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Journal articles on the topic 'Liposomes'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Al Badri, Yaqeen Nadheer, Cheng Shu Chaw, and Amal Ali Elkordy. "Insights into Asymmetric Liposomes as a Potential Intervention for Drug Delivery Including Pulmonary Nanotherapeutics." Pharmaceutics 15, no. 1 (2023): 294. http://dx.doi.org/10.3390/pharmaceutics15010294.

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Liposome-based drug delivery systems are nanosized spherical lipid bilayer carriers that can encapsulate a broad range of small drug molecules (hydrophilic and hydrophobic drugs) and large drug molecules (peptides, proteins, and nucleic acids). They have unique characteristics, such as a self-assembling bilayer vesicular structure. There are several FDA-approved liposomal-based medicines for treatment of cancer, bacterial, and viral infections. Most of the FDA-approved liposomal-based therapies are in the form of conventional “symmetric” liposomes and they are administered mainly by injection.

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Ishida, Tatsuhiro, Hideyoshi Harashima, and Hiroshi Kiwada. "Liposome Clearance." Bioscience Reports 22, no. 2 (2002): 197–224. http://dx.doi.org/10.1023/a:1020134521778.

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The clearance rate of liposomal drugs from the circulation is determined by the rate and extent of both drug release and uptake of liposomes by cells of the mononuclear phagocyte system (MPS). Intravenously injected liposomes initially come into contact with serum proteins. The interaction of liposomes with serum proteins is thought to play a critical role in the liposome clearance. Therefore, in this review, we focus on the role of serum proteins, so-called opsonins, that enhance the clearance of liposomes, when bound to liposomes. In addition to opsonin-dependent liposome clearance, opsonin-

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Yanagihara, Shin, Yukiya Kitayama, Eiji Yuba, and Atsushi Harada. "Preparing Size-Controlled Liposomes Modified with Polysaccharide Derivatives for pH-Responsive Drug Delivery Applications." Life 13, no. 11 (2023): 2158. http://dx.doi.org/10.3390/life13112158.

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The liposome particle size is an important parameter because it strongly affects content release from liposomes as a result of different bilayer curvatures and lipid packing. Earlier, we developed pH-responsive polysaccharide-derivative-modified liposomes that induced content release from the liposomes under weakly acidic conditions. However, the liposome used in previous studies size was adjusted to 100–200 nm. The liposome size effects on their pH-responsive properties were unclear. For this study, we controlled the polysaccharide-derivative-modified liposome size by extrusion through polyca

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Cattel, Luigi, Maurizio Ceruti, and Franco Dosio. "From Conventional to Stealth Liposomes a new Frontier in Cancer Chemotherapy." Tumori Journal 89, no. 3 (2003): 237–49. http://dx.doi.org/10.1177/030089160308900302.

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Many attempts have been made to achieve good selectivity to targeted tumor cells by preparing specialized carrier agents that are therapeutically profitable for anticancer therapy. Among these, liposomes are the most studied colloidal particles thus far applied in medicine and in particular in antitumor therapy. Although they were first described in the 1960s, only at the beginning of 1990s did the first therapeutic liposomes appear on the market. The first-generation liposomes (conventional liposomes) comprised a liposome-containing amphotericin B, Ambisome (Nexstar, Boulder, CO, USA), used a

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Kumar, Amit, Madhu Gupta, and Simran Braya. "Liposome Characterization, Applications and Regulatory landscape in US." International Journal of Drug Regulatory Affairs 9, no. 2 (2021): 81–89. http://dx.doi.org/10.22270/ijdra.v9i2.474.

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Liposomes are lipid based drug carrier whose therapeutic performance depends on their structure. Liposomes offer several advantages over the conventional drug like target drug delivery, reduced toxicity, and extended pharmacokinetics. Characterization and Identification of critical attribute of liposomal formulation and suitable strategies for control during product development is important for quality of the liposomal drug product. This paper discusses the current status of the liposomal drug product and strategy used in regulating liposome product. Despite of lack of regulatory guidelines ma

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Goins, Beth A., and William T. Phillips. "The Use of Scintigraphic Imaging During Liposome Drug Development." Journal of Pharmacy Practice 14, no. 5 (2001): 397–406. http://dx.doi.org/10.1106/da2m-fyju-1xxq-ppkk.

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Liposomes, spherical lipid bilayers enclosing an aqueous space, have become an important class of drug carriers. This review describes the usefulness of scintigraphic imaging during the development of liposome-based drugs. This imaging modality is particularly helpful for tracking the distribution of liposomes in the body, monitoring the therapeutic responses following administration of liposome-based drugs, and investigating the physiological responses associated with liposome administration. Scintigraphy also can be used to monitor the therapeutic responses of patients given approved liposom

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Marqués-Gallego, Patricia, and Anton I. P. M. de Kroon. "Ligation Strategies for Targeting Liposomal Nanocarriers." BioMed Research International 2014 (2014): 1–12. http://dx.doi.org/10.1155/2014/129458.

