Relevant bibliographies by topics / Liquirizia

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Academic literature on the topic 'Liquirizia'

Author: Grafiati
Published: 21 February 2023

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Journal articles on the topic "Liquirizia"

1

Zhou, Peng, An-lu Shen, Pei-pei Liu, Shu-shu Wang, and Liang Wang. "Molecular docking and in vivo studies of liquiritin against acute myocardial infarction via TLR4/MyD88/NF-κB signaling." Italian Journal of Food Science 34, no. 2 (June 16, 2022): 80–88. http://dx.doi.org/10.15586/ijfs.v34i2.2188.

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Licorice (Glycyrrhiza glabra L.) is an essential herb in Chinese medicine, as well as a common ingredient in health foods and natural sweeteners. Liquiritin, the primary constituent of licorice, possesses a wide range of pharmacological and biological properties. This research aims to study the protective mechanism of liquiritin in the myocardium. The potential therapeutic efficacy of liquiritin against acute myocardial infarction (AMI) was tested using molecular docking and verified using an AMI rat model caused by the ligation of the LAD coronary artery. Molecular docking between liquiritin and toll-like receptor 4 (TLR4) and myeloid differentiation factor 88 (MyD88) was predicted using SystemsDock. Then, for experimental validation, in vivo studies were employed. Rats with the AMI model established by ligation of left anterior descending coronary artery were divided into four groups—sham group, model group, captopril group, and liquiritin group. LVSP, LVEDP, +dp/dtmax, and -dp/ dtmax were detected and analyzed. HE and Masson staining were used to observe the pathological changes. The protein expressions of TLR4, MyD88, and nuclear factorκB p65 (NF-κB p65) were detected by Western blotting. Molecular docking showed that liquiritin may act on the TLR4 and MyD88, and, therefore, liquiritin was pre-dicted to exert anti-inflammatory effects by regulating the TLR4/MyD88 signaling pathway. Liquiritin improved LVSP, +dp/dtmax, -dp/dtmax, and LVEDP levels, and alleviated pathological changes and cardiac fibrosis. Further study found that liquiritin could decrease the overexpression of TLR4, MyD88, and NF-κB, which validated the molecular docking study. Hence, liquiritin ameliorates AMI by reducing inflammation, and blocking TLR4/ MyD88/NF-κB signaling. These results indicate that liquiritin as a potential compound could alleviate AMI and broaden its application.
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Liu, Chang, Dai Yuan, Chi Zhang, Ye Tao, Ying Meng, Mengli Jin, Wu Song, Bingmei Wang, and Lin Wei. "Liquiritin Alleviates Depression-Like Behavior in CUMS Mice by Inhibiting Oxidative Stress and NLRP3 Inflammasome in Hippocampus." Evidence-Based Complementary and Alternative Medicine 2022 (January 11, 2022): 1–10. http://dx.doi.org/10.1155/2022/7558825.

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Objective. Central inflammation is generally accepted to be involved in the pathology of depression. We investigated whether liquiritin exerts antidepressant effects by inhibiting central NLRP3 inflammasomes. Results. The behavioral despair model and chronic unpredictable mild stress (CUMS) model in mice were established to evaluate the antidepressant action of liquiritin. In the despair model study, liquiritin (40 mg/kg) administration reduced immobility time in tail suspension test (TST) and forced swimming test (FST) without affecting locomotion activity. In CUMS model study, liquiritin (40 mg/kg, once daily for 4 weeks) significantly increased sucrose consumption and body weight of CUMS mice. The behavioral experiment results showed that liquiritin reduced the immobile time of CUMS mice in TST and FST, respectively, and increased the time spent and open arm entries in the elevated plus-maze (EPM) test. Further, the hippocampal superoxide dismutase (SOD) activity was increased in liquiritin-treated group, while malonaldehyde (MDA) decreased. Additionally, the hippocampal cytokines interleukin-18 (IL-18) and interleukin-1 beta (IL-1β) contents were reduced in the liquiritin-treated group. Further, liquiritin downregulated the expression of NLRP3 in the hippocampus of CUMS mice rather than TLR4. Besides, NLRP3 inflammasome-associated proteins caspase-1 and ASC were also downregulated. However, liquiritin did not alter the thermal stability of NLRP3 in the cellular thermal shift assay (CETSA), suggesting that its inhibition of NLPR3 was not by direct targeting of NLRP3 protein. Conclusions. Liquiritin attenuates depression-like behavior of CUMS mice and inhibited cytokines levels triggered by NLRP3 inflammasome, suggesting the antidepressant action is, at least partially, associated with antioxidant stress and inhibition of NLRP3 inflammasome activation.
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Liao, Liangying, and Zhanwei Zhang. "Liquiritin Relieves Oxygen-Glucose Reperfusion-Induced Neuronal Injury via Inhibition of the p38MAPK/NF-κB Signaling Pathway." Revista Brasileira de Farmacognosia 32, no. 2 (March 1, 2022): 221–29. http://dx.doi.org/10.1007/s43450-022-00233-1.

