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Dissertations / Theses on the topic 'Liquid biopsy'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Abbou, Samuel. "Liquid Biopsy in Pediatric Sarcoma." Thesis, université Paris-Saclay, 2022. http://www.theses.fr/2022UPASL037.

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Résumé : Les biopsies liquides ouvrent de nouveaux champs d'applications dans la prise en charge des patients au diagnostic, au cours de leur suivi et également en recherche translationnelle. Ces dernières années, de nombreux efforts ont été consacrés au développement de l'ADN tumoral circulant (ADNct) et des cellules tumorales circulantes (CTC). Il y a malgré tout de nombreux terrains encore en friches dans les cancers de l'enfant, et parmi eux dans les sarcomes pédiatriques.Nous avons souhaité explorer dans ce travail différents aspects des applications cliniques éventuelles et d'utilisation

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2

BARBARESCO, FEDERICA. "Microfluidic devices: application for liquid biopsy." Doctoral thesis, Politecnico di Torino, 2021. http://hdl.handle.net/11583/2903504.

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GIORDANI, Elena. "Liquid Biopsy in Real Life Oncology." Doctoral thesis, Università degli studi di Ferrara, 2022. http://hdl.handle.net/11392/2481324.

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Secondo il report “I numeri del cancro in Italia 2020” dell’Associazione italiana registri tumori (AIRTUM) e l’Associazione italiana di oncologia medica (AIOM), il tumore al seno resta la neoplasia più frequente in Italia e la prima causa di morte per tumore nelle donne. Il sottotipo HER2+ rappresenta il 30% dei tumori al seno ed è associato ad una prognosi infausta, sebbene l’utilizzo di terapie mirate abbia reso questo sottotipo curabile come altri biologicamente meno aggressivi. Tuttavia, i pazienti in stadio avanzato, trattati con terapie antiHER2, spesso sviluppano resistenza al trattamen

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4

Palmieri, Maria. "CfDNA-NGS Liquid Biopsy for solid cancers and vascular malformations." Doctoral thesis, Università di Siena, 2020. http://hdl.handle.net/11365/1120548.

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The liquid biopsy is a new emerging and repeatable low risky approach able to detect drive mutations that characterize the tumor, to monitor cancer evolution over time, and to overcome the standard tissue biopsy limits. The biomarker par excellence is the circulating cell-free DNA (cfDNA) that was the principal leading actor of this study. The scope of this study was to perform different liquid biopsy analysis both in metastatic cancer and in vascular malformations patients to detect, from a precision medicine perspective, the sniper clone responsible for the tumor evolution or the vascular ma

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Soda, Narshone. "Advanced Liquid Biopsy Technologies for Circulating Cancer Biomarker Detection." Thesis, Griffith University, 2021. http://hdl.handle.net/10072/406071.

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Epithelial ovarian cancer is one of the most prevalent gynaecological cancers in women and is often diagnosed in the late stage due to the mild symptoms. Currently, ovarian cancer screening is reliant on the prevailing usage of blood based CA125 protein biomarker and transvaginal ultrasound which can detect ovarian cancer in the preclinical phase in a substantial portion of cases. However, there are also other elements that can result in elevated CA125 levels such as menstruation, endometriosis or ovarian cysts. As such, the lack of accurate disease risk classification during ovarian cancer sc

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6

Yap, Soo Ann [Verfasser]. "Extracellular vesicles as cancer liquid biopsy biomarker / Soo Ann Yap." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2021. http://d-nb.info/1234982889/34.

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7

Diop, Fary. "Diffuse large B-cell lymphoma genotyping on the liquid biopsy." Doctoral thesis, Università del Piemonte Orientale, 2018. http://hdl.handle.net/11579/105207.

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Accessible and real-time genotyping for diagnostic, prognostic, or treatment purposes is increasingly impelling in diffuse large B-cell lymphoma (DLBCL). Cell-free DNA (cfDNA) is shed into the blood by tumor cells undergoing apoptosis and can be used as source of tumor DNA for the identification of DLBCL mutations, clonal evolution, and genetic mechanisms of resistance. In this study, we aimed at tracking the basal DLBCL genetic profile and its modification upon treatment using plasma cfDNA. Ultra-deep targeted next generation sequencing of pretreatment plasma cfDNA from DLBCL patients discove

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Bracht-Loman, Jillian Wilhelmina Paulina. "Validation of liquid biopsy-based analysis on the NanoString nCounter platform." Doctoral thesis, Universitat Autònoma de Barcelona, 2021. http://hdl.handle.net/10803/672549.

