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Dissertations / Theses on the topic 'Liposomes'

Author: Grafiati
Published: 4 June 2021
Last updated: 9 June 2025

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1

Heeremans, Anneke. "Liposomes in thrombolytic therapy : t-PA targeting with plasminogen-liposomes, a novel concept = Liposomen voor thrombolytische therapie /." [S.l. : s.n.], 1995. http://www.gbv.de/dms/bs/toc/186694245.pdf.

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2

Thibault, Benoit. "Les liposomes : méthodes de préparation." Paris 5, 1990. http://www.theses.fr/1990PA05P177.

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3

Loughrey, Helen. "Targeted liposomes." Thesis, University of British Columbia, 1989. http://hdl.handle.net/2429/29180.

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This thesis presents an optimized and general procedure for coupling proteins to liposomes and investigates certain aspects of the interaction of liposomes with components of the circulation. The object of these studies was to develop straightforward methods for the preparation of well characterized protein-liposome conjugates which exhibit extended circulation half-lives in the blood. These favorable properties should potentiate the use of protein coupled vesicles in in vivo applications such as targeting or diagnostic protocols. A general approach for the preparation of protein-liposome conj
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4

Mougin-Degraef, Marie Faivre-Chauvet Alain. "Les liposomes." [S.l.] : [s.n.], 2004. http://theses.univ-nantes.fr/thesemed/PHmougin.pdf.

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5

Gyanani, Vijay. "Turning stealth liposomes into cationic liposomes for anticancer drug delivery." Scholarly Commons, 2013. https://scholarlycommons.pacific.edu/uop_etds/147.

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Targeting the anticancer agents selectively to cancer cells is desirable to improve the efficacy and to reduce the side effects of anticancer therapy. Previously reported passive tumor targeting by PEGylated liposomes (stealth liposomes) have resulted in their higher tumor accumulation. However their interaction with cancer cells has been minimal due to the steric hindrance of the PEG coating. This dissertation reports two approaches to enhance the interaction of stealth liposomes with cancer cells. First, we designed a lipid-hydrazone-PEG conjugate that removes the PEG coating at acidic pH as
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6

Chen, Xiaoyu. "Investigation of liposomes and liposomal gel for prolonging the therapeutic effects of pharmaceutical ingredients." HKBU Institutional Repository, 2013. http://repository.hkbu.edu.hk/etd_ra/1524.

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7

Rodríguez, Fernández Silvia. "Phosphatidylserine-rich liposomes to tackle autoimmunity. En route to translationality." Doctoral thesis, Universitat Autònoma de Barcelona, 2019. http://hdl.handle.net/10803/667944.

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Les malalties autoimmunitàries estan causades per defectes en la tolerància immunològica, i afecten a gairebé un 10% de la població. Darrerament, diverses intervencions mèdiques han convertit aquestes malalties en cròniques, però el seu diagnòstic encara comporta morbiditat i mortalitat elevades. Així, un repte biomèdic urgent és el desenvolupament de teràpies que puguin restablir selectivament la tolerància, aturin l’atac autoimmunitari i permetin la regeneració del teixit danyat. En condicions fisiològiques, la fagocitosi de cèl·lules apoptòtiques per part de fagòcits com les cèl·lules dendr
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8

Bohl, Kullberg Erika. "Tumor Cell Targeting of Stabilized Liposome Conjugates : Experimental studies using boronated DNA-binding agents." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3435.

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9

White, Karen Louise, and n/a. "Modified liposomes as adjuvants." University of Otago. School of Pharmacy, 2005. http://adt.otago.ac.nz./public/adt-NZDU20070126.131417.

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Despite the progress in elucidating antigens for both therapeutic and prophylactic vaccines, safety concerns over current vaccine delivery vehicles and adjuvants has limited the development of new vaccines. In particular, there is an urgent need for effective vaccines capable of stimulating cytotoxic T lymphocyte (CTL) responses against intracellular pathogens or tumor cells. Liposomes are under investigation as a particulate vaccine delivery system with the required safety profile and demonstrated ability to target antigens to dendritic cells (DC), the cells of the immune system responsible f
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10

Frost, S. J. "Analytical applications of liposomes." Thesis, University of Surrey, 1994. http://epubs.surrey.ac.uk/2745/.

