Relevant bibliographies by topics / Lipoxygenase inhibitory activity

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Academic literature on the topic 'Lipoxygenase inhibitory activity'

Author: Grafiati
Published: 3 June 2025
Last updated: 31 July 2025

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Journal articles on the topic "Lipoxygenase inhibitory activity"

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CHEN, Ching-Jiunn, Hui-Sheng HUANG, Yu-Tsong LEE, Chia-Yi YANG, and Wen-Chang CHANG. "Characterization and purification of a lipoxygenase inhibitor in human epidermoid carcinoma A431 cells." Biochemical Journal 327, no. 1 (1997): 193–98. http://dx.doi.org/10.1042/bj3270193.

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A lipoxygenase inhibitor in the cytosolic fraction of human epidermoid carcinoma A431 cells was characterized and purified. The cytosolic inhibitor lost the inhibitory activity upon heating at 75 °C for 15 min or pretreating with 1 mg/ml trypsin at 37 °C for 60 min. Cytosol, after dialysis, lost the inhibitory activity but its inhibitory activity recovered when 1 mM GSH was added to the dialysate. The inhibitory activity of cytosol was also abolished by treatment either with 1 mM iodoacetate at 4 °C for 1 h or with 0.5 mM H2O2. The pI of the inhibitor was approx. 7.0. In addition to 12-lipoxyg
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Boudreau, Luc H., Grégoire Lassalle-Claux, Marc Cormier, et al. "New Hydroxycinnamic Acid Esters as Novel 5-Lipoxygenase Inhibitors That Affect Leukotriene Biosynthesis." Mediators of Inflammation 2017 (2017): 1–12. http://dx.doi.org/10.1155/2017/6904634.

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Leukotrienes are inflammatory mediators that actively participate in the inflammatory response and host defense against pathogens. However, leukotrienes also participate in chronic inflammatory diseases. 5-lipoxygenase is a key enzyme in the biosynthesis of leukotrienes and is thus a validated therapeutic target. As of today, zileuton remains the only clinically approved 5-lipoxygenase inhibitor; however, its use has been limited due to severe side effects in some patients. Hence, the search for a better 5-lipoxygenase inhibitor continues. In this study, we investigated structural analogues of
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Goodwin, J. S., and D. Atluru. "Mechanism of action of glucocorticoid-induced immunoglobulin production: role of lipoxygenase metabolites of arachidonic acid." Journal of Immunology 136, no. 9 (1986): 3455–60. http://dx.doi.org/10.4049/jimmunol.136.9.3455.

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Abstract Glucocorticoids stimulate polyclonal immunoglobulin (Ig) production in cultures of human peripheral blood lymphocytes. The mechanism of action of glucocorticoids in this system, and indeed in any physiologic system, is unknown. Because glucocorticoids stimulate the production of phospholipase A2-inhibitory glycoproteins, we investigated whether glucocorticoids stimulate polyclonal Ig production by inhibition of arachidonic acid metabolism. Nonspecific lipoxygenase/cyclooxygenase inhibitors stimulate polyclonal Ig production in a manner similar to the effect of glucocorticoids, whereas
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Hadjipavlou-Litina, D., S. E. Bariamis, M. Militsopoulou, C. M. Athanassopoulos, and D. Papaioannou. "Trioxsalen derivatives with lipoxygenase inhibitory activity." Journal of Enzyme Inhibition and Medicinal Chemistry 24, no. 6 (2009): 1351–56. http://dx.doi.org/10.3109/14756360902932776.

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Carter, G. W., P. R. Young, D. H. Albert, et al. "5-lipoxygenase inhibitory activity of zileuton." Journal of Pharmacology and Experimental Therapeutics 256, no. 3 (1990): 929–37. https://doi.org/10.1016/s0022-3565(25)23086-5.

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Ha, Tae Joung, Ken-ichi Nihei, and Isao Kubo. "Lipoxygenase Inhibitory Activity of Octyl Gallate." Journal of Agricultural and Food Chemistry 52, no. 10 (2004): 3177–81. http://dx.doi.org/10.1021/jf034925k.

