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Dissertations / Theses on the topic 'Lipid transporters'

Author: Grafiati

Published: 6 July 2024

Last updated: 31 July 2025

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1

Raggers, René John. "Lipid translocation by multidrug transporters." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2001. http://dare.uva.nl/document/60218.

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2

Alrosan, Amjad. "Characterization of Interacting Partners of ABC Lipid Transporters." Thesis, University of Sydney, 2020. https://hdl.handle.net/2123/22999.

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This thesis outlines a series of experimental approaches that aim to investigate the roles of the co-factor Alix (apoptosis-linked gene 2-interacting protein X), the deubiquitinase USP9X (Ubiquitin-specific protease 9, X-linked), and sterols, including cholesterol synthesis intermediates and oxysterols, in the post-translational regulation of ATP-binding cassette (ABC) lipid transporters, ABCG1 and ABCG4. Alix and USP9X were identified in our laboratory using peptide mass spectrometry analysis as binding partners of ABCG1. The experiments presented in the following chapters characterize the ef

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3

Charalambous, Kalypso Nicola. "The effect of lipid bilayer composition on small multidrug resistance transporters." Thesis, University of Bristol, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.432740.

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4

Wei, Liang Shen. "Drug and lipid interactions on the ABC transporters ABCG1 and MsbA." Thesis, University of Cambridge, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609340.

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5

Frangos, Zachary Joseph. "Investigating the molecular mechanism of bioactive lipid inhibitors of GlyT2." Thesis, The University of Sydney, 2022. https://hdl.handle.net/2123/28029.

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Lipid modulation of glycine transport has attracted significant attention as a potential analgesic pathway for neuropathic pain conditions. An array of bioactive lipids that potently inhibit GlyT2 have recently been developed with one compound, C18 ω9 D-lysine (IC50 = 48 nM), demonstrating metabolic stability and analgesic properties in a neuropathic pain model. Despite this, the clinical viability of these bioactive lipids is limited due to their significant lipophilicity preventing effective clearance from the CNS. The first aim of my study was to perform structure activity relationships on

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6

Aleidi, Shereen Mohammad Suleimann. "Characterization of the Post-Translational Regulation of the ABCA1 and ABCG1 Lipid Transporters by E3 Ligases." Thesis, The University of Sydney, 2016. http://hdl.handle.net/2123/15477.

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This thesis present a series of experimental approaches that aim to characterize the roles of three E3 ubiquitin ligase enzymes in the post-translational regulation of two ABC lipid transporters; ABCA1 and ABCG1. These E3 ligases, namely HECTD1 ( Homologous to E6Ap C-terminus Domain 1), HUWE1 (HECT, UBA, and WWE domain containing 1), and NEDD4-1 (Neural precursor cell-expressed developmentally down regulated gene 4), were identified during a previous work in our laboratory using peptide mass spectrometry analysis as associate proteins with ABCG1. The experiments presented in the following chap

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7

Chantemargue, Benjamin. "In silico investigation of xenobiotic interactions with lipid bilayers and ABC membrane transporters, the case of ABCC4/MRP4." Thesis, Limoges, 2018. http://www.theses.fr/2018LIMO0077/document.

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L’appréhension des mécanismes d’action biologiques des protéines membranaires nécessite de comprendre les interactions des xénobiotiques avec ces protéines et avec les membranes lipidiques. Les méthodes expérimentales sont parfois coûteuses et ne permettent d’obtenir que des informations partielles sur les interactions xénobiotiques-membrane-protéine. La modélisation moléculaire est une sérieuse alternative. Les simulations de dynamique moléculaire et de dynamique biaisées ont ouvert de nombreuses perspectives en permettant de décrire ces interactions moléculaires à l’échelle atomique. Grâce à

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8

Basante-Bedoya, Miguel Angel. "Transporteurs lipidiques dans la morphogenèse du champignon pathogène opportuniste de l’Homme Candida albicans." Electronic Thesis or Diss., Université Côte d'Azur, 2021. http://theses.univ-cotedazur.fr/2021COAZ6030.

