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Journal articles on the topic 'Liver function enzyme activities'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Mommsen, T. P., and P. J. Walsh. "Metabolic and enzymatic heterogeneity in the liver of the ureogenic teleost Opsanus beta." Journal of Experimental Biology 156, no. 1 (1991): 407–18. http://dx.doi.org/10.1242/jeb.156.1.407.

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Viable toadfish hepatocytes were separated into distinct subpopulations by gradient centrifugation. Although 3–5 density subpopulations were obtained for each fish, only two metabolically and enzymatically different subpopulations could be discerned. In all cases, hepatocytes with the lowest density (less than 1.040 g ml-1) were more oxidative in scope, as judged by the activities of mitochondrial enzymes (citrate synthase, aspartate aminotransferase, glutamate dehydrogenase); activities of these enzymes (normalised to cell protein) were on average two- to threefold higher than in subpopulatio

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2

Merrill, A. H., E. Wang, D. P. Jones, and J. L. Hargrove. "Hepatic function in rats after spaceflight: effects on lipids, glycogen, and enzymes." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 252, no. 2 (1987): R222—R226. http://dx.doi.org/10.1152/ajpregu.1987.252.2.r222.

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The inclusion of rats aboard Spacelab 3 (SL-3) allowed analyses of liver lipids, glycogen, hepatic enzymes of cholesterol, glycerolipid and sphingolipid biosynthesis, and other enzyme activities. Glycogen content was markedly elevated in livers from the flight animals compared with controls. Cholesterol was 24% (P less than 0.04) lower in livers from the experimental groups, whereas blood cholesterol was 19% higher (P less than 0.05). The activity of 3-hydroxy-3-methylglutaryl-CoA reductase, the rate-limiting enzyme of steroid biosynthesis, was 80% lower (P less than 0.01). Total phospholipids

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3

Hisar, Olcay, Adem Yavuz Sönmez, Şükrü Beydemir, Şükriye Aras Hisar, Telat Yanik, and Tom Cronin. "Kinetic Behaviour of Glucose 6-Phosphate Dehydrogenase and 6-Phosphogluconate Dehydrogenase in Different Tissues of Rainbow Trout (Oncorhynchus mykiss) Exposed to Non-Lethal Concentrations of Cadmium." Acta Veterinaria Brno 78, no. 1 (2009): 179–85. http://dx.doi.org/10.2754/avb200978010179.

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The effects of cadmium (Cd) on the enzymatic activities of glucose 6-phosphate dehydrogenase (G6PD) and 6-phosphogluconate dehydrogenase (6PGD) were investigated in the gill, liver and kidney tissues of rainbow trout (Oncorhynchus mykiss). Three test groups of fish were subjected to increasing concentrations (1, 3 and 5 mg/l) of cadmium (Cd) in vivo, respectively. The G6PD and 6PGD activities in the gill, liver, and kidney tissues of each group of fish were measured on days 1, 3, 5 and 7. G6PD and 6PGD enzyme activities, measured in gill, liver and kidney homogenates, were stimulated by variou

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Tsai, C. Stan, and Loola S. Al-Kassim. "Multifunctional activities of pickerel liver alcohol dehydrogenase." Biochemistry and Cell Biology 71, no. 9-10 (1993): 427–31. http://dx.doi.org/10.1139/o93-063.

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A major isozyme of pickerel liver alcohol dehydrogenase has been purified to homogeneity. The enzyme, in addition to catalyze NAD(P)+-linked dehydrogenation of alcohols, also mediates dismutation of aldehydes and hydrolysis of esters. Steady-state kinetic studies and chemical modifications of the pickerel liver enzyme with respect to its esterolytic and dismutative activities were carried out. Pickerel liver alcohol dehydrogenase catalyzes hydrolyses of p-nitrophenyl esters via a Uni-Bi mechanism, with alkanoic acids as the last product released. Modifications of Cys and Lys suppress the ester

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Aydın, Birsen, Ali Oğuz, Vedat Şekeroğlu, and Zülal Atlı Şekeroğlu. "Whey protein protects liver mitochondrial function against oxidative stress in rats exposed to acrolein." Archives of Industrial Hygiene and Toxicology 73, no. 3 (2022): 200–206. http://dx.doi.org/10.2478/aiht-2022-73-3640.

