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Journal articles on the topic 'Lithium'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Andrusyshyna, Iryna, and Sergey Vasilyuk. "ECOLOGICAL AND HYGIENIC MONITORING OF LITHIUM IN WATERS FOR VARIOUS PURPOSES IN UKRAINE AND APPROACHES TO POST-TREATMENT." WATER AND WATER PURIFICATION TECHNOLOGIES. SCIENTIFIC AND TECHNICAL NEWS 39, no. 2 (2024): 36–47. https://doi.org/10.20535/2218-930022024320179.

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The technological revolution is transforming global demand for resources, shifting the focus from traditional energy sources like oil and gas to metals such as lithium, cobalt, and nickel. Lithium, now dubbed "white oil", is critical for powering devices and vehicles, as lithium-ion batteries are foundational in consumer electronics and electric vehicles. Historically, lithium's primary application was in the glass and ceramics industries, with secondary uses in optics and electronics. However, demand has increased substantially in recent years due to advancements in energy storage technology.

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Goldfuss, Bernd, and Frank Eisenträger. "Chiral ligand induced distortions: the origin of pyramidal three-coordinated lithium ions in the X-ray crystal structure of Lithium (1R,2R,4S)-exo- 2-[o-(dimethylaminomethyl)phenyl]-1,3,3-trimethylbicyclo[2.2.1]heptan-endo-2-olate." Australian Journal of Chemistry 53, no. 3 (2000): 209. http://dx.doi.org/10.1071/ch99184.

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The X-ray crystal structure of dimeric lithium (1R,2R,4S)-exo-2-[o-(dimethylaminomethyl)phenyl]-1,3,3-trimethylbicyclo[2.2.1]heptan-endo-2-olate (2-Li)2 exhibits lithium ions with pyramidal environments of oxygen and nitrogen atoms. Ab initio (RHF/6-31+G*) computations of dimeric trimethylamine-coordinated lithium methoxide show that electrostatics disfavour the pyramidal distortions at lithiums in (2-Li)2 by 5.0 kJ/mol. ONIOM(B3LYP/6-31+G*:UFF) computations of (2-Li)2 as well as of (2-Li-b)2 and (2-Li-c)2, with one or two planar constrained lithium ion environments, reveal destabilizations of

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Mifsud, Simon, Kyle Cilia, Emma L. Mifsud, and Mark Gruppetta. "Lithium-associated hyperparathyroidism." British Journal of Hospital Medicine 81, no. 11 (2020): 1–9. http://dx.doi.org/10.12968/hmed.2020.0457.

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Lithium is a mood stabiliser widely used in the treatment and prophylaxis of mania, bipolar disorders and recurrent depression. Treatment with lithium can give rise to various endocrine and metabolic abnormalities, including thyroid dysfunction, nephrogenic diabetes insipidus and hypercalcaemia. Lithium may induce hypercalcaemia through both acute and chronic effects. The initial acute effects are potentially reversible and occur as a result of lithium's action on the calcium-sensing receptor pathway and glycogen synthase kinase 3, giving rise to a biochemical picture similar to that seen in f

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Kavanagh, Laurence, Jerome Keohane, Guiomar Garcia Cabellos, Andrew Lloyd, and John Cleary. "Global Lithium Sources—Industrial Use and Future in the Electric Vehicle Industry: A Review." Resources 7, no. 3 (2018): 57. http://dx.doi.org/10.3390/resources7030057.

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Lithium is a key component in green energy storage technologies and is rapidly becoming a metal of crucial importance to the European Union. The different industrial uses of lithium are discussed in this review along with a compilation of the locations of the main geological sources of lithium. An emphasis is placed on lithium’s use in lithium ion batteries and their use in the electric vehicle industry. The electric vehicle market is driving new demand for lithium resources. The expected scale-up in this sector will put pressure on current lithium supplies. The European Union has a burgeoning

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Baird-Gunning, Jonathan, Tom Lea-Henry, Lotte C. G. Hoegberg, Sophie Gosselin, and Darren M. Roberts. "Lithium Poisoning." Journal of Intensive Care Medicine 32, no. 4 (2016): 249–63. http://dx.doi.org/10.1177/0885066616651582.

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Lithium is a commonly prescribed treatment for bipolar affective disorder. However, treatment is complicated by lithium’s narrow therapeutic index and the influence of kidney function, both of which increase the risk of toxicity. Therefore, careful attention to dosing, monitoring, and titration is required. The cause of lithium poisoning influences treatment and 3 patterns are described: acute, acute-on-chronic, and chronic. Chronic poisoning is the most common etiology, is usually unintentional, and results from lithium intake exceeding elimination. This is most commonly due to impaired kidne

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Felber, Werner, Michael Bauer, Ute Lewitzka, and Bruno Müller-Oerlinghausen. "Lithium Clinics in Berlin and Dresden: a 50-Year Experience." Pharmacopsychiatry 51, no. 05 (2018): 166–71. http://dx.doi.org/10.1055/a-0633-3450.

