Log in

Relevant bibliographies by topics / Liver cells Effect of drugs on / Journal articles

To see the other types of publications on this topic, follow the link: Liver cells Effect of drugs on.

Journal articles on the topic 'Liver cells Effect of drugs on'

Author: Grafiati

Published: 4 June 2021

Last updated: 29 January 2023

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'Liver cells Effect of drugs on.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

HATANO, MOTOHISA. "Studies on free liver cells of rats. Effect of various drugs." Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics 18, no. 1 (1987): 87–88. http://dx.doi.org/10.3999/jscpt.18.87.

Full text

APA, Harvard, Vancouver, ISO, and other styles

2

Rashid, M. S., Faheem Hadi, Zoya Muzaffar, H. M. Asif, Naveed Akhtar, Memoona Zahra, Maqbool, L. Sumreen, T. Shamim, and A. Malik. "Cytotoxic Effect of Kigelia Africana Plant Extracts on Liver Cancer Cells." Pakistan Journal of Medical and Health Sciences 16, no. 10 (October 30, 2022): 68–71. http://dx.doi.org/10.53350/pjmhs22161068.

Full text

Abstract:

Background: Various medicinal plants have much efficacious value as treatment of many fatal conditions including cancer. Kigelia africana has known therapeutic efficacy in different ailments and has been used as traditional medicine since ages. Aim: To evaluate anticancer property of any drug or plant extract including HepG2 cell line. Methodology: Anticancer activity of n-hexane and ethanolic extracts of Kigelia africana was checked. IC50 was evaluated via MTT assay, crystal violet assay was performed to check the viability of cells and trypan blue assay to count dead cells. Furthermore, muse

APA, Harvard, Vancouver, ISO, and other styles

3

Ting, Liu, Liu Juan, and Yang Jian Qiong. "Effective Components of Hepatoprotective Drugs." Applied Mechanics and Materials 633-634 (September 2014): 533–36. http://dx.doi.org/10.4028/www.scientific.net/amm.633-634.533.

Full text

Abstract:

Pathological changes in animal models of autoimmune hepatitis and liver cells were similar to the mechanism of injury and viral hepatitis, the thesis of the active component of several common liver substances studied, wild chrysanthemum extract has anti-bacterial, anti-viral, pharmacological effects such as anti-inflammatory and immune liver and nerve protection, Dicliptera polysaccharide with excellent hepatoprotective activity of the liver that can be used as an adjunct to clinical medicine. Introduction

APA, Harvard, Vancouver, ISO, and other styles

4

Li, Rui, Chengyong Dong, Keqiu Jiang, Rui Sun, Yang Zhou, Zeli Yin, Jiaxin Lv, Junlin Zhang, Qi Wang, and Liming Wang. "Rab27B enhances drug resistance in hepatocellular carcinoma by promoting exosome-mediated drug efflux." Carcinogenesis 41, no. 11 (May 11, 2020): 1583–91. http://dx.doi.org/10.1093/carcin/bgaa029.

Full text

Abstract:

Abstract Liver cancer is a major threat to human life and health, and chemotherapy has been the standard non-surgical treatment for liver cancer. However, the emergence of drug resistance of liver cancer cells has hindered the therapeutic effect of chemical drugs. The discovery of exosomes has provided new insights into the mechanisms underlying tumour cell resistance. In this study, we aimed to determine the proteins associated with drug resistance in tumour cells and to elucidate the underlying mechanisms. We found that Rab27B expression in drug (5-fluorouracil, 5Fu)-resistant Bel7402 (Bel/5

APA, Harvard, Vancouver, ISO, and other styles

5

Renovaldi, Dede, and Abdul Khalik Adam. "Potential of Sweet Basil (Ocimum basilicum) as a Hepatoprotector Agent for Liver Injury Related to Drugs." Muhammadiyah Medical Journal 1, no. 2 (November 16, 2020): 63. http://dx.doi.org/10.24853/mmj.1.2.63-68.

Full text

Abstract:

The use of drugs is one of the most common causes of liver injury, because the liver is the main organ that metabolizes drugs. Little is currently done if there is a liver injury due to the hepatotoxic side effects of a drug. Herbal plants have active natural compounds that have pharmacological effects so they are widely used as alternative treatments. Sweet basil (Ocimum basilicum) is one of the most cultivated plants in Asia. Studies on the use of Ocimum basilicum in medicine have been carried out, one of which is the hepatoprotector effect. Studies indicate that Ocimum basilicum is rich in

APA, Harvard, Vancouver, ISO, and other styles

6

Renovaldi, Dede, and Abdul Khalik Adam. "Potential of Sweet Basil (Ocimum basilicum) as a Hepatoprotector Agent for Liver Injury Related to Drugs." Muhammadiyah Medical Journal 1, no. 2 (November 16, 2020): 21. http://dx.doi.org/10.24853/mmj.1.2.21-26.

Full text

Abstract:

The use of drugs is one of the most common causes of liver injury, because the liver is the main organ that metabolizes drugs. Little is currently done if there is a liver injury due to the hepatotoxic side effects of a drug. Herbal plants have active natural compounds that have pharmacological effects so they are widely used as alternative treatments. Sweet basil (Ocimum basilicum) is one of the most cultivated plants in Asia. Studies on the use of Ocimum basilicum in medicine have been carried out, one of which is the hepatoprotector effect. Studies indicate that Ocimum basilicum is rich in

APA, Harvard, Vancouver, ISO, and other styles

7

Liao, Wei, Yan Tang, Zhengcui Hu, Chunyan Wang, Yi Chen, Yi Zhang, and Wenhan Fan. "Preparation of Galactosyl Nanoparticles and Their Targeting Efficiency to Hepatocellular Carcinoma." Journal of Nanoscience and Nanotechnology 21, no. 2 (February 1, 2021): 987–94. http://dx.doi.org/10.1166/jnn.2021.18666.