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Ha, Tae Joung, and Isao Kubo. "Lipoxygenase Inhibitory Activity of Anacardic Acids." Journal of Agricultural and Food Chemistry 53, no. 11 (2005): 4350–54. http://dx.doi.org/10.1021/jf048184e.

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Ha, Tae Joung, Kuniyoshi Shimizu, and Isao Kubo. "Lipoxygenase inhibitory activity of alkyl protocatechuates." Food Chemistry 159 (September 2014): 471–76. http://dx.doi.org/10.1016/j.foodchem.2014.03.037.

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Lončarić, Melita, Ivica Strelec, Valentina Pavić, Domagoj Šubarić, Vesna Rastija, and Maja Molnar. "Lipoxygenase Inhibition Activity of Coumarin Derivatives—QSAR and Molecular Docking Study." Pharmaceuticals 13, no. 7 (2020): 154. http://dx.doi.org/10.3390/ph13070154.

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Lipoxygenases (LOXs) are a family of enzymes found in plants, mammals, and microorganisms. In animals and plants, the enzyme has the capability for the peroxidation of unsaturated fatty acids. Although LOXs participate in the plant defense system, the enzyme’s metabolites can have numerous negative effects on human health. Therefore, many types of research are searching for compounds that can inhibit LOXs. The best quantitative structure–activity relationship (QSAR) model was obtained using a Genetic Algorithm (GA). Molecular docking was performed with iGEMDOCK. The inhibition of lipoxygenase
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Handayani, Nadya Febri, Berna Elya, and Nuraini Puspitasari. "CYCLEA BARBATA LEAF EXTRACT: LIPOXYGENASE INHIBITORY ACTIVITY AND PHYTOCHEMICAL SCREENING." International Journal of Applied Pharmaceutics 10, no. 1 (2018): 106. http://dx.doi.org/10.22159/ijap.2018.v10s1.22.

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Objective: The aim of this study was to test the anti-inflammatory activity of methanol, ethyl acetate, and n-hexane Cyclea barbata Mier. leaf extractsusing a lipoxygenase inhibition method.Methods: Enzyme activity assay was performed using colorimetric method with lipoxygenase from soybean and linoleic acid as a substrate.Absorbance was measured at 234 nm. The total flavonoid content of the most active extract was determined using a colorimetric method with AlCl3and phytochemical screening.Results: The ethyl acetate extract had the highest lipoxygenase inhibiting activity, with an IC50 value
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Dissertations / Theses on the topic "Lipoxygenase inhibitory activity"

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AMADIO, DANIELE. "Natural inhibitors of FAAH: a proposed mechanism for the modulation of their activity." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2009. http://hdl.handle.net/2108/862.

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Gli endocannabinoidi sono una classe di composti lipidici con funzioni neuro- ed immuno-modulatorie identificati di recente. Sono chiamati “endocannabinoidi” poiché sono in grado di legare ed attivare gli stessi recettori attivati dal Δ9-tetraidrocannabinolo (THC), il principio attivo dell’hashish e della marijuana. Nel corso degli ultimi anni sono stati individuati e caratterizzati diversi enzimi responsabili della biosintesi e della degradazione degli endocannabinoidi e ci si riferisce complessivamente a questi con il termine di “sistema endocannabinoide”. L’anandamide (AEA), uno degli endo
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Stoller, André. "Synthese d'analogues structuraux de l'acide arachidonique, inhibiteurs potentiels de la 5-lipoxygenase." Université Louis Pasteur (Strasbourg) (1971-2008), 1988. http://www.theses.fr/1988STR13165.

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Miranda, Margarida Isabel Silva Coutinho de. "5-Lipoxygenase inhibitors screening in plants extracts : a methodology evaluation and construction." Master's thesis, 2015. http://hdl.handle.net/10451/27043.

