Academic literature on the topic 'Lipid transporters'

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Journal articles on the topic "Lipid transporters"

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Hilgemann, Donald W., Gucan Dai, Anthony Collins, et al. "Lipid signaling to membrane proteins: From second messengers to membrane domains and adapter-free endocytosis." Journal of General Physiology 150, no. 2 (2018): 211–24. http://dx.doi.org/10.1085/jgp.201711875.

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Lipids influence powerfully the function of ion channels and transporters in two well-documented ways. A few lipids act as bona fide second messengers by binding to specific sites that control channel and transporter gating. Other lipids act nonspecifically by modifying the physical environment of channels and transporters, in particular the protein–membrane interface. In this short review, we first consider lipid signaling from this traditional viewpoint, highlighting innumerable Journal of General Physiology publications that have contributed to our present understanding. We then switch to o
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Dionysopoulou, Mariangela, and George Diallinas. "Impact of Membrane Lipids on UapA and AzgA Transporter Subcellular Localization and Activity in Aspergillus nidulans." Journal of Fungi 7, no. 7 (2021): 514. http://dx.doi.org/10.3390/jof7070514.

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Recent biochemical and biophysical evidence have established that membrane lipids, namely phospholipids, sphingolipids and sterols, are critical for the function of eukaryotic plasma membrane transporters. Here, we study the effect of selected membrane lipid biosynthesis mutations and of the ergosterol-related antifungal itraconazole on the subcellular localization, stability and transport kinetics of two well-studied purine transporters, UapA and AzgA, in Aspergillus nidulans. We show that genetic reduction in biosynthesis of ergosterol, sphingolipids or phosphoinositides arrest A. nidulans g
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Chen, Ru, Yasuyo Yamaoka, Yanbin Feng, Zhanyou Chi, Song Xue, and Fantao Kong. "Co-Expression of Lipid Transporters Simultaneously Enhances Oil and Starch Accumulation in the Green Microalga Chlamydomonas reinhardtii under Nitrogen Starvation." Metabolites 13, no. 1 (2023): 115. http://dx.doi.org/10.3390/metabo13010115.

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Lipid transporters synergistically contribute to oil accumulation under normal conditions in microalgae; however, their effects on lipid metabolism under stress conditions are unknown. Here, we examined the effect of the co-expression of lipid transporters, fatty acid transporters, (FAX1 and FAX2) and ABC transporter (ABCA2) on lipid metabolism and physiological changes in the green microalga Chlamydomonas under nitrogen (N) starvation. The results showed that the TAG content in FAX1-FAX2-ABCA2 over-expressor (OE) was 2.4-fold greater than in the parental line. Notably, in FAX1-FAX2-ABCA2-OE,
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Langmann, Thomas, Richard Mauerer, and Gerd Schmitz. "Human ATP-Binding Cassette Transporter TaqMan Low-Density Array: Analysis of Macrophage Differentiation and Foam Cell Formation." Clinical Chemistry 52, no. 2 (2006): 310–13. http://dx.doi.org/10.1373/clinchem.2005.059774.

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Abstract Background: ATP-binding cassette (ABC) transporters cause various diseases and regulate many physiologic processes, such as lipid homeostasis, iron transport, and immune mechanisms. Several ABC transporters are involved in bile acid, phospholipid, and sterol transport, and their expression is itself controlled by lipids. In addition, ABC proteins mediate drug export in tumor cells and promote the development of multidrug resistance. Methods: We created an ABC Transporter TaqMan Low-Density Array based on an Applied Biosystems 7900HT Micro Fluidic Card. We used a 2-μL reaction well wit
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Nagahashi, Masayuki, Kazuaki Takabe, Krista P. Terracina, et al. "Sphingosine-1-Phosphate Transporters as Targets for Cancer Therapy." BioMed Research International 2014 (2014): 1–7. http://dx.doi.org/10.1155/2014/651727.

