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Journal articles on the topic 'Lippia thymoid'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

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1

Ibrain, Narlei Oliveira de Souza, de Nazaré Mota Araujo Brito Lígia, Tavares Vilhena Amajucy, Resque Beckemann Carvalho Tabata, Algusto Fernandes de Menezes Silvio, and Roberto de Souza Fonseca Ricardo. "PLANTA MEDICINAL DA AMAZÔNIA UTILIZADA EM CEPA PADRÃO DE CÂNDIDA ALBICANS." REVISTA FT 27, no. 127 (2023): 63. https://doi.org/10.5281/zenodo.10080863.

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<strong>Objetivo: </strong>Avaliar a sensibilidade e a concentração inibitória mínima (CIM) frente à cepa padrão de <i>Candida albicans</i> por meio de microdiluições seriadas do extrato Lippia thymoide testando sua ação fungicida. <strong>Métodos:</strong> Foi realizado estudo experimental, o óleo essencial foi obtido por hidrodestilação e analisado por Cromatografia de Fase Gasosa/Espectrometria de Massas (CG/EM), a cepa padrão testada foi Candida albicans por meio da técnica de microdiluição em caldo. <strong>Resultados: </strong>O óleo essencial apresentou como constituintes principais tim

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VALÉRIO, VANESSA IMACULADA DOS REIS, PEDRO HENRIQUE CARDOSO, LUIZ MENINI NETO, and FÁTIMA REGINA GONÇALVES SALIMENA. "Taxonomic and nomenclatural notes on Lantana and Lippia (Verbenaceae)." Phytotaxa 478, no. 2 (2021): 281–86. http://dx.doi.org/10.11646/phytotaxa.478.2.10.

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Lantana and Lippia are two large and taxonomically complicated genera of Verbenaceae. During studies of these genera for the “Flora do Brasil 2020” project some taxonomic problems were identified. Here, we propose the reestablishment of the species Lippia subracemosa, nine new synonyms and three lectotypes for Lippia jangadensis, Lippia thymoides, and Lippia vernonioides, the last one also with the designation of an epitype.

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Nascimento, Lidiane Diniz do, Sebastião Gomes Silva, Márcia Moraes Cascaes, et al. "Drying Effects on Chemical Composition and Antioxidant Activity of Lippia thymoides Essential Oil, a Natural Source of Thymol." Molecules 26, no. 9 (2021): 2621. http://dx.doi.org/10.3390/molecules26092621.

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Leaves of Lippia thymoides (Verbenaceae) were dried in an oven at 40, 50 and 60 °C and the kinetic of drying and the influence of the drying process on the chemical composition, yield, and DPPH radical scavenging activity of the obtained essential oils were evaluated. The composition of the essential oils was determined with gas chromatography-mass spectrometry and gas chromatography-flame ionization detection analyses. The influence of drying on the chemical composition of the essential oils of L. thymoides was evaluated by multivariate analysis, and their antioxidant activity was investigate

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Cruz, Jorddy Neves, Sebastião Gomes Silva, Daniel Santiago Pereira, et al. "In Silico Evaluation of the Antimicrobial Activity of Thymol—Major Compounds in the Essential Oil of Lippia thymoides Mart. & Schauer (Verbenaceae)." Molecules 27, no. 15 (2022): 4768. http://dx.doi.org/10.3390/molecules27154768.

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In this paper, we evaluated the drug-receptor interactions responsible for the antimicrobial activity of thymol, the major compound present in the essential oil (EO) of Lippia thymoides (L. thymoides) Mart. & Schauer (Verbenaceae). It was previously reported that this EO exhibits antimicrobial activity against Candida albicans (C. albicans), Staphylococcus aureus (S. aureus), and Escherichia coli (E. coli). Therefore, we used molecular docking, molecular dynamics simulations, and free energy calculations to investigate the interaction of thymol with pharmacological receptors of interest to

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5

Resque Beckmann Carvalho, Tabata, Erich Brito Tanaka, Amujacy Tavares Vilhena, et al. "Chemical composition, antimicrobial and antifungal activity of Lippia Thymoide essential oil in oral pathogens." Brazilian Journal of Oral Sciences 20 (February 10, 2021): e210219. http://dx.doi.org/10.20396/bjos.v20i00.8660219.

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Aim: This study evaluated the chemical composition of Lippia thymoides (Lt) essential oil and its antimicrobial activity against fungal strains of Candida albicans (Ca) and Gram-negative bacteria Prevotella intermedia (Pi) and Fusobacterium nucleatum (Fn). Methods: Lt essential oil was obtained by hydrodistillation apparatus with a modified Clevenger extension. The chemical analysis was analyzed by gas phase chromatography and mass spectrometry on Shimadzu QP 2010 plus. Sample sensitivity evaluation was performed by ABHb-inoculum and culture plates were developed with triphenyltetrazolium chlo

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Santos, Daiane Rodrigues, Lenaldo Muniz Oliveira, Angelica Maria Lucchese, Alexandre De Freitas Espeleta, Jucelho Dantas Da Cruz, and Maurício Santana Lordelo. "Insecticidal activity of essential oils of species from the genus Lippia against Nasutitermes corniger (Motschulsky) (Isoptera: Termitidae)." Sociobiology 67, no. 2 (2020): 292. http://dx.doi.org/10.13102/sociobiology.v67i2.4992.

