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Dissertations / Theses on the topic 'Liquid chromatography research'

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1

Wong, Victor, University of Western Sydney, of Science Technology and Environment College, and of Science Food and Horticulture School. "A fundamental study towards improving the performance of liquid chromatographic separation." THESIS_CSTE_SFH_Wong_V.xml, 2003. http://handle.uws.edu.au:8081/1959.7/467.

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The three factors of the resolution (Rs)equation(see Equation 1.1)were explored in this thesis. During the course of the research project, an important aim was to explore separation processes that would lead to an increase in productivity without sacrificing Rs. To that end, an increase in the retention factor (k)to enhance Rs was deemed detrimental to the cycle time, hence the production rate, particularly when preparative separations are involved. Consequently the primary objectives were to (i)prepare more efficient columns and (ii)investigate new strategies in manipulating selectivity. The
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2

Wilson, William Henry. "Packed capillary columns for liquid chromatography." Diss., Virginia Tech, 1990. http://hdl.handle.net/10919/37746.

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3

Wong, Victor. "A fundamental study towards improving the performance of liquid chromatographic separation." Thesis, View thesis, 2003. http://handle.uws.edu.au:8081/1959.7/467.

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The three factors of the resolution (Rs)equation(see Equation 1.1)were explored in this thesis. During the course of the research project, an important aim was to explore separation processes that would lead to an increase in productivity without sacrificing Rs. To that end, an increase in the retention factor (k)to enhance Rs was deemed detrimental to the cycle time, hence the production rate, particularly when preparative separations are involved. Consequently the primary objectives were to (i)prepare more efficient columns and (ii)investigate new strategies in manipulating selectivity. The
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4

Alsugair, Khaled A. S. "Feasibility of artificial cells in molecular sieve chromatography." Thesis, McGill University, 1987. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=63922.

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5

Motley, Curtis Bobby. "The evaluation of an argon and helium highly efficient microwave induced plasma as an element selective detector for packed column super critical fluid chromatography." Diss., Virginia Tech, 1990. http://hdl.handle.net/10919/37740.

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6

Murphy, Kellyann M. "Analysis of Biodiesel Quality Using Reversed Phase High-Performance Liquid Chromatography." Scholarship @ Claremont, 2012. http://scholarship.claremont.edu/pomona_theses/45.

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The alternative fuel biodiesel is produced from the transesterification of vegetable oils or animal fat to fatty acid methyl esters. Pomona has a reactor on campus that can be used to run this reaction and produce biodiesel. The use of biodiesel has been found to lower air pollutant and greenhouse gas emissions, but can be potentially harmful to the engines if it contains impurities. This paper proposes a method using high-performance liquid chromatography to test the quality of biodiesel. This method utilizes instrumentation and materials that are available in Pomona College's Chemistry Depar
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7

Li, Shangfu. "Development of chemical derivatization methods for cis-diol-containing metabolite detection by using liquid chromatography-mass spectrometry." HKBU Institutional Repository, 2016. https://repository.hkbu.edu.hk/etd_oa/323.

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Cis-diol-containing metabolites have attracted increasing attention in recent years. These metabolites widely exist in the body fluids and tissues. They play important roles in the structure, function and metabolic activity of cells. Some of them are related to cell proliferation and metabolic processes. And they have been used to denote a state of disease as potential biomarkers. Several methods have been developed for the analysis of cis-diol-containing metabolites. However, these methods faced a challenge to separate and detect isomers of these compounds, particularly for compounds with low
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8

Swensen, Adam Clayton. "Investigation of Dynamic Biological Systems Using Direct Injection and Liquid Chromatography Mass Spectrometry." BYU ScholarsArchive, 2016. https://scholarsarchive.byu.edu/etd/6574.

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In biological systems, small changes can have significant impacts. It is, therefore, very important to be able to identify these changes in order to understand what is occurring in the organism. In many cases, this is not an easy task. Mass spectrometry has proven to be a very useful tool in elucidating biological changes even at a very small scale. Several different mass spectrometry based techniques have been developed to discover and investigate complex biological changes. Some of these techniques, such as proteomics, have been through years of development and have advanced to the point tha
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9

Goodpaster, Aaron M. "Statistical Analysis Methods Development for Nuclear Magnetic Resonance and Liquid Chromatography/Mass Spectroscopy Based Metabonomics Research." Miami University / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=miami1312317652.

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10

Lai, Yongquan. "Development and application of liquid chromatography mass spectrometry methods for the analysis and toxicity study of polybrominated diphenyl ether metabolites." HKBU Institutional Repository, 2012. https://repository.hkbu.edu.hk/etd_ra/1437.

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11

Surindar, Singh Gurmeet Kaur. "Liquid Chromatography Tandem Mass Spectrometry Measurements of Steroids in Biological Samples for Clinical Research Studies: Methodology and Application." Thesis, The University of Sydney, 2015. http://hdl.handle.net/2123/13664.