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Liposomes have established roles in drug delivery and cell membrane studies. Amongst other applications; they can also be used as analytical reagents, particularly in immunoassays. Liposomal immunoassays have potential advantages over alternatives; including sensitivity, speed, simplicity and relative reagent stability. The aim of these studies was to develop and evaluate novel examples of these assays. When liposomes entrapped the dye, Sulphorhodamine B, a shift in its maximum absorption wavelength compared to free dye was observed. This was attributed to dimerization of the dye at high conce
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11

Bennett, Doyle Edward. "Photoinduced fusion of liposomes." Diss., The University of Arizona, 1995. http://hdl.handle.net/10150/187055.

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The photopolymerization of two-component large unilamellar liposomes (LUV) composed of 3/1 dioleoylphosphatidylethanolamine (DOPE) and either 1,2-bis- (10-(2',4'-hexadienoyloxy)decanoyl) -sn-glycero-3-phosphatidylcholine (bis-SorbPC) or 1-palmitoyl-2- (10-(2$\sp\prime,4\sp\prime$-hexadienoyloxy) decanoyl) -sn-glycero-3-phosphocholine (mono-SorbPC) facilitated liposome fusion. Fusion was characterized by fluorescent assays for lipid mixing, aqueous contents mixing, and aqueous contents leakage. The rate and extent of the photoinduced fusion was dependent on the extent of polymerization, tempera
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12

Pejaver, Satish K. "Kinetics in liposomal systems : drug stabilization ; synthesis and degradation of liposome prodrugs /." The Ohio State University, 1986. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487323583620435.

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13

Celli, Irène. "Liposomes et perspectives thérapeutiques : application à la dermopharmacie." Paris 5, 1992. http://www.theses.fr/1992PA05P200.

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14

Freva, Patrick. "Apport des liposomes thermo-sensibles dans le ciblage des drogues antimitotiques : études "in vitro" et "in vivo"." Paris 5, 1989. http://www.theses.fr/1989PA05P144.

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15

Laníková, Petra. "Studium vlivu lipozomálních platinových cytostatik na nádorové buňky pomocí voltametrických metod." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2017. http://www.nusl.cz/ntk/nusl-316850.

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Aim of this thesis is voltammetric study influence of liposomal platinum cytostatics on cancer cells. One of the goals is summarize available informations about influence of cisplatine on cancer cells, its encapsulation into liposome and affection of this cytostatic cisplatin encapsulated in liposome on cancer cell lines. In literary recherche is detail description of these issues. Than is there specification of voltammetric methods, which serve to electrochemical detection of cisplatin. Based on literary recherche was chosen the best method for detection and subsequently the method was optima
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16

Kosmerl, Erica L. "Investigation of Bioactive Milk Phospholipid Liposomes and Soy Phospholipid Liposomes on Adipocyte Physiology." The Ohio State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu1565776533223238.

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17

Tomsen, Melero Judit. "Study of New Liposomes for the Delivery of Enzymes through Biological Membranes." Doctoral thesis, Universitat Autònoma de Barcelona, 2021. http://hdl.handle.net/10803/673786.

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Els liposomes són nanovesícules lipídiques àmpliament explorades per ser utilitzades com a transportadors d’actius terapèutics per al desenvolupament de noves nanomedicines. En la present Tesi s’ha estudiat l’ús d’aquests sistemes liposomals funcionalitzats amb lligands per ser utilitzats com a nanotransportadors d’enzims, específicament, pel transport eficaç de l’enzim α-galactosidasa a través de les membranes biològiques, com la membrana cel·lular o la barrera hematoencefàlica, per tal d’aconseguir un nou producte farmacèutic pel tractament de la malaltia de Fabry. La malaltia de Fabry és un
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18

Haan, Aalzen de. "Mucosal immunoadjuvant activity of liposomes." [S.l. : [Groningen] : s.n.] ; [University Library Groningen] [Host], 1995. http://irs.ub.rug.nl/ppn/142082376.