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Lippia is one of the main genera in the family Verbenaceae, with 200 species described. Despite its richness in bioactive molecules, with several scientifically proven applications, there is little information on the insecticidal potential of its species. This study aimed to assess the insecticidal potential of essential oils from the species Lippia thymoides (Martius & Schauer); Lippia lasiocalycina (Schauer) and Lippia insignis (Moldenk) against Nasutitermes corniger (Motschulsky) (Isoptera-Termitidae). Insecticidal activity was evaluated by exposure to a contaminated surface, whereby pl

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Bispo, Luma dos Passos, Lenaldo Muniz de Oliveira, Marilza Neves do Nascimento, and Carlos Alberto da Silva Ledo. "Effect of indolebutyric acid and cutting type on vegetative propagation of three Lippia species." Ciência Rural 46, no. 8 (2016): 1364–67. http://dx.doi.org/10.1590/0103-8478cr20151029.

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ABSTRACT: The objective of this study was to evaluate the effect of different types of cuttings and indolebutyric acid (IBA) concentration on the vegetative propagation of Lippia insignis , L. lasiocalycina , and L. thymoides . The experiment was conducted in a 2×5 factorial table, by using 2 types of cuttings (apical and medial) and 5 IBA concentrations (0, 250, 500, 750, and 1000mg·L-1) in a Completely Randomized Design (CRD), with 4 replications and 10 cuttings per plot. For the propagation of L. insignis , apical cuttings are the most suitable, whereas for L. thymoides and L. lasiocalycina

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Jaimes Duarte, Linda Roxana, Sara Emilia Giraldo Quintero, Jesús Fredy Hoyos Argote, and María Consuelo Bernal Lizarazú. "Medicinal plants of the Verbenaceae family active against yeast fungi: Systematic review and perspectives 2015-2022." Revista Colombiana de Ciencias Químico-Farmacéuticas 53, no. 2 (2024): 306–35. https://doi.org/10.15446/rcciquifa.v53n2.114423.

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Introduction: Opportunistic fungal infections have increased in recent decades, requiring the search for therapeutic alternatives, also considering the appearance of new species and the increase in resistance to antifungals. Objective: This study describes plants of the Verbenaceae family with therapeutic potential against yeast fungi. Methodology: A systematic review was carried from 2015 to 2020, using different databases, applying inclusion and exclusion criteria, also exploring recent perspectives to 2022. Results and discussion: 5 genera and 14 species with potential antifungal activity w

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Trindade, Soraya Castro, Jurandi Nery Pereira-Filho, Laerte Oliveira Barreto Neto, et al. "Atividade antimicrobiana dos extratos metanólicos de diferentes espécies do gênero Lippia." Research, Society and Development 10, no. 9 (2021): e22610918051. http://dx.doi.org/10.33448/rsd-v10i9.18051.

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As espécies do gênero Lippia (Verbenaceae) possuem diversas moléculas bioativas, oriundas do seu metabolismo secundário, que apresentam atividade antimicrobiana, analgésica, antifúngica e imunomoduladora. Este estudo teve como objetivo avaliar a atividade antimicrobiana in vitro do extrato metanólico das folhas de L. alnifolia, L. origanoides, L. insignis e L. thymoides frente a microrganismos de importância clínica. Foi realizada uma triagem fitoquímica dos extratos das plantas e a avaliação da atividade antimicrobiana pelo método de difusão em disco, além da determinação da concentração inib

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Lima, Carla Teixeira de, and Flávio França. "Lamiaceae e Verbenaceae em Inselbergues do Semi-árido da Bahia, Brasil." SITIENTIBUS série Ciências Biológicas 8, no. 2 (2008): 220–29. http://dx.doi.org/10.13102/scb8093.

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É apresentado o levantamento das espécies de Lamiaceae e Verbenaceae ocorrentes nos inselbergues do semi-árido baiano. O material estudado foi coletado nas áreas de estudos, sendo também utilizados materiais de herbário coletados em outros locais. Foram registradas 15 espécies, Aegiphila integrifolia, Hyptis fruticosa, H. pectinata e Marsypianthes chamaedrys (Lamiaceae); Lantana camara, L. canescens, L. fucata, L. sp., Lippia elliptica, L. microphylla, L. pohliana, L. thymoides, Priva bahiensis, Stachytarpheta angustifólia e S. bicolor (Verbenaceae).

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Jiménez Pérez, V. M., B. M. Muñoz Flores, E. Hernández Fernández, D. Celis, J. Treviño Carreón, and S. Moreno. "Recent advances in oregano (Lippia graveolens and Poliomintha Iongiflora): Extraction methods component determination, and their potential applications." Quimica Hoy 4, no. 3 (2014): 15. http://dx.doi.org/10.29105/qh4.3-217.

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The work presented here describes the most significant advances in concerning the chemistry of oregano (Lippia graveolens and Poliomintha longiflora). We present new, green methods for essential oil extraction as well as the potential medicinal properties of said oil. This review also focuses on the determination of its main components, such as carvacrol and thymol. We describe their syntesis, reactivity, and potential applications of both compounds in various areas.

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Manjarrez-Quintero, Juan Pablo, Octavio Valdez-Baro, Raymundo Saúl García-Estrada, et al. "Optimized Ultrasonic Extraction of Essential Oil from the Biomass of Lippia graveolens Kunth Using Deep Eutectic Solvents and Their Effect on Colletotrichum asianum." Processes 12, no. 7 (2024): 1525. http://dx.doi.org/10.3390/pr12071525.