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Liposomes have been exploited for pharmaceutical purposes, including diagnostic imaging and drug and gene delivery. The versatility of liposomes as drug carriers has been demonstrated by a variety of clinically approved formulations. Since liposomes were first reported, research of liposomal formulations has progressed to produce improved delivery systems. One example of this progress is stealth liposomes, so called because they are equipped with a PEGylated coating of the liposome bilayer, leading to prolonged blood circulation and improved biodistribution of the liposomal carrier. A growing

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Al Mutairi, Amal Abdullah, and Mohsen Mahmoud Mady. "Biophysical Characterization of (DOX-NPtm): FTIR and DSC Studies." JOURNAL OF ADVANCES IN PHYSICS 20 (March 3, 2022): 41–47. http://dx.doi.org/10.24297/jap.v20i.9194.

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Doxorubicin loaded into liposomes grafted with polyethylene glycol (PEG) has been demonstrated to have a longer circulation time and lower cardiotoxicity than doxorubicin (DOX). This study aims to investigate the biophysical characterization of a marketed formulation DOX-encapsulated liposome (DOX-NPTM). The interactions between doxorubicin and liposomal lipids can help in liposomal development. The liposome and DOX-NPTM were characterized in terms of differential scanning calorimetry (DSC) and Fourier transform infrared spectroscopy (FTIR). The rheological properties of liposomal samples were

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9

Abbase, Eman R., Medhat W. Shafaa, and Mohsen M. Mady. "Competition Between Heparin and Polyethylene Glycol as Biofunctionalization for Improving Stability of Liposomal Doxorubicin." Advanced Science, Engineering and Medicine 12, no. 2 (2020): 271–77. http://dx.doi.org/10.1166/asem.2020.2496.

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In order to improve liposomal doxorubicin stability, differentiation between Heparin and Polyethylene Glycol (PEG) as biofunctionalization for liposomal doxorubicin has been investigated by measuring the entrapment efficiency, size distribution, zeta potential, evaluating the in vitro potential cytotoxicity against MCF-7 (Breast cancer cell) and stability in serum by measuring the drug release rate. We synthesized Four liposomal formulations: (A) Conventional liposomes; DPPC:DOX, (B) Positively charged PEGylated liposomes; DPPC:CHOL:SA:PEG:DOX (C) Negatively charged PEGylated liposomes: DPPC:C

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Heneweer, Carola, Tuula Peñate Medina, Robert Tower, et al. "Acid-Sphingomyelinase Triggered Fluorescently Labeled Sphingomyelin Containing Liposomes in Tumor Diagnosis after Radiation-Induced Stress." International Journal of Molecular Sciences 22, no. 8 (2021): 3864. http://dx.doi.org/10.3390/ijms22083864.

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In liposomal delivery, a big question is how to release the loaded material into the correct place. Here, we will test the targeting and release abilities of our sphingomyelin-consisting liposome. A change in release parameters can be observed when sphingomyelin-containing liposome is treated with sphingomyelinase enzyme. Sphingomyelinase is known to be endogenously released from the different cells in stress situations. We assume the effective enzyme treatment will weaken the liposome making it also leakier. To test the release abilities of the SM-liposome, we developed several fluorescence-b

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Maneri, Karishma Y* Inagle Sanjay Baride komal Latpate Manisha B. "Liposomal Nanomedicines In Cancer Therapy." International Journal of Pharmaceutical Sciences 2, no. 10 (2024): 1537–52. https://doi.org/10.5281/zenodo.13997934.

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As nanocarriers, liposomes have long been studied for their ability to deliver medications to their sites of action while lowering toxicity.Nanotechnology is among the most exciting new technologies of the twenty-first century.Phospholipids give liposomes their form. Anticancer medications, among other medications, can be delivered by liposome encapsulation. Liposomes can include both hydrophilic and hydrophobic medicines. Once closed lipid bilayer vesicles were discovered, the name liposomes was first used in 1960. As medication carriers, liposomes are helpful, but making them using organic s

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Yaroslavov, Alexander A., and Andrey V. Sybachin. "Multifunctional carriers for controlled drug delivery." Pure and Applied Chemistry 92, no. 6 (2020): 919–39. http://dx.doi.org/10.1515/pac-2019-1111.

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AbstractIn the review we describe a method for concentration of anionic liposomes with encapsulated water-soluble substances within a small volume via electrostatic liposome adsorption on the surface of polymer particles with grafted cationic chains (spherical polycationic brushes), or cationic microgel particles. Dozens of intact liposomes can be bound to each polymer particle, the resulting polymer/liposome complex does not dissociate into the original components in a physiological solution. This allows fabrication of multi-liposomal complexes (MLCs) with a required ratio of encapsulated sub

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Shachi, Pandey*1 Alka Verma2 Arvind Singh3 Aman Kumar Singh4. "Liposomes: As An Important Drug Delivery System." International Journal in Pharmaceutical Sciences 2, no. 5 (2024): 1127–36. https://doi.org/10.5281/zenodo.11236835.

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Liposomes are cosidered as an important drug delivery system with lots of clinical applications. Important discovery in drug delivery system has been begins in 1950’s with the new research study of polyclonal antitumor antibodie. Liposomes are developed by Bangham and his colleagues in early 1960’s. The term liposomes mean lipid body. These are artificially prepared a simple microspic vesicle. These vesicles are made up of phospholipid and cholesterol. Several types of drugs can be filled in liposomal formulation according to the needs of patient. It is used to deliver the medicame

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Debs, R. J., N. Düzgüneş, E. N. Brunette, B. Fendly, J. Patton, and R. Philip. "Liposome-associated tumor necrosis factor retains bioactivity in the presence of neutralizing anti-tumor necrosis factor antibodies." Journal of Immunology 143, no. 4 (1989): 1192–97. http://dx.doi.org/10.4049/jimmunol.143.4.1192.