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Trabalho Final de Mestrado Integrado, Ciências Farmacêuticas, Universidade de Lisboa, Faculdade de Farmácia, 2015<br>This work presents a bibliographic review on the most used methods for 5-lipoxygenase activity assessment. This enzyme is responsible for leukotrien production, through the arachidonic acid pathway, and its role on physiopathological processes has been extensively reviewed. The experimental techniques for its detection and quantification, were described and their advantages and disadvantages were accounted for. They were further divided in continuous methods, where changes in th
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Book chapters on the topic "Lipoxygenase inhibitory activity"

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Roberts, P. J., A. R. Pizzey, and D. C. Linch. "The Effect of 5-Lipoxygenase Inhibitors on the Activity of IL-8." In Advances in Experimental Medicine and Biology. Springer US, 1993. http://dx.doi.org/10.1007/978-1-4615-2952-1_56.

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Hadjipavlou-Litina, Dimitra, and Eleni Pontiki. "Aryl-Acetic and Cinnamic Acids as Lipoxygenase Inhibitors with Antioxidant, Anti-inflammatory, and Anticancer Activity." In Advanced Protocols in Oxidative Stress III. Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-1441-8_26.

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Billaud, Catherine, Rebeca Garcia, Patrick Boivin, and Jacques Nicolas. "Evolution des activités lipoxygénasique et polyphénoloxydasique de différentes variétés d’orge au cours du maltage." In European Brewery Convention. Oxford University PressOxford, 1997. http://dx.doi.org/10.1093/oso/9780199636907.003.0019.

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Abstract Lipoxygenase (LOχ) and polyphenoloxidase (PPO) were measured in ten barley varieties during malting and kilning. A rapid method of determination is described, following separation of the two isoenzymes LOχ1 and LOχ2. LOχ3 showed preferential production in both barley and malt of a 9- hydroperoxide precursor of trans-2-nonenal, while LOX2, which appeared during germination, formed a 13-hydroperoxide. During kilning, variable quantities were formed of inhibitory compounds to LOχ, shown by dialysis before the estimation. PPO activity.
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Kobayashi, Naoyuki, Hirotaka Kaneda, Yukinobu Kano, and Shouhei Koshino. "Lipid oxidation during wort production." In European Brewery Convention. Oxford University PressOxford, 1993. http://dx.doi.org/10.1093/oso/9780199634668.003.0044.

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Abstract It has been reported that lipid oxidation during wort production has a relationship with flavour staling of beer. To clarify lipid oxidation mechanism during wort production, fatty acid hydroperoxides were analyzed using a chemiluminescence-HPLC method. The production of the hydroperoxides during mashing increased with lipoxygenase activity in malt. Adding an inhibitor of lipoxygenase to mash just before mashing or lowering pH in mash from 5.5 to 5.0 significantly inhibited the production of the hydroperoxides.
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Conference papers on the topic "Lipoxygenase inhibitory activity"

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Jansen, J. W. C. M. "EFFECTS OF INHIBITORS ON COLLAGEN INDUCED PLATELET AGGREGATION IN SIX DIFFERENT SPECIES." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643445.

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One approach to the development of antithrombotics is inhibition of platelet aggregation. The pharmacological approach often used is to test compounds on collagen induced platelet aggregation measured in platelet rich plasma. Therefore we have compared inhibitors with different mechanism of action on aggregation of platelets from six different species commonly used in pharmacological studies. Aggregation was induced with submaximal amounts of collagen (Hormone Chemie).Inhibitors of the cyclooxygenase system, aspirin and indomethacin, were very potent in inhibiting aggregation of platelets from
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De Clerck, F., R. Van de Wiele, B. Xhonneux, et al. "PLATELET TXA2 SYNTHETASE INHIBITION AND TXA2/PROSTAGLANDIN ENDOPEROXIDE RECEPTOR BLOCKADE COMBINED IN ONE MOLECULE (R 68070)." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643465.