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AbstractAlthough lithium’s serendipitous discovery as a medication for depression dates back more than 200 years, the first scientific evidence that it prevents mania and depression arose only in the 1960s. However, at that time there was a lack of knowledge about how to administer and monitor lithium therapy safely and properly. The lithium clinics in Dresden and Berlin were remarkably similar in their beginnings in the late 1960s regarding patient numbers and scientific expertise without being aware of one another due to the Iron Curtain separating Germany into a western and eastern part unt

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7

Damri, Odeya, and Galila Agam. "Lithium, Inflammation and Neuroinflammation with Emphasis on Bipolar Disorder—A Narrative Review." International Journal of Molecular Sciences 25, no. 24 (2024): 13277. https://doi.org/10.3390/ijms252413277.

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This narrative review examines lithium’s effects on immune function, inflammation and cell survival, particularly in bipolar disorder (BD) in in vitro studies, animal models and clinical studies. In vitro studies show that high lithium concentrations (5 mM, beyond the therapeutic window) reduce interleukin (IL)-1β production in monocytes and enhance T-lymphocyte resistance, suggesting a protective role against cell death. Lithium modulates oxidative stress in lipopolysaccharide (LPS)-activated macrophages by inhibiting nuclear factor (NF)-ƙB activity and reducing nitric oxide production. At th

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Vecera, Courtney M., Gabriel R. Fries, Lokesh R. Shahani, Jair C. Soares, and Rodrigo Machado-Vieira. "Pharmacogenomics of Lithium Response in Bipolar Disorder." Pharmaceuticals 14, no. 4 (2021): 287. http://dx.doi.org/10.3390/ph14040287.

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Despite being the most widely studied mood stabilizer, researchers have not confirmed a mechanism for lithium’s therapeutic efficacy in Bipolar Disorder (BD). Pharmacogenomic applications may be clinically useful in the future for identifying lithium-responsive patients and facilitating personalized treatment. Six genome-wide association studies (GWAS) reviewed here present evidence of genetic variations related to lithium responsivity and side effect expression. Variants were found on genes regulating the glutamate system, including GAD-like gene 1 (GADL1) and GRIA2 gene, a mutually-regulated

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Almeida, Pedro Amadeu, Filipa Caldas, Inês Homem de Melo, Ana Maria Moreira, and Gustavo França Santos. "Premature Ejaculation after Lithium Treatment in a Patient with Bipolar Disorder." Case Reports in Psychiatry 2023 (January 9, 2023): 1–4. http://dx.doi.org/10.1155/2023/6156023.

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Lithium has proven its efficacy in treating bipolar disorder. Severe side effects caused by lithium, including renal and endocrine outcomes, have already been amply documented. The impact of lithium on sexual function, however, is less well known. A 33-year-old man, with no past medical history, diagnosed with bipolar disorder, developed premature ejaculation after short-term use of lithium. The dose of lithium was reduced, leading to a rapid clinical resolution. Retrospectively, lithium-induced premature ejaculation was deemed the most likely diagnosis. Premature ejaculation is a rare side ef

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Leite, R. Almeida, M. Almeida, J. Borges, and A. Costa. "Lithium in severe affective disorders: Balancing safety with efficacy." European Psychiatry 64, S1 (2021): S778. http://dx.doi.org/10.1192/j.eurpsy.2021.2060.

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IntroductionLithium has been one of the oldest substances used in psychiatric treatments and remains the first-line treatment for prevention of manic and depressive episodes of bipolar disorder (BD), but it has also a wide spectrum of side-effects.ObjectivesThe goal is to review efficacy, and clinical use of lithium, such as its side effects, and its benefit-to-risk ratio.MethodsNon-systematic literature review based on scientific databases such as PubMed.ResultsThe first modern use of lithium was for the treatment of mania. Lithium has also proven useful in major depression, particularly for

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Becchetti, A., and M. Whitaker. "Lithium blocks cell cycle transitions in the first cell cycles of sea urchin embryos, an effect rescued by myo-inositol." Development 124, no. 6 (1997): 1099–107. http://dx.doi.org/10.1242/dev.124.6.1099.

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Lithium is a classical inhibitor of the phosphoinositide pathway and is teratogenic. We report the effects of lithium on the first cell cycles of sea urchin (Lytechinus pictus) embryos. Embryos cultured in 400 mM lithium chloride sea water showed marked delay to the cell cycle and a tendency to arrest prior to nuclear envelope breakdown, at metaphase and at cytokinesis. After removal of lithium, the block was reversed and embryos developed to form normal late blastulae. The lithium-induced block was also reversed by myo- but not epi-inositol, indicating that lithium was acting via the phosphoi

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Lima, Thiago Zaqueu, Miriam Marcela Blanco, Jair Guilherme dos Santos Júnior, Carolina Tesone Coelho, and Luiz Eugênio Mello. "Staying at the crossroads: assessment of the potential of serum lithium monitoring in predicting an ideal lithium dose." Revista Brasileira de Psiquiatria 30, no. 3 (2008): 215–21. http://dx.doi.org/10.1590/s1516-44462008000300007.

