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Relevant bibliographies by topics / Lipidy stratum corneum

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Academic literature on the topic 'Lipidy stratum corneum'

Author: Grafiati

Published: 4 June 2021

Last updated: 2 February 2022

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Journal articles on the topic "Lipidy stratum corneum"

1

Vávrová, K., A. Kováčik, and L. Opálka. "Ceramides in the skin barrier." European Pharmaceutical Journal 64, no. 2 (November 27, 2017): 28–35. http://dx.doi.org/10.1515/afpuc-2017-0004.

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AbstractThe skin barrier, which is essential for human survival on dry land, is located in the uppermost skin layer, the stratum corneum. The stratum corneum consists of corneocytes surrounded by multilamellar lipid membranes that prevent excessive water loss from the body and entrance of undesired substances from the environment. To ensure this protective function, the composition and organization of the lipid membranes is highly specialized. The major skin barrier lipids are ceramides, fatty acids and cholesterol in an approximately equimolar ratio. With hundreds of molecular species of ceramide, skin barrier lipids are a highly complex mixture that complicate the investigation of its behaviour. In this minireview, the structures of the major skin barrier lipids, formation of the stratum corneum lipid membranes and their molecular organization are described.

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Inman, A. O., T. Olivry, S. M. Dunston, N. A. Monteiro-Riviere, and H. Gatto. "Electron Microscopic Observations of Stratum Corneum Intercellular Lipids in Normal and Atopic Dogs." Veterinary Pathology 38, no. 6 (November 2001): 720–23. http://dx.doi.org/10.1354/vp.38-6-720.

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The barrier function of mammalian skin is maintained by intercellular stratum corneum lipids. In human patients with atopic dermatitis, an abnormal lipid barrier results in dry skin and increased transepidermal water loss. At this time, it is not known if a defective lipid barrier is present in atopic dogs. Normal and atopic canine skin were postfixed in ruthenium tetroxide and studied using transmission electron microscopy to determine structural differences within stratum corneum lipids. Intercellular lipid lamellae were graded on a semiquantitative scale. The deposition of stratum corneum lipid lamellae in atopic canine skin appeared markedly heterogeneous compared with that seen in normal canine skin. When present, the lamellae often exhibited an abnormal structure. The continuity and thickness of the intercellular lipid lamellae were significantly less in nonlesional atopic than in normal canine skin. These preliminary observations suggest that the epidermal lipid barrier is defective in atopic canine skin. Additional studies are needed to further characterize the biochemical defect and to possibly correct it with nutritional and/or pharmacologic intervention.

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Das, Chinmay, and Peter D. Olmsted. "The physics of stratum corneum lipid membranes." Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences 374, no. 2072 (July 28, 2016): 20150126. http://dx.doi.org/10.1098/rsta.2015.0126.

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The stratum corneum (SC), the outermost layer of skin, comprises rigid corneocytes (keratin-filled dead cells) in a specialized lipid matrix. The continuous lipid matrix provides the main barrier against uncontrolled water loss and invasion of external pathogens. Unlike all other biological lipid membranes (such as intracellular organelles and plasma membranes), molecules in the SC lipid matrix show small hydrophilic groups and large variability in the length of the alkyl tails and in the numbers and positions of groups that are capable of forming hydrogen bonds. Molecular simulations provide a route for systematically probing the effects of each of these differences separately. In this article, we present the results from atomistic molecular dynamics of selected lipid bilayers and multi-layers to probe the effect of these polydispersities. We address the nature of the tail packing in the gel-like phase, the hydrogen bond network among head groups, the bending moduli expected for leaflets comprising SC lipids and the conformation of very long ceramide lipids in multi-bilayer lipid assemblies. This article is part of the themed issue ‘Soft interfacial materials: from fundamentals to formulation’.

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4

Lafleur, Michel. "Phase behaviour of model stratum corneum lipid mixtures: an infrared spectroscopy investigation." Canadian Journal of Chemistry 76, no. 11 (November 1, 1998): 1501–11. http://dx.doi.org/10.1139/v98-114.