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Essential oils are emerging as alternatives to conventional pest control chemicals. Lippia graveolens Kunth (Mexican oregano) is a source of essential oils and during conventional extraction, the biomass generated is discarded as waste; however, reports show that this biomass is still a rich source of essential oils. Conventional essential oil extraction causes contamination and utilizes toxic solvents. Deep eutectic solvents (DESs) offer low toxicity, biodegradability, high selectivity, and yields comparable to organic solvents. This study obtained essential oil from Lippia graveolens biomass

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Rojas, Janne, Antonio Morales, Sara Pasquale, et al. "Comparative Study of the Chemical Composition of the Essential Oil of Lippia oreganoides Collected in Two Different Seasons in Venezuela." Natural Product Communications 1, no. 3 (2006): 1934578X0600100. http://dx.doi.org/10.1177/1934578x0600100306.

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The essential oils from the leaves of Lippia oreganoides collected in June 2003 (rainy season) and February 2004 (dry season) were analyzed by GC/MS. Thymol (61.9% and 44.7%, respectively) and carvacrol (7.9% and 16.8%, respectively) proved to be the major constituents of both collections. Linalool (0.4%) was present only in the collection made in June 2003, while carvacryl acetate (0.6% and caryophyllene oxide (1.6%) were only detected in the February 2004 collection.

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Albuquerque, C. C., T. R. Camara, A. E. G. Sant'ana, C. Ulisses, L. Willadino, and C. Marcelino Júnior. "Effects of the essential oil of Lippia gracilis Schauer on caulinary shoots of heliconia cultivated in vitro." Revista Brasileira de Plantas Medicinais 14, no. 1 (2012): 26–33. http://dx.doi.org/10.1590/s1516-05722012000100005.

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The effects of thymol and carvacrol and the essential oil of Lippia gracilis on caulinary shoots of heliconia were evaluated. After disinfection, the shoots were inoculated into MS medium and subjected to the treatments with 420 µL L-1 of essential oil (EO) of L. gracilis; 420 µL L-1 of thymol; 420 µL L-1 of carvacrol; 210 µL L-1 of thymol and 210 µL L-1 of carvacrol. The control treatment consisted of the MS medium without any phytoregulators. The main components of EO from L. gracilis are carvacrol, ρ-cimene, and thymol. Seven days after the initiation of the experiments, 36.3% of the contro

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Melo, Juliana Oliveira de, Arie Fitzgerald Blank, Rogéria de Souza Nunes, et al. "Essential oils of Lippia gracilis and Lippia sidoides chemotypes and their major compounds carvacrol and thymol: nanoemulsions and antifungal activity against Lasiodiplodia theobromae." Research, Society and Development 11, no. 3 (2022): e36511326715. http://dx.doi.org/10.33448/rsd-v11i3.26715.

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The aim of this work was to evaluate the antifungal activity of essential oils (EOs) of Lippia gracilis and Lippia sidoides accessions, their major compounds and nanoemulsions. Nanoemulsions with 18% of EO or major compound were produced by spontaneous emulsification method. The EO of two L. gracilis accessions (LGRA-106 and LGRA-109) and two L. sidoides accessions (LSID-102 and LSID-104) were extracted by hydrodistillation and the major compounds thymol and carvacrol were purchased commercially. Antifungal activity was tested against Lasiodiplodia theobromae by calculating the percentage of i

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Rodrigo Marcelino Zacarias, de Andrade, de Paixão Santos Bernardina, Fernandes Silva Roberson Matteus, et al. "Antibacterial Screening of Lippia origanoides Essential Oil on Gram-negative Bacteria." Archives of Pharmacy and Pharmaceutical Sciences 8, no. 1 (2024): 024–28. http://dx.doi.org/10.29328/journal.apps.1001053.

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Essential oils (EO) are extracted from different plant species and can be present in different plant organs. Rosemary-pepper EO is composed of around 50% to 70% thymol, a phenolic compound proven to be active against fungi and bacteria. The active components present in these compounds can affect the vital functionality of bacterial cells, leading to protein denaturation and cell lysis. Therefore, the present study aims to evaluate in vitro the antibacterial potential of Lippia origanoides EO against gram-negative bacteria. This is an exploratory study, with a technical-experimental procedure,

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Ortega-Nieblas, Ma Magdalena, Ma Refugio Robles-Burgueño, Evelia Acedo-Félix, Alberto González-León, Adriana Morales-Trejo, and Luz Vázquez-Moreno. "CHEMICAL COMPOSITION AND ANTIMICROBIAL ACTIVITY OF OREGANO (Lippia palmeri S. WATS) ESSENTIAL OIL." Revista Fitotecnia Mexicana 34, no. 1 (2011): 11. http://dx.doi.org/10.35196/rfm.2011.1.11.

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The chemical composition and antimicrobial activity of Lippia palmeri S. Wats essential oil extracted from plants collected of two localities (Álamos and Puerto del Orégano) in the State of Sonora, México, was examined. Essential oils (EO) were obtained from oregano leaves by steam distillation, analyzed by gas chromatography coupled with a mass spectrometer, and their antimicrobial activity against human pathogens investigated by disc diffusion. Álamos and Puerto del Orégano essential oils (AEO and POEO) presented 50 and 60 constituents, respectively. The components were classified as monoter

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Oliveira, Ariana Reis Messias Fernandes de, Lenaldo Muniz de Oliveira, Joseane Silva Carneiro, Tânia Regina dos Santos Silva, and Larissa Correa do Bonfim Costa. "LEAF ANATOMY AND ESSENTIAL OIL PRODUCTION IN NATIVE SPECIES OF LIPPIA." BRAZILIAN JOURNAL OF AGRICULTURE - Revista de Agricultura 93, no. 3 (2019): 324. http://dx.doi.org/10.37856/bja.v93i3.3238.

