Academic literature on the topic 'Lipid Vesicle'

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Journal articles on the topic "Lipid Vesicle"

1

McMaster, Christopher R. "Lipid metabolism and vesicle trafficking: More than just greasing the transport machinery." Biochemistry and Cell Biology 79, no. 6 (2001): 681–92. http://dx.doi.org/10.1139/o01-139.

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The movement of lipids from their sites of synthesis to ultimate intracellular destinations must be coordinated with lipid metabolic pathways to ensure overall lipid homeostasis is maintained. Thus, lipids would be predicted to play regulatory roles in the movement of vesicles within cells. Recent work has highlighted how specific lipid metabolic events can affect distinct vesicle trafficking steps and has resulted in our first glimpses of how alterations in lipid metabolism participate in the regulation of intracellular vesicles. Specifically, (i) alterations in sphingolipid metabolism affect
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2

Bar, Laure, George Cordoyiannis, Shova Neupane, Jonathan Goole, Patrick Grosfils, and Patricia Losada-Pérez. "Asymmetric Lipid Transfer between Zwitterionic Vesicles by Nanoviscosity Measurements." Nanomaterials 11, no. 5 (2021): 1087. http://dx.doi.org/10.3390/nano11051087.

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The interest in nano-sized lipid vesicles in nano-biotechnology relies on their use as mimics for endosomes, exosomes, and nanocarriers for drug delivery. The interactions between nanoscale size lipid vesicles and cell membranes involve spontaneous interbilayer lipid transfer by several mechanisms, such as monomer transfer or hemifusion. Experimental approaches toward monitoring lipid transfer between nanoscale-sized vesicles typically consist of transfer assays by fluorescence microscopy requiring the use of labels or calorimetric measurements, which in turn require a large amount of sample.
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3

Salac, David, and Michael J. Miksis. "Reynolds number effects on lipid vesicles." Journal of Fluid Mechanics 711 (August 31, 2012): 122–46. http://dx.doi.org/10.1017/jfm.2012.380.

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AbstractVesicles exposed to the human circulatory system experience a wide range of flows and Reynolds numbers. Previous investigations of vesicles in fluid flow have focused on the Stokes flow regime. In this work the influence of inertia on the dynamics of a vesicle in a shearing flow is investigated using a novel level-set computational method in two dimensions. A detailed analysis of the behaviour of a single vesicle at finite Reynolds number is presented. At low Reynolds numbers the results recover vesicle behaviour previously observed for Stokes flow. At moderate Reynolds numbers the cla
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4

Yu, Haijia, Yinghui Liu, Daniel R. Gulbranson, Alex Paine, Shailendra S. Rathore, and Jingshi Shen. "Extended synaptotagmins are Ca2+-dependent lipid transfer proteins at membrane contact sites." Proceedings of the National Academy of Sciences 113, no. 16 (2016): 4362–67. http://dx.doi.org/10.1073/pnas.1517259113.

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Organelles are in constant communication with each other through exchange of proteins (mediated by trafficking vesicles) and lipids [mediated by both trafficking vesicles and lipid transfer proteins (LTPs)]. It has long been known that vesicle trafficking can be tightly regulated by the second messenger Ca2+, allowing membrane protein transport to be adjusted according to physiological demands. However, it remains unclear whether LTP-mediated lipid transport can also be regulated by Ca2+. In this work, we show that extended synaptotagmins (E-Syts), poorly understood membrane proteins at endopl
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5

Kisak, E., M. Kennedy, and J. A. Zasadzinski. "Self-Limiting Aggregation By Controlled Ligand-Receptor Stoicfflometry and Its Use For a Novel Drug Delivery System." Microscopy and Microanalysis 5, S2 (1999): 1212–13. http://dx.doi.org/10.1017/s1431927600019383.