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Abstract Acrolein (AC) is one of the most toxic environmental pollutants, often associated with incomplete combustion of petrol, wood, and plastic, oil frying, and tobacco smoking, that causes oxidative damage to DNA and mitochondria. Considering that little is known about the protective effects of whey protein (WP) against AC-induced liver toxicity, the aim of our study was to learn more about them in respect to liver mitochondrial oxidative stress, respiratory enzymes, Krebs cycle enzymes, and adenosine triphosphate (ATP). To do that, we treated Sprague Dawley rats with daily doses of AC alo

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Dhungana, Arun, Arun Pandeya, Dipesh Shakya, and Baburam Pokharel. "EFFECT OF DIFFERENT ANTICONVULSANTS ON LIVER ENZYME ACTIVITIES IN PATIENTS WITH SEIZURE DISORDER." Journal of Chitwan Medical College 12, no. 1 (2022): 48–52. http://dx.doi.org/10.54530/jcmc.609.

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Background: Epilepsy is a common chronic neurological disorder characterized by recurrent unprovoked seizures, which has transient signs and/or symptoms of abnormal, synchronous neuronal activity in the brain. Antiepileptic drugs (AEDs) used for the prevention of seizure have been found to be an inducer of liver enzyme activity. So, the purpose of this study was to see the effect of antiepileptic drugs on hepatic enzymes activity. Methods: An observational study was carried out in Kathmandu Medical College from October 2020 to April 2021 at neurology department. Sixty-seven seizure patients ag

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Muhsin, Salwa Suber, Eman Hussain Jafar, and Nasser Sadaq Jafar. "Biochemical study on the effect of Toxoplasma gondii on Liver function in Women." Iraqi Journal of Veterinary Medicine 37, no. 2 (2013): 257–60. http://dx.doi.org/10.30539/ijvm.v37i2.1390.

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The aim of this study was to detect the effect of toxoplasmosis on some liver enzyme activity such as bilirubin concentration, Alanine aminotransferase (ALT), Aspartate aminotransferase (AST), Alkaline Phosphatase (ALP) in serum. Twenty hundred and fifty women were examining by Enzyme-linked immunosorbent assay (ELISA). One hundred and thirty-four were infected with toxoplasmosis with different number of abortion (1-4) times were used in this work. All Serum ALT and AST activities were increased and ALP and total bilirubin level decreased in infected women below the normal value. The analysis

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Pietsch, C., and P. Burkhardt-Holm. "Feed-borne exposure to deoxynivalenol leads to acute and chronic effects on liver enzymes and histology in carp." World Mycotoxin Journal 8, no. 5 (2015): 619–27. http://dx.doi.org/10.3920/wmj2015.1879.

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Deoxynivalenol (DON) is a frequent contaminant of feeds in aquaculture, but the consequences of this contamination have rarely been evaluated. Previous studies on carp indicated effects of DON on liver function and histology after four weeks of feeding. The present study aimed to unravel the time course of liver responses of carp to orally applied DON. Therefore, liver enzyme activities and histology have been investigated after 7, 14, 26 and 56 days of DON feeding. The acute response comprises down-regulation of biotransformation enzymes, whereas the chronic response to DON is characterised b

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An, Cuilan, Lingling Wang, Yongli Liu, Emmanuel Ayobami Makinde, Huilian Li, and Opeyemi Joshua Olatunji. "Therapeutic Effects of 5,7-Dihydroxy-6-Oxoheptadecanoic Acid on Dysglycemia, Dyslipidemia, and Other Complications in Diabetic Rats." Natural Product Communications 15, no. 7 (2020): 1934578X2093720. http://dx.doi.org/10.1177/1934578x20937203.

