Relevant bibliographies by topics / Lipide complexe

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Academic literature on the topic 'Lipide complexe'

Author: Grafiati
Published: 4 June 2021
Last updated: 9 February 2022

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Journal articles on the topic "Lipide complexe"

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Houdou, Marine, and François Foulquier. "Anomalies congénitales de la glycosylation (CDG)." médecine/sciences 36, no. 8-9 (August 2020): 735–46. http://dx.doi.org/10.1051/medsci/2020128.

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La glycosylation est un processus cellulaire complexe conduisant à des transferts successifs de monosaccharides sur une molécule acceptrice, le plus souvent une protéine ou un lipide. Ce processus est universel chez tous les organismes vivants et est très conservé au cours de l’évolution. Chez l’homme, des perturbations survenant au cours d’une ou plusieurs réactions de glycosylation sont à l’origine de glycopathologies génétiques rares, appelées anomalies congénitales de la glycosylation ou congenital disorders of glycosylation (CDG). Cette revue propose de revisiter ces CDG, de 1980 à aujourd’hui, en présentant leurs découvertes, leurs diagnostics, leurs causes biochimiques et les traitements actuellement disponibles.
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Ma, Chengye, Yuyan Fan, Shuhua Wu, Zhehao Zhang, and Dongliang Zhang. "Analysis of the Complex Index of Extruded Corn Starch and Degermed Corn." Journal of Food Research 6, no. 6 (October 29, 2017): 56. http://dx.doi.org/10.5539/jfr.v6n6p56.

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Commercial corn starch or degermed corn contains lipids and protein, and starch-lipid (or protein) complexes were formed during extrusion. The formation of starch and lipid (or protein) complexes was investigated using the complex index (CI) and differential scanning calorimetry (DSC) analysis. The CI of extrudates of a commercial corn starch/germ mixture (or gluten meal) showed that starch was complexed with lipid or protein, thus decreasing the iodine-binding capacity of amylose. The CI increased as the content of germ or gluten meal blending starch increased. Blends containing degermed corn and thermostable or mesophilic α-amylase were extruded. The CI of extrudates was higher than 55%; however, the starch-lipid complex was not stable and could be separated. The DSC analysis of the blending starch extrudate and palmitic acid showed that the enthalpy of the starch-palmitic acid complex was increased with increasing fatty acid content. Increased complex formation required more DSC heating, resulting in an enthalpy change of the endothermic peak rise, with the peak temperature higher than 100℃.
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WETZER, Barbara, Gerardo BYK, Marc FREDERIC, Marc AIRIAU, Francis BLANCHE, Bruno PITARD, and Daniel SCHERMAN. "Reducible cationic lipids for gene transfer." Biochemical Journal 356, no. 3 (June 8, 2001): 747–56. http://dx.doi.org/10.1042/bj3560747.

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One of the main challenges of gene therapy remains the increase of gene delivery into eukaryotic cells. We tested whether intracellular DNA release, an essential step for gene transfer, could be facilitated by using reducible cationic DNA-delivery vectors. For this purpose, plasmid DNA was complexed with cationic lipids bearing a disulphide bond. This reduction-sensitive linker is expected to be reduced and cleaved in the reducing milieu of the cytoplasm, thus potentially improving DNA release and consequently transfection. The DNA–disulphide-lipid complexation was monitored by ethidium bromide exclusion, and the size of complexes was determined by dynamic light scattering. It was found that the reduction kinetics of disulphide groups in DNA–lipid complexes depended on the position of the disulphide linker within the lipid molecule. Furthermore, the internal structure of DNA–lipid particles was examined by small-angle X-ray scattering before and after lipid reduction. DNA release from lipid complexes was observed after the reduction of disulphide bonds of several lipids. Cell-transfection experiments suggested that complexes formed with selected reducible lipids resulted in up to 1000-fold higher reporter-gene activity, when compared with their analogues without disulphide bonds. In conclusion, reduction-sensitive groups introduced into cationic lipid backbones potentially allow enhanced DNA release from DNA–lipid complexes after intracellular reduction and represent a tool for improved vectorization.
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Guo, Wenjin, and Robert J. Lee. "Efficient Gene Delivery Using Anionic Liposome-Complexed Polyplexes (LPDII)." Bioscience Reports 20, no. 5 (October 1, 2000): 419–32. http://dx.doi.org/10.1023/a:1010338219401.

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Synthetic gene transfer vectors based on polyplexes complexed to anionic liposomes (LPDII vectors) were characterized for their transfection efficiency in cultured mammalian cells. The effects of polycation to DNA ratio, lipid to DNA ratio, choice of polycation and lipid composition were systematically evaluated in human oral carcinoma KB cells, using a luciferase reporter gene. For LPDII formulations containing poly-L-lysine and dioeoylphosphatidylethanolamine/cholesteryl hemisuccinate (DOPE/CHEMS) anionic liposomes, at a constant lipid to DNA ratio, an increase in the polycation/DNA (N/P) ratio resulted in an increase in transfection activity. Meanwhile, the optimal lipid to DNA ratio for efficient gene delivery was influenced by the N/P ratio used, and was increased at higher N/P ratios. For the DNA condensing agent, poly-L-lysine could be replaced by polyethylenimine (PEI) as the DNA condensing agent in the formulations. For the lipidic components, CHEMS could be replaced by other anioniclipids including oleic acid, dicetylphosphate and phosphatidylserine, but DOPE, a fusogenic helper lipid, could not be replaced by dioleolyphosphatidylcholine. LPDII formulation showed significantly less cytotoxicity compared to the commonly used cationic lipsomes or PEI mediated transfection and several cell lines were transfected with high efficiency. LPDII vectors avoid the use of toxic cationic lipids and may have potential application in gene therapy.
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Krupa, Zbigniew. "Acyl lipids in the supramolecular chlorophyll-protein complexes of photosystems - isolation artifacts or integral components regulating their structure and functions?" Acta Societatis Botanicorum Poloniae 57, no. 3 (2014): 401–18. http://dx.doi.org/10.5586/asbp.1988.039.

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The precise nature of interactions between the chloropnyll-protein complexes related to photosystem I or photosystem II and the acyl lipids in the thylakoid membranes is not yet fully elucidated. Analyses of the lipid content of isolated photosystem supramolecular complexes reveal that they are integral components of these complexes. However, the relations between certain acyl lipids and the specific structure and functions of the complexes investigated are still widely discussed. The most generally accepted phenomenon is the fact of participation of phosphatidylglycerol containing the unique <em>trans-</em>Δ<sup>3</sup> -hexadecenoic acid in the oligomerization of the light-harvesting chlorophyll a/b protein complex II.
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Falcão, Mário Cícero. "Dinâmica da composição lipídica das fórmulas infantis e suas implicações clínicas." Braspen Journal 35, no. 3 (October 15, 2020): 294–306. http://dx.doi.org/10.37111/braspenj.2020353015.

