Relevant bibliographies by topics / Lipidoid

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'Lipidoid'

Author: Grafiati
Published: 4 June 2021
Last updated: 15 February 2022

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the lists of relevant articles, books, theses, conference reports, and other scholarly sources on the topic 'Lipidoid.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Journal articles on the topic "Lipidoid"

1

Ma, Feihe, Liu Yang, Zhuorui Sun, Jinjin Chen, Xuehui Rui, Zachary Glass, and Qiaobing Xu. "Neurotransmitter-derived lipidoids (NT-lipidoids) for enhanced brain delivery through intravenous injection." Science Advances 6, no. 30 (July 2020): eabb4429. http://dx.doi.org/10.1126/sciadv.abb4429.

Full text
Abstract:
Safe and efficient delivery of blood-brain barrier (BBB)–impermeable cargos into the brain through intravenous injection remains a challenge. Here, we developed a previously unknown class of neurotransmitter–derived lipidoids (NT-lipidoids) as simple and effective carriers for enhanced brain delivery of several BBB-impermeable cargos. Doping the NT-lipidoids into BBB-impermeable lipid nanoparticles (LNPs) gave the LNPs the ability to cross the BBB. Using this brain delivery platform, we successfully delivered amphotericin B (AmB), antisense oligonucleotides (ASOs) against tau, and genome-editing fusion protein (−27)GFP-Cre recombinase into the mouse brain via systemic intravenous administration. We demonstrated that the NT-lipidoid formulation not only facilitates cargo crossing of the BBB, but also delivery of the cargo into neuronal cells for functional gene silencing or gene recombination. This class of brain delivery lipid formulations holds great potential in the treatment of central nervous system diseases or as a tool to study the brain function.
APA, Harvard, Vancouver, ISO, and other styles
2

Chen, Jinjin, Min Qiu, Zhongfeng Ye, Thomas Nyalile, Yamin Li, Zachary Glass, Xuewei Zhao, Liu Yang, Jianzhu Chen, and Qiaobing Xu. "In situ cancer vaccination using lipidoid nanoparticles." Science Advances 7, no. 19 (May 2021): eabf1244. http://dx.doi.org/10.1126/sciadv.abf1244.

Full text
Abstract:
In situ vaccination is a promising strategy for cancer immunotherapy owing to its convenience and the ability to induce numerous tumor antigens. However, the advancement of in situ vaccination techniques has been hindered by low cross-presentation of tumor antigens and the immunosuppressive tumor microenvironment. To balance the safety and efficacy of in situ vaccination, we designed a lipidoid nanoparticle (LNP) to achieve simultaneously enhancing cross-presentation and STING activation. From combinatorial library screening, we identified 93-O17S-F, which promotes both the cross-presentation of tumor antigens and the intracellular delivery of cGAMP (STING agonist). Intratumor injection of 93-O17S-F/cGAMP in combination with pretreatment with doxorubicin exhibited excellent antitumor efficacy, with 35% of mice exhibiting total recovery from a primary B16F10 tumor and 71% of mice with a complete recovery from a subsequent challenge, indicating the induction of an immune memory against the tumor. This study provides a promising strategy for in situ cancer vaccination.
APA, Harvard, Vancouver, ISO, and other styles
3

de Groot, Anne Marit, Kaushik Thanki, Monique Gangloff, Emily Falkenberg, Xianghui Zeng, Djai C. J. van Bijnen, Willem van Eden, et al. "Immunogenicity Testing of Lipidoids In Vitro and In Silico: Modulating Lipidoid-Mediated TLR4 Activation by Nanoparticle Design." Molecular Therapy - Nucleic Acids 11 (June 2018): 159–69. http://dx.doi.org/10.1016/j.omtn.2018.02.003.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

Knapp, Christopher M., Penghong Guo, and Kathryn A. Whitehead. "Lipidoid Tail Structure Strongly Influences siRNA Delivery Activity." Cellular and Molecular Bioengineering 9, no. 3 (April 12, 2016): 305–14. http://dx.doi.org/10.1007/s12195-016-0436-9.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

Ho, Tzu-Chieh, Hye Sung Kim, Yumei Chen, Yamin Li, Mark W. LaMere, Caroline Chen, Hui Wang, et al. "Scaffold-mediated CRISPR-Cas9 delivery system for acute myeloid leukemia therapy." Science Advances 7, no. 21 (May 2021): eabg3217. http://dx.doi.org/10.1126/sciadv.abg3217.

Full text
Abstract:
Leukemia stem cells (LSCs) sustain the disease and contribute to relapse in acute myeloid leukemia (AML). Therapies that ablate LSCs may increase the chance of eliminating this cancer in patients. To this end, we used a bioreducible lipidoid-encapsulated Cas9/single guide RNA (sgRNA) ribonucleoprotein [lipidoid nanoparticle (LNP)–Cas9 RNP] to target the critical gene interleukin-1 receptor accessory protein (IL1RAP) in human LSCs. To enhance LSC targeting, we loaded LNP-Cas9 RNP and the chemokine CXCL12α onto mesenchymal stem cell membrane–coated nanofibril (MSCM-NF) scaffolds mimicking the bone marrow microenvironment. In vitro, CXCL12α release induced migration of LSCs to the scaffolds, and LNP-Cas9 RNP induced efficient gene editing. IL1RAP knockout reduced LSC colony-forming capacity and leukemic burden. Scaffold-based delivery increased the retention time of LNP-Cas9 in the bone marrow cavity. Overall, sustained local delivery of Cas9/IL1RAP sgRNA via CXCL12α-loaded LNP/MSCM-NF scaffolds provides an effective strategy for attenuating LSC growth to improve AML therapy.
APA, Harvard, Vancouver, ISO, and other styles
6