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OBJECTIVE: Lithium has been successfully employed to treat bipolar disorder for decades, and recently, was shown to attenuate the symptoms of other pathologies such as Alzheimer's disease, Down's syndrome, ischemic processes, and glutamate-mediated excitotoxicity. However, lithium's narrow therapeutic range limits its broader use. Therefore, the development of methods to better predict its dose becomes essential to an ideal therapy. METHOD: the performance of adult Wistar rats was evaluated at the open field and elevated plus maze after a six weeks treatment with chow supplemented with 0.255%,

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Tobe, Brian T. D., Andrew M. Crain, Alicia M. Winquist, et al. "Probing the lithium-response pathway in hiPSCs implicates the phosphoregulatory set-point for a cytoskeletal modulator in bipolar pathogenesis." Proceedings of the National Academy of Sciences 114, no. 22 (2017): E4462—E4471. http://dx.doi.org/10.1073/pnas.1700111114.

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The molecular pathogenesis of bipolar disorder (BPD) is poorly understood. Using human-induced pluripotent stem cells (hiPSCs) to unravel such mechanisms in polygenic diseases is generally challenging. However, hiPSCs from BPD patients responsive to lithium offered unique opportunities to discern lithium's target and hence gain molecular insight into BPD. By profiling the proteomics of BDP–hiPSC-derived neurons, we found that lithium alters the phosphorylation state of collapsin response mediator protein-2 (CRMP2). Active nonphosphorylated CRMP2, which binds cytoskeleton, is present throughout

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14

Sakrajda, Kosma, and Janusz K. Rybakowski. "The Mechanisms of Lithium Action: The Old and New Findings." Pharmaceuticals 18, no. 4 (2025): 467. https://doi.org/10.3390/ph18040467.

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Despite lithium’s presence in modern psychiatry for three-quarters of a century, the mechanisms of its therapeutic action have not been fully elucidated. This article presents the evolution of the views on these mechanisms, and both the old and new findings are discussed. Among the old mechanisms, lithium’s effect on the purinergic system; electrolyte metabolism; membrane transport; and second messenger systems, namely, cyclic nucleotide and phosphatidylinositol (PI), glycogen synthase kinase-3beta (GSK-3β), brain-derived neurotrophic factor, and neurotransmitters, are discussed. The new data

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15

Papiol, Sergi, Thomas Schulze, and Martin Alda. "Genetics of Lithium Response in Bipolar Disorder." Pharmacopsychiatry 51, no. 05 (2018): 206–11. http://dx.doi.org/10.1055/a-0590-4992.

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Abstract Introduction Lithium remains the best-established long-term treatment for bipolar disorder because of its efficacy in maintaining periods of remission and reducing the risk of suicide. Not all patients successfully respond to lithium treatment, and the individual response, including the occurrence of side effects, is highly variable and not easy to predict. The genetic basis of lithium response is supported by the fact that the response clusters in families. Likewise, recent high-throughput genomic analyses have shed light on its genetic architecture. Methods This nonsystematic review

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Jose, Subin Antony, Jonathan Luke Stoll, Tyson Smith, et al. "Critical Review of Lithium Recovery Methods: Advancements, Challenges, and Future Directions." Processes 12, no. 10 (2024): 2203. http://dx.doi.org/10.3390/pr12102203.

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The integration of lithium into technological applications has profoundly influenced human development, particularly in energy storage systems like lithium-ion batteries. With global demand for lithium surging alongside technological advancements, the sustainable extraction and recovery of this critical material have become increasingly vital. This paper explores lithium’s role, its chemical properties, and the environmental and economic considerations associated with its extraction and recovery. We examine various lithium recovery methods, including conventional techniques such as hydrometall

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17

Rowe, Michael K., and De-Maw Chuang. "Lithium neuroprotection: molecular mechanisms and clinical implications." Expert Reviews in Molecular Medicine 6, no. 21 (2004): 1–18. http://dx.doi.org/10.1017/s1462399404008385.