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19

Nagy, Ingrid. "The physical stability of liposomes /." Ann Arbor : University Microfilms International, 1987. http://www.gbv.de/dms/bs/toc/016141016.pdf.

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20

Chen, Jianmeizi. "Functionalised liposomes for tumour targeting." Thesis, Imperial College London, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.505002.

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21

Allen, Rosamund Elizabeth. "Liposomes as drug delivery systems." Thesis, University of Essex, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.352982.

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22

Joshi, Sameer. "Liposomes : a multifaceted delivery system." Thesis, Aston University, 2017. http://publications.aston.ac.uk/33302/.

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In the past two decades, liposomes have been employed extensively as vehicles to modify and enhance the delivery of drugs, vaccines, and biomolecules. This highly versatile drug delivery system lends itself to a plethora of applications, providing both safety and efficacy. Within this thesis, the potential of liposomes to deliver challenging drugs has been explored, including the co-delivery of drugs of divergent solubility and an anti-respiratory syncytial virus (RSV) peptide. Prior to the formulation development, the HPLC based method for simultaneous analysis of the drugs metformin HCl and
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23

Friede, M. H. "Receptor mediated targeting of liposomes." Doctoral thesis, University of Cape Town, 1990. http://hdl.handle.net/11427/22516.

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The targeting of liposomes to cells and the delivery of the liposomal contents into the cells have been investigated using either α-melanocyte stimulating hormone or Ricin-B-chain as ligands for promoting the binding of liposomes to cells. α-melanocyte stimulating hormone has been conjugated to liposomes and to Ricin-A-chain via the Lys₁₁ residue without significant loss of biological activity. The resulting conjugates were found to bind to Bl6 melanoma cells which express receptors for the hormone. Hormone targeted ricin was shown to be toxic to the cells, indicating receptor mediated interna
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24

Foing, Muriel. "Les méthodes d'étude des liposomes en cosmétologie." Paris 5, 1992. http://www.theses.fr/1992PA05P016.

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25

Mozuraityte, Revilija. "Oxidation of marine phospholipids in liposomes." Doctoral thesis, Norwegian University of Science and Technology, Department of Biotechnology, 2007. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-2008.

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<p>Marine phospholipids contain a high amount of n-3 polyunsaturated fatty acids (PUFAs), which have documented beneficial effect on human health. Due to this, marine phospholipids have a high potential for use in products for human consumption. However, due to the high amount of n-3 PUFAs, marine phospholipids are very susceptible to lipid oxidation, which cause loss of sensory and nutritional value in foods, some oxidation compounds are even toxic. A successful incorporation of marine phospholipids in processed foods would most probably be in the form of lipid dispersions, where some common
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26

Oidu, Benjamin. "Uptake of liposomes into bacterial cells." Thesis, Nelson Mandela Metropolitan University, 2013. http://hdl.handle.net/10948/d1021010.

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Liposomes are small phospholipid vesicles that have been widely investigated as drug carriers for the delivery of therapeutic agents. A variety of liposome formulations are presently under clinical trial exploration, while others have already been approved for clinical use. The aim of this study was to optimize liposome uptake into bacterial cells. Both gram-positive and gram-negative bacteria were used in the study as well as Candida albicans.Response surface methodology (RSM) using a central composite design (CCD) model was used to optimize liposomal formulations of carboxyfluorescien (CF) f
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27

Royall, P. G. "Liposomes : partitioning and model drug systems." Thesis, University of Kent, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.300949.

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28

Jackson, S. M. "Deposition of liposomes on solid surfaces." Thesis, University of Manchester, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.377751.

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29

Perrie, Yvonne. "Liposomes as a gene delivery system." Thesis, University College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.312844.

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30

Patel, Brijesh Prakash. "Polymerised liposomes as intranasal vaccine adjuvants." Thesis, University College London (University of London), 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.415942.

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31

Hartley, Jonathan Michael. "Surface Modification of Liposomes Containing Nanoemulsions." BYU ScholarsArchive, 2011. https://scholarsarchive.byu.edu/etd/2846.

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Many attempts have been made to make cancer therapy more selective and less detrimental to the health of the patients. Nanoparticles have emerged as a way to solve some of the problems of traditional chemotherapy. Nanoparticles can provide protection for the therapeutic from degradation or clearance, as well as protection to healthy tissue from the damaging effects of chemotherapy drugs. Researchers are pursuing different strategies but all have the same goals of improving the outcomes of cancer patients. The field of controlled release of drugs has increased significantly in hopes of better t
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32

Škrabalová, Lada. "Hemoglobin-mediated oxidation of marine liposomes." Master's thesis, Vysoké učení technické v Brně. Fakulta chemická, 2012. http://www.nusl.cz/ntk/nusl-216833.

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Cílem této práce bylo studium mechanismu oxidace lipidů katalyzované hovězím methemoglobinem a zhodnocení účinků různých experimentálních podmínek a antioxidantů (EDTA, askorbová kyselina, kávová kyselina, a-tokoferol, d-tokoferol, astaxanthin a L-askorbyl-6-palmitát) na methemoglobinem zprostředkovanou oxidaci lipidů v modelovém systému liposomů připravených z fosfolipidů. K monitorování oxidace lipidů při pH 5,5 a teplotě 30 °C bylo použito spotřeby kyslíku. Pro zhodnocení antioxidační aktivity v modelovém systému liposomů se ukázaly být důležitými faktory typ prooxidantu a koncentrace proox
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33

CHESSA, MAURA. "Innovatives liposomes for overcoming biological barriers." Doctoral thesis, Università degli Studi di Cagliari, 2013. http://hdl.handle.net/11584/266227.

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In this thesis work were prepared and characterized liposomes and liposomes modified with a coating of chitosan called chitosomes. Through these structures were conveyed drugs of natural origin with anti-inflammatory and antioxidant properties: quercetin,phycocyanin and curcumin. The liposomes loading quercetin and phycocyanin are designed for a topical application and were tested on new born pig skin. Liposomes and chitosomes loading curcumin are designed for pulmonary delivery as a cure for cystic fibrosis. In this case, has been tested the toxicity of the system using a model of lung tissue
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34

Wild, Thomas Jacob. "Development of self organising size-limited liposomal clusters using asymmetric Janus-textured liposomes and DNA-amphiphiles." Thesis, University of Leeds, 2017. http://etheses.whiterose.ac.uk/18331/.

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Current technologies focus on the use of single drug delivery carriers delivering a single drug species, or multiple species, in a compromisingly loaded or damaged state. Here we aim to develop controlled liposome (vesicle) clusters as potential multi-drug carriers for applications in nanomedicine. Specifically; applications include but are not limited to, combinational therapeutics and for the simultaneous delivery of prodrug and complementary activating enzyme. To this end, we are utilising a platform where different liposomes can be connected through DNA linkers, in hope to deliver multiple
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35

Trébaol, Annai͏̈ck. "Etude préléminaire "in vitro" de l'activité antiseptique de la chlorhéxidine sous forme liposomale en vue d'une utilisation en odonto-stomatologie." Paris 5, 1993. http://www.theses.fr/1993PA05P267.

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36

Vincourt-Vitse, Véronique. "Contribution à la formulation et à l'évaluation de liposomes d'ATP." Thesis, Paris 5, 2012. http://www.theses.fr/2012PA05P651/document.

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Les liposomes d’ATP incluant des ligands hépatiques pourraient contribuer à améliorer le statut énergétique du greffon hépatique. Une première phase de développement a mis en évidence la nécessité de stabiliser la forme (i) et de valider un modèle cellulaire à statut énergétique altéré (ii) afin de pouvoir tester différentes formulations liposomales d’intérêt. Afin de résoudre la première problématique, différentes stratégies ont été mises en place lors de la lyophilisation de liposomes blancs ou chargés en ATP. Le saccharose et le tréhalose ont conduit à une stabilisation de la forme avant et
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37

Bleher, Stefan [Verfasser], Regine [Akademischer Betreuer] Süss, and Rolf [Akademischer Betreuer] Schubert. "Evaluation of novel lipopolymers to impart stealth-like properties to liposomes = Untersuchung neuer Lipopolymere zur Zirkulationszeitverlängerung von Liposomen." Freiburg : Universität, 2019. http://d-nb.info/1202010792/34.

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38

Liu, Xin. "Fliposomes: pH-sensitive liposomes comprising novel trans-2-aminocyclohexanol-based amphiphiles as conformational switches for the liposome mebrane." Scholarly Commons, 2013. https://scholarlycommons.pacific.edu/uop_etds/149.

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As a promising pH-triggerable molecular switch, trans -2-aminocyclohexanol (TACH) has a variety of applications. By introducing two hydrocarbon tails, multiple TACH-based lipids (flipids) have been designed and studied that are able to perform a drastic conformational flip upon protonation, loosening the stacking of hydrocarbon tails in lipid bilayers. Liposomes constructed from such flipids (fliposomes) can be disrupted by this acid-triggered conformational flip to cause a rapid release of a cargo specifically in areas of increased acidity (such as inflammation or ischemic tissues, solid tumo
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39

Lejoyeux, Pierre. "Interaction d'une série alkyloxazolopyridocarbazole avec des liposomes : étude thermodynamique et cinétique." Paris 5, 1989. http://www.theses.fr/1989PA05P009.

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40

Wessman, Per. "Physico-Chemical Investigations of, and Characterization of Model Membranes for, Lipid-Peptide Interactions." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-89432.

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41

Kumar, Krishna Nandan. "Acoustic Studies on Nanodroplets, Microbubbles and Liposomes." Thesis, The George Washington University, 2017. http://pqdtopen.proquest.com/#viewpdf?dispub=10639706.

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<p> Microbubbles and droplets are nanometer to micron size biocompatible particles which are primarily used for drug delivery and contrast imaging. Our aim is to broaden the use of microbubbles from contrast imaging to other applications such as measuring blood pressure. The other goal is to develop in situ contrast agents (phase shift droplets) which can be used for applications such as cancer tumor imaging. Therefore, the focus is on developing and validating the concept using experimental and theoretical methods. Below is an overview of each of the projects performed on droplets and microbu
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42

Tarasova, Anna Optometry UNSW. "Fabrication and characterisation of affinity-bound liposomes." Awarded by:University of New South Wales. Optometry, 2007. http://handle.unsw.edu.au/1959.4/29114.

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In considering the concept of surface-immobilised liposomes as a drug release system, two factors need to addressed, the interfacial surface density of the liposomes for maximum drug loading and the stability of these liposomes to allow for controlled drug release. This thesis investigates a multilayer system for the affinity immobilisation of liposomes and their stability to various applied stresses. In the work presented here an allylamine monomer was used to create plasma coatings that were stable, thin and amine-rich. The aging studies using AFM showed these films to rapidly oxidise on exp
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43

Xiang, Gail Ke. "Study of non-polymerized and polymerized liposomes." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp05/mq24948.pdf.

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44

Parkinson, Claire Louise. "Functionalised PDA liposomes as biosensors for proteins." Thesis, University of Glasgow, 2010. http://theses.gla.ac.uk/2499/.

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A synthetic membrane is an organized supramolecular membrane that encompasses molecular recognition with signal transduction analogous to a natural biosensing system in a cell membrane. These synthetic based models allow the study and application of receptor-ligand binding to biosensor design. In order to enable a recognition event and a response the liposome incorporates a known ligand with a suitable receptor interaction that upon complementary binding can elicit a measurable response. Polydiacetylene based sensors have been previously considered and utilised for the detection of biologicall
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45

Dutta, Rinku. "Detection of Metalloenzymes Employing Fluorescentpolymers and Liposomes." Diss., North Dakota State University, 2012. https://hdl.handle.net/10365/26636.

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In the biological systems, proteins are important constituents. Protein-protein interactions play vital roles in physiological environments and any disruption in these interactions lead to adverse effects. However, designing artificial receptor molecules or scaffolds to imitate or replace these endogenous partners could be an avenue for better drug designing and detection tools creation. We are primarily interested in polymer and liposomal systems to detect two crucial metalloenzymes of the living world. Matrix metalloproteinases are zinc-containing endopeptidases which are required for wound
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46

Pajean, Muriel. "Stabilisation de liposomes en présence de collagène." Lyon 1, 1992. http://www.theses.fr/1992LYO10036.

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Les liposomes sont consideres dans les domaines pharmaceutiques comme de nouvelles formes d'administration permettant un relargage programme ou dirige de principes actifs. Cependant a ce jour, le developpement de produits finis a base de liposomes reste limite face aux problemes poses par la stabilite et la conservation de ces vesicules. La recherche d'une stabilisation optimale in vitro de liposomes places ou non au sein d'une matrice collagenique a donc ete entreprise. Lors de cette etude, nous avons montre un effet stabilisateur du collagene sur la permeabilite liposomiale: la fuite de carb
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47

Podaru, George. "Exploring controlled drug release from magneto liposomes." Diss., Kansas State University, 2017. http://hdl.handle.net/2097/35544.

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Doctor of Philosophy<br>Department of Chemistry<br>Viktor Chikan<br>This thesis focuses on exploring fast and controlled drug release from several liposomal drug delivery systems including its underlying mechanics. In addition, the construction of a pulsed high-voltage rotating electromagnet is demonstrated based on a nested Helmholtz coil design. Although lots of different drug delivery mechanisms can be used, fast drug delivery is very important to utilize drug molecules that are short-lived under physiological conditions. Techniques that can release model molecules under physiological condi
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48

Ran, Yingqing. "Applications of liposomes on anti-cancer agents." Diss., The University of Arizona, 2004. http://hdl.handle.net/10150/290047.

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Toxicity is a major limitation in clinical use of most anticancer drugs. Liposomes, especially targeted long-circulating liposomes, provide the possibility of delivering drugs specifically to targeted cancer tissues, thus increasing anticancer activity and minimizing toxicity. 2-4'-Amino-3'-methylphenylbenzothiazole (AMPB), a potent anticancer drug, is inappropriate for traditional oral or parenteral formulations because of its severe dose-limiting hepatotoxicity. Several PEG-coated liposomal formulations were developed by using different drug/lipid ratios. Particle size and encapsulation effi
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49

Taylor, Bradley Jay. "Development and Characterization of Eukaryotic Biomimetic Liposomes." DigitalCommons@USU, 2004. https://digitalcommons.usu.edu/etd/5508.

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This study developed and characterized phospholipid vesicles, or liposomes, that mimic cell surfaces. Microemulsified liposomes contained biotinylated phosphatidylethanolamine, allowing them to be immobilized to avidin-coated glass. Laminin (LN), glycosphingolipids (GMl and GM3), and Escherichia coli's mechanosensitive channel of large conductance (EcoMscL) were embedded into liposome membranes. It was determined whether these embedded molecules exhibited their physiological roles of adhesion, cell recognition, and mechanosensation, respectively. Confocal laser scanning microscopy (CLSM) was e
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50

SCHLICH, MICHELE. "Liposomes for siRNA and small molecule delivery." Doctoral thesis, Università degli Studi di Cagliari, 2017. http://hdl.handle.net/11584/249594.

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In the last decades, liposomes have been extensively investigated as carriers for the delivery of a wide range of pharmaceutically active compounds and macromolecules, with the aim of modifying and improving their biopharmaceutical properties. In this work, the design and development of nano structured liposomal vehicles for the delivery of short interfering RNAs (siRNAs) and antiinflammatory agents is presented. Specifically, in the first section, different types of liposomes, including the appropriate surface modification with peptidic or small molecules targeting agents, have been designe
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