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Journal articles on the topic 'Lipid-related disorders'

Author: Grafiati

Published: 8 June 2024

Last updated: 31 July 2025

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1

Wu, Xunzhi, Zhen Chen, Yue Wu, et al. "Flazin as a Lipid Droplet Regulator against Lipid Disorders." Nutrients 14, no. 7 (2022): 1501. http://dx.doi.org/10.3390/nu14071501.

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Lipid disorders are closely related to numerous metabolic diseases, and lipid droplets (LDs) have been considered as a new target for regulating lipid metabolism. Dietary intervention and nutraceuticals provide safe and long-term beneficial effects for treating metabolic diseases. Flazin is a diet-derived bioactive constituent mainly existing in fermented foods, of which the lipid metabolism improvement function has not been studied. In this study, the effect of flazin on lipid regulation at both cell level and organelle level was investigated. Lipidomic profiling showed that flazin significan

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Kleme, Marie-Laure, and Emile Levy. "Cystic Fibrosis-Related Oxidative Stress and Intestinal Lipid Disorders." Antioxidants & Redox Signaling 22, no. 7 (2015): 614–31. http://dx.doi.org/10.1089/ars.2014.6012.

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Beaufrère, Hugues, Drury Reavill, Jill Heatley, and Leonardo Susta. "Lipid-Related Lesions in Quaker Parrots (Myiopsitta monachus)." Veterinary Pathology 56, no. 2 (2018): 282–88. http://dx.doi.org/10.1177/0300985818800025.

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The Quaker parrot has been used as a psittacine model to study clinical lipidology and lipid-related disorders. However, while Quaker parrots appear to be anecdotally susceptible to a variety of spontaneous dyslipidemic disorders and lesions caused by excess lipid accumulation, epidemiologic data are lacking. A multicenter retrospective study on 652 pathology submissions (411 necropsies and 243 biopsies) from Quaker parrots was performed by recording the final pathological diagnoses, age, and sex for each bird. The prevalence of lesions associated with lipid metabolism, such as hepatic lipidos

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Latruffe, Norbert. "Insights on recent advances in lipid metabolism and related disorders." Biochimie 86, no. 11 (2004): 741–42. http://dx.doi.org/10.1016/j.biochi.2004.10.001.

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Grummer, Ric R. "Etiology of Lipid-Related Metabolic Disorders in Periparturient Dairy Cows." Journal of Dairy Science 76, no. 12 (1993): 3882–96. http://dx.doi.org/10.3168/jds.s0022-0302(93)77729-2.

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6

Belamarich, Peter F. "Lipoprotein Disorders." Pediatrics In Review 17, no. 4 (1996): 144. http://dx.doi.org/10.1542/pir.17.4.144.

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Although symptomatic lipoproteinemias are rare in childhood, early detection often can prevent severe complications. Abetalipoproteinemia is characterized by severe hypolipidemia, fat malabsorption, failure to thrive, unusual spiculated erythrocytes known as acanthocytes, and progressive neuromuscular and retinal pigmentary degeneration believed to be related to vitamin E deficiency. Plasma triglyceride concentrations are so low as to be frequently undetectable, and cholesterol concentrations typically are less than 50% of normal. This disorder results from an inability of both enterocytes and

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Bingöl, Züleyha, Hacer Durmuş Tekce, Gülseren Sağcan, Piraye Serdaroğlu, and Esen Kıyan. "Pulmonary functions and sleep-related breathing disorders in lipid storage disease." Sleep and Breathing 22, no. 4 (2018): 1137–42. http://dx.doi.org/10.1007/s11325-018-1647-1.

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Novacky, Anton. "LIPID PEROXIDATION AND PLANT TISSUE DISORDERS." HortScience 28, no. 5 (1993): 470f—471. http://dx.doi.org/10.21273/hortsci.28.5.470f.

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Increased solute leakage resulting from ozone injury, senescence, wounding and virus or bacteria-induced hypersensitive reaction [HR] have been related to membrane lipid peroxidation [LPX]. The genesis of LPX in various situations may derive from several different processes: a) the direct addition of O2 to unsaturated fatty acids forming hydroperoxide in an enzymatic reaction catalyzed by lipoxygenase, an enzyme widely distributed in plant seed, root, and leaf tissue or b) peroxidation by active oxygen species [AO], e.g. O2 and H2O2, that are generated during normal cellular metabolic activiti

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Cao, Shixi, Mengqi Liu, Yao Han, et al. "Effects of Saponins on Lipid Metabolism: The Gut–Liver Axis Plays a Key Role." Nutrients 16, no. 10 (2024): 1514. http://dx.doi.org/10.3390/nu16101514.

