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Journal articles on the topic 'Lipid Membranes - Molecular Reorganization'

Author: Grafiati

Published: 4 June 2021

Last updated: 6 September 2023

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1

Sadžak, Anja, Janez Mravljak, Nadica Maltar-Strmečki, et al. "The Structural Integrity of the Model Lipid Membrane during Induced Lipid Peroxidation: The Role of Flavonols in the Inhibition of Lipid Peroxidation." Antioxidants 9, no. 5 (2020): 430. http://dx.doi.org/10.3390/antiox9050430.

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The structural integrity, elasticity, and fluidity of lipid membranes are critical for cellular activities such as communication between cells, exocytosis, and endocytosis. Unsaturated lipids, the main components of biological membranes, are particularly susceptible to the oxidative attack of reactive oxygen species. The peroxidation of unsaturated lipids, in our case 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC), induces the structural reorganization of the membrane. We have employed a multi-technique approach to analyze typical properties of lipid bilayers, i.e., roughness, thickness, elas

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Sasaki, Darryl Y., Tina A. Waggoner, Julie A. Last, and Todd M. Alam. "Crown Ether Functionalized Lipid Membranes: Lead Ion Recognition and Molecular Reorganization." Langmuir 18, no. 9 (2002): 3714–21. http://dx.doi.org/10.1021/la011651r.

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Pathak, Prabhat Kumar, Shuxia Peng, Xiangzhi Meng, et al. "Structure of a lipid-bound viral membrane assembly protein reveals a modality for enclosing the lipid bilayer." Proceedings of the National Academy of Sciences 115, no. 27 (2018): 7028–32. http://dx.doi.org/10.1073/pnas.1805855115.

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Cellular membranes are maintained as closed compartments, broken up only transiently during membrane reorganization or lipid transportation. However, open-ended membranes, likely derived from scissions of the endoplasmic reticulum, persist in vaccinia virus-infected cells during the assembly of the viral envelope. A group of viral membrane assembly proteins (VMAPs) were identified as essential for this process. To understand the mechanism of VMAPs, we determined the 2.2-Å crystal structure of the largest member, named A6, which is a soluble protein with two distinct domains. The structure of A

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Ponmalar, Ilanila I., Ramesh Cheerla, K. Ganapathy Ayappa, and Jaydeep K. Basu. "Correlated protein conformational states and membrane dynamics during attack by pore-forming toxins." Proceedings of the National Academy of Sciences 116, no. 26 (2019): 12839–44. http://dx.doi.org/10.1073/pnas.1821897116.

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Pore-forming toxins (PFTs) are a class of proteins implicated in a wide range of virulent bacterial infections and diseases. These toxins bind to target membranes and subsequently oligomerize to form functional pores that eventually lead to cell lysis. While the protein undergoes large conformational changes on the bilayer, the connection between intermediate oligomeric states and lipid reorganization during pore formation is largely unexplored. Cholesterol-dependent cytolysins (CDCs) are a subclass of PFTs widely implicated in food poisoning and other related infections. Using a prototypical

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HUANG, Huan, Friedhelm SCHROEDER, Mary K. ESTES, Tanya McPHERSON, and Judith M. BALL. "Interaction(s) of rotavirus non-structural protein 4 (NSP4) C-terminal peptides with model membranes." Biochemical Journal 380, no. 3 (2004): 723–33. http://dx.doi.org/10.1042/bj20031789.

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Rotavirus is the major cause of dehydrating gastroenteritis in children and young animals. NSP4 (non-structural protein 4), a rotaviral non-structural glycoprotein and a peptide NSP4114–135 (DKLTTREIEQVELLKRIYDKLT), corresponding to NSP4 amino acids 114–135, induce diarrhoeal disease in a neonatal mouse model and interact with model membranes that mimic caveolae. Correlation of the mechanisms of diarrhoea induction and membrane interactions by NSP4 protein and peptide remain unclear. Several additional NSP4 peptides were synthesized and their interactions with membranes studied by (i) CD, (ii)

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Venugopal, Sathvika, Melanie Galano, Rachel Chan, et al. "Dynamic Remodeling of Membranes and Their Lipids during Acute Hormone-Induced Steroidogenesis in MA-10 Mouse Leydig Tumor Cells." International Journal of Molecular Sciences 22, no. 5 (2021): 2554. http://dx.doi.org/10.3390/ijms22052554.