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Lithium has emerged as a neuroprotective agent efficacious in preventing apoptosis-dependent cellular death. Lithium neuroprotection is provided through multiple, intersecting mechanisms, although how lithium interacts with these mechanisms is still under investigation. Lithium increases cell survival by inducing brain-derived neurotrophic factor and thereby stimulating activity in anti-apoptotic pathways, including the phosphatidylinositol 3-kinase/Akt and the mitogen-activated protein kinase pathways. In addition, lithium reduces pro-apoptotic function by directly and indirectly inhibiting g

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JZ Yin, Alice Shi, Haoyu Yin, Kuinuan Li, and Yuhong Chao. "Global lithium product applications, mineral resources, markets and related issues." Naturalis Scientias 01, no. 03 (2024): 197–217. https://doi.org/10.62252/nss.2024.1015.

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Lithium's natural genes, namely its chemical properties, determine its irreplaceable and important role in many fields of modern society, and also determine why it has become one of the hottest green energy metals today and is inseparable from our daily lives. Therefore, lithium deposits and lithium products have become one of the most concerned resources in the world in the past decade, and have also become a hot spot for investment in the international market. During this period, although the price of lithium products has occasionally fluctuated, it has generally been on the rise. Many visio

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Gayathri, N., A. Ram Sailesh, and N. Srinivas. "Effect of lithium on seed germination and plant growth of Amaranthus viridis." Journal of Applied and Natural Science 14, no. 1 (2022): 133–39. http://dx.doi.org/10.31018/jans.v14i1.3165.

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Lithium is one of the trace elements essential for the human body. The use of Li-based products has increased tremendously, leading to higher consumption patterns and the generation of lithum-based wastes. A higher concentration of lithium leads to the contamination of soil and water bodies. Lithium enters the food chain through the plant pathway. The food chain becomes contaminated with agricultural products produced on lithium-contaminated soil. Owing to this scenario, the present study is focused on studying the effect of lithium on the germination and growth of Amaranthus viridis. Germinat

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Yang, Chunhao, Bo Zhu, Mingjie Zhan, and Zi-Chun Hua. "Lithium in Cancer Therapy: Friend or Foe?" Cancers 15, no. 4 (2023): 1095. http://dx.doi.org/10.3390/cancers15041095.

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Lithium, a trace element important for fetal health and development, is considered a metal drug with a well-established clinical regime, economical production process, and a mature storage system. Several studies have shown that lithium affects tumor development by regulating inositol monophosphate (IMPase) and glycogen synthase kinase-3 (GSK-3). Lithium can also promote proliferation and programmed cell death (PCD) in tumor cells through a number of new targets, such as the nuclear receptor NR4A1 and Hedgehog-Gli. Lithium may increase cancer treatment efficacy while reducing side effects, sug

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Guscott, R., and L. Taylor. "Lithium Prophylaxis in Recurrent Affective Illness." British Journal of Psychiatry 164, no. 6 (1994): 741–46. http://dx.doi.org/10.1192/bjp.164.6.741.

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The efficacy of lithium prophylaxis for recurrent mood disorders is well established. Despite concern that the later efficacy studies have shown poorer results, these studies (after 1980) are equally confirmatory of lithium's efficacy. However, questions have been raised with regards to the effectiveness of lithium prophylaxis under ‘ordinary’ clinical conditions. Part of the confusion stems from the failure to distinguish clearly efficacy (the potential of a treatment) from effectiveness (the results obtained under clinical conditions). Studies of effectiveness or naturalistic studies show po

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Severus, Emanuel, Michael Bauer, and John Geddes. "Efficacy and Effectiveness of Lithium in the Long-Term Treatment of Bipolar Disorders: An Update 2018." Pharmacopsychiatry 51, no. 05 (2018): 173–76. http://dx.doi.org/10.1055/a-0627-7489.

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AbstractFor more than 40 years, lithium has been the gold standard in the long-term treatment of bipolar disorders. In the course of the last 15 years, other drugs have been approved in this indication and are widely used in clinical practice at the expense of lithium. New research from the last few years, however, indicates that lithium is still the first-line treatment in this indication. Against this background and lithium’s proven acute antimanic efficacy, we should perhaps be using lithium more regularly (in combination with an atypical antipsychotic, if necessary) right from the start fo

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Grof, P., M. Alda, E. Grof, D. Fox, and P. Cameron. "The Challenge of Predicting Response to Stabilising Lithium Treatment." British Journal of Psychiatry 163, S21 (1993): 16–19. http://dx.doi.org/10.1192/s000712500029243x.

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Lithium treatment, an approach with well documented efficacy, has recently been losing its treatment value. Lithium continues working, however, for those patients for whom it was proven efficacious; that is, most patients with primary episodic affective disorders. Such responders to lithium prophylaxis can be reliably identified beforehand by a comprehensive clinical assessment. The explanation for the paradox of lithium's lost efficacy lies mostly in the educational bias against a comprehensive patient assessment, and in the shift in diagnostic fashion favouring affective disorders and the tr

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Lodders, Katharina. "The Cosmic Lithium Story." Elements 16, no. 4 (2020): 241–46. http://dx.doi.org/10.2138/gselements.16.4.241.