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This work aimed to perform a comparative study of leaf anatomy, trichome frequency and essential oil production of some Lippia native species of the semi-arid region of Bahia, Brazil. Leaf samples were analyzed with light microscopy and scanning electron microscopy to describe the structure and to quantify the trichome frequency. Six types of glandular trichomes were identified: uni, bi and tetracellular, as well as three types of tectorial trichomes. L. bromleyana presents an ornamented epidermis and no tectorial trichomes on the abaxial surface. L. thymoides has glandular trichomes with irre

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Menezes, Pedro Modesto Nascimento, Henrique Ribeiro de Oliveira, Mariana Coelho Brito, et al. "Spasmolytic and antidiarrheal activities of Lippia thymoides (Verbenaceae) essential oil." Natural Product Research 33, no. 17 (2018): 2571–73. http://dx.doi.org/10.1080/14786419.2018.1457665.

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Zapata-Zapata, Carolina, Mauricio Rojas-López, Liliana T. García, et al. "Lippia origanoides Essential Oil or Thymol in Combination with Fluconazole Produces Damage to Cells and Reverses the Azole-Resistant Phenotype of a Candida tropicalis Strain." Journal of Fungi 9, no. 9 (2023): 888. http://dx.doi.org/10.3390/jof9090888.

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Candida tropicalis is one of the most pathogenic species within the genus. Increased antifungal resistance has been reported, which is in part due to the organism’s ability to form biofilms. In natural products derived from plants, such as essential oils (EOs) or their major components, there is significant potential to develop new antifungals or to both enhance the efficacy and reduce the toxicity of conventional antifungals. This study aimed to evaluate the effect of combining an EO of Lippia origanoides or thymol with fluconazole on an azole-resistant C. tropicalis strain. Synergism was obs

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Dias, Bruna Leticia, Talita Pereira de Souza Ferreira, Mateus Sunti Dalcin, et al. "Lippia sidoides Cham. Compounds Induce Biochemical Defense Mechanisms Against Curvularia lunata sp. in Maize Plants." J 8, no. 1 (2025): 7. https://doi.org/10.3390/j8010007.

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Corn (Zea mays L.) productivity is often compromised by phytosanitary challenges, with fungal disease like Curvularia leaf spot being particularly significant. While synthetic fungicides are commonly used, there is growing interest in exploring alternative compounds that are effective against pathogens, ensure food safety, and have low toxicity to non-target organisms. In this study, we examined the biochemical changes in corn plants treated with Lippia sidoides essential oil and its major compound, thymol. Both treatments serve as preventive measures for inoculated plants and induced resistan

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Almeida, Brígida Resende, Suzan Kelly Vilela Bertolucci, Alexandre Alves de Carvalho, Heitor Luiz Heiderich Roza, Felipe Campos Figueiredo, and José Eduardo Brasil Pereira Pinto. "Macronutrient Omission Changes Lippia gracilis Schauer, a Threatened Medicinal Plant, Growth and Volatile Chemical Composition." HortScience 53, no. 12 (2018): 1877–82. http://dx.doi.org/10.21273/hortsci13492-18.

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The effect of macronutrient omission on the growth and volatile chemical composition of Lippia gracilis was evaluated. The “minus one element” technique was employed by using a complete (Hoagland and Arnon, 1950) nutrient solution and solutions with macronutrient omission for N, P, K, Ca, Mg, and S. Macronutrient deficiency significantly influenced L. gracilis growth and volatile chemical composition. Leaf dry weight decreased in order of importance of the macronutrients as follows: Ca = K = N > P > Mg > S. The amount and composition of volatile compounds varied according to macronutr

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Torres, Liz Maria, Alexander Pérez-Cordero, Angélica Torregroza-Espinosa, and Deimer Vitola-Romero. "Chemical comparison of the essential oils of Lippia Origanoides in two agroclimatic zones of the Colombian Caribbean coast." DYNA 89, no. 220 (2022): 172–77. http://dx.doi.org/10.15446/dyna.v89n220.95739.

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The objective of this research is to compare the chemical profiles of the essential oils of Lippia origanoides leaves collected in Santa Marta and Sincelejo at different hours. The leaves were harvested at 6:00 a.m., 12:00 p.m, and 6:00 p.m, the essential oils were extracted by hydrodistillation assisted by microwave radiation and the chemical profiles were determined by gas chromatography coupled to mass spectrometry. The results showed Thymol as the major metabolite in all samples, however, Sincelejo presented the highest percentages of Thymol with 68.02% at 6:00 a.m., while in Santa Marta a

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de Souza, Luciana Mendes, Francine Souza Alves da Fonseca, Julio Cesar Rodrigues Lopes Silva, and Ernane Ronie Martins. "Seasonal variation of essential oil of germplasm of Lippia origanoides Kunth. (Verbenaceae)." Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas 21, no. 6 (2022): 716–24. http://dx.doi.org/10.37360/blacpma.22.21.6.43.