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The current study aimed to investigate the therapeutic effects of 5,7-dihydroxy-6-oxoheptadecanoic acid (DHA) from Tiliacora triandra on rat models of type 2 diabetes mellitus (T2DM). T2DM was induced with a combination of high-fat diet/streptozotocin (HFD/STZ), and diabetic rats were treated with DHA (25 mg/kg) for 30 days. The body weight, fasting blood glucose (FBG), serum, and liver biochemical parameters, as well as histological evaluations of the liver and pancreas, were evaluated. Diabetic rats displayed a significant increase in FBG, serum lipid profiles (triglycerides, total cholester

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10

Merrill, A. H., E. Wang, R. LaRocque, et al. "Differences in glycogen, lipids, and enzymes in livers from rats flown on COSMOS 2044." Journal of Applied Physiology 73, no. 2 (1992): S142—S147. http://dx.doi.org/10.1152/jappl.1992.73.2.s142.

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Livers from rats flown aboard COSMOS 2044 were analyzed for protein, carbohydrate (glycogen), and lipids as well as the activities of a number of key enzymes involved in metabolism of these compounds and xenobiotics. The major differences between the flight group and the synchronous control were elevations in microsomal protein, liver glycogen content, tyrosine aminotransferase, and tryptophan oxygenase and reductions in sphingolipids and the rate-limiting enzyme of heme biosynthesis, delta-aminolevulinic acid synthase. These results provide further evidence that spaceflight has pronounced and

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Pratiwi, Chalies Diah, Andyanita Hanif Hermawati, and Nosa Ika Cahyariza. "The Analysis of SGOT, SGPT, and ALP in Chili Farmers Exposed to Pesticides in Kendalbulur Village, Tulungagung." Prisma Sains : Jurnal Pengkajian Ilmu dan Pembelajaran Matematika dan IPA IKIP Mataram 13, no. 1 (2025): 51. https://doi.org/10.33394/j-ps.v13i1.10014.

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Chili farmers in Kendalbulur Village are the main subjects that have a great influence due to exposure to pesticide residues (toxicity). Pesticide toxicity affects enzymes produced by the liver that cause changes in its working system. This study aims to look at the characteristics and levels of the enzymes SGOT, SGPT, and ALP in chili farmers exposed to pesticides that perform spraying activities. The SGOT-SGPT liver function test is a health screening that combines the examination of SGOT and SGPT enzyme levels in the blood. The purpose of this liver function test is to detect hepatitis or c

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Ogbuagu, Dike H., Ikenna N. Nwachukwu, Anthony C. Nwazuluahu, and Nzoputa P. Kalakiya. "Haematotoxicological and hepatotoxic inductions of a geophagic substance (Calabash chalk) on the albino rat (Rattus norvegicus)." Journal of Environmental Toxicology and Public Health 2 (October 13, 2017): 14–26. https://doi.org/10.5281/zenodo.1010453.

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This study investigated probable effects of a geophagic material - <em>Calabash chalk</em> on the haematology and liver enzyme activities of the mammalian model- <em>Rattus norvegicus</em>. Twenty four albino rats were acclimatised and exposed to 12.5, 25.0 and 50.0 % (w/w) toxicant-feed mixture. After 2 weeks, the animals were sacrificed and their blood as well as liver enzyme function activities were assessed. The higher toxicant concentrations induced lower body weights in the mammals [F<sub>(4618.5)</sub>>F<sub>crit(4.30)</sub>] at p<0.05. Mean maximum white blood cell (15.0±8.84x10<

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DAHIWAL, A. S., and R. C. D’SOUZA. "HEPATOTOXICITY STUDY OF ACUTE AND CHRONIC EXPOSURE TO DI(2-ETHYHEXYL) PHTHALATE (DEHP) IN ZEBRAFISH, DANIO RERIO." Pollution Research 42, no. 04 (2023): 527–32. http://dx.doi.org/10.53550/pr.2023.v42i04.021.

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Di(2-ethyhexyl) phthalate (DEHP) is the most widely known phthalate and worldwide the production and application of it is increasing over the last few years. In the present study, the impact of DEHP for acute (96 hours) and chronic (21 days) exposure to concentrations of 80, 140 and 200 g/l on liver of zebrafish, Danio rerio. Hepatotoxicity studies involved evaluation of liver function enzymes such as acid phosphatase (ACP), alkaline phosphatase (ALP), alanine transaminase (ALT) and aspartate transaminase (AST) as well as the antioxidant enzyme activities namely superoxide dismutase (SOD), ca

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14

Jahan, Ishrat, Md Didarul Islam, Sumaia Sarif, et al. "Tempol Alters Antioxidant Enzyme Function, Modulates Multiple Genes Expression, and Ameliorates Hepatic and Renal Impairment in Carbon Tetrachloride (CCl4)-Intoxicated Rats." Livers 3, no. 1 (2023): 105–20. http://dx.doi.org/10.3390/livers3010010.