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Lipids play essential roles in numerous cellular processes, including membrane remodeling, signal transduction, the modulation of hormone activity, and steroidogenesis. We chose steroidogenic MA-10 mouse tumor Leydig cells to investigate subcellular lipid localization during steroidogenesis. Electron microscopy showed that cAMP stimulation increased associations between the plasma membrane (PM) and the endoplasmic reticulum (ER) and between the ER and mitochondria. cAMP stimulation also increased the movement of cholesterol from the PM compared to untreated cells, which was partially inhibited

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Glushakova, S. E., A. L. Ksenofontov, N. V. Fedorova, et al. "A model for the study of the mechanism of a low pH-induced interaction of the virus fusion proteins and cell membranes." Bioscience Reports 11, no. 3 (1991): 131–37. http://dx.doi.org/10.1007/bf01182481.

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A model is proposed for the study of molecular mechanisms of a low pH-induced interaction of fusion proteins of enveloped viruses and cell membranes. The model consists of large monolamellar liposomes containing ionophore nigericin in their membranes and ectodomains of fusion protein in their inner space. The process of interaction of the protein with the lipid bilayer is triggered by acidification of the liposomal constituents to the pH of fusion with the help of nigericin by adding citric acid to the outer medium. To visualize the protein structural reorganization, the tritium planigraphy wa

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Nokhsorov, Vasiliy V., Svetlana V. Senik, Valentina E. Sofronova, et al. "Role of Lipids of the Evergreen Shrub Ephedra monosperma in Adaptation to Low Temperature in the Cryolithozone." Plants 12, no. 1 (2022): 15. http://dx.doi.org/10.3390/plants12010015.

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Lipids are the fundamental components of cell membranes and they play a significant role in their integrity and fluidity. The alteration in lipid composition of membranes has been reported to be a major response to abiotic environmental stresses. Seasonal dynamics of membrane lipids in the shoots of Ephedra monosperma J.G. Gmel. ex C.A. Mey. growing in natural conditions of permafrost ecosystems was studied using HPTLC, GC-MS and ESI-MS. An important role of lipid metabolism was established during the autumn-winter period when the shoots of the evergreen shrub were exposed to low positive (3.6

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LAULAGNIER, Karine, Claude MOTTA, Safouane HAMDI, et al. "Mast cell- and dendritic cell-derived exosomes display a specific lipid composition and an unusual membrane organization." Biochemical Journal 380, no. 1 (2004): 161–71. http://dx.doi.org/10.1042/bj20031594.

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Exosomes are small vesicles secreted from multivesicular bodies, which are able to stimulate the immune system leading to tumour cell eradication. We have analysed lipids of exosomes secreted either upon stimulation from rat mast cells (RBL-2H3 cells), or constitutively from human dendritic cells. As compared with parent cells, exosomes displayed an enrichment in sphingomyelin, but not in cholesterol. Phosphatidylcholine content was decreased, but an enrichment was noted in disaturated molecular species as in phosphatidylethanolamines. Lyso(bis)phosphatidic acid was not enriched in exosomes as

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Sych, Taras, Yves Mély, and Winfried Römer. "Lipid self-assembly and lectin-induced reorganization of the plasma membrane." Philosophical Transactions of the Royal Society B: Biological Sciences 373, no. 1747 (2018): 20170117. http://dx.doi.org/10.1098/rstb.2017.0117.

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The plasma membrane represents an outstanding example of self-organization in biology. It plays a vital role in protecting the integrity of the cell interior and regulates meticulously the import and export of diverse substances. Its major building blocks are proteins and lipids, which self-assemble to a fluid lipid bilayer driven mainly by hydrophobic forces. Even if the plasma membrane appears—globally speaking—homogeneous at physiological temperatures, the existence of specialized nano- to micrometre-sized domains of raft-type character within cellular and synthetic membrane systems has bee

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Krokidis, Marios G., Maria Louka, Eleni K. Efthimiadou, et al. "Membrane Lipidome Reorganization and Accumulation of Tissue DNA Lesions in Tumor-Bearing Mice: An Exploratory Study." Cancers 11, no. 4 (2019): 480. http://dx.doi.org/10.3390/cancers11040480.

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Increased rates of reactive oxygen/nitrogen species (ROS/RNS) are involved in almost all cancer types, associated with tumor development and progression, causing damage to biomolecules such as proteins, nucleic acids and membrane lipids, in different biological compartments. We used a human tumor xenograft mouse model to evaluate for the first time in parallel the remodeling of fatty acid moieties in erythrocyte membrane phospholipids and the level of ROS-induced DNA lesions in liver and kidney tissues. Using liquid chromatography tandem mass spectrometry the 5’R and 5’S diastereoisomers of 5’

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Srivatsav, Aswin T., Manjari Mishra, and Shobhna Kapoor. "Small-Molecule Modulation of Lipid-Dependent Cellular Processes against Cancer: Fats on the Gunpoint." BioMed Research International 2018 (August 15, 2018): 1–17. http://dx.doi.org/10.1155/2018/6437371.