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Sphingosine-1-phosphate (S1P) is a pleiotropic lipid mediator that regulates cell survival, migration, the recruitment of immune cells, angiogenesis, and lymphangiogenesis, all of which are involved in cancer progression. S1P is generated inside cancer cells by sphingosine kinases then exported outside of the cell into the tumor microenvironment where it binds to any of five G protein coupled receptors and proceeds to regulate a variety of functions. We have recently reported on the mechanisms underlying the “inside-out” signaling of S1P, its export through the plasma membrane, and its interac
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McKinlay, Colin J., Nancy L. Benner, Ole A. Haabeth, Robert M. Waymouth, and Paul A. Wender. "Enhanced mRNA delivery into lymphocytes enabled by lipid-varied libraries of charge-altering releasable transporters." Proceedings of the National Academy of Sciences 115, no. 26 (2018): E5859—E5866. http://dx.doi.org/10.1073/pnas.1805358115.

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We report a strategy for generating a combinatorial library of oligonucleotide transporters with varied lipid domains and their use in the efficient transfection of lymphocytes with mRNA in vitro and in vivo. This library is based on amphiphilic charge-altering releasable transporters (CARTs) that contain a lipophilic block functionalized with various side-chain lipids and a polycationic α-amino ester mRNA-binding block that undergoes rearrangement to neutral small molecules, resulting in mRNA release. We show that certain binary mixtures of these lipid-varied CARTs provide up to a ninefold en
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Kok, Jan Willem, Karin Klappe, and Ina Hummel. "The Role of the Actin Cytoskeleton and Lipid Rafts in the Localization and Function of the ABCC1 Transporter." Advances in Biology 2014 (May 5, 2014): 1–11. http://dx.doi.org/10.1155/2014/105898.

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ATP-binding cassette (ABC) transporters are known to be important factors in multidrug resistance of tumor cells. Lipid rafts have been implicated in their localization in the plasma membrane, where they function as drug efflux pumps. This specific localization in rafts may support the activity of ABC/Abc transporters. This raises questions regarding the nature and composition of the lipid rafts that harbor ABC/Abc transporters and the dependence of ABC/Abc transporters—concerning their localization and activity—on lipid raft constituents. Here we review our work of the past 10 years aimed at
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Kotlyarov, S. N., and A. A. Kotlyarova. "Participation of ABC-transporters in lipid metabolism and pathogenesis of atherosclerosis." Genes & Cells 15, no. 3 (2020): 22–28. http://dx.doi.org/10.23868/202011003.

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Atherosclerosis is one of the key causes of morbidity and mortality worldwide. It is known that a leading role in the development and progression of atherosclerosis is played by a violation of lipid metabolism. ABC transporters provide lipid cell homeostasis, performing a number of transport functions - moving lipids inside the cell, in the plasma membrane, and also removing lipids from the cell. In a large group of ABC transporters, about 20 take part in lipid homeostasis, playing, among other things, an important role in the pathogenesis of atherosclerosis. It was shown that cholesterol is n
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Kotlyarov, Stanislav, and Anna Kotlyarova. "The Role of ABC Transporters in Lipid Metabolism and the Comorbid Course of Chronic Obstructive Pulmonary Disease and Atherosclerosis." International Journal of Molecular Sciences 22, no. 13 (2021): 6711. http://dx.doi.org/10.3390/ijms22136711.

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Chronic obstructive pulmonary disease (COPD) ranks among the leading causes of morbidity and mortality worldwide. COPD rarely occurs in isolation and is often combined with various diseases. It is considered that systemic inflammation underlies the comorbid course of COPD. The data obtained in recent years have shown the importance of violations of the cross-links of lipid metabolism and the immune response, which are links in the pathogenesis of both COPD and atherosclerosis. The role of lipid metabolism disorders in the pathogenesis of the comorbid course of COPD and atherosclerosis and the
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Jedlitschky, Gabriele, Andreas Greinacher, and Heyo K. Kroemer. "Transporters in human platelets: physiologic function and impact for pharmacotherapy." Blood 119, no. 15 (2012): 3394–402. http://dx.doi.org/10.1182/blood-2011-09-336933.

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Platelets store signaling molecules (eg, serotonin and ADP) within their granules. Transporters mediate accumulation of these molecules in platelet granules and, on platelet activation, their translocation across the plasma membrane. The balance between transporter-mediated uptake and elimination of signaling molecules and drugs in platelets determines their intracellular concentrations and effects. Several members of the 2 major transporter families, ATP-binding cassette (ABC) transporters and solute carriers (SLCs), have been identified in platelets. An example of an ABC transporter is MRP4
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Dissertations / Theses on the topic "Lipid transporters"

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Raggers, René John. "Lipid translocation by multidrug transporters." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2001. http://dare.uva.nl/document/60218.