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L'avaluació dels marcadors moleculars en teixit tumoral per predir el pronòstic del càncer i la resposta al tractament, també coneguda com a tractament personalitzat, ha transformat la pràctica clínica per a molts tipus de càncer. Es va descobrir que aquesta teràpia dirigida per genotipar, millora la supervivència del pacient i per tant s'han introduït diverses plataformes tècniques en els laboratoris clínics. No obstant això, no tots els tumors es poden biopsiar i, sovint, les quantitats de teixit són insuficients per a la caracterització del tumor. L'ARN, l'ADN i les proteïnes lliures circul

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9

MARALANI, Mahafarin. "Liquid Biopsy: A Next Generation Diagnostic And Prognostic Tool In Solid Malignancies." Doctoral thesis, Università degli Studi di Palermo, 2020. http://hdl.handle.net/10447/401539.

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DO, REGO BARROS FERNANDES LIMA MARIA AUGUSTA. "Investigating Label-Free markers at Nanoscale for Liquid Biopsy Using Multimodal Microscopy." Doctoral thesis, Università degli Studi di Trieste, 2021. http://hdl.handle.net/11368/2995896.

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Liquid biopsy emerges as a noninvasive, easily repeatable, and potentially low-cost approach alternative to standard tissue biopsy. In most cases, it can be used to investigate the cause of symptoms or to help diagnose a number of different health conditions. Although originally used to designate analysis of non-solid tissues to screen for cancer cells, liquid biopsy also refers to the investigation of other general body fluids including its constituents characterization and not necessarily related to cancer. In this thesis, three new applications for the usage of label-free markers in the an

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11

Rauof, Goran, and Jonas Jägerback. "Utvecklingen av ett produktsystem för bättre och billigare cancerdiagnostik : Framtagning av engångskassett och tillhörande basenhet för isolering av cirkulerande och andra suspenderade tumörceller." Thesis, KTH, Maskinkonstruktion (Inst.), 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-99301.

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Det här examensarbetet består i ett produktutvecklingsprojekt som utfördes i samarbete med Liquid Biopsy AB. Syftet med arbetet var att utveckla ett engångskassettsbaserat produktsystem baserat på företagets patentsökta metod för isolering av cancer celler i suspension, inklusive cirkulerande tumörceller. Liquid Biopsy AB är ett svenskt utvecklingsbolag som baserat på ny och unik teknik, är oberoende av proteinmarkörer, använder cirkulerande tumörceller och andra suspenderade tumörceller för att möjliggöra bättre och billigare cancerdiagnostik. Examensarbetet har fokuserat på utvecklingen av e

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IANZA, ANNA. "VALIDATION OF PREDICTIVE AND PROGNOSTIC BIOMARKERS AS A GUIDE FOR A PERSONALIZED APPROACH IN SOLID TUMOURS." Doctoral thesis, Università degli Studi di Trieste, 2020. http://hdl.handle.net/11368/2973745.

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Breast cancer (BC), Colorectal Cancer (CRC) and Non-Small Cell Lung Cancer (NSCLC) are among the most commonly diagnosed solid tumors, and occupy the first places in the mortality rankings. Compared to an old fashioned one-size-fits-all approach, precision medicine offers the possibility to accurately choose the most appropriate therapeutic strategy, that fits the patients not only from the clinical (age, comorbidities) but also from a molecular point of view. A genetic and biological understanding of the tumor, integrated with a weighted analysis of results can help the clinician in designing

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SANTORELLI, LUCIA. "Proteomic analysis of urine-based liquid biopsy to provide new insights into renal diseases." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2020. http://hdl.handle.net/10281/263397.