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AbstractIn traditional Chinese medicine, liquiritin, an active component of Glycyrrhiza uralensis Fisch., Fabaceae, has several pharmacological effects such as anticancer, antioxidant, and neuroprotective properties. The present study aimed to explore the protective functions and molecular mechanisms underlying the effects of liquiritin on nerve injury induced by cerebral ischemia/reperfusion. SH-SY5Y cells were incubated with varying concentrations of liquiritin for different periods of time, and 3-(45)-dimethylthiahiazo(-z-y1)-35-di-phenytetrazoliumromide and lactate dehydrogenase assays were employed to determine the levels of cell viability and damage. Subsequently, cells were exposed to oxygen and glucose deprivation/reoxygenation to establish an ischemia/reperfusion injury model. The results revealed that liquiritin protected SH-SY5Y cells from oxygen and glucose deprivation/reoxygenation-induced damage by improving viability and reducing apoptosis, and oxidative stress. Liquiritin inhibited activation of the p38 mitogen-activated protein kinase (MAPK)/nuclear factor kappa B (NF-κB) signaling pathway. In addition, treatment with a p38MAPK-specific agonist reversed the protective effects of liquiritin. Graphical abstract
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4

Cong, Jing Xiang, Shao Yan Wang, and Hong Gao. "Separation of Liquiritin by Two-Dimensional Liquid Chromatography." Advanced Materials Research 455-456 (January 2012): 1232–38. http://dx.doi.org/10.4028/www.scientific.net/amr.455-456.1232.

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Two-dimensional liquid chromatography (2DLC) is an important technology for the separation and analysis of complex samples. Liquiritin, an important active component in licorice, was chosen as the target compound and it was separated by three kinds of off-line 2DLC, i.e. size exclusion chromatography × reversed phase chromatography, normal phase × reversed phase chromatography and reversed phase chromatography × reversed phase chromatography (SEC×RP, NP×RP and RP×RP). The chromatographic conditions were selected and the 2D systems were combined. The results show that it is feasible to separate Liquiritin from licorice extract using 2DLC. Among the 2D modes mentioned above, the highest purity of Liquiritin was obtained in the RP×RP mode, and the concentration of Liquiritin was increased most significantly in the NP×RP mode.
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Han, You Jin, Bitna Kang, Eun-Ju Yang, Min-Koo Choi, and Im-Sook Song. "Simultaneous Determination and Pharmacokinetic Characterization of Glycyrrhizin, Isoliquiritigenin, Liquiritigenin, and Liquiritin in Rat Plasma Following Oral Administration of Glycyrrhizae Radix Extract." Molecules 24, no. 9 (May 10, 2019): 1816. http://dx.doi.org/10.3390/molecules24091816.