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Abstract Cell-associated TNF-alpha, either bound to its receptor on monocyte membranes or expressed as an integral membrane protein, can exert potent tumor cytolytic activity. We assessed the interaction of TNF with the lipid bilayer membrane system, liposomes, and the effects of membrane association on TNF bioactivity. High levels of TNF can be encapsulated within liposomes. At neutral pH, TNF binds to the surface of preformed liposomes (liposome-associated TNF), but does not partition into the lipid bilayer. TNF appears to bind to negatively charged phospholipid head groups of the outer memb

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Chavoshian, Omid, Mahdieh Arabsalmani, Mahmoud Reza Jaafari, et al. "A Phospholipase-A Activity in Soluble Leishmania Antigens Causes Instability of Liposomes." Current Drug Delivery 17, no. 9 (2020): 806–14. http://dx.doi.org/10.2174/1567201817666200731164002.

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Aim: This study aimed to investigate the existence of phospholipase-A (PLA) activity in Soluble L. major Antigens (SLA) because of no reports for it so far. Liposomes were used as sensors to evaluate PLA activity. Objective: Liposomal SLA consisting of Egg Phosphatidylcholine (EPC) or Sphingomyelin (SM) were prepared by two different methods in different pH or temperatures and characterized by Dynamic Light Scattering (DLS) and Thin Layer Chromatography (TLC). Methods: Lipid hydrolysis led to the disruption of EPC liposomal SLA in both methods but the Film Method (FM) produced more stable lipo

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Hattori, Yoshiyuki, Masataka Date, Shohei Arai, Kumi Kawano, Etsuo Yonemochi, and Yoshie Maitani. "Transdermal Delivery of Small Interfering RNA with Elastic Cationic Liposomes in Mice." Journal of Pharmaceutics 2013 (December 26, 2013): 1–6. http://dx.doi.org/10.1155/2013/149695.

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We developed elastic cationic liposomal vectors for transdermal siRNA delivery. These liposomes were prepared with 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP) as a cationic lipid and sodium cholate (NaChol) or Tween 80 as an edge activator. When NaChol or Tween 80 was included at 5, 10, and 15% (w/w) into DOTAP liposomal formulations (C5-, C10-, and C15-liposomes and T5-, T10-, and T15-liposomes), C15- and T10-liposomes showed 2.4- and 2.7-fold-higher elasticities than DOTAP liposome, respectively. Although the sizes of all elastic liposomes prepared in this study were about 80–90 nm, the

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Ayush, S. Jaiswal*1 Rekha Gaukande2 Gajanan Sanap3. "A Review On Liposomes As Drug Delivery System." International Journal in Pharmaceutical Sciences 1, no. 12 (2023): 926–36. https://doi.org/10.5281/zenodo.10442217.

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Liposomes are composed of phospholipids and lipids, forming spherical or multilayered vesicles with a lipid bilayer structure in aqueous solutions due to self-assembly of diacyl chain phospholipids. The number of bilayers and the size of vesicles influence the amount of drug encapsulation in liposomes, a crucial factor in determining their circulation half-life. This method involves coating a medication and a lipid onto a soluble carrier to create a pro-liposome, which is free-flowing and granular. When hydrated, it forms an isotonic liposomal solution. This pro-liposome approach serves as a m

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Sandal, Pallavi, Galal Mohsen Hussein Alsayadi, Abhishek Verma, Yash Choudhary, and Balak Das Kurmi. "Liposomal drug delivery: Recent developments and challenges." Pharmaspire 14, no. 01 (2022): 41–46. http://dx.doi.org/10.56933/pharmaspire.2022.14105.

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The spherical vesicles known as liposomes may contain one or many phospholipid bilayers. The first liposomes were found in the 1960s. One of the many distinctive drug delivery methods is the liposome, which offers a complex way to transfer active molecules to the site of action. Clinical trials are now testing a variety of formulations. Long-lasting second-generation liposomes are created by altering the vesicle’s lipid composition, size, and charge. Superficial vesicles have given way to liposome growth. Glycolipids and other substances have been used to make liposomes for the modification of

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Mursheda*1, Ajith Chandran2 Anagha S. Raj3 Jasnath. P. "Perspectives On Liposomes: Recent Developments, Clinical Uses, And Prospects." International Journal in Pharmaceutical Sciences 2, no. 7 (2024): 1073–84. https://doi.org/10.5281/zenodo.12739742.

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Liposomes are widely recognized as a significant nanoscale drug delivery method with appealing characteristics, including an easy-to-prepare bilayer structure that assembles the cellular membrane and high biocompatibility. Over the past few decades, a great deal of work has gone into developing liposome-based drug delivery systems. Numerous drug candidates have been investigated for their potential to reduce toxicity and prolong the duration of therapeutic effect by encapsulating them in liposomes. A growing number of liposomal-based therapeutics, with a variety of uses in antiviral, anticance

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Glukhova, Olga E. "Liposome Drug Delivery System across Endothelial Plasma Membrane: Role of Distance between Endothelial Cells and Blood Flow Rate." Molecules 25, no. 8 (2020): 1875. http://dx.doi.org/10.3390/molecules25081875.