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L'area di indagine delle paotlogie renali è un campo ampio e complesso e molte delle cause che sono alla loro base non sono completamente comprensibili o curabili. A tal motivo, oltre ad una migliore comprensione della loro eziopatogenesi, è necessario individuare in maniera precisa i fattori di rischio, al fine di migliorare la prognosi e personalizzare il trattamento terapico. Lo sviluppo e l’implementazione di nuovi approcci, come l'analisi proteomica basata sulle urine, come biopsia liquida è attualmente una delle scelte più giuste da compiere. Infatti, l'uso dell'analisi proteomica per la

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Hamid, Faysal-Bin. "Genetic profiling of circulating tumour cells and DNAs in patients with colorectal carcinoma." Thesis, Griffith University, 2021. http://hdl.handle.net/10072/404861.

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Over the decades, it has been considered that blood-based biopsy or liquid biopsy could be an alternative approach of tumour biopsy. To date, blood-based biomarkers such as circulating tumour cell (CTC) and circulating tumour DNA (ctDNA) have been widely studied and found their significance in patients with several carcinomas including colorectal carcinoma (CRC). Biologically, both CTC and cell-free DNA (cfDNA) have been released from the tumour and circulate freely in the blood. Although they are present in trivial quantity due to minute scale of discharge and rapid clearance from the blood,

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Franceschini, Gian Marco. "The DNA methylation landscape of metastatic prostate cancer: from characterization to liquid biopsy applications." Doctoral thesis, Università degli studi di Trento, 2023. https://hdl.handle.net/11572/364210.

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Epigenetic alterations are observed in virtually all cancer types, yet there is limited understanding of their role in tumorigenesis and evolution. The role of DNA methylation has been particularly elusive in this context. While this epigenetic mark has been extensively profiled in healthy and cancerous samples, our ability to understand its relationship with underlying biological processes is still limited. Moreover, recent advancements in the profiling of cell-free DNA in circulation have sparked renowned attention toward tissue-specific and cancer-specific DNA methylation patterns. In this

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VANNI, VALERIA STELLA. "UTERINE FLUID EXTRACELLULAR VESICLES AS A LIQUID BIOPSY FOR THE DIAGNOSIS OF ENDOMETRIAL RECEPTIVITY." Doctoral thesis, Università Vita-Salute San Raffaele, 2022. http://hdl.handle.net/20.500.11768/133079.

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Introduction. Implantation rates in Assisted Reproduction Technologies (ART) are still suboptimal due to a contribution of both embryonic and endometrial factors. While diagnosis of embryo euploidy can be achieved through preimplantation genetic testing, the diagnosis of a receptive endometrium remains a challenge. The main limitation of current receptivity tests based on the transcriptome of endometrial biopsies are that they: i) overlook the extracellular compartment, which appears to play a major role in the implantation-related cross-talk; ii) cannot be performed in the same cycle of the e

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SAGIRAJU, Sruthi. "Liquid biopsy provides complementary information to tissue biopsies for molecular classification of DLBCL patients." Doctoral thesis, Università del Piemonte Orientale, 2022. http://hdl.handle.net/11579/144258.

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Diffuse large B-cell lymphoma is a molecular heterogeneous disease with a variable clinical course and prognosis. Recent studies have identified different molecular clusters on tissue biopsy. Liquid biopsy is a non-invasive tool that allows the collection of circulating tumor DNA (ctDNA) shed by apoptotic tumor cells potentially deriving from all the different sites of the lymphoma. This may provide an integrative source of tumor DNA for DLBCL genotyping. The aims of the study are: i) to identify new prognostic molecular markers on ctDNA and on lymph node biopsy (LN); and ii) to compare the DL

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18

Bollu, Bapesh Krishna. "Circulating Tumour Cells in Osteosarcoma." Thesis, The University of Sydney, 2022. https://hdl.handle.net/2123/29874.

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Introduction There is now a growing body of work being conducted in the field of liquid biopsies. A liquid biopsy is a technique to look for biomarkers, arising from cancer, within the blood stream which are accessed in a non-invasive manner. These may include circulating tumour cells (CTCs), circulating tumour DNA, circulating RNA or exosomes. Osteosarcoma is the most common bony malignancy of the paediatric population. Metastatic disease has a poor prognosis with a 20-30% survival. The number of tumour cells present at distant sites when identified by traditional radiological and clini

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Silva, Luciana Sanches. "Pesquisa de células tumorais circulantes em pacientes com câncer de próstata por método de filtração celular." Botucatu, 2018. http://hdl.handle.net/11449/155896.