Sui, Lei, Ming Wang, Qianqian Han, Liming Yu, Lan Zhang, Leilei Zheng, Junxiang Lian, et al. "A novel Lipidoid-MicroRNA formulation promotes calvarial bone regeneration." Biomaterials 177 (September 2018): 88–97. http://dx.doi.org/10.1016/j.biomaterials.2018.05.038.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

Уварова, В. И., Т. Р. Низамов, М. А. Абакумов, С. С. Водопьянов, Т. О. Абакумова, И. В. Салтыкова, П. С. Могильников, И. В. Щетинин, and А. Г. Мажуга. "Липидоподобные наночастицы оксида железа как платформа для доставки нуклеиновых кислот в печень." НАНОМЕДИЦИНА, no. 6 (December 30, 2018): 43–52. http://dx.doi.org/10.24075/vrgmu.2018.080.

Full text
Abstract:
Адресная доставка антисмысловых препаратов является перспективной технологией, на основе которой возможна разработка высокоэффективных лекарственных средств для терапии широкого спектра заболеваний. Однако недостаточная стабильность РНК в биологических средах и гидрофильность, ограничивающая проникновение через клеточные мембраны, существенно сужают их использование в клинической практике. Целью исследования была разработка средств доставки антисмысловых препаратов в гепатоциты печени с помощью липидоподобных магнитных наночастиц (ЛНЧ). Кубические магнитные наночастицы (НЧ) со средними размерами 16 и 27 нм синтезировали методом высокотемпературного разложения прекурсора — олеата железа (III) и химически модифицировали формуляцией, включающей катионный липидоид С12-200. Магнитные НЧ обладают хорошими МРТ-контрастными свойствами, биораспределение ЛНЧ исследовали in vivo на линейных мышах BALB/c с помощью МР-томографа. С этой же целью провели последующее гистологическое исследование срезов печени. Наночастицы меньшего размера не продемонстрировали цитотоксического действия по отношению к клеточным линиям HepG2 и Huh7, а для НЧ кубической формы большего размера IC составила 21,5 мкг/мл для HepG2 и 126 мкг/мл для Huh7. Выявлено, что НЧ меньшего размера аккумулируются преимущественно в гепатоцитах печени, а НЧ большего размера — в селезенке, в печени же они накапливаются главным образом в макрофагах. Такая разница может быть вызвана большим гидродинамическим размером НЧ, которые имеют больший размер магнитного ядра. Образец с ядром меньшего размера является наиболее эффективной платформой для доставки антисмысловых препаратов в гепатоциты.
APA, Harvard, Vancouver, ISO, and other styles
8

Li, Yamin, Anirban Chakraborty, Jinjin Chen, and Qiaobing Xu. "Combinatorial Library of Light-Cleavable Lipidoid Nanoparticles for Intracellular Drug Delivery." ACS Biomaterials Science & Engineering 5, no. 5 (April 17, 2019): 2391–98. http://dx.doi.org/10.1021/acsbiomaterials.9b00445.

Full text
APA, Harvard, Vancouver, ISO, and other styles
9

Li, Yamin, Rachel Jarvis, Kuixin Zhu, Zachary Glass, Roza Ogurlu, Peiyang Gao, Peixuan Li, et al. "Protein and mRNA Delivery Enabled by Cholesteryl‐Based Biodegradable Lipidoid Nanoparticles." Angewandte Chemie International Edition 59, no. 35 (June 15, 2020): 14957–64. http://dx.doi.org/10.1002/anie.202004994.

Full text
APA, Harvard, Vancouver, ISO, and other styles
10

Akinc, Akin, Michael Goldberg, June Qin, J. Robert Dorkin, Christina Gamba-Vitalo, Martin Maier, K. Narayanannair Jayaprakash, et al. "Development of Lipidoid–siRNA Formulations for Systemic Delivery to the Liver." Molecular Therapy 17, no. 5 (May 2009): 872–79. http://dx.doi.org/10.1038/mt.2009.36.

Full text
APA, Harvard, Vancouver, ISO, and other styles
More sources

Dissertations / Theses on the topic "Lipidoid"

1

Kasiewicz, Lisa N. "siRNA Loaded Lipidoid Nanoparticles and the Immune System." Research Showcase @ CMU, 2018. http://repository.cmu.edu/dissertations/1146.