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This paper discusses specific features of the interactions of small-diameter liposomes with the cytoplasmic membrane of endothelial cells using in silico methods. The movement pattern of the liposomal drug delivery system was modeled in accordance with the conditions of the near-wall layer of blood flow. Our simulation results show that the liposomes can become stuck in the intercellular gaps and even break down when the gap is reduced. Liposomes stuck in the gaps are capable of withstanding a shell deformation of ~15% with an increase in liposome energy by 26%. Critical deformation of the mem

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Umbarkar, Mahesh, Swapnil Thakare, Tanaji Surushe, Amol Giri, and Vaibhav Chopade. "Formulation and Evaluation of Liposome by Thin Film Hydration Method." Journal of Drug Delivery and Therapeutics 11, no. 1 (2021): 72–76. http://dx.doi.org/10.22270/jddt.v11i1.4677.

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Liposomes are the most advance formulation for targeting and controlled drug delivery system. These liposomes are generally administered by intra-venous route. In this work the liposome was prepared by using thin film hydration method. The formulated liposome is evaluated or characterised by using zeta sizer, Encapsulation efficiency, Entrapment efficiency, In vitro drug release. Main things are drug which are used for formulation of liposome was Diclofenac sodium, it having anti-inflammatory and anti-pyretic effect. The Diclofenac sodium having several adverse effects, such as depression of r

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Gorbik, V. S., Z. S. Shprakh, Z. M. Kozlova, and V. G. Salova. "LIPOSOMES AS A TARGETED DELIVERY SYSTEM OF DRUGS (REVIEW)." Russian Journal of Biotherapy 20, no. 1 (2021): 33–41. http://dx.doi.org/10.17650/1726-9784-2021-20-1-33-41.

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Liposomal targeted drug delivery makes it possible to achieve effective concentration in the target cell under various pathological conditions. The main advantage of liposomal particles is their biodegradability and immunological neutrality, which improves the safety profile of drugs. The review provides information on the composition of liposomes: the main component of the liposomal membrane is phospholipids, which provide its strength and protect from mechanical impacts. Liposomal particles are distinguished by the size and number of bilayer membranes, also secreted liposomes with a non‑lame

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Jian, Cheng-Bang, Xu-En Yu, Hua-De Gao та ін. "Liposomal PHD2 Inhibitors and the Enhanced Efficacy in Stabilizing HIF-1α". Nanomaterials 12, № 1 (2022): 163. http://dx.doi.org/10.3390/nano12010163.

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Prolyl hydroxylase domain-containing protein 2 (PHD2) inhibition, which stabilizes hypoxia-inducible factor (HIF)-1α and thus triggers adaptation responses to hypoxia in cells, has become an important therapeutic target. Despite the proven high potency, small-molecule PHD2 inhibitors such as IOX2 may require a nanoformulation for favorable biodistribution to reduce off-target toxicity. A liposome formulation for improving the pharmacokinetics of an encapsulated drug while allowing a targeted delivery is a viable option. This study aimed to develop an efficient loading method that can encapsula

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Kan, Pei, Chih-Wan Tsao, Ae-June Wang, Wu-Chou Su, and Hsiang-Fa Liang. "A Liposomal Formulation Able to Incorporate a High Content of Paclitaxel and Exert Promising Anticancer Effect." Journal of Drug Delivery 2011 (October 11, 2011): 1–9. http://dx.doi.org/10.1155/2011/629234.

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A liposome formulation for paclitaxel was developed in this study. The liposomes, composed of naturally unsaturated and hydrogenated phosphatidylcholines, with significant phase transition temperature difference, were prepared and characterized. The liposomes exhibited a high content of paclitaxel, which was incorporated within the segregated microdomains coexisting on phospholipid bilayer of liposomes. As much as 15% paclitaxel to phospholipid molar ratio were attained without precipitates observed during preparation. In addition, the liposomes remained stable in liquid form at 4 for at least

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Nalawade, Vishwajit, and Kunal Patil. "Liposome: A Novel Drug Delivery System." International Journal of Research Publication and Reviews 04, no. 01 (2022): 1795–801. http://dx.doi.org/10.55248/gengpi.2023.4148.

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Liposome was derived from two Greek words “Lipos meaning fat and Soma meaning body”. Liposome were spherical shaped vesicles consist of phospholipids and cholesterol. Due to their size hydrophobic and lipophilic character they are very promising system for drug delivery. This novel drug delivery system aims to target the drug directly to the site of action. Liposomes are very biocompatible and stable and have unique property to entrap both hydrophilic drug and lipophilic drug to its compartment and lead to controlled release effect. They are of 0.05- 5.0 micrometer in diameter. Liposomes are u

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Alkandari, Anfal M., Yasser M. Alsayed, and Atallah M. El-Hanbaly. "Enhanced Efficacy of Radiopharmaceuticals When Using Technetium-99m-Labeled Liposomal Agents: Synthesis and Pharmacokinetic Properties." Biomedicines 10, no. 11 (2022): 2994. http://dx.doi.org/10.3390/biomedicines10112994.