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Unhealthy lifestyles (high-fat diet, smoking, alcohol consumption, too little exercise, etc.) in the current society are prone to cause lipid metabolism disorders affecting the health of the organism and inducing the occurrence of diseases. Saponins, as biologically active substances present in plants, have lipid-lowering, inflammation-reducing, and anti-atherosclerotic effects. Saponins are thought to be involved in the regulation of lipid metabolism in the body; it suppresses the appetite and, thus, reduces energy intake by modulating pro-opiomelanocortin/Cocaine amphetamine regulated transc

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Liang, Yaxu, Jun Qi, Dongming Yu, et al. "Ferulic Acid Alleviates Lipid and Bile Acid Metabolism Disorders by Targeting FASN and CYP7A1 in Iron Overload-Treated Mice." Antioxidants 13, no. 11 (2024): 1277. http://dx.doi.org/10.3390/antiox13111277.

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Iron overload is a common complication in various chronic liver diseases, including non-alcoholic fatty liver disease (NAFLD). Lipid and bile acid metabolism disorders are regarded as crucial hallmarks of NAFLD. However, effects of iron accumulation on lipid and bile acid metabolism are not well understood. Ferulic acid (FA) can chelate iron and regulate lipid and bile acid metabolism, but its potential to alleviate lipid and bile acid metabolism disorders caused by iron overload remains unclear. Here, in vitro experiments, iron overload induced oxidative stress, apoptosis, genomic instability

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Zhao, Aili, Yiqin Chen, Yixin Li, et al. "Sulfated Polysaccharides from Enteromorpha prolifera Attenuate Lipid Metabolism Disorders in Mice with Obesity Induced by a High-Fat Diet via a Pathway Dependent on AMP-Activated Protein Kinase." Journal of Nutrition 152, no. 4 (2021): 939–49. http://dx.doi.org/10.1093/jn/nxab432.

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ABSTRACT Background Obesity-related metabolic diseases have recently evoked worldwide attention. Studies have demonstrated that Enteromorpha polysaccharide (EP) exerts lipid-lowering effects, but the underlying mechanism remains unclear. Objectives We investigated whether EP regulates lipid metabolism disorders in mice with high-fat diet (HFD)–induced obesity via an AMP-activated protein kinase (AMPK)–dependent pathway. Methods Six-week-old male C57BL/6J mice (18 ± 2 g) were fed a normal diet (ND; 10% energy from fats) or an HFD (60% energy from fats) for 6 weeks to induce obesity and treated

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12

Barrera, Giuseppina, Stefania Pizzimenti, Martina Daga, et al. "Lipid Peroxidation-Derived Aldehydes, 4-Hydroxynonenal and Malondialdehyde in Aging-Related Disorders." Antioxidants 7, no. 8 (2018): 102. http://dx.doi.org/10.3390/antiox7080102.

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Among the various mechanisms involved in aging, it was proposed long ago that a prominent role is played by oxidative stress. A major way by which the latter can provoke structural damage to biological macromolecules, such as DNA, lipids, and proteins, is by fueling the peroxidation of membrane lipids, leading to the production of several reactive aldehydes. Lipid peroxidation-derived aldehydes can not only modify biological macromolecules, by forming covalent electrophilic addition products with them, but also act as second messengers of oxidative stress, having relatively extended lifespans.

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Stanković, Veroslava, Dragana Jović, Simonida Mitić, Sava Mitić, and Andrijana Zuber. "The impact of myo inositol on glycoregulation and lipid profile." Education and Research in Health Sciences 3, no. 1-2 (2024): 15–20. https://doi.org/10.5937/erhs3-56419.

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Myo-inositol has attracted attention due to its potential as a therapeutic agent in the treatment of metabolic disorders, particularly diabetes mellitus (DM) and lipid profile disorders. This study investigates the role of myo-inositol in the regulation of glucose metabolism, insulin sensitivity, and lipid profile, with a special focus on its impact on type 2 diabetes and associated lipid disorders. Myo-inositol plays a key role in insulin signaling by regulating insulin action in target tissues, enhancing glucose uptake, and reducing insulin resistance. Clinical studies show that myo-inositol

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Zhang, Weiyun, Chi-Tang Ho, and Muwen Lu. "Piperine Improves Lipid Dysregulation by Modulating Circadian Genes Bmal1 and Clock in HepG2 Cells." International Journal of Molecular Sciences 23, no. 10 (2022): 5611. http://dx.doi.org/10.3390/ijms23105611.

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Metabolic disorders are closely associated with the dysregulation of circadian rhythms. Many bioactive components with lipid metabolism-regulating effects have been reported to function through circadian clock-related mechanisms. As the main pungent principle of black pepper, piperine (PIP) has been demonstrated to possess anti-obesity bioactivity by affecting hepatic lipid metabolism-related factors. However, whether the circadian clock genes Bmal1 and Clock are involved in the protective effect of PIP against lipid metabolism disorders remains unknown. In this work, oleic acid (OA) induced l

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Ilderbayev, Oralbek Z., Sergey V. Kashanskiy, Laura Ye Chulenbayeva, Masygut R. Mynzhanov, and Gulzhan O. Ilderbayeva. "Disorders of immune state parameters and lipid peroxidation under experimental exposure to radiation." Occupational Health and Industrial Ecology, no. 11 (February 18, 2019): 16–21. http://dx.doi.org/10.31089/1026-9428-2018-11-16-21.