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Lithium’s story spans the history of the universe and is one that links to all its largest-scale processes: big bang nucleosyntheses, the evolution of stars, and galactic chemical evolution. Lithium was the only metal produced in the big bang, alongside the gases H and He. Stars destroy both stable isotopes of Li easily, yet we still have Li today, even after generations of stars have come and gone. Ongoing production of Li by galactic cosmic rays and by a limited number of Li-producing nuclear reactions and transport processes in some rare types of stars keeps lithium present in the universe.

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Ravan, Jayaprakash Russell, Jigyansa Ipsita Pattnaik, Udit Kumar Panda, Swayanka Samantaray, and Bhumika Mishra. "Lithium’s renaissance: From psychiatric staple to multifaceted medical marvel." Journal of Integrative Medicine and Research 2, no. 4 (2024): 219–28. http://dx.doi.org/10.4103/jimr.jimr_52_24.

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Abstract: Lithium, long established as a cornerstone in the treatment of bipolar disorder, has recently emerged as a potential therapeutic agent across a broad spectrum of medical fields. This narrative review examines the expanding role of lithium in contemporary medicine, highlighting its transition from a psychiatric staple to a versatile therapeutic tool. The objective of the study was to synthesize and critically evaluate recent literature on lithium’s applications beyond psychiatry, focusing on its mechanisms of action, therapeutic potential, and challenges in various medical domains. A

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Tondo, Leonardo, and Ross J. Baldessarini. "History of Suicide Prevention with Lithium Treatment." Pharmaceuticals 18, no. 2 (2025): 258. https://doi.org/10.3390/ph18020258.

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Suicidal behavior is prevalent among individuals with psychiatric illnesses, especially mood, substance abuse, and psychotic disorders. Over the past several decades, lithium treatment in patients with mood disorders has been increasingly used to lower the risk of suicidal behavior. This overview considers that lithium treatment has the most abundant evidence of reducing suicidal behavior. It also examines the hypothesis that higher natural lithium levels in drinking water correlate with reduced suicide rates. We report findings from trials comparing lithium treatment with its absence, placebo

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Moalla, M., A. Larnaout, D. Skhiri, R. Lansari, N. Staali, and W. Melki. "Role of nurses in the initiation and the monitoring of Lithium." European Psychiatry 65, S1 (2022): S177—S178. http://dx.doi.org/10.1192/j.eurpsy.2022.470.

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Introduction Lithium is the oldest known treatment of bipolar disorders and remains the gold standard. Nevertheless, it remains difficult to handle, largely due to its narrow therapeutic index and its long-term side effects. Thus, it requires special initiation and monitoring measures. Objectives This study aims to assess nurses’ knowledge and attitudes regarding lithium. A protocol on Lithium initiation and monitoring will be established. Methods This is a descriptive study including 20 nurses in a psychiatry department conducted from January to May 2021 based on an self-assessment questionna

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Carmassi, Claudia, Benedetta Nardi, Simone Battaglini, et al. "A Case of Lithium Encephalopathy with Therapeutic Lithium Levels: The Diagnostic Role of EEG." Case Reports in Psychiatry 2022 (December 16, 2022): 1–5. http://dx.doi.org/10.1155/2022/8052471.

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Introduction. Lithium is considered a first-line therapy for both the acute phase and the maintenance of bipolar disorder. Many studies highlighted its neuroprotective and neuroplastic capacity suggesting a potential usefulness in the treatment of neurodegenerative diseases. Despite the undeniable efficacy, lithium clearly presents several adverse effects including neurotoxicity, also known as lithium encephalopathy, regarding both neurological, psychiatric, and cognitive side effects. In this case, adverse reactions are not always related to its serum levels, possibly appearing within the the

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Fürnsinn, C., C. Noe, R. Herdlicka, et al. "More marked stimulation by lithium than insulin of the glycogenic pathway in rat skeletal muscle." American Journal of Physiology-Endocrinology and Metabolism 273, no. 3 (1997): E514. http://dx.doi.org/10.1152/ajpendo.1997.273.3.e514.

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Lithium's impact on glucose metabolism was compared with that of insulin in isolated rat soleus muscle. Lithium chloride (20 mmol/l) induced a 4.8-fold more pronounced increment over basal glycogen synthase activity than insulin (10 nmol/l) (nmol UDP-glucose into glycogen in synthase activity assay.g-1.min-1: lithium, +22.1 +/- 1.8 vs. insulin, +4.6 +/- 3.9; P < 0.01). In parallel, lithium was less efficient than insulin in stimulating glucose transport (counts per minute 2-deoxy-D-[3H]glucose.mg-1.h-1: lithium, +211 +/- 19 vs. insulin, +311 +/- 57; P < 0.05) and lactate release (mumol.g

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Post, Robert M., and Janusz K. Rybakowski. "What Patients with Bipolar Disorder Need to Know about Lithium." Pharmaceuticals 17, no. 9 (2024): 1223. http://dx.doi.org/10.3390/ph17091223.