Full text
Abstract:
Delivery vehicles are necessary for many therapeutics to overcome the various challenges in their path. It is clear, however, that the relationship between delivery vehicles and the immune system is a complex one. One such delivery vehicle is the lipidoid nanoparticle, which has been shown to be potent in several cell types. This thesis details the first time lipidoids have been used for wound delivery, and demonstrates the successful silencing of an inflammatory protein, TNFα, in the context of diabetic ulcers. Knockdown is seen in an in vitro macrophage-fibroblast coculture model, as well as in nondiabetic and diabetic mice wound models. Lipidoids silence roughly half of the TNFα gene expression in the diabetic wound and have been shown to help the wound close faster than untreated controls. Of course, immune activation can decrease therapeutic efficacy or trigger dangerous reactions in the patient. Learning more about what chemical moieties cause an immune response would allow for the design of a particle that could better resist immune clearance and avoid the creation of a secondary response. This thesis investigated the effect of a lipidoid library on the immune system using a two pronged approach. The lipidoids were first tested against human peripheral blood mononuclear cells and then were injected into mice to probe the in situ immune response. Several types of B cells were examined in this latter case, namely germinal center B cells, plasma cells, and memory B cells. A T cell dependent response occurred, favoring memory B cells for most of the lipidoids tested. There was an increase in free antibody in the blood that reflected this increase in antibody producing cells. Nitrogen rings and carbon tail lengths of eleven and twelve carbons were particularly reactive, though it appears that the amine head group determines immune response more than the tail. Further work will analyze whether these increases in immune cells reflect a loss of therapeutic efficacy, as current ramifications are unclear. An in-depth T cell subset analysis with flow cytometry would also help complete the picture.
APA, Harvard, Vancouver, ISO, and other styles
2

Ball, Rebecca L. "Oral Delivery of Lipid Nanoparticles with siRNA for the Treatment of Intestinal Diseases." Research Showcase @ CMU, 2018. http://repository.cmu.edu/dissertations/1136.

Full text
Abstract:
Intestinal diseases affect millions of people worldwide. Recently, a number of proteins have been shown to be upregulated in the intestinal cells of patients that contribute to disease progression. Therefore, these diseases could be amenable to RNA interference technology (RNAi). Utilizing RNAi to deliver short interfering ribonucleic acid (siRNA) to intestinal cells shows promise for the treatment of diseases by specifically suppressing the expression of disease relevant proteins. A class of lipid nanoparticles termed lipidoid nanoparticles (LNPs) have been shown previously to potently deliver siRNA to several cell types in vitro and in vivo. Here, we seek to establish the utility of lipidoid nanoparticles (LNPs) in the context of oral siRNA delivery to intestinal cells for the treatment of intestinal diseases. Initial in vitro studies demonstrated that the siRNA-loaded LNPs mediated potent, dose dependent, and durable gene silencing in Caco-2 intestinal cells without inducing significant cytotoxicity or altering intestinal barrier function. LNP stability studies revealed that LNPs in an aqueous buffer remained stable for long periods of time when stored in the refrigerator (2 °C) compared to the freezer (-20 °C) or at room temperature. In addition, LNPs remained stable upon lyophilization with the addition of trehalose or sucrose to the LNP solution before freeze-drying. To determine potential for oral LNP delivery, we studied LNP stability under gastrointestinal (GI) tract conditions. LNPs remained potent and stable following exposure to solutions of varied pH, including pH values as low as 1.2. However, efficacy decreased following exposure to increasing concentrations of pepsin and bile salts. Mouse oral biodistribution studies indicated that siRNA-loaded lipid nanoparticles were retained in the GI tract for at least 8 hours. Confocal microscopy confirmed that nanoparticles entered the epithelial cells of the mouse small intestine and colon. Oral LNP therapeutic efficacy was measured in an inflammatory bowel disease (IBD) mouse model by targeting the upregulated genes myosin light chain kinase (MLCK) and Interleukin 18 receptor (IL18R) and were found to prevent some IBD disease progression. Lastly, a formulation for the co-delivery of siRNA and messenger RNA (mRNA) was developed and it was discovered that a negatively charged polymer can be used to improve LNP efficacy. Together, these studies have advanced our knowledge of lipid nanoparticle stability, and potential as an orally delivered intestinal therapeutic.
APA, Harvard, Vancouver, ISO, and other styles
3

Knapp, Christopher M. "Engineering siRNA Lipid Nanoparticles for the Treatment of Mantle Cell Lymphoma." Research Showcase @ CMU, 2017. http://repository.cmu.edu/dissertations/886.

Full text
Abstract:
Mantle cell lymphoma (MCL) is an extremely difficult to treat subtype of non-Hodgkin lymphoma (NHL) with a low patient survival rate compared to most common cancers. Recently, nanoparticle delivery systems have received a great deal of interest for treating NHL. One of the more promising cargo options for these systems is short interfering RNA (siRNA). siRNA is a 18-23 nucleotide long double stranded RNA that is used to inhibit the protein expression of target mRNAs in a sequence specific manner. MCLs have several commonly overexpressed genes compared to normal cells making it an ideal candidate for siRNA therapies. For RNA interference to occur, A delivery vehicle is needed for the siRNA to reach the cytoplasm of the cell. In this thesis, ionizable lipid-like materials termed lipidoids are formulated into lipid nanoparticles (LNPs) to deliver siRNA. A new library of lipidoids is constructed to gain a better understanding of how the lipidoid tail-structure affects the silencing ability of LNPs. A novel tail precursor is identified as conferring potency to LNPs. Then, LNPs are used to silence genes within difficult to transfect MCL cells. LNPs targeting the anti-apoptotic protein Mcl-1 exhibit potent gene silencing and cause an increase in the fraction of cells undergoing apoptosis. This is important because there is no therapeutic that is FDA approved that targets this commonly overexpressed protein. Because of this LNP’s potency, siRNAs targeting multiple genes can be encapsulated into LNPs without causing unwanted toxicity. LNPs targeting several genes in multiple pathways cause a larger fraction of MCL cells to undergo apoptosis compared to cells treated with LNPs targeting only one gene. A major issue in cancer therapeutics is that the majority of nanoparticles accumulate in the liver. In an effort to improve the delivery of LNPs to target cells, changes to their formulations and administration methods are investigated as a means to improve LNP circulation time, biodistribution, and silencing ability. Overall, this work identifies lipidoid nanoparticles as potent siRNA delivery systems to treat MCL and investigates key properties for further improvement in LNP siRNA delivery to target cells.
APA, Harvard, Vancouver, ISO, and other styles
4