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The biological activities attributed to Lippia origanoidesKunth. vary according to the chemical composition of its essential oil, which can be related to weather factors. The aim of this research was the seasonal study of the essential oil chemical composition taken from L. origanoidesaccessions maintained in germplasm bank in vivo. The essential oil was extracted by hydrodistillation in Clevenger apparatus and identification of the components was done by GC-MS. We have identified 15 compounds of which carvacrol, p-cymene, thymol and methyl-ether-thymol were majority throughout the year for mo

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Sampaio, Renata de Souza, Giuliana Amanda de Oliveira, Luiz Henrique César Vasconcelos, et al. "Vasorelaxation in rat pulmonary artery induced by the monoterpene thymol: evaluation of the endothelium derived relaxant factors dependence." Research, Society and Development 10, no. 4 (2021): e29010413971. http://dx.doi.org/10.33448/rsd-v10i4.13971.

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Thymol and carvacrol are the main compounds found in Lippia mycrophylla essential oil (LM-OE) and have presented some spasmolytic effects. This work was designed to explore a possible vasorelaxant effect of LM-OE and its major monoterpenes constituents on rat pulmonary artery. For that, the organ was in vitro stimulated with phenylephrine (Phe) 3 mM and over the tonic contraction the relaxant effect of LM-OE, carvacrol and thymol was observed in both intact and denuded-endothelium. Moreover, atropine, L-NAME, indomethacin, 2,3-O-isopropylidene adenosine, H-89 and Y-27632 were incubated before

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Felix, Stênio Freitas, Alzeir Machado Rodrigues, Ana Livya Moreira Rodrigues, et al. "Chemical Composition, Larvicidal Activity, and Enzyme Inhibition of the Essential Oil of Lippia grata Schauer from the Caatinga Biome against Dengue Vectors." Pharmaceuticals 14, no. 3 (2021): 250. http://dx.doi.org/10.3390/ph14030250.

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Insect resistance and environmental pollution are among the drawbacks of continuous use of synthetic insecticides against the vectors of dengue, Aedesaegypti and Aedes albopictus. The objective of this study was to analyze the composition of the essential oil of Lippia grata Schauer collected from plants, in three periods of the year, to compare the larvicidal activity and enzymatic inhibition of the dengue vectors. The oilsanalyzed by gas chromatography coupled to mass spectrometry (GC-MS), presented thymol and 1,8-cineole, as the main constituents, in all three periods. This composition was

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Silva-Trujillo, Lina, Elizabeth Quintero-Rueda, Elena E. Stashenko, Sergio Conde-Ocazionez, Paola Rondón-Villarreal, and Raquel E. Ocazionez. "Essential Oils from Colombian Plants: Antiviral Potential against Dengue Virus Based on Chemical Composition, In Vitro and In Silico Analyses." Molecules 27, no. 20 (2022): 6844. http://dx.doi.org/10.3390/molecules27206844.

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Currently, there are no therapies to prevent severe dengue disease. Essential oils (EOs) can serve as primary sources for research and the discovery of phytomedicines for alternative therapy. Fourteen EOs samples were obtained by distillation from six plants used in Colombian folk medicine. GC/MS analysis identified 125 terpenes. Cytopathic effect (CPE) reduction assays revealed differences in antiviral activity. EOs of Lippia alba, citral chemotype and carvone-rich fraction; Lippia origanoides, phellandrene chemotype; and Turnera diffusa, exhibited strong antiviral activity (IC50: 29 to 82 µg

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Lima, Rafaela Karin, Maria das Graças Cardoso, Jair Campos Moraes, Stephan Malfitano Carvalho, Vanessa Gregório Rodrigues, and Luiz Gustavo Lima Guimarães. "Chemical composition and fumigant effect of essentialoil of Lippia sidoides Cham. and monoterpenes against Tenebrio molitor (L.) (coleoptera: tenebrionidae)." Ciência e Agrotecnologia 35, no. 4 (2011): 664–71. http://dx.doi.org/10.1590/s1413-70542011000400004.

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The chemical composition of Lippia sidoides essential oils obtained by hydrodistillation was characterized and quantified by GC/MS and their insecticidal activity by fumigation test was assayed against Tenebrio molitor. Moreover, the toxicity of monoterpenes carvacrol, 1,8-cineol and thymol were also evaluated when applied alone or in binary (1:1) or tertiary (1:1:1) mixture. The essential oil of L. sidoides has as major constituents carvacrol (31.68%), ρ-cymene (19.58%), 1,8-cineole (9.26%) and ϒ-terpinene (9.21%), from a 21 compounds identified, being 92.53% of total. Both compounds have ins

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Guimarães, Luiz Gustavo de L., Maria Laura M. da Silva, Paula Campos J. Reis, Maria Tereza R. Costa, and Lívia L. Alves. "General Characteristics, Phytochemistry and Pharmacognosy of Lippia sidoides." Natural Product Communications 10, no. 11 (2015): 1934578X1501001. http://dx.doi.org/10.1177/1934578x1501001116.

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Lippia sidoides Cham. is a plant that belongs to the family Verbenaceae and is commonly known as “alecrim-pimenta”. It was first found in northeastern Brazil, where it is extensively used in traditional medicine. Many studies have been made with the essential oil of L. sidoides, which has a high content of the isomeric compounds thymol and carvacrol. L. sidoides extracts, and particularly the essential oil extracted from its aerial parts, have shown many biological activities such as antifungal, antibacterial, and insecticidal. Given the great biological potentialities of L. sidoides and the a

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Stashenko, Elena, Carlos Ruiz, Amner Muñoz, Martha Castañeda, and Jairo Martínez. "Composition and Antioxidant Activity of Essential Oils of Lippia Origanoides H.B.K. grown in Colombia." Natural Product Communications 3, no. 4 (2008): 1934578X0800300. http://dx.doi.org/10.1177/1934578x0800300417.