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Lithium is the superior first-line treatment for bipolar disorder (BD). Yet the percentage of patients receiving lithium is abysmally low, especially in the US. Since psychiatrists have failed to place lithium in its appropriate role, we make the case that patients with BD themselves need to be better educated about the unique characteristics and pre-eminence of the drug so that it can be used more often and appropriately. Lithium has a highly unfavorable popular reputation among would-be patients and many psychiatrists. Thus, a direct appeal to patients with BD appears appropriate to try to r

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Hamm, Carlo, Robert Queissner, Rene Pilz, et al. "Zusammenhang zwischen der Einnahme von Lithium und neuroradiologischen Veränderungen bei der bipolar affektiven Störung: Gibt es Hinweise auf ein klinisches Ansprechen?" Fortschritte der Neurologie · Psychiatrie 87, no. 09 (2018): 483–91. http://dx.doi.org/10.1055/a-0637-1820.

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ZusammenfassungZur Vermeidung affektiver Krankheitsphasen im Rahmen der bipolar affektiven Störung erfolgt die psychopharmakologische Behandlung mittels sogenannter Phasenprophylaktika. Traditionell werden unter diesem Begriff die Wirkstoffe Lithium, Valproat, Lamotrigin und Carbamazepin zusammengefasst. Moderne Therapiekonzepte zur Phasenprophylaxe berücksichtigen ebenfalls Antipsychotika der zweiten Generation. In dieser Literaturrecherche sollen die Zusammenhänge zwischen den biologischen Veränderungen des Gehirns und der Einnahme von Lithium dargestellt werden. Hierbei werden Daten aus mak

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Hammond, WP, ER Rodger, and DC Dale. "Lithium augments GM-CSA generation in canine cyclic hematopoiesis." Blood 69, no. 1 (1987): 117–23. http://dx.doi.org/10.1182/blood.v69.1.117.bloodjournal691117.

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Cyclic hematopoiesis in gray collie dogs can be cured by lithium treatment. We examined the mechanism of lithium's effect by developing an assay for the canine equivalent of GM-CSF (called GM-CSA). Phytohemagglutinin (PHA)-stimulated canine blood mononuclear cells produce GM-CSA in a dose-dependent manner; this GM-CSA stimulates more neutrophil-containing colonies than does endotoxin-treated dog serum. Production of GM-CSA by PHA-stimulated normal dog cells was not altered by lithium. However, cells from gray collies during their neutrophilic period increased their GM-CSA when lithium (2 mEq/L

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Fatemi, S. Hossein, Teri J. Reutiman, and Timothy D. Folsom. "The role of lithium in modulation of brain genes: relevance for aetiology and treatment of bipolar disorder." Biochemical Society Transactions 37, no. 5 (2009): 1090–95. http://dx.doi.org/10.1042/bst0371090.

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Bipolar disorder is a debilitating disorder of the brain with a lifetime prevalence of 1.0% for bipolar I, 1.1% for bipolar II disorder and 2.4–4.7% for subthreshold bipolar disorder. Medications, including lithium, have demonstrated efficacy in the treatment of bipolar disorder, but their molecular targets and mode of action are largely unknown. A few studies have begun to shed light on potential targets of lithium treatment that may be involved in lithium's therapeutic effect. We have recently conducted a microarray study of rat frontal cortex following chronic treatment (21 days) with lithi

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Fu, Kun (Kelvin), Yunhui Gong, Jiaqi Dai, et al. "Flexible, solid-state, ion-conducting membrane with 3D garnet nanofiber networks for lithium batteries." Proceedings of the National Academy of Sciences 113, no. 26 (2016): 7094–99. http://dx.doi.org/10.1073/pnas.1600422113.

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Beyond state-of-the-art lithium-ion battery (LIB) technology with metallic lithium anodes to replace conventional ion intercalation anode materials is highly desirable because of lithium’s highest specific capacity (3,860 mA/g) and lowest negative electrochemical potential (∼3.040 V vs. the standard hydrogen electrode). In this work, we report for the first time, to our knowledge, a 3D lithium-ion–conducting ceramic network based on garnet-type Li6.4La3Zr2Al0.2O12 (LLZO) lithium-ion conductor to provide continuous Li+ transfer channels in a polyethylene oxide (PEO)-based composite. This compos

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Hammond, WP, ER Rodger, and DC Dale. "Lithium augments GM-CSA generation in canine cyclic hematopoiesis." Blood 69, no. 1 (1987): 117–23. http://dx.doi.org/10.1182/blood.v69.1.117.117.