Full text

Abstract:

Liver diseases seriously endanger people’s physical health, especially liver cancer, and its morbidity and mortality have increased year by year. The reason why liver cancer is difficult to cure is that in addition to the low lethality of cancer drugs to cancer cells, another important factor is that the drugs do not have liver targeting, and there is no way to efficiently deliver anti-cancer drugs to the liver lesions. Hepatocytes can specifically recognize galactose, therefore the galactosyl liver-targeted drug carrier can deliver the drug to the liver in a targeted manner, so that the drug

APA, Harvard, Vancouver, ISO, and other styles

8

ÖNAL, Müge Gülcihan. "A New Approach: Treatment with Sodium Vanadate and Cisplatin Combination for Human Hepatocellular Carcinoma." Proceedings 40, no. 1 (December 25, 2019): 14. http://dx.doi.org/10.3390/proceedings2019040014.

Full text

Abstract:

The most common primary liver malignancy is hepatocellular carcinoma. Various chemotherapy drugs are used for treatment. These drugs have high toxicity to liver tissue. More effective, less toxic options should be preferred for treatment. The aim of this study is to investigate the cytotoxic effect of cisplatin and sodium vanadate combination (NaV) in hepatocellular carcinoma. The hepatocellular cancer cell line (HepG2) was used in this study. Increased concentration of cisplatin and a selected concentration of sodium vanadate were treated to HepG2 cells for 24- and 72-hours incubation times.

APA, Harvard, Vancouver, ISO, and other styles

9

Tian, Shiliu, Rui Su, Ke Wu, Xuhan Zhou, Jaydutt V. Vadgama, and Yong Wu. "Diaporine Potentiates the Anticancer Effects of Oxaliplatin and Doxorubicin on Liver Cancer Cells." Journal of Personalized Medicine 12, no. 8 (August 16, 2022): 1318. http://dx.doi.org/10.3390/jpm12081318.

Full text

Abstract:

Recent studies have shown that diaporine, a novel fungal metabolic product, has a strong in vitro and in vivo anticancer effect on human non-small-cell lung and breast cancers. In this study, three human hepatocarcinoma cell lines (HepG2, Hep3B, and Huh7) were used to evaluate the efficacy of diaporine alone and in combination with the standard cytotoxic drugs oxaliplatin and doxorubicin for the treatment of liver cancer. We demonstrated that diaporine, oxaliplatin, and doxorubicin triggered a concentration- and time-dependent decrease in the number of HepG2 cells. Diaporine at a concentration

APA, Harvard, Vancouver, ISO, and other styles

10

Hatta, Fazleen Haslinda Mohd, Ruhil Nadirah Che Omar, Mohd Ikhwan Ismail, Rosmadi Mohd Yusoff, and Mohd Shihabuddin Ahmad Noorden. "Determining the Population Doubling Time of HepG2 and Huh-7 Cells and the Toxic Effect of Dimethyl Sulfoxide (DMSO)." ASM Science Journal 17 (November 7, 2022): 1–5. http://dx.doi.org/10.32802/asmscj.2022.1238.

Full text

Abstract:

Developing cell lines that carry promising qualities closest to human hepatocytes in drug studies is a dream of many research laboratories. About 90% of drugs are metabolised by the liver. Therefore, most drug discovery studies utilise hepatocytes to understand the basic mechanism of the drug’s breakdown. To assure hepatocytes survival, various solvents were tested for their cytotoxicity on the cell line. Since most drugs are weakly soluble in water, they can be dissolved in an aprotic solvent. To obtain accurate results, the requirements of these solvents are biocompatible and non-toxic to th

APA, Harvard, Vancouver, ISO, and other styles

11

Bian, Xufei, Lan Jiang, Jing Zhou, Xiaoshu Guan, Jingyu Wang, Peng Xiang, Junyi Pan, and Xiangnan Hu. "Improving Dissolution and Cytotoxicity by Forming Multidrug Crystals." Molecules 25, no. 6 (March 16, 2020): 1343. http://dx.doi.org/10.3390/molecules25061343.

Full text

Abstract:

Both rosiglitazone and metformin have effects on blood glucose regulation and the proliferation of liver cancer cells. Combination therapy with these two drugs is common and effective for the treatment of diabetes in the clinic, however, the application of these two drugs is influenced by the poor dissolution of rosiglitazone and the gastrointestinal side-effect of metformin resulting from a high solubility. The formation of a multidrug crystal form (Rsg-Met) by a solvent evaporation method can solve the solubility issue. Crystal structure data and intramolecular hydrogen bonds were detected b

APA, Harvard, Vancouver, ISO, and other styles

12

Sukhanov, D. S., E. D. Bazhanova, and D. L. Teplyi. "ROLE OF HEPATOPROTECTORS AND IMMUNOMODULATORS IN REGULATION OF HEPATOCYTE APOPTOSIS INDUCED BY ANTITUBERCULOSIS TREATMENT." Annals of the Russian academy of medical sciences 68, no. 8 (August 19, 2013): 45–50. http://dx.doi.org/10.15690/vramn.v68i8.723.

Full text

Abstract:

It was currently shown that hepatopathy due to drug toxicity is associated with increased apoptosis of hepatocytes. Therefore, development of drugs which regulate cell death is of great importance. Aim: to involve some hepatoprotectors (ademethionine, reamberin, remaxol) and immunomodulators (cycloferon) into regulation of apoptosis in experimental models of liver first-line antituberculousis drugs (isoniazid, rifampicin, pyrazinamide). Materials and methods: levels of apoptosis (TUNEL), expression of CD95 (receptor of tumor necrosis factor ― by immunohistochemistry), expression of caspase-8,

APA, Harvard, Vancouver, ISO, and other styles

13

Chen, Wenzhuo, Xuefeng Li, Chengfei Liu, Jia He, Miao Qi, Yue Sun, Bingbing Shi та ін. "β-Cyclodextrin modified Pt(II) metallacycle-based supramolecular hyperbranched polymer assemblies for DOX delivery to liver cancer cells". Proceedings of the National Academy of Sciences 117, № 49 (23 листопада 2020): 30942–48. http://dx.doi.org/10.1073/pnas.2007798117.