Silva, Fábia Capeleiro Henriques Siqueira da. "Lipidose hepática felina." Master's thesis, Universidade Técnica de Lisboa. Faculdade de Medicina Veterinária, 2012. http://hdl.handle.net/10400.5/4578.

Full text
Abstract:
Dissertação de Mestrado Integrado em Medicina Veterinária
Inicialmente descrita como uma doença idiopática por Barsanti et al em 1977, a lipidose hepática felina (LHF) é caracterizada actualmente como uma patologia secundária a um processo primário em mais de 95% dos casos. Esta patologia é mais comum em gatos com condição corporal elevada sujeitos a um período prolongado de privação de alimento. Os gatos apresentam alguma predisposição para a acumulação de triglicéridos a nível hepático o que, em caso de doença, resulta em vacuolização gorda hepatocelular. Durante o período de anorexia ao qual estão sujeitos, vai ocorrer lipólise da gordura das reservas corporais. Apesar de os mecanismos fisiopatológicos que desencadeiam esta síndrome não serem completamente conhecidos, verifica-se um desequilíbrio na circulação de ácidos gordos entre o fígado e o tecido adiposo, resultando no comprometimento na capacidade de remoção dos ácidos gordos da corrente sanguínea por parte do fígado. O objectivo do estudo de casos consistiu na caracterização de uma amostra de sete gatos diagnosticados com lipidose hepática felina, atendendo à predisposição de género, idade e peso. Descreveram-se os sinais clínicos, físicos e laboratoriais de todos os pacientes. Os gatos analisados foram apresentados à consulta com história de anorexia (71%), perda de peso (57%), prostração (57%), obstipação (57%) e vómito, adipsia e anúria com menor incidência. O período de anorexia variou entre sete e quinze dias, tendo duração média de onze dias.
ABSTRACT - Initially described as an idiopathic disease by Barsanti et al in 1977, feline hepatic lipidosis (FHL) is characterized as a current condition secondary to a primary process in over 95% of cases. This condition is more common in cats with high body condition subject to a prolonged period of food deprivation. The cats have a predisposition to the accumulation of triglycerides in the liver which, in case of disease, results in fat hepatocellular vacuolation. During the period of anorexia which they are subjected, lipolysis of fat from body stores will occur. Even though the physiopathological mechanisms that trigger this syndrome are not fully understood, there is an imbalance in the movement of fatty acids between the liver and adipose tissue, resulting in impairment of the ability to remove the fatty acids from the bloodstream by the liver. The aim of this study consisted in the characterization of a sample of seven cats diagnosed with feline hepatic lipidosis, given the predisposition of gender, age and weight. The clinical signs, physical and laboratory examinations were described for all patients. The cats were presented to consultation with a history of anorexia (71%), weight loss (57%), prostration (57%), constipation (57%) and vomiting, adipsia, and anuria with lower incidence. The period of anorexia was between seven to fifteen days, and the average was eleven days. Changes in the physical examination with the highest incidence were jaundice (71%), dehydration (71%), abdominal pain on palpation (43%) and dysphagia (14%). The complementary exams showed increased activity of liver enzymes and increased liver parenchyma hyperecogenecity was shown in the abdominal ultrasonography. The primary disease was diagnosed in five cases. The treatment was directed to the primary cause, in cases where it has been determined, and in other cases it directed the treatment for the disease likely. Of the seven cats in the study, treatment was successful in five cases and two cats were euthanized.
APA, Harvard, Vancouver, ISO, and other styles
5

Sadowski, Tomasz [Verfasser], Kai [Gutachter] Simons, and Michael [Gutachter] Meurer. "Das physiologische Lipidom menschlicher Epidermis : The physiological lipidome of human epidermis / Tomasz Sadowski ; Gutachter: Kai Simons, Michael Meurer." Dresden : Technische Universität Dresden, 2019. http://d-nb.info/1227196695/34.

Full text
APA, Harvard, Vancouver, ISO, and other styles
6

Sadowski, Tomasz [Verfasser], Kai Gutachter] Simons, and Michael [Gutachter] [Meurer. "Das physiologische Lipidom menschlicher Epidermis : The physiological lipidome of human epidermis / Tomasz Sadowski ; Gutachter: Kai Simons, Michael Meurer." Dresden : Technische Universität Dresden, 2019. http://d-nb.info/1227196695/34.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

Reis, Tânia Cristina Resendes dos. "Contribuição para o estudo do desenvolvimento de colangite em gatos com lipidose hepática." Master's thesis, Universidade de Lisboa, Faculdade de Medicina Veterinária, 2019. http://hdl.handle.net/10400.5/17336.