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The advent of liquid chromatography tandem mass spectrometry (LC-MS/MS) coupled with soft ionization method has expanded the scope for measurement of steroids from biological matrices with higher accuracy, specificity, sensitivity and requires less sample preparation. The overall aim of this study is to develop and validate LC-MS/MS methods to measure steroids from biological samples for clinical research studies. A sensitive and specific LC-MS/MS assay was developed and validated to measure steroids from dried blood spots (DBS) samples to assess the feasibility and pharmacology of subcutaneou
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12

Chan, Wan. "Development and application of liquid chromatography and electrospray-ionization mass spectrometry methods for herbal medicine analysis and for the studies of metabolism, DNA adducts and metabonomics of aristolochic acids." HKBU Institutional Repository, 2007. http://repository.hkbu.edu.hk/etd_ra/891.

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13

Aguiar, Mike. "Applications of mass spectrometry in clinical chemistry and biomedical research." Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=108330.

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Note:<br>Clinical chemistry is a medical discipline whose aim is to diagnose and assess disease by analysis of biological specimens. Modem laboratories can perform several hundred different tests using many different methods developed over the last century. The classical, more traditional assays are typically labour-intensive, not multiplexed (only measure one analyte or disorder per assay), expensive, require a long turnaround time, and may not provide adequate sensitivity and specificity. Developments in mass spectrometry (MS) and related technologies over the last two decades have provided
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14

Childress, Beverly Bibera. "Nitric oxide metabolites in wound fluids from pressure ulcers on v.a.c.(tm) therapy." [Gainesville, Fla.] : University of Florida, 2004. http://purl.fcla.edu/fcla/etd/UFE0005140.

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Thesis (Ph.D.)--University of Florida, 2004.<br>Typescript. Title from title page of source document. Document formatted into pages; contains 84 pages. Includes Vita. Includes bibliographical references.
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15

Nemukula, Aluwani. "Purification and characterization of fructosyltransferase for the synthesis of short-chain fructo-oligosaccharides and investigation into thier anti-carcinogenic properties." Thesis, Rhodes University, 2009. http://hdl.handle.net/10962/d1003986.

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There is a growing attention in the synthesis of fructo-oligosaccharides (FOS) due to their excellent bio-functional and health-promoting properties. The current production processes are limited to chemical hydrolysis reactions of plant extracts, which are often associated with several drawbacks. In this study, fructosyltransferase (FTase) and polygalacturonase (PGase) activities, present in a commercial enzyme preparation (Pectinex® Ultra SP-L) sourced from Aspergillus aculeatus, have been separated and fully purified by anion-exchange and sizeexclusion chromatography. The FTase possesses fru
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16

Muir, Matthew Stewart. "Proteomics of the ovine cataract." Diss., Lincoln University, 2008. http://hdl.handle.net/10182/792.

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The lens of the eye needs to be completely transparent in order to allow all light entering the eye to reach the retina. This transparency is maintained by the highly ordered structure of the lens proteins the crystallins. Any disruption to the lens proteins can cause an opacity to develop which is known as cataract. During cortical cataract formation there is increased truncation of the lens crystallins. It is believed that overactivation of calcium-dependent cysteine proteases, the calpains, is responsible for the increased proteolysis of the crystallins seen during cataractogenesis. Within
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17

Mnguni, Sibusiso Blessing. "Determination of estrogenic hormones in environmental water samples in Vaal region by Ultra Fast Liquid Chromatography coupled to Mass Spectrometry." Thesis, 2016. http://hdl.handle.net/10539/21720.

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A dissertation submitted to the Faculty of Science, University of the Witwatersrand, Johannesburg, in fulfilment of requirements for the degree of Master of Science. Johannesburg, 2016.<br>The presence of estrogenic hormones in the environment has been a subject of concern in recent years; they have been classified as “emerging pollutants” and may pose a potential risk for human consumption. Hormones have been detected in ground and surface water at low concentrations. These compounds contaminate the surface and ground water via waste water treatment plants (WWTP) and may elicit endocrine disr
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18

Oliver, James D. "Investigating and applying free solution capillary electrophoresis with direct UV detection to bioethanol research." Thesis, 2014. http://handle.uws.edu.au:8081/1959.7/uws:32147.

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Bioethanol fermentation is an important process that is reducing the global demand on fossil fuels and remains a field of research for the foreseeable future. Carbohydrates are sourced from crops and hydrolyzed into simpler sugars then fermented into ethanol. Fermentation of sugars sourced from food crops presents a sustainability issue with a growing population. Fermentation of lignocellulosic material is more sustainable since it is sourced from non-food crops or wastes. It is comprised of a variety of both pentose and hexose sugars. The composition and ratio of these varies depending on the
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