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The article presents experimental data on the impact of high dose gamma-radiation exposure (6 Gy) on immune system, lipid oxidation products (LOPs) and antioxidant defense system (AODS) enzymes activity. The study revealed that high dose radiation exposure suppressed the cell-mediated immunity especially with respect to T-lymphocytes and their subpopulations as well as immune defense and adaptation mechanisms. Ionizing radiation exposure led to increase of conjugated lipid dienes and malondialdehyde (MDA), and to inhibition of catalase and glutathione peroxidise activity, thus promoting oxidat

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Han, Wen, Shuxian Yang, Haiyan Xiao, et al. "Role of Adiponectin in Cardiovascular Diseases Related to Glucose and Lipid Metabolism Disorders." International Journal of Molecular Sciences 23, no. 24 (2022): 15627. http://dx.doi.org/10.3390/ijms232415627.

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Lifestyle changes have led to increased incidence of cardiovascular disease (CVD); therefore, potential targets against CVD should be explored to mitigate its risks. Adiponectin (APN), an adipokine secreted by adipose tissue, has numerous beneficial effects against CVD related to glucose and lipid metabolism disorders, including regulation of glucose and lipid metabolism, increasing insulin sensitivity, reduction of oxidative stress and inflammation, protection of myocardial cells, and improvement in endothelial cell function. These effects demonstrate the anti-atherosclerotic and antihyperten

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Hu, Ping, Kaiqi Li, Xiaoxu Peng та ін. "Nuclear Receptor PPARα as a Therapeutic Target in Diseases Associated with Lipid Metabolism Disorders". Nutrients 15, № 22 (2023): 4772. http://dx.doi.org/10.3390/nu15224772.

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Lipid metabolic diseases have substantial morbidity and mortality rates, posing a significant threat to human health. PPARα, a member of the peroxisome proliferator-activated receptors (PPARs), plays a crucial role in lipid metabolism and immune regulation. Recent studies have increasingly recognized the pivotal involvement of PPARα in diverse pathological conditions. This comprehensive review aims to elucidate the multifaceted role of PPARα in metabolic diseases including liver diseases, diabetes-related diseases, age-related diseases, and cancers, shedding light on the underlying molecular m

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Humer, Elke, Christoph Pieh, and Georg Brandmayr. "Metabolomics in Sleep, Insomnia and Sleep Apnea." International Journal of Molecular Sciences 21, no. 19 (2020): 7244. http://dx.doi.org/10.3390/ijms21197244.

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Sleep-wake disorders are highly prevalent disorders, which can lead to negative effects on cognitive, emotional and interpersonal functioning, and can cause maladaptive metabolic changes. Recent studies support the notion that metabolic processes correlate with sleep. The study of metabolite biomarkers (metabolomics) in a large-scale manner offers unique opportunities to provide insights into the pathology of diseases by revealing alterations in metabolic pathways. This review aims to summarize the status of metabolomic analyses-based knowledge on sleep disorders and to present knowledge in un

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Xu, Wenchao, Yuting Zhu, Siyuan Wang, Jihong Liu, and Hao Li. "From Adipose to Ailing Kidneys: The Role of Lipid Metabolism in Obesity-Related Chronic Kidney Disease." Antioxidants 13, no. 12 (2024): 1540. https://doi.org/10.3390/antiox13121540.

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Obesity has emerged as a significant public health crisis, closely linked to the pathogenesis and progression of chronic kidney disease (CKD). This review explores the intricate relationship between obesity-induced lipid metabolism disorders and renal health. We discuss how excessive free fatty acids (FFAs) lead to lipid accumulation in renal tissues, resulting in cellular lipotoxicity, oxidative stress, and inflammation, ultimately contributing to renal injury. Key molecular mechanisms, including the roles of transcriptional regulators like PPARs and SREBP-1, are examined for their implicatio

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Wan, Juan, Meiyan Feng, Wenjing Pan, et al. "Inhibitory Effects of Six Types of Tea on Aging and High-Fat Diet-Related Amyloid Formation Activities." Antioxidants 10, no. 10 (2021): 1513. http://dx.doi.org/10.3390/antiox10101513.

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Aging and lipid metabolism disorders promote the formation and accumulation of amyloid with β-sheet structure, closely related to cardiovascular disease, senile dementia, type 2 diabetes, and other senile degenerative diseases. In this study, five representative teas were selected from each of the six types of tea, and a total of 30 teas were selected to evaluate the inhibitory activities on the formation of aging-related amyloid in vitro. The results showed that the 30 teas had a significant inhibitory effect on the formation activity on aging-related amyloid at the protein level in vitro. Al

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Wang, Jiayi, Jinzhong Jing, Zhengyi Gong, et al. "Different Dietary Sources of Selenium Alleviate Hepatic Lipid Metabolism Disorder of Heat-Stressed Broilers by Relieving Endoplasmic Reticulum Stress." International Journal of Molecular Sciences 24, no. 20 (2023): 15443. http://dx.doi.org/10.3390/ijms242015443.