Full text

Abstract:

Despite the widespread clinical application of chemotherapeutic anticancer drugs, their adverse side effects and inefficient performances remain ongoing issues. A drug delivery system (DDS) designed for a specific cancer may therefore overcome the drawbacks of single chemotherapeutic drugs and provide precise and synergistical cancer treatment by introducing exclusive stimulus responsiveness and combined chemotherapy properties. Herein, we report the design and synthesis of a supramolecular drug delivery assembly 1 constructed by orthogonal self-assembly technique in aqueous media specifically

APA, Harvard, Vancouver, ISO, and other styles

14

Jing, Bolin, Gong Cheng, Jianjun Li, Zhuo A. Wang, and Yuguang Du. "Inhibition of Liver Tumor Cell Metastasis by Partially Acetylated Chitosan Oligosaccharide on A Tumor-Vessel Microsystem." Marine Drugs 17, no. 7 (July 13, 2019): 415. http://dx.doi.org/10.3390/md17070415.

Full text

Abstract:

Chitooligosaccharides (COS), the only cationic oligosaccharide in nature, have been demonstrated to have anti-tumor activity. However, the inhibitory effects of COS on different stages of tumor metastasis are still unknown, and it is not clear what stage(s) of tumor metastasis COS targeted. To study the inhibitory effects of a new partially acetylated chitooligosaccharide (paCOS) with fraction of acetylation (FA) 0.46 on each phase of liver cancer cell metastasis, a dynamic tumor-vessel microsystem undergoing physiological flow was leveraged. paCOS (FA = 0.46) significantly inhibited prolifera

APA, Harvard, Vancouver, ISO, and other styles

15

Medina-Pizaño, Mariana Yazmin, Marina Nayeli Medina-Rosales, Sandra Luz Martínez-Hernández, Liseth Rubi Aldaba-Muruato, José Roberto Macías-Pérez, Esperanza Sánchez-Alemán, Javier Ventura-Juárez, and Martin Humberto Muñoz-Ortega. "Protective Effect of Curcumin against Doxazosin- and Carvedilol-Induced Oxidative Stress in HepG2 Cells." Oxidative Medicine and Cellular Longevity 2022 (February 11, 2022): 1–15. http://dx.doi.org/10.1155/2022/6085515.

Full text

Abstract:

Doxazosin and carvedilol have been evaluated as an alternative treatment against chronic liver lesions and for their possible role during the regeneration of damage caused by liver fibrosis in a hamster model. However, these drugs have been reported to induce morphological changes in hepatocytes, affecting the recovery of liver parenchyma. The effects of these α/𝛽 adrenoblockers on the viability of hepatocytes are unknown. Herein, we demonstrate the protective effect of curcumin against the possible side effects of doxazosin and carvedilol, drugs with proven antifibrotic activity. After pretre

APA, Harvard, Vancouver, ISO, and other styles

16

Yuhas, Yael, Eva Berent, and Shai Ashkenazi. "Effect of Rifampin on Production of Inflammatory Mediators in HepG2 Liver Epithelial Cells." Antimicrobial Agents and Chemotherapy 55, no. 12 (September 19, 2011): 5541–46. http://dx.doi.org/10.1128/aac.05149-11.

Full text

Abstract:

ABSTRACTRifampin, a potent antibacterial agent, is one of the main drugs used in the treatment of mycobacterial infections. Hepatotoxicity is a well-documented adverse event. The aim of this study was to investigate the effect of rifampin on the production of inflammatory mediators in human epithelial HepG2 liver cells in the absence or presence of proinflammatory cytokines. Incubation of HepG2 cells with a cytokine mix plus rifampin was associated with a significant dose-dependent increase in the production of nitric oxide compared to incubation with the cytokine mix alone (P< 0.05) as wel

APA, Harvard, Vancouver, ISO, and other styles

17

Coelho, DR, ACAX De-Oliveira, TEM Parente, BS Leal, LF das Chagas, TN Oliveira, TD Saint’Pierre, and FJR Paumgartten. "In vivo and in vitro effects of pentavalent antimony on mouse liver cytochrome P450s." Human & Experimental Toxicology 36, no. 1 (July 11, 2016): 33–41. http://dx.doi.org/10.1177/0960327116637110.

Full text

Abstract:

Pentavalent antimonial (Sb5+) drugs such as meglumine antimoniate (MA) are the mainstay treatment of leishmaniases in developing countries. The effects of these compounds on drug-metabolizing enzymes have not been characterized and their potential pharmacokinetic interactions with other drugs are therefore unknown. The present study investigated whether treatment with MA (300 mg Sb5+/kg body weight/day, subcutaneously) for 24 days affected the activities of cytochrome P450 (CYP)1A (ethoxyresorufin- O-deethylase), CYP2A5 (coumarin 7-hydroxylase), CYP2E1 ( p-nitrophenol-hydroxylase), CYP2B9/10 (

APA, Harvard, Vancouver, ISO, and other styles

18

Horita, Yasuhiro, and Norio Doi. "Comparative Study of the Effects of Antituberculosis Drugs and Antiretroviral Drugs on Cytochrome P450 3A4 and P-Glycoprotein." Antimicrobial Agents and Chemotherapy 58, no. 6 (March 24, 2014): 3168–76. http://dx.doi.org/10.1128/aac.02278-13.

Full text

Abstract:

ABSTRACTPredicting drug-drug interactions (DDIs) related to cytochrome P450 (CYP), such as CYP3A4 and one of the major drug transporters, P-glycoprotein (P-gp), is crucial in the development of future chemotherapeutic regimens to treat tuberculosis (TB) and TB/AIDS coinfection cases. We evaluated the effects of 30 anti-TB drugs, novel candidates, macrolides, and representative antiretroviral drugs on human CYP3A4 activity using a commercially available screening kit for CYP3A4 inhibitors and a human hepatocyte, HepaRG. Moreover, in order to estimate the interactions of these drugs with human P

APA, Harvard, Vancouver, ISO, and other styles

19

Noguchi, T., H. Fukumoto, Y. Mishina, and M. Obinata. "Differentiation of erythroid progenitor (CFU-E) cells from mouse fetal liver cells and murine erythroleukemia (TSA8) cells without proliferation." Molecular and Cellular Biology 8, no. 6 (June 1988): 2604–9. http://dx.doi.org/10.1128/mcb.8.6.2604-2609.1988.

Full text

Abstract:

Erythropoietin (epo) appears to play a significant role in influencing the proliferation and differentiation of erythroid progenitor (CFU-E) cells. To determine the mechanism of action of epo, the effect of drugs on the in vitro colony formation of CFU-E cells induced from a novel murine erythroleukemia cell line, TSA8, was examined. While cytosine arabinoside inhibited colony formation and terminal differentiation of the CFU-E cells responding to epo, herbimycin, which is a drug that inhibits src-related phosphorylation, inhibited colony formation only. The same effect of herbimycin was obser

APA, Harvard, Vancouver, ISO, and other styles

20

Noguchi, T., H. Fukumoto, Y. Mishina, and M. Obinata. "Differentiation of erythroid progenitor (CFU-E) cells from mouse fetal liver cells and murine erythroleukemia (TSA8) cells without proliferation." Molecular and Cellular Biology 8, no. 6 (June 1988): 2604–9. http://dx.doi.org/10.1128/mcb.8.6.2604.

Full text

Abstract:

Erythropoietin (epo) appears to play a significant role in influencing the proliferation and differentiation of erythroid progenitor (CFU-E) cells. To determine the mechanism of action of epo, the effect of drugs on the in vitro colony formation of CFU-E cells induced from a novel murine erythroleukemia cell line, TSA8, was examined. While cytosine arabinoside inhibited colony formation and terminal differentiation of the CFU-E cells responding to epo, herbimycin, which is a drug that inhibits src-related phosphorylation, inhibited colony formation only. The same effect of herbimycin was obser

APA, Harvard, Vancouver, ISO, and other styles

21

Mo, Jiantao, Xuanbo Da, Qiaoxin Li, Jingjing Huang, Le Lu, and Hongwei Lu. "The Study of Exosomes-Encapsulated mPEG-PLGA Polymer Drug-Loaded Particles for Targeted Therapy of Liver Cancer." Journal of Oncology 2022 (September 17, 2022): 1–10. http://dx.doi.org/10.1155/2022/4234116.

Full text

Abstract:

The emergence of targeted drugs brings hope to patients with advanced liver cancer. However, due to the complex and diverse environment in the human body, the overall response rate of targeted drugs is not high. Therefore, how to efficiently deliver targeted drugs to tumor sites is a major challenge for current research. The project intends to construct mPEG-PLGA nanoparticles loaded with Sora and encapsulate them with exosomes for targeted therapy of hepatocellular carcinoma. mPEG-PLGA drug-loaded nanoparticles were prepared by the dialysis method and characterized by TEM and DLS. The obtaine

APA, Harvard, Vancouver, ISO, and other styles

22

Wang, Meixi, Jianrui Li, Hu Li, Biao Dong, Jing Jiang, Nannan Liu, Jiali Tan, et al. "Down-Regulating the High Level of 17-Beta-Hydroxysteroid Dehydrogenase 13 Plays a Therapeutic Role for Non-Alcoholic Fatty Liver Disease." International Journal of Molecular Sciences 23, no. 10 (May 16, 2022): 5544. http://dx.doi.org/10.3390/ijms23105544.

Full text

Abstract:

Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide, and there is no specific drug to treat it. Recent results showed that 17-beta-hydroxysteroid dehydrogenase type 13 (HSD17B13) is associated with liver diseases, but these conclusions are controversial. Here, we showed that HSD17B13 was more highly expressed in the livers of NAFLD patients, and high expression was induced in the livers of murine NAFLD models and cultural hepatocytes treated using various etiologies. The high HSD17B13 expression in the hepatocytes facilitated the progression of NAFLD by

APA, Harvard, Vancouver, ISO, and other styles

23

Anju, Thangammal, Radhakrishnan Preetha, Raja Shunmugam, Shivshankar R. Mane, Jesu Arockiaraj, and Shivasekar Ganapathy. "Non-Clinical Investigation of Tuberculosis Drugs: Conjugated Norbornene- Based Nanocarriers Toxic Impacts on Zebrafish." Current Nanomedicine 11, no. 4 (December 2021): 224–36. http://dx.doi.org/10.2174/2468187312666211221130125.

Full text

Abstract:

INTRODUCTION: Rifampicin conjugated (R-CP), and rifampicin -isoniazid dual conjugated (RI-CP) norbornene-derived nanocarriers are newly designed for pH stimuli-responsive delivery of tuberculosis (TB) drugs. Its biosafety level is yet to be well established. OBJECTIVES: To assess the impacts of the nanocarriers on liver cells using zebrafish animal model and human liver cell line model (HepG2). METHODS: Initially, lethal dose concentration for the norbornene-derived nanocarrier systems in zebrafish was determined. The toxic effects were analysed at the sub-lethal drug concentration by histopat

APA, Harvard, Vancouver, ISO, and other styles

24

Wu, Yafeng, Run Ma, Cuizhen Long, Yuanhui Shu, Ping He, Yan Zhou, Yining Xiang, and Yuping Wang. "The protective effect of cannabinoid type II receptor agonist AM1241 on ConA-induced liver injury in mice via mitogen-activated protein kinase signalling pathway." International Journal of Immunopathology and Pharmacology 35 (January 2021): 205873842110352. http://dx.doi.org/10.1177/20587384211035251.

Full text

Abstract:

Introduction The endocannabinoid system plays an important role in regulating the immune responses in inflammation. At present, there are no good clinical drugs for many immune liver diseases. Methods We explored the protective effect of the cannabinoid type II (CB2) receptor agonist AM1241 on the liver of mice with acute liver injury caused by concanavalin from the perspective of inflammation and immunity. Pathological evaluation in hepatic tissue was examined by haematoxylin and eosin (HE) staining and the levels of biochemical parameters in the serum were measured by automatic biochemical a

APA, Harvard, Vancouver, ISO, and other styles

25

Ruoß, Marc, Silas Rebholz, Marina Weimer, Carl Grom-Baumgarten, Kiriaki Athanasopulu, Ralf Kemkemer, Hanno Käß, Sabrina Ehnert, and Andreas K. Nussler. "Development of Scaffolds with Adjusted Stiffness for Mimicking Disease-Related Alterations of Liver Rigidity." Journal of Functional Biomaterials 11, no. 1 (March 14, 2020): 17. http://dx.doi.org/10.3390/jfb11010017.

Full text

Abstract:

Drug-induced liver toxicity is one of the most common reasons for the failure of drugs in clinical trials and frequent withdrawal from the market. Reasons for such failures include the low predictive power of in vivo studies, that is mainly caused by metabolic differences between humans and animals, and intraspecific variances. In addition to factors such as age and genetic background, changes in drug metabolism can also be caused by disease-related changes in the liver. Such metabolic changes have also been observed in clinical settings, for example, in association with a change in liver stif

APA, Harvard, Vancouver, ISO, and other styles

26

Irshad, Faiza, Kanwal Saeed, Muhammad Adeel Qama, Jamshad Latif, Zia Ul Mustafa, and Lubaba Mukhtar. "Histological alterations in Rabbit liver after treatment with dexamethasone." Pakistan Journal of Medical and Health Sciences 15, no. 9 (September 30, 2021): 2373–75. http://dx.doi.org/10.53350/pjmhs211592373.

Full text

Abstract:

Background One of the most potent glucocorticoids is known as Dexamethasone. Many metabolic side effect shave been reported on almost every organ after dexamethasone treatment specially its effect on liver. Aim: To investigate harmful side effects of dexamethasone sodium phosphate on rabbit’s liver that serve as human liver model via using light microscope, by administration of two doses (extreme) and two durations in order to depict the duration as well as dosage dependency. Methods: Liver samples were taken via rabbits who were administered dexamethasone sodium phosphate. Then two Stratas we

APA, Harvard, Vancouver, ISO, and other styles

27

Komala M, Sathesh Kumar S, and Padmavathy J. "Novel Drug Formulation for the Treatment of Hepatic Cancer- A Review." International Journal of Research in Pharmaceutical Sciences 11, no. 3 (July 29, 2020): 4395–401. http://dx.doi.org/10.26452/ijrps.v11i3.2658.

Full text

Abstract:

For metabolic transformation, uptake, detoxification, and excretion liver is the primary organ that is highly equipped. Thus, the liver requires targeting by means like a carrier-mediated mechanism to take xenobiotics into the bile, though high hepatic concentration is achieved by most of the drugs. Thus resulting in high first-pass metabolism displayed by the drugs and thus resulting in rapid clearance of the drugs. Uptake of particulate materials is highly contributed by the kupffer cells largely. However, drug uptake by the liver is highly dependent on hepatocytes. In drug delivery, tissue

APA, Harvard, Vancouver, ISO, and other styles

28

Smok, A. M., A. M. Malkova, D. A. Kudlay, and A. A. Starshinova. "Possibilities for correcting hepatotoxic reactions during therapy in patients with COVID-19 (case report)." Translational Medicine 7, no. 6 (December 18, 2020): 65–72. http://dx.doi.org/10.18705/2311-4495-2020-7-6-65-72.

Full text

Abstract:

In 2020, a pandemic of the new coronavirus infection (COVID-19) began. Treatment of this infection is limited by the lack of effective etiological treatment, which requires the selection of empirical and symptomatic therapy. The obtained some effectiveness of the use of antimalarial drugs, antiretroviral drugs in combination with antibacterial therapy made it possible to recommend it for use in the treatment regimen for patients with COVID-19. However, these drugs provoke the development of undesirable side reactions that require correction to continue treatment. Considering the need to use co

APA, Harvard, Vancouver, ISO, and other styles

29

Akın, Bakır, Ökçesiz, and Eken. "Evaluation of Cytotoxic Effects of Carnosic Acid Alone and Combination with Cisplatin in HepG2 Cells." Proceedings 40, no. 1 (December 31, 2019): 39. http://dx.doi.org/10.3390/proceedings2019040039.

Full text

Abstract:

Natural products are important in prevention and treatment of cancer because of their antitumor effect and reducing side effects of chemotherapeutic drugs. The aim of this study was to investigate the potential cytotoxic effecs of carnosic acid and in combination with cisplatin in liver cancer cells. Cytotoxicity was assessed using MTT assay for 24/48 hours. The intracellular ROS levels were determined using the oxidation‐sensitive fluorescent probes DCFH‐DA. Changes in the mitochondrial membrane potential (MMP) were detected using JC-1 commercial kit. Concentrations were selected for carnosic

APA, Harvard, Vancouver, ISO, and other styles

30

Su, Qiang, Wei Kuang, Weiyi Hao, Jing Liang, Liang Wu, Chunmei Tang, Yali Wang, and Tao Liu. "Antituberculosis Drugs (Rifampicin and Isoniazid) Induce Liver Injury by Regulating NLRP3 Inflammasomes." Mediators of Inflammation 2021 (February 19, 2021): 1–13. http://dx.doi.org/10.1155/2021/8086253.

Full text

Abstract:

Patients being treated for pulmonary tuberculosis often suffer liver injury due to the effects of anti-TB drugs, and the underlying mechanisms for those injuries need to be clarified. In this study, rats and hepatic cells were administrated isoniazid (INH) and rifampin (RIF) and then treated with NLRP3-inflammasome inhibitors (INF39 and CP-456773) or NLRP3 siRNA. Histopathological changes that occurred in liver tissue were examined by H&E staining. Additionally, the levels IL-33, IL-18, IL-1β, NLRP3, ASC, and cleaved-caspase 1 expression in the liver tissues were also determined. NAT2 and

APA, Harvard, Vancouver, ISO, and other styles

31

Abolhasani, Ahmad, Fatemeh Heidari, Somayeh Noori, Shokoufeh Mousavi, and Hoda Abolhasani. "Cytotoxicity Evaluation of Dimethoxy and Trimethoxy Indanonic Spiroisoxazolines Against Cancerous Liver Cells." Current Chemical Biology 14, no. 1 (May 26, 2020): 38–47. http://dx.doi.org/10.2174/2212796813666190926112807.