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Lipid cell membrane composed of various distinct lipids and proteins act as a platform to assemble various signaling complexes regulating innumerous cellular processes which are strongly downregulated or altered in cancer cells emphasizing the still-underestimated critical function of lipid biomolecules in cancer initiation and progression. In this review, we outline the current understanding of how membrane lipids act as signaling hot spots by generating distinct membrane microdomains called rafts to initiate various cellular processes and their modulation in cancer phenotypes. We elucidate t

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Santos, Filipa C., Andreia S. Fernandes, Catarina A. C. Antunes, et al. "Reorganization of plasma membrane lipid domains during conidial germination." Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1862, no. 2 (2017): 156–66. http://dx.doi.org/10.1016/j.bbalip.2016.10.011.

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14

Gaussier, Hélène, Thierry Lefèvre, and Muriel Subirade. "Binding of Pediocin PA-1 with Anionic Lipid Induces Model Membrane Destabilization." Applied and Environmental Microbiology 69, no. 11 (2003): 6777–84. http://dx.doi.org/10.1128/aem.69.11.6777-6784.2003.

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ABSTRACT To obtain molecular insights into the action mode of antimicrobial activity of pediocin PA-1, the interactions between this bacteriocin and dimyristoylphosphatidylcholine (DMPC) or dimyristoylphosphatidylglycerol (DMPG) model membranes have been investigated in D2O at pD 6 by Fourier transform infrared spectroscopy. The interactions were monitored with respect to alteration of the secondary structure of pediocin, as registered by the amide I′ band, and phospholipid conformation, as revealed by the methylene νs(CH2) and carbonyl ν(C═;O) stretching vibrations. The results show that no i

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15

Macdonald, Patrick J., Natalia Stepanyants, Niharika Mehrotra, et al. "A dimeric equilibrium intermediate nucleates Drp1 reassembly on mitochondrial membranes for fission." Molecular Biology of the Cell 25, no. 12 (2014): 1905–15. http://dx.doi.org/10.1091/mbc.e14-02-0728.

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The GTPase dynamin-related protein 1 (Drp1) catalyzes mitochondrial division, but the mechanisms remain poorly understood. Much of what is attributed to Drp1’s mechanism of action in mitochondrial membrane fission parallels that of prototypical dynamin in endocytic vesicle scission. Unlike the case for dynamin, however, no lipid target for Drp1 activation at the mitochondria has been identified. In addition, the oligomerization properties of Drp1 have not been well established. We show that the mitochondria-specific lipid cardiolipin is a potent stimulator of Drp1 GTPase activity, as well as o

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Villalba, Martin, Kun Bi, Fernando Rodriguez, Yoshihiko Tanaka, Stephen Schoenberger, and Amnon Altman. "Vav1/Rac-dependent actin cytoskeleton reorganization is required for lipid raft clustering in T cells." Journal of Cell Biology 155, no. 3 (2001): 331–38. http://dx.doi.org/10.1083/jcb.200107080.

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Formation of the immunological synapse (IS) in T cells involves large scale molecular movements that are mediated, at least in part, by reorganization of the actin cytoskeleton. Various signaling proteins accumulate at the IS and are localized in specialized membrane microdomains, known as lipid rafts. We have shown previously that lipid rafts cluster and localize at the IS in antigen-stimulated T cells. Here, we provide evidence that lipid raft polarization to the IS depends on an intracellular pathway that involves Vav1, Rac, and actin cytoskeleton reorganization. Thus, lipid rafts did not t

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Vitrac, Heidi, David M. MacLean, Vasanthi Jayaraman, Mikhail Bogdanov, and William Dowhan. "Dynamic membrane protein topological switching upon changes in phospholipid environment." Proceedings of the National Academy of Sciences 112, no. 45 (2015): 13874–79. http://dx.doi.org/10.1073/pnas.1512994112.

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A fundamental objective in membrane biology is to understand and predict how a protein sequence folds and orients in a lipid bilayer. Establishing the principles governing membrane protein folding is central to understanding the molecular basis for membrane proteins that display multiple topologies, the intrinsic dynamic organization of membrane proteins, and membrane protein conformational disorders resulting in disease. We previously established that lactose permease of Escherichia coli displays a mixture of topological conformations and undergoes postassembly bidirectional changes in orient

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18

Lee, Jia-Lin, Mei-Jung Wang, Putty-Reddy Sudhir, and Jeou-Yuan Chen. "CD44 Engagement Promotes Matrix-Derived Survival through the CD44-SRC-Integrin Axis in Lipid Rafts." Molecular and Cellular Biology 28, no. 18 (2008): 5710–23. http://dx.doi.org/10.1128/mcb.00186-08.