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As global warming continues, the phenomenon of heat stress (HS) in broilers occurs frequently. The alleviating effect of different selenium (Se) sources on HS-induced hepatic lipid metabolism disorders in broilers remains unclear. This study compared the protective effects of four Se sources (sodium selenite; selenium yeast; selenomethionine; nano-Se) on HS-induced hepatic lipid metabolism disorder and the corresponding response of selenotranscriptome in the liver of broilers. The results showed that HS-induced liver injury and hepatic lipid metabolism disorder, which were reflected in the inc

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Ferrer, María José, Aimé Florencia Silva, Giselle Adriana Abruzzese, Mariela Edith Velázquez, and Alicia Beatriz Motta. "Lipid Metabolism and Relevant Disorders to Female Reproductive Health." Current Medicinal Chemistry 28, no. 27 (2021): 5625–47. http://dx.doi.org/10.2174/0929867328666210106142912.

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Background: Lipids are essential components of cells that participate in metabolic and endocrine regulation and reproductive functions. The main organs where lipid regulation takes place are the liver and adipose tissue. Besides, when each tissue- specific action cannot be exerted, it could lead to several endocrine-metabolic disorders closely related to PCOS, such as non-alcoholic fatty liver disease (NAFLD) and obesity. Objective: This work aims to discuss the impact of lipid alterations on metabolic and reproductive health. Therefore, this review focus on the importance of carrying out an i

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Gan, Linli, Hongrui Guo, Qiyuan Yang та ін. "Alkaline Mineral Complex Water Attenuates Transportation-Induced Hepatic Lipid Metabolism Dysregulation by AMPKα-SREBP-1c/PPARα Pathways". International Journal of Molecular Sciences 25, № 21 (2024): 11373. http://dx.doi.org/10.3390/ijms252111373.

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Transportation, an unavoidable process in livestock farming, causes metabolic disorders in the body, which then lead to endocrine disruption, being immunocompromised, and growth suppression. Lipid metabolism dysregulation is a critical phenotype induced by transportation. The liver is a vital organ in lipid metabolism, with a role in both lipid synthesis and lipolysis. However, the specific mechanisms by which transportation affects hepatic lipid metabolism remain unclear. This study employed rats as a model to investigate the effects of transportation on hepatic lipid metabolism. Rats subject

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Park, Jeong Yong, Mi Gyeong Jang, Jung Min Oh, et al. "Sasa quelpaertensis Leaf Extract Ameliorates Dyslipidemia, Insulin Resistance, and Hepatic Lipid Accumulation in High-Fructose-Diet-Fed Rats." Nutrients 12, no. 12 (2020): 3762. http://dx.doi.org/10.3390/nu12123762.

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Background: Increased dietary fructose consumption is closely associated with lipid and glucose metabolic disorders. Sasa quelpaertensis Nakai possesses various health-promoting properties, but there has been no research on its protective effect against fructose-induced metabolic dysfunction. In this study, we investigated the effects of S. quelpaertensis leaf extract (SQE) on metabolic dysfunction in high-fructose-diet-fed rats. Methods: Animals were fed a 46% carbohydrate diet, a 60% high-fructose diet, or a 60% high-fructose diet with SQE (500 mg/kg of body weight (BW)/day) in drinking wate

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Peikert, Kevin, and Adrian Danek. "VPS13 Forum Proceedings: XK, XK-Related and VPS13 Proteins in Membrane Lipid Dynamics." Contact 6 (January 2023): 251525642311569. http://dx.doi.org/10.1177/25152564231156994.

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In 2020, the pandemic interrupted the series of biannual International Neuroacanthocytosis Meetings that brought together clinicians, scientists, and patient groups to share research into a small group of devastating genetic diseases that combine both acanthocytosis (deformed red blood cells) and neurodegeneration with movement disorders. This Meeting Report describes talks at the 5th VPS13 Forum in January 2022, one of a series of online meetings held to fill the gap. The meeting addressed the basic biology of two key proteins implicated in chorea-acanthocytosis (mutations in VPS13A) and McLe

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Găman, Mihnea-Alexandru, Elena-Codruța Dobrică, Matei-Alexandru Cozma, et al. "Crosstalk of Magnesium and Serum Lipids in Dyslipidemia and Associated Disorders: A Systematic Review." Nutrients 13, no. 5 (2021): 1411. http://dx.doi.org/10.3390/nu13051411.

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Dyslipidemia is a significant threat to public health worldwide and the identification of its pathogenic mechanisms, as well as novel lipid-lowering agents, are warranted. Magnesium (Mg) is a key element to human health and its deficiency has been linked to the development of lipid abnormalities and related disorders, such as the metabolic syndrome, type 2 diabetes mellitus, or cardiovascular disease. In this review, we explored the associations of Mg (dietary intake, Mg concentrations in the body) and the lipid profile, as well as the impact of Mg supplementation on serum lipids. A systematic

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Zhuang, Zhong, Wenqian Jia, Lei Wu, et al. "Threonine Deficiency Increases Triglyceride Deposition in Primary Duck Hepatocytes by Reducing STAT3 Phosphorylation." International Journal of Molecular Sciences 25, no. 15 (2024): 8142. http://dx.doi.org/10.3390/ijms25158142.