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Glycyrrhizae Radix is widely used as herbal medicine and is effective against inflammation, various cancers, and digestive disorders. We aimed to develop a sensitive and simultaneous analytical method for detecting glycyrrhizin, isoliquiritigenin, liquiritigenin, and liquiritin, the four marker components of Glycyrrhizae Radix extract (GRE), in rat plasma using liquid chromatography-tandem mass spectrometry and to apply this analytical method to pharmacokinetic studies. Retention times for glycyrrhizin, isoliquiritigenin, liquiritigenin, and liquiritin were 7.8 min, 4.1 min, 3.1 min, and 2.0 min, respectively, suggesting that the four analytes were well separated without any interfering peaks around the peak elution time. The lower limit of quantitation was 2 ng/mL for glycyrrhizin and 0.2 ng/mL for isoliquiritigenin, liquiritigenin, and liquiritin; the inter- and intra-day accuracy, precision, and stability were less than 15%. Plasma concentrations of glycyrrhizin, isoliquiritigenin, liquiritigenin, and liquiritin were quantified for 24 h after a single oral administration of 1 g/kg GRE to four rats. Among the four components, plasma concentration of glycyrrhizin was the highest and exhibited a long half-life (23.1 ± 15.5 h). Interestingly, plasma concentrations of isoliquiritigenin and liquiritigenin were restored to the initial concentration at 4–10 h after the GRE administration, as evidenced by liquiritin biotransformation into isoliquiritigenin and liquiritigenin, catalyzed by fecal lysate and gut wall enzymes. In conclusion, our analytical method developed for detecting glycyrrhizin, isoliquiritigenin, liquiritigenin, and liquiritin could be successfully applied to investigate their pharmacokinetic properties in rats and would be useful for conducting further studies on the efficacy, toxicity, and biopharmaceutics of GREs and their marker components.
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6

Amer, Mohamed, and Mohamed Metwalli. "Topical liquiritin improves melasma." International Journal of Dermatology 39, no. 4 (April 2000): 299–301. http://dx.doi.org/10.1046/j.1365-4362.2000.00943.x.

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7

Guan, Yong-Ge, Jin-Bin Liao, Kun-Yin Li, Yu-Cui Li, Yang Song, Jing Ling, and Zi-Ren Su. "Potential Mechanisms of an Antiadenomyosis Chinese Herbal Formula Shaoyao-Gancao Decoction in Primary Cell Culture Model." Evidence-Based Complementary and Alternative Medicine 2014 (2014): 1–11. http://dx.doi.org/10.1155/2014/982913.

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Background. Shaoyao-Gancao Decoction (SGD), a well-known traditional Chinese medicine prescription, has been widely used to treat adenomyosis, dysmenorrhea, abdominal pain, and inflammation in Asia. However, the mechanism underlying the effectiveness of SGD in the treatment of adenomyosis still remains elusive. The present study aimed to investigate the bioactivity of SGD and its underlying molecular mechanisms using cultured human adenomyosis-derived cells.Methods. Human adenomyosis-derived cells were treated with SGD and its major constituents (paeoniflorin and liquiritin)in vitro. Effects of SGD, paeoniflorin, and liquiritin on cell proliferation and apoptosis were examined by MTT assay and flow cytometry analyses. The effects of SGD, paeoniflorin, and liquiritin on the production of PGE2and PGF2αwere assayed using ELISA. ER-αand OTR mRNA expression levels were also evaluated by real-time qRT-PCR.Results. SGD, paeoniflorin, and liquiritin inhibited proliferation and induced apoptosis of human adenomyosis-derived cells in a dose-dependent manner. SGD and paeoniflorin significantly reduced the PGE2and PGF2αproduction. Furthermore, they remarkably decreased the mRNA levels of ER-αand OTR.Conclusions. The results of this study provide possible mechanisms for the bioactivity of SGD for treating adenomyosis and contribute to the ethnopharmacological knowledge about this prescription.
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8

Wang, Hao, Hu Shan, and Haitao Lü. "Preparative Separation and Purification of Liquiritin and Glycyrrhizic Acid from Glycyrrhiza uralensis Fisch by High-Speed Countercurrent Chromatography." Journal of Chromatographic Science 58, no. 9 (August 31, 2020): 823–30. http://dx.doi.org/10.1093/chromsci/bmaa050.