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F 68070, an oxime-alkane carboxylic acid derivative (Janssen Pharmaceutica), is a potent inhibitor of thromboxane A2 (TXA2) synthetase activity (IC50 in vitro against thrombin-stimulated human platelets in plasma : R 68070 : 2.9 x 10-8 M; CGS 13080 : 6 x 10-8 M; OKY-1581 : 8.2 x 10-8 M; dazmegrel : 2.6 x 10-8 M; dazoxiben : 2.3 x 10-8 M).The compound specifically inhibits platelet TXA2 synthetase activity (14C-arachidonic acid metabolism by washed human platelets) without effect on the cyclo-oxygenase, lipoxygenase (platelets, RBL cells) or prostacyclin synthetase activities (rat aortic rings)
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Lumley, P., E. W. Collington, P. Hallett, et al. "THE EFFECTS OF GR32191, A NEW THROMBOXANE RECEPTOR BLOCKING DRUG,ON PLATELETS AND VASCULAR SMOOTH MUSCLE IN VITRO." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643754.

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The effect of a new thromboxane receptor blocking drug GR32191 ([1R-[1α(Z),2β,3β,5α]]-(+)-7-[5-[[(1,1"-biphenyl)-4-yl]methoxy] -3-hydroxy-2-(l-piperidinyl)cyclopentyl]-4-heptenoic acid,hydrochloride) has been examined upon platelets and vascular smooth muscle. In human platelet-rich plasma (PRP), aggregation to thromboxane(Tx) A2, PGH2, arachidonic acid, collagen andU-46619 was antagonised by GR32191 (IC50 range 2-36 nM).Primary aggregation (PRP treated with aspirin 10 pM) to ADP, 5-HT and adrenaline were unaffected by concentrations of GR32191 up to 10 pM. In human PRP, U-46619-induced aggreg
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Keta, Otilija, Jelena Bošković, Vladana Petković, et al. "Synthesis and cytotoxic activity of selected dual COX-2 and 5-LOX inhibitors in HeLa and MIA PaCa-2 human cancer cell lines." In 2nd International Conference on Chemo and Bioinformatics. Institute for Information Technologies, University of Kragujevac, 2023. http://dx.doi.org/10.46793/iccbi23.503k.

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Among novel cancer chemotherapy approaches, the use of cyclooxygenases (COXs) and lipoxygenases (LOXs) inhibitors represents a promising mean for cancer treatment showing lesser toxicity comparing to the currently used cytotoxic drugs. This study detailed the synthesis of three novel compounds: 1ME, BHTK-AA, and IBU-Ac, each with the capability to concurrently inhibit both COX-2 and 5-LOX. Subsequently, we assessed their effectiveness in inhibiting the proliferation of HeLa cervical and MIA PaCa-2 pancreatic cancer cells. The IC50 values for both examined cell lines were approximately 40 μM, i
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Zhuravlev, A. M., V. V. Aksenov, V. N. Gavrilyuk, A. B. Golovanov, and I. V. Ivanov. "ALLOSTERIC INHIBITORS OF ALOX15 BASED ON LIGANDS PROVIDING MULTIDIRECTIONAL REGULATION OF LINOLEIC AND ARACHIDONIC ACIDS." In X Международная конференция молодых ученых: биоинформатиков, биотехнологов, биофизиков, вирусологов и молекулярных биологов — 2023. Novosibirsk State University, 2023. http://dx.doi.org/10.25205/978-5-4437-1526-1-76.

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Mammalian 15-lipoxygenases (ALOX15) are enzymes of lipid peroxidation. The pathophysiological role of ALOX15 metabolites, linoleic acid and arachidonic acid derivatives, has made this enzyme a target for pharmacological studies. Several indole and benzimidazole derivatives inhibit the activity of ALOX15 in a substrate-specific manner, but the molecular basis of this allosteric inhibition remains unclear.
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Itagaki, Y., A. Suzuki, and K. Higashio. "TISSUE PLASMINOGEN ACTIVATOR (T-PA) PRODUCTION BY HUMAN EMBRYONIC FIBROBLASTS, IMR-90, STIMULATED BY PROTEOSE PEPTONE." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644392.