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Liver lipid metabolism disruption significantly contributes to excessive fat buildup in waterfowl. Research suggests that the supplementation of Threonine (Thr) in the diet can improve liver lipid metabolism disorder, while Thr deficiency can lead to such metabolic disorders in the liver. The mechanisms through which Thr regulates lipid metabolism remain unclear. STAT3 (signal transducer and activator of transcription 3), a crucial transcription factor in the JAK-STAT (Janus kinase–signal transducer and activator of transcription) pathway, participates in various biological processes, includin

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Liu, Yishi, Zehui Yang, Xiaoman Zhou, Zijie Li, and Nakanishi Hideki. "Diacylglycerol Kinases and Its Role in Lipid Metabolism and Related Diseases." International Journal of Molecular Sciences 25, no. 23 (2024): 13207. https://doi.org/10.3390/ijms252313207.

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Lipids are essential components of eukaryotic membranes, playing crucial roles in membrane structure, energy storage, and signaling. They are predominantly synthesized in the endoplasmic reticulum (ER) and subsequently transported to other organelles. Diacylglycerol kinases (DGKs) are a conserved enzyme family that phosphorylate diacylglycerol (DAG) to produce phosphatidic acid (PA), both of which are key intermediates in lipid metabolism and second messengers involved in numerous cellular processes. Dysregulation of DGK activity is associated with several diseases, including cancer and metabo

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Di, Sha, Yitian Wang, Lin Han, et al. "The Intervention Effect of Traditional Chinese Medicine on the Intestinal Flora and Its Metabolites in Glycolipid Metabolic Disorders." Evidence-Based Complementary and Alternative Medicine 2019 (June 4, 2019): 1–13. http://dx.doi.org/10.1155/2019/2958920.

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Metabolic syndrome (MS), which includes metabolic disorders such as protein disorder, glucose disorder, lipid disorder, and carbohydrate disorder, has been growing rapidly around the world. Glycolipid disorders are a main type of metabolic syndrome and are characterized by abdominal obesity and abnormal metabolic disorders of lipid, glucose, and carbohydrate utilization, which can cause cardiovascular and cerebrovascular diseases. Glycolipid disorders are closely related to intestinal flora and its metabolites. However, studies about the biological mechanisms of the intestinal flora and its me

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Elgretli, Wesal, Tianyan Chen, Nadine Kronfli, and Giada Sebastiani. "Hepatitis C Virus-Lipid Interplay: Pathogenesis and Clinical Impact." Biomedicines 11, no. 2 (2023): 271. http://dx.doi.org/10.3390/biomedicines11020271.

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Hepatitis C virus (HCV) infection represents the major cause of chronic liver disease, leading to a wide range of hepatic diseases, including cirrhosis and hepatocellular carcinoma. It is the leading indication for liver transplantation worldwide. In addition, there is a growing body of evidence concerning the role of HCV in extrahepatic manifestations, including immune-related disorders and metabolic abnormalities, such as insulin resistance and steatosis. HCV depends on its host cells to propagate successfully, and every aspect of the HCV life cycle is closely related to human lipid metaboli

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Ashraf, Ambika P., Brenda Kohn, and Don P. Wilson. "Improving Long-Term Outcomes of Youth With Lipid Abnormalities—Expanding the Role of Pediatric Endocrinologists." Journal of Clinical Endocrinology & Metabolism 104, no. 10 (2019): 4421–26. http://dx.doi.org/10.1210/jc.2019-00150.

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Abstract Context There is a disturbingly high prevalence of dyslipidemia in youth. Although pediatric endocrinologists are aware of the substantial cardiovascular (CV) risk associated with monogenic disorders of lipid and lipoprotein metabolism, relatively few recognize the CV disease (CVD)-related morbidity and premature mortality incurred by common endocrine disorders associated with dyslipidemia, such as diabetes mellitus, growth hormone deficiency, congenital adrenal hyperplasia, and hypopituitarism. Objective In this article, we discuss the expanding role of pediatric endocrinologists in

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Fotschki, Bartosz, Jerzy Juśkiewicz, Adam Jurgoński, and Michał Sójka. "Fructo-Oligosaccharides and Pectins Enhance Beneficial Effects of Raspberry Polyphenols in Rats with Nonalcoholic Fatty Liver." Nutrients 13, no. 3 (2021): 833. http://dx.doi.org/10.3390/nu13030833.