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The purpose of this study was to determine the effect of the superoxide dismutase mimic compound “tempol” on liver and renal damage in Long Evans male rats administered with carbon tetrachloride (CCl4). Methods: The antioxidant enzyme activity and oxidative stress parameters were investigated in the liver, kidney, and plasma tissues. Histological examination of the liver and kidney sections affirmed inflammatory cell infiltration, collagen deposition, and iron deposition. RT-PCR was also employed to evaluate the expression of oxidative stress and inflammatory genes. Results: The CCl4-administe

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15

Mikov, Ivan, Velibor Vasovic, Aleksandra Mikov, Svetlana Golocorbin-Kon, Karmen Stankov, and Momir Mikov. "Hypoglycemic effect of herbicide 2,4-dichlorophenoxyacetic acid (2,4-D)." Pesticidi i fitomedicina 25, no. 4 (2010): 349–52. http://dx.doi.org/10.2298/pif1004349m.

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Herbicide 2,4-dichlorophenoxyacetic acid (2,4-D), a synthetic auxin which promotes uncontrolled plant growth is widely used. The aim of our study was to investigate, using an experimental model, the effect of herbicide 2,4-D on liver function tests, enzyme a amylase and glucose blood level. BALB/C mice were treated i.p. with the herbicide (30 mg/ kg 2,4-D) for four consecutive days. Twenty-four hours after the last injection, the treated and the control animals were weighed and sacrificed for biochemical analysis: haematocrit, glucose blood level, serum activities of enzymes alanine aminotrans

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Suliman, Rasha S., Heyam S. Ali, Khulud Alhelal, et al. "Antioxidant Properties of Solenostemma argel Effervescent Tablets." Current Pharmaceutical Biotechnology 20, no. 8 (2019): 679–88. http://dx.doi.org/10.2174/1389201020666190617165300.

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Objective: In the present study, Solenostemma argel effervescent tablets were prepared from Argel methanolic extract. Methods: The tablets were examined for their ability to impede carbon tetrachloride (CCl4)-induced lipid peroxidation in mice liver. The antioxidant activities of the enzymes; super-oxide dismutase (SOD), glutathione peroxidase (GS-PX) along with malondialdehyde level were tested in liver tissues. Results: The obtained results indicated that the antioxidant enzyme activities were remarkably reduced while the level of Malondialdehyde (MDA), which shows lipid peroxidation, and th

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Navarro, Ana, and Alberto Boveris. "Rat brain and liver mitochondria develop oxidative stress and lose enzymatic activities on aging." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 287, no. 5 (2004): R1244—R1249. http://dx.doi.org/10.1152/ajpregu.00226.2004.

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The mitochondrial mass of rat brain and liver remained unchanged on aging in young adults, old adults, and senescent animals (28, 60, and 92 wk of age); the values were 15–17 and 29–31 mg protein/g for brain and liver, respectively. The whole aging process was associated with an increased content of the oxidation products, thiobarbituric acid-reactive substances and protein carbonyls, by 61–69% in brain and 36–45% in liver, respectively. The activities of critical enzymes for mitochondrial function, mitochondrial nitric oxide synthase, Mn-superoxide dismutase, complex I, and complex IV, decrea

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AL-Qayim, M. A. "EFFECTS OF FENUGREEK SEED ON HEPATIC CELLULAR FUNCTION'S IN LAYING HENS." Iraqi Journal of Veterinary Medicine 24, no. 2 (2000): 196–211. http://dx.doi.org/10.30539/ijvm.v24i2.1177.