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Challenges posed by the retention of radiopharmaceuticals in unintended organs affect the quality of patient procedures when undergoing diagnostics and therapeutics. The aim of this study was to formulate a suitable tracer encapsulated in liposomes using different techniques and compounds to enhance the stability, uptake, clearance, and cytotoxic effect of the radiopharmaceutical. Cationic liposomes were prepared by a thin-film method using dipalmitoyl phosphatidylcholine (DPPC) and cholesterol. Whole-body gamma camera images were acquired of intravenously injected New Zealand rabbits. Additio

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Agrawal, Surendra S., Vrinda Baliga, and Vaishali Y. Londhe. "Liposomal Formulations: A Recent Update." Pharmaceutics 17, no. 1 (2024): 36. https://doi.org/10.3390/pharmaceutics17010036.

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Liposome-based drug delivery technologies have showed potential in enhancing medication safety and efficacy. Innovative drug loading and release mechanisms highlighted in this review of next-generation liposomal formulations. Due to poor drug release kinetics and loading capacity, conventional liposomes have limited clinical use. Scientists have developed new liposomal carrier medication release control and encapsulation methods to address these limits. Drug encapsulation can be optimized by creating lipid compositions that match a drug’s charge and hydrophobicity. By selecting lipids and addi

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Harokopakis, Evlambia, George Hajishengallis, and Suzanne M. Michalek. "Effectiveness of Liposomes Possessing Surface-Linked Recombinant B Subunit of Cholera Toxin as an Oral Antigen Delivery System." Infection and Immunity 66, no. 9 (1998): 4299–304. http://dx.doi.org/10.1128/iai.66.9.4299-4304.1998.

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ABSTRACT Liposomes appear to be a promising oral antigen delivery system for the development of vaccines against infectious diseases, although their uptake efficiency by Peyer’s patches in the gut and the subsequent induction of mucosal immunoglobulin A (IgA) responses remain a major concern. Aiming at targeted delivery of liposomal immunogens, we have previously reported the conjugation via a thioether bond of the GM1 ganglioside-binding subunit of cholera toxin (CTB) to the liposomal outer surface. In the present study, we have investigated the effectiveness of liposomes containing the saliv

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Medina, Oula Peñate, Tuula Peñate Medina, Jana Humbert, et al. "Using Alendronic Acid Coupled Fluorescently Labelled SM Liposomes as a Vehicle for Bone Targeting." Current Pharmaceutical Design 26, no. 46 (2020): 6021–27. http://dx.doi.org/10.2174/1381612826666200614175905.

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Background: We recently developed a liposomal nanoparticle system that can be used for drug delivery and simultaneously be monitored by optical or photoacoustic imaging devices. Here we tested the efficacy of alendronate as a homing molecule in SM-liposomes for bone targeting. Methods: Alendronate was immobilized covalently on the liposomal surface and the fluorescent dye indocyanine green was used as a payload in the liposomes. The indocyanine green delivery was analyzed by 3D optical tomography, optical fluorescence scanner, photoacoustic imaging, and by ex-vivo biodistribution studies. Resu

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Nijen Twilhaar, Maarten K., Lucas Czentner, Joanna Grabowska, et al. "Optimization of Liposomes for Antigen Targeting to Splenic CD169+ Macrophages." Pharmaceutics 12, no. 12 (2020): 1138. http://dx.doi.org/10.3390/pharmaceutics12121138.

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Despite promising progress in cancer vaccination, therapeutic effectiveness is often insufficient. Cancer vaccine effectiveness could be enhanced by targeting vaccine antigens to antigen-presenting cells, thereby increasing T-cell activation. CD169-expressing splenic macrophages efficiently capture particulate antigens from the blood and transfer these antigens to dendritic cells for the activation of CD8+ T cells. In this study, we incorporated a physiological ligand for CD169, the ganglioside GM3, into liposomes to enhance liposome uptake by CD169+ macrophages. We assessed how variation in t

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Skupin-Mrugalska, Paulina, Philipp A. Elvang, and Martin Brandl. "Application of Asymmetrical Flow Field-Flow Fractionation for Characterizing the Size and Drug Release Kinetics of Theranostic Lipid Nanovesicles." International Journal of Molecular Sciences 22, no. 19 (2021): 10456. http://dx.doi.org/10.3390/ijms221910456.

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Liposome size and in vitro release of the active substance belong to critical quality attributes of liposomal carriers. Here, we apply asymmetric flow field-flow fractionation (AF4) to characterize theranostic liposomes prepared by thin lipid film hydration/extrusion or microfluidics. The vesicles’ size was derived from multi-angle laser light scattering following fractionation (AF4) and compared to sizes derived from dynamic light scattering measurements. Additionally, we adapted a previously developed AF4 method to study zinc phthalocyanine (ZnPc) release/transfer from theranostic liposomes.

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Akbari, Aezam, Azadeh Ghaffari, Fahimeh Haji-Ahmadi, et al. "Nanobody-functionalized liposomal doxorubicin: A novel strategy for angiogenesis suppression via VEGFR2 targeting." BioImpacts 15 (April 6, 2025): 30707. https://doi.org/10.34172/bi.30707.