Full text
Abstract:
Dissertação de Mestrado Integrado em Medicina Veterinária
Nesta dissertação pretendeu-se relacionar a lipidose hepática felina e a colangite neutrofílica, considerando a hipótese de que a primeira pudesse predispor ou conduzir ao desenvolvimento da segunda. Com base em 9 casos clínicos realizou-se também a caracterização e a comparação dos achados clínicos, dos parâmetros analíticos, da ecografia abdominal, da citologia hepática e da microbiológia de bílis, entre animais com suspeita de uma destas afeções ou ambas. Os critérios de inclusão abrangeram felinos, independentemente do sexo ou idade, que apresentassem alterações ecográficas e/ou ao exame citológico compatíveis com lipidose hepática felina e/ou colangite, e aos quais tivesse sido realizada cultura microbiológica de bílis. A citologia hepática foi realizada em 67% destes animais e permitiu a sua separação em grupos e subgrupos. No grupo A incluiram-se os animais com evidências de lipidose hepática felina confirmada citologicamente - casos 1,2,4,7,8, (56%) e no grupo B os animais com suspeita desta doença, mas sem evidências da mesma ao exame citológico - caso 5 (11%). No grupo C incluiram-se os animais com suspeita clínica, analítica e imagiológica destas doenças, mas sem registo de citologia hepática - casos 3, 6 e 9 (33%). O grupo A foi ainda subdividido em A1 e A2, tendo por base a suspeita de colangite concomitante ou não, respetivamente. Todos os animais motraram alterações da ecotextura hepática - 89% exibiram hiperecogenecidade hepática e apenas 11% (grupo B) hipoecogenecidade. Deste modo conclui-se que a presença concomitante de lipidose hepática felina pode ser a razão do aumento da ecogenecidade hepática muitas vezes descrito nos animais com colangite. Dos animais submetidos a exame citológico, 83% identificou-se a presença de alterações compatíveis com a presença de lipidose hepática felina. Nos animais suspeitos de terem colangite, apenas foi possível observar presença de conteúdo inflamatório como no caso 5 (grupo B). Este resultado mostra que, na presença das duas doenças em concomitância, a citologia hepática preveligia o diagnostico de lipidose hepática felina, o que conduz a um diagnostico plausível, mas inapropriado desta afeção. Nestas situações recomenda- se a realização de histopatologia. Na cultura microbiológica de bílis mostrou-se negativa em 88% da amostra. Relativamente ao grupo com suspeita de colangite, a taxa de positividade foi de 14% (1 caso positivo). A cultura foi positiva ao crescimento de Staphylococcus epidermidis. A taxa de culturas positivas foi baixa e o microorganismo em questão pode ter sido isolado devido a contaminação cutânea da amostra ou pelos hábitos felinos de grooming. As maiores limitações do presente estudo passam pela baixa amostragem e pelo fato de não terem sido realizadas histopatologias hepáticas. Por esta última razão não foi possível fazer o diagnóstico definitivo de uma das afeções em estudo (colangite) e não foram observadas alterações do parênquima hepático que permitissem estabelecer a relação pretendida entre as duas doenças.
ABSTRACT - In this dissertation, it was intended to relate feline hepatic lipidosis and neutrophilic cholangitis, considering the hypothesis that the first could predispose or lead to the development of the second. In addition, the characterization and comparison of clinical findings, analytical parameters, abdominal ultrasonography, hepatic cytology and bile microbiology was made within group of 9 animals suspected of having one or both of these affections. The Inclusion criteria were felines, regardless of sex or age, with echographic and/or cytological abnormalities compatible with feline hepatic lipidosis and/or cholangitis, and that had a microbiological culture of bile. Hepatic cytology was performed in 67% of the total sample and allowed separation of the animals into groups and subgroups. In group A, were included the animals with suspicion of feline hepatic lipidosis confirmed by hepatic cytological examination - cases 1,2,4,7,8, (56%), and in group B were the animals with suspicion of feline hepatic lipidosis but with no evidence of this affection on cytological examination - case 5 (11%). Group C included the animals with clinical, analytic, and ultrasonografic suspicion of this affection but without record of hepatic cytological examination - cases 3, 6 and 9 (33%). Group A was further subdivided into A1 and A2, based on the suspicion of cholangitis concomitant or not, respectively. All animals presented hepatic echotexture abnormalities - 89% had hepatic hyperechogenicity and only 11% (group B) hypoechogenicity. Thus, it is concluded that the concomitant presence of feline hepatic lipidosis may be the reason for the increase in liver echogenicity often described in animals with cholangitis. Of the animals submitted to cytological examination, 83% showed the presence of alterations compatible with the presence of feline hepatic lipidosis. In the cases that were suspected of cholangitis, it was only possible to observe the presence of inflammatory contents in case 5 (group B). This result shows that, in the presence of both diseases, liver cytology confirms only the diagnosis of feline hepatic lipidosis, without confirmation of cholangitis. In these situations it is recommended to perform histopathology. Bile microbiological culture was negative in 88% of the animals. Regarding the cases with suspected cholangitis, the positivity rate was 14% (1 positive case). The culture was positive for Staphylococcus epidermidis. The rate of positive cultures was low and the microorganism in question may have been isolated due to skin contamination of the sample or due to the feline grooming habits. The major limitations of the present study were the low casuistic and the fact that hepatic histopathology was not performed. For this last reason, it was not possible to diagnose one of the affections under study (cholangitis). It was also not possible to observe alterations of the liver parenchyma and there to establish the desired relationship between the two diseases.
N/A
APA, Harvard, Vancouver, ISO, and other styles
8

Pranskūnienė, Laura. "Audinių kepenų morfologiniai pokyčiai." Master's thesis, Lithuanian Academic Libraries Network (LABT), 2014. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2014~D_20140305_140340-27984.

Full text
Abstract:
Audinių augintojai susiduria su įvairiomis problemomis taip pat ir kepenų ligomis, nes jos labai paplito tarp kailinių žvėrelių. Sergamumas turi neigiamą įtaka našumui, kailių kokybei, gyvybingumui. Todėl ieškoma susirgimo priežaščių ir būdų, kaip normalizuoti kailinių žvėrelių medžiagų apykaitą ir sumažinti sergamumą. Darbo tikslas: ištirti X ūkyje auginamų audinių kepenų pokyčių dažnumą ir patologinius morfologinius pokyčius. Darbo uždaviniai: • Nustatyti kepenų patologijų dažnumą audinėms ir įvertinti veiksnius, lemiančius kepenų pokyčius • Įvertinti tiriamų audinių makroskopinius ir mikroskopinius kepenų pakitimus, • Ištirti hepatozių, hepatitų pasireiškimą, atliekant patologinį anatominį ir histologinį tyrimus • Susieti plazmocitų infiltraciją kepenyse su kitais nustatomais pokyčiais organuose. Darbo atlikimo metodika: Patologiniam tyrimui buvo naudojami audinių lavonėliai, kurie buvo pristatyti į patologijos skyrių po eutanazijos ir kailiuko nudyrimo. Atlikti histologiniai ir morfologiniai kepenų tyrimai. Skrodžiant audines makroskopiškai įvertinta kepenų ir kitų organų (inkstų ir blužnies) patologiniai pokyčiai. Histologiniai preparatai dažyti hematoksilinu – eozinu. Rezultatai. Kepenų pakitimai nustatyti 93 proc. tirtų audinių. Dažniausiai pasitaikęs kepenų pokytis buvo – lipidozė 78 proc.. Taip pat buvo nustatyta negausi plazminių ląstelių infiltracija 17 proc., hepatitas 48 proc., nekrozė 30 proc., ląstelių pabrinkimas 17 proc., hepatocitų degeneracija 7proc... [toliau žr. visą tekstą]
Work object : to investigate in the most common liver patomorphological and patohistological findings in X farm minks liver tissue. Work tasks: • To determine the frequency of liver pathology and evaluation of the factors leading to the minks liver changes. • To investigate microscopical and morphological changes the liver tissue. • To investigate the occurrence of liver hepatosis and hepatitis during the anatomical and pathological research. Material and methods of the research. 50 mink autopsies have been performed. Detailed investigation of liver pathologic changes were done. Hematoxylin eosin had been used as a staining method of histological sections. Changes of plasmacytosis in liver had been analysed microscopically and morphologically. Results and findings. It was found that liver pathologies in mink are frequent. Established over 93 % cases from investigated minks. Mostly diagnosed liver changes in mink lipidosis 78 %. Also have been diagnosed plasma cells infiltration also called plasmacytosis 17 %, hepatitis 48 %, necrosis 30 %, cell swelling 17 %, hepatocytes degeneration 7 %, amyloidosis 4 %. Together with a plasmocytosis some other pathologies was present: liver lipidosis and inflammation 75 %, cell swelling 25%, hemosiderosis and necrosis 50 %.
APA, Harvard, Vancouver, ISO, and other styles
9

Pereira, Stéphanie Dorothée Melen Palha Ramos. "Clínica de animais exóticos e silvestres: patologias nutricionais em psitacídeos." Master's thesis, Universidade de Évora, 2014. http://hdl.handle.net/10174/14005.

Full text
Abstract:
O presente trabalho visa relatar a casuística observada durante o estágio curricular em clínica de animais exóticos e silvestres, no Centro Veterinário de Exóticos do Porto e no Parc Zoologique d’Amnéville. Esta será exposta em frequências absolutas e relativas que estarão representadas em gráficos e tabelas para que a interpretação das atividades desenvolvidas seja clara. De seguida, estará contemplada uma revisão bibliográfica subordinada a uma das emergências mais frequentemente assistidas - as patologias relacionadas com o mau maneio nutricional em psitacídeos de cativeiro. Após uma breve caracterização dos elementos da ordem Psittaciforme, segue-se a descrição da sua morfologia e fisiologia gastrointestinal, e uma revisão da sua alimentação na natureza. As patologias nutricionais mais comuns serão referenciadas, assim como a alimentação atualmente recomendada, a qual será nutricionalmente comparada as misturas de sementes. Por fim, será apresentado um caso clínico de um animal acompanhado durante o estágio, acometido pela lipidose hepática; Abstract: “Internship report on clinic of exotic and feral animals - nutritional pathologies in psittacines” The following work describes the activities performed during the internship on clinic of exotic and feral animals at Centro Veterinário de Exóticos do Porto and Parc Zoologique d'Amnéville. These will be displayed in absolute and relative frequencies, which, in turn, will be represented in graphics and tables to allow a clear interpretation of the developed activities. Then, a literature review will be made of the most frequently assisted emergencies - the pathologies related to a poor nutritional management in captive psittacines. A brief characterization of some elements of the Psittaciforme order will be followed by a description of their gastrointestinal morphology and physiology, and by a review of their food habits in the wild. The most common nutritional disorders will be referred, as well as the currently recommended diet, which will be nutritionally compared with seed mixtures. Finally, it will be presented a clinical case of an animal accompanied during the internship, suffering from hepatic lipidosis.
APA, Harvard, Vancouver, ISO, and other styles
10

Nicolaou, Anna. "On lipidomic methodologies [Editorial]." Master's thesis, Wiley, 2009. http://hdl.handle.net/10454/4573.

Full text
APA, Harvard, Vancouver, ISO, and other styles
More sources

Books on the topic "Lipidoid"

1

Mikhaĭlovich, Kuzin Aleksandr, ed. Radiat͡sionnai͡a biokhimii͡a membrannykh lipidov. Moskva: "Nauka", 1989.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
2

V, Poi͡urovskiĭ M., Neznamov G. G, and Evseenko L. S, eds. Nevrozy i perekisnoe okislenie lipidov. Moskva: Nauka, 1991.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
3

Venkov, Li͡ubomir. Lipidi v nervnata tŭkan. Sofii͡a: Bŭlgarska akademii͡a na naukite, 1985.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
4

Perekisnoe okislenie lipidov i kholodovoĭ faktor. Novosibirsk: "Nauka," Sibirskoe otd-nie, 1988.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
5

Hadley, Neil F. The adaptive role of lipidsin biological systems. New York: Wiley, 1985.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
6

Kozubek, Arkadiusz. Oddziaływanie wybranych nieizoprenoidowych lipidów fenolowych z błonami biologicznymi. Wrocław: Wydawn. Uniwersytetu Wrocławskiego, 1986.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
7

Koman, Václav. Štruktúry lipidov: Príspevok ku komplexnému štúdiu izomérov mastných kyselín a triacylglycerolov. Bratislava: Veda, 1986.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
8

A guide to phospholipid chemistry. New York: Oxford University Press, 1997.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
9

Szydłowski, Eugeniusz. Wpływ wysiłku fizycznego na proces peroksydacji lipidów i aktywność enzymów antyoksydacyjnych u osób zdrowych. Poznań: Akademia Wychowania Fizycznego, 1994.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
10

Christie, William W. Lipid analysis: Isolation, separation, identification and lipidomic analysis / William W. Christie and Xianlin Han. 4th ed. Bridgwater, England: Oily Press, 2010.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
More sources

Book chapters on the topic "Lipidoid"

1

Turnbull, Irene C., Ahmed A. Eltoukhy, Daniel G. Anderson, and Kevin D. Costa. "Lipidoid mRNA Nanoparticles for Myocardial Delivery in Rodents." In Methods in Molecular Biology, 153–66. New York, NY: Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-6588-5_10.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

Thanki, Kaushik, Xianghui Zeng, and Camilla Foged. "Preparation, Characterization, and In Vitro Evaluation of Lipidoid–Polymer Hybrid Nanoparticles for siRNA Delivery to the Cytosol." In Nanotechnology for Nucleic Acid Delivery, 141–52. New York, NY: Springer New York, 2019. http://dx.doi.org/10.1007/978-1-4939-9092-4_9.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

Lokras, Abhijeet, Camilla Foged, and Aneesh Thakur. "Engineering of Solid Dosage Forms of siRNA-Loaded Lipidoid–Polymer Hybrid Nanoparticles Using a Quality-by-Design Approach." In Methods in Molecular Biology, 137–57. New York, NY: Springer US, 2021. http://dx.doi.org/10.1007/978-1-0716-1298-9_9.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

Leung, Alexander K. C., Cham Pion Kao, Andrew L. Wong, Alexander K. C. Leung, Thomas Kolter, Ute Schepers, Konrad Sandhoff, et al. "Sulfatide Lipidosis." In Encyclopedia of Molecular Mechanisms of Disease, 2006–7. Berlin, Heidelberg: Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-540-29676-8_6231.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

Sakisaka, Shotaro, Masaru Harada, Motonari Kawaguchi, Eitaroh Taniguchi, and Kyuichi Tanikawa. "Congenital Lipidosis." In Liver Diseases and Hepatic Sinusoidal Cells, 337–46. Tokyo: Springer Japan, 1999. http://dx.doi.org/10.1007/978-4-431-67935-6_29.

Full text
APA, Harvard, Vancouver, ISO, and other styles
6

Schoeman, Tanya. "Hepatic Lipidosis." In Chronic Disease Management for Small Animals, 243–47. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2017. http://dx.doi.org/10.1002/9781119201076.ch25.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

Emi, Yohko, Ryuichi Higashiguchi, and Yoichi Konishi. "Pulmonary Lipidosis, Rat." In Respiratory System, 169–71. Berlin, Heidelberg: Springer Berlin Heidelberg, 1985. http://dx.doi.org/10.1007/978-3-642-96846-4_26.

Full text
APA, Harvard, Vancouver, ISO, and other styles
8

Metze, Dieter, Vanessa F. Cury, Ricardo S. Gomez, Luiz Marco, Dror Robinson, Eitan Melamed, Alexander K. C. Leung, et al. "Hereditary Dystopic Lipidosis." In Encyclopedia of Molecular Mechanisms of Disease, 830. Berlin, Heidelberg: Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-540-29676-8_8478.

Full text
APA, Harvard, Vancouver, ISO, and other styles
9

Casbas, Ferran, and Charlie Hodgman. "Mammalian Lipidomic Network." In The Art of Theoretical Biology, 34–35. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-33471-0_17.

Full text
APA, Harvard, Vancouver, ISO, and other styles
10

Konishi, Yoichi, and Ryuichi Higashiguchi. "Pulmonary Lipidosis, Rat." In Respiratory System, 270–72. Berlin, Heidelberg: Springer Berlin Heidelberg, 1996. http://dx.doi.org/10.1007/978-3-642-61042-4_28.

Full text
APA, Harvard, Vancouver, ISO, and other styles

Conference papers on the topic "Lipidoid"

1

Ghosh, A., J. E. Keating, R. D. Coakley, B. M. Ehrmann, N. E. Alexis, and R. Tarran. "Vaping Associated Alterations in the Lung Lipidome." In American Thoracic Society 2020 International Conference, May 15-20, 2020 - Philadelphia, PA. American Thoracic Society, 2020. http://dx.doi.org/10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a7682.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

"Cultivated sunflower high-throughput genotyping and lipidomic profiling." In Plant Genetics, Genomics, Bioinformatics, and Biotechnology. Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, 2019. http://dx.doi.org/10.18699/plantgen2019-037.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

"Issledovanie lipidov verkhovogo torfa kak perspektivnykh istochnikov antioksidantov." In Perspektivnye materialy s ierarkhicheskoy strukturoy dlya novykh tekhnologiy i nadezhnykh konstruktsiy, Khimiya nefti i gaza. Tomsk State University, 2018. http://dx.doi.org/10.17223/9785946217408/561.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

Lee, E., P. Morand, K. Williams, S. Wang, T. S. Wang, T. de Aguiar Vallim, and E. Tarling. "Defining the Lipidome of Alveolar Macrophages in Pulmonary Alveolar Proteinosis." In American Thoracic Society 2020 International Conference, May 15-20, 2020 - Philadelphia, PA. American Thoracic Society, 2020. http://dx.doi.org/10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a1192.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

RAMIREZ, N. N. V., C. RANZAN, M. FARENZENA, and J. O. TRIERWIELER. "NOVO MÉTODO PARA A QUANTIFICAÇÃO RÁPIDA DE LIPIDIOS EM MICROALGAS." In XX Congresso Brasileiro de Engenharia Química. São Paulo: Editora Edgard Blücher, 2015. http://dx.doi.org/10.5151/chemeng-cobeq2014-1153-20759-159503.

Full text
APA, Harvard, Vancouver, ISO, and other styles
6

Jackson, P., M. A. T. Freeberg, A. Perelas, J. R. Owen, S. Kates, K. R. Maddipati, K. Honn, P. J. Sime, and T. H. Thatcher. "Fatty Acyl Lipidomic Changes Converge Towards Increased Inflammation with Severity of COVID-19." In American Thoracic Society 2021 International Conference, May 14-19, 2021 - San Diego, CA. American Thoracic Society, 2021. http://dx.doi.org/10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a1285.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

Facina, G., NMCT Calux, MFR Silva, TCS Bonetti, ACP Nazario, and IDCG Silva. "P5-13-06: Lipidomic Profile Predicts Pathologic Complete Response to Neoadjuvant Weekly Paclitaxel Treatment." In Abstracts: Thirty-Fourth Annual CTRC‐AACR San Antonio Breast Cancer Symposium‐‐ Dec 6‐10, 2011; San Antonio, TX. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/0008-5472.sabcs11-p5-13-06.

Full text
APA, Harvard, Vancouver, ISO, and other styles
8

Henderson, Fiona, Hannah Johnston, Emrys Jones, Duncan Foster, Raghavendar T. Nagaraju, Michael Green, Michael Fairclough, et al. "Abstract 4109: Multi-modality imaging to interrogate lipidome changes during melanoma progression in zebrafish." In Proceedings: AACR Annual Meeting 2018; April 14-18, 2018; Chicago, IL. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1538-7445.am2018-4109.

Full text
APA, Harvard, Vancouver, ISO, and other styles
9

Ramich, O., K. Kessler, M. Gerl, S. Hornemann, K. Petzke, M. Kemper, N. Rudovich, et al. "Plasma lipidome is dependent on meal timing and associated with parameters of glucose metabolism." In Diabetes Kongress 2019 – 54. Jahrestagung der DDG. Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-1688151.

Full text
APA, Harvard, Vancouver, ISO, and other styles
10

Meyer-Bäse, Anke, Robert Görke, Huan He, Mark R. Emmett, Alan G. Marshall, and Charles A. Conrad. "Computational techniques to the topology and dynamics of lipidomic networks found in glioblastoma cells." In SPIE Defense, Security, and Sensing, edited by Teresa H. O'Donnell, Misty Blowers, and Kevin L. Priddy. SPIE, 2010. http://dx.doi.org/10.1117/12.849903.

Full text
APA, Harvard, Vancouver, ISO, and other styles
You might also be interested in the extended bibliographies on the topic 'Lipidoid' for particular source types:
Journal articles Dissertations / Theses Books
We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!

To the bibliography