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The seeds of Trigonella foenum graecum (Fenugreek) was fed to laying hens at dietary level of 6% for 28 days. FG seeds generally had no toxic effects as evidence by normal liver function tests. Histological examination of liver sections from FG seeds fed hens (groupT) lack of any histopathological changes as compared with hens fed basal diet (groupC), and the activities of plasma transaminases enzymes were not altered. On the other hand the plasma level of ALP enzyme significantly increased under the effects of feeding FG seeds. Plasma sugar of groupT revealed a significant elevation correlate

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Chukwu, C. N., R. I. Uroko, S. I. Egba, F. A. Adamude, and C. L. Asadu. "Effects of Combined Ethanol Extract of Anthocleista Vogelii and Alstonia Boonei Stem Barks on Liver Function Indices in Benign Prostatic Hyperplasia Induced." Nigerian Journal of Pharmaceutical Research 16, no. 2 (2021): 191–201. http://dx.doi.org/10.4314/njpr.v16i2.10.

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Objective: This study evaluated the effects of combined ethanol extract of Anthocleista vogelii and Alstonia boonei (CEAA) stem barks on the liver function indices of benign prostatic hyperplasia (BPH)-induced rats.Materials and Methods: Thirty (30) male Wistar rats were randomly grouped into five groups (n = 6). BPH was induced subcutaneously with 5 mg/kg/day of testosterone propionate in olive oil. Groups 1-3 served as normal, BPH control (untreated) and standard drug control respectively, while Groups 4 and 5 were BPH-induced rats and treated with 200 and 400 mg/kg/day of the CEAA respectiv

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RAFIQUE, Roozina, Anthony H. V. SCHAPIRA, and J. Mark COOPER. "Sensitivity of respiratory chain activities to lipid peroxidation: effect of vitamin E deficiency." Biochemical Journal 357, no. 3 (2001): 887–92. http://dx.doi.org/10.1042/bj3570887.

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Rats fed a vitamin E-depleted diet for 48 weeks had undetectable levels of vitamin E in the gastrocnemius muscle and liver, leading to elevated malondialdehyde levels in both tissues and an elevated GSH level in muscle. Skeletal-muscle mitochondria showed decreased mitochondrial respiratory chain (MRC) activities, whereas liver MRC activities were increased. Exposure of normal rat liver submitochondrial particles (SMPs) to an in vitro NADPH-dependent lipid peroxidation system resulted in a dose-dependent increase in lipid peroxidation and inhibition of complex I and complex IV activities. Comp

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Ezebuiro, Ijeoma, Avweresuoghene Ododo, and Uchechukwu Ifeanyichukwu Apugo. "Hepato-Renal Activities of Hydro-Methanol Leaf Extract of Cnidoscolus aconitifolius in Adult Male Wistar Rats." Journal of Drug Delivery and Therapeutics 11, no. 4 (2021): 5–9. http://dx.doi.org/10.22270/jddt.v11i4.4870.

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Introduction: Medicinal plants such as Cnidoscolus aconitifolius (CA) have been studied over the years for their protective and curative potentials against a myriad of common global health challenges such as hepatorenal injuries. Objectives: To ascertaining the effects of the hydromethanol leaf extract of CA (HMLECA) on hepato-renal parameters in adult male wistar rats. Method: A total of 18 adult male wistar rats were divided into 3 groups of six rats each. Group I served as the negative control which received distilled water while groups 2 and 3 served as extract treatment groups

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Pathak, Chandramani, Yogesh K. Jaiswal, and Manjula Vinayak. "Queuine promotes antioxidant defence system by activating cellular antioxidant enzyme activities in cancer." Bioscience Reports 28, no. 2 (2008): 73–81. http://dx.doi.org/10.1042/bsr20070011.

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Constant generation of ROS (reactive oxygen species) during normal cellular metabolism of an organism is generally balanced by a similar rate of consumption by antioxidants. Imbalance between ROS production and antioxidant defence results in an increased level of ROS, causing oxidative stress, which leads to promotion of malignancy. Queuine is a hyper-modified base analogue of guanine, found at the first anticodon position of the Q-family of tRNAs. These tRNAs are completely modified with respect to queuosine in terminally differentiated somatic cells; however, hypo-modification of Q-tRNAs is

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Bob, Chile-Agada Adaeze. "Comprehensive Assessment of the Impact of MSG and Soybean Consumption on Metabolic Health and Antioxidant Enzyme Activity." Contemp J Med Health Sci. 4, no. 2 (2022): 15–34. https://doi.org/10.5281/zenodo.10246335.

