taylor, Brian Nathanson, and David Horn. "Lower Nephrotoxicity, Adverse Effects And Hospital Length Of Stay With Exclusive Lipid Formulations Of Amphotericin B Vs. Amphotericin B Deoxycholate Followed By Lipid Formulation Amphotericin B." In American Thoracic Society 2012 International Conference, May 18-23, 2012 • San Francisco, California. American Thoracic Society, 2012. http://dx.doi.org/10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a6091.

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Rosa, Debora Morais, and Wanderley Pereira Oliveira. "Spray drying of lipid nanosystems (SLN and NLC) loaded with Syzygium aromaticum essential oil." In 21st International Drying Symposium. Universitat Politècnica València, 2018. http://dx.doi.org/10.4995/ids2018.2018.7554.

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A quality by design approach was used to investigate the influence of formulation composition and spray drying conditions on physicochemical properties of redispersable lipid based nanosystems loaded with Syzygium aromaticum essential oil. Four critical independent variables were studied: presence or absence of the liquid lipid oleic acid (0% - 1%), of the cationic surfactant CTAB (0% and 1%), inlet drying temperature (60 ºC -80 ºC), and ratio of the drying aids (ADJ) regarded to total formulation constituents weight (1:1 and 2:1). Resuls showed the production of spray dried redispersable lipid systems loaded with essential is feasible under very restrict conditions. Keywords: Encapsulation; lipid systems; essential oil; spray drying; redispersable.
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Gonnet, Maud, Zina Koob, Thomas Perrier, Francis Bichat, Olivier Meyer, and Marc Hillairet de Boisferon. "Abstract 2895: Enhanced paclitaxel delivery to tumors using a new lipid nanocapsule-based formulation." In Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-2895.

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Podaralla, Satheesh K., Ranjith Averineni, Omathanu Perumal, and Chandradhar Dwivedi. "Abstract 5709: Formulation development and evaluation of nanostructured lipid carriers for topical delivery of honokiol." In Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-5709.

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Chen, Yan, Lei Zhou, Ling Yuan, Zhenhai Zhang, and Qingqing Wu. "Formulation, Characterization and Evaluation of the in Vitro Skin Permeation of Nanostructured Lipid Carriers Encapsulated Tripterine." In 2012 International Conference on Biomedical Engineering and Biotechnology (iCBEB). IEEE, 2012. http://dx.doi.org/10.1109/icbeb.2012.227.

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Piazzini, V., G. Graverini, G. Vanti, et al. "SOLID LIPID NANOPARTICLES FOR ORAL DELIVERY OF SILIBININ: FORMULATION, CHARACTERIZATION AND EVALUATION USING PAMPA AND CACO-2 CELL MODELS." In GA 2017 – Book of Abstracts. Georg Thieme Verlag KG, 2017. http://dx.doi.org/10.1055/s-0037-1608582.

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Tirunagaru, Vijaya G., Arnab Roy Chowdhury, Jeyaraj Athisayamani Duraiswamy, et al. "Abstract 1661: Development of lipid-based nanosuspension formulation of first-in-class PLK2 inhibitor GBO-006 to treat triple-negative breast cancer." In Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-1661.

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Semple, Sean C., Adam D. Judge, Marjorie Robbins, et al. "Abstract 2829: Preclinical characterization of TKM-080301, a lipid nanoparticle formulation of a small interfering RNA directed against polo-like kinase 1." In Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1538-7445.am2011-2829.

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Alapati, Raghava, Dorel Moldovan, and Ram Devireddy. "Atomistic Simulation of Pore Formation in Lipid Bilayers in the Presence of Dimethylsulfoxide: Further Evidence for Entropic Driven Pore Formation." In ASME 2008 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2008. http://dx.doi.org/10.1115/sbc2008-192793.

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In a recent study, Moldovan et al [1] have demonstrated that in the presence of 11.3 mol% dimethylsulfoxide (DMSO) a pore can nucleate and grow spontaneously in a lipid bilayer even in the absence of an externally applied stresses or electric field. The authors rationalized the spontaneous pore nucleation, in the absence of any external driving force, by considering the combined effect of the entropy of pore shape fluctuation and the significant decrease of the bilayer line tension in the presence of DMSO. Building on the classical nucleation theory developed three decades ago by Lister [2] the authors propose a new formulation for the bilayer free energy that incorporates the pore shape configurational entropy. According to this study, in the presence of DMSO, the pore nucleates spontaneously and grows provided the bilayer line tension decreases below a threshold value, λ. In this study we report our recent simulation results on the effect of DMSO concentration on both bilayer line tension and bilayer structural stability with respect to pore nucleation. The lipid bilayer systems investigated in this study by molecular dynamics (MD) consists of 96 molecules (48 in each leaflet) of dimyristoylphosphatidylcholine (DMPC) immersed in DMSO-water solutions at various concentrations. In all MD simulations reported the bilayer systems were followed over 100 ns. Our simulations results indicate the existence of a critical DMSO concentration below which there are no pores nucleated in the lipid bilayers. Our findings corroborate and complement the entropy-based pore nucleation model proposed earlier by Moldovan et al. [1].
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Joshi‐Hangal, Rajashree, Chunlin Tang, Inloes Roger, et al. "Abstract B209: A self‐emulsifying lipid suspension formulation enhances oral bioavailability of MP‐470 in a randomized two‐way crossover study in healthy male subjects." In Abstracts: AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics--Nov 15-19, 2009; Boston, MA. American Association for Cancer Research, 2009. http://dx.doi.org/10.1158/1535-7163.targ-09-b209.

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