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ABSTRACT CD44 is present in detergent-resistant, cholesterol-rich microdomains, called lipid rafts, in many types of cells. However, the functional significance of CD44 in lipid rafts is still unknown. We have previously demonstrated that osteopontin-mediated engagement of CD44 spliced variant isoforms promotes an extracellular matrix-derived survival signal through integrin activation. By using a series of CD44 mutants and pharmacological inhibitors selectively targeted to various cellular pathways, we show in this study that engagement of CD44 induces lipid raft coalescence to facilitate a C

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19

Herrmann, Andreas, Thomas Groth, Günter Lassmann, Axel-M. Ladhoff, and Bärbel Hillebrecht. "Structural alterations of the human erythrocyte membrane upon influenza virus attachment." Bioscience Reports 6, no. 1 (1986): 45–55. http://dx.doi.org/10.1007/bf01145178.

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Molecular events on the human erythrocyte membrane subsequent to influence virus binding were investigated by electron spin resonance (ESR) measurements after spin labeling of the cell membrane at different positions. Virus binding affected the glycocalyx structure as well as the physical state of the cytoskeleton at the inner leaflet, but not the lipid phase. A lateral reorganization of spin-labeled glycophorin was not indicated after virus attachment.

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20

Cevc, Gregor, Ulrich Vierl, and Holger Richardsen. "Molecular conformation and structural reorganization near the lipid bilayer surface: biophysical studies of ‘long-circulating’ and DNA-carrying membranes." Advanced Drug Delivery Reviews 24, no. 2-3 (1997): 233. http://dx.doi.org/10.1016/s0169-409x(96)00462-0.

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21

Kläsener, Kathrin, and Michael Reth. "Wie das Membranprotein CD20 humane B-Lymphozyten ruhig hält." BIOspektrum 28, no. 6 (2022): 608–11. http://dx.doi.org/10.1007/s12268-022-1835-1.

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AbstractThe membrane protein CD20 of B lymphocytes is the target of Rituximab (RTX), the first successful therapeutic antibody. The biological function of CD20 was a mystery so far. We found that loss of CD20 leads to the reorganization of a protein/lipid nanodomain on the plasma membrane, the activation of human B cells, and their differentiation into antibody-producing plasma cells. These finding shed new light on the functional membrane organization and the therapeutic mechanism of anti-CD20 antibodies.

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Raducka-Jaszul, Olga, Karolina Wójtowicz, Aleksander F. Sikorski, Giovanna Chimini, Yannick Hamon, and Tomasz Trombik. "Molecular Diffusion of ABCA1 at the Cell Surface of Living Cells Assessed by svFCS." Membranes 11, no. 7 (2021): 498. http://dx.doi.org/10.3390/membranes11070498.

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Extensive studies showed the crucial role of ATP binding cassette (ABC) transporter ABCA1 in organizing the lipid microenvironment at the plasma membrane (PM) of living cells. However, the exact role of this protein in terms of lipid redistribution and lateral reorganization of the PM is still being discussed. Here, we took advantage of the spot variation fluorescence correlation spectroscopy (svFCS) to investigate the molecular dynamics of the ABCA1 expressed at the PM of Chinese hamster ovary cells (CHO-K1). We confirmed that this protein is strongly confined into the raft nanodomains. Next,

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23

Anderson, A. L., L. Mitchell, E. A. McLaughlin, M. K. O'Bryan, R. J. Aitken, and B. Nixon. "322. PROTEOMIC AND FUNCTIONAL ANALYSIS OF HUMAN SPERM DETERGENT RESISTANT MEMBRANES." Reproduction, Fertility and Development 22, no. 9 (2010): 122. http://dx.doi.org/10.1071/srb10abs322.

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Mammalian spermatozoa attain the ability to fertilize an oocyte as they negotiate the female reproductive tract. This acquisition of functional competence is preceded by an intricate cascade of biochemical and functional changes collectively known as ‘capacitation’. Among the universal correlates of the capacitation process is a remarkable remodeling of the lipid and protein architecture of the sperm plasma membrane. While the fundamental mechanisms that underpin this dynamic reorganization remain enigmatic, emerging evidence has raised the prospect that it may be coordinated, at least in part

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Choromańska, Anna, Agnieszka Chwiłkowska, Julita Kulbacka, et al. "Modifications of Plasma Membrane Organization in Cancer Cells for Targeted Therapy." Molecules 26, no. 7 (2021): 1850. http://dx.doi.org/10.3390/molecules26071850.