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Orientador: Adriana Polachini Valle<br>Resumo: Introdução: O câncer de próstata (CP) é o mais incidente entre os homens em todas as regiões do Brasil. A detecção e caracterização de células tumorais circulantes (CTCs) tem sido apontada como uma alternativa para melhor compreensão da biologia dos tumores, incluindo câncer de próstata. Objetivo: Este estudo tem como objetivo avaliar a detecção de CTCs em pacientes com tumor de próstata localizado e metastático por teste rápido de filtração celular. Metodologia: Foram incluídos pacientes com diagnóstico anatomopatológico de câncer de próstata ou

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20

Orlando, Francesco. "Unleashing the potential of liquid biopsy: allele-informed evaluation of plasma samples for cancer patients management." Doctoral thesis, Università degli studi di Trento, 2023. https://hdl.handle.net/11572/364264.

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Liquid biopsy and next-generation sequencing of cell-free DNA (cfDNA) in cancer patients’ plasma offer a minimally-invasive solution to detect tumor cell genomic information to aid real-time clinical decision-making. Reliability and sensitivity in the detection of genomic alterations is crucial for patient management and it is particularly relevant in the context of targeted therapies. However, biological and technical factors, such as low cfDNA tumor fraction and sequencing errors, affect the correct interpretation of genomic data limiting the utility of non-invasive cfDNA-based tumor profili

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Afrogheh, Amir. "An evaluation of Shandon Papspin liquid based oral test utilizing a novel cytologic scoring system." Thesis, University of the Western Cape, 2010. http://etd.uwc.ac.za/index.php?module=etd&action=viewtitle&id=gen8Srv25Nme4_4355_1360592750.

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<p>Background and Aims: While a single &ldquo<br>high quality&rdquo<br>oral liquid based cytology (LBC) study has shown a high sensitivity and specificity for the technique in detection of oral dysplasia and malignancy, the high unit cost of this technology cannot be borne by the developing African countries. This study aims to evaluate the efficiency of an alternative cost-effective technique, Shandon PapSpin (PS) LBC in&nbsp<br>diagnosis of oral and oropharyngeal dysplasia and malignancy. Materials and Methods.We compared the diagnostic accuracy of Shandon PS LBC with that of scalpel biopsy

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De, Mattos Arruda Leticia. "Genomic characterisation of brain malignancies through liquid biopsies: The cerebrospinal fluid-derived circulating tumour DNA better represents the genomic alterations of brain tumours than plasma." Doctoral thesis, Universitat Autònoma de Barcelona, 2016. http://hdl.handle.net/10803/394019.

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Los recientes avances en la secuenciación masiva en paralelo y en las técnicas genómicas digitales apoyan la validez clínica del ADN libre tumoral circulante (ctDNA) como una "biopsia líquida” en el cáncer humano. La presencia de ctDNA en el plasma puede ser útil para identificar alteraciones genómicas, monitorizar la respuesta al tratamiento, identificar la resistencia terapéutica, y potencialmente caracterizar la heterogeneidad del tumor. El estudio de prueba de concepto en el campo de las biopsias líquidas titulado “Capturing intra-tumor genetic heterogeneity by de novo mutation profiling

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Hilke, Franz Joachim [Verfasser]. "Genetische Charakterisierung und Therapieüberwachung von fortgeschrittenen Tumorerkrankungen mit Hilfe der Hochdurchsatzsequenzierung und Liquid Biopsy / Franz Joachim Hilke." Tübingen : Universitätsbibliothek Tübingen, 2021. http://d-nb.info/1230796525/34.

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Cayron, Helene. "Sélection et capture de biomarqueurs moléculaires et cellulaires à partir d'un fluide complexe." Thesis, Toulouse, INSA, 2016. http://www.theses.fr/2016ISAT0001.

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Ce travail de thèse s'est axé autour de deux approches technologiques issues du domaine de la microfabrication pour la sélection et la capture de biomarqueurs circulants dans le sang. A l'échelle moléculaire, un module d'assemblage capillaire dirigé a été implémenté dans un automate de tamponnage moléculaire puis validé en utilisant un modèle simple, permettant l'isolement et l'étirement de biomolécules individuelles de manière entièrement contrôlée et automatisée à large échelle. Nous avons ensuite appliqué cette technologie à des biomarqueurs moléculaires d'intérêt tels que les ADN libres co

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Jimenez, Zenteno Alejandro Kayum. "Micro-dispositifs pour l'isolement des cellules tumorales circulantes en routine clinique." Thesis, Toulouse 3, 2018. http://www.theses.fr/2018TOU30154.