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 <strong>OBJECTIVES</strong><i>This study aimed to investigate the enduring physiological impacts of prolonged monosodium glutamate (MSG) and soybean consumption in rats, with a specific focus on liver and kidney function, antioxidant enzyme activities, and oxidative stress markers. Gender-specific differences in responses were also explored.</i><strong>METHOD</strong><i>Female and male rats were subjected to varying doses of MSG and soybeans over a 6-month period. Physiological responses were meticulously analyzed, encompassing liver enzyme concentrations, urea and creatinine levels, as

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Kushnir, Oleksandra Yu, Iryna Yaremiy, Kyrylo Pantsiuk, et al. "Pentose phosphate pathway of glucose-6-phosphate oxidation in the liver of rats with alloxan diabetes on the background of melatonin administrations and variable photoperiod." Polski Merkuriusz Lekarski 52, no. 5 (2024): 536–40. https://doi.org/10.36740/merkur202405109.

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Aim: To find out the influence of melatonin on the enzyme activities of glucose-6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase and transketolase in the liver of rats with alloxan diabetes under conditions of variable photoperiod. Materials and Methods: Experiments were conducted on male outbred white rats weighing 180}10 mg. Photoperiodic changes: 1) equinox (light from 8:00 a.m. to 8:00 p.m., 500 lux); 2) light throughout the day and night (500 lux); 3) darkness. Alloxan diabetes was induced by administration of a 5% solution of alloxan monohydrate at a dose of 170 mg/kg once. G

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Tavartkiladze, A., G. Simonia, I. Andronikashvili, et al. "Chronotherapy Enhances Melatonin Secretion and Liver Enzyme Activity, Improving Therapeutic Outcomes in Hodgkins Lymphoma Patients." Journal of Cancer Research 2, no. 1 (2024): 01–18. https://doi.org/10.64030/2578-3726.02.01.04.

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Introduction: Chronotherapy, the alignment of treatment with the body›s natural circadian rhythms, has shown promise in optimizing therapeutic efficacy and minimizing side effects in cancer treatment. This study investigates the impact of chronotherapy on melatonin secretion, liver enzyme activity, and clinical outcomes in Hodgkin›s lymphoma patients. The liver, a central organ in energy metabolism, exhibits circadian rhythms that regulate various metabolic processes. By synchronizing chemotherapy administration with these rhythms, we hypothesize that chronotherapy can enhance melatonin secret

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Shams, Gamal, Somia Allah, Raghda Ezzat, and Mahmoud Said. "Ameliorative effects of berberine and selenium against paracetamol-induced hepatic toxicity in rats." Open Veterinary Journal 14, (1) (Zagazig Veterinary Confer (2024): 292. http://dx.doi.org/10.5455/ovj.2024.v14.i1.26.

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Background: Paracetamol (PCM) overdosing induces hepatotoxicity, which can result in death if the dose is high enough and the patients are not given N-acetyl cysteine. Berberine (BBR) has a variety of biological proprieties including anti-inflammatory and antioxidant activities. Aim: Assessment of the potential effect of BBR and selenium when used alone or together on the paracetamol–induced acute hepatic toxicity in rats. Methods: This research involved 40 clinically healthy mature adult male albino rats, their weights ranged from 150-200 g and housed in standard conditions. Our study involve

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Uroko, Robert Ikechukwu, Henry Nnaemeka Ogbonna, Chinedu Aguwamba, Paul Chukwuemeka Nweje-Anyalowu, and Benedict Chidozie Umezurike. "Assessment of Hepatoprotective and Antioxidant Effect of Acioa barteri Extract (ABE) in Alloxan-Induced Diabetic Rats." Majalah Obat Tradisional 29, no. 1 (2024): 79. http://dx.doi.org/10.22146/mot.88682.

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This study aimed to investigate the effects of Acioa barteri extract (ABE) on hepatocellular enzyme activity, hepatic function, and antioxidant stress indices in diabetic rats induced with alloxan. The antidiabetic effect of ABE was evaluated in six experimental groups: normal controls, diabetics untreated, diabetics treated with 200mg/kg, 400mg/kg, or 800 mg/kg ABE, and diabetics treated with 3 mg/kg Glibenclamide. ABE was orally administered to induce diabetes, and alloxan-monohydrate was intraperitoneally administered. Diabetic untreated rats exhibited significantly elevated levels of alkal

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Ruoß, Marc, Georg Damm, Massoud Vosough, et al. "Epigenetic Modifications of the Liver Tumor Cell Line HepG2 Increase Their Drug Metabolic Capacity." International Journal of Molecular Sciences 20, no. 2 (2019): 347. http://dx.doi.org/10.3390/ijms20020347.