Full text

Abstract:

Background: 3'-(3,4-dimethoxyphenyl)-4'-(4-(methylsulfonyl)phenyl)-4'H-spiro [indene-2,5'-isoxazol]-1(3H)-one and 4'-(4-(methylsulfonyl)phenyl)-3'-(3,4,5-trimethoxyphenyl)- 4'H-spiro[indene-2,5'-isoxazol]-1(3H)-one compounds containing indanonic spiroisoxazoline core are widely known for their antiproliferative activities and investigation of tubulin binding modes. Objective: To evaluate the cytotoxicity effect of Dimethoxy and Trimethoxy Indanonic Spiroisoxazolines against HepG2 cancerous liver cell line and to perform a comparison with other known anti-liver cancer drugs. Methods: The evalua

APA, Harvard, Vancouver, ISO, and other styles

32

ÖZGERMEN, Başak, Orhan YAVUZ, and Ali Evren HAYDARDEDEOĞLU. "Investigation of the effects of mesenchymal stem cell administration on liver recovery in experimental hepatotoxicity model." Journal of Advances in VetBio Science and Techniques 7, no. 2 (August 31, 2022): 185–93. http://dx.doi.org/10.31797/vetbio.1029373.

Full text

Abstract:

Hepatotoxicity refers to liver dysfunction associated with certain medical drugs and chemicals. Studies have shown that mesenchymal stem cells have a positive effect on the improvement of liver diseases. The aim of this study was to investigate the potential protective effects of fetal kidney-induced mesenchymal stem cells on Doxorubicin-induced hepatotoxicity in rats. Sprague dawley rats were divided into three groups as control, sham, and treatment group. Intraperitoneal mesenchymal stem cells were treated with BrdU prior to transplantation so that they could be followed up after invivo tran

APA, Harvard, Vancouver, ISO, and other styles

33

Ali Labib, Heba M. "Modification of alprazolam-induced liver injury by bone marrow-derived mesenchymal stem cells and the role of miRNA-192." European Journal of Anatomy 26, no. 6 (November 2022): 615–33. http://dx.doi.org/10.52083/ivll6465.

Full text

Abstract:

The group of drugs known as Benzodiazepines (BDZs) are among the most widely prescribed CNS-depressant drugs. Alprazolam (Alp) is a member of the BDZs family, commonly prescribed as an antipsychotic and anxiolytic agent. Induction of oxidative stress, impairment of cognitive functions and psychomotor skills, conformational alterations in hemoglobin structure and elevation of liver enzymes are among the side effects reported on the use of alprazolam. Several studies have found that alprazolam could favor hepatotoxicity, whereas other studies contradicted those findings. Bone marrow-derived mese

APA, Harvard, Vancouver, ISO, and other styles

34

Zarrinpar, Ali. "Metabolic Pathway Inhibition in Liver Cancer." SLAS TECHNOLOGY: Translating Life Sciences Innovation 22, no. 3 (March 17, 2017): 237–44. http://dx.doi.org/10.1177/2472630317698683.

Full text

Abstract:

Liver cancer is fundamentally physiologically different from the surrounding liver tissue. Despite multiple efforts to target the altered signaling pathways created by oncogenic mutations, not many have focused on targeting the altered metabolism that allows liver cancer to develop and grow. Still to be resolved is the question of whether the altered metabolic pathways in this cancer differ enough from the surrounding noncancerous cells to allow for the development of potent and specific compounds. Clinical studies of metabolic modulators would provide some more information with regard to the

APA, Harvard, Vancouver, ISO, and other styles

35

Teixeira, Sarah Fernandes, Isabella dos Santos Guimarães, Klesia Pirola Madeira, Renata Dalmaschio Daltoé, Ian Victor Silva, and Leticia Batista Azevedo Rangel. "Metformin synergistically enhances antiproliferative effects of cisplatin and etoposide in NCI-H460 human lung cancer cells." Jornal Brasileiro de Pneumologia 39, no. 6 (December 2013): 644–49. http://dx.doi.org/10.1590/s1806-37132013000600002.

Full text

Abstract:

OBJECTIVE: To test the effectiveness of combining conventional antineoplastic drugs (cisplatin and etoposide) with metformin in the treatment of non-small cell lung cancer in the NCI-H460 cell line, in order to develop new therapeutic options with high efficacy and low toxicity.METHODS: We used the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and calculated the combination index for the drugs studied.RESULTS: We found that the use of metformin as monotherapy reduced the metabolic viability of the cell line studied. Combining metformin with cisplatin or etoposide pro

APA, Harvard, Vancouver, ISO, and other styles

36

Domnina, L. V., J. A. Rovensky, J. M. Vasiliev, and I. M. Gelfand. "Effect of microtubule-destroying drugs on the spreading and shape of cultured epithelial cells." Journal of Cell Science 74, no. 1 (March 1, 1985): 267–82. http://dx.doi.org/10.1242/jcs.74.1.267.

Full text

Abstract:

The role of microtubules in the spreading of cells from the liver-derived IAR2 rat cell line was studied. Cells in the control medium seeded on a flat isotropic glass surface rapidly spread to form discoid shapes. Spreading in colcemid-containing medium was disorganized and delayed; partial reversal of spreading was observed. Nevertheless, even in the presence of colcemid the cells finally spread to discoid flattened shapes. IAR2 cells in medium without colcemid spread not to discoid but to elongated shapes under three different sets of conditions: (1) when the cells were forced to spread on n

APA, Harvard, Vancouver, ISO, and other styles

37

Chen, Zhiliang, Tony C. H. Chow, Shicong Wang, Gigi C. T. Leung, Sharon L. Y. Wu, and David T. Yew. "Reaction of the Liver upon Long-Term Treatment of Fluoxetine and Atorvastatin Compared with Alcohol in a Mouse Model." Journal of Toxicology 2021 (December 30, 2021): 1–8. http://dx.doi.org/10.1155/2021/9974969.

Full text

Abstract:

Background. Alcoholism is known to cause liver toxicity and is extensively researched. On the other hand, stress, depression, and obesity are interrelated conditions with alcoholism, and their medications would affect the liver itself. In this study, we investigated the effects of the drugs fluoxetine and atorvastatin on the liver and compared with those of alcohol in a mouse model. Methods. Comparisons of animals treated with the three drugs were carried out: serum aspartate transaminase (AST), alanine transaminase (ALT), and albumin were measured; liver tumor necrosis factor alpha (TNF alpha

APA, Harvard, Vancouver, ISO, and other styles

38

Lin, Chun-Ching, Jer-Min Lin, and Hui-Fen Chiu. "Studies on Folk Medicine "Thang-kau-tin" from Taiwan (I) The Anti-inflammatory and Liver-protective Effect." American Journal of Chinese Medicine 20, no. 01 (January 1992): 37–50. http://dx.doi.org/10.1142/s0192415x92000059.