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Modifications of the composition or organization of the cancer cell membrane seem to be a promising targeted therapy. This approach can significantly enhance drug uptake or intensify the response of cancer cells to chemotherapeutics. There are several methods enabling lipid bilayer modifications, e.g., pharmacological, physical, and mechanical. It is crucial to keep in mind the significance of drug resistance phenomenon, ion channel and specific receptor impact, and lipid bilayer organization in planning the cell membrane-targeted treatment. In this review, strategies based on cell membrane mo

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Szlasa, Wojciech, Aleksander Kiełbik, Anna Szewczyk, et al. "Atorvastatin Modulates the Efficacy of Electroporation and Calcium Electrochemotherapy." International Journal of Molecular Sciences 22, no. 20 (2021): 11245. http://dx.doi.org/10.3390/ijms222011245.

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Electroporation is influenced by the features of the targeted cell membranes, e.g., the cholesterol content and the surface tension of the membrane. The latter is eventually affected by the organization of actin fibers. Atorvastatin is a statin known to influence both the cholesterol content and the organization of actin. This work analyzes the effects of the latter on the efficacy of electroporation of cancer cells. In addition, herein, electroporation was combined with calcium chloride (CaEP) to assess as well the effects of the statin on the efficacy of electrochemotherapy. Cholesterol-rich

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Hellwing, Christine, Axel Schoeniger, Claudia Roessler, Anja Leimert, and Julia Schumann. "Lipid raft localization of TLR2 and its co-receptors is independent of membrane lipid composition." PeerJ 6 (January 5, 2018): e4212. http://dx.doi.org/10.7717/peerj.4212.

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BackgroundToll like receptors (TLRs) are an important and evolutionary conserved class of pattern recognition receptors associated with innate immunity. The recognition of Gram-positive cell wall constituents strongly depends on TLR2. In order to be functional, TLR2 predominantly forms a heterodimer with TLR1 or TLR6 within specialized membrane microdomains, the lipid rafts. The membrane lipid composition and the physicochemical properties of lipid rafts are subject to modification by exogenous fatty acids. Previous investigations of our group provide evidence that macrophage enrichment with p

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Huang, Dingquan, Yanbiao Sun, Zhiming Ma, et al. "Salicylic acid-mediated plasmodesmal closure via Remorin-dependent lipid organization." Proceedings of the National Academy of Sciences 116, no. 42 (2019): 21274–84. http://dx.doi.org/10.1073/pnas.1911892116.

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Plasmodesmata (PD) are plant-specific membrane-lined channels that create cytoplasmic and membrane continuities between adjacent cells, thereby facilitating cell–cell communication and virus movement. Plant cells have evolved diverse mechanisms to regulate PD plasticity in response to numerous environmental stimuli. In particular, during defense against plant pathogens, the defense hormone, salicylic acid (SA), plays a crucial role in the regulation of PD permeability in a callose-dependent manner. Here, we uncover a mechanism by which plants restrict the spreading of virus and PD cargoes usin

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Makowski, Marcin, Mário R. Felício, Isabel C. M. Fensterseifer, Octávio L. Franco, Nuno C. Santos, and Sónia Gonçalves. "EcDBS1R4, an Antimicrobial Peptide Effective against Escherichia coli with In Vitro Fusogenic Ability." International Journal of Molecular Sciences 21, no. 23 (2020): 9104. http://dx.doi.org/10.3390/ijms21239104.

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Discovering antibiotic molecules able to hold the growing spread of antimicrobial resistance is one of the most urgent endeavors that public health must tackle. The case of Gram-negative bacterial pathogens is of special concern, as they are intrinsically resistant to many antibiotics, due to an outer membrane that constitutes an effective permeability barrier. Antimicrobial peptides (AMPs) have been pointed out as potential alternatives to conventional antibiotics, as their main mechanism of action is membrane disruption, arguably less prone to elicit resistance in pathogens. Here, we investi

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Du, Guangwei, and Michael A. Frohman. "A Lipid-signaled Myosin Phosphatase Surge Disperses Cortical Contractile Force Early in Cell Spreading." Molecular Biology of the Cell 20, no. 1 (2009): 200–208. http://dx.doi.org/10.1091/mbc.e08-06-0555.

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When cells cease migrating through the vasculature, adhere to extracellular matrix, and begin to spread, they exhibit rapid changes in contraction and relaxation at peripheral regions newly contacting the underlying substrata. We describe here a requirement in this process for myosin II disassembly at the cell cortex via the action of myosin phosphatase (MP), which in turn is regulated by a plasma membrane signaling lipid. Cells in suspension exhibit high levels of activity of the signaling enzyme phospholipase D2 (PLD2), elevating production of the lipid second messenger phosphatidic acid (PA

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Cheerla, Ramesh, and K. Ganapathy Ayappa. "Molecular Dynamics Study of Lipid and Cholesterol Reorganization Due to Membrane Binding and Pore Formation by Listeriolysin O." Journal of Membrane Biology 253, no. 6 (2020): 535–50. http://dx.doi.org/10.1007/s00232-020-00148-9.