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Abstract The technique of high-speed countercurrent chromatography (HSCCC) was applied to the preparative isolation and purification of liquiritin and glycyrrhizic acid from a crude extract of Glycyrrhiza uralensis Fisch for the first time. Using single factor and orthogonal design experiments, the best extraction conditions were 70% ethanol, 1:25 ratio of solid-to-liquid (w/v) and extracted 1.5 h at 80°C. The contents of liquiritin and glycyrrhizic acid in the crude extract were 1.3 and 5.3%, respectively. Using the two-phase solvent system of ethyl acetate–methanol–water (5:2:5, v/v), 6.0 mg liquiritin (the purity was 96.7%, and the recovery was 89.3%), and 20.5 mg glycyrrhizic acid (the purity was 98.9%, and the recovery was 77.1%) were obtained from 500 mg crude extraction by HSCCC, respectively. The retention rate of stationary phase was 51.0%. Their structures were identified by high-performance liquid chromatography, melting points, ultraviolet radiation, Fourier transform infrared (FTIR), Electrospray ionization mass spectrometry (ESI-MS), 1H Nuclear Magnetic Resonance (NMR) and 13C NMR spectra. The scavenging abilities of glycyrrhizic acid to 1,1-diphenyl-2-picrylhydrazyl and hydroxyl free radicals were stronger than those of liquiritin.
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9

Hennemann, H. H. "Akute Intoxikationserscheinungen durch Succus Liquiritiae." Allgemeine Homöopathische Zeitung 200, no. 07 (April 14, 2007): 236–39. http://dx.doi.org/10.1055/s-2006-934726.

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10

Wu, Yin-Ping, Xian-Sheng Meng, Yong-Rui Bao, Shuai Wang, and Ting-Guo Kang. "Simultaneous Quantitative Determination of Nine Active Chemical Compositions in Traditional Chinese Medicine Glycyrrhiza by RP-HPLC with Full-Time Five-Wavelength Fusion Method." American Journal of Chinese Medicine 41, no. 01 (January 2013): 211–19. http://dx.doi.org/10.1142/s0192415x13500158.

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A new, simple, accurate and reliable full-time five-wavelength fusion method for the simultaneous separation and determination of nine active chemical compositions (liquiritin apioside, liquiritin, isoliquiritin apioside, ononin, isoliquiritin, liquiritigenin, calycosin, isoliquiritigenin, Glycyrrhizic acid monoammonium salt) in traditional Chinese medicine Glycyrrhiza was developed using reverse phase high-performance liquid chromatography (RP-HPLC) coupled with a diode-array detector (DAD). The chromatographic separation was performed on an Agilent TC-C18 column with gradient elution using 0.04% methanoic acid (A) and acetonitrile (B) at a flow rate of 1.0 mL min-1 and UV detection at 248 nm, 250 nm, 276 nm, 362 nm, 370 nm. The standard curves were linear over the range of 2.1379–12.8272 μg for liquiritin apioside, 3.9299–23.5794 μg for liquiritin, 1.0432–6.2592 μg for isoliquiritin apioside, 0.8764–5.8584 μg for ononin, 1.0701–6.4205 μg for isoliquiritin, 1.3685–8.2111 μg for liquiritigenin, 0.3927–2.3563 μg for calycosin, 0.2498– 1.4986 μg for isoliquiritigenin, 2.0094–12.0564 μg for Glycyrrhizic acid monoammonium salt, respectively (r2 > 0.9997). The recoveries and relative standard deviation (RSD) varied from 95.09% to 103.54% and 1.09% to 2.36%, respectively. The precision for all the analytes was less than 2.52%. The method indicated good performance in terms of precision, accuracy and linearity. The method enabled the simultaneous determination of nine active chemical compositions for quality control of Glycyrrhiza.
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Dissertations / Theses on the topic "Liquirizia"

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Campisi, Mirko Antonello Rosario. "Chimica, valutazione delle proprietà antiossidanti e delle attività anti-genotossica ed antiinfiammatoria dei fitocomplessi dalla liquirizia (Glycyrrhiza glabra L.)." Doctoral thesis, Università di Catania, 2013. http://hdl.handle.net/10761/1395.