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Les cellules tumorales circulantes (CTCs) sont la principale voie de dissémination du cancer dans le corps humain au travers de la circulation sanguine. Ces cellules ont la capacité de se détacher de la tumeur primaire, de rejoindre la circulation sanguine et de survivre dans cet environnement. Une sous-population spécifique de ces cellules a la capacité de coloniser de nouveaux tissus et de former des métastases. L'importance de ces cellules rares dans la circulation sanguine a été intensément étudiée au cours des dernières décennies, et il a été constaté que les informations phénotypiques et

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Notarangelo, Michela. "Exploiting extracellular vesicles for ultrasensitive detection of cancer biomarkers from liquid biopsies." Doctoral thesis, Università degli studi di Trento, 2019. http://hdl.handle.net/11572/243195.

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Extracellular vesicles (EVs) are small membrane-surrounded structures containing transmembrane proteins and enclosing cytosolic proteins and nucleic acids. They are released in the extracellular space by both normal and neoplastic cells and play an important role in cell-cell communication in numerous physiological processes and pathological conditions, through the transfer of their functional cargo to recipient cells. EVs are highly abundant in biological fluids, and even more represented in cancer patients’ biofluids, therefore many studies suggested that they can be instrumental in liquid b

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Notarangelo, Michela. "Exploiting extracellular vesicles for ultrasensitive detection of cancer biomarkers from liquid biopsies." Doctoral thesis, Università degli studi di Trento, 2019. http://hdl.handle.net/11572/243195.

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Extracellular vesicles (EVs) are small membrane-surrounded structures containing transmembrane proteins and enclosing cytosolic proteins and nucleic acids. They are released in the extracellular space by both normal and neoplastic cells and play an important role in cell-cell communication in numerous physiological processes and pathological conditions, through the transfer of their functional cargo to recipient cells. EVs are highly abundant in biological fluids, and even more represented in cancer patients’ biofluids, therefore many studies suggested that they can be instrumental in liquid b

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Chudasama, Dimple. "Discovery and development of liquid biomarkers for ovarian and lung cancer." Thesis, Brunel University, 2018. http://bura.brunel.ac.uk/handle/2438/16174.

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Survival rates in cancers have improved vastly over the years. However, some survival rates remain extremely low, as is the case for ovarian and lung cancer. The lack of robust and reliable biomarkers is strongly reflected in the absence of pre-screening programs, and as such, most patients in these cancer types are diagnosed only in advanced stages, leaving few treatment options. Moreover, relapse and resistance to therapies adds to the complexities of treating these diseases, even in the era of targeted drug development. Research has shown the presence of cancer material, in the form of circ

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Sagot, Matthieu. "Détection électrique In-Situ des événements de microfiltration dans des milieux complexes." Electronic Thesis or Diss., Université de Toulouse (2023-....), 2024. http://www.theses.fr/2024TLSEP028.

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La microfiltration constitue un domaine scientifique et technologique bien documenté, mais qui nécessite encore des recherches approfondies lorsqu'il s'agit de cibler la filtration spécifique et précise d'éléments rares au sein d'un milieu complexe. En effet, des solutions innovantes pour le filtrage d'échantillons dans des milieux complexes pourraient être la clé de multiples problématiques liées à la santé et à l'environnement. Le sang est un exemple concret de milieu complexe : il contient une quantité importante et variée de cellules et de protéines, présentant une viscosité trois à huit f

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AWAN, ZUBAIR ANWAR. "De novo liquid biopsy and radio genomic diagnostic approach with combined deep learning artificial neural networks for NSCLC." Doctoral thesis, Università degli Studi di Palermo, 2022. https://hdl.handle.net/10447/564144.