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Introduction: Doxorubicin (DOX ) is a widely used first-line treatment for various cancers but causes toxicity. Targeted drug delivery systems, particularly DOX-encapsulated liposomes, show clinical success and lower toxicity. The abnormal angiogenesis in high-grade tumors, making it crucial to develop strategies that target this process in conjunction with chemotherapy. This study presents an innovative formulation of anti-VEGFR2-functionalized liposomal DOX, designed to reduce systemic drug release, enhance drug release and bioavailability at tumor sites, and reducing adverse effects, repres

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Mishra, Harshita, Vaishali Chauhan, Kapil Kumar, and Deepak Teotia. "A comprehensive review on Liposomes: a novel drug delivery system." Journal of Drug Delivery and Therapeutics 8, no. 6 (2018): 400–404. http://dx.doi.org/10.22270/jddt.v8i6.2071.

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Liposome was derived from two Greek words “Lipos meaning fat and Soma meaning body”. Liposome were spherical shaped vesicles consist of phospholipids and cholesterol. Due to their size hydrophobic and lipophilic character they are very promising system for drug delivery. This novel drug delivery system aims to target the drug directly to the site of action. Liposomes are very biocompatible and stable and have unique property to entrap both hydrophilic drug and lipophilic drug (amphiphatic nature) to its compartment and lead to controlled release effect. They are of 0.05- 5.0 micrometer in diam

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Gilbreath, M. J., D. L. Hoover, C. R. Alving, G. M. Swartz, and M. S. Meltzer. "Inhibition of lymphokine-induced macrophage microbicidal activity against Leishmania major by liposomes: characterization of the physicochemical requirements for liposome inhibition." Journal of Immunology 137, no. 5 (1986): 1681–87. http://dx.doi.org/10.4049/jimmunol.137.5.1681.

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Abstract Resident peritoneal macrophages from untreated mice develop potent microbicidal activity against amastigotes of Leishmania major after in vitro treatment with lymphokine (LK) from mitogen-stimulated spleen cells. LK-induced macrophage microbicidal activity was completely and selectively abrogated by treatment with phosphatidylcholine-phosphatidylserine (PC/PS) liposomes. Other macrophage effector functions (phagocytosis, tumoricidal activity) were unaffected, as was cytotoxicity by macrophages activated in vivo or by LK in vitro before liposome treatment. Activation factors in LK were

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Tansi, Felista L., Ronny Rüger, Ansgar M. Kollmeier, et al. "Targeting the Tumor Microenvironment with Fluorescence-Activatable Bispecific Endoglin/Fibroblast Activation Protein Targeting Liposomes." Pharmaceutics 12, no. 4 (2020): 370. http://dx.doi.org/10.3390/pharmaceutics12040370.

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Liposomes are biocompatible nanocarriers with promising features for targeted delivery of contrast agents and drugs into the tumor microenvironment, for imaging and therapy purposes. Liposome-based simultaneous targeting of tumor associated fibroblast and the vasculature is promising, but the heterogeneity of tumors entails a thorough validation of suitable markers for targeted delivery. Thus, we elucidated the potential of bispecific liposomes targeting the fibroblast activation protein (FAP) on tumor stromal fibroblasts, together with endoglin which is overexpressed on tumor neovascular cell

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Sivathanu, Dr S. Bhagavathy, Shivapriya G, and Shivapriya G. "Formulation, Characterization and In vitro Drug Delivery of Vitexin Loaded Liposomes." International Journal of Pharmaceutical Sciences and Nanotechnology 14, no. 2 (2021): 5364–71. http://dx.doi.org/10.37285/ijpsn.2021.14.2.2.

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Liposome is a spherical vesicle which contains atleast one lipid bilayer. Liposomes are used as a novel drug carriers because of its hydrophobic and hydrophilic nature, it has many advantages in the field of medical sciences. There are some other drug carriers like dendrimers, micelles, niosomes. Out of all, liposomes are considered to be the most promising agent for drug delivery. The uniqueness of liposome is when it is used as a pharmaceutical drug, it acts as a natural receptor. Thus it acts as an antigen and binds with the antibody (cancer cell) without causing any damage to the adjacent

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Xiao, Dexuan, and Ronghui Zhou. "Advances in the Application of Liposomal Nanosystems in Anticancer Therapy." Current Stem Cell Research & Therapy 16, no. 1 (2021): 14–22. http://dx.doi.org/10.2174/1574888x15666200423093906.

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Cancer is the disease with the highest mortality rate, which poses a great threat to people’s lives. Cancer caused approximately 3.4 million death worldwide annually. Surgery, chemotherapy and radiotherapy are the main therapeutic methods in clinical practice. However, surgery is only suitable for patients with early-stage cancers, and chemotherapy as well as radiotherapy have various side effects, both of which limit the application of available therapeutic methods. In 1965, liposome was firstly developed to form new drug delivery systems given the unique properties of nanoparticles, such as

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Jovanović, Aleksandra A., Bojana Balanč, Mina Volić, Ilinka Pećinar, Jelena Živković, and Katarina P. Šavikin. "Rosehip Extract-Loaded Liposomes for Potential Skin Application: Physicochemical Properties of Non- and UV-Irradiated Liposomes." Plants 12, no. 17 (2023): 3063. http://dx.doi.org/10.3390/plants12173063.