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Yamamoto, Masaya, Mark Z. Chen, Ying-Jie Wang та ін. "Hypertonic Stress Increases Phosphatidylinositol 4,5-Bisphosphate Levels by Activating PIP5KIβ". Journal of Biological Chemistry 281, № 43 (2006): 32630–38. http://dx.doi.org/10.1074/jbc.m605928200.

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Hyperosmotic stress increases phosphoinositide levels, reorganizes the actin cytoskeleton, and induces multiple acute and adaptive physiological responses. Here we showed that phosphatidylinositol 4,5-bisphosphate (PIP2) level increased rapidly in HeLa cells during hypertonic treatment. Depletion of the human type I phosphatidylinositol 4-phosphate 5-kinase β isoform (PIP5KIβ) by RNA interference impaired both the PIP2 and actin cytoskeletal responses. PIP5KIβ was recruited to membranes and was activated by hypertonic stress through Ser/Thr dephosphorylation. Calyculin A, a protein phosphatase

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Tiszlavicz, Ádám, Imre Gombos, Mária Péter, et al. "Distinct Cellular Tools of Mild Hyperthermia-Induced Acquired Stress Tolerance in Chinese Hamster Ovary Cells." Biomedicines 10, no. 5 (2022): 1172. http://dx.doi.org/10.3390/biomedicines10051172.

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Mild stress could help cells to survive more severe environmental or pathophysiological conditions. In the current study, we investigated the cellular mechanisms which contribute to the development of stress tolerance upon a prolonged (0–12 h) fever-like (40 °C) or a moderate (42.5 °C) hyperthermia in mammalian Chinese Hamster Ovary (CHO) cells. Our results indicate that mild heat triggers a distinct, dose-dependent remodeling of the cellular lipidome followed by the expression of heat shock proteins only at higher heat dosages. A significant elevation in the relative concentration of saturate

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Hanikoglu, Aysegul, Ertan Kucuksayan, Ferhat Hanikoglu, et al. "Effects of Somatostatin and Vitamin C on the Fatty Acid Profile of Breast Cancer Cell Membranes." Anti-Cancer Agents in Medicinal Chemistry 19, no. 15 (2019): 1899–909. http://dx.doi.org/10.2174/1871520619666190930130732.

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Background: Vitamin C (Vit C) is an important physiological antioxidant with growing applications in cancer. Somatostatin (SST) is a natural peptide with growth inhibitory effect in several mammary cancer models. Objective: The combined effects of SST and Vit C supplementation have never been studied in breast cancer cells so far. Methods: We used MCF-7 and MDA-MB231 breast cancer cells incubated with SST for 24h, in the absence and presence of Vit C, at their EC50 concentrations, to evaluate membrane fatty acid-profiles together with the follow-up of EGFR and MAPK signaling pathways. Results:

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van der Wel, Nicole N., Masahiko Sugita, Donna M. Fluitsma, et al. "CD1 and Major Histocompatibility Complex II Molecules Follow a Different Course during Dendritic Cell Maturation." Molecular Biology of the Cell 14, no. 8 (2003): 3378–88. http://dx.doi.org/10.1091/mbc.e02-11-0744.

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The maturation of dendritic cells is accompanied by the redistribution of major histocompatibility complex (MHC) class II molecules from the lysosomal MHC class II compartment to the plasma membrane to mediate presentation of peptide antigens. Besides MHC molecules, dendritic cells also express CD1 molecules that mediate presentation of lipid antigens. Herein, we show that in human monocyte-derived dendritic cells, unlike MHC class II, the steady-state distribution of lysosomal CD1b and CD1c isoforms was unperturbed in response to lipopolysaccharide-induced maturation. However, the lysosomes i

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McDermott, Mark, Michael J. O. Wakelam, and Andrew J. Morris. "Phospholipase D." Biochemistry and Cell Biology 82, no. 1 (2004): 225–53. http://dx.doi.org/10.1139/o03-079.

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Phospholipase D catalyses the hydrolysis of the phosphodiester bond of glycerophospholipids to generate phosphatidic acid and a free headgroup. Phospholipase D activities have been detected in simple to complex organisms from viruses and bacteria to yeast, plants, and mammals. Although enzymes with broader selectivity are found in some of the lower organisms, the plant, yeast, and mammalian enzymes are selective for phosphatidylcholine. The two mammalian phospholipase D isoforms are regulated by protein kinases and GTP binding proteins of the ADP-ribosylation and Rho families. Mammalian and ye

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Chen, Yong, Jie Qin, Jiye Cai, and Zheng W. Chen. "Cold Induces Micro- and Nano-Scale Reorganization of Lipid Raft Markers at Mounds of T-Cell Membrane Fluctuations." PLoS ONE 4, no. 4 (2009): e5386. http://dx.doi.org/10.1371/journal.pone.0005386.