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Each year, the mortality rate and incidence of non-small cell lung cancer (NSCLC) are dramatically increasing. The introduction of liquid biopsy in the clinical practice of NSCLC has completely revolutionized the approach to such neoplasm since is generally detected through complex and invasive procedures and unfortunately at advanced stages. The importance and innovation of liquid biopsy are linked with the possibility of cancer detection at every stage, adjuvant treatment, resistance genotyping, systematic initiation of treatment, minimal residual disease, early detection of relapse, a

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Martel, Arnaud. "Impact de la biopsie liquide dans le mélanome uvéal primitif et métastatique." Electronic Thesis or Diss., Université Côte d'Azur, 2023. http://www.theses.fr/2023COAZ6050.

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Le mélanome uvéal (MU) est le cancer intraoculaire primitif le plus fréquent chez l'adulte. Malgré une prise en charge médico-chirurgicale adaptée permettant un contrôle local de la tumeur dans plus de 90% des cas, on estime qu'environ 50% des patients présenteront des métastases, principalement hépatiques, dans les 10 années suivant le diagnostic. La dissémination métastatique du MU s'effectue uniquement par voie hématogène. Détecter le plus précocement possible la présence de cellules tumorales dans le sang circulant permettrait une prise en charge très précoce des patients, avant la survenu

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Sanz, García Enrique. "Análisis de RAS en plasma en cáncer colorrectal metastásico: impacto de la fracción mutante alélica en pronóstico." Doctoral thesis, Universitat Autònoma de Barcelona, 2018. http://hdl.handle.net/10803/666000.

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Introducción: A pesar de los importantes avances en el tratamiento del cáncer de colon metastásico (mCRC), la supervivencia sigue siendo corta. Existen diversos factores pronósticos y predictivos que se han de tener en cuenta, entre ellos la mutación del oncogén RAS presente en más del 40% de tumores. Esta mutación suele ser determinada en tejido sólido pero dada la imposibilidad en ocasiones de obtener suficiente muestra y la heterogeneidad tumoral, la determinación de dicha mutación en el DNA circulante en sangre (biopsia líquida) puede ser realizada por ejemplo mediante BEAMing (basada en l

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Kalubowilage, Madumali. "Liquid biopsies of solid tumors: non-small-cell lung and pancreatic cancer." Diss., Kansas State University, 2017. http://hdl.handle.net/2097/35385.

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Doctor of Philosophy<br>Department of Chemistry<br>Stefan H. Bossmann<br>Cancer is a group of diseases that are characterized by uncontrolled growth and spread of cells. In order to treat cancer successfully, it is important to diagnose cancers in their early stages, because survival often depends on the stage of cancer detection. For that purpose, highly sensitive and selective methods must be developed, taking advantage of suitable biomarkers. The expression levels of proteases differ from one cancer type to the other, because different cancers arise from different cell types. According to t

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Hisey, Colin Lee Hisey. "Microfluidic Devices for Clinical Cancer Sample Characterization." The Ohio State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=osu1525783108483419.

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Romagnoli, Dario. "Identification and development of epigenetic tumor biomarkers through computational biology approaches." Doctoral thesis, Università di Siena, 2023. https://hdl.handle.net/11365/1227695.

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DNA-methylation alterations are common in cancer and display unique characteristics that make them ideal markers for tumor quantification and classification. In this study, we discuss the development and testing of a computational framework exploiting minimal DNA-methylation signatures composed by a few dozen informative DNA-methylation sites to quantify and classify tumor signals in tissue and cell-free DNA samples. Extensive analyses of multiple independent and heterogenous datasets including >7,200 samples demonstrate the capability of the framework to provide precise estimations of tumo

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GRISTINA, Valerio. "Circulating cell-free DNA (cfDNA) and extracellular vesicles (EVs) as prognostic and predictive biomarkers in patients with advanced Non-Small Cell Lung Cancer (NSCLC): the LEXOVE prospective study." Doctoral thesis, Università degli Studi di Palermo, 2022. https://hdl.handle.net/10447/571952.

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Heeke, Simon. "Développement et implémentation de nouveaux biomarqueurs prédictifs dans le cancer du poumon non à petites cellules - du tissu à la biopsie liquide." Electronic Thesis or Diss., Université Côte d'Azur (ComUE), 2019. http://www.theses.fr/2019AZUR6015.