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Although human liver tumor cells have reduced metabolic functions as compared to primary human hepatocytes (PHH) they are widely used for pre-screening tests of drug metabolism and toxicity. The aim of the present study was to modify liver cancer cell lines in order to improve their drug-metabolizing activities towards PHH. It is well-known that epigenetics is strongly modified in tumor cells and that epigenetic regulators influence the expression and function of Cytochrome P450 (CYP) enzymes through altering crucial transcription factors responsible for drug-metabolizing enzymes. Therefore, w

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Osman, Ali, Abdalla El-Hadary, Aida A. Korish, et al. "Angiotensin-I Converting Enzyme Inhibition and Antioxidant Activity of Papain-Hydrolyzed Camel Whey Protein and Its Hepato-Renal Protective Effects in Thioacetamide-Induced Toxicity." Foods 10, no. 2 (2021): 468. http://dx.doi.org/10.3390/foods10020468.

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Papain hydrolysis of camel whey protein (CWP) produced CWP hydrolysate (CWPH). Fractionation of CWPH by the size exclusion chromatography (SEC) generated fractions (i.e., SEC-F1 and SEC-F2). The angiotensin converting enzyme inhibitory activity (ACE-IA) and free radical scavenging actions were assessed for CWP, CWPH, SEC-F1, and SEC-F2. The SEC-F2 exerted the highest ACE-IA and scavenging activities, followed by CWPH. The protective effects of CWPH on thioacetamide (TAA)-induced toxicity were investigated in rats. The liver enzymes, protein profile, lipid profile, antioxidant enzyme activities

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Sheweita, S. A., J. Mubark, M. J. Doenhoff, et al. "Changes in the expression of cytochrome P450 isozymes and related carcinogen metabolizing enzyme activities in Schistosoma mansoni-infected mice." Journal of Helminthology 76, no. 1 (2002): 71–78. http://dx.doi.org/10.1079/joh200186.

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AbstractMixed-function oxidase enzymes metabolize most xenobiotic agents. Western blotting was used to investigate the effect of Schistosoma mansoni infection on the expression of various cytochrome P450 (CYP) isozymes and specific enzyme assays to study related metabolic functions in mouse liver microsomes. Male BK-TO mice were infected with 200 cercariae per mouse and their livers were assayed at 6, 15, 30 and 45 days post-infection (p.i.) and compared with appropriately matched controls. The expression of each of the CYP isozymes (1A1, 2B1/2, 2C6, and 4A) was either unaffected or transientl

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Mrkvicová, Eva, Leoš Pavlata, Filip Karásek, et al. "The influence of feeding purple wheat with higher content of anthocyanins on antioxidant status and selected enzyme activity of animals." Acta Veterinaria Brno 85, no. 4 (2016): 371–76. http://dx.doi.org/10.2754/avb201685040371.

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The influence of anthocyanins on antioxidant activity and liver function was measured in three different animal species (rats, chickens and fish). Purple Konini wheat with the total anthocyanin content (TAC) of 41.70 mg/kg was fed to the experimental groups of animals (rats n = 32; chickens n = 32; fish n = 20). The same numbers of animals (control groups) were fed common wheat with TAC of 24.95 mg/kg. At the end of the experiment, the animals were killed and blood and liver tissues were taken for biochemical analyses. The liver enzyme activities were measured in blood. Antioxidant activity in

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Philip, Raiza, Michelle Mathias, Suchetha Kumari N., Damodara Gowda K. M., and Jayaprakash Shetty K. "EVALATION OF RELATIONSHIP BETWEEN MARKERS OF LIVER FUNCTION AND THE ONSET OF TYPE 2 DIABETES." Journal of Health and Allied Sciences NU 04, no. 02 (2014): 090–93. http://dx.doi.org/10.1055/s-0040-1703770.