Full text

Abstract:

Five species of crude drugs are used as "Thang-kau-tin" on Taiwan market: (1) the stem of Mallotus repandus (Willd.) Muell. -Arg, (2) the stem and root of M. repandus (Willd.) Muell. -Arg, (3) the stem of Bauhinia championii Benth, (4) the stem with hooks of Uncaria hirsuta Haviland and (5) the stem with hooks of U. rhynchophylla Miquel. To clarify the effect of these crude drugs as anti-inflammatory and liver-protective agents, studies were conducted on water extracts of these five crude drugs. The statistical analysis (ANOVA) indicated that the stem of M. repandus showed the best anti-inflam

APA, Harvard, Vancouver, ISO, and other styles

39

Zheng, Rendong, Kemian Liu, Kun Chen, Wen Cao, Lin Cao, Huifeng Zhang, Hongping Sun, and Chao Liu. "Lithium Carbonate in the Treatment of Graves’ Disease with ATD-Induced Hepatic Injury or Leukopenia." International Journal of Endocrinology 2015 (2015): 1–7. http://dx.doi.org/10.1155/2015/694023.

Full text

Abstract:

Objective. GD with ATD-induced hepatic injury or leukopenia occurs frequently in clinical practice. The purpose of the present study was to observe the clinical effect of lithium carbonate on hyperthyroidism in patients with GD with hepatic injury or leukopenia.Methods. Fifty-one patients with GD with hepatic injury or leukopenia participated in the study. All patients were treated with lithium carbonate, in addition to hepatoprotective drugs or drugs that increase white blood cell count. Thyroid function, liver function, and white blood cells were measured. Clinical outcomes were observed aft

APA, Harvard, Vancouver, ISO, and other styles

40

Baothman, Othman, Bhaa Nagaty, Mazin Zamzami, and Hasan Al-Talhi. "In vivo protective effect of cinnamon aqueous extract in carbon tetrachloride-treated male albino rats." Acta Scientiarum. Health Sciences 43 (October 13, 2021): e52826. http://dx.doi.org/10.4025/actascihealthsci.v43i1.52826.

Full text

Abstract:

The liver as an organ is important for the metabolism of drugs and toxins. However, it is not immune from environmental insults. Exposure of liver cells to carbon tetrachloride (CCl4) results in the generation of tricholoromethyl radicals, which induce liver toxicity. This study aims at investigating the ameliorative effect of the cinnamon aqueous extract (CAE) against CCl4-induced hepatotoxicity in male albino rats. Hepatotoxicity was induced in rats through the intraperitoneal administration of 0.5 mL kg-1 body weight of CCl4. The analyses of the results obtained showed significant reduction

APA, Harvard, Vancouver, ISO, and other styles

41

Mishra, Nidhi, Narayan Prasad Yadav, Vineet Kumar Rai, Priyam Sinha, Kuldeep Singh Yadav, Sanyog Jain, and Sumit Arora. "Efficient Hepatic Delivery of Drugs: Novel Strategies and Their Significance." BioMed Research International 2013 (2013): 1–20. http://dx.doi.org/10.1155/2013/382184.

Full text

Abstract:

Liver is a vital organ responsible for plethora of functions including detoxification, protein synthesis, and the production of biochemicals necessary for the sustenance of life. Therefore, patients with chronic liver diseases such as viral hepatitis, liver cirrhosis, and hepatocellular carcinoma need immediate attention to sustain life and as a result are often exposed to the prolonged treatment with drugs/herbal medications. Lack of site-specific delivery of these medications to the hepatocytes/nonparenchymal cells and adverse effects associated with their off-target interactions limit their

APA, Harvard, Vancouver, ISO, and other styles

42

Abdu, Suzan, Nouf Juaid, Amr Amin, Mohamed Moulay, and Nabil Miled. "Therapeutic Effects of Crocin Alone or in Combination with Sorafenib against Hepatocellular Carcinoma: In Vivo & In Vitro Insights." Antioxidants 11, no. 9 (August 25, 2022): 1645. http://dx.doi.org/10.3390/antiox11091645.

Full text

Abstract:

This study investigated the therapeutic effects of the phytochemical crocin alone or in combination with sorafenib both in rats chemically induced with hepatocellular carcinoma (HCC) and in human liver cancer cell line (HepG2). Male rats were randomly divided into five groups, namely, control group, HCC induced group, and groups treated with sorafenib, crocin or both crocin and sorafenib. HCC was induced in rats with a single intraperitoneal injection of diethylnitrosamine (DEN), then 2-acetylaminofluorene (2-AAF). The HCC-induced rats showed a significant decrease in body weight compared to a

APA, Harvard, Vancouver, ISO, and other styles

43

Poojari, Radhika, Rohit Srivastava, and Dulal Panda. "Microtubule targeted therapeutics loaded polymeric assembled nanospheres for potentiation of antineoplastic activity." Faraday Discussions 186 (2016): 45–59. http://dx.doi.org/10.1039/c5fd00123d.

Full text

Abstract:

Polymeric nanoassemblies represent an attractive strategy for efficient cellular internalization of microtubule targeted anticancer drugs. Using dynamic light scattering, zeta potential, transmission electron microscopy and scanning electron microscopy, the physical properties and surface morphology of microtubule-binding PEGylated PLGA assembled nanospheres (100–200 nm) were analyzed. The present approach leads to strong internalization as observed by confocal laser scanning microscopy and transmission electron microscopy in hepatocarcinoma cells. The effect of these nanoassemblies on microtu

APA, Harvard, Vancouver, ISO, and other styles

44

Weiz, Gisela, Alina L. Gonzalez, Flavia Piccioni, Mariel Fusco, Marco Diaz Gutiérrez, Guillermo Mazzolini, Javier D. Breccia, Mariana Malvicini, and Maria I. Molejon. "Abstract 5447: Enhanced antitumoral effect of the glycosylated 4-methylumbelliferone in hepatocellular carcinoma." Cancer Research 82, no. 12_Supplement (June 15, 2022): 5447. http://dx.doi.org/10.1158/1538-7445.am2022-5447.