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In the present study, rosehip (Rosa canina L.) extract was successfully encapsulated in phospholipid liposomes using a single-step procedure named the proliposome method. Part of the obtained liposomes was subjected to UV irradiation and non-treated (native) and UV-irradiated liposomes were further characterized in terms of encapsulation efficiency, chemical composition (HPLC analysis), antioxidant capacity, particle size, PDI, zeta potential, conductivity, mobility, and antioxidant capacity. Raman spectroscopy as well as DSC analysis were applied to evaluate the influence of UV irradiation on

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Acharya, Basanta, and Viktor Chikan. "Pulse Magnetic Fields Induced Drug Release from Gold Coated Magnetic Nanoparticle Decorated Liposomes." Magnetochemistry 6, no. 4 (2020): 52. http://dx.doi.org/10.3390/magnetochemistry6040052.

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Magnetic nanoparticle-assisted drug release from liposomes is an important way to enhance the functionality/usefulness of liposomes. This work demonstrates an approach how to integrate magnetic nanoparticles with liposomes with the assistance of gold–thiol chemistry. The gold coated magnetic particles cover the thiolated liposomes from the outside, which removes the competition of the drug molecules and the triggering magnetic particles to free the inner space of the liposomes when compared to previous magneto liposome formulations. The liposome consists of dipalmitoyl phosphatidylcholine (DPP

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Dhillon, Anjali, RituVinay Singh, and Kishna Ram Senwar. "An Extensive Review on Novel Liposomes : Classification, Methodology, Characterization, Current Formulations." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 14, no. 03 (2024): 1842–52. http://dx.doi.org/10.25258/ijddt.14.3.83.

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Liposomes are vesicles consisting of a phospholipid, hydrophobic drug, hydrophobic tail, hydrophilic tail, cholesterol, targeting agents, positive and negatively charged lipids, and a drug encapsulated in the center of the phospholipid group having a spherical shape. The phospholipid consists of an equal number of aqueous membranes, making the liposomes an important nanocarrier for the drug delivery to the targeted site. Various liposome-based products have recently been approved and are in clinical trials. This review will discuss the structure, classification, types, and method of liposome p

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Maiti, Kuntal, Subhas Bhowmick, Pankaj Jain, Murlidhar Zope, Keyur Doshi, and Thennati Rajamannar. "Comparison of Physicochemical Properties of Generic Doxorubicin HCl Liposome Injection with the Reference Listed Drug." Anti-Cancer Agents in Medicinal Chemistry 18, no. 4 (2018): 597–609. http://dx.doi.org/10.2174/1871520617666171121124610.

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Background: Liposomal doxorubicin is widely used for treating ovarian cancer and Kaposi’s sarcoma. Encapsulation of doxorubicin in highly complex polyethylene glycol–coated (stealth) liposomes prolongs residence time and avoids the systemic toxicity associated with administration of the free drug. Small variations in physicochemical properties introduced during manufacture of liposomes can influence the payload of encapsulated drug, stability of liposomes under physiological conditions, and release of drug at the target tissue. Accordingly, the US Food and Drug Administration and the European

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Adhikari, Chandan. "Liposomes-The 21st Century’s Drug Delivery System: Developments in the Last Two Decade." Asian Journal of Chemistry 35, no. 12 (2023): 2845–69. http://dx.doi.org/10.14233/ajchem.2023.30191.

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Liposomes have been thoroughly investigated and are utilized for various illnesses for the past few decades starting from its first discovery in 1961. Since then, therapeutic efficiency of liposomes is enhanced by increasing drug absorbance while fast deterioration and adverse effects are avoided or minimized. This will extend the biological halfway life. Liposomes are more attractive for usage as drug delivery carriers with all of these characteristics and versatility to modify their surface to create additional specific functionalities. In various phases of research, there are numerous new l

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Damm, Dominik, Ehsan Suleiman, Hannah Theobald, et al. "Design and Functional Characterization of HIV-1 Envelope Protein-Coupled T Helper Liposomes." Pharmaceutics 14, no. 7 (2022): 1385. http://dx.doi.org/10.3390/pharmaceutics14071385.

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Functionalization of experimental HIV-1 virus-like particle vaccines with heterologous T helper epitopes (T helper VLPs) can modulate the humoral immune response via intrastructural help (ISH). Current advances in the conjugation of native-like HIV-1 envelope trimers (Env) onto liposomes and encapsulation of peptide epitopes into these nanoparticles renders this GMP-scalable liposomal platform a feasible alternative to VLP-based vaccines. In this study, we designed and analyzed customizable Env-conjugated T helper liposomes. First, we passively encapsulated T helper peptides into a well-charac

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Boafo, George Frimpong, Kosheli Thapa Magar, Marlene Davis Ekpo, Wang Qian, Songwen Tan, and Chuanpin Chen. "The Role of Cryoprotective Agents in Liposome Stabilization and Preservation." International Journal of Molecular Sciences 23, no. 20 (2022): 12487. http://dx.doi.org/10.3390/ijms232012487.