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Candida albicans est un champignon pathogène opportuniste de l'homme qui peut causer des infections superficielles ou systémiques; sa capacité à passer d'une forme ovoïde à une forme filamenteuse est associée à sa virulence. Pendant cette croissance filamenteuse hautement polarisée, une accumulation de vésicules (Spitzenkörper), caractéristique des champignons filamenteux, ainsi qu'une distribution enrichie de lipides, tels que l'ergostérol, les dérivés phosphorylés du phosphatidylinositol (PI(4)P, PI(4,5)P2) et la phosphatidylsérine (PS) est observée à l'apex des filaments. Cependant, l'impor

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9

Lacabanne, Denis. "Solid-state NMR studies of the ABC transporter BmrA in its lipid environment." Thesis, Lyon, 2017. http://www.theses.fr/2017LYSE1243/document.

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Les transporteurs à ATP binding cassette (ABC) peuvent transporter une grande variété de substrats utilisant l'ATP-Mg2+ comme source d'énergie. Ces transporteurs sont présents dans toutes les formes de vie et sont impliqués dans la résistance aux médicaments, comprenant les anticancéreux et les antibiotiques. Mes travaux de thèse se concentrent sur le transporteur BmrA (130 kDa) de Bacillus subtilis utilisé en tant que système modèle et homologue de la P-glycoprotéine humaine impliquée dans la multirésistance aux anticancéreux. Dans ces travaux nous montrons que la reconstitution de cette prot

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10

Mathey, Aline. "Nouvelles stratégies thérapeutiques et chimiorésistance : molécules bioactives et métabolisme lipidique." Electronic Thesis or Diss., Bourgogne Franche-Comté, 2023. http://www.theses.fr/2023UBFCI014.

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De nombreux échecs thérapeutiques persistent à cause de mécanismes d’adaptation et de résistance tumorale, tels que l’insensibilité aux signaux de mort cellulaire, la surexpression de transporteurs d’efflux de drogues (i.e. les transporteurs ABC caractéristiques du phénotype de résistance multiple aux drogues ou MDR), des mutations dans les voies de détection et de réparation des dommages à l’ADN ou encore une reprogrammation du métabolisme énergétique. Plus particulièrement, de plus en plus d’études suggèrent que des dérégulations du métabolisme des lipides de la mitochondrie, les cardiolipin

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11

Azouaoui, Hassina. "Étude structurale et fonctionnelle d’un transporteur de lipides « une flippase » de la levure S. cerevisiae : l’ATPase P4 Drs2p et sa sous unité-associée Cdc50p." Thesis, Université Paris-Saclay (ComUE), 2016. http://www.theses.fr/2016SACLS224/document.

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Les ATPases-P4 sont des transporteurs membranaires couplant l'hydrolyse de l'ATP au transport de lipides dans les membranes cellulaires eucaryotes. Avec leurs partenaires, les protéines CDC50, les ATPases-P4 transportent les phospholipides, en particulier la phosphatidylsérine (PS) et la phosphatidyléthanolamine (PE), du feuillet exoplasmique au feuillet cytosolique des membranes, assurant ainsi le maintien de l'asymétrie membranaire.Drs2p est l'une des cinq ATPases-P4 de la levure Saccharomyces cerevisiae. Elle est localisée dans les membranes du trans-Golgi (TGN), et elle a comme partenaire

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12

Wang, Yuhuan. "ROLES OF ABCG5 ABCG8 CHOLESTEROL TRANSPORTER IN LIPID HOMEOSTASIS." UKnowledge, 2015. http://uknowledge.uky.edu/pharmacy_etds/50.

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The ABCG5 ABCG8 (G5G8) sterol transporter promotes cholesterol secretion into bile and opposes dietary sterol absorption in the small intestine. An emerging body of literature suggests that G5G8 links sterol flux to various risk factors for metabolic syndrome (MetS) and nonalcoholic fatty liver disease (NAFLD). Therapeutic approaches that accelerate G5G8 activity may augment reverse cholesterol transport (RCT) and provide beneficial effects in the prevention and treatment of cardiovascular and liver disease. Mice lacking leptin (ob/ob) or its receptor (db/db) are obese, insulin resistant in pa

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13

McIlwain, Benjamin Carl. "Pharmacology and Lipid Sensitivity of the Prokaryotic Aspartate Transporter, GltPh." Thesis, The University of Sydney, 2016. http://hdl.handle.net/2123/15002.