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In recent years, nonalcoholic fatty liver disorders have become one of the most common liver pathologies; therefore, it is necessary to investigate the dietary compounds that may support the regulation of liver metabolism and related inflammatory processes. The present study examines the effect of raspberry polyphenolic extract (RE) combined with fructo-oligosaccharides (FOSs) or pectins (PECs) on caecal microbial fermentation, liver lipid metabolism and inflammation in rats with fatty liver induced by an obesogenic diet. The combination of RE with FOSs or PECs reduced the production of short-

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Rakheja, Dinesh, and Richard L. Boriack. "Precholesterol Sterols Accumulate in Lipid Rafts of Patients with Smith-Lemli-Opitz Syndrome and X-Linked Dominant Chondrodysplasia Punctata." Pediatric and Developmental Pathology 11, no. 2 (2008): 128–32. http://dx.doi.org/10.2350/06-10-0179.1.

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Systemic fetal dysmorphogenesis in disorders of postsqualene cholesterol biosynthesis is thought to be caused by disruption of Hedgehog signaling. Because precholesterol sterols such as 7-dehydrocholesterol and lathosterol can replace cholesterol in the activation of Hedgehog proteins, it is currently believed that cholesterol deficiency-related Hedgehog signaling block occurs further downstream, probably at the level of Smoothened. Experimentally, such a block in Hedgehog signaling occurs at sterol levels of <40 μg/mg protein. Recently, we studied autopsy material from 2 infants with fatal

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Stefanov, Stefan R., and Velichka Y. Andonova. "Lipid Nanoparticulate Drug Delivery Systems: Recent Advances in the Treatment of Skin Disorders." Pharmaceuticals 14, no. 11 (2021): 1083. http://dx.doi.org/10.3390/ph14111083.

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The multifunctional role of the human skin is well known. It acts as a sensory and immune organ that protects the human body from harmful environmental impacts such as chemical, mechanical, and physical threats, reduces UV radiation effects, prevents moisture loss, and helps thermoregulation. In this regard, skin disorders related to skin integrity require adequate treatment. Lipid nanoparticles (LN) are recognized as promising drug delivery systems (DDS) in treating skin disorders. Solid lipid nanoparticles (SLN) together with nanostructured lipid carriers (NLC) exhibit excellent tolerability

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Abdo, Abdullah Abdulaziz Abbod, Chengnan Zhang, Prasanna Patil, Chao Teng, Xiuting Li, and Xin Liang. "Biological functions of nutraceutical xylan oligosaccharides as a natural solution for modulation of obesity, diabetes, and related diseases." International Food Research Journal 29, no. 2 (2022): 236–47. http://dx.doi.org/10.47836/ifrj.29.2.02.

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Natural compounds have been used to regulate numerous metabolic dysfunctions such as obesity, diabetes, and dyslipidaemia. Xylan oligosaccharides (XOS) alleviate obesity, diabetes, and dyslipidaemia via the regulation of glucose and lipid metabolisms, and the modification of gut microbiota. Moreover, XOS is also shown to inhibit obesity, diabetes, and related metabolic disorders such as inflammation and oxidative stress, by regulating the related genes and enzymes that contribute to the respective disorders. The information currently available does not offer in-depth elucidation regarding the

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Saher, Gesine. "Cholesterol Metabolism in Aging and Age-Related Disorders." Annual Review of Neuroscience 46, no. 1 (2023): 59–78. http://dx.doi.org/10.1146/annurev-neuro-091922-034237.

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All mammalian cell membranes contain cholesterol to maintain membrane integrity. The transport of this hydrophobic lipid is mediated by lipoproteins. Cholesterol is especially enriched in the brain, particularly in synaptic and myelin membranes. Aging involves changes in sterol metabolism in peripheral organs and also in the brain. Some of those alterations have the potential to promote or to counteract the development of neurodegenerative diseases during aging. Here, we summarize the current knowledge of general principles of sterol metabolism in humans and mice, the most widely used model or

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Kibibi J., Wambui. "The Role of Epigenetics in Obesity-Driven Hyperlipidemia: Understanding Gene-Environment Interactions." IAA Journal of Scientific Research 11, no. 3 (2024): 27–31. http://dx.doi.org/10.59298/iaajsr/2024/113.2731.

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Obesity-driven hyperlipidemia, characterized by elevated levels of lipids in the blood, represents a significant risk factor for cardiovascular diseases. While genetic predisposition plays a role, epigenetic modifications have emerged as key mediators of the complex interactions between genes and environmental factors, including diet, physical activity, and lifestyle. Epigenetic mechanisms, such as DNA methylation, histone modifications, and non-coding RNAs, modulate gene expression without altering the underlying DNA sequence, influencing lipid metabolism and fat accumulation. This review exp

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Mesa-Herrera, Taoro-González, Valdés-Baizabal, Diaz, and Marín. "Lipid and Lipid Raft Alteration in Aging and Neurodegenerative Diseases: A Window for the Development of New Biomarkers." International Journal of Molecular Sciences 20, no. 15 (2019): 3810. http://dx.doi.org/10.3390/ijms20153810.

