Log in

Relevant bibliographies by topics / Lipidy stratum corneum / Journal articles

To see the other types of publications on this topic, follow the link: Lipidy stratum corneum.

Journal articles on the topic 'Lipidy stratum corneum'

Author: Grafiati

Published: 4 June 2021

Last updated: 2 February 2022

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'Lipidy stratum corneum.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Vávrová, K., A. Kováčik, and L. Opálka. "Ceramides in the skin barrier." European Pharmaceutical Journal 64, no. 2 (November 27, 2017): 28–35. http://dx.doi.org/10.1515/afpuc-2017-0004.

Full text

Abstract:

AbstractThe skin barrier, which is essential for human survival on dry land, is located in the uppermost skin layer, the stratum corneum. The stratum corneum consists of corneocytes surrounded by multilamellar lipid membranes that prevent excessive water loss from the body and entrance of undesired substances from the environment. To ensure this protective function, the composition and organization of the lipid membranes is highly specialized. The major skin barrier lipids are ceramides, fatty acids and cholesterol in an approximately equimolar ratio. With hundreds of molecular species of ceramide, skin barrier lipids are a highly complex mixture that complicate the investigation of its behaviour. In this minireview, the structures of the major skin barrier lipids, formation of the stratum corneum lipid membranes and their molecular organization are described.

APA, Harvard, Vancouver, ISO, and other styles

2

Inman, A. O., T. Olivry, S. M. Dunston, N. A. Monteiro-Riviere, and H. Gatto. "Electron Microscopic Observations of Stratum Corneum Intercellular Lipids in Normal and Atopic Dogs." Veterinary Pathology 38, no. 6 (November 2001): 720–23. http://dx.doi.org/10.1354/vp.38-6-720.

Full text

Abstract:

The barrier function of mammalian skin is maintained by intercellular stratum corneum lipids. In human patients with atopic dermatitis, an abnormal lipid barrier results in dry skin and increased transepidermal water loss. At this time, it is not known if a defective lipid barrier is present in atopic dogs. Normal and atopic canine skin were postfixed in ruthenium tetroxide and studied using transmission electron microscopy to determine structural differences within stratum corneum lipids. Intercellular lipid lamellae were graded on a semiquantitative scale. The deposition of stratum corneum lipid lamellae in atopic canine skin appeared markedly heterogeneous compared with that seen in normal canine skin. When present, the lamellae often exhibited an abnormal structure. The continuity and thickness of the intercellular lipid lamellae were significantly less in nonlesional atopic than in normal canine skin. These preliminary observations suggest that the epidermal lipid barrier is defective in atopic canine skin. Additional studies are needed to further characterize the biochemical defect and to possibly correct it with nutritional and/or pharmacologic intervention.

APA, Harvard, Vancouver, ISO, and other styles

3

Das, Chinmay, and Peter D. Olmsted. "The physics of stratum corneum lipid membranes." Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences 374, no. 2072 (July 28, 2016): 20150126. http://dx.doi.org/10.1098/rsta.2015.0126.

Full text

Abstract:

The stratum corneum (SC), the outermost layer of skin, comprises rigid corneocytes (keratin-filled dead cells) in a specialized lipid matrix. The continuous lipid matrix provides the main barrier against uncontrolled water loss and invasion of external pathogens. Unlike all other biological lipid membranes (such as intracellular organelles and plasma membranes), molecules in the SC lipid matrix show small hydrophilic groups and large variability in the length of the alkyl tails and in the numbers and positions of groups that are capable of forming hydrogen bonds. Molecular simulations provide a route for systematically probing the effects of each of these differences separately. In this article, we present the results from atomistic molecular dynamics of selected lipid bilayers and multi-layers to probe the effect of these polydispersities. We address the nature of the tail packing in the gel-like phase, the hydrogen bond network among head groups, the bending moduli expected for leaflets comprising SC lipids and the conformation of very long ceramide lipids in multi-bilayer lipid assemblies. This article is part of the themed issue ‘Soft interfacial materials: from fundamentals to formulation’.

APA, Harvard, Vancouver, ISO, and other styles

4

Lafleur, Michel. "Phase behaviour of model stratum corneum lipid mixtures: an infrared spectroscopy investigation." Canadian Journal of Chemistry 76, no. 11 (November 1, 1998): 1501–11. http://dx.doi.org/10.1139/v98-114.

Full text

Abstract:

The stratum corneum, the top layer of the epidermis, is the material that constitutes the membrane enveloping our body. The lipids that are present are responsible for the permeability properties of the skin and, as a consequence, are essential to maintain the hydration of the internal components and to protect our body from external agents. In the present work, the mixing and the structural properties of model mixtures formed by the main lipids of the stratum corneum have been examined by infrared spectroscopy. The model is formed by an equimolar mixture of ceramides (type III), cholesterol, and perdeuterated palmitic acid. Binary mixtures as well as mixtures for which the ceramides were substituted by sphingomyelin, a ceramide precursor, have also been studied. The results indicate that the stratum corneum model mixture exhibits a rich polymorphism, ranging from crystalline domains with heterogeneous lipid composition and orthorhombic chain packing, to a fluid and homogeneous phase. To obtain this particular behaviour, the three components are essential and the specific role of each species is discussed. In addition, the results reveal that the homogeneous lipid distribution observed for temperatures higher than 70°C can be maintained at low temperatures, leading to the formation of a metastable phase. Several weeks are needed to obtain the thermodynamically stable phase if the sample is incubated at 5°C. However, it is rapidly induced by annealing the sample at 40°C.Key words: stratum corneum, lipid, infrared spectroscopy, ceramide.

APA, Harvard, Vancouver, ISO, and other styles

5

Schürer, N. Y., G. Plewig, and P. M. Elias. "Stratum corneum Lipid Function." Dermatology 183, no. 2 (1991): 77–94. http://dx.doi.org/10.1159/000247644.

Full text

APA, Harvard, Vancouver, ISO, and other styles

6

Wertz, Philip W. "Roles of Lipids in the Permeability Barriers of Skin and Oral Mucosa." International Journal of Molecular Sciences 22, no. 10 (May 15, 2021): 5229. http://dx.doi.org/10.3390/ijms22105229.

Full text

Abstract:

PubMed searches reveal much literature regarding lipids in barrier function of skin and less literature on lipids in barrier function of the oral mucosa. In terrestrial mammals, birds, and reptiles, the skin’s permeability barrier is provided by ceramides, fatty acids, and cholesterol in the outermost layers of the epidermis, the stratum corneum. This layer consists of about 10–20 layers of cornified cells embedded in a lipid matrix. It effectively prevents loss of water and electrolytes from the underlying tissue, and it limits the penetration of potentially harmful substances from the environment. In the oral cavity, the regions of the gingiva and hard palate are covered by keratinized epithelia that much resemble the epidermis. The oral stratum corneum contains a lipid mixture similar to that in the epidermal stratum corneum but in lower amounts and is accordingly more permeable. The superficial regions of the nonkeratinized oral epithelia also provide a permeability barrier. These epithelial regions do contain ceramides, cholesterol, and free fatty acids, which may underlie barrier function. The oral epithelial permeability barriers primarily protect the underlying tissue by preventing the penetration of potentially toxic substances, including microbial products. Transdermal drug delivery, buccal absorption, and lipid-related disease are discussed.

APA, Harvard, Vancouver, ISO, and other styles

7

Jonca, Nathalie. "Ceramides metabolism and impaired epidermal barrier in cutaneous diseases and skin aging: focus on the role of the enzyme PNPLA1 in the synthesis of ω-O-acylceramides and its pathophysiological involvement in some forms of congenital ichthyoses." OCL 26 (2019): 17. http://dx.doi.org/10.1051/ocl/2019013.

Full text

Abstract:

The outermost layer of the skin, the stratum corneum, is essential for the protective barrier functions of the skin. It results from the stacking of corneocytes, the dead flattened cells resulting from epidermal terminal differentiation of underlying living keratinocytes. The cornified lipid envelope, encapsulating corneocytes, and the extracellular mortar-like multilayered lipid matrix, called lamellae, are two crucial elements of the epidermal barrier. Stratum corneum extracellular lipids are mainly composed of ceramides, cholesterol and free fatty acids. Ceramides, and more specifically the epidermis specific ω-O-acylceramides, are essential for lipid-matrix organization into lamellae and formation of the corneocyte lipid envelope. Pathophysiological studies of inherited lipid metabolism disorders recently contributed to a better understanding of stratum corneum lipid metabolism. In the lab, our data from patients with Autosomal Recessive Congenital Ichthyosis and a murine knock-out model showed that the enzyme PNPLA1 is essential for the last step of synthesis of omega-O-acylceramides. Skin aging is a complex biological process caused by genetic and extrinsic factors e.g. sun exposure, smoke, and pollution. Aging skin is marked by a senescence-related decline in lipid and water content, which ultimately impairs epidermal barrier function. Thus, aged epidermis is prone to develop altered drug permeability, increased susceptibility to irritants contact dermatitis and severe xerosis. Ceramide deficiency may account, at least in part, for the dysfunction of the stratum corneum associated with ageing. Hence, treatments able to increase skin-ceramide levels could improve the epidermal barrier function in aged skin. Many animal testing and clinical trials are taken in that regard.

APA, Harvard, Vancouver, ISO, and other styles

8

Sahle, Fitsum F., Tsige Gebre-Mariam, Bodo Dobner, Johannes Wohlrab, and Reinhard H. H. Neubert. "Skin Diseases Associated with the Depletion of Stratum Corneum Lipids and Stratum Corneum Lipid Substitution Therapy." Skin Pharmacology and Physiology 28, no. 1 (2015): 42–55. http://dx.doi.org/10.1159/000360009.

Full text

APA, Harvard, Vancouver, ISO, and other styles

9

Wertz, Philip W. "Lipids and the Permeability and Antimicrobial Barriers of the Skin." Journal of Lipids 2018 (September 2, 2018): 1–7. http://dx.doi.org/10.1155/2018/5954034.

Full text

Abstract:

The primary purpose of the epidermis of terrestrial vertebrates is to produce the stratum corneum, which serves as the interface between the organism and the environment. As such, the stratum corneum provides a permeability barrier which both limits water loss through the skin and provides a relatively tough permeability barrier. This provides for a degree of resistance to mechanical trauma and prevents or limits penetration of potentially harmful substances from the environment. The stratum corneum consists of an array of keratinized cells embedded in a lipid matrix. It is this intercellular lipid that determines the permeability of the stratum corneum. The main lipids here are ceramides, cholesterol, and fatty acids. In addition, the skin surface of mammals, including humans, is coated by a lipid film produced by sebaceous glands in the dermis and secreted through the follicles. Human sebum consists mainly of squalene, wax monoesters, and triglycerides with small proportions of cholesterol and cholesterol esters. As sebum passes through the follicles, some of the triglycerides are hydrolyzed by bacteria to liberate free fatty acids. Likewise, near the skin surface, where water becomes available, some of the ceramides are acted upon by an epithelial ceramidase to liberate sphingosine, dihydrosphingosine, and 6-hydroxysphingosine. Some of the free fatty acids, specifically lauric acid and sapienic acid, have been shown to have antibacterial, antifungal, and antiviral activity. Also, the long-chain bases have broad spectrum antibacterial activity.

APA, Harvard, Vancouver, ISO, and other styles

10

Becker, S. M., and A. V. Kuznetsov. "Local Temperature Rises Influence In Vivo Electroporation Pore Development: A Numerical Stratum Corneum Lipid Phase Transition Model." Journal of Biomechanical Engineering 129, no. 5 (March 7, 2007): 712–21. http://dx.doi.org/10.1115/1.2768380.

Full text

Abstract:

Electroporation is an approach used to enhance transdermal transport of large molecules in which the skin is exposed to a series of electric pulses. Electroporation temporarily destabilizes the structure of the outer skin layer, the stratum corneum, by creating microscopic pores through which agents, ordinarily unable to pass into the skin, are able to pass through this outer barrier. Long duration electroporation pulses can cause localized temperature rises, which result in thermotropic phase transitions within the lipid bilayer matrix of the stratum corneum. This paper focuses on electroporation pore development resulting from localized Joule heating. This study presents a theoretical model of electroporation, which incorporates stratum corneum lipid melting with electrical and thermal energy equations. A transient finite volume model is developed representing electroporation of in vivo human skin, in which stratum corneum lipid phase transitions are modeled as a series of melting processes. The results confirm that applied voltage to the skin results in high current densities within the less resistive regions of the stratum corneum. The model captures highly localized Joule heating within the stratum corneum and subsequent temperature rises, which propagate radially outward. Electroporation pore development resulting from the decrease in resistance associated with lipid melting is captured by the lipid phase transition model. As the effective pore radius grows, current density and subsequent Joule heating values decrease.

APA, Harvard, Vancouver, ISO, and other styles

11

Muñoz-Garcia, Agustí, and Joseph B. Williams. "Cutaneous Water Loss and Lipids of the Stratum Corneum in Dusky Antbirds, a Lowland Tropical Bird." Condor 109, no. 1 (February 1, 2007): 59–66. http://dx.doi.org/10.1093/condor/109.1.59.

Full text

Abstract:

Abstract Abstract The stratum corneum, the outer layer of the epidermis, consists of flattened cells embedded in a matrix of lipids, primarily cholesterol, free fatty acids, ceramides, and cerebrosides. The stratum corneum forms a barrier to water vapor diffusion through the skin. In birds, the skin limits excessive water loss at thermoneutral temperatures, but also serves as a vehicle for thermoregulation during episodes of heat stress. We measured total evaporative water loss, cutaneous water loss, and lipids in the stratum corneum in Dusky Antbirds (Cercomacra tyrannina), the first such measurements ever made for birds living in tropical rain forests. We predicted that these birds would have high rates of cutaneous water loss because of their need to thermoregulate rather than to conserve water. We found that Dusky Antbirds lose twice as much water through their skin as birds from temperate environments. We also hypothesized that the proportion of cerebrosides in the stratum corneum would increase relative to that of ceramides if Dusky Antbirds use their skin as a thermoregulatory organ. However, we found that Dusky Antbirds did not show different proportions of ceramides and cerebrosides in the stratum corneum than other species of birds. We also found that Dusky Antbirds had low amounts of free fatty acids in their stratum corneum. Overall, our data support the idea that the interactions of the lipids in the stratum corneum may play an important role in determining rates of water vapor diffusion through the skin.

APA, Harvard, Vancouver, ISO, and other styles

12

Wertz, Philip W. "Stratum corneum Lipids and Water." Exogenous Dermatology 3, no. 2 (2004): 53–56. http://dx.doi.org/10.1159/000086155.

Full text

APA, Harvard, Vancouver, ISO, and other styles

13

Ongpipattanakul, Boonsri, Michael L. Francoeur, and Russell O. Potts. "Polymorphism in stratum corneum lipids." Biochimica et Biophysica Acta (BBA) - Biomembranes 1190, no. 1 (February 1994): 115–22. http://dx.doi.org/10.1016/0005-2736(94)90040-x.

Full text

APA, Harvard, Vancouver, ISO, and other styles

14

Lymberopoulos, A., C. Demopoulou, M. Kyriazi, MS Katsarou, N. Demertzis, S. Hatziandoniou, H. Maswadeh, et al. "Liposome percutaneous penetration in vivo." Toxicology Research and Application 1 (January 1, 2017): 239784731772319. http://dx.doi.org/10.1177/2397847317723196.

Full text

Abstract:

Objectives: Liposomes are reported as penetration enhancers for dermal and transdermal delivery. However, little is known about their percutaneous penetration and as to at which level they deliver encapsulated drugs. The penetration of multilamellar vesicles (MLVs) and small unilamellar vesicles (SUVs), in comparison to one of their lipid components, was investigated. Methods: Using the fluorescent lipid, Lissamine Rhodamine B-PE (R), as a constituent, MLV and SUV liposomes were prepared, tested, and R, MLV, or SUV were applied in vivo on the back of hairless mice. Absorption of each was evaluated at the levels of stratum corneum, living skin, and blood by fluorometry. Results: Penetration of the lipid R in stratum corneum in the nonliposomal form exceeded that in the liposomal form and only R penetrates the living skin in a statistically significant manner. No statistical significant absorption into blood was observed with either form. Conclusions: Liposomes size did not play an important role in penetration to stratum corneum. The lipid constituent in the nonliposomal form penetrated at higher rates into stratum corneum and living skin. Even though these liposomes entered stratum corneum, they were not significantly absorbed into viable skin or blood.

APA, Harvard, Vancouver, ISO, and other styles

15

Sigg, Melanie, and Rolf Daniels. "Impact of Alkanediols on Stratum Corneum Lipids and Triamcinolone Acetonide Skin Penetration." Pharmaceutics 13, no. 9 (September 11, 2021): 1451. http://dx.doi.org/10.3390/pharmaceutics13091451.

Full text

Abstract:

Alkanediols are widely used as multifunctional ingredients in dermal formulations. In addition to their preservative effect, considering their possible impact on drug penetration is also essential for their use. In the present study, the influence of 2-methyl-2,4-pentanediol, 1,2-pentanediol, 1,2-hexanediol and 1,2-octanediol on the skin penetration of triamcinolone acetonide from four different semisolid formulations was investigated. Furthermore, confocal Raman spectroscopy measurements were performed to examine the influence of the alkanediols on stratum corneum lipid content and order. Alkanediols were found to increase the penetration of triamcinolone acetonide. However, the extent depends strongly on the formulation used. In certain formulations, 1,2-pentanediol showed the highest effect, while in others the penetration-enhancing effect increased with the alkyl chain length of the alkanediol used. None of the tested alkanediols extracted lipids from the stratum corneum nor reduced its thickness. Notwithstanding the above, the longer-chained alkanediols cause the lipids to be converted to a more disordered state, which favors drug penetration. This behavior could not be detected for the shorter-chained alkanediols. Therefore, their penetration-enhancing effect is supposed to be related to an interaction with the hydrophilic regions of the stratum corneum.

APA, Harvard, Vancouver, ISO, and other styles

16

Ibrahim, Sarah A., and S. Kevin Li. "Chemical enhancer solubility in human stratum corneum lipids and enhancer mechanism of action on stratum corneum lipid domain." International Journal of Pharmaceutics 383, no. 1-2 (January 2010): 89–98. http://dx.doi.org/10.1016/j.ijpharm.2009.09.014.

Full text

APA, Harvard, Vancouver, ISO, and other styles

17

Zhang, Wen-Jun, Jiao-Ying Wang, Hui Li, Xin He, Run-Qi Zhang, Chun-Feng Zhang, Fei Li, Zhong-Lin Yang, Chong-Zhi Wang, and Chun-Su Yuan. "Novel Application of Natural Anisole Compounds as Enhancers for Transdermal Delivery of Ligustrazine." American Journal of Chinese Medicine 43, no. 06 (January 2015): 1231–46. http://dx.doi.org/10.1142/s0192415x15500706.

Full text

Abstract:

To improve the transdermal delivery of ligustrazine, Foeniculum vulgare food origin anisole compounds were employed as promoters. Transdermal fluxes of ligustrazine were determined by Franz-type diffusion cells. Fourier transform-infrared (FT-IR) spectra were used to detect the biophysical changes of the stratum corneum and to explore the mechanism of permeation enhancement. A scanning electron microscope (SEM) was used to monitor the morphological changes of the skin. Among the three anisoles, anisic acid increased the penetration flux of ligustrazine significantly. The ligustrazine flux with anisic acid (11.9 μg/cm2/h) was higher than that any other group (p < 0.05). Spectra observations revealed that these anisole enhancers were able to disturb and extract the stratum corneum lipids. In addition, apparent density was used to describe the desquamation extent of the scutella. Multiple mechanisms are involved in the permeation enhancement of ligustrazine, including disturbing and extracting stratum corneum lipid, forming a competitive hydrogen bond. All data suggested that anisole compounds could be a group of safe and active penetration enhancers for transdermal delivery of ligustrazine.

APA, Harvard, Vancouver, ISO, and other styles

18

Saint-Léger, D., A. M. François, J. L. Lévêque, T. J. Stoudemayer, A. M. Kligman, and G. Grove. "Stratum corneum Lipids in Skin Xerosis." Dermatology 178, no. 3 (1989): 151–55. http://dx.doi.org/10.1159/000248415.

Full text

APA, Harvard, Vancouver, ISO, and other styles

19

Svane-Knudsen, Viggo. "Stratum Corneum Barrier Lipids in Cholesteatoma." Acta Oto-Laryngologica 120, no. 543 (January 2000): 139–42. http://dx.doi.org/10.1080/000164800454224.

Full text

APA, Harvard, Vancouver, ISO, and other styles

20

Friberg, Stig E., Lisa Goldsmith, Hamdan Suhaimi, and Linda D. Rhein. "Surfactants and the stratum corneum lipids." Colloids and Surfaces 30, no. 1 (January 1987): 1–12. http://dx.doi.org/10.1016/0166-6622(87)80200-7.

Full text

APA, Harvard, Vancouver, ISO, and other styles

21

Sugino, Kiyoko, Genii Imokawa, and Howard I. Maibach. "Ethnic difference of varied stratum corneum function in relation to stratum corneum lipids." Journal of Dermatological Science 6, no. 1 (August 1993): 108. http://dx.doi.org/10.1016/0923-1811(93)91343-s.

Full text

APA, Harvard, Vancouver, ISO, and other styles

22

Bouwstra, J. A., G. S. Gooris, W. Bras, and D. T. Downing. "Lipid organization in pig stratum corneum." Journal of Lipid Research 36, no. 4 (April 1995): 685–95. http://dx.doi.org/10.1016/s0022-2275(20)40054-9.

Full text

APA, Harvard, Vancouver, ISO, and other styles

23

Sarifuddin, Nurhidayah, Widji Soerarti, and Noorma Rosita. "Preparation and Characteristics of NLC Coenzym Q10 with A Combination of Hyaluronic Acid." Health Notions 3, no. 1 (January 31, 2019): 32–36. http://dx.doi.org/10.33846/hn.v3i1.250.

Full text

Abstract:

Coenzyme Q10, often also known as ubiquinone, coenzyme Q10 or Q10, is soluble in lipids and is naturally present in plants, animals and in mitochondria. Coenzyme Q10 functions as an antioxidant that can protect the body from damage caused by free radicals. Hyaluronic acid is known as a hydrophilic polymer derived from polysaccharides which has the ability to increase percutaneous penetration by changing the composition of tightly arranged stratum corneum cells to increase the permeability of the skin. Nanostructured Lipid Carrier is a modification of the SLN system, consisting of a mixture of solid and liquid lipids (oil), stabilized by aqueous surfactant solution, is one method to increase drug penetration through the stratum corneum because it has several advantages. The purpose of this study was to see the effect of adding hyaluronic acid to the characteristics of the Nanostructure Lipid Carrier (NLC) as anti aging. Examination of characteristics including organoletis, pH, particle size and polidispersity index was carried out. The results of organoleptic NLC coenzym Q10-HA examination obtained dark orange color, liquid consistency, lipid efficacy odor and soft texture. The pH measurement results of the preparation ranged from 5.05-5.23. The results of the particle size examination ranged from 267-128 nm and the particle size distribution ranged between 0.308-0.200 Keywords: Coenzym Q10, Hyaluronic acid , NLC

APA, Harvard, Vancouver, ISO, and other styles

24

Mojumdar, E. H., G. S. Gooris, and J. A. Bouwstra. "Phase behavior of skin lipid mixtures: the effect of cholesterol on lipid organization." Soft Matter 11, no. 21 (2015): 4326–36. http://dx.doi.org/10.1039/c4sm02786h.

Full text

APA, Harvard, Vancouver, ISO, and other styles

25

Blume, Alfred, Michael Jansen, Miklos Ghyczy, and J. Gareiss. "Interaction of phospholipid liposomes with lipid model mixtures for stratum corneum lipids." International Journal of Pharmaceutics 99, no. 2-3 (October 1993): 219–28. http://dx.doi.org/10.1016/0378-5173(93)90364-l.

Full text

APA, Harvard, Vancouver, ISO, and other styles

26

Tsai, Jui-Chen, Yu-Li Lo, Ching-Yu Lin, Hamm-Ming Sheu, and Jui-Che Lin. "Feasibility of rapid quantitation of stratum corneum lipid content by Fourier transform infrared spectrometry." Spectroscopy 18, no. 3 (2004): 423–31. http://dx.doi.org/10.1155/2004/401015.

Full text

Abstract:

The permeability barrier of skin resides in the stratum corneum, and its properties are mediated by a series of lipid multilayers, enriched in ceramides, cholesterol, and free fatty acids, segregated within the stratum corneum (SC) interstices. SC lipid content is usually determined by gravimetric methods in conjunction with high performance thin layer chromatography, but these methods are time‒consuming and involve hazardous solvents. The objective of the present study was to develop a method of measuring SC lipid content by Fourier transform infrared spectrometry (FTIR) that is fast and requires no solvents. The IR spectra of isolated porcine SC sheets were recorded using a FTIR spectrometer. SC lipid content was determined by gravimetric methods using chloroform–methanol extraction. The peak area of both the CH2symmetric (2850 cm−1) and asymmetric (2920 cm−1) stretching bands in the IR spectra of progressively solvent‒extracted porcine SC sheets decreased with increasing amount of SC lipids removed. When spectral analysis was performed by curve‒fitting using GRAMS/32 software between 3000 to 2800 cm−1, peak area ratios of CH2to CH3asymmetric stretching bands in the IR spectra of 46 isolated porcine SC samples were correlated to SC lipid content (R2=0.90), with the standard error of measurement of 1.91%. The study demonstrated the feasibility of using FTIR technique to rapidly and accurately measure SC lipid content.

APA, Harvard, Vancouver, ISO, and other styles

27

SAKAMOTO, Kazutami. "Skin Barrier Function of Stratum Corneum Lipids." Oleoscience 17, no. 11 (2017): 539–48. http://dx.doi.org/10.5650/oleoscience.17.539.

Full text

APA, Harvard, Vancouver, ISO, and other styles

28

Wertz, Philip W., Kathi C. Madison, and Donald T. Downing. "Covalently Bound Lipids of Human Stratum Corneum." Journal of Investigative Dermatology 92, no. 1 (January 1989): 109–11. http://dx.doi.org/10.1111/1523-1747.ep13071317.

Full text

APA, Harvard, Vancouver, ISO, and other styles

29

Wertz, Philip W., William Abraham, Lukas Landmann, and Donald T. Downing. "Preparation of Liposomes from Stratum Corneum Lipids." Journal of Investigative Dermatology 87, no. 5 (November 1986): 582–84. http://dx.doi.org/10.1111/1523-1747.ep12455832.

Full text

APA, Harvard, Vancouver, ISO, and other styles

30

Friberg, Stig E., Hamdan Suhaimi, Lisa B. Goldsmith, and Linda L. Rhein. "STRATUM CORNEUM LIPIDS IN A MODEL STRUCTURE." Journal of Dispersion Science and Technology 9, no. 4 (January 1988): 371–89. http://dx.doi.org/10.1080/01932698808943996.

Full text

APA, Harvard, Vancouver, ISO, and other styles

31

Long, S. A., P. W. Wertz, J. S. Strauss, and D. T. Downing. "Human stratum corneum polar lipids and desquamation." Archives of Dermatological Research 277, no. 4 (1985): 284–87. http://dx.doi.org/10.1007/bf00509081.

Full text

APA, Harvard, Vancouver, ISO, and other styles

32

Rousseau, Marthe, Laurent Bédouet, Elian Lati, Philippe Gasser, Karine Le Ny, and Evelyne Lopez. "Restoration of stratum corneum with nacre lipids." Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology 145, no. 1 (September 2006): 1–9. http://dx.doi.org/10.1016/j.cbpb.2006.06.012.

Full text

APA, Harvard, Vancouver, ISO, and other styles

33

Silva, C. L., D. Topgaard, V. Kocherbitov, J. J. S. Sousa, A. A. C. C. Pais, and E. Sparr. "Stratum corneum hydration: Phase transformations and mobility in stratum corneum, extracted lipids and isolated corneocytes." Biochimica et Biophysica Acta (BBA) - Biomembranes 1768, no. 11 (November 2007): 2647–59. http://dx.doi.org/10.1016/j.bbamem.2007.05.028.

Full text

APA, Harvard, Vancouver, ISO, and other styles

34

Lasch, Juergen, Ute Schmitt, Brigitte Sternberg, and Rolf Schubert. "Human Stratum Corneum Lipid-Based Liposomes (hSCLLs)." Journal of Liposome Research 4, no. 1 (January 1994): 93–106. http://dx.doi.org/10.3109/08982109409037031.

Full text

APA, Harvard, Vancouver, ISO, and other styles

35

Golden, Guia M., Donald B. Guzek, Richard R. Harris, James E. McKie, and Russell O. Potts. "Lipid Thermotropic Transitions in Human Stratum Corneum." Journal of Investigative Dermatology 86, no. 3 (March 1986): 255–59. http://dx.doi.org/10.1111/1523-1747.ep12285373.

Full text

APA, Harvard, Vancouver, ISO, and other styles

36

Das, Chinmay, Massimo G. Noro, and Peter D. Olmsted. "Simulation Studies of Stratum Corneum Lipid Mixtures." Biophysical Journal 97, no. 7 (October 2009): 1941–51. http://dx.doi.org/10.1016/j.bpj.2009.06.054.

Full text

APA, Harvard, Vancouver, ISO, and other styles

37

Krill, Steven L., Kristine Knutson, and William I. Higuchi. "The stratum corneum lipid thermotropic phase behavior." Biochimica et Biophysica Acta (BBA) - Biomembranes 1112, no. 2 (December 1992): 281–86. http://dx.doi.org/10.1016/0005-2736(92)90403-9.

Full text

APA, Harvard, Vancouver, ISO, and other styles

38

Yamamoto, A., S. Serizawa, M. Ito, and Y. Sato. "Stratum corneum lipid abnormalities in atopic dermatitis." Archives of Dermatological Research 283, no. 4 (1991): 219–23. http://dx.doi.org/10.1007/bf01106105.

Full text

APA, Harvard, Vancouver, ISO, and other styles

39

Tokudome, Yoshihiro. "Influence of Oral Administration of Lactic Acid Bacteria Metabolites on Skin Barrier Function and Water Content in a Murine Model of Atopic Dermatitis." Nutrients 10, no. 12 (December 1, 2018): 1858. http://dx.doi.org/10.3390/nu10121858.

Full text

Abstract:

The effects of orally administered lactic acid bacteria metabolites on skin were studied using an atopic dermatitis-like murine model generated by feeding HR-AD to mice. Lactic acid bacteria metabolites were obtained by inoculating and culturing soy milk with 35 strains of 16 species of lactic acid bacteria. The atopic dermatitis-like murine model was generated by feeding HR-AD to HR-1 mice for 40 days. The skin condition of HR-AD-fed mice worsened compared with normal mice, showing reduced water content in the stratum corneum, increased transepidermal water loss (TEWL), reduced ceramide AP content in the stratum corneum, and increased epidermis thickness. When HR-AD-fed mice were orally administered a raw liquid containing lactic acid bacteria metabolites, water content in the stratum corneum, TEWL, ceramide AP content in the stratum corneum, and epidermis thickness improved. To determine the active components responsible for these effects, filtrate, residue, and lipid components extracted from the raw liquid containing lactic acid bacteria metabolites were examined. While water-soluble components and residue obtained after filtration had no effects, the lipid fraction showed similar effects to the raw liquid. These findings suggest that lactic acid bacteria metabolites improve skin injury in an atopic dermatitis-like murine model.

APA, Harvard, Vancouver, ISO, and other styles

40

Pietrzak, Aldona, Anna Michalak-Stoma, Grażyna Chodorowska, and Jacek C. Szepietowski. "Lipid Disturbances in Psoriasis: An Update." Mediators of Inflammation 2010 (2010): 1–13. http://dx.doi.org/10.1155/2010/535612.

Full text

Abstract:

Psoriasis is a common disease with the population prevalence ranging from 2% to 3%. Its prevalence in the population is affected by genetic, environmental, viral, infectious, immunological, biochemical, endocrinological, and psychological factors, as well as alcohol and drug abuse. In the recent years, psoriasis has been recognised as a systemic disease associated with numerous multiorgan abnormalities and complications. Dyslipidemia is one of comorbidities in psoriatic patients. Lipid metabolism studies in psoriasis have been started at the beginning of the 20th century and are concentrated on skin surface lipids, stratum corneum lipids and epidermal phospholipids, serum lipids, dermal low-density lipoproteins in the psoriatic skin, lipid metabolism, oxidative stress and correlations between inflammatory parameters, lipid parameters and clinical symptoms of the disease. On the basis of the literature data, psoriasis can be described as an immunometabolic disease.

APA, Harvard, Vancouver, ISO, and other styles

41

Popa, Iuliana. "The concept of sphingolipid rheostat in skin: a driving force for new active ingredients in cosmetic applications." OCL 25, no. 5 (August 22, 2018): D507. http://dx.doi.org/10.1051/ocl/2018043.

Full text

Abstract:

Skin is a representative model of the complex metabolism that lipids may trigger. It is known that the biosynthesis of these lipids in mammalian cells generally ensures the cell membranes stability and participates to the signaling function. In the inner layers of the skin, the “de-novo” synthesis is the driving force ensuring proliferation, development and intercellular signaling. To promote stratum corneum formation, lipid catabolism leads to the renewal of ceramides, fatty acids and cholesterol that are responsible for the cohesion of the stratum corneum, its permeability, hydration, moisturization and signalling with the outer skin layers, appendages and inner layers secretion (cytokines, neuropeptides). Some actives applied in local treatments (i.e., peptides, n-3 polyunsaturated fatty acids (PUFA), ceramides, urea or an aqueous extract of Gromwell) and in oral treatment (i.e., sphingomyelin, n-3 polyunsaturated fatty acids (PUFA)) promote sphingosine 1-phosphate (S1P) production by the sphingolipid rheostat via triggering the salvage process along with autophagy and detoxification in aged skin. This review gives some basis for using the concept of sphingolipid metabolism rheostat in skin as the driving force for the development of new cosmetic actives ingredients or for repositioning the benefits of other actives for the skin.

APA, Harvard, Vancouver, ISO, and other styles

42

Choe, ChunSik, Jürgen Lademann, and Maxim E. Darvin. "A depth-dependent profile of the lipid conformation and lateral packing order of the stratum corneum in vivo measured using Raman microscopy." Analyst 141, no. 6 (2016): 1981–87. http://dx.doi.org/10.1039/c5an02373d.

Full text

APA, Harvard, Vancouver, ISO, and other styles

43

Kahraman, Emine, Melis Kaykın, Hümeyra Şahin Bektay, and Sevgi Güngör. "Recent Advances on Topical Application of Ceramides to Restore Barrier Function of Skin." Cosmetics 6, no. 3 (August 20, 2019): 52. http://dx.doi.org/10.3390/cosmetics6030052.

Full text

Abstract:

Human skin is the largest organ of the body and is an effective physical barrier keeping it from environmental conditions. This barrier function of the skin is based on stratum corneum, located in the uppermost skin. Stratum corneum has corneocytes surrounded by multilamellar lipid membranes which are composed of cholesterol, free fatty acids and ceramides (CERs). Alterations in ceramide content of the stratum corneum are associated with numerous skin disorders. In recent years, CERs have been incorporated into conventional and novel carrier systems with the purpose of exogenously applying CERs to help the barrier function of the skin. This review provides an overview of the structure, function and importance of CERs to restore the barrier function of the skin following their topical application.

APA, Harvard, Vancouver, ISO, and other styles

44

Suhonen, Marjukka, S. Kevin Li, William I. Higuchi, and James N. Herron. "A Liposome Permeability Model for Stratum Corneum Lipid Bilayers Based on Commercial Lipids." Journal of Pharmaceutical Sciences 97, no. 10 (October 2008): 4278–93. http://dx.doi.org/10.1002/jps.21306.

Full text

APA, Harvard, Vancouver, ISO, and other styles

45

Thakur, Neha, Prabhat Jain, and Vivek Jain. "FORMULATION DEVELOPMENT AND EVALUATION OF TRANSFEROSOMAL GEL." Journal of Drug Delivery and Therapeutics 8, no. 5 (September 15, 2018): 168–77. http://dx.doi.org/10.22270/jddt.v8i5.1826.

Full text

Abstract:

Transfersomes are particularly optimized, ultradeformable (ultraflexible) lipid supramolecular aggregates, which are able to penetrate the mammalian skin intact. Transfersome is a type of carrier system which is capable of transdermal delivery of low as well as high molecular weight drugs. Transfersomes penetrate through the pores of stratum corneum which are smaller than its size and get into the underlying viable skin in intact form. Acne vulgaris is a disease of the pilosebaceous follicle characterized by non-inflammatory (open and closed comedones) and inflammatory lesions (papules, pustules, and nodules). In such situation transdermal drug delivery remains the most preferential mode of administration. But, stratum corneum forms the most formidable barrier for the penetration of drug through skin. To overcome the stratum corneum barrier, the use of lipid vesicles like transfersomes in delivery systems has involved increasing attention in recent years. The aim of the present study was to statistically optimize the vesicular formulations (Transfersomes) for enhanced skin delivery of a model drug Clindamycin Phosphate. Keywords: Transfersomes, Acne vulgaris, Clindamycin Phosphate

APA, Harvard, Vancouver, ISO, and other styles

46

Pullmannová, Petra, Elena Ermakova, Andrej Kováčik, Lukáš Opálka, Jaroslav Maixner, Jarmila Zbytovská, Norbert Kučerka, and Kateřina Vávrová. "Long and very long lamellar phases in model stratum corneum lipid membranes." Journal of Lipid Research 60, no. 5 (March 18, 2019): 963–71. http://dx.doi.org/10.1194/jlr.m090977.

Full text

Abstract:

Membrane models of the stratum corneum (SC) lipid barrier, either healthy or affected by recessive X-linked ichthyosis, constructed from ceramide [Cer; nonhydroxyacyl sphingosine N-tetracosanoyl-d-erythro-sphingosine (CerNS24) alone or with omega-O-acylceramide N-(32-linoleyloxy)dotriacontanoyl-d-erythro-sphingosine (CerEOS)], FFAs(C16–24), cholesterol (Chol), and sodium cholesteryl sulfate (CholS) were investigated. X-ray diffraction (XRD) revealed a previously unreported polymorphism of the membranes. In the absence of CerEOS, the membranes formed a short lamellar phase (SLP; the repeat distance d = 5.3 nm), a medium lamellar phase (MLP; d = 10.6 nm), or very long lamellar phases (VLLP; d = 15.9 and 21.2 nm). An increased CholS-to-Chol ratio modulated the membrane polymorphism, although the CholS phase separated at ≥ 7 weight% (of total lipids). The presence of CerEOS led to the stable long lamellar phase (LLP) with d = 12.2 nm and prevented VLLP formation. Our XRD results agree well with recently published cryo-electron microscopy data for vitreous skin sections, while also revealing new structures. Thus, lamellar phases with long repeat distances (MLP and VLLP) may be formed in the absence of omega-O-acylceramide, whereas these ultralong Cer species likely stabilize the final SC lipid architecture of LLP by riveting the adjacent lipid layers.

APA, Harvard, Vancouver, ISO, and other styles

47

Schmitt, Thomas, and Reinhard H. H. Neubert. "State of the Art in Stratum Corneum Research. Part II: Hypothetical Stratum Corneum Lipid Matrix Models." Skin Pharmacology and Physiology 33, no. 4 (2020): 213–30. http://dx.doi.org/10.1159/000509019.

Full text

APA, Harvard, Vancouver, ISO, and other styles

48

Bakar, Joudi, Rime Michael-Jubeli, Sana Tfaili, Ali Assi, Arlette Baillet-Guffroy, and Ali Tfayli. "Biomolecular modifications during keratinocyte differentiation: Raman spectroscopy and chromatographic techniques." Analyst 146, no. 9 (2021): 2965–73. http://dx.doi.org/10.1039/d1an00231g.

Full text

APA, Harvard, Vancouver, ISO, and other styles

49

Machado, Neila, Clarissa Callegaro, Marcelo Augusto Christoffolete, and Herculano Martinho. "Tuning the transdermal transport by application of external continuous electric field: a coarse-grained molecular dynamics study." Physical Chemistry Chemical Physics 23, no. 14 (2021): 8273–81. http://dx.doi.org/10.1039/d1cp00354b.

Full text

APA, Harvard, Vancouver, ISO, and other styles

50

Yarovoy, Yury, Dane M. Drutis, Thomas M. Hancewicz, Ursula Garczarek, K. P. Ananthapadmanabhan, and Manoj Misra. "Quantification of Lipid Phase Order of In Vivo Human Skin Using Attenuated Total Reflection Fourier Transform Infrared (ATR FT-IR) Spectroscopy and Multivariate Curve Resolution Analysis." Applied Spectroscopy 73, no. 2 (November 16, 2018): 182–94. http://dx.doi.org/10.1177/0003702818812738.

Full text

Abstract:

A new analysis methodology utilizing multivariate curve resolution (MCR) has been successfully combined with Fourier transform infrared (FT-IR) measurement of in vivo human skin to resolve lipid phase constituents in the spectra relative to high and low chain ordering. A clinical study was performed to measure lipid order through different depths of stratum corneum of human subjects. Fourier transform IR spectra were collected through the top 10 layers of the skin on four sites on the left and right forearm of 12 individuals. Depth profiling was achieved by tape stripping to remove layers of skin with 10 successive tapes from each site. In vivo ATR FT-IR spectra were collected after removing each tape. Three isolated spectral regions were analyzed, centered around 2850 cm−1, 1460–1480 cm−1, and 730 cm−1, corresponding to stretching, scissoring, and rocking –CH2 vibrational modes, respectively. Both traditional lipid conformation analysis and MCR analysis were performed on the same spectral data. The lipid order ratio, expressed as the fraction of highly ordered orthorhombic (OR) lipids to the total lipids content (orthorhombic + hexagonal [HEX] + liquid crystal [LC]), was assessed as function of depth. Lipid order depth profiles (LODP) show an increase in order with the stratum corneum depth which can be adequately described by an exponential function for the data obtained in this study. The LODP derived from the three vibrational modes show very similar trends, although the absolute order ratios are somewhat different. The variance of the skin LODP across individuals is much greater than between sites within the same individual. The higher arm sites closer to the elbow on the left and right arm show no statistically significant difference and are recommended for use in comparative studies. The scissoring mode shows the highest sensitivity for determination of LODP value.

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!