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Abstract Cyclic hematopoiesis in gray collie dogs can be cured by lithium treatment. We examined the mechanism of lithium's effect by developing an assay for the canine equivalent of GM-CSF (called GM-CSA). Phytohemagglutinin (PHA)-stimulated canine blood mononuclear cells produce GM-CSA in a dose-dependent manner; this GM-CSA stimulates more neutrophil-containing colonies than does endotoxin-treated dog serum. Production of GM-CSA by PHA-stimulated normal dog cells was not altered by lithium. However, cells from gray collies during their neutrophilic period increased their GM-CSA when lithium

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Agam, Galila, Yuly Bersudsky, Gerard T. Berry, Diederik Moechars, Yael Lavi-Avnon, and R. H. Belmaker. "Knockout mice in understanding the mechanism of action of lithium." Biochemical Society Transactions 37, no. 5 (2009): 1121–25. http://dx.doi.org/10.1042/bst0371121.

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Lithium inhibits IMPase (inositol monophosphatase) activity, as well as inositol transporter function. To determine whether one or more of these mechanisms might underlie lithium's behavioural effects, we studied Impa1 (encoding IMPase) and Smit1 (sodium–myo-inositol transporter 1)-knockout mice. In brains of adult homozygous Impa1-knockout mice, IMPase activity was found to be decreased; however, inositol levels were not found to be altered. Behavioural analysis indicated decreased immobility in the forced-swim test as well as a strongly increased sensitivity to pilocarpine-induced seizures.

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Shakur, Nayeema, Mubin Tahir, Ramanand Badanapuram, and Sagrika Nag. "Clinical Audit of the Awareness of Safety Guidelines on Lithium Prescribing Within the Acute Hospital- James Cook University Hospital." BJPsych Open 8, S1 (2022): S174. http://dx.doi.org/10.1192/bjo.2022.485.

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AimsLithium is a useful drug and is of particular benefit in patients with chronic mood disorders like bipolar affective disorder and recurrent depression. Lithium requires careful monitoring and dose adjustment for safe use due to its narrow therapeutic index and high potential for toxicity. Monitoring must carry on even when mental health patients taking Lithium are admitted to acute hospital. Therefore, the main aim of this clinical audit was to evaluate the level of awareness of the lithium safety guidance amongst medical staff working within the Acute Hospital, James Cook University Hospi

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Fryou, Noah, Mingjia Li, and Bernard Possidente. "0019 Assessing Genetic Variation for Effects of Lithium on Circadian Clock Period and Mortality in Fruit Flies." SLEEP 46, Supplement_1 (2023): A8—A9. http://dx.doi.org/10.1093/sleep/zsad077.0019.

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Abstract Introduction Lithium is the treatment of choice for bipolar disorder, but the mechanism for its therapeutic effect remains unknown, and it has a low threshold for toxic side-effects. Bipolar disorder is cyclical disorder with periodic onsets of illness including depressive and manic episode that vary in cycle length among patients. One of lithium’s well-documented effects- a lengthened circadian clock period- is intriguing since a circadian system abnormality is a potential explanation for the cyclical nature of bipolar disorder. Fruit flies are an efficient model organism for genetic

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Radanovic, Marcia, Monique Patricio Singulani, Vanessa de Jesus R. De Paula, Leda Leme Talib, and Orestes Vicente Forlenza. "An Overview of the Effects of Lithium on Alzheimer’s Disease: A Historical Perspective." Pharmaceuticals 18, no. 4 (2025): 532. https://doi.org/10.3390/ph18040532.

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Lithium was introduced into psychiatric practice in the late nineteenth century and has since become a standard treatment for severe psychiatric disorders, particularly those characterized by psychotic agitation. It remains the most effective agent for managing acute mania and preventing relapses in bipolar disorder. Despite potential adverse effects, lithium’s use should be carefully considered relative to other treatment options, as these alternatives may present distinct safety and tolerability profiles. The World Health Organization classifies lithium salts as ‘essential’ medications for i

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Sulistiyono, Eko, Sri Harjanto, and Latifa Hanum Lalasari. "Separation of Magnesium and Lithium from Brine Water and Bittern Using Sodium Silicate Precipitation Agent." Resources 11, no. 10 (2022): 89. http://dx.doi.org/10.3390/resources11100089.

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Potential natural resources of lithium in Indonesia from brine water and bittern generally have low lithium and high magnesium levels, which need to be separated before further extraction. This research investigates the separation process of magnesium from brine water and bittern using a sodium silicate solution. The experimental results showed that the magnesium precipitation efficiency using sodium silicate was better in brine water than in bittern. A separation selectivity ratio of magnesium to lithium (Mg/Li) below 1 was obtained in brine water of 0.59 and bittern of 0.11 with the addition

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Prieto, Pilar, Cayetano Hernández-Gómez, Sara Román-Sánchez, et al. "Tailoring the Lithium Concentration in Thin Lithium Ferrite Films Obtained by Dual Ion Beam Sputtering." Nanomaterials 14, no. 14 (2024): 1220. http://dx.doi.org/10.3390/nano14141220.