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Seveau, Stéphanie, Robert J. Eddy, Frederick R. Maxfield, and Lynda M. Pierini. "Cytoskeleton-dependent Membrane Domain Segregation during Neutrophil Polarization." Molecular Biology of the Cell 12, no. 11 (2001): 3550–62. http://dx.doi.org/10.1091/mbc.12.11.3550.

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On treatment with chemoattractant, the neutrophil plasma membrane becomes organized into detergent-resistant membrane domains (DRMs), the distribution of which is intimately correlated with cell polarization. Plasma membrane at the front of polarized cells is susceptible to extraction by cold Triton X-100, whereas membrane at the rear is resistant to extraction. After cold Triton X-100 extraction, DRM components, including the transmembrane proteins CD44 and CD43, the GPI-linked CD16, and the lipid analog, DiIC16, are retained within uropods and cell bodies. Furthermore, CD44 and CD43 interact

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Price, Harry, and Ron Wallace. "Field-induced reorganization of the neural membrane lipid bilayer: a proposed role in the regulation of ion-channel dynamics." Biosystems 68, no. 1 (2003): 67–77. http://dx.doi.org/10.1016/s0303-2647(02)00158-2.

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Offenhäuser, Nina, Alessandro Borgonovo, Andrea Disanza, et al. "The eps8 Family of Proteins Links Growth Factor Stimulation to Actin Reorganization Generating Functional Redundancy in the Ras/Rac Pathway." Molecular Biology of the Cell 15, no. 1 (2004): 91–98. http://dx.doi.org/10.1091/mbc.e03-06-0427.

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Sos-1, a guanine nucleotide exchange factor (GEF), eps8 and Abi1, two signaling proteins, and the lipid kinase phosphoinositide 3-kinase (PI3-K), assemble in a multimolecular complex required for Rac activation leading to actin cytoskeletal remodeling. Consistently, eps8 –/– fibroblasts fail to form membrane ruffles in response to growth factor stimulation. Surprisingly, eps8 null mice are healthy, fertile, and display no overt phenotype, suggesting the existence of functional redundancy within this pathway. Here, we describe the identification and characterization of a family of eps8-related

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Bura, Ana, and Antonija Jurak Begonja. "Imaging of Intracellular and Plasma Membrane Pools of PI(4,5)P2 and PI4P in Human Platelets." Life 11, no. 12 (2021): 1331. http://dx.doi.org/10.3390/life11121331.

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Phosphoinositides (PIs) are phosphorylated membrane lipids that have a plethora of roles in the cell, including vesicle trafficking, signaling, and actin reorganization. The most abundant PIs in the cell are phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2] and phosphatidylinositol-4-monophosphate (PI4P). The localization and roles of both PI(4,5)P2 and PI4P are well established, is the broadly accepted methodological approach for their immunocytochemical visualization in different cell compartments in several cell lines. However, not much is known about these PIs in platelets (PLTs), the smal

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Seo, Pil Joon, Mi Jung Kim, Jin-Su Song, Youn-Sung Kim, Hie-Joon Kim, and Chung-Mo Park. "Proteolytic processing of an Arabidopsis membrane-bound NAC transcription factor is triggered by cold-induced changes in membrane fluidity." Biochemical Journal 427, no. 3 (2010): 359–67. http://dx.doi.org/10.1042/bj20091762.

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Changes in membrane fluidity are the earliest cellular events that occur in plant cells upon exposure to cold. This subsequently triggers physiological processes, such as calcium influx and reorganization of actin cytoskeletons, and induces expression of cold-responsive genes. The plasma-membrane-anchored NAC (NAM/ATAF/CUC) transcription factor NTL6 is of particular interest. Cold triggers proteolytic activation of the dormant NTL6 protein, which in turn elicits pathogen-resistance responses by inducing a small group of cold-inducible PR (pathogenesis-related) genes in Arabidopsis. In the pres

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Czuczman, Myron S., Scott Olejniczak, Aruna C. Gowda, Petr Starostik, and Francisco J. Hernandez-Ilizaliturri. "Acquirement of Rituximab Resistance in Lymphoma Cell Lines Is Associated with Structural Changes in the Internal Domain of CD20 Regulated at the Post-Transcriptional Level." Blood 104, no. 11 (2004): 2280. http://dx.doi.org/10.1182/blood.v104.11.2280.2280.