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The aspartate transporter from Pyroccocus horikoshii, GltPh, is a model for the structure of the SLC1 family of amino acid transporters. Crystal structures of GltPh provide insight into mechanisms of ion coupling and substrate transport; however, structures have been solved in the absence of a lipid bilayer so they provide limited information regarding interactions that occur between the protein and lipids of the membrane. In this thesis, I have investigated the effect of the lipid environment on aspartate transport by reconstituting GltPh into liposomes of defined lipid composition. Here I sh

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14

Mostyn, Shannon. "HEADS OR TAILS: LIPID INHIBITORS OF THE GLYCINE TRANSPORTER, GLYT2." Thesis, The University of Sydney, 2018. http://hdl.handle.net/2123/18939.

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Membrane proteins are influenced by the dynamic lipid membrane environment, which can impart stability, mediate protein interactions, and provide highly selective contacts essential for function. Membrane proteins can also bind endogenous lipid ligands or are able to be allosterically modulated by lipids, many of which are thought to access their specific binding sites via the cell membrane. N-arachidonyl glycine (NAGly) is a bioactive lipid that is found in its highest concentrations within the spinal cord and may play an important role in endogenous regulation of glycinergic neurotransmissio

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15

Taylor, Andrew Mark. "Biophysical studies on the human erythrocyte anion transporter, band 3." Thesis, University of Oxford, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.360571.

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16

Krupski-Romsicki, Yolanda. "Modulation of the function of the P-glycoprotein multidrug transporter by lipid environment." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0001/NQ43271.pdf.

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17

Quazi, Faraz. "The role of photoreceptor ABC transporter ABCA4 in retinal and lipid transport and Stargardt macular degeneration." Thesis, University of British Columbia, 2013. http://hdl.handle.net/2429/45626.

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ABCA4 is a member of the superfamily of ATP-binding cassette (ABC) transporters implicated in the clearance of retinoids from photoreceptor outer segments and associated with Stargardt macular degeneration. Stargardt patients display lipofuscin deposits and photoreceptor degeneration that invariably lead to the loss of central vision. In biochemical and knockout mice studies, ABCA4 has been implicated in the transport of N-retinylidene-PE, the Schiff base conjugate formed from all-trans retinal and phosphatidylethanolamine (PE). The principal challenge in assessing direction and transport has

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18

Butchbach, Matthew E. R. "Regulation of glutamate transport by GTRAP3-18 and by lipid rafts." Connect to this title online, 2003. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1054650123.

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Thesis (Ph. D.)--Ohio State University, 2003.<br>Title from first page of PDF file. Document formatted into pages; contains xviii, 160 p.; also includes graphics Includes bibliographical references (p. 132-160). Available online via OhioLINK's ETD Center

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19

Sasaki, Mayumi. "Cloning of ABCA17, a novel rodent sperm-specific ABC (ATP-binding cassette) transporter that regulates intracellular lipid metabolism." Kyoto University, 2007. http://hdl.handle.net/2433/135646.

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20

Sands, Eric R. "Cloning and Expression of Thermophilic, Mesophilic, and Psychrophilic Zn2+ Transporting ATPases." Digital WPI, 2006. https://digitalcommons.wpi.edu/etd-theses/699.

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Protein folding and stability are essential for protein function. Changes in these characteristics can lead to altered physiological states and to the development of certain pathologies. While extensive research has focused on the stability of soluble proteins, membrane protein stability has received much less attention. Understanding the stability of membrane proteins can provide insight into folding mechanisms and the etiology of various pathologies. The purpose of this project is to prepare molecular tools to perform comparative studies of homologous membrane proteins that are found in

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21

Snider, Shayne. "Choline Transport Links Phospholipid Metabolism and Inflammation in Macrophages." Thesis, Université d'Ottawa / University of Ottawa, 2017. http://hdl.handle.net/10393/35715.

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Choline is necessary for the synthesis of phosphatidylcholine (PC), the predominant phospholipid species and an important lipid intermediate. Macrophages, critical mediators of innate immunity, have been implicated in lipid dysregulation associated with metabolic disease. Despite the importance of choline in lipid metabolism, few studies have investigated the relationship between choline metabolism and inflammation. My research revealed that macrophage polarization increased choline metabolism and the expression of the choline transporter CTL1. In addition, choline deficient macrophages showed

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22

Johnson, Soraya Sarah. "Control of the protein and lipid content of the plasma membrane by ATP-binding cassette transporter proteins in S. Cerevisiae." Diss., University of Iowa, 2010. https://ir.uiowa.edu/etd/825.