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In human milk, the role of lipids as a source for the adequate growth and development of the infant is highlighted. The lipidic system of breast milk, responsible for approximately 50% of calories, is structured for the newborn and the infant. Digestion and absorption of lipids are facilitated by the organization of fat, the type of fatty acid (palmitic, oleic, linoleic, linolenic acids, etc.), the composition of triglycerides and the lipase stimulated by bile salts. In addition, milk contains docosahexaenoic acid, which allows optimal neurological and immunological development. Although the lipid structure of breast milk is extremely complex, it should serve as a model for the dynamics of the lipid composition of infant formulas. The addition of long-chain fatty acids (arachidonic and docosahexaenoic acids) linked to phospholipids in infant formulas can contribute to a better development of infants, as well as acting on the immune system and metabolic imprinting, reducing the risk of chronic non-communicable diseases. Infants receiving formulas with palmitic acid in theß-2 position have a higher lactobacillus count in the feces, when compared to those receiving formulas with palmitic acid in the ß-1 and ß-3 positions, promoting the maintenance of intestinal eubiosis. Infants receiving formulas with ß-2 palmitic acid present bone health similar to infants breastfeeding, as fecal calcium loss does not occur.
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Kushnerova, Natalya F., Yury A. Rakhmanin, Tatiana V. Momot, Rufina I. Mikhailova, Irina N. Ryzhova, Svetlana E. Fomenko, Vladimir G. Sprygin, et al. "Assessment of changes in blood plasma biochemical indices at hypercholesterol diet with a high fat load." Hygiene and sanitation 100, no. 6 (June 28, 2021): 617–22. http://dx.doi.org/10.47470/0016-9900-2021-100-6-617-622.

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Introduction. It was studied the lipid composition of the blood plasma of rats under the impact of a hyper cholesterol diet with a high fat load. It was carried out the prevention of disturbances in blood plasma biochemical parameters with a lipid complex from the tunic of the marine hydrobiont Halocynthia aurantium. Materials and methods. The experiment was carried outwith outbred male rats weighing 200 ± 3 g.The experimental model of a hyper cholesterol diet with a high fat load with the development of dyslipidemia was set up by feeding the animals with ahigh fat diet consisting of 2% cholesterol and 20% beef fat from the total diet. The animals were divided into the following groups of 10 rats each: group 1 - control (standard diet), group 2 - dyslipidemia (hypercholesterol diet with high fat load), group 3 - dyslipidemia + lipid complex from ascidia. Results. It was shown that the influence of the diet was accompanied by an increase in the amount of total lipids in the blood plasma of rats, cholesterol, low-density lipoproteins (LDL), as well as a decrease in total phospholipids and high-density lipoproteins (HDL), which is considered as an indicator of the formation of dyslipidemia. The contents of phospholipid lysofractions increased due to the activation of phospholipases. The amount of fatty acid esters and cholesterol esters decreased, which indicates the inhibition of esterification processes. The imbalance in the phospholipid spectrum of blood plasma occurred: the amount of metabolically active fractions required for the functioning of membrane-bound enzymes decreased. The addition of a lipid complex from the tunic of ascidian purple into the diet was accompanied by a pronounced prophylactic effect, which manifested itself in the normalization of the studied biochemical parameters. The lipid complex containing a wide range of “sea” phospholipids and polynonsaturated fatty acids of the n-3 type is an important basis for application as prophylactic in the conditions of a hypercholesterol diet with a high-fat load. Conclusion. Application of the lipidic complexes containing the “sea” lipids allocated from a tunic of the ascidian purple can be useful and perspective at a dislipidemiya and a hypercholesterolemia that will allow to carry out effective prevention of violations of metabolic reactions at influence of hyper high-calorie food.
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Cuevas-Zuviría, Bruno, Marina Mínguez-Toral, Araceli Díaz-Perales, María Garrido-Arandia, and Luis F. Pacios. "Structural Dynamics of the Lipid Antigen-Binding Site of CD1d Protein." Biomolecules 10, no. 4 (April 1, 2020): 532. http://dx.doi.org/10.3390/biom10040532.

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CD1 molecules present lipid antigens to T-cells in early stages of immune responses. Whereas CD1‒lipid‒T-cell receptors interactions are reasonably understood, molecular details on initial trafficking and loading of lipids onto CD1 proteins are less complete. We present a molecular dynamics (MD) study of human CD1d, the isotype that activates iNKT cells. MD simulations and calculations of properties and Poisson-Boltzmann electrostatic potentials were used to explore the dynamics of the antigen-binding domain of the apo-form, CD1d complexes with three lipid–antigens that activate iNKT cells and CD1d complex with GM2AP, a protein that assists lipid loading onto CD1 molecules in endosomes/lysosomes. The study was done at pH 7 and 4.5, values representative of strongly acidic environments in endosomal compartments. Our findings revealed dynamic features of the entrance to the hydrophobic channels of CD1d modulated by two α helices with sensitivity to the type of lipid. We also found lipid- and pH-dependent dynamic changes in three exposed tryptophans unique to CD1d among the five human CD1 isotypes. On the basis of modelled structures, our data also revealed external effects produced by the helper protein GM2AP only when it interacts in its open form, thus suggesting that the own assistant protein also adapts conformation to association with CD1d.
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Sarwal, Rashmi, S. N. Sanyal, and S. Khera. "Lipid metabolism inTrichuris globulosa(Nematoda)." Journal of Helminthology 63, no. 4 (December 1989): 287–97. http://dx.doi.org/10.1017/s0022149x00009160.