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Abstract The acquirement of resistance to rituximab has been observed in lymphoma patients. To further define the molecular basis for rituximab-resistance we have developed various rituximab-resistant cell lines (RRCL) and studied changes in CD20 structure at the protein and gene level, membrane reorganization, and signaling events following rituximab exposure. RRCL were generated by chronic exposure of Raji cells to escalating doses of rituximab alone (2R) or concurrently with human complement (4RH). Functional assays were performed to demonstrate decrease in rituximab-associated CMC and ADCC

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Tomassian, Tamar Kathy, Scot Daren Liu, and M. Carrie Miceli. "Caveolin-1 expression in CD8 T cells positively regulates CD8 T cell function and burst size (83.15)." Journal of Immunology 182, no. 1_Supplement (2009): 83.15. http://dx.doi.org/10.4049/jimmunol.182.supp.83.15.

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Abstract Caveolin-1 (Cav-1) is a molecular scaffold involved in lipid raft organization as well as protein and membrane trafficking, cytoskeletal reorganization, and regulation of signal transduction in several cell types. Despite initial reports suggesting that cav-1 is not present in lymphocytes, we have identified cav-1 expression in murine T cells by immunoblotting lysates from purified primary T cell populations. We also show that cav-1 positively regulates TCR/CD28 induced CD8 T cell activation. CD8 T cells from cav-1 knockout (KO) mice hypoproliferate and undergo 2 to 3-fold fewer cell

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Qian, Shuo, and William T. Heller. "Melittin-induced cholesterol reorganization in lipid bilayer membranes." Biochimica et Biophysica Acta (BBA) - Biomembranes 1848, no. 10 (2015): 2253–60. http://dx.doi.org/10.1016/j.bbamem.2015.06.012.

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Kadri, Samia, Kumiko Nakada-Tsukui, Natsuki Watanabe, Ghulam Jeelani, and Tomoyoshi Nozaki. "PTEN differentially regulates endocytosis, migration, and proliferation in the enteric protozoan parasite Entamoeba histolytica." PLOS Pathogens 18, no. 5 (2022): e1010147. http://dx.doi.org/10.1371/journal.ppat.1010147.

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PTEN is a lipid phosphatase that is highly conserved and involved in a broad range of biological processes including cytoskeletal reorganization, endocytosis, signal transduction, and cell migration in all eukaryotes. Although regulation of phosphatidylinositol (3,4,5)-trisphosphate [PtdIns(3,4,5)P3] signaling via PTEN has been well established in model organisms and mammals, it remains elusive in the parasitic protist E. histolytica, which heavily relies on PtdIns phosphate(s)-dependent membrane traffic, migration, and phago- and trogocytosis for its pathogenesis. In this study, we characteri

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Hernandez-Ilizaliturri, Francisco J., Scott H. Olejniczak, Joy Knight, and Myron S. Czuczman. "Structural Changes in the Internal Domain of CD20 Antigen Associated with the Emergence of Rituximab Resistance: Effects of Proteasome Inhibition in CD20 Structure and Rituximab Anti-Tumor Activity in Rituximab-Resistant Cell Lines (RRCL)." Blood 106, no. 11 (2005): 1474. http://dx.doi.org/10.1182/blood.v106.11.1474.1474.

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Abstract Background: The acquirement of resistance to rituximab has been observed in lymphoma patients. To define the molecular basis for rituximab resistance we developed various RRCL and studied changes in CD20 structure, membrane reorganization and signaling events following rituximab therapy in RRCL. In addition we previously reported upregulation in gene/protein expression of members of the ubiquitin-proteasome system in RRCL. Recently, we evaluated the effects of proteasome inhibition in the structure of CD20 antigen and rituximab sensitivity in RRCL. Methods: RRCL were generated by chro

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Pack, Daniel W., Kingman Ng, Kevin M. Maloney, and Frances H. Arnold. "Ligand-induced reorganization and assembly in synthetic lipid membranes." Supramolecular Science 4, no. 1-2 (1997): 3–10. http://dx.doi.org/10.1016/s0968-5677(96)00045-4.

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Hu, Shipeng, Tao Zhao, Hewen Li, Danling Cheng, and Zhihua Sun. "Effect of tetracaine on dynamic reorganization of lipid membranes." Biochimica et Biophysica Acta (BBA) - Biomembranes 1862, no. 9 (2020): 183351. http://dx.doi.org/10.1016/j.bbamem.2020.183351.

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Cheng, Danling, Hewen Li, Shipeng Hu, and Tao Zhao. "Structural effects of zinc on phosphatidylserine-containing lipid membranes: kinetic analysis of membrane reorganization." New Journal of Chemistry 46, no. 16 (2022): 7748–57. http://dx.doi.org/10.1039/d2nj00515h.

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Windschiegl, Barbara, Alexander Orth, Winfried Römer, et al. "Lipid Reorganization Induced by Shiga Toxin Clustering on Planar Membranes." PLoS ONE 4, no. 7 (2009): e6238. http://dx.doi.org/10.1371/journal.pone.0006238.

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