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Le cancer du poumon est la principale cause de décès liés au cancer dans le monde, tant chez les hommes que chez les femmes. Cependant, le traitement du cancer du poumon a radicalement changé au cours de ces dernières années avec la mise en place de chimiothérapies plus efficaces, mais surtout le développement de traitements ciblés qui permettent une approche thérapeutique personnalisée et avec l'introduction de l'immunothérapie qui a considérablement prolongé la survie de certains patients atteints d’un cancer du poumon non à petites cellules (CPNPC). Bien que ces nouvelles approches thérapeu

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Julich-Haertel, Henrike [Verfasser], and Veronika [Akademischer Betreuer] Lukacs-Kornek. "Microparticles – A novel liquid biopsy tool to identify and classify primary hepatic cancer / Henrike Julich-Haertel ; Betreuer: Veronika Lukacs-Kornek." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2018. http://d-nb.info/1173703349/34.

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Lázaro, Fortunato Diogo Miguel. "Characterization and selective isolation of human extracellular vesicle subpopulations from simple and complex biosamples for novel clinical liquid biopsy strategies." Doctoral thesis, Università di Siena, 2022. http://hdl.handle.net/11365/1213357.

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All living cells selectively package a wide variety of biomolecules in nanometric entities termed extracellular vesicles (EVs), which actively mediate vital biological events, especially biomolecule recycling and horizontal intercellular communication. To do so, EVs can diffuse through interstitial space, reaching even circulating biofluids to promote long-range paracrine signalling in recipient cells, while sometimes directly functioning as effectors. Despite fundamental knowledge gaps within the field, EVs are frequently dysregulated during disease, often directly sustaining disease hallmark

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GASPARELLO, Jessica. "Novel trands in microRNA based theranostics." Doctoral thesis, Università degli studi di Ferrara, 2018. http://hdl.handle.net/11392/2478767.

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I miRNA sono una classe di RNA non codificanti in grado di regolare l’espressione genica attraverso l’interazione con la regione 3’UTR del trascritto bersaglio, portando all’inibizione della traduzione o alla degradazione del mRNA bersaglio. A causa della loro breve sequenza (19-25 nucleotidi), i miR sono in grado di riconoscere regioni bersaglio in più trascritti, risultando, coinvolti in più di un processo molecolare. Diverse patologie sono state associate alla disregolazione del profilo di espressione di miR, negli anni sono state quindi elaborate diverse strategie terapeutiche allo scopo d

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Taus, García Álvaro. "Estudio de mutaciones de EGFR y KRAS en ADN circulante en pacientes afectos de cáncer de pulmón de célula no pequeña." Doctoral thesis, Universitat Autònoma de Barcelona, 2021. http://hdl.handle.net/10803/671917.

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L'anàlisi molecular de l'tumor s'ha convertit en un procediment fonamental per a definir el maneig dels pacients amb càncer de pulmó. Encara que l'anàlisi de el teixit tumoral es considera la tècnica d'elecció per a l'estudi molecular, aquesta aproximació té una sèrie de limitacions, com l'absència de material tumoral suficient o la impossibilitat per capturar l'heterogeneïtat tumoral. L'ús de la biòpsia líquida podria ajudar a superar aquestes limitacions. En aquest treball analitzem la capacitat de la biòpsia líquida de detectar mutacions de EGFR o KRAS en plasma. Utilitzant la biòpsi

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Schneegans, Svenja Verfasser], and Susanne [Akademischer Betreuer] [Dobler. "The putative role of HERC5 in NSCLC metastasis and its potential utility as a liquid biopsy marker / Svenja Schneegans ; Betreuer: Susanne Dobler." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2020. http://nbn-resolving.de/urn:nbn:de:gbv:18-105564.

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Schneegans, Svenja [Verfasser], and Susanne [Akademischer Betreuer] Dobler. "The putative role of HERC5 in NSCLC metastasis and its potential utility as a liquid biopsy marker / Svenja Schneegans ; Betreuer: Susanne Dobler." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2020. http://d-nb.info/121481154X/34.

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PASSIGLIA, Francesco. "Immune-Biomarkers in Advanced Non-Small Cell Lung Cancer." Doctoral thesis, Università degli Studi di Palermo, 2021. http://hdl.handle.net/10447/514194.