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Lipids in the brain are major components playing structural functions as well as physiological roles in nerve cells, such as neural communication, neurogenesis, synaptic transmission, signal transduction, membrane compartmentalization, and regulation of gene expression. Determination of brain lipid composition may provide not only essential information about normal brain functioning, but also about changes with aging and diseases. Indeed, deregulations of specific lipid classes and lipid homeostasis have been demonstrated in neurodegenerative disorders such as Alzheimer’s disease (AD) and Park

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Lee, Kyueun, Hyunju Kim, Casey M. Rebholz, and Jihye Kim. "Association between Different Types of Plant-Based Diets and Risk of Dyslipidemia: A Prospective Cohort Study." Nutrients 13, no. 1 (2021): 220. http://dx.doi.org/10.3390/nu13010220.

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We evaluated the associations among different types of plant-based diet indices, risk of dyslipidemia, and individual lipid disorders in Asian populations with different dietary patterns from Western populations. Participants included 4507 Korean adults aged ≥40 years without dyslipidemia and related chronic diseases at baseline (2001–2002). Dietary intakes were assessed using an average of validated food frequency questionnaires measured twice. We calculated three plant-based diet indices: overall plant-based diet index (PDI), healthful plant-based diet index (hPDI), and unhealthful plant-bas

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Povarova, O. V., E. A. Gorodetskaya, E. I. Kalenikova, and O. S. Medvedev. "Metabolic markers and oxidative stress in children’s obesity pathogenesis." Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics) 65, no. 1 (2020): 22–29. http://dx.doi.org/10.21508/1027-4065-2020-65-1-22-29.

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The article presents a modern view of obesity as a chronic inflammation of adipose tissue. Obesity is accompanied by metabolic changes in lipid, protein, carbohydrate, mineral metabolism and disorders in the hormonal function of adipose tissue as an endo- and paracrine organ. At the moment, there are searched the biochemical markers of metabolic disorders of obesity. The obesity-related factors (hyperglycemia, increased lipid levels, insulin resistance, chronic inflammation, hyperleptinemia, endothelial dysfunction, impaired respiratory function of mitochondria, minerals and microelements defi

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Bina K., Nalongo. "Microbiome Modulation in Obesity: Role of Prebiotics and Probiotics in Hyperlipidemia Control." INOSR EXPERIMENTAL SCIENCES 13, no. 12 (2020): 20–23. http://dx.doi.org/10.59298/inosres/2024/1332023.000.

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Obesity is a major global health issue associated with metabolic disorders such as hyperlipidemia, which predisposes individuals to cardiovascular diseases. Emerging evidence highlights the critical role of the gut microbiome in modulating host metabolism, including lipid homeostasis, making it a potential target for therapeutic interventions. Prebiotics and probiotics, which can beneficially alter gut microbial composition and function, have gained considerable attention as non-pharmacological strategies to mitigate obesity-related hyperlipidemia. This review explores the mechanisms by which

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Lukasiewicz, Martyna, Agata Zwara, Jacek Kowalski, Adriana Mika, and Andrzej Hellmann. "The Role of Lipid Metabolism Disorders in the Development of Thyroid Cancer." International Journal of Molecular Sciences 25, no. 13 (2024): 7129. http://dx.doi.org/10.3390/ijms25137129.

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Thyroid cancer (TC) is a neoplasm with an increasing incidence worldwide. Its etiology is complex and based on a multi-layered interplay of factors. Among these, disorders of lipid metabolism have emerged as an important area of investigation. Cancer cells are metabolically reprogrammed to promote their rapid growth, proliferation, and survival. This reprogramming is associated with significant changes at the level of lipids, mainly fatty acids (FA), as they play a critical role in maintaining cell structure, facilitating signaling pathways, and providing energy. These lipid-related changes he

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Vučević, Danijela, Drago Đorđević, Marija Stanojević, et al. "Hypercholesterolemias: Pathogenesis and pathophysiological implications." Medicinska istrazivanja 50, no. 2 (2016): 30–43. http://dx.doi.org/10.5937/medist1602030v.

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In this review, we provide an overview of recent literature data and practical knowledge related to hypercholesterolemias and their pathophysiological implications. Elevated blood lipid levels (hyperlipidaemias) are the most common metabolic disorders in global population. There is consensus regarding hypercholesterolemia, hypertension and cigarette smoking as the three main risk factors for atherothrombosis, with consequences such as cardiovascular and cerebrovascular diseases, being the leading cause of morbidity and mortality worldwide. In relation to this, familial hypercholesterolemia is

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Chazova, T. E., and G. A. Melnichenko. "Diabetes mellitus and coronary heart disease." Problems of Endocrinology 44, no. 1 (1998): 54. http://dx.doi.org/10.14341/probl199844154-54.

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Atherosclerosis and related disorders of carbohydrate metabolism go beyond narrow cardiological problems and, in one way or another, are the subject of close attention of doctors of various specialties, including endocrinologists. In everyday practice, most endocrinologists leave the solution of issues related to hyperlipidemia “for later”, because, first, for many decades, full compensation for diabetes and hypothyroidism - conditions in which secondary hyperlipidemia is most common - was difficult ; secondly, there were no effective and safe means for treating hyperlipidemia, which made gene

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He, Xin, Xinyu Gao, and Weidong Xie. "Research Progress in Skin Aging, Metabolism, and Related Products." International Journal of Molecular Sciences 24, no. 21 (2023): 15930. http://dx.doi.org/10.3390/ijms242115930.