Full text

Abstract:

Abstract Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer-related death worldwide, and is particularly refractory to the available therapeutic drugs. Unfortunately, curative treatments such as surgery, liver transplantation, or ablation are reserved for early stages and can only be applied in less than 30% of the patients with HCC. Glycosylation can be a potent and interesting strategy for drug delivery to a specific target. We enzymatically synthesized a glycosylated derivative of the coumarin 4-methylumbelliferone (4MU), namely 4MUR.The antitumoral effect of 4MUR in compa

APA, Harvard, Vancouver, ISO, and other styles

45

Pantea, Valeriana, Vitalie Cobzac, Olga Tagadiuc, Victor Palarie, and Valentin Gudumac. "In Vitro Evaluation of the Cytotoxic Potential of Thiosemicarbazide Coordinating Compounds in Hepatocyte Cell Culture." Biomedicines 11, no. 2 (January 26, 2023): 366. http://dx.doi.org/10.3390/biomedicines11020366.

Full text

Abstract:

Cancer is a global medical problem and, despite research efforts in the field of tumor treatment, there is currently a shortage of specific anticancer drugs. Most anticancer drugs show significant side effects. The liver is the organ that has central functions in drug metabolism, being a major target of the harmful action of anticancer compounds. In this context, it is essential to evaluate the cytotoxic effects of potential anticancer substances. Therefore, hepatotoxicity and hepatocyte viability were determined in vitro to evaluate the action of seven new local thiosemicarbazide coordination

APA, Harvard, Vancouver, ISO, and other styles

46

Dobrzynska, Malgorzata, Marta Napierala, and Ewa Florek. "Flavonoid Nanoparticles: A Promising Approach for Cancer Therapy." Biomolecules 10, no. 9 (September 2, 2020): 1268. http://dx.doi.org/10.3390/biom10091268.

Full text

Abstract:

Flavonoids, a ubiquitous group of naturally occurring polyphenolic compounds, have recently gained importance as anticancer agents. Unfortunately, due to low solubility, absorption, and rapid metabolism of dietary flavonoids, their anticancer potential is not sufficient. Nanocarriers can improve the bioavailability of flavonoids. In this review we aimed to evaluate studies on the anticancer activity of flavonoid nanoparticles. A review of English language articles published until 30 June 2020 was conducted, using PubMed (including MEDLINE), CINAHL Plus, Cochrane, and Web of Science data. Most

APA, Harvard, Vancouver, ISO, and other styles

47

Balabolkin, M. I., and L. B. Nedosugova. "The use of second generation sulfonylurea agents and the role of glurenorm in the therapy of non-insulin-dependent diabetes mellitus." Problems of Endocrinology 41, no. 2 (April 15, 1995): 11–14. http://dx.doi.org/10.14341/probl11362.

Full text

Abstract:

Sulfonylurea drugs stimulate the 1st phase of insulin secretion, activate adenylate cyclase, inhibit phosphodiesterase or cause prolonged depolarization of the beta cell membrane. The peripheral effect of the hypoglycemic action of sulfonylurea drugs is mediated through the effect on insulin receptors. It is clearly shown that sulfonylureas lead to an increase in the number of receptors on target cells (hepatocytes, muscle and adipose tissue, lymphocytes and other cells). It is known that patients with type II diabetes mellitus have a decrease in both the number of receptors and their affinity

APA, Harvard, Vancouver, ISO, and other styles

48

Li, Shao-wei, Yue Cai, Xin-li Mao, Sai-qin He, Ya-hong Chen, Ling-ling Yan, Jing-jing Zhou, Ya-qi Song, Li-ping Ye, and Xian-bin Zhou. "The Immunomodulatory Properties of Mesenchymal Stem Cells Play a Critical Role in Inducing Immune Tolerance after Liver Transplantation." Stem Cells International 2021 (September 4, 2021): 1–14. http://dx.doi.org/10.1155/2021/6930263.

Full text

Abstract:

Although liver transplantation is considered to be the best choice for patients with end-stage liver diseases, postoperative immune rejection still cannot be overlooked. Patients with liver transplantation have to take immunosuppressive drugs for a long time or even their entire lives, in which heavy economic burden and side effects caused by the drugs have become the major impediment for liver transplantation. There is a growing body of evidences indicating that mesenchymal stem cell (MSC) transplantation, a promising tool in regenerative medicine, can be used as an effective way to induce im

APA, Harvard, Vancouver, ISO, and other styles

49

Lin, Chun-Ching, Pei-Chen Huang, and Jer-Min Lin. "Antioxidant and Hepatoprotective Effects ofAnoectochilus formosanusandGynostemma pentaphyllum." American Journal of Chinese Medicine 28, no. 01 (January 2000): 87–96. http://dx.doi.org/10.1142/s0192415x00000118.

Full text

Abstract:

Anoectochilus formosanus Hay. and Gynostemma pentaphyllum Makino are popular folk medicines that have been used for treating hepatitis, hypertension and cancer in Taiwan. Our previous studies showed that these crude drugs exert antiinflammatory activity and hepatoprotective activity against CCI4-induced liver damage. In this study, the antioxidant effect of these crude drugs and their hepatoprotective activity on acetaminophen-induced liver injury in rat was evaluated. Our results suggest that A. formosanus and G. pentaphyllum do have antioxidant effects. On acetaminophen-intoxicated model, th

APA, Harvard, Vancouver, ISO, and other styles

50

McVicker, Benita L., Frederick G. Hamel, Ronda L. Simpson та Robert G. Bennett. "A Selective PPARγ Modulator Reduces Hepatic Fibrosis". Biology 9, № 7 (2 липня 2020): 151. http://dx.doi.org/10.3390/biology9070151.

Full text

Abstract:

Hepatic fibrosis is the accumulation of excess collagen as a result of chronic liver injury. If left unabated, hepatic fibrosis can lead to the disruption of the liver architecture, portal hypertension, and increased risk of progression to cirrhosis and hepatocellular carcinoma. The thiazolidinedione class of antidiabetic drugs, through their target peroxisome proliferator-activated receptor γ (PPARγ), have protective effects against liver fibrosis, and can inhibit the profibrotic activity of hepatic stellate cells, the major collagen-producing liver cells. However, these drugs have been ineff

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!