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Da millenni la liquirizia è utilizzata dall uomo come rimedio terapeutico, in particolare in diverse medicine tradizionali. In questo studio da noi effettuato abbiamo che GA (l acido 18-beta glicirretinico) è un potente inibitore della epatotossicità da accumulo di acidi biliari negli epatociti di ratto; è stata inoltre dimostrata la capacità della glicirrizina di inibire la produzione di radicali liberi, che sono una classe di potenti agenti flogogeni, da parte dei granulociti neutrofili. Dai dati esaminati quindi, possiamo concludere affermando che la liquirizia (Glycyrrhiza glabra L.). ed in particolare l acido glicirretinico e la glabridina, che sono i principi attivi più rappresentati della radice, possono essere anche considerati come dei farmaci efficaci nella terapia di svariate patologie.
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Speicher-Brinker, Annette. "Inhaltsstoffe der Süßholzwurzel (Liquiritiae Radix) : Beiträge zur pharmazeutischen Qualität entsprechender Zubereitungen /." [S.l. : s.n.], 1987. http://www.gbv.de/dms/bs/toc/010287620.pdf.

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Otisková, Alena. "Mikroskopie drogy Liquiritiae radix různého původu." Master's thesis, 2010. http://www.nusl.cz/ntk/nusl-279462.

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One of the most widely known species of the genus Glycyrrhiza (Fabaceae) is without doubt Glycyrrhiza glabra. In the Czech Pharmacopoeia 2009 is the drug Liquiritiae radix defined as dried, unpeeled or peeled, whole or cut root and stolons of Glycyrrhiza glabra L. and/or Glycyrrhiza inflata BAT. and/or Glycyrrhiza uralensis FISH. This thesis summarises the latest information about chemical compounds, pharmacological activity and use of some species of the genus Glycrrhiza and focuses on microscopic characterization of the roots and stolons of G. pallidiflora, G. echinata and G. uralensis. There is a description of anatomy of the underground organs in transection, a description of microscopic elements of powdered drugs, a comparison of the amount of clusters of sclerenchymatic fibres, calcium oxalate crystals and of the size of sclerenchymatic fibres, clusters of sclerenchymatic fibres, calcium oxalate crystals and vessels among these three species. The microscopic description is attended by microphotos. By the comparision of the anatomical structure of roots and stolons in transection among the observed species, some differences were found in the size ratio of bark and wood, in the size and location of clusters of sclerenchymatic fibres, in the amount of calcium oxalate crystals, in the location of...
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Books on the topic "Liquirizia"

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Bettinelli, Giorgio. Pesciolini di liquirizia. Roma: Il Ventaglio, 1991.

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Di viole e liquirizia. Torino: Einaudi, 2005.

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Bettinelli, Giorgio. Pesciolini di liquirizia: Con una nota di Maria Rita Parsi. Roma: Il Ventaglio, 1991.

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Book chapters on the topic "Liquirizia"

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"Liquiritin." In Natural Compounds, 296. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4614-0535-1_673.

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"Liquiritin-4′-O-β-D-apiofuranoside-geptaacetate." In Natural Compounds, 316. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4614-0535-1_713.

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Conference papers on the topic "Liquirizia"

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Liu, Boyan, Juan Chen, and Cuiying Dong. "Optimization of ultrasonic extraction of liquiritin by response surface methodology." In 2017 Chinese Automation Congress (CAC). IEEE, 2017. http://dx.doi.org/10.1109/cac.2017.8243806.

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Yu-hong, Yu, Cai Jian-jun, Dai Rong-ji, Deng Yu-lin, Yang Kun, and Meng Wei-wei. "Seperation and Determination of Glycyrrhizic acid and Liquiritin in Licorice using SPE-RP-HPLC." In 2007 IEEE/ICME International Conference on Complex Medical Engineering. IEEE, 2007. http://dx.doi.org/10.1109/iccme.2007.4382069.

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Li, Fen-fen, Xin-wei Dong, Guan Yan, and Qiang-min Xie. "Effects Of Licorice Flavonoids And Liquiritin Apioside On Cigarette Smoke Extract Induced Cell Toxicity, IL-8 And MUC5AC MRNA Expression In The Human Small Airway Epithelial Cell NCI-H292." In American Thoracic Society 2010 International Conference, May 14-19, 2010 • New Orleans. American Thoracic Society, 2010. http://dx.doi.org/10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a4964.

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Journal articles
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