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The stratum corneum, the top layer of the epidermis, is the material that constitutes the membrane enveloping our body. The lipids that are present are responsible for the permeability properties of the skin and, as a consequence, are essential to maintain the hydration of the internal components and to protect our body from external agents. In the present work, the mixing and the structural properties of model mixtures formed by the main lipids of the stratum corneum have been examined by infrared spectroscopy. The model is formed by an equimolar mixture of ceramides (type III), cholesterol, and perdeuterated palmitic acid. Binary mixtures as well as mixtures for which the ceramides were substituted by sphingomyelin, a ceramide precursor, have also been studied. The results indicate that the stratum corneum model mixture exhibits a rich polymorphism, ranging from crystalline domains with heterogeneous lipid composition and orthorhombic chain packing, to a fluid and homogeneous phase. To obtain this particular behaviour, the three components are essential and the specific role of each species is discussed. In addition, the results reveal that the homogeneous lipid distribution observed for temperatures higher than 70°C can be maintained at low temperatures, leading to the formation of a metastable phase. Several weeks are needed to obtain the thermodynamically stable phase if the sample is incubated at 5°C. However, it is rapidly induced by annealing the sample at 40°C.Key words: stratum corneum, lipid, infrared spectroscopy, ceramide.

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5

Schürer, N. Y., G. Plewig, and P. M. Elias. "Stratum corneum Lipid Function." Dermatology 183, no. 2 (1991): 77–94. http://dx.doi.org/10.1159/000247644.

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6

Wertz, Philip W. "Roles of Lipids in the Permeability Barriers of Skin and Oral Mucosa." International Journal of Molecular Sciences 22, no. 10 (May 15, 2021): 5229. http://dx.doi.org/10.3390/ijms22105229.

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PubMed searches reveal much literature regarding lipids in barrier function of skin and less literature on lipids in barrier function of the oral mucosa. In terrestrial mammals, birds, and reptiles, the skin’s permeability barrier is provided by ceramides, fatty acids, and cholesterol in the outermost layers of the epidermis, the stratum corneum. This layer consists of about 10–20 layers of cornified cells embedded in a lipid matrix. It effectively prevents loss of water and electrolytes from the underlying tissue, and it limits the penetration of potentially harmful substances from the environment. In the oral cavity, the regions of the gingiva and hard palate are covered by keratinized epithelia that much resemble the epidermis. The oral stratum corneum contains a lipid mixture similar to that in the epidermal stratum corneum but in lower amounts and is accordingly more permeable. The superficial regions of the nonkeratinized oral epithelia also provide a permeability barrier. These epithelial regions do contain ceramides, cholesterol, and free fatty acids, which may underlie barrier function. The oral epithelial permeability barriers primarily protect the underlying tissue by preventing the penetration of potentially toxic substances, including microbial products. Transdermal drug delivery, buccal absorption, and lipid-related disease are discussed.

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Jonca, Nathalie. "Ceramides metabolism and impaired epidermal barrier in cutaneous diseases and skin aging: focus on the role of the enzyme PNPLA1 in the synthesis of ω-O-acylceramides and its pathophysiological involvement in some forms of congenital ichthyoses." OCL 26 (2019): 17. http://dx.doi.org/10.1051/ocl/2019013.

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The outermost layer of the skin, the stratum corneum, is essential for the protective barrier functions of the skin. It results from the stacking of corneocytes, the dead flattened cells resulting from epidermal terminal differentiation of underlying living keratinocytes. The cornified lipid envelope, encapsulating corneocytes, and the extracellular mortar-like multilayered lipid matrix, called lamellae, are two crucial elements of the epidermal barrier. Stratum corneum extracellular lipids are mainly composed of ceramides, cholesterol and free fatty acids. Ceramides, and more specifically the epidermis specific ω-O-acylceramides, are essential for lipid-matrix organization into lamellae and formation of the corneocyte lipid envelope. Pathophysiological studies of inherited lipid metabolism disorders recently contributed to a better understanding of stratum corneum lipid metabolism. In the lab, our data from patients with Autosomal Recessive Congenital Ichthyosis and a murine knock-out model showed that the enzyme PNPLA1 is essential for the last step of synthesis of omega-O-acylceramides. Skin aging is a complex biological process caused by genetic and extrinsic factors e.g. sun exposure, smoke, and pollution. Aging skin is marked by a senescence-related decline in lipid and water content, which ultimately impairs epidermal barrier function. Thus, aged epidermis is prone to develop altered drug permeability, increased susceptibility to irritants contact dermatitis and severe xerosis. Ceramide deficiency may account, at least in part, for the dysfunction of the stratum corneum associated with ageing. Hence, treatments able to increase skin-ceramide levels could improve the epidermal barrier function in aged skin. Many animal testing and clinical trials are taken in that regard.

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Sahle, Fitsum F., Tsige Gebre-Mariam, Bodo Dobner, Johannes Wohlrab, and Reinhard H. H. Neubert. "Skin Diseases Associated with the Depletion of Stratum Corneum Lipids and Stratum Corneum Lipid Substitution Therapy." Skin Pharmacology and Physiology 28, no. 1 (2015): 42–55. http://dx.doi.org/10.1159/000360009.

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Wertz, Philip W. "Lipids and the Permeability and Antimicrobial Barriers of the Skin." Journal of Lipids 2018 (September 2, 2018): 1–7. http://dx.doi.org/10.1155/2018/5954034.

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The primary purpose of the epidermis of terrestrial vertebrates is to produce the stratum corneum, which serves as the interface between the organism and the environment. As such, the stratum corneum provides a permeability barrier which both limits water loss through the skin and provides a relatively tough permeability barrier. This provides for a degree of resistance to mechanical trauma and prevents or limits penetration of potentially harmful substances from the environment. The stratum corneum consists of an array of keratinized cells embedded in a lipid matrix. It is this intercellular lipid that determines the permeability of the stratum corneum. The main lipids here are ceramides, cholesterol, and fatty acids. In addition, the skin surface of mammals, including humans, is coated by a lipid film produced by sebaceous glands in the dermis and secreted through the follicles. Human sebum consists mainly of squalene, wax monoesters, and triglycerides with small proportions of cholesterol and cholesterol esters. As sebum passes through the follicles, some of the triglycerides are hydrolyzed by bacteria to liberate free fatty acids. Likewise, near the skin surface, where water becomes available, some of the ceramides are acted upon by an epithelial ceramidase to liberate sphingosine, dihydrosphingosine, and 6-hydroxysphingosine. Some of the free fatty acids, specifically lauric acid and sapienic acid, have been shown to have antibacterial, antifungal, and antiviral activity. Also, the long-chain bases have broad spectrum antibacterial activity.

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Becker, S. M., and A. V. Kuznetsov. "Local Temperature Rises Influence In Vivo Electroporation Pore Development: A Numerical Stratum Corneum Lipid Phase Transition Model." Journal of Biomechanical Engineering 129, no. 5 (March 7, 2007): 712–21. http://dx.doi.org/10.1115/1.2768380.

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Electroporation is an approach used to enhance transdermal transport of large molecules in which the skin is exposed to a series of electric pulses. Electroporation temporarily destabilizes the structure of the outer skin layer, the stratum corneum, by creating microscopic pores through which agents, ordinarily unable to pass into the skin, are able to pass through this outer barrier. Long duration electroporation pulses can cause localized temperature rises, which result in thermotropic phase transitions within the lipid bilayer matrix of the stratum corneum. This paper focuses on electroporation pore development resulting from localized Joule heating. This study presents a theoretical model of electroporation, which incorporates stratum corneum lipid melting with electrical and thermal energy equations. A transient finite volume model is developed representing electroporation of in vivo human skin, in which stratum corneum lipid phase transitions are modeled as a series of melting processes. The results confirm that applied voltage to the skin results in high current densities within the less resistive regions of the stratum corneum. The model captures highly localized Joule heating within the stratum corneum and subsequent temperature rises, which propagate radially outward. Electroporation pore development resulting from the decrease in resistance associated with lipid melting is captured by the lipid phase transition model. As the effective pore radius grows, current density and subsequent Joule heating values decrease.

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Dissertations / Theses on the topic "Lipidy stratum corneum"

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Raynal, Pierre. "Les lipides du stratum corneum : analyse qualitative." Paris 5, 1997. http://www.theses.fr/1997PA05P173.

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Evans, D. A. "Molecular dynamics simulations of skin lipids." Thesis, University of Bath, 1996. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.296332.

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Zellmer, Sebastian. "Lipid- und strahlungsinduzierte Störungen des humanen epidermalen Stratum corneums." [S.l.] : [s.n.], 2001. http://deposit.ddb.de/cgi-bin/dokserv?idn=962330396.

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Rogers, Julia Sarah. "The role of the stratum corneum lipids and enzymes in skin condition." Thesis, University College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.367557.

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Ribaud, Christèle. "Relations entre les proprietes structurales des lipides intercorneocytaires et la fonction barriere du stratum corneum." Paris 11, 1994. http://www.theses.fr/1994PA114833.

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6

Temeghe, Laurice. "Les lipides épidermiques." Paris 5, 1998. http://www.theses.fr/1998PA05P051.

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Zulian, Claudine. "Les lipides intercellulaires cutanés." Paris 5, 1995. http://www.theses.fr/1995PA05P210.

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Raudenkolb, Steve. "Untersuchungen zur strukturellen und physikochemischen Charakterisierung von Stratum corneum Lipiden und deren Mischsystemen." [S.l.] : [s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=967136067.

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Schönfelder, Ute. "Der Einfluss von Cholesterol auf die UV-induzierte Peroxidation der Lipide des menschlichen Stratum corneum." [S.l.] : [s.n.], 1999. http://deposit.ddb.de/cgi-bin/dokserv?idn=961409886.

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Fröhlich, Margret. "Elektronenmikroskopische und physikalische Untersuchungen an Hautmodellen aus humanen Stratum-corneum-Lipiden und topischen phospholipidhaltigen Wirkstoff-Formulierungen /." [S.l. : s.n.], 2000. http://www.gbv.de/dms/bs/toc/33748273X.pdf.

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Books on the topic "Lipidy stratum corneum"

1

Oldroyd, Jon Richard. Phase behaviour and physical properties of stratum corneum lipids and lipid models. Salford: University of Salford, 1994.

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Book chapters on the topic "Lipidy stratum corneum"

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Jungersted, Jakob Mutanu. "Stratum Corneum Lipids and Filaggrin." In Filaggrin, 23–26. Berlin, Heidelberg: Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-642-54379-1_3.

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Mojumdar, Enamul Haque, and Joke A. Bouwstra. "Stratum Corneum Lipid Composition and Organization." In Cosmetic Formulation, 47–60. Boca Raton, Florida : CRC Press, 2019.: CRC Press, 2019. http://dx.doi.org/10.1201/9780429190674-3.

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3

Friberg, Stig E., and Zhuning Ma. "Simple Models for the Stratum Corneum Lipids." In Advances in the Applications of Membrane-Mimetic Chemistry, 41–49. Boston, MA: Springer US, 1994. http://dx.doi.org/10.1007/978-1-4615-2580-6_4.

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4

Wertz, P. W. "Integral lipids of hair and stratum corneum." In Formation and Structure of Human Hair, 227–37. Basel: Birkhäuser Basel, 1997. http://dx.doi.org/10.1007/978-3-0348-9223-0_7.

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Rigopoulos, Dimitrios, and Ekaterini Tiligada. "Stratum Corneum Lipids and Water-Holding Capacity." In Dermatoanthropology of Ethnic Skin and Hair, 63–73. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-53961-4_6.

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Wartewig, Siegfried, Reinhard Neubert, and Willi Rettig. "Thermotropic phase behaviour of binary mixtures of stratum corneum lipids." In Spectroscopy of Biological Molecules: New Directions, 355–56. Dordrecht: Springer Netherlands, 1999. http://dx.doi.org/10.1007/978-94-011-4479-7_157.

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7

Lévêque, J. L., and L. Rasseneur. "Mechanical properties of stratum corneum: influence of water and lipids." In The Physical Nature of the Skin, 155–61. Dordrecht: Springer Netherlands, 1988. http://dx.doi.org/10.1007/978-94-009-1291-5_17.

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8

Nakagawa, Kouichi. "Structure of Stratum Corneum Lipid Studied by Electron Paramagnetic Resonance." In Textbook of Aging Skin, 1155–70. Berlin, Heidelberg: Springer Berlin Heidelberg, 2016. http://dx.doi.org/10.1007/978-3-662-47398-6_70.

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Nakagawa, Kouichi. "Structure of Stratum Corneum Lipid Studied by Electron Paramagnetic Resonance." In Textbook of Aging Skin, 1–16. Berlin, Heidelberg: Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-642-27814-3_70-2.

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Nakagawa, Kouichi. "Structure of Stratum Corneum Lipid Studied by Electron Paramagnetic Resonance." In Textbook of Aging Skin, 725–33. Berlin, Heidelberg: Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-540-89656-2_70.

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Conference papers on the topic "Lipidy stratum corneum"

1

Huzil, J. Torin, Siv Sivaloganathan, Mohammad Kohandel, Marianna Foldvari, Ilias Kotsireas, Roderick Melnik, and Brian West. "Modeling the Effects of Lipid Composition on Stratum Corneum Bilayers Using Molecular Dynamics Simulations." In ADVANCES IN MATHEMATICAL AND COMPUTATIONAL METHODS: ADDRESSING MODERN CHALLENGES OF SCIENCE, TECHNOLOGY, AND SOCIETY. AIP, 2011. http://dx.doi.org/10.1063/1.3663488.

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Varghese, Babu, Anna A. Ezerskaia, H. Paul Urbach, and Silvania F. Pereira. "Depth resolved quantitative profiling of stratum corneum lipids and water content using short-wave infrared spectroscopy." In Photonics in Dermatology and Plastic Surgery 2018, edited by Bernard Choi and Haishan Zeng. SPIE, 2018. http://dx.doi.org/10.1117/12.2291896.

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