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Microwave-assisted hydrodistillation, simultaneous distillation-solvent extraction, and supercritical fluid extraction, were used to isolate secondary metabolites from two Lippia origanoides chemotypes growing wild in Colombia. Compound identification was based on chromatographic and spectroscopic criteria. The main components identified in the essential oil of one chemotype were carvacrol (44.4 – 51.8%) and p-cymene (8.8 – 10.1%). Those of the other chemotype were p-cymene (11.3 – 15.7%) and 1,8-cineole (6.8 – 10.9%). The last one constitutes a new chemotype, characterized by its low thymol a

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Silva, Sebastião Gomes, Mozaniel Santana de Oliveira, Jorddy Neves Cruz, et al. "Supercritical CO2 extraction to obtain Lippia thymoides Mart. & Schauer (Verbenaceae) essential oil rich in thymol and evaluation of its antimicrobial activity." Journal of Supercritical Fluids 168 (February 2021): 105064. http://dx.doi.org/10.1016/j.supflu.2020.105064.

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Tapia-Rodriguez, Melvin Roberto, Ernesto Uriel Cantu-Soto, Francisco Javier Vazquez-Armenta, Ariadna Thalia Bernal-Mercado, and Jesus Fernando Ayala-Zavala. "Inhibition of Acinetobacter baumannii Biofilm Formation by Terpenes from Oregano (Lippia graveolens) Essential Oil." Antibiotics 12, no. 10 (2023): 1539. http://dx.doi.org/10.3390/antibiotics12101539.

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Acinetobacter baumannii is a nosocomial pathogen known for its ability to form biofilms, leading to persistent infections and antibiotic resistance. The limited effective antibiotics have encouraged the development of innovative strategies such as using essential oils and their constituents. This study evaluated the efficacy of oregano (Lippia graveolens) essential oil (OEO) and its terpene compounds, carvacrol and thymol, in inhibiting A. baumannii biofilms. These treatments showed a minimum inhibitory concentration of 0.6, 0.3, and 2.5 mg/mL and a minimum bactericidal concentration of 1.2, 0

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Baier Krepsky, Patrícia, Dilaine Suellen Caires Neves, and Gabriela Nunes Santana. "Variação intraespecífica na composição e teor do óleo essencial de Lippia thymoides." Revista Fitos 15, no. 2 (2021): 192–203. http://dx.doi.org/10.32712/2446-4775.2021.1062.

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Lippia thymoides é uma planta aromática e medicinal nativa na Caatinga e Cerrado brasileiros. Pesquisas foram realizadas nas áreas de farmacologia e fitoquímica, no entanto, o conhecimento científico sobre a variação química é inceptivo. Portanto, esta pesquisa teve como objetivo avaliar possíveis fatores que interferem no teor e composição química do óleo essencial de folhas e flores. Para determinação do teor de óleo essencial foi empregado aparelho de Clevenger. O óleo essencial obtido foi avaliado por cromatografia gasosa acoplada a espectrômetro de massas. As variáveis foram: diferentes i

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Chacón-Vargas, Karla Fabiola, Luvia Enid Sánchez-Torres, Mónica L. Chávez-González, Jaime R. Adame-Gallegos, and Guadalupe Virginia Nevárez-Moorillón. "Mexican Oregano (Lippia berlandieri Schauer and Poliomintha longiflora Gray) Essential Oils Induce Cell Death by Apoptosis in Leishmania (Leishmania) mexicana Promastigotes." Molecules 27, no. 16 (2022): 5183. http://dx.doi.org/10.3390/molecules27165183.

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Leishmaniasis is a neglected vector-borne disease; there are different manifestations of the diseases and species involved, and cutaneous leishmaniasis caused by Leishmania (L.) mexicana is the most prevalent in Mexico. Currently, the drugs available for the treatment of leishmaniasis are toxic, expensive, and often ineffective; therefore, it is imperative to carry out research and development of new therapeutic alternatives, with natural products being an attractive option. In particular, oregano is a plant with worldwide distribution; in Mexico, two species: Lippia berlandieri Schauer and Po

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García-Pérez, Josué, Juan Pérez-Sabino, Susana Mendoza-Elvira, Antonio Jorge Ribeiro da Silva, and Juan Ulloa-Rojas. "Antimicrobial Activity of Diverse Chemotypes of Lippia graveolens Against Aeromonas hydrophila Isolated from Oreochromis niloticus." Uniciencia 38, no. 1 (2024): 1–15. http://dx.doi.org/10.15359/ru.38-1.30.

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[Objective] This study aimed to evaluate the antimicrobial efficacy of essential oil (EO) from diverse chemotypes of Lippia graveolens against oxytetracycline-resistant Aeromonas hydrophila, which primarily affects the tilapia aquaculture (O. niloticus) in Guatemala. [Methodology] L. graveolens were collected in three departments in Guatemala. The EO was obtained by hydrodistillation and characterized using gas chromatography and mass spectrometry (GC/MS). Subsequently, an antimicrobial assay was conducted using disk and dilution susceptibility tests and evaluation of synergistic interactions

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Cáceres, Marlon, William Hidalgo, Elena Stashenko, Rodrigo Torres, and Claudia Ortiz. "Essential Oils of Aromatic Plants with Antibacterial, Anti-Biofilm and Anti-Quorum Sensing Activities against Pathogenic Bacteria." Antibiotics 9, no. 4 (2020): 147. http://dx.doi.org/10.3390/antibiotics9040147.