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ABSTRACTAdult males and females ofTrichuris globulosa, an intestinal nematode parasite of goats, were studied for their lipid composition, capability of incorporation of (Na)-1-14C-acetate into different lipid classes and the activity of certain key enzymes of lipid metabolism. The parasite possesses a large variety of lipids including certain complex lipids. These are phosphatidylcholine (PC), diphosphatidylglycerol (cardiolipin), lysophosphatidylcholine (LPC), lysophosphatidylethanolamine (LPE), phosphatidylserine (PS), phosphatidylinositol (PI), plasmalogens (choline+ethanolamine), mono-, di- and triacylglycerols, free and esterified cholesterol, non-esterified fatty acids (NEFA), gangliosides, cerebrosides (glycosyl ceramide) and sulphuric acid esters of cerebrosides (sulphatides). The females contain more lipids than males, particularly the acylglycerols and phospholipids, possibly to meet the energy requirement and structural entities for the daily production of large numbers of eggs. Incorporation studies of labelled substrate, sodium-1-14C acetate demonstrate that the adult female has extremely active mechanisms for biosynthesizing these lipids. Most of the labels are found in PC, PE, SM, acylglycerols, NEFA, gangliosides, cerebrosides and sulphatides. Cholesterol, although a minor component of the parasitic lipids, incorporates large amount of label and also undergoes fast turnover. Kinetic analysis of the incorporation by measuring the rate constant (k) and half life (t½) reveals that gangliosides are the fastest biosynthesizing and turning over lipids, although they constitute only 0·1% of the total lipids. The presence of important enzymes of lipid biosynthesis, glucose-6-phosphate dehydrogenase, malate dehydrogenase and hydroxymethyl glutaryl-CoA reductase and an enzyme of lipid ester hydrolysis, triacylglycerol lipase, is also established inT. globulosa. Michaelis-Menten kinetic characteristics of the parasitic enzymes (Km, Vmax, v and the first order rate constant, k) are comparable with those of rat liver homogenates.
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Grassi, Sara, Paola Giussani, Laura Mauri, Simona Prioni, Sandro Sonnino, and Alessandro Prinetti. "Lipid rafts and neurodegeneration: structural and functional roles in physiologic aging and neurodegenerative diseases." Journal of Lipid Research 61, no. 5 (December 23, 2019): 636–54. http://dx.doi.org/10.1194/jlr.tr119000427.

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Lipid rafts are small, dynamic membrane areas characterized by the clustering of selected membrane lipids as the result of the spontaneous separation of glycolipids, sphingolipids, and cholesterol in a liquid-ordered phase. The exact dynamics underlying phase separation of membrane lipids in the complex biological membranes are still not fully understood. Nevertheless, alterations in the membrane lipid composition affect the lateral organization of molecules belonging to lipid rafts. Neural lipid rafts are found in brain cells, including neurons, astrocytes, and microglia, and are characterized by a high enrichment of specific lipids depending on the cell type. These lipid rafts seem to organize and determine the function of multiprotein complexes involved in several aspects of signal transduction, thus regulating the homeostasis of the brain. The progressive decline of brain performance along with physiological aging is at least in part associated with alterations in the composition and structure of neural lipid rafts. In addition, neurodegenerative conditions, such as lysosomal storage disorders, multiple sclerosis, and Parkinson’s, Huntington’s, and Alzheimer’s diseases, are frequently characterized by dysregulated lipid metabolism, which in turn affects the structure of lipid rafts. Several events underlying the pathogenesis of these diseases appear to depend on the altered composition of lipid rafts. Thus, the structure and function of lipid rafts play a central role in the pathogenesis of many common neurodegenerative diseases.
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Dissertations / Theses on the topic "Lipide complexe"

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Stroebel, David. "Détermination structurale du complexe du cytochrome b6f par cristallographie aux rayons X." Paris 7, 2004. http://www.theses.fr/2004PA077228.

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Yassine, Wissam. "Etude structurale des protéines SNAREs dans le complexe protéine-lipide impliqué dans la fusion membranaire lors du processus d'exocytose." Bordeaux 1, 2008. http://www.theses.fr/2008BOR13767.

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La structure des protéines SNAREs (VAMP1 et Syntaxine1A) et de leur domaines trans- et juxtamembranaires (VAMP22, Syn23 et Syn27 respectivement) a été étudiée dans des membranes lipidiques modèles. Nous avons fait varier la concentration peptidique et la composition lipidique afin de déterminer les paramètres contrôlant l’activité de ces molécules dans la membrane durant la fusion. L’étude tructurale (IR et CD) des peptides VAMP22 et Syn23 ont montré une transition structurale dépendante de la concentration, entre un feuillet béta à forte concentration et une hélice alpha à faible concentration. Cette transition était réversible pour le peptide VAMP22 uniquement. Des perturbations de la membrane lipidique ont été observées suite à ce changement de structure. Les analyses structurales en PM-IRRAS de la protéine VAMP1 seule ou dans un film lipidique neutre (DMPC) a montré une transition structurale réversible entre une hélice alpha et un feuillet béta en fonction de la compression. Dans un film lipidique chargé du DMPG, cette transition n’a pas été observée. Cela laisse suggérer une influence des charges membranaires sur l’organisation de cette protéine. En parallèle, la protéine Syntaxine1A a montré une structure secondaire stable en hélice alpha, indépendamment de la composition lipidique de la membrane. L’addition de quatre résidus juxtamembranaires au peptide Syn23 était associée à une nouvelle organisation structurale du domaine transmembranaire. L’étude structurale associée à l’étude cinétique de fusion ou d’agrégation des peptido-liposomes du peptide Syn 27, permettent de suggérer un éventuel lien entre la structure et la fonction de ce peptide dans la membrane
The structure of SNARE proteins (VAMP1 & Syntaxine1A) and of their trans- and juxtamembrane domains (respectively VAMP22, Syn23 & Syn27) was investigated in synthetic lipid membranes. Different protein concentrations and lipid compositions were used in this study. VAMP22 and Syn23 peptides were studied in IR and CD. A structural transition between an alpha helix and a beta sheet was observed depending on peptide concentration. This transition was reversible only for VAMP22. Membrane Lipid phase was disturbed upon this structural evolution. PM-IRRAS data of pure full length VAMP1 protein film and mixed DMPC/VAMP1 film showed a dynamic behavior of this protein on the interface with a reversible structural transition upon surface compression/decompression cycles. Negatively charged lipid membranes (DMPG, DMPG/DMPC) prohibited this protein from changing structure under same conditions. Syntaxine1A protein subjected to a similar analysis showed no consequences of lipid composition or surface pressure on the structure of the originally alpha helix structured protein. Addition of four juxtamembrane residues to the Syn23 peptide produced modifications within the structural organization of this transmembrane peptide in model membranes. This larger peptide facilitated vesicles membranes fusion when organized as beta sheet
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Benslimane, Chouki. "Étude physiologique de Streptomyces ambofaciens producteur de la spiramycine en milieu complexe : effet de la source de carbone sur la consommation des acides aminés et des acylglycérols." Vandoeuvre-les-Nancy, INPL, 1996. http://www.theses.fr/1996INPL126N.