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Pdr5 and Yor1 are two ATP-binding cassette transporters regulated by the pleiotropic drug resistance (PDR) network in the yeast Saccharomyces cerevisiae. Recent work from another group demonstrated that a pdr5Δ yor1 strain confers remarkable resistance to a sphingolipid intermediate, phytosphingosine (PHS), which was surprising as loss of these transporters normally leads to elevated drug sensitivity. PHS is toxic to the cell at high levels due to mislocalization of nutrient permeases, such as the high affinity tryptophan transporter, Tat2. Although the above study suggested that this resistan

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23

Jain, Deepak M. "Effect of corn fibre oil and its constituents on cholesterol metabolism and intestinal sterol transporter gene expression in hamsters." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=98732.

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The cholesterol-lowering effect of corn fiber oil, obtained from the seed coats of corn kernels, has been reported previously. Corn fiber oil contains phytosteryl fatty acyl esters, ferulate phytostanyl esters, and free phytosterols. To date, however, no studies have examined the cholesterol-lowering efficacy of ferulate phytostanyl esters. Moreover, although plant stanols and sterols have been established as cholesterol-lowering agents over the past five decades, their exact mechanisms of action are not clearly understood. One of the possible mechanism is that plant sterols/stanols disrupts t

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24

Lima, Alex da Silva. "Uso da microscopia eletroquímica de varredura (SECM) no estudo de sistemas micelares e do transporte de espécies químicas através de membranas lipídicas." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/46/46136/tde-01102015-084001/.

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A presente tese versa sobre resultados obtidos na aplicação da microscopia eletroquímica de varredura no estudo de sistemas micelares e no estudo de bicamadas lipídicas. Os estudos envolvendo sistemas micelares foram realizados utilizando a SECM no modo substrato-gerador/microeletrodo-coletor. Neste modo de operação, um microeletrodo de platina foi posicionado próximo a um substrato de platina e utilizado para monitorar espécies eletrogeradas nesse substrato. Conhecendo o tempo necessário para a espécie eletrogerada difundir do substrato até o microeletrodo, foi possível aplicar a equação de E

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25

Kaniti, Archana. "Etudes du mode d'action antipaludique de nouveaux bis-cations." Thesis, Montpellier 2, 2010. http://www.theses.fr/2010MON20154.

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Dans cette thèse, j'ai essayé d'identifier le mode d'action de composés biscationiques récemment synthétisés et leurs interactions avec les parasites résistants à la chloroquine. Les activités de divers représentants des composés ammonium bisquaternaire, des amidines alkyl (provenant du groupe de professeur Vial, Montpellier, France), des amidines bisbenzyl (provenant du groupe Chimie de l'Université de Liverpool, Royaume-Uni) ont été comparés à la chloroquine et la pentamidine. Leurs potentiels de résistance croisée avec la chloroquine ont également été étudiés. Dans ce but, deux lignées cell

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26

Li, Hao. "In vitro Studies of Genodermatoses Affecting Cytoskeletal Integrity and Lipid Processing in Human Epidermis : Pathogenic Mechanisms and Effects of Retinoid Therapy." Doctoral thesis, Uppsala universitet, Institutionen för medicinska vetenskaper, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-172863.

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Autosomal dominant epidermolytic ichthyosis (EI) is a rare disease characterized by intra-epidermal blistering due to mutations in either of two keratin genes, KRT1 and KRT10, expressed by suprabasal keratinocytes. Autosomal recessive congenital ichthyosis (ARCI) is a non-blistering, hyperkeratotic disease caused by mutations in one of the following genes: ABCA12, ALOX12B, ALOXE3, TGM1, CYP4F22, NIPAL4 and SLC27A4, which are all essential for skin barrier homeostasis. ARCI and EI often respond well to treatment with retinoids, but the mechanism of action is unclear. The aim of this thesis was

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Rodrigues, Alice Cristina. "Efeito da atorvastatina sobre a atividade funcional e expressão de transportadores de membrana do tipo ABC e SLC." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/9/9136/tde-19052009-200620/.

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Os transportadores de membrana do tipo ATP Binding Cassette (ABC) e solute carriers (SLC) regulam a homeostase intracelular de fármacos, modificando a biodisponibilidade e possivelmente a eficácia terapêutica. A variabilidade na resposta a hipolipemiantes, como as vastatinas, tem sido associada a vários fatores genéticos e ambientais. Com a finalidade de avaliarmos os mecanismos de regulação da expressão dos transportadores pela atorvastatina, a expressão de RNAm de transportadores ABC (ABCB1, ABCG2 e ABCC2) e SLC (SLCO1B1, SLCO2B1 e SLC22A1) foi avaliada por RT-PCRq em células mononucleares d

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28

Al-Khfajy, Wrood Salim Dawood. "Role Of Transmembrane 141 in Cholesterol Metabolism." Kent State University / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=kent1416142859.

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29

Flinois, Thomas. "Modification d'électrodes par des films redox-actifs, des lipides et des transporteurs ioniques membranaires : vers l'élaboration d'une pile biomimétique." Thesis, Rennes 1, 2019. http://www.theses.fr/2019REN1S093.

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En s'inspirant des processus transmembranaires de transport d'ions à l'œuvre dans les cellules vivantes, la conception d'une pile biomimétique peut être envisagée. Le principe de cette pile est d'utiliser les gradients de concentration en ions ou en protons induits par la protéine NhaA, un antiport transmembranaire Na+/2H+, pour générer de l'énergie électrique. Cette thèse contribue à l'élaboration de cette pile à travers des modifications d'électrodes permettant de détecter l'activité de transporteurs ioniques à l'interface électrode / membrane biomimétique. Une revue bibliographique des aspe

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30

Hakizimana, Pierre. "Phosphatidylethanolamine regulates the function and the structure of LmrP, a bacterial multidrug transporter protein associated to antibiotic resistance." Doctoral thesis, Universite Libre de Bruxelles, 2008. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210486.

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The multidrug transporter LmrP, member of the major facilitator superfamily (MFS), confers L. lactis and recombinant E. coli cells resistance to an array of cytotoxic compounds including antibiotics. LmrP mediates drug extrusion from the plasma membrane by an electrogenic proton/drug exchange reaction, whereby a positively charged substrate may move towards the external medium in exchange for two or more protons moving towards the cytoplasm. Recent studies have suggested that MFS transporters require phosphatidylethanolamine (PE) for function and proper topology. However, the specificity of th

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31

Freire, Camilla Camerino Santana Davino. "Metabolismo de lipídeos em inseto coleóptero: digestão e transporte de ácidos graxos." Universidade Federal de Alagoas, 2018. http://www.repositorio.ufal.br/handle/riufal/3421.

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Coleoptera is an order of insects well known as beetles. Most coleopteran species are phytophagous insects and for this reason are essential to crop and storage pests such as the Tribolium castaneum. Lipid metabolism is vital for the biological functions of insects, playing a role in the generation of metabolic energy and other cellular processes. Fatty acid transport proteins (FATPs) play a crucial role in the transport of extracellular fatty acids to cells, have a conserved sequence between species and are involved in the synthesis of hormones and pheromones. Recent studies show that silenci

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Ohlwein, Nina. "Endocytosis controlled by monolayer area asymmetry." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2011. http://dx.doi.org/10.18452/16403.

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Endozytose erfordert hohe Membrankrümmung und führt zu Flächenänderungen der Membranhälften. Dies kann durch eine Oberflächendifferenz zwischen den Schichten initiiert werden, die durch geänderte Lipidzusammensetzungen hervorgerufen werden kann. Daher wurde die Hypothese aufgestellt, dass Lipid-Transporter zu Beginn der Endozytose für veränderte Flächenverhältnisse verantwortlich sind. Um den Einfluss veränderter Flächen auf Endozytose zu untersuchen, wurden die Oberflächenverhältnisse der Membran durch Zugabe von Phospholipiden verändert und anschließend Endozytose gemessen. Abhängig von der

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Karlsson, Emma. "Compositional clues to sources and sinks of terrestrial organic matter transported to the Eurasian Arctic shelf." Doctoral thesis, Stockholms universitet, Institutionen för miljövetenskap och analytisk kemi, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-116876.

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The amount of organic carbon (OC) present in Siberian Arctic permafrost soils is estimated at twice the amount of carbon currently in the atmosphere. The shelf seas of the Arctic Ocean receive large amounts of this terrestrial OC from Eurasian Arctic rivers and from coastal erosion. Degradation of this land-derived material in the sea would result in the production of dissolved carbon dioxide and may then add to the atmospheric carbon dioxide reservoir. Observations from the Siberian Arctic suggest that transfer of carbon from land to the marine environment is accelerating. However, it is not

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Jacquot, Aurore. "Co-expression et caractérisation fonctionnelle d’un transporteur de lipides (une « flippase ») de la levure S. cerevisiae : l’ATPase P4 Drs2p, en complexe avec sa sous-unité associée Cdc50p." Thesis, Paris 11, 2012. http://www.theses.fr/2012PA11T081/document.

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Les membranes plasmiques et les membranes du trans-Golgi des cellules eucaryotes présentent une asymétrie des lipides qui les composent, avec les aminophospholipides (APLs : phosphatidylsérine et phosphatidyléthanolamine) enrichis dans le feuillet cytosolique. La dissipation de cette asymétrie est impliquée dans de nombreux processus (patho)physiologiques. Plusieurs études suggèrent que les ATPases P4 sont les candidats les plus probables pour le transport des APLs et le maintien de leur distribution asymétrique ; leur délétion dans la levure inhibe le trafic membranaire. En outre, des études

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Trotier-Faurion, Alexandra. "Optimisation pharmacologique des dérivés de la créatine pour le traitement du déficit en transporteur de la créatine." Phd thesis, Université Paris Sud - Paris XI, 2013. http://tel.archives-ouvertes.fr/tel-00806976.

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Le déficit en transporteur de la créatine est une maladie rare neurologique dans laquelle la perte de fonctionnalité du transporteur de la créatine (SLC6A8) conduit à une absence de créatine au niveau cérébral et à des retards de développement majeurs chez les enfants. A l'heure actuelle, aucune thérapie efficace n'est disponible.Une approche thérapeutique potentielle est le développement de molécules prodrogues de la créatine plus lipophiles qui franchiront les membranes cellulaires de façon passive et la recherche d'une formulation galénique susceptible d'emmener la prodrogue vers les cellul

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Carswell, Casey. "The Structural Characterization of Two Prokaryotic Membrane Proteins: CfrA and ELIC." Thesis, Université d'Ottawa / University of Ottawa, 2014. http://hdl.handle.net/10393/31214.

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This thesis focuses on the structural and functional characterization of two integral membrane proteins; CfrA, an outer membrane TonB-dependent transporter (TBDT) from Campylobacter jejuni, and ELIC, a pentameric ligand-gated ion channel (pLGIC) from Erwinia Chrysanthemi. The spectroscopic characterization of CfrA revealed a fold consistent with the structural and biophysical properties observed for other TBDT. Both a homology model of CfrA and sequence alignments of CfrA with other ferric-enterobactin transporters suggested a unique mode of ligand binding, thus raising the possibility that

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37

Hardy, Lise. "Identification de nouveaux acteurs du métabolisme des HDL : impact sur les maladies cardiovasculaires Critical role of the human ATP-binding cassette G1 transporter in cardiometabolic diseases A Genome Wide Association Study on plasma FV levels identified PLXDC2 as a new modifier of the coagulation process." Thesis, Sorbonne université, 2019. http://www.theses.fr/2019SORUS546.

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De faibles concentrations de cholestérol associé aux HDL (HDL-C) est un facteur de risque indépendant des maladies cardiovasculaires (MCV). Les HDL sont capables de réaliser de l’efflux de lipides des tissus périphériques pour assurer son retour vers le foie, et ont des rôles athéroprotecteurs. Le travail mené ici vise à identifier de nouveaux acteurs impliqués dans la détermination des fonctions des HDL. Le transporteur ABCG1 réalise de l’efflux de cholestérol, de phospholipides (PL), ou encore de vitamines à partir des macrophages périphériques vers les HDL. Nous avons montré que la stimulat

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Gumí, Audenis Berta. "Structural organization of model membranes: a complementary approach combining atomic force microscopy and X-ray techniques." Doctoral thesis, Universitat de Barcelona, 2018. http://hdl.handle.net/10803/550973.

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Biological membranes (BMs) are self-sealing boundaries, which confine the permeability barriers of cells and organelles and provide the means to compartmentalize functions. Apart from being crucial for the cell structure, they provide a support matrix for all the proteins inserted in the cell, acting as channels to exchange mass, energy and information with the environment. BMs mediate several biological functions, such as trafficking, cell division, endocytosis and exocytosis, demanding strong conformational changes of the lipid membrane like fusion, fission or tubes growth. These mechanical

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Brown, Dustin Paul. "TARGET-DIRECTED BIOSYNTHETIC EVOLUTION: REDIRECTING PLANT EVOLUTION TO GENOMICALLY OPTIMIZE A PLANT’S PHARMACOLOGICAL PROFILE." UKnowledge, 2015. http://uknowledge.uky.edu/neurobio_etds/13.

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The dissertation describes a novel method for plant drug discovery based on mutation and selection of plant cells. Despite the industry focus on chemical synthesis, plants remain a source of potent and complex bioactive metabolites. Many of these have evolved as defensive compounds targeted on key proteins in the CNS of herbivorous insects, for example the insect dopamine transporter (DAT). Because of homology with the human DAT protein some of these metabolites have high abuse potential, but others may be valuable in treating drug dependence. This dissertation redirects the evolution of a nat

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Sigrüner, Alexander [Verfasser]. "ABCA transporters and associated genes in lipid metabolism / vorgelegt von Alexander Sigrüner." 2007. http://d-nb.info/986961256/34.

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Hsiao, Man-Yun, and 蕭蔓妘. "Extraction of membrane lipid rafts from gills of euryhaline fish and salinity effects on abundance of ion transporters in branchial lipid rafts." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/bfwwyh.

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碩士<br>國立中興大學<br>生命科學系所<br>106<br>Lipid rafts are microdomains of the plasma membrane enriched in cholesterol, sphingolipids, glycosphingolipids and proteins (e.g. Flotillin). Lipids in the lipid raft are composed of long-chain saturated fatty acids, which make it insoluble in nonionic detergents. In previous studies on mammalian cells, ion exchanges mainly occurred in lipid rafts. However, in fish, there are few studies on lipid rafts. Therefore, the aim of the present study is to establish the extraction method of lipid rafts in fish gills, and to investigate the localization and protein expr

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Gulati, Sonia. "Characterizing the Interaction of the ATP Binding Cassette Transporters (G subfamily) with the Intracellular Protein Lipid Environment." Thesis, 2011. https://doi.org/10.7916/D8ZW1SW7.

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Cholesterol is an essential molecule that mediates a myriad of critical cellular processes, such as signal transduction in eukaryotes, membrane fluidity, and steroidogenesis. As such it is not surprising that cholesterol homeostasis is tightly regulated, striking a precise balance between endogenous synthesis and regulated uptake/efflux to and from extracellular acceptors. In mammalian cells, sterol efflux is a key component of the homeostatic equation and is mediated by members of the ATP binding cassette (ABC) transporter superfamily. ATP-binding cassette (ABC) transporters represent a gro

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Tan, Kah Poh. "Nuclear Factor (Erythroid 2-like) Factor 2 (Nrf2) as Cellular Protector in Bile Acid and Retinoid Toxicities." Thesis, 2008. http://hdl.handle.net/1807/17287.

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Exposure to toxic bile acids (BA) and retinoic acids (RA) is implicated in toxicities related to excessive oxidative stress. This thesis examined roles and mechanisms of the oxidative stress-responsive nuclear factor (erythroid 2-like) factor 2 (Nrf2) in adaptive cell defense against BA and RA toxicities. Using liver cells and mouse models, many antioxidant proteins known to be Nrf2 target genes, particularly the rate-limiting enzyme for glutathione (GSH) biosynthesis, i.e., glutamate-cysteine ligase subunits (GCLM/GCLC), were induced by BA [lithocholic acid (LCA)] or RA (all-trans, 9-cis an

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Mendes, Maria Manuel Feliciano da Costa. "Lipid nanoparticles as a versatile system for drug administration." Master's thesis, 2016. http://hdl.handle.net/10316/36494.

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Dissertação de mestrado em Tecnologias do Medicamento, apresentada à Faculdade de Farmácia da Universidade de Coimbra<br>A nanotecnologia é uma ciência emergente com aplicação em diferentes áreas, com especial ênfase nas ciências da saúde. As nanopartículas de lipídicas (NL) são um nanosistema promissor para a entrega de fármacos, que suscita interesse particular em comparação com os sistemas coloidais convencionais. A sua natureza biocompatível e biodegradável, a estabilidade físico-química, o controle sobre a libertação do fármaco, relação custo-eficácia e fácil transposição de escala s

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Pandey, Aparamita. "Glucose and Lipid Metabolism during Pregnancy and Lactation in Rats : Role of Undercarboxylated Osteocalcin." Thesis, 2016. http://etd.iisc.ac.in/handle/2005/3074.

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Energy homeostasis is an important physiological mechanism essential for balancingenergy flow through the living systems by managing overall metabolism in the body. Thus, energy homeostasis is under a tight control by means of extremely well-regulated energy metabolism. One of the most common metabolic disorders that occur following disruption in energy homeostasis mechanisms is obesity. Obese individuals develop insulin resistance in the peripheral tissues (fat and muscle) and may also include non-alcoholic fatty liver disease. Insulin resistance is the primary factor responsible for the deve

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Pandey, Aparamita. "Glucose and Lipid Metabolism during Pregnancy and Lactation in Rats : Role of Undercarboxylated Osteocalcin." Thesis, 2016. http://hdl.handle.net/2005/3074.

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Energy homeostasis is an important physiological mechanism essential for balancingenergy flow through the living systems by managing overall metabolism in the body. Thus, energy homeostasis is under a tight control by means of extremely well-regulated energy metabolism. One of the most common metabolic disorders that occur following disruption in energy homeostasis mechanisms is obesity. Obese individuals develop insulin resistance in the peripheral tissues (fat and muscle) and may also include non-alcoholic fatty liver disease. Insulin resistance is the primary factor responsible for the deve

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Chang, Shu-Wen, and 張書聞. "Effects of Collapsing Response Mediator Protein 2 on Glucose Transporter Type 4 Translocation and Lipid Metabolism in Adipocyte Differentiation via Cytoskeleton Dynamics." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/27002176841105689762.

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碩士<br>國立陽明大學<br>醫學生物技術暨檢驗學系<br>104<br>Diabetes mellitus is a metabolic abnormality defined by hyperglycemia resulting from defects in insulin action and/or insulin secretion. Diabetic patients with long-term hyperglycemia are susceptible to develop multiple complications and neurodegenerative diseases due to hyperglycemia-resulted oxidative stress and damage. Cytoskeleton is abnormally assembled and neurotransmission is impaired in neurodegenerative diseases. Moreover, alterations in cytoskeleton dynamics have been implicated in insulin action, glucose transporter type 4 (GLUT4) translocation

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Dagenais, Bellefeuille Steve DB. "Nitrate metabolism in the dinoflagellate Lingulodinium polyedrum." Thèse, 2015. http://hdl.handle.net/1866/15897.

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Les dinoflagellés sont des eucaryotes unicellulaires retrouvés dans la plupart des écosystèmes aquatiques du globe. Ces organismes amènent une contribution substantielle à la production primaire des océans, soit en tant que membre du phytoplancton, soit en tant que symbiontes des anthozoaires formant les récifs coralliens. Malheureusement, ce rôle écologique majeur est souvent négligé face à la capacité de certaines espèces de dinoflagellés à former des fleurs d'eau, parfois d'étendue et de durée spectaculaires. Ces floraisons d'algues, communément appelées "marées rouges", peuvent avoir

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Mok, Leo. "In Vitro Characterization of the Function of ABCA1: Effects of Naturally Occurring Mutations." Thesis, 2010. http://hdl.handle.net/1974/5434.

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The ATP-binding cassette (ABC) transporter, ABCA1, plays a pivotal role in reverse cholesterol transport, which is the elimination of excess sterols from peripheral cells and their transport to the liver for elimination. Early studies failed to detect significant ATPase activity, prompting the suggestion that ABCA1 was an ATP-regulated receptor, rather than an active transporter. We have provided evidence that ABCA1 can bind ATP and trap its hydrolysis product, ADP, in the presence of either ortho-vanadate or beryllium fluoride and Mg2+ or Mn2+. We have also shown that both nucleotide-bindi

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