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Lipid vesicles are used as drug delivery vehicles for the slow sustained release of a drug compound to a specific site in the body. This translates to more efficient medication with limited side effects. Although unilamellar drug delivery vesicles have progressed greatly, they are still limited in there applications. Our group has designed a second generation drug release system, the “vesosome“ which incorporates an aggregate of lipid vesicles encapsulated in a second lipid membrane. The two separate membranes can be specialized to allow for increased drug encapsulation and better control over
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6

Willes, Keith L., Jasmyn R. Genchev, and Walter F. Paxton. "Hybrid Lipid-Polymer Bilayers: pH-Mediated Interactions between Hybrid Vesicles and Glass." Polymers 12, no. 4 (2020): 745. http://dx.doi.org/10.3390/polym12040745.

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One practical approach towards robust and stable biomimetic platforms is to generate hybrid bilayers that incorporate both lipids and block co-polymer amphiphiles. The currently limited number of reports on the interaction of glass surfaces with hybrid lipid and polymer vesicles—DOPC mixed with amphiphilic poly(ethylene oxide-b-butadiene) (PEO-PBd)—describe substantially different conclusions under very similar conditions (i.e., same pH). In this study, we varied vesicle composition and solution pH in order to generate a broader picture of spontaneous hybrid lipid/polymer vesicle interactions
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7

Cummings, Jason E., Donald P. Satchell, Yoshinori Shirafuji, Andre J. Ouellette та T. Kyle Vanderlick. "Electrostatically Controlled Interactions of Mouse Paneth Cell α-Defensins with Phospholipid Membranes". Australian Journal of Chemistry 56, № 10 (2003): 1031. http://dx.doi.org/10.1071/ch03110.

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Antimicrobial peptides of the innate immune systems of many organisms are known to interact with lipid membranes, with electrostatic interactions playing an important role. We have studied the interactions of the mouse α-defensin, cryptdin-4, and its precursor, procryptdin-4, with phospholipid model membranes in the form of vesicles. Both peptides induce ‘graded’ leakage of vesicle contents, however procryptdin-4 exhibits only minimal membrane disruptive activity. Vesicles containing a higher fraction of anionic lipid are more susceptible to peptide-induced leakage. Electrophoretic mobility me
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8

Kamiya, Koki, Toshihisa Osaki, and Shoji Takeuchi. "Formation of vesicles-in-a-vesicle with asymmetric lipid components using a pulsed-jet flow method." RSC Advances 9, no. 52 (2019): 30071–75. http://dx.doi.org/10.1039/c9ra04622d.

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9

Miyamaru, Chiho, Mao Koide, Nana Kato, Shogo Matsubara, and Masahiro Higuchi. "Fabrication of CaCO3-Coated Vesicles by Biomineralization and Their Application as Carriers of Drug Delivery Systems." International Journal of Molecular Sciences 23, no. 2 (2022): 789. http://dx.doi.org/10.3390/ijms23020789.

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We fabricated CaCO3-coated vesicles as drug carriers that release their cargo under a weakly acidic condition. We designed and synthesized a peptide lipid containing the Val-His-Val-Glu-Val-Ser sequence as the hydrophilic part, and with two palmitoyl groups at the N-terminal as the anchor groups of the lipid bilayer membrane. Vesicles embedded with the peptide lipids were prepared. The CaCO3 coating of the vesicle surface was performed by the mineralization induced by the embedded peptide lipid. The peptide lipid produced the mineral source, CO32−, for CaCO3 mineralization through the hydrolys
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10

Cohen, D. E., M. Angelico, and M. C. Carey. "Quasielastic light scattering evidence for vesicular secretion of biliary lipids." American Journal of Physiology-Gastrointestinal and Liver Physiology 257, no. 1 (1989): G1—G8. http://dx.doi.org/10.1152/ajpgi.1989.257.1.g1.

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We employed quasielastic light scattering, negative-stain, and freeze-fracture electron microscopy to study the time-dependent physicochemical behavior of biliary lipids in fresh rat bile. Three to five minutes after bile collection, the earliest light scattering measurements and electron microscopy revealed unilamellar vesicles (mean hydrodynamic radius, Rh = 430-740 A) coexisting with mixed micelles (Rh = 20-120 A) in all biles. Both percent biliary vesicles (1 to greater than 70%) and micellar sizes varied inversely with bile salt concentration (range 1.6-72 mM) both during endogenous pool
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