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Both the ability of bacteria to form biofilms and communicate through quorum sensing allows them to develop different survival or virulence traits that lead to increased bacterial resistance against conventional antibiotic therapy. Here, seventeen essential oils (EOs) were investigated for the antimicrobial, antibiofilm, and anti-quorum sensing activities on Escherichia. coli O157:H7, Escherichia coli O33, and Staphylococcus epidermidis ATCC 12228. All essential oils were isolated from plant material by using hydrodistillation and analyzed by GC-MS. The antimicrobial activity was performed by

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González-Güereca, Martha Celina. "Repellency of Oregano (Lippia graveolens HBK): Against Periplaneta americana (Blattodea: Blattidae) from Durango, Mexico in Vitro." Environmental Sciences and Ecology: Current Research (ESECR 4, no. 3 (2023): 1–4. http://dx.doi.org/10.54026/esecr/1095.

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Background: The sewer cockroach is one of the important pests in the health sector due to the microorganisms they carry in their bodies, contaminate food, and mainly affect the respiratory tract. Most chemical insecticides applied to control this pest affect people’s health and in addition to the fact that cockroaches have already become resistant to many of these products. An environmentally friendly alternative in pest control is the use of aromatic plants. The repellency of residual oregano hydrosols from three municipalities of Durango was evaluated in this research. The control groups dra

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Xavier, Aline L., João Carlos L. R. Pita, Monalisa T. Brito, et al. "Chemical composition, antitumor activity, and toxicity of essential oil from the leaves of Lippia microphylla." Zeitschrift für Naturforschung C 70, no. 5-6 (2015): 129–37. http://dx.doi.org/10.1515/znc-2014-4138.

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Abstract The chemical composition, antitumor activity and toxicity of the essential oil from Lippia microphylla leaves (OEL) were investigated. The major constituents were thymol (46.5%), carvacrol (31.7%), p-cymene (9%), and γ-terpinene (2.9%). To evaluate the toxicity of OEL in non-tumor cells, the hemolytic assay with Swiss mice erythrocytes was performed. The concentration producing 50% hemolysis (HC50) was 300 μg/mL. Sarcoma 180 tumor growth was inhibited in vivo 38% at 50 mg/kg, and 60% at 100 mg/kg, whereas 5-FU at 50 mg/kg caused 86% inhibition. OEL displays moderate gastrointestinal a

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Canché-Collí, César, Humberto Estrella-Maldonado, Luis A. Medina-Medina, et al. "Effect of yeast and essential oil-enriched diets on critical determinants of health and immune function in Africanized Apis mellifera." PeerJ 9 (October 15, 2021): e12164. http://dx.doi.org/10.7717/peerj.12164.

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Nutrition is vital for health and immune function in honey bees (Apis mellifera). The effect of diets enriched with bee-associated yeasts and essential oils of Mexican oregano (Lippia graveolens) was tested on survival, food intake, accumulated fat body tissue, and gene expression of vitellogenin (Vg), prophenoloxidase (proPO) and glucose oxidase (GOx) in newly emerged worker bees. The enriched diets were provided to bees under the premise that supplementation with yeasts or essential oils can enhance health variables and the expression of genes related to immune function in worker bees. Based

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Zapata-Zapata, Carolina, Manuela Loaiza-Oliva, María C. Martínez-Pabón, Elena E. Stashenko, and Ana C. Mesa-Arango. "In Vitro Activity of Essential Oils Distilled from Colombian Plants against Candidaauris and Other Candida Species with Different Antifungal Susceptibility Profiles." Molecules 27, no. 20 (2022): 6837. http://dx.doi.org/10.3390/molecules27206837.

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Multi-drug resistant species such as Candida auris are a global health threat. This scenario has highlighted the need to search for antifungal alternatives. Essential oils (EOs), or some of their major compounds, could be a source of new antifungal molecules. The aim of this study was to evaluate the in vitro activity of EOs and some terpenes against C. auris and other Candida spp. The eleven EOs evaluated were obtained by hydro-distillation from different Colombian plants and the terpenes were purchased. EO chemical compositions were obtained by gas chromatography/mass spectrometry (GC/MS). A

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Andrade, Viviane A., Anna C. Almeida, Dayane S. Souza, et al. "Antimicrobial activity and acute and chronic toxicity of the essential oil of Lippia origanoides." Pesquisa Veterinária Brasileira 34, no. 12 (2014): 1153–61. http://dx.doi.org/10.1590/s0100-736x2014001200002.

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Currently, there is a growing interest in medicinal plants, because of an increased demand for alternate therapies. In this study, the antimicrobial activity and toxicity of the essential oil of Lippia origanoides (L. origanoides) were investigated. The essential oil of L. origanoides was extracted by steam-dragging distillation and its constituents were identified by chromatography coupled with mass spectrometry. Among the 15 compounds identified, the most abundant were carvacrol (29.00%), o-cymene (25.57%), and thymol methyl ether (11.50%). The essential oil was studied in antimicrobial assa

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Baldim, Iara, Andressa M. Oliveira, Eliana B. Souto, and Wanderley P. Oliveira. "Cyclodextrins-in-Liposomes: A Promising Delivery System for Lippia sidoides and Syzygium aromaticum Essential Oils." Life 12, no. 1 (2022): 95. http://dx.doi.org/10.3390/life12010095.

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Biological activity of essential oils (EOs) has been extensively reported; however, their low aqueous solubility, high photosensitivity, and volatility compromise a broad industrial use of these compounds. To overcome these limitations, we proposed a nanoencapsulation approach to protect EOs, that aims to increase their stability and modulate their release profile. In this study, drug-in-cyclodextrin-in-liposomes encapsulating two essential oils (Lippia sidoides and Syzygium aromaticum) and their respective major compounds (thymol and eugenol) were produced by ethanol injection and freeze-drie

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Hernández-Hernández, Elvia, Carlos Regalado-González, Pedro Vázquez-Landaverde, Isabel Guerrero-Legarreta, and Blanca E. García-Almendárez. "Microencapsulation, Chemical Characterization, and Antimicrobial Activity of Mexican (Lippia graveolensH.B.K.) and European (Origanum vulgareL.) Oregano Essential Oils." Scientific World Journal 2014 (2014): 1–12. http://dx.doi.org/10.1155/2014/641814.

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The effect of solvent polarity (methanol and pentane) on the chemical composition of hydrodistilled essential oils (EO’s) ofLippia graveolensH.B.K. (MXO) andOriganum vulgareL. (EUO) was studied by GC-MS. Composition of modified starch microencapsulated EO’s was conducted by headspace-solid-phase microextraction (HS-SPME). The antimicrobial activity of free and microencapsulated EO’s was evaluated. They were tested againstSalmonellasp.,Brochothrix thermosphacta,Pseudomonas fragi, Lactobacillus plantarum, andMicrococcus luteus. Thymol and carvacrol were among the main components of EO’s and thei

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Delgado Ospina, Johannes, Carlos David Grande Tovar, Juan Carlos Menjívar Flores, and Manuel Salvador Sánchez Orozco. "RELATIONSHIP BETWEEN REFRACTIVE INDEX AND THYMOL CONCENTRATION IN ESSENTIAL OILS OF Lippia origanoides Kunth." Chilean journal of agricultural & animal sciences 32, no. 2 (2016): 127–33. http://dx.doi.org/10.4067/s0719-38902016000200006.

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de A. Matos, Francisco José, Maria Iracema L. Machado, Afrânio A. Craveiro, José Wilson Alencar, and Maria Goretti de V. Silva. "Medicinal Plants of Northeast Brazil Containing Thymol and Carvacrol -Lippia sidoidesCham. andL. gracillisH.B.K. (Verbenaceae)." Journal of Essential Oil Research 11, no. 6 (1999): 666–68. http://dx.doi.org/10.1080/10412905.1999.9711990.

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Júnior, Antônio Quaresma da Silva, Gabriela dos Santos Rodrigues, Adenilson de Sousa Barroso, et al. "Essential Oil of Lippia origanoides Kunth: Nanoformulation, Anticholinesterase Activity, and Molecular Docking." Molecules 30, no. 7 (2025): 1554. https://doi.org/10.3390/molecules30071554.

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This study investigates the therapeutic potential of Lippia origanoides essential oil (LOEO) in neurological and pharmaceutical applications. The chemical composition of LOEO was analyzed using gas chromatography–mass spectrometry (GC-MS), revealing major constituents, such as carvacrol, thymol, and γ-gurjunene, known for their antioxidant and antimicrobial properties. LOEO demonstrated significant acetylcholinesterase (AChE)-inhibitory activity, particularly in a nanoformulation that enhances bioavailability and stability. Additionally, the major constituent carvacrol, when tested in isolatio

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Botelho, M. A., N. A. P. Nogueira, G. M. Bastos, et al. "Antimicrobial activity of the essential oil from Lippia sidoides, carvacrol and thymol against oral pathogens." Brazilian Journal of Medical and Biological Research 40, no. 3 (2007): 349–56. http://dx.doi.org/10.1590/s0100-879x2007000300010.

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Santos Lazzarini, Luiz Eduardo, Suzan Kelly Vilela Bertolucci, Alexandre Alves de Carvalho, et al. "Growth regulators affect the dry weight production, carvacrol and thymol content of Lippia gracilis Schauer." Industrial Crops and Products 129 (March 2019): 35–44. http://dx.doi.org/10.1016/j.indcrop.2018.11.070.

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Veras, Helenicy N. H., Fabíola F. G. Rodrigues, Aracélio V. Colares, et al. "Synergistic antibiotic activity of volatile compounds from the essential oil of Lippia sidoides and thymol." Fitoterapia 83, no. 3 (2012): 508–12. http://dx.doi.org/10.1016/j.fitote.2011.12.024.

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Teixeira, Maria L., Silvana Marcussi, Danubia A. de C.S. Rezende, Maisa L. Magalhães, David L. Nelson, and Maria das G. Cardoso. "Essential Oil from Lippia origanoides (Verbenaceae): Haemostasis and Enzymes Activity Alterations." Medicinal Chemistry 15, no. 2 (2019): 207–14. http://dx.doi.org/10.2174/1573406414666180829150515.

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Background: The search for natural inhibitors of snake venom toxins is essential to supplement or even replace the serum therapy. The aim of this work was to evaluate the pharmacological properties of essential oil from Lippia origanoides Kunth. (Verbenaceae). Methods: The oil was extracted by hydrodistillation and the constituents were identified and quantified by GC-MS and GC-FID. The essential oil from L. origanoides was evaluated in hemolysis tests, on the activities of phospholipases A2 and serine proteases and in coagulation and thrombolysis induced by different snake venoms. Results: Th

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