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Abstract: Background and Objective: Type 2 diabetic individuals are highly prone to liver function test abnormalities than non-diabetic individuals. Increased activities of liver enzymes such as aspartate aminotransferase (AST), alanine aminotransferase (ALT), and ?- glutamyl transpeptidase (GGT) are indicators of hepatocellular injury. Increased activity of these markers is associated with insulin resistance [1], metabolic syndrome, and type 2 diabetes. Diabetes mellitus burden is one of the key concerns in developing countries like India. In this study, we evaluated the relationships between

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Barzanti, V., M. Battino, A. Baracca, et al. "The effect of dietary lipid changes on the fatty acid composition and function of liver, heart and brain mitochondria in the rat at different ages." British Journal of Nutrition 71, no. 2 (1994): 193–202. http://dx.doi.org/10.1079/bjn19940126.

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A correlation between dietary lipids and cellular enzyme activities is a problem that has only been partially addressed by nutritionists. Therefore, changes in the fatty acid composition and the activities of some key metabolic enzymes (ubiquinol-2-cytochrome c reductase (EC 1.10.2.2), cytochrome oxidase (EC 1.9.3.1) and ATPase (EC 3.6.1.3)) in the mitochondria of liver, heart and brain of rats fed on diets differing extensively in their polyunsaturated fatty acid compositions have been investigated. The results showed that fatty acid compositional changes brought about by the dietary differen

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Memudu, Adejoke Elizabeth. "Androgenic Anabolic Steroids Perturb Hepatocellular Tissue Damage Mediated by Oxidative Stress in the Presence of Endogenous Antioxidant." Advances in Clinical Toxicology 9, no. 1 (2024): 1–13. http://dx.doi.org/10.23880/act-16000292.

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Objective of the study: Anabolic androgenic steroids (AASs) unlawfully misused for their anabolic effects has deleterious effects of major concerns in public health even in the presence of endogenously produced antioxidants. This study is to evaluate the interaction between AAS metabolites and endogenously produced superoxide dismutase (SOD) activity in AAS treatment and AAS abstinence. Materials and Methods: Twenty (20) adult male Wistar used were divided into four (4) groups, A and B served as the positive and negative control given normal saline and olive oil respectively, C and D was given

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Awhin, P. E., A. I. Ajoh, and B. Erutere. "Effect of Nutmeg on Transaminase Activities in Liver and Serum of Adult Wistar rats." Journal of Applied Sciences and Environmental Management 27, no. 3 (2023): 615–17. http://dx.doi.org/10.4314/jasem.v27i3.28.

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This study examines the activities of alanine aminotransaminase (ALT) and aspartate aminotransferase (AST) in the liver of 30 adult Wistar rats exposed to nutmeg for 30 days. 1 g of nutmeg was administered to group A (n=10), 2 g of nutmeg to group B (n=10) and group C (n=10) was used as the control. Enzyme activities were assayed in both serum and liver (tissue homogenate) spectrophotometrically. Results obtained showed a significant increase (p < 0.05) in level of AST in serum of rats in group A and B (20.2±7.29 and 23.2 ± 3.27 U/L) when compared to the control group (14.8± 1.78 U/L) while

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Khan, S., and A. D. Rahimtula. "The role of heme metabolism during the induction of hepatic and renal cytochrome P-450 levels and drug-metabolizing enzymes in rats by a Prudhoe Bay crude oil." Canadian Journal of Physiology and Pharmacology 65, no. 1 (1987): 75–79. http://dx.doi.org/10.1139/y87-014.

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Administration of Prudhoe Bay crude oil (PBCO) to rats resulted in a dose-related (i) increase in liver weight; (ii) rapid and marked increase in the activity of hepatic δ-aminolevulinate synthetase, the initial and rate-limiting enzyme in the heme biosynthetic pathway; (iii) rapid decline in the activity of hepatic heme oxygenase, the rate-limiting enzyme of heme catabolism; and (iv) more gradual increase in the levels of hepatic cytochrome P-450 and some mixed-function oxidase activities such as benzo[a]pyrene hydroxylase and 7-ethoxyresorufin-O-deethylase. PBCO treatment also increased rena

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Datsko, Vitