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Journal articles on the topic 'Lipodystrophy management'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Njelekela, Marina, Rose Mpembeni, Alfa Muhihi, Nzovu Ulenga, Eric Aris, and Deodatus Kakoko. "Lipodystrophy among HIV-Infected Patients Attending Care and Treatment Clinics in Dar es Salaam." AIDS Research and Treatment 2017 (2017): 1–10. http://dx.doi.org/10.1155/2017/3896539.

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Background. HIV infection and long-term HAART use are associated with metabolic and morphological changes. We assessed prevalence, types, and risk factors associated with lipodystrophy among HIV-infected adults attending CTC in Dar es Salaam, Tanzania. Methods. Analysis included 466 HIV-infected patients. Study protocol involved administration of structured questionnaire to collect sociodemographic and clinical information. Diagnosis of lipodystrophy was based on physician clinical assessment. Results. Lipodystrophy was present in 95 (20.4%) of the study participants, with lipoatrophy being th

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2

Thappa, Devinder Mohan. "Gynoid lipodystrophy – clinical and management issues." Cosmoderma 2 (September 14, 2022): 82. http://dx.doi.org/10.25259/csdm_96_2022.

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3

Hultman, C. Scott, Lindsee E. McPhail, Jeffrey H. Donaldson, and David A. Wohl. "Surgical Management of HIV-Associated Lipodystrophy." Annals of Plastic Surgery 58, no. 3 (2007): 255–63. http://dx.doi.org/10.1097/01.sap.0000248128.33465.83.

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4

Pirmohamed, Munir. "Clinical management of HIV-associated lipodystrophy." Current Opinion in Lipidology 20, no. 4 (2009): 309–14. http://dx.doi.org/10.1097/mol.0b013e32832d3bb1.

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5

Gautama, Hendra Ikhwan, and Jongky Hendro Prajitno. "A rare lipodystrophy syndrome with familial partial lipodystrophy 2 (FPLD2)." Bali Medical Journal 12, no. 3 (2023): 2424–29. http://dx.doi.org/10.15562/bmj.v12i3.4518.

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Background: Lipodystrophy (LD) syndromes are a diverse group of ultra-rare diseases characterized by adipose tissue deficiency, resulting in potentially severe metabolic disturbances. Due to their scarcity, diagnosis and management are often challenging for clinicians. This study aimed to report a rare case of LD syndromes, as well their diagnosis and possible management. Case Presentation: A 27-year-old female presented to Dr. Soetomo General Academic Hospital, Surabaya, Indonesia with a chief complaint of abdominal (epigastric) pain, accompanied by diarrhea, nausea, and vomiting. The patient

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6

Garg, Abhimanyu. "Lipodystrophies: Genetic and Acquired Body Fat Disorders." Journal of Clinical Endocrinology & Metabolism 96, no. 11 (2011): 3313–25. http://dx.doi.org/10.1210/jc.2011-1159.

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Abstract Context: Lipodystrophies are heterogeneous, genetic or acquired disorders characterized by selective loss of body fat and predisposition to insulin resistance. The extent of fat loss determines the severity of associated metabolic complications such as diabetes mellitus, hypertriglyceridemia, and hepatic steatosis. Evidence Acquisition and Synthesis: Both original and review articles were found via PubMed search reporting on clinical features and management of various types of lipodystrophies and were integrated with the author's knowledge of the field. Conclusion: The autosomal reces

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7

Gold, Daniel R., and Donald J. Annino. "HIV-Associated Cervicodorsal Lipodystrophy: Etiology and Management." Laryngoscope 115, no. 5 (2005): 791–95. http://dx.doi.org/10.1097/01.mlg.0000161838.22766.88.

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8

Davison, Steven P., Joseph Timpone, and Catherine M. Hannan. "Surgical Algorithm for Management of HIV Lipodystrophy." Plastic and Reconstructive Surgery 120, no. 7 (2007): 1843–58. http://dx.doi.org/10.1097/01.prs.0000267341.14550.a7.

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9

Bodasing, N., and R. Fox. "HIV-associated Lipodystrophy Syndrome: Assessment and Management." Journal of Infection 46, no. 2 (2003): 87–93. http://dx.doi.org/10.1053/jinf.2002.1103.

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10

Foss-Freitas, Maria C., Baris Akinci, Yingying Luo, Andra Stratton, and Elif A. Oral. "Diagnostic strategies and clinical management of lipodystrophy." Expert Review of Endocrinology & Metabolism 15, no. 2 (2020): 95–114. http://dx.doi.org/10.1080/17446651.2020.1735360.

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11

Bezawada, Shravani, Anuradha H. V., and Pramila Kalra. "Prevalence of insulin induced lipodystrophy in patients with diabetes mellitus in a tertiary care centre: a cross sectional study." International Journal of Basic & Clinical Pharmacology 8, no. 4 (2019): 710. http://dx.doi.org/10.18203/2319-2003.ijbcp20191105.

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Background: Diabetes Mellitus is a spectrum of common metabolic disorders whose management mainly lies in treating the patients with oral hypoglycaemic drugs and insulin along with the dietary and lifestyle modifications. Lipodystrophy is the most neglected adverse drug effect caused by injecting insulin. The main objective of this study was to assess the prevalence of lipodystrophy at the insulin injection sites in patients suffering from diabetes mellitus (Type 1 and Type 2).Methods: A cross-sectional study was conducted in the Department of Endocrinology on 250 diabetic patients taking insu

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12

Rochford, Justin J. "When Adipose Tissue Lets You Down: Understanding the Functions of Genes Disrupted in Lipodystrophy." Diabetes 71, no. 4 (2022): 589–98. http://dx.doi.org/10.2337/dbi21-0006.

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Lipodystrophy syndromes are conditions in which the adipose tissue mass of an individual is altered inappropriately. The change in adipose mass can range from a relatively modest and subtle redistribution in some individuals with partial lipodystrophy to a near-complete absence of adipose tissue in the most severe forms of generalized lipodystrophy. The common feature is a disconnection between the need of the individual for a safe, healthy lipid storage capacity and the available adipose mass to perform this critical role. The inability to partition lipids for storage in appropriately functio

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13

Stears, Anna, and Catherine Hames. "Diagnosis and management of lipodystrophy: a practical update." Clinical Lipidology 9, no. 2 (2014): 235–59. http://dx.doi.org/10.2217/clp.14.13.

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14

Brown, William Virgil, Abhimanyu Garg, Phillip Gorden, and Robert Shamburek. "JCL roundtable: Diagnosis and clinical management of lipodystrophy." Journal of Clinical Lipidology 10, no. 4 (2016): 728–36. http://dx.doi.org/10.1016/j.jacl.2016.06.005.

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15

Rossouw, T. Marie, M. E. Botes, and F. Conradie. "Overview of HIV-related lipodystrophy." Southern African Journal of HIV Medicine 14, no. 1 (2013): 29–33. http://dx.doi.org/10.4102/sajhivmed.v14i1.100.

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Lipodystrophy is a well-recognised adverse effect of HIV and antiretroviral therapy, with certain antiretrovirals, specifically thymidine analogues, implicated in the aetiology and pathogenesis. Lipodystrophy is often accompanied by metabolic complications, such as hyperlipidaemia and insulin resistance, which increase risk for cardiovascular disease. There are limited data on the effect of treatment modification, pharmacological interventions and surgical management on this condition.  Here we summarise the latest data on lipodystrophy, with the aim of facilitating informed decision-mak

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16

Wierzbicki, Anthony S., Scott D. Purdon, Timothy C. Hardman, Ranjababu Kulasegaram, and Barry S. Peters. "Review: Clinical aspects of the management of HIV lipodystrophy." British Journal of Diabetes & Vascular Disease 8, no. 3 (2008): 113–19. http://dx.doi.org/10.1177/14746514080080030201.

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17

Bhujel, N., and H. Clark. "Case report: Dental management of Berardinelli-Seip congenital lipodystrophy." European Archives of Paediatric Dentistry 17, no. 2 (2015): 137–40. http://dx.doi.org/10.1007/s40368-015-0210-z.

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18

José, Anthar Ávalos Narváez, Daniel Lupercio Romo Cesar, Cuadra Casillas Alondra, et al. "Surgical Management of Lipodystrophy in Barraquer-Simons Syndrome: Autologous Fat Redistribution and Reconstructive Strategies for Acquired Partial Lipodystrophy." International Journal of Medical Science and Clinical Research Studies 5, no. 05 (2025): 794–99. https://doi.org/10.5281/zenodo.15550516.

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<strong>Background:</strong> Barraquer-Simons Syndrome (BSS), a rare form of acquired partial lipodystrophy, is characterized by progressive adipose tissue loss in the cephalothoracic region, often with paradoxical fat accumulation in the lower body. This condition presents significant metabolic and aesthetic challenges, necessitating multidisciplinary management. Fat redistribution surgery (FRS) has emerged as a potential therapeutic approach to restore facial and upper body contour while addressing metabolic complications. <strong>Objective:</strong> This article reviews the surgical techniq

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19

Kungurtseva, A. L., and A. V. Vitebskaya. "Differential Diagnosis of Progeroid Neonatal Syndrome." Doctor.Ru 22, no. 7 (2023): 37–42. http://dx.doi.org/10.31550/1727-2378-2023-22-7-37-42.

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Aim. Аnalysis and synthesis of the literature data on the problem of differential diagnosis of neonatal progeroid syndrome. Key points. One of the rarest representatives of premature aging syndromes is neonatal progeroid syndrome (Wiedemann–Rautenstrauch syndrome). It is an ultra-orphan disease with autosomal recessive type of inheritance, associated with a mutation in the POLR3A, POLR3B, POLR3GL genes and characterized by congenital lipodystrophy and premature aging. The disease manifests from the first days of life: low body length and weight at birth, pronounced phenotypic features (pseudoh

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20

Nicholas, Patrice K., Kenn M. Kirksey, Inge B. Corless, and Jeanne Kemppainen. "Lipodystrophy and quality of life in HIV: symptom management issues." Applied Nursing Research 18, no. 1 (2005): 55–58. http://dx.doi.org/10.1016/j.apnr.2004.09.012.

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21

Nestorowicz, Ann, and Stephen Cameron. "Key reports from the 9th International Workshop on Adverse Drug Reactions and Lipodystrophy in HIV 2007." Antiviral Therapy 12, no. 6 (2007): 987–98. http://dx.doi.org/10.1177/135965350701200617.

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The 9th International Workshop on Adverse Drug Reactions and Lipodystrophy in HIV provided a forum for the presentation of basic and clinical research focused on the pathogenesis and management of lipodystrophy and other adverse events associated with antiretroviral therapy. New data were reported on the contribution of both antiretroviral therapy and HIV infection itself on the development of metabolic abnormalities in patients with lipodystrophy, including insulin resistance and dyslipidaemia, which are associated with an increased risk of diabetes and cardiovascular disease. In addition, an

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22

Tarr, Philip E., and Amalio Telenti. "Toxicogenetics of Antiretroviral Therapy: Genetic Factors that Contribute to Metabolic Complications." Antiviral Therapy 12, no. 7 (2007): 999–1014. http://dx.doi.org/10.1177/135965350701200714.

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Metabolic complications of antiretroviral therapy (ART) have emerged as a major concern for long-term, successful management of HIV infection. Variability in the response to ART between individuals has been increasingly linked to the genetic background of patients, as regards efficacy and susceptibility to adverse reactions (toxicogenetics). This review summarizes the biological and methodological background for the genetic prediction of metabolic toxicity of ART. Recent studies are discussed which suggest that single-nucleotide polymorphisms (SNPs) in several genes involved in lipid metabolis

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23

Viglino, Francesca, Maha Sellami, Fabio Broglio, et al. "The Role of the Person Focused IARA Model in Reducing Anxiety and Improving Body Awareness and Illness Management in Diabetics with Acquired Lipodystrophy: A Mixed-Method Study." Journal of Personalized Medicine 12, no. 11 (2022): 1865. http://dx.doi.org/10.3390/jpm12111865.

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Background: Lipodystrophy is one of the most frequent complications in people with diabetes following subcutaneous insulin therapy, and poor management can lead to several problems, such as impaired glycemic control and adherence to therapy, anxiety, and depression. Poor injection technique represents the main risk factor for lipodystrophies. In order to enhance the patient’s insulin injection technique to heal lipodystrophy, improve psychological indices, and promote involvement in their health and care, the efficacy of emerging person-centered care called the IARA model was tested. Methods:

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24

Gautam, Anjali, Purnachandra Badabagni, Surender Singh, Archana Mavoori, Pranavi Katike, and Sravya Himasri Bhamidipati. "Barraquer–Simons syndrome: A rare case of acquired partial lipodystrophy after pregnancy with diabetes mellitus." Cosmoderma 4 (November 7, 2024): 136. http://dx.doi.org/10.25259/csdm_150_2024.

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Barraquer–Simons syndrome (BSS) is an uncommon acquired partial lipodystrophy (APL) characterized by gradual, progressive loss of subcutaneous fat limited to the upper part of the body. It is a rare condition of uncertain origin typically appearing in early adolescence with a higher incidence among females with autoimmunity and C3 hypocomplementemia. Approximately 250 cases were reported worldwide, we present a case of BSS that began after pregnancy. A biopsy of the affected areas reveals reduced adipocytes. Metabolic abnormalities are relatively uncommon in APL compared to other forms of lipo

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25

Majumdar, Sujoyeeta, Ruchi Gaba, Nalini Ram, and Bahar Kapoor Force. "LBODP030 A Rare Case Of Partial Lipodystrophy From Mpdl (mandibular Hypoplasia, Deafness, Progeroid, Lipodystrophy Syndrome) Due To Pold1 Gene Mutation." Journal of the Endocrine Society 6, Supplement_1 (2022): A236—A237. http://dx.doi.org/10.1210/jendso/bvac150.485.

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Abstract MDPL (Mandibular hypoplasia, Deafness, Progeroid, Lipodystrophy syndrome) caused by a mutation in the polymerase delta 1 (POLD1) gene is an extremely rare progeroid syndrome associated with partial lipodystrophy. Currently, there are about 24 cases reported worldwide(1), mostly in people of European descent. We are reporting one such rare case in a Hispanic patient. The patient is a 37 year old male from Honduras who was referred to us by genetics for diabetes management. Family members noted extremely thin limbs and he did not walk till 2 years of age. Family history was negative wit

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26

Loonam, Cathríona Rosemary, and Anne Mullen. "Nutrition and the HIV-associated lipodystrophy syndrome." Nutrition Research Reviews 25, no. 2 (2012): 267–87. http://dx.doi.org/10.1017/s0954422411000138.

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HIV-associated lipodystrophy syndrome (HALS), comprising metabolic and morphological alterations, is a known side effect of highly active antiretroviral therapy (HAART). Evidence for the role of nutrition in the management of the systemic parameters of HALS is currently limited. In the present paper we review the current knowledge base surrounding HALS, focusing particularly on the role of nutrition in mitigating the systemic parameters of the syndrome. Reported prevalence of HALS was found to vary from 9 to 83 % due to lack of a standardised definition, as well as variations in assessment met

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27

Brown, Rebecca J., David Araujo-Vilar, Pik To Cheung, et al. "The Diagnosis and Management of Lipodystrophy Syndromes: A Multi-Society Practice Guideline." Journal of Clinical Endocrinology & Metabolism 101, no. 12 (2016): 4500–4511. http://dx.doi.org/10.1210/jc.2016-2466.

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28

Hirsch, H. H., and M. Battegay. "Lipodystrophy Syndrome by HAART in HIV-Infected Patients: Manifestation, Mechanisms and Management." Infection 30, no. 5 (2002): 293–98. http://dx.doi.org/10.1007/s15010-002-3044-7.

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29

Finkelstein, Julia L., Pooja Gala, Rosemary Rochford, Marshall J. Glesby, and Saurabh Mehta. "HIV/AIDS and lipodystrophy: Implications for clinical management in resource-limited settings." Journal of the International AIDS Society 18, no. 1 (2015): 19033. http://dx.doi.org/10.7448/ias.18.1.19033.

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30

Innes, Steve, Leon Levin, and Mark Cotton. "Lipodystrophy syndrome in HIV-infected children on HAART." Southern African Journal of HIV Medicine 10, no. 4 (2009): 76. http://dx.doi.org/10.4102/sajhivmed.v10i4.264.

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Lipodystrophy Syndrome (LD) is common in HIV-infected children, particularly in those taking Didanosine, Stavudine, or Zidovudine. Lipoatrophy in particular causes major stigmatization and interferes with adherence. In addition, LD may have significant long-term health consequences, particularly cardiovascular. Since the stigmatizing fat distribution changes of LD are largely permanent, the focus of management remains on early detection and arresting progression. Practical guidelines for surveillance and avoidance of LD in routine clinical practice are presented. Diagnosis of LD is described a

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31

Abdela, Abdurezak Ahmed, Helen Yifter, Ahmed Reja, Aster Shewaamare, Ighovwerha Ofotokun, and Wondwossen Amogne Degu. "Prevalence and risk factors of metabolic syndrome in Ethiopia: describing an emerging outbreak in HIV clinics of the sub-Saharan Africa – a cross-sectional study." BMJ Open 13, no. 12 (2023): e069637. http://dx.doi.org/10.1136/bmjopen-2022-069637.

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ObjectivesHIV-induced chronic inflammation, immune activation and combination antiretroviral therapy (cART) are linked with adverse metabolic changes known to cause cardiovascular adversities. This study evaluates the prevalence of lipodystrophy, and metabolic syndrome (MetS), and analyses risk factors in HIV-infected Ethiopians taking cART.MethodsA multicentre cross-sectional study was conducted at tertiary-level hospitals. Eligible participants attending the HIV clinics were enrolled. Sociodemographic, anthropometric, clinical, HIV treatment variables, lipid profile, fasting blood glucose le

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32

Jéru, Isabelle, Marie-Christine Vantyghem, Elise Bismuth, et al. "Diagnostic Challenge in PLIN1-Associated Familial Partial Lipodystrophy." Journal of Clinical Endocrinology & Metabolism 104, no. 12 (2019): 6025–32. http://dx.doi.org/10.1210/jc.2019-00849.

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Abstract Context Heterozygous frameshift variants in PLIN1 encoding perilipin-1, a key protein for lipid droplet formation and triglyceride metabolism, have been implicated in familial partial lipodystrophy type 4 (FPLD4), a rare entity with only six families reported worldwide. The pathogenicity of other PLIN1 null variants identified in patients with diabetes and/or hyperinsulinemia was recently questioned because of the absence of lipodystrophy in these individuals and the elevated frequency of PLIN1 null variants in the general population. Objectives To reevaluate the pathogenicity of PLIN

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33

Guaraldi, Giovanni, and Stefano Zona. "From lipodystrophy to cardiovascular disease: new insight into the management of HIV infection." Clinical Lipidology 5, no. 4 (2010): 583–93. http://dx.doi.org/10.2217/clp.10.32.

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34

Karhan, Asuman Nur, Jamila Zammouri, Martine Auclair, et al. "Biallelic CAV1 null variants induce congenital generalized lipodystrophy with achalasia." European Journal of Endocrinology 185, no. 6 (2021): 841–54. http://dx.doi.org/10.1530/eje-21-0915.

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Objective CAV1 encodes caveolin-1, a major protein of plasma membrane microdomains called caveolae, involved in several signaling pathways. Caveolin-1 is also located at the adipocyte lipid droplet. Heterozygous pathogenic variants of CAV1 induce rare heterogeneous disorders including pulmonary arterial hypertension and neonatal progeroid syndrome. Only one patient was previously reported with a CAV1 homozygous pathogenic variant, associated with congenital generalized lipodystrophy (CGL3). We aimed to further delineate genetic transmission, clinical, metabolic, and cellular characteristics of

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35

Telang, Parag S. "Lipodystrophy of Abdominal Pannus: A Severe Complication of Phosphatidyl Choline Injections." Indian Journal of Plastic Surgery 54, no. 02 (2021): 215–17. http://dx.doi.org/10.1055/s-0041-1731261.

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Abstract“Injection lipolysis” or “mesotherapy” is done for introducing various substances into deeper layers of the skin with the aim to dissolve subcutaneous fat. However, the safety profile of these chemicals is poorly regulated. Therefore, they may cause side effects or long-term sequelae that can be disastrous for the patient. We present such a case that required surgical management to salvage it and to give an aesthetically acceptable result.

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36

Jeon, Faith Hyun Kyung, Michelle Griffin, Carole Frosdick, and Peter Edward Michael Butler. "Lipotransfer provides effective soft tissue replacement for acquired partial lipodystrophy." BMJ Case Reports 13, no. 5 (2020): e232601. http://dx.doi.org/10.1136/bcr-2019-232601.

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We present a 48-year-old female patient who presented with features consistent with acquired partial lipodystrophy (APL) also known as ‘Barraquer-Simons syndrome’. It is a rare disease characterised by a gradual and progressive onset of lipoatrophy limited to the face, neck, upper limbs, thorax and abdomen and sparing the lower extremities. The resultant physical appearance can have significant psychosocial sequelae, further compounded by misdiagnosis and delay in recognition and management. Treatment is aimed at surgical correction of soft tissue destruction. Autologous fat transfer is an est

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37

Lee, Qin Zhi, Hwee Ching Tee, and Jin Hui Ho. "NOT JUST TYPE 2 DIABETES." Journal of the ASEAN Federation of Endocrine Societies 40, S1 (2025): 85–86. https://doi.org/10.15605/jafes.040.s1.145.

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INTRODUCTION/BACKGROUNDLipodystrophy syndromes are rare disorders of adipose tissue distribution, often leading to severe insulin resistance and metabolic complications. We present a case of a young woman initially diagnosed with type 2 diabetes, unresponsive to standard insulin therapy, who was ultimately diagnosed with familial partial lipodystrophy (FPLD). CASEA 26-year-old female, with diabetes diagnosed 4 years ago, was referred for uncontrolled capillary blood glucose levels persistently ranging from 20–25 mmol/L despite high-dose basal-bolus insulin and oral hypoglycemic agents. Her bod

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38

Gupta, Nidhi, Noor Asi, Wigdan Farah, et al. "Clinical Features and Management of Non-HIV–Related Lipodystrophy in Children: A Systematic Review." Journal of Clinical Endocrinology & Metabolism 102, no. 2 (2016): 363–74. http://dx.doi.org/10.1210/jc.2016-2271.

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39

Zhang, Yi, Xiaofei Chen, Feixiang Luo, Lihua Jiang, Jialu Xu, and Shuohui Chen. "Medical management of a child with congenital generalized lipodystrophy accompanied with progressive myoclonic epilepsy." Medicine 98, no. 48 (2019): e18121. http://dx.doi.org/10.1097/md.0000000000018121.

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40

Gupta, Nidhi, Noor Asi, Wigdan Farah, et al. "Abstract #212: Clinical Manifestations and Management of Non-HIV Related Lipodystrophy: A Systematic Review." Endocrine Practice 22 (May 2016): 35–36. http://dx.doi.org/10.1016/s1530-891x(20)44920-1.

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41

Calderoni, Davi Reis, Tamara Margatho Ramos, Jeser Rodrigues de Castro, and Paulo Kharmandayan. "Surgical management of phenotypic alterations related to the Dunnigan variety of familial partial Lipodystrophy." Journal of Plastic, Reconstructive & Aesthetic Surgery 64, no. 9 (2011): 1248–50. http://dx.doi.org/10.1016/j.bjps.2011.02.009.

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42

Cimino, Antonino, Umberto Valentini, Armando Rotondi, Enrico Radaeli, and Gianni Giustina. "Continuous subcutaneous insulin infusion (CSII) in the management of diabetic lipodystrophy: a case report." Acta Diabetologica Latina 24, no. 2 (1987): 165–67. http://dx.doi.org/10.1007/bf02742855.

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43

IJDDA, Sara, Meriem Ben Lafqih, Sana Rafi, Ghizlane El Mghari, and Nawal El Ansari. "The life of a Patient without Adipose Tissue: From Adipocyte Dysfunction to Metabolic Complications." Scholars Journal of Medical Case Reports 10, no. 4 (2022): 329–33. http://dx.doi.org/10.36347/sjmcr.2022.v10i04.016.

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Life without adipose tissue: Congenital generalized lipodystrophy; Origin, pathophysiology and therapeutic management Congenital Generalized Lipodystrophies also known as Berardinelli-Seip Congenital Lipodystrophy (BSCL) represent the most extreme phenotype of lipodystrophies. BSCLs are characterized by an almost total loss of adipose tissue and a predisposition to develop metabolic complications such as diabetes, hypertriglyceridemia ( hyperTG) and non-alcoholic fatty liver disease (NAFLD). Four subtypes of BSCL are distinguished according to the gene involved: AGPAT2 encoding the enzyme 1-ac

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44

SALEEM, S., A. NAUSHEEN, S. BAKSHI, H. SADDIQUE, SS TESNEEM, and R. JABEEN. "ASSIGNMENT OF KNOWLEDGE, COMPLICATIONS, AND SELF ADMINISTRATION OF INSULIN AMONG DIABETIC PATIENTS." Biological and Clinical Sciences Research Journal 2024, no. 1 (2024): 1293. http://dx.doi.org/10.54112/bcsrj.v2024i1.1293.

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Insulin self-administration is a cornerstone of diabetes management, yet many patients face challenges due to knowledge deficits and improper practices. Objective: This study assesses the knowledge, practices, and barriers related to insulin self-administration among diabetic patients attending a tertiary care clinic in Pakistan. Methods: A descriptive cross-sectional study was conducted at Johar Poly Clinic, Lahore, with 130 diabetic patients recruited using convenience sampling. Data were collected through a structured questionnaire assessing demographics, knowledge, practices, and complicat

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Melvin, Audrey, Claire Adams, Catherine Flanagan, et al. "Roux-en-Y Gastric Bypass Surgery in the Management of Familial Partial Lipodystrophy Type 1." Journal of Clinical Endocrinology & Metabolism 102, no. 10 (2017): 3616–20. http://dx.doi.org/10.1210/jc.2017-01235.

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46

Tadayyon, Moh, and Stephen Cameron. "Key Data from the 10th International Workshop on Adverse Drug Reactions and Lipodystrophy in HIV, 6–8 November 2008, London, UK." Antiviral Therapy 13, no. 8 (2008): 1115–27. http://dx.doi.org/10.1177/135965350801300809.

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Although the list of clinical complications associated with HIV therapy continues to grow, the underlying mechanisms remain incompletely understood. Metabolic abnormalities, such as dyslipidaemia, insulin resistance and cardiovascular disease continue to top the list, but there is an increasing appreciation of the effect of HIV and anti-retroviral therapy on body composition, bone metabolism, muscle function and autonomic nervous system control of lipid and glucose metabolism. The 10th International Workshop on Adverse Drug Reactions and Lipodystrophy in HIV brought together physicians and res

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Tipu, Ali, Farhad Hasan, and Michael Grimes. "Familial Partial Lipodystrophy: A Case Study and Review of Recent Literature." Journal of the Endocrine Society 5, Supplement_1 (2021): A308—A309. http://dx.doi.org/10.1210/jendso/bvab048.629.

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Abstract Introduction: Familial partial lipodystrophy (FPLD) is a rare genetic disorder characterized by loss of subcutaneous adipose tissue, mainly from the extremities and gluteal region. FPLD is associated with a variety of metabolic abnormalities including severe hypertriglyceridemia (HTG), insulin resistance (IR), and hepatic steatosis. We present a case of FPLD and summarize recent literature on the metabolic features and their management in patients with this rare disease. Case: A 44 year old female with medical history of Type 2 DM, hypertension, hypothyroidism and recurrent pancreatit

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Rudorf, Dorothea C., and Susan A. Krikorian. "Adverse Effects Associated With Antiretroviral Therapy and Potential Management Strategies." Journal of Pharmacy Practice 18, no. 4 (2005): 258–77. http://dx.doi.org/10.1177/0897190005278510.

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A variety of adverse drug reactions (ADRs) affecting many organ systems may be observed with antiretroviral therapy (ARV), and they can be differentiated into short- and long- term effects, class effects, or individual drug effects. Commonly seen ADRs include dermatological reactions, associated with nonnucleoside reverse transcriptase inhibitors (NNRTIs) and some protease inhibitors (PIs), and gastrointestinal problems, a major side effect of PIs and of some nucleoside reverse transcriptase inhibitors (NRTIs). Metabolic complications are frequently reported in HIV-infected patients on ARV and

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Wulandari, Desy, Azwin Mengindra Putera Lubis, Zahrah Hikmah, and Anang Endaryanto. "Successful management of a 7-year-old-female with juvenile dermatomyositis at a tertiary hospital in low-income country." Paediatrica Indonesiana 64, no. 6 (2024): 551–8. https://doi.org/10.14238/pi64.6.2024.551-8.

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Juvenile dermatomyositis (JDM) is a rare chronic autoimmune disease belonging to idiopathic inflammatory myopathies. Pathological skin lesions and proximal weakness primarily characterize this entity, but clinical symptoms can be heterogeneous. Children are more likely to have long-term complications such as lipodystrophy, calcinosis, and vasculopathy. Calcinosis is one of the characteristic sequelae of JDM, despite recent advances in the treatment of JDM, about one-third of patients still develop dystrophic calcinosis. In low-income countries, the availability of medicines is very limited. In

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Rosińska, Kamila, Ewelina Justyna Janicka, Julia Natalia Skibicka, Monika Niedźwiedzka, and Mateusz Rosiński. "Disorders of Adipose Tissue and Lipodystrophies: Causes, Consequences, and Treatment Perspectives." Quality in Sport 38 (February 11, 2025): 58194. https://doi.org/10.12775/qs.2025.38.58194.

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Lipodystrophies are rare metabolic disorders characterized by the loss of adipose tissue, which can manifest as generalized, partial, or localized. This condition is associated with metabolic complications such as insulin resistance, diabetes, hypertriglyceridemia, and liver steatosis. The paper discusses the classification of lipodystrophies by etiology and fat loss extent, including generalized and partial forms, both congenital and acquired. Special focus is placed on HIV-associated lipodystrophy due to the prevalence of antiretroviral therapy. The pathophysiology involves disrupted adipoge

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