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To improve liposomes’ usage as drug delivery vehicles, cryoprotectants can be utilized to prevent constituent leakage and liposome instability. Cryoprotective agents (CPAs) or cryoprotectants can protect liposomes from the mechanical stress of ice by vitrifying at a specific temperature, which forms a glassy matrix. The majority of studies on cryoprotectants demonstrate that as the concentration of the cryoprotectant is increased, the liposomal stability improves, resulting in decreased aggregation. The effectiveness of CPAs in maintaining liposome stability in the aqueous state essentially de

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Yue, Xiuli, and Zhifei Dai. "Liposomal Nanotechnology for Cancer Theranostics." Current Medicinal Chemistry 25, no. 12 (2018): 1397–408. http://dx.doi.org/10.2174/0929867324666170306105350.

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Liposomes are a type of biomimetic nanoparticles generated from self-assembling concentric lipid bilayer enclosing an aqueous core domain. They have been attractive nanocarriers for the delivery of many drugs (e.g. radiopharmaceuticals, chemotherapeutic agents, porphyrin) and diagnostic agents (e.g. fluorescent dyes, quantum dots, Gadolinium complex and Fe3O4) by encapsulating (or adsorbing) hydrophilic one inside the liposomal aqueous core domain (or on the bilayer membrane surface), and by entrapping hydrophobic one within the liposomal bilayer. Additionally, the liposome surface can be easi

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Rudnicka, Katarzyna, Paulina Lemieszek, Katarzyna Krukar, et al. "Targeted Cancer Therapy: The Role of Liposomes in Oncology. A Literature Review." Journal of Education, Health and Sport 69 (October 2, 2024): 55349. http://dx.doi.org/10.12775/jehs.2024.69.55349.

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Liposomal formulations represent a significant advancement in the field of oncology, providing innovative solutions for the delivery of chemotherapeutic agents. These nanoscale carriers, made of phospholipid bilayers, enhance drug stability and allow for targeted delivery to tumor tissues, thereby improving the therapeutic index of anticancer medications. By altering the pharmacokinetics and biodistribution of these drugs, liposomes help reduce systemic side effects while increasing the concentration of therapeutic agents at the tumor site. Recent developments in liposomal technology have led

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Borkar, Gauri, and Satyam Chemate. "Formulation Development and Evaluation Studies of Linezolid Inhaler in the Treatment of Tuberculosis." International Journal of Pharmaceutical Sciences and Drug Research 15, no. 06 (2023): 722–29. http://dx.doi.org/10.25004/ijpsdr.2023.150605.

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The primary objective of this study was to prepare and evaluate a linezolid inhaler. Dry powder inhaler liposomes were formulated to investigate the efficacy of pulmonary delivery of linezolid for tuberculosis. The liposomes were prepared using soya lecithin and cholesterol in different weight ratios, constant amounts of drugs, and two methods: physical dispersion and ethanol injection. The F9 formulation was characterized for physical and chemical properties such as vesicle size, shape, and zeta potential. The results of physical characterization, in-vitro testing, and stability studies indic

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Deol, P., G. K. Khuller, and K. Joshi. "Therapeutic efficacies of isoniazid and rifampin encapsulated in lung-specific stealth liposomes against Mycobacterium tuberculosis infection induced in mice." Antimicrobial Agents and Chemotherapy 41, no. 6 (1997): 1211–14. http://dx.doi.org/10.1128/aac.41.6.1211.

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One recent promising development in the modification of drug formulations to improve chemotherapy is the use of a liposome-mediated drug delivery system. The efficacies of isoniazid and rifampin encapsulated in lung-specific stealth liposomes were evaluated by injecting liposomal drugs and free drugs into tuberculous mice twice a week for 6 weeks. Liposome-encapsulated drugs at and below therapeutic concentrations were more effective than free drugs against tuberculosis, as evaluated on the basis of CFUs detected, organomegaly, and histopathology. Furthermore, liposomal drugs had marginal hepa

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Saito, Shoji, Ikumi Nakashima, Aiko Hasegawa, et al. "Tumor-Tropic Liposome-Mediated Therapeutic Delivery of mRNA for T Cell Malignancies." Blood 136, Supplement 1 (2020): 21–22. http://dx.doi.org/10.1182/blood-2020-139020.

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Introduction : Treatment options for relapsed T cell leukemia are limited, and the prognosis remains dismal. Therefore, the development of new therapies is crucial. A liposomal delivery system has been increasingly recognized as a promising strategy for delivering both reagents and nucleic acids. However, little is known about whether the liposomal delivery of mRNA could be employed for cancer treatment. Herein, we propose a novel strategy for the treatment of T cell malignancies using tumor-tropic liposomes that can selectively deliver mRNAs of interest to leukemia cells. Methods: We tested l

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Jiang, Yanhao, Wenpan Li, Zhiren Wang, and Jianqin Lu. "Lipid-Based Nanotechnology: Liposome." Pharmaceutics 16, no. 1 (2023): 34. http://dx.doi.org/10.3390/pharmaceutics16010034.

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Over the past several decades, liposomes have been extensively developed and used for various clinical applications such as in pharmaceutical, cosmetic, and dietetic fields, due to its versatility, biocompatibility, and biodegradability, as well as the ability to enhance the therapeutic index of free drugs. However, some challenges remain unsolved, including liposome premature leakage, manufacturing irreproducibility, and limited translation success. This article reviews various aspects of liposomes, including its advantages, major compositions, and common preparation techniques, and discusses

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