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Thin films of lithium spinel ferrite, LiFe5O8, have attracted much scientific attention because of their potential for efficient excitation, the manipulation and propagation of spin currents due to their insulating character, high-saturation magnetization, and Curie temperature, as well as their ultra-low damping value. In addition, LiFe5O8 is currently one of the most interesting materials in terms of developing spintronic devices based on the ionic control of magnetism, for which it is crucial to control the lithium’s atomic content. In this work, we demonstrate that dual ion beam sputtering

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Fajardo, Val Andrew, Paul J. LeBlanc, and Val Andrei Fajardo. "Trace lithium in Texas tap water is negatively associated with all-cause mortality and premature death." Applied Physiology, Nutrition, and Metabolism 43, no. 4 (2018): 412–14. http://dx.doi.org/10.1139/apnm-2017-0653.

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Lithium in tap water was previously found to have life-extending effects across 18 Japanese municipalities. Using a larger dataset with several Texas counties, our study shows that lithium concentrations in tap water are negatively associated with all-cause mortality (r = −0.18, p = 0.006, 232 counties) and years of potential life lost (r = −0.22, p = 0.001, 214 counties). Thus, our present findings extend and reinforce lithium’s purported life-prolonging effect in humans.

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Baldassano, Claudia F. "Antidepressant Effect of Mood Stabilizers." CNS Spectrums 8, S12 (2003): 4–5. http://dx.doi.org/10.1017/s1092852900028777.

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Bipolar depression certainly poses the greatest challenge to clinicians treating bipolar patients. Having a widespread disability associated with it, bipolar depression is often chronic, is less responsive to medication treatment, and has a particularly high rate of suicide. There are currently no drugs approved by the Food and Drug Administration for the treatment of bipolar depression, although full trials have been conducted with lithium, the antipsychotic olan-zapine, and the antiepileptic (AED) lamotrigine. Data for the other AEDs are quite limited and not controlled. The American Psychia

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Yildiz, Aysegul. "Phosphoinositide metabolism, lithium and manic depressive illness." Spectroscopy 16, no. 3-4 (2002): 307–16. http://dx.doi.org/10.1155/2002/535201.

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Physiology underlying manic depressive illness and treating effects of its most commonly used remedy – “lithium” is yet to be elucidated. Recent years of psychopharmacology research witnessed sparkling developments in our understanding of the mechanisms underlying lithium’s mood stabilizing effects. Recent data on molecular biology andin vivomagnetic resonance spectroscopy suggest that some of the initial actions of lithium may occur through the inhibition of the enzyme inositol monophosphatase (IMPase) and reduction ofmyo–inositol, which in turn initiate a cascade of events at different level

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&NA;. "Lithium see Carbamazepine/lithium." Reactions Weekly &NA;, no. 297 (1990): 8. http://dx.doi.org/10.2165/00128415-199002970-00040.

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&NA;. "Lithium see Doxepin/lithium." Reactions Weekly &NA;, no. 355 (1991): 9. http://dx.doi.org/10.2165/00128415-199103550-00047.

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&NA;. "Lithium see Antipsychotics/lithium." Reactions Weekly &NA;, no. 360 (1991): 8. http://dx.doi.org/10.2165/00128415-199103600-00043.

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&NA;. "Lithium see Amitriptyline/lithium." Reactions Weekly &NA;, no. 362 (1991): 8. http://dx.doi.org/10.2165/00128415-199103620-00036.

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Lin, Liangdong, Feng Liang, Kaiyuan Zhang, Hongzhi Mao, Jian Yang, and Yitai Qian. "Lithium phosphide/lithium chloride coating on lithium for advanced lithium metal anode." Journal of Materials Chemistry A 6, no. 32 (2018): 15859–67. http://dx.doi.org/10.1039/c8ta05102j.

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Khayachi, Anouar, Ariel Ase, Calwing Liao, et al. "Chronic lithium treatment alters the excitatory/ inhibitory balance of synaptic networks and reduces mGluR5–PKC signalling in mouse cortical neurons." Journal of Psychiatry & Neuroscience 46, no. 3 (2021): E402—E414. http://dx.doi.org/10.1503/jpn.200185.

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Background: Bipolar disorder is characterized by cyclical alternation between mania and depression, often comorbid with psychosis and suicide. Compared with other medications, the mood stabilizer lithium is the most effective treatment for the prevention of manic and depressive episodes. However, the pathophysiology of bipolar disorder and lithium’s mode of action are yet to be fully understood. Evidence suggests a change in the balance of excitatory and inhibitory activity, favouring excitation in bipolar disorder. In the present study, we sought to establish a holistic understanding of the n

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