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In order to study the mechanisms by which t-PA production by IMR-90 cells are induced, lactalbumin hydrolysates, yeast extracts, and peptones were tested for their ability to induce t-PA production by IMR-90 cells. IMR-90 cells were grown to confluency in Dulbecco's modified Eagle's medium(DMEM) supplemented with 10% fetal calf serum at 37°C in 5% CO2 in air. And the cells were maintained in serum free medium containing 1% of each additive. The plasminogen activator activity was determined by fibrin plate method, using urokinase or t-PA from WHO as a standard. It was found that proteose pepton
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Tranquille, N., and J. J. Emeis. "LEUKOTRIENES INDUCE THE ACUTE RELEASE OF TISSUE-TYPE PLASMINOGEN ACTIVATOR FROM PERFUSED RAT BLOOD VESSEL WALLS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644387.

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In a previous publication (Blood 66, 86, 1985) we suggested, on the basis of inhibitor experiments, that lipoxygenase metabolites might be involved in the release of tissue-type plasminogen activator (t-PA) from vessel walls. To test this suggestion, isolated rat hindlegs were freed of blood with Tyrode-BSA solution, and subsequently perfused with Tyrode-BSA containing various lipoxygenase metabolites. The perfusate was collected at timed intervals and assayed for t-PA activity by a spectrophoto-metric procedure. Of the compounds tested (see Table) 5-HETE did not induce PA release. However, le
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Caebron, J. Y., M. Joseph, H. Vorng, J. Pincemail, M. Lagaede, and A. Capron. "OXYGEN FREE RADICAL-DEPENDENT STEP IN THE CYTOTOXICITY OF DEC-TREATED PLATELETS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1642819.

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Over the past 35 years, diethylcarbamazine (DEC) has been the most widely used agent for the treatment of filarial diseases. However, in spite of millions of individuals treated, the mode of action of this drug remained unexplained until recently when we reported that the microfilaricidal activity of DEC was mediated by blood platelets with the additional triggering of a filarial excretory antigen (FEA) (Nature, 1987).To set up the mechanism of the larvicidal action of platelets activatedby both DEC and FEA, various inhibitors of the arachidonic acid metabolism were added in the cytotoxic assa
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Reports on the topic "Lipoxygenase inhibitory activity"

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Prusky, Dov, Noel Keen, and Rolf Christoffersen. Involvement of Epicatechin in the Regulation of Natural Resistance of Avocado Fruit against Postharvest Pathogens. United States Department of Agriculture, 1997. http://dx.doi.org/10.32747/1997.7613028.bard.

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In this project it was found that the activation of the mechanism of resistance in avocado fruits to Colletotrichum gloeosporioides depends on the increase of the level of the preformed antifungal diene. This increase is regulated by the synthesis of the flavonoid epicatechin present in the fruit peel. Epicatechin is an inhibitor of the enzyme lipoxygenase whose activity catalyze the breakdown of the antifungal diene. Increase in epicatechin concentration inhibits the breakdown of the antifungal compound and since the compound is continuously synthesized, both combined processes result in the
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Prusky, Dov, Noel Keen, and John Browse. Modulation of the synthesis of the main preformed antifungal compound as abasis for the prevention of postharvest disease of C. gloeosporioides in avocado fruits. United States Department of Agriculture, 2001. http://dx.doi.org/10.32747/2001.7575273.bard.

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The most important pathological factor limiting fruit life after harvest in subtropical fruits are quiescent infections of anthracnose caused by Colletotrichum gloeosporioides. Prusky and Keen elucidated the mechanism of resistance in avocado fruits to quiescent infections of C. gloeosporioides and determined that the major biocide involved is the preformed compound,1-acetoxy-2-hydroxy-4-oxo-heneicosa-13, 15 diene. Two possibilities exist for maintaining fungitoxic levels of antifungal compounds in the tissue of ripening fruits: (i). Prevention of catabolism (ii). Induction of synthesis. Previ
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