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N.A<br>Background: Developing personalized immunotherapy-based approaches, through the identification of predictive immune-related biomarkers, is still a main topic for translational lung cancer research. In the present study we investigated whether baseline tissue “immune-related gene signatures”, as well as plasma chemo-cytokines profiles, could predict sensitivity/resistance to immune-checkpoint inhibitors in pre-treated patients with advanced non-small cell lung cancer (NSCLC). Methods: From September 2015 to September 2018, 150 patients with previously treated advanced NSCLC who rec

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DEL, BEN FABIO. "A SINGLE-CELL METABOLIC ASSAY FOR THE DETECTION OF CIRCULATING TUMOR CELLS." Doctoral thesis, Università degli Studi di Trieste, 2016. http://hdl.handle.net/11368/2908085.

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The number of circulating tumor cells (CTCs) in blood is strongly correlated with the progress of metastatic cancer and can be used as a diagnostic tool to improve staging, therapy-monitor and recurrence detection. Current FDA-approved device to detect CTCs is based on immunostaining with limitations in sensitivity range, high-cost per analysis and lack of viable cell isolation. Other techniques are emerging, though none of them reached clinical validation. Here, we present an unexplored label-free method exploiting the abnormal metabolic behaviour of cancer cells (extracellular acidification,

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Fuh, Marceline Manka [Verfasser], and Hartmut [Akademischer Betreuer] Schlüter. "Investigation of extracellular vesicles from glioblastoma multiforme and meningioma patients for cancer liquid biopsy by differential quantitative proteomics / Marceline Manka Fuh ; Betreuer: Hartmut Schlüter." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2019. http://d-nb.info/1197801480/34.

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Schier, Wiebke Henrike [Verfasser], and Arne [Akademischer Betreuer] Trummer. "Etablierung einer Liquid Biopsy zur Detektion einer BTK Resistenzmutation bei Patienten unter Ibrutinib-Therapie / Wiebke Henrike Schier ; Akademischer Betreuer: Arne Trummer ; Städtisches Klinikum Braunschweig." Hannover : Bibliothek der Medizinischen Hochschule Hannover, 2019. http://d-nb.info/1201824826/34.

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Clark, Michael Edward. "Unravelling the potential applications of extracellular vesicles for the clinical management of melanoma patients." Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 2021. https://ro.ecu.edu.au/theses/2485.

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Metastatic melanoma is the third most common cancer in Australia with global incidence increasing. After decades without effective systemic treatments for advanced melanoma, the advent of targeted and immune therapies has substantially improved patient survival. While this is encouraging, further research is needed as the majority of patients treated with targeted therapy ultimately develop drug resistance. Immunotherapy can achieve durable responses in many patients however, not all patients respond to current single or a combination of immune checkpoint inhibitors. Considering the cost and p

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BONO, Marco. "Multigene panel testing in Hereditary Breast and Ovarian Cancer: an effective liquid biopsy approach to identify mutations in genes involved in the Homologous Recombination pathway." Doctoral thesis, Università degli Studi di Palermo, 2021. http://hdl.handle.net/10447/479959.

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Background: Hereditary breast and ovarian cancer (HBOC) syndrome is an autosomal dominant inherited disorder that include 5–7% of all breast cancer (BC) cases and 10-15% of all ovarian cancer (OC) cases. BRCA1 and BRCA2 are the most common genes associated to HBOC syndrome. However, hereditary syndrome could be associated with germline PVs in several high- and moderate-risk genes. In recent years, Next-Generation Sequencing (NGS) has allowed to study multiple genes simultaneously, to reduce analysis costs, to led to an explosion of genetic data, and to offer more information to patients. Meth

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Kuhlmann, Jan Dominik [Verfasser], Sabine [Akademischer Betreuer] Kasimir-Bauer, Stephan [Akademischer Betreuer] Hahn, and Ralf [Akademischer Betreuer] Küppers. "Identifizierung neuer Biomarker für das Ovarialkarzinom – : Primärtumorbasierte Analysen und blutbasierte „Real-Time-Liquid-Biopsy“ / Jan Dominik Kuhlmann. Gutachter: Stephan Hahn ; Ralf Küppers. Betreuer: Sabine Kasimir-Bauer." Duisburg, 2013. http://d-nb.info/1035066416/34.

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