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L’amélioration rationnelle des procédés de fermentation passe par une meilleure compréhension de la physiologie des micro-organismes d'intérêt industriel. L’étude physiologique de Streptomyces ambofaciens producteur de la spiramycine, un macrolide à 16 membres, est largement étudiée en milieux synthétiques. L’utilisation de milieux très complexes, de type industriel et de composition souvent variable, limite ces études physiologiques dans ces conditions. Pour mieux comprendre le comportement cinétique de ce micro-organisme dans de tels milieux, nous avons abordé une étude du métabolisme initial des acides aminés, des lipides (acylglycérols) et de leur interactions dans des milieux complexes de type industriel contenant comme principaux substrats, des dextrines, de l'extrait de levure et de l'huile de maïs. Des études préliminaires en fioles d'erlenmeyer ont permis de maitriser les conditions permettant une reproductibilité des fermentations et une production de spiramycine satisfaisantes. Les interactions entre les principaux substrats du milieu de culture et leur incidence sur la production de spiramycine ont été étudiées. La présence de dextrines réduit les activités lipolytiques et protéolytiques, l'assimilation des acylglycérols, des acides gras libres à longues chaines, de certains acides aminés et la production de spiramycine. L’évolution des flux initiaux des différents substrats au cours des croissances est présentée. L’évolution de la constitution et de la mobilisation des réserves énergétiques (glycogène, tréhalose, lipides totaux et triacylglyérols) est analysée. Des hypothèses expliquant les relations entre composition en lipides de S. Ambofaciens, transport des acides aminés et production de spiramycine sont proposées
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Teixeira, da Silva Emerson Rodrigo. "Structure and dynamics of DNA confined in-between non-cationic lipid membranes." Thesis, Bordeaux 1, 2011. http://www.theses.fr/2011BOR14342/document.

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Une étude expérimentale sur la structure et la dynamique d'un complexe hydraté de fragments d'ADN (150 pb) et des phases lamellaires de lipides non-cationiques est présentée. Par la variation de d'hydratation, il est possible de contrôler le confinement imposé par cette matrice hôte sur les nucléotides insérés dans les couches aqueuses. L’organisation supramoléculaire du complexe est suivie par diffraction des rayons-X et des techniques de microscopie optique et électronique. Un riche polymorphisme de mésophases est observé en fonction du confinement. Dans le régime plus hydraté, les fragments se distribuent selon une orientation nématique. Dans la mesure où la quantité de l'eau diminue, le confinement des bicouches sur les nucléotides monte et des corrélations trans-membranaires donnent origine à des phases hautement organisées, avec de symétries rectangulaires et hexagonales (2D) d'ADN dans la phase lipidique. L'incorporation totale des nucléotides par la phase lamellaire est observée uniquement lorsque des grandes quantités d'ADN y sont présentes. Ce fait souligne une importance majeur des interactions de volume exclu. Une analyse du paramètre de Caillé montre que l'insertion des fragments diminue les fluctuations des membranes. À partir des ces observations, il est suggéré que la modification des interactions stériques entre des lamelles, associée à des effets interfaciaux ADN-membranes, est un mécanisme important dans le comportement de phases. Les propriétés dynamiques sont étudiés avec la technique de retour de fluorescence après photo-blanchiment (FRAP). Un modèle développé récemment pour l'analyse de diffusion anisotrope est testé avec succès, démontrant une corrélation proche entre structure et dynamique
An experimental study on the structural and dynamical properties of a hydrated DNA-non-cationic complex is presented. By varying the water amount, it is possible to control the confinement imposed by this host matrix over the organization of the nucleotides inserted within the water layers. The supramolecular assembly is investigated by X-rays diffraction and techniques involving both optical and electron microscopy. A rich polymorphism of mesophases is observed in function of confinement. In the more hydrated regime, the fragments are distributed according to nematic orientation in-between lamellae. As the water amount decreases, the confinement of bilayers over the particles increases and transmembrane correlations appear, giving raise to highly-ordered phases, with 2D-rectangular and -hexagonal symmetries of DNA embodied in the lamellar phase. The full incorporation of nucleotides by the lamellar phase is observed only in the presence of large amounts of DNA. This finding points to major importance of excluded volume interactions. An analysis of the Caillé parameter shows that the insertion of DNA reduces the fluctuations of membranes. From these observations, it is suggested that changes in the interactions between bilayers, together with the appearance of interfacial effects between DNA and membranes, are a mechanism relevant for the phase behavior of these systems. The dynamical properties of nucleotides are investigated through the fluorescence recovery after photobleach (FRAP). A model recently developed for analyses of anisotropic diffusion is sucessfully tested, demonstrating a close relationship between structure and dynamics
Um estudo experimental sobre aspectos estruturais e dinâmicos de um complexo hidratado de fragmentos de DNA (150 pb) e fases lamelares de lipídios não-catiônicos é apresentado. Variando-se a hidratação, é possível controlar o confinamento imposto por essa matriz hospedeira sobre os nucleotídeos inseridos na camada aquosa. O arranjo supramolecular do complexo é investigado por difração de raios X e técnicas de microscopia óptica e eletrônica. Um rico polimorfismo de mesofases é observado em função do confinamento. No regime mais hidratado, os fragmentos se distribuem segundo uma orientação nemática entre as membranas. À medida que a quantidade de água diminui, o confinamento das bicamadas sobre os nucleotídeos aumenta e correlações transmembranares aparecem, dando origem a fases altamente organizadas, com simetrias retangulares e hexagonais 2D de DNA entre as lamelas. A incorporação completa de nucleotídeos é observada apenas quando grandes quantidades de DNA estão presentes. Esse fato aponta para importância maior de interações de volume excluído. Uma análise do parâmetro de Caillé mostra que as flutuações das membranas diminuem com a inserção de DNA. A partir dessas observações, é sugerido que a alteração das interações entre membranas, aliada à aparição de efeitos interfaciais entre DNA e membranas, é um mecanismo relevante no comportamento de fase. As propriedades dinâmicas dos nucleotídeos são investigadas através da técnica de FRAP (fluorescence recovery after photobleaching). Um modelo recentemente desenvolvido para análise de difusão anisotrópica é testado com sucesso, demonstrando estreita correlação entre estrutura e dinâmica
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El, Fartah Habsaoui Souad. "Détection du traitement ionisant de denrées alimentaires : étude de la fraction volatile d'une matrice alimentaire riche en lipide : application d'autres techniques (RPE & TL) à la détection d'une matrice complexe." Aix-Marseille 3, 2001. http://www.theses.fr/2001AIX30013.