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In recent years, skin aging has received increasing attention. Many factors affect skin aging, and research has shown that metabolism plays a vital role in skin aging, but there needs to be a more systematic review. This article reviews the interaction between skin metabolism and aging from the perspectives of glucose, protein, and lipid metabolism and explores relevant strategies for skin metabolism regulation. We found that skin aging affects the metabolism of three major substances, which are glucose, protein, and lipids, and the metabolism of the three major substances in the skin also aff

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Kotlyarov, Stanislav, and Anna Kotlyarova. "Molecular Mechanisms of Lipid Metabolism Disorders in Infectious Exacerbations of Chronic Obstructive Pulmonary Disease." International Journal of Molecular Sciences 22, no. 14 (2021): 7634. http://dx.doi.org/10.3390/ijms22147634.

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Exacerbations largely determine the character of the progression and prognosis of chronic obstructive pulmonary disease (COPD). Exacerbations are connected with changes in the microbiological landscape in the bronchi due to a violation of their immune homeostasis. Many metabolic and immune processes involved in COPD progression are associated with bacterial colonization of the bronchi. The objective of this review is the analysis of the molecular mechanisms of lipid metabolism and immune response disorders in the lungs in COPD exacerbations. The complex role of lipid metabolism disorders in th

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Kim, Dae-Yong, and Seong-Hee Ko. "Common Regulators of Lipid Metabolism and Bone Marrow Adiposity in Postmenopausal Women." Pharmaceuticals 16, no. 2 (2023): 322. http://dx.doi.org/10.3390/ph16020322.

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A variety of metabolic disorders are associated with a decrease in estradiol (E2) during natural or surgical menopause. Postmenopausal women are prone to excessive fat accumulation in skeletal muscle and adipose tissue due to the loss of E2 via abnormalities in lipid metabolism and serum lipid levels. In skeletal muscle and adipose tissue, genes related to energy metabolism and fatty acid oxidation, such as those encoding peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α) and estrogen-related receptor alpha (ERRα), are downregulated, leading to increased fat synthesis and lip

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Su, Hao, Dongsen Liu, Jia Shao, Yinuo Li, Xiaoxia Wang, and Qi Gao. "Aging Liver: Can Exercise be a Better Way to Delay the Process than Nutritional and Pharmacological Intervention? Focus on Lipid Metabolism." Current Pharmaceutical Design 26, no. 39 (2020): 4982–91. http://dx.doi.org/10.2174/1381612826666200605111232.

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Background & Aims: Nowadays, the world is facing a common problem that the population aging process is accelerating. How to delay metabolic disorders in middle-aged and elderly people, has become a hot scientific and social issue worthy of attention. The liver plays an important role in lipid metabolism, and abnormal lipid metabolism may lead to liver diseases. Exercise is an easily controlled and implemented intervention, which has attracted extensive attention in improving the health of liver lipid metabolism in the elderly. This article reviewed the body aging process, changes of lipid

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Chen, Lichun, Songwen Xue, Binhao Dai, and Huimin Zhao. "Effects of Coix Seed Oil on High Fat Diet-Induced Obesity and Dyslipidemia." Foods 11, no. 20 (2022): 3267. http://dx.doi.org/10.3390/foods11203267.

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Dietary intervention is becoming more popular as a way to improve lipid metabolism and reduce the prevalence of diet-related chronic disorders. We evaluated the effects of several dietary oils on body weight, fat mass, liver weight, and tumor necrosis factor in obese mice given a high-fat diet (HFD) to discover if coix seed oil (CSO) had an anti-obesity impact. As compared to other dietary fats, CSO treatment considerably lowered body weight and liver index, successfully sup-pressed total cholesterol and triglyceride content, and raised liver lipid deposition and lipid metabolism problem induc

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Titus, Stephen Dio, Allahnanan Emmanuel, Ezeonu Chukwuma Stephen, Silas Verwiyeh Tatah, and Kayode Adebisi Arowora. "Recent Advances in Lipid Metabolism and Regulations: A Review." Journal of Multidisciplinary Science: MIKAILALSYS 3, no. 1 (2025): 208–24. https://doi.org/10.58578/mikailalsys.v3i1.5044.

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Lipid metabolism is a highly intricate and tightly regulated process essential for cellular function, energy homeostasis, and metabolic balance. It encompasses lipid synthesis (lipogenesis), storage, breakdown (lipolysis and β-oxidation), and transport, all of which are orchestrated by complex regulatory networks involving enzymes, transcription factors, hormones, and environmental influences. Dysregulation of lipid metabolism is implicated in various metabolic disorders, including obesity, diabetes, cardiovascular disease, and metabolic syndrome. Recent advances in lipidomics, molecular biolo

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