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Alrosan, Amjad. "Characterization of Interacting Partners of ABC Lipid Transporters." Thesis, University of Sydney, 2020. https://hdl.handle.net/2123/22999.

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This thesis outlines a series of experimental approaches that aim to investigate the roles of the co-factor Alix (apoptosis-linked gene 2-interacting protein X), the deubiquitinase USP9X (Ubiquitin-specific protease 9, X-linked), and sterols, including cholesterol synthesis intermediates and oxysterols, in the post-translational regulation of ATP-binding cassette (ABC) lipid transporters, ABCG1 and ABCG4. Alix and USP9X were identified in our laboratory using peptide mass spectrometry analysis as binding partners of ABCG1. The experiments presented in the following chapters characterize the ef
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Charalambous, Kalypso Nicola. "The effect of lipid bilayer composition on small multidrug resistance transporters." Thesis, University of Bristol, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.432740.

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Wei, Liang Shen. "Drug and lipid interactions on the ABC transporters ABCG1 and MsbA." Thesis, University of Cambridge, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609340.

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Frangos, Zachary Joseph. "Investigating the molecular mechanism of bioactive lipid inhibitors of GlyT2." Thesis, The University of Sydney, 2022. https://hdl.handle.net/2123/28029.

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Lipid modulation of glycine transport has attracted significant attention as a potential analgesic pathway for neuropathic pain conditions. An array of bioactive lipids that potently inhibit GlyT2 have recently been developed with one compound, C18 ω9 D-lysine (IC50 = 48 nM), demonstrating metabolic stability and analgesic properties in a neuropathic pain model. Despite this, the clinical viability of these bioactive lipids is limited due to their significant lipophilicity preventing effective clearance from the CNS. The first aim of my study was to perform structure activity relationships on
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Aleidi, Shereen Mohammad Suleimann. "Characterization of the Post-Translational Regulation of the ABCA1 and ABCG1 Lipid Transporters by E3 Ligases." Thesis, The University of Sydney, 2016. http://hdl.handle.net/2123/15477.

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This thesis present a series of experimental approaches that aim to characterize the roles of three E3 ubiquitin ligase enzymes in the post-translational regulation of two ABC lipid transporters; ABCA1 and ABCG1. These E3 ligases, namely HECTD1 ( Homologous to E6Ap C-terminus Domain 1), HUWE1 (HECT, UBA, and WWE domain containing 1), and NEDD4-1 (Neural precursor cell-expressed developmentally down regulated gene 4), were identified during a previous work in our laboratory using peptide mass spectrometry analysis as associate proteins with ABCG1. The experiments presented in the following chap
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Chantemargue, Benjamin. "In silico investigation of xenobiotic interactions with lipid bilayers and ABC membrane transporters, the case of ABCC4/MRP4." Thesis, Limoges, 2018. http://www.theses.fr/2018LIMO0077/document.

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L’appréhension des mécanismes d’action biologiques des protéines membranaires nécessite de comprendre les interactions des xénobiotiques avec ces protéines et avec les membranes lipidiques. Les méthodes expérimentales sont parfois coûteuses et ne permettent d’obtenir que des informations partielles sur les interactions xénobiotiques-membrane-protéine. La modélisation moléculaire est une sérieuse alternative. Les simulations de dynamique moléculaire et de dynamique biaisées ont ouvert de nombreuses perspectives en permettant de décrire ces interactions moléculaires à l’échelle atomique. Grâce à
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Basante-Bedoya, Miguel Angel. "Transporteurs lipidiques dans la morphogenèse du champignon pathogène opportuniste de l’Homme Candida albicans." Electronic Thesis or Diss., Université Côte d'Azur, 2021. http://theses.univ-cotedazur.fr/2021COAZ6030.

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Candida albicans est un champignon pathogène opportuniste de l'homme qui peut causer des infections superficielles ou systémiques; sa capacité à passer d'une forme ovoïde à une forme filamenteuse est associée à sa virulence. Pendant cette croissance filamenteuse hautement polarisée, une accumulation de vésicules (Spitzenkörper), caractéristique des champignons filamenteux, ainsi qu'une distribution enrichie de lipides, tels que l'ergostérol, les dérivés phosphorylés du phosphatidylinositol (PI(4)P, PI(4,5)P2) et la phosphatidylsérine (PS) est observée à l'apex des filaments. Cependant, l'impor
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Lacabanne, Denis. "Solid-state NMR studies of the ABC transporter BmrA in its lipid environment." Thesis, Lyon, 2017. http://www.theses.fr/2017LYSE1243/document.

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Les transporteurs à ATP binding cassette (ABC) peuvent transporter une grande variété de substrats utilisant l'ATP-Mg2+ comme source d'énergie. Ces transporteurs sont présents dans toutes les formes de vie et sont impliqués dans la résistance aux médicaments, comprenant les anticancéreux et les antibiotiques. Mes travaux de thèse se concentrent sur le transporteur BmrA (130 kDa) de Bacillus subtilis utilisé en tant que système modèle et homologue de la P-glycoprotéine humaine impliquée dans la multirésistance aux anticancéreux. Dans ces travaux nous montrons que la reconstitution de cette prot
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Mathey, Aline. "Nouvelles stratégies thérapeutiques et chimiorésistance : molécules bioactives et métabolisme lipidique." Electronic Thesis or Diss., Bourgogne Franche-Comté, 2023. http://www.theses.fr/2023UBFCI014.

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De nombreux échecs thérapeutiques persistent à cause de mécanismes d’adaptation et de résistance tumorale, tels que l’insensibilité aux signaux de mort cellulaire, la surexpression de transporteurs d’efflux de drogues (i.e. les transporteurs ABC caractéristiques du phénotype de résistance multiple aux drogues ou MDR), des mutations dans les voies de détection et de réparation des dommages à l’ADN ou encore une reprogrammation du métabolisme énergétique. Plus particulièrement, de plus en plus d’études suggèrent que des dérégulations du métabolisme des lipides de la mitochondrie, les cardiolipin
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Books on the topic "Lipid transporters"

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Gulati, Sonia. Characterizing the Interaction of the ATP Binding Cassette Transporters (G subfamily) with the Intracellular Protein Lipid Environment. [publisher not identified], 2011.

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universitet, Uppsala, ed. Chromatographic analyses of solute interactions with the glucose transporter Glut1, liposomes and SDS micelles. Acta Universitatis Upsaliensis, 1997.

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Book chapters on the topic "Lipid transporters"

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Nagao, Kohjiro, Naoto Juni, and Masato Umeda. "Membrane Lipid Transporters in Drosophila melanogaster." In Bioactive Lipid Mediators. Springer Japan, 2015. http://dx.doi.org/10.1007/978-4-431-55669-5_12.

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Apell, Hans-Jürgen, and Valerij S. Sokolov. "Study of Ion Pump Activity Using Black Lipid Membranes." In Pumps, Channels, and Transporters. John Wiley & Sons, Inc, 2015. http://dx.doi.org/10.1002/9781119085126.ch2.

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Hisano, Yu, Tsuyoshi Nishi, and Atsuo Kawahara. "Sphingosine 1-Phosphate Signaling via Transporters in Zebrafish and Mice." In Bioactive Lipid Mediators. Springer Japan, 2015. http://dx.doi.org/10.1007/978-4-431-55669-5_15.

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Marcel, Yves L., Mireille Ouimet, and Ming-Dong Wang. "Cellular Lipid Traffic and Lipid Transporters: Regulation of Efflux and HDL Formation." In Cellular Lipid Metabolism. Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-642-00300-4_3.

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Salajegheh, Ali. "Adenosine Triphosphate-Binding Cassette (ABC) Lipid Transporters." In Angiogenesis in Health, Disease and Malignancy. Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-28140-7_2.

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Modi, Chetna, Kaushik Kanada, Bhupendra Prajapati, Sohansinh Vaghela, and Hiteshi Chadhaa. "Transfersomes as Transporters via Lipid-Based Drug Delivery System." In Lipid-Based Drug Delivery Systems. Jenny Stanford Publishing, 2023. http://dx.doi.org/10.1201/9781003459811-7.

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Bonen, Arend, Joost J. F. R. Luiken, and Jan F. C. Glatz. "Regulation of fatty acid transport and membrane transporters in health and disease." In Cellular Lipid Binding Proteins. Springer US, 2002. http://dx.doi.org/10.1007/978-1-4419-9270-3_23.

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Alpy, Fabien, and Catherine L. Tomasetto. "STARD3: A Lipid Transfer Protein in Breast Cancer and Cholesterol Trafficking." In Cholesterol Transporters of the START Domain Protein Family in Health and Disease. Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-1112-7_6.

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Iaea, David B., Shu Mao, and Frederick R. Maxfield. "Steroidogenic Acute Regulatory Protein-related Lipid Transfer (START) Proteins in Non-vesicular Cholesterol Transport." In Cholesterol Transporters of the START Domain Protein Family in Health and Disease. Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-1112-7_8.

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Clark, Barbara J., and Douglas M. Stocco. "An Introduction to the Steroidogenic Acute Regulatory Protein (StAR)-Related Lipid Transfer Domain Protein Family." In Cholesterol Transporters of the START Domain Protein Family in Health and Disease. Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-1112-7_1.

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Conference papers on the topic "Lipid transporters"

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Sundaresan, Vishnu Baba, and Donald J. Leo. "Actuation Using Protein Transporters Driven by Proton Gradient." In ASME 2006 International Mechanical Engineering Congress and Exposition. ASMEDC, 2006. http://dx.doi.org/10.1115/imece2006-15523.

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A new mechanical actuation concept is demonstrated based on the controlled transport of fluid across semipermeable membranes. This concept is based on the pressurization of cells similar to the process that plants use to maintain homeostasis and regulate cell function. In all plant systems, the transport of ions and fluid produce localized pressure changes (called turgor pressure) that perform many cell functions, such as maintaining cell integrity and controlling plant growth. In this paper we demonstrate that the concept of fluid transport caused by protein transporters can be used to contro
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Makhoul-Mansour, Michelle M., and Eric C. Freeman. "Photo-Triggered Soft Materials With Differentiated Diffusive Pathways." In ASME 2019 Conference on Smart Materials, Adaptive Structures and Intelligent Systems. American Society of Mechanical Engineers, 2019. http://dx.doi.org/10.1115/smasis2019-5525.

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Abstract Controlled diffusive transport between regions within a compartmentalized structure is an essential feature of cellular-inspired materials. Using the droplet interface bilayer (DIB) technique, biomolecular soft materials can be constructed in an oil medium by connecting multiple lipid-coated microdroplets together through interfacial bilayers. While traditionally achieved through the incorporation of pore forming toxins (PFTs), signal propagation within DIB assemblies can be remotely controlled through the integration of photopolymerizable phospholipids (23:2 DiynePC) into the aqueous
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Sundaresan, Vishnu Baba, and Donald J. Leo. "Experimental Investigation for Chemo-Mechanical Actuation Using Biological Transport Mechanisms." In ASME 2005 International Mechanical Engineering Congress and Exposition. ASMEDC, 2005. http://dx.doi.org/10.1115/imece2005-81366.

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Plants have the ability to develop large mechanical force from chemical energy available with bio-fuels. The energy released by the cleavage of a terminal phosphate ion during the hydrolysis of bio-fuel assists the transport of ions and fluids in cellular homeostasis. Materials that develop pressure and hence strain similar to the response of plants to an external stimuli are classified as nastic materials. Calculations for controlled actuation of an active material inspired by biological transport mechanism demonstrated the feasibility of developing such a material with actuation energy densi
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Malcata, F. Xavier. "Engineering of microalgae toward biodiesel: Facts and prospects." In 2022 AOCS Annual Meeting & Expo. American Oil Chemists' Society (AOCS), 2022. http://dx.doi.org/10.21748/jeul5047.

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Excessive release to the atmosphere of greenhouse-effect gases—arising from combustion of fossil fuels, has urged a worldwide search for alternative sources of environment-friendly fuels; microalgae constitute an interesting possibility, owing to their widespread presence in most habitats and unique ability to synthesize oil. Microalgae require indeed only sunlight and water to grow—both freely available; together with CO2 as source of carbon—which concomitantly conveys a path for its direct sequestering from the atmosphere; and low-cost inorganic sources of phosphorus and nitrogen. However, t
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Zibert, A., S. Guttmann, and HH Schmidt. "New role of copper transporter ATP7B in lipid metabolism of enterocytes." In 36. Jahrestagung der Deutschen Arbeitsgemeinschaft zum Studium der Leber. Georg Thieme Verlag KG, 2020. http://dx.doi.org/10.1055/s-0039-3402196.

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Sundaresan, Vishnu Baba, and Donald J. Leo. "Modeling and Characterization of a Chemomechanical Actuator Based on Protein Transporters." In ASME 2007 International Mechanical Engineering Congress and Exposition. ASMEDC, 2007. http://dx.doi.org/10.1115/imece2007-43712.

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Plants and animal cells are naturally occurring actuators that exhibit force and motion driven by fluid transport through the cell membrane. The protein transporters embedded in the cell membrane serve as the selective gateway for ion and fluid transport. The actuator presented in this work generates force and deformation from mass transport through an artificial membrane with protein transporters extracted from plant cell membranes. The artificial membrane is formed from purified 1-Palmitoyl-2-Oleoyl-sn-Glycero-3-[Phospho-L-Serine] (Sodium Salt) (POPS), 1-Palmitoyl-2-Oleoyl-sn-Glycero-3-Phosp
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Chowdhury, Saiful M., Xuewei Zhu, Jason G. Williams, et al. "ATP Binding Cassette Transporter A1 Regulates The Lipid Raft Proteome Of The Macrophage." In American Thoracic Society 2012 International Conference, May 18-23, 2012 • San Francisco, California. American Thoracic Society, 2012. http://dx.doi.org/10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a1970.

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Dixon, J. Brandon. "Engineering Tools for Studying the Interplay Between Mechanics and Biology in Lymphatic Lipid Transport." In ASME 2010 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2010. http://dx.doi.org/10.1115/sbc2010-19364.

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The lymphatic vasculature extends through most tissues of the body and plays an essential role in maintaining fluid balance, immune cell trafficking, and lipid transport. Nearly all dietary lipid is transported from the intestine to the circulation via the lymphatic system in the form of triglyceride-rich lipoproteins called chylomicrons. This process can be described through two different mechanisms: 1) entry of the chylomicron into the initial lymphatic vessels of the small intestine, known as lacteals, and 2) the transport of these chylomicrons through the larger collecting lymphatics by a
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Nara, Matsunori. "Invention Using a Liposome of a Bio-Micromachine." In ASME 4th Integrated Nanosystems Conference. ASMEDC, 2005. http://dx.doi.org/10.1115/nano2005-87031.

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It is thought that a minus hydrogen ion is useful to the apotosis of a mitochondria and prevention of a necrosis, or prevention of the illness resulting from the oxygen radical in a human body. So, in this research, examination about the possibility and its practical use method of production of the hydrogen ion by which it was minus electrified was performed. First, the lipid bilayer as a medicine transporter of DDS (Drug Delivery System) was produced using the supercritical fluid. Next, experimental examination was performed for the purpose of enclosing the substance for hydrogen ion generati
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Mulugeta, S., and M. Zhao. "Chronic Expression of an Aberrantly Trafficked Mutant ABCA3 Lipid Transporter Promotes Selective Upregulation of the Unfolded Protein Response and Increased Amphisome-Mediated Autophagy." In American Thoracic Society 2021 International Conference, May 14-19, 2021 - San Diego, CA. American Thoracic Society, 2021. http://dx.doi.org/10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a4248.

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Reports on the topic "Lipid transporters"

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Cai, TingYu, Li Zhang, Ting Yang, and Yang Gao. Effects of different dosages of Sodium-Glucose Transporter 2 Inhibitors on lipid levels in patients with type 2 diabetes mellitus: a systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review Protocols, 2020. http://dx.doi.org/10.37766/inplasy2020.4.0201.

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Barg, Rivka, Kendal D. Hirschi, Avner Silber, Gozal Ben-Hayyim, Yechiam Salts, and Marla Binzel. Combining Elevated Levels of Membrane Fatty Acid Desaturation and Vacuolar H+ -pyrophosphatase Activity for Improved Drought Tolerance. United States Department of Agriculture, 2012. http://dx.doi.org/10.32747/2012.7613877.bard.

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Background to the topic: In previous works we have shown that Arabidopsis and tomato over-expressing H+-pyrophosphatase show increased tolerance to drought imposed by withholding irrigation of young plants in pots (Park et al. 2005). In addition, young tobacco plants over-expressing fatty acid desaturase 3 (OEX-FAD3) also showed increasing tolerance to drought stress (Zhang et al 2005), and similarly OEX-FAD3 young tomato plants (unpublished data from ARO), hence raising the possibility that pyramiding the two could further improve drought tolerance in tomato. Based on these findings the speci
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