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Le traitement ionisant est un procédé qui permet d'assainir et d'augmenter la durée de conservation des aliments. Afin d'apporter la preuve que ce traitement a été appliqué ou non, il est nécessaire de disposer de méthodes simples de détection de l'ionisation. Notre travail de thèse a porté sur l'utilisation de trois méthodes : La chromatographie en phase gazeuse couplée à un espace de tête dynamique (CPG-DCI), la résonance paramagnétique électronique (RPE) et la thermoluminescence (TL). Dans un premier temps, nous avons étudié la fraction volatile de la matrice lipidique du jaune d'œuf en utilisant la CPG-DCI. Nous avons mis au point une technique fiable d'identification des nombreux pics chromatographiques ; nous avons ensuite étudié le mécanisme de radiolyse, puis comparé l'effet de l'ionisation sur deux matrices : - Lipides "purs " extraits du jaune d'œuf liquide, (matrice El) - Jaune d'œuf ionisé et dont les lipides ont été extraits après ionisation, (matrice 01) Les différences observées entre les deux matrices peuvent s'expliquer par l'absence de la vitamine E dans la matrice El. Nous avons donc étudié l'effet de la vitamine E sur les mécanismes de radiolyse des lipides du jaune d'œuf. .
Irradiation is a treatment increasing hygienic quality and time storage of foodstuffs. It is necessary to have simple methods of detection to prove whether this treatment was applied or not. We used three methods: gas chromatography coupled with a dynamic head space (GC-DCI), electron spin resonance (ESR) and thermoluminescence (TL). At first, we studied the volatile fraction on egg lipid matrix by using the GC-DCI. We then studied the radiolysis mechanism of yolk egg, and compared the effect of ionisation of lipids before (01) and after (El) their extraction from egg. The observed differences between 01 and El were explained by the absence of vitamin E in the second matrix. We studied the effect of vitamin E on the radiolysis mechanism
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Papadopoulos, Dimitrios. "Synthèses d'analogues de lécithines : caractérisations physico-chimiques et biologiques." Nancy 1, 1996. http://www.theses.fr/1996NAN10323.

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La préparation des composés mimes de la structure des phosphatidylcholines (lécithines), en remplaçant les deux fonctions ester par des liaisons de type amide et une des chaînes grasses hydrogénées par une chaîne fluorée, est l'objectif de ce travail. Les amides, moins facilement hydrolysables que les esters, et les chaînes fluorées peuvent apporter des qualités originales et intéressantes pour une éventuelle utilisation dans divers domaines dont le domaine biomédical. La conception de ces mimes est basée sur le principe de la synthèse modulaire. L'acide 3-hydroxy-2-hydroxyméthyl-2-méthylpropionique est utilisé pour remplacer le glycérol dans son rôle de molécule pivot entre les chaînes hydrophobes et la tête polaire. Une première liaison amide s'effectue avec une amine grasse hydrogénée ou fluorée. L'activation sélective d'une des deux fonctions alcool restantes sur la molécule pivot permet sa substitution par le groupe azide (N3). La réduction de l'azide en amine primaire offre le substrat pour la formation d'une deuxième liaison amide, par couplage avec un acide gras hydrogéné ou fluoré. Les diamides, ainsi formés, hydrogénés ou mixtes sont des structures analogues des "céramides". L'addition du groupe "phosphocholine" sur les analogues céramides s'avère difficile, probablement à cause de la présence des groupes amides. Une autre stratégie de synthèse est adoptée et la phosphorylation se fait avant la réduction du groupe azide. Celui-ci apporte un renfort à la nucléophilie de l'alcool. Ainsi le 2- bromoéthyldichlorophosphate -précurseur du groupement phosphocholinique- se greffe sur les β-amido-γ-azido-alcools avec des rendements corrects. Après hydrolyse de la liaison P-Cl restante et le traitement du diester phosphorique bromé par la triméthylamine, les azido-Iysolécithines analogues ont été récupérées. La réduction de l'azide produit les amino-Iysolécithines. Sur ces dernières un acide gras, hydrogéné ou fluoré, est couplé. Des composés, hydrogénés et mixtes, mimes des lécithines sont ainsi préparés. L'étude physico-chimique des produits synthétisés montre que les azido- et les amino-lysolécithines ont des propriétés de surface analogues à celles des produits naturels. Par contre les composés mixtes ont un comportement, tant en activité de surface qu'en ce qui concerne l'apparition de phases en présence d'eau, relativement original. Ces composés se révèlent toxiques vis-à-vis des cellules malignes (U937). Leur toxicité se manifeste par apoptose, à des concentrations inférieures à 2 10-⁴ M, et par nécrose au delà de cette concentration. En outre, les produits fluorés présentent des taux d'apoptose plus importants que leurs analogues hydrogénés à concentration équivalente. Les résultats physico-chimiques et biologiques encouragent à poursuivre des études plus complètes à propos de ces molécules.
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Mekhalfi, Malika. "Production de lipides et étude de la régulation métabolique chez la diatomée Asterionella formosa." Thesis, Aix-Marseille, 2014. http://www.theses.fr/2014AIXM4770.

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La diatomée d'eau douce A. formosa peut produire des lipides neutres en plus ou moins grandes quantités en fonction des conditions de culture. Ainsi, nous avons montré par exemple qu'une carence en silice stimule la production de triacylglycérols (TAGs) mais génère une diminution de la biomasse. En revanche, nous avons montré que l'addition de bicarbonate et de phytohormones augmente à la fois la biomasse et la production de TAGs. L'ajout de phytohormones dans les milieux de culture de cette diatomée résulte en une augmentation de l'activité d'enzymes dans les extraits et notamment celles du cycle de Benson-Calvin. Parmi ces enzymes, la GAPDH est une enzyme dont l'activité augmente significativement. Nous avons montré que chez A. formosa, cette enzyme forme un complexe ternaire avec la CP12 et la Férrédoxine NADP Réductase (FNR) et non pas avec la CP12 et la phosphoribulokinase comme chez la plupart des organismes photosynthétiques. La régulation de cette enzyme en est de fait modifiée. La phytohormone, 24-épibrassinolide conduit à une augmentation d'activité de la GAPDH qui résulte de la dissociation du complexe GAPDH-CP12 et la GAPDH n'est plus redox régulée. La GAPDH chez les diatomées est donc régulée par des interactions protéineprotéine
A. formosa, a freshwater diatom, can produce different amounts of neutral lipids such as triacylglycerols (TAGs) under different growth conditions. We showed that as it is well-known for diatoms, starvation for silica increased the production of TAGs but decreased biomass. However, the addition of bicarbonate or phytohormones into the growth medium increased both biomass and TAGs. Addition of phytohormones increased the activities of enzymes in particular those of the Benson-Calvin cycle. Among the target enzymes of the Benson-Calvin cycle, GAPDH was strongly affected. We purified this enzyme and demonstrated that, in the diatom A. formosa, glyceraldehyde-3-phosphate dehydrogenase (GAPDH) from the Calvin cycle, forms a complex with the small chloroplast protein CP12 and Ferredoxin NADP Reductase (FNR), which is involved in the photochemical phase of photosynthesis. In cells treated with the phytohormone, 24-epibrassinolide, GAPDH was "free", not redox-regulated and not associated anymore with CP12. Therefore GAPDH from this diatom is regulated by protein-protein interaction but the GAPDH/CP12/FNR complex replaces the one formed between GAPDH, CP12 and phosphoribulokinase found in most photoautotrophs
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Punyamoonwongsa, Patchara. "Synthetic analogues of protein-lipid complexes." Thesis, Aston University, 2007. http://publications.aston.ac.uk/9803/.

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Hypercoiling poly(styrene-alt-maleic anhydride) (PSMA) is known to undergo conformational transition in response to environmental stimuli. The association of PSMA with lipid 2-dilauryl-sn-glycero-3-phosphocholine (DLPC) produces polymer-lipid complex analogues to lipoprotein assemblies found in lung surfactant. These complexes represent a new bio-mimetic delivery vehicle with applications in the cosmetic and pharmaceutical industries. The primary aim of this study was to develop a better understanding of PSMA-DLPC association by using physical and spectroscopic techniques. Ternary phase diagrams were constructed to examine the effects of various factors, such as molecular weight, pH and temperature on PSMA-DLPC association. 31P-NMR spectroscopy was used to investigate the polymorphic changes of DLPC upon associating with PSMA. The Langmuir Trough technique and surface tension measurement were used to explore the association behaviour of PSMA both at the interface and in the bulk of solution, as well as its interaction with DLPC membranes. The ultimate aim of this study was to investigate the potential use of PSMA-DLPC complexes to improve the bioavailability and therapeutic efficacy of a range of drugs. Typical compounds of ophthalmic interest range from new drugs such as Pirenzepine, which has attracted clinical interest for the control of myopia progression, to the well-established family of non-steroid anti-inflammatory drugs. These drugs have widely differing structures, sizes, solubility profiles and pH-sensitivities. In order to understand the ways in which these characteristics influence incorporation and release behaviour, the marker molecules Rhodamine B and Oil Red O were chosen. PSMA-DLPC complexes, incorporated with marker molecules and Pirenzepine, were encapsulated in hydrogels of the types used for soft contact lenses. Release studies were conducted to examine if this smart drug delivery system can retain such compounds and deliver them at a slow rate over a prolonged period of time.
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Mias-Lucquin, Dominique. "Dynamique et mécanique de complexes dystrophine-actine-lipides membranaires." Thesis, Rennes 1, 2018. http://www.theses.fr/2018REN1B024/document.

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La dystrophine est une protéine filamenteuse qui contribue à la structuration des cellules musculaires en créant un lien entre le cytosquelette et le sarcolemme. Avec l’actine du cytosquelette et les lipides membranaires, la dystrophine représente l’un des éléments d’un complexe macromoléculaire, localisé sous la membrane plasmique, dont le rôle est la prévention des dommages qui pourraient être induits à force de contractions-relâchements répétés. De tels dommages, notamment des ruptures du sarcolemme, sont observés chez des personnes atteintes de myopathies de Duchenne (DMD) et de Becker (BMD), des maladies causées par des mutations qui altèrent l’expression ou la fonction de la dystrophine. Ces myopathies sont actuellement incurables et une connaissance approfondie de la relation structure-fonction de la dystrophine et de ses interactions avec ses partenaires s’avère absolument nécessaire à la mise au point de nouvelles stratégies de thérapies géniques. Cette protéine se compose de quatre domaines fonctionnels, dont un domaine central filamentaire, constitué de 24 répétitions successives d’un même motif structural, un faisceau de trois hélices alpha ou « coiled-coil ». Or, il a été récemment montré que la structure de ce domaine central n’est pas strictement linéaire et que certaines régions inter-répétitions (linker) forment des coudes, délimitant ainsi des sous-domaines d’interaction spécifiques. Cette thèse a pour objectif de comprendre l’origine de cette diversité de conformations inter-répétition dans un domaine structuralement homogène, et d’explorer comment elle permet à certaines régions de se différencier afin d’interagir avec l’actine et/ou les lipides membranaires
Dystrophin is a filamentous protein involved in muscular cells structure which links the cytoskeleton to the sarcolemma. Together with cytoskeletal actin and membrane lipids, dystrophin is a part of a macromolecular complex, located under the sarcolemma, which prevents damages induced during repeated muscle contractions and relaxations. Such damages, including sarcolemma disruption, are found in people with Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD), diseases caused by mutations altering dystrophin expression or function. There is currently no treatment to cure these myopathies, and a deep understanding of the structure-function of the dystrophin and its interactions with its partners is necessary to the development of gene therapy strategies. Structuraly, this protein is composed of four functionnal domains, including a long filamentous central domain, composed of 24 successive coiled-coil repeats. It was recently showed that the central domain is not rod shaped and some inter-repeats regions (linker) are kinked, delimiting specific interaction sub-domains. This thesis aims to bring knowledge about the basis of the conformationnal diversity of linkers in a structuraly homogenous domain in human dystrophin. We explore how dystrophin delimits some regions that interact with f-actin and/or membrane lipids
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Weissglas, Daphna. "Gene identification for complex cardiovascular lipid traits." Diss., Restricted to subscribing institutions, 2009. http://proquest.umi.com/pqdweb?did=1875374471&sid=1&Fmt=2&clientId=1564&RQT=309&VName=PQD.

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Books on the topic "Lipide complexe"

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Lewis, Harrison, ed. The complete fats & oils book: Howto buy, use, and control fats & oils. Garden City Park, N.Y: Avery Publishing Group, 1996.

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Harrison, Lewis. The complete fats & oils book: How to buy, use, and control fats & oils. Garden City Park, N.Y: Avery Publishing Group, 1996.

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Erasmus, Udo. Fats that heal, fats that kill: The complete guide to fats, oils, cholesterol, and human health. Burnaby, BC, Canada: Alive Books, 1993.

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Lamari, Foudil, and Jean-Marie Saudubray. Disorders of Complex Lipids Synthesis and Remodeling. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199972135.003.0066.

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Defective lipid catabolic pathways are involved in numerous inherited metabolic diseases such as lysosomal storage diseases and peroxisome biogenesis disorders. We recently described a new classification of a rapidly growing group of inherited metabolic disorders involving biosynthesis and remodeling of complex lipids including phospholipids and sphingolipids. The remarkable progress achieved over the last decade in high throughput gene sequencing and in lipid analysis technologies have enabled the description of more than 40 diseases linked to defects in enzymes involved in these pathways. Some of these defects present in infancy or childhood but most of them are diagnosed in adolescence or adulthood. In this review we focus on those with adult presentation.
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Murphy, Robert C., and Simon J. Gaskell. Tandem Mass Spectrometry of Lipids: Molecular Analysis of Complex Lipids. Royal Society of Chemistry, The, 2014.

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Blokdijk, G. J. Sulfur Hexafluoride Lipid-Type A Microspheres; Complete Self-Assessment Guide. CreateSpace Independent Publishing Platform, 2018.

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Jardine, Alan G., and Rajan K. Patel. Lipid disorders of patients with chronic kidney disease. Edited by David J. Goldsmith. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199592548.003.0102.

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The risk of developing cardiovascular (CV) disease is increased in patients with chronic kidney disease (CKD) and although dyslipidaemia is a major contributory factor to the development of premature CV disease, the relationship is complex. Changes in lipid fractions are related to glomerular filtration rate and the presence and severity of proteinuria, diabetes, and other confounding factors. The spectrum of CV disease changes from lipid-dependent, atheromatous coronary disease in early CKD to lipid-independent, non-coronary disease, manifesting as heart failure, and sudden cardiac death in advanced and end-stage renal disease. Statin-based lipid-lowering therapy is proven to reduce coronary events across the spectrum of CKD. The relative reduction in overall CV events, however, diminishes as CKD progresses and the proportion of lipid-dependent coronary events declines. There is nevertheless a strong argument for the use of statin-based therapy across the spectrum of CKD. The argument is particularly strong for those patients with progressive renal disease who will eventually require transplantation, in whom preventive therapy should start as early as possible. The SHARP study established the benefits and endorses the use of lipid-lowering therapy in CKD 3-4 but uncertainty about the value of initiation of statin therapy in CKD 5 remains. There is, however, no rationale for stopping agents started earlier in the course of the illness for compelling indications, particularly in those who will ultimately be transplanted. The place of high-density lipoprotein-cholesterol raising and triglyceride lowering therapy needs to be assessed in trials. Modifying dyslipidaemia in CKD has demonstrated that lipid-dependent atheromatous cardiovascular disease is only one component of the burden of CV disease in CKD patients, that this is proportionately less in advanced CKD, and that modification of lipid profiles is only one part of CV risk management.
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Blaser, Annika Reintam, and Adam M. Deane. Normal physiology of nutrition. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0201.

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Energy is derived from three major categories of macronutrient—carbohydrate, lipid, and protein. While energy requirements to maintain stable weight can be estimated, it is uncertain if meeting these energy requirements improves outcomes in the critically ill. In health, excess energy is stored via non-oxidative metabolism and during periods of inadequate energy delivery catabolism of storage products occurs. Both storing and using the stores cost energy, each may require up to quarter of energy contained in stored nutrient. Excess carbohydrate stored as glycogen is easily available, albeit in a limited amount. Storage of lipid is the largest energy repository, but requires complex metabolism and is limited by low oxidative capacity. Protein catabolism normally contributes less than 5% of energy requirements, but during periods of inadequate energy delivery or increased catabolism there is a marked increase in endogenous protein breakdown.
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Aston, Stephen, Geraint Davies, and Nick Beeching. Mycobacterial infection other than tuberculosis. Edited by Patrick Davey and David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0311.

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Mycobacteria are aerobic bacilli with a lipid-rich cell wall and are widespread both in the environment and in animals. Many species within the genus cause disease in humans, most notably those of the Mycobacterium tuberculosis complex, which cause tuberculosis, and Mycobacterium leprae, the causative agent of leprosy. Several other species, termed non-tuberculous mycobacteria, can cause chronic cutaneous, pulmonary, and disseminated infections. This chapter will briefly review infection with non-tuberculous mycobacteria and Mycobacterium leprae.
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Parlato, Marianna, and Jean-Marc Cavaillon. Innate immunity and the inflammatory cascade. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0299.

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Inflammation results from a complex interaction between a large number of mediators able to induce each other and to favour the generation of other inflammatory molecules (e.g. free radicals, lipid mediators, and proteases). The perpetuation of inflammation by these cascades of mediators is favoured by their ability to induce coagulation, leukocyte recruitment, and cell and tissue alteration (apoptosis, necrosis, and barrier disruption). Other cascades of mediators occur to generate anti-inflammatory mediators favouring the healing process. A neuroendocrine loop and neuromediators from central and peripheral nervous system are also involved in the process, allowing a return to homeostasis.
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Book chapters on the topic "Lipide complexe"

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Brady, Roscoe O., and Roscoe O. Brady. "Complex Lipid Catabolism." In Lysosomal Storage Disorders, 45–52. Boston, MA: Springer US, 2007. http://dx.doi.org/10.1007/978-0-387-70909-3_4.

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Huang, Qiang, Xu Chen, Shaokang Wang, and Jianzhong Zhu. "Amylose–Lipid Complex." In Starch Structure, Functionality and Application in Foods, 57–76. Singapore: Springer Singapore, 2020. http://dx.doi.org/10.1007/978-981-15-0622-2_5.

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Kuksis, A. "Mass spectrometry of complex lipids." In Lipid Analysis in Oils and Fats, 181–249. Boston, MA: Springer US, 1998. http://dx.doi.org/10.1007/978-1-4613-1131-7_6.

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Pengelly, Andrew. "Plant lipids and alkylamides." In The constituents of medicinal plants, 202–14. 3rd ed. Wallingford: CABI, 2021. http://dx.doi.org/10.1079/9781789243079.0011.

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Abstract Plant lipids are classified as primary metabolites, and therefore essential for life. Unlike secondary metabolites, lipids are universally present in plants, articularly in their seeds, varying only in their abundance and chemical composition. All lipids are composed of a hydrocarbon skeleton with one or more oxygen (O) substitutes. Plant lipids are derived from the acetate pathway via molonyl CoA, a pathway that leads to fatty acids, polyketides, polyacetylenes, phospholipids, prostaglandins and alkylamides. The more complex lipids may contain elements such as phosphorus, nitrogen or sulfur. Tabulated data are given on selective list of fixed oils, lists of some of the main dietary sources of essential fatty acids, botanical sources of γ-linolenic acid, and medicinal plants containing isobutylamides.
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Galjaard, Hans, André T. Hoogeveen, Frans W. Verheijen, Rob Willemsen, Sylvia Palmeri, Grazia Mancini, Lars Svennerholm, and Jan Erik Månsson. "The ß-Galactosidase — Sialidase Complex." In Enzymes of Lipid Metabolism II, 753–70. Boston, MA: Springer US, 1986. http://dx.doi.org/10.1007/978-1-4684-5212-9_90.

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Hirota, Sadao, and Nejat Düzgüneş. "Viscometric Analysis of DNA-Lipid Complexes." In Methods in Molecular Biology, 369–83. Totowa, NJ: Humana Press, 2009. http://dx.doi.org/10.1007/978-1-60761-447-0_25.

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Smith, Louis C., Stephen Gottschalk, Jochen Hauer, Savio L. C. Woo, and James T. Sparrow. "Nonviral Gene Delivery Using Dna: Synthetic Peptide Complexes." In Drugs Affecting Lipid Metabolism, 337–45. Dordrecht: Springer Netherlands, 1996. http://dx.doi.org/10.1007/978-94-009-0311-1_39.

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Dekker, Peter J. T. "Protein Complexes Involved in Import of Mitochondrial Preproteins." In Lipid and Protein Traffic, 9–16. Berlin, Heidelberg: Springer Berlin Heidelberg, 1998. http://dx.doi.org/10.1007/978-3-642-51463-0_2.

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Kern, Jan, Athina Zouni, Albert Guskov, and Norbert Krauß. "Lipids in the Structure of Photosystem I, Photosystem II and the Cytochrome b 6 f Complex." In Lipids in Photosynthesis, 203–42. Dordrecht: Springer Netherlands, 2009. http://dx.doi.org/10.1007/978-90-481-2863-1_10.

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Michaelis, Uwe, and Michael Teifel. "Cationic Lipid Complexes to Target Tumor Endothelium." In Vascular-Targeted Therapies in Oncology, 221–45. Chichester, UK: John Wiley & Sons, Ltd, 2006. http://dx.doi.org/10.1002/0470035439.ch13.

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Conference papers on the topic "Lipide complexe"

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Hatakeyama, Masaomi, Roland Faller, Michio Tokuyama, Irwin Oppenheim, and Hideya Nishiyama. "Coarse Grained Simulation of Lipid Membrane and Triblock Copolymers." In COMPLEX SYSTEMS: 5th International Workshop on Complex Systems. AIP, 2008. http://dx.doi.org/10.1063/1.2897852.

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Hibino, M. "Study of Fluidity of Lipid Membranes Using Single Molecule Microscopy." In SLOW DYNAMICS IN COMPLEX SYSTEMS: 3rd International Symposium on Slow Dynamics in Complex Systems. AIP, 2004. http://dx.doi.org/10.1063/1.1764158.

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Fujiwara, Hisashi. "New Aspect of the Spontaneous Formation of a Bilayer Lipid Membrane." In SLOW DYNAMICS IN COMPLEX SYSTEMS: 3rd International Symposium on Slow Dynamics in Complex Systems. AIP, 2004. http://dx.doi.org/10.1063/1.1764279.

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Ma, Q. H., Y. W. Wang, X. F. Lin, D. Luo, and N. Gu. "Preparation, Characterization and Photoprotection of Tocopherol Loaded Nanostructured Lipid Carriers." In 2007 IEEE/ICME International Conference on Complex Medical Engineering. IEEE, 2007. http://dx.doi.org/10.1109/iccme.2007.4381722.

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Takeda, T. "Neutron Spin Echo Study on Slow Dynamics of Lipid Bilayers in the DPPC/D2O/CaCl2 System." In SLOW DYNAMICS IN COMPLEX SYSTEMS: 3rd International Symposium on Slow Dynamics in Complex Systems. AIP, 2004. http://dx.doi.org/10.1063/1.1764082.

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Shinoda, W. "Molecular dynamics study of the Lipid Bilayers: Effects of the Chain Branching on the Structure and Dynamics." In SLOW DYNAMICS IN COMPLEX SYSTEMS: 3rd International Symposium on Slow Dynamics in Complex Systems. AIP, 2004. http://dx.doi.org/10.1063/1.1764171.

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Jiang, Zi-Hua, Mimi V. Bach, Dongxu Qiu, Sham S. Gandhi, Wladyslaw A. Budzynski, Mark J. Krantz, Mark R. Rao Koganty, and Mark B. Michael Longenecker. "NOVEL SYNTHETIC LIPID A ANALOGS CONTAINING UNNATURAL LIPID COMPLEXES: POTENTIAL LIGANDS FOR TOLL-LIKE RECEPTOR 4." In XXIst International Carbohydrate Symposium 2002. TheScientificWorld Ltd, 2002. http://dx.doi.org/10.1100/tsw.2002.466.

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Ma, Q. H., S. Tong, L. Duan, Q. Xia, and N. Gu. "Comparison of Stability for All-trans Retinoic Acid Nanosuspensions and Lipid Nanoparticle Formulations." In 2007 IEEE/ICME International Conference on Complex Medical Engineering. IEEE, 2007. http://dx.doi.org/10.1109/iccme.2007.4381721.

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Schick, K. P., S. Shapiro, G. Tuszynski, and J. Slawek. "SULFATIDES AND GLYCOLIPIDS IN PLATELETS AND ENDOTHELIAL CELLS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643641.

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Sulfatides are sulfated glycolipids which are negatively charged and thought to influence receptor mediated activities. Sulfatides have the capacity to provide a surface for the initiation of in vitro coagulation tests and these acidic lipids represent the potential biological surface for the initiation of the contact and intrinsic systems in vivo. Several sulfatides have been demonstrated in blood platelets. We have investigated sulfatides and other glycolipids in endothelial cells and platelets in order to define the cellular sources for sulfatides that would be available for influencing hemostasis. Endothelial cells were derived from primary cultures of human umbilical veins and human platelets were obtained from freshly-collected blood. Cellular lipids were extracted by the Folch method. Sulfatides and glycolipids were purified by silicic acid chromatography, separated by thin-layer chromatography, and quantitated by the assay of sphingosine. Glycolipids were also analyzed by HPLC. Globoside was found to be the predominant glycolipid in endothelial cells while lactosyl ceramide was the predominant glyco-lipid in platelets. Sulfatides were detected by two approaches: 1) Sulfatide synthesis by the incorporation of [35S]-Sulfate; 2) The specific binding of [125I]-thrombospondin and [125I]-von Willebrand’s factor (vWF) to sulfatides separated by thin-layer chromatography (TLC). Several sulfatides were identified in endothelial cells and platelets by virtue of the incorporation of [35S]-sulfate into glycolipids separated by TLC. [125I]-TSP and [125I]-vWF bound to the glycolipids that had incorporated [35S]-sulfate. [35S]-sulfate was primarily incorporated into sulfated galactosyl ceramide but both cells also synthesized complex glycolipids. TSP and vWF were shown to bind to sulfated galactosyl ceramide, a band that comigrated with glycosyl ceramide as well as with two more complex sulfatides in both cells. However, differences in sulfatide synthesis and binding of TSP to sulfatides were observed in endothelial cells from that in platelets. The study indicates that endothelial cells and platelets contain several sulfatides and thus are potential sources for sulfatides for the initiation of coagulation.
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Komura, Shigeyuki, and Ou-Yang Zhong-can. "High- and low-pitch helical structures of titled chiral lipid bilayers." In The 8th tohwa university international symposium on slow dynamics in complex systems. AIP, 1999. http://dx.doi.org/10.1063/1.58452.

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Reports on the topic "Lipide complexe"

1

Yang, Wei. Functional Proteomic Analysis of Lipid Raft Kinase Complexes. Fort Belvoir, VA: Defense Technical Information Center, August 2009. http://dx.doi.org/10.21236/ada511273.

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Dolan, Brian P. A Novel Therapeutic Vaccine for Metastatic Mammary Carcinoma: Focusing MHC/Peptide Complexes to Lipid Rafts. Fort Belvoir, VA: Defense Technical Information Center, May 2005. http://dx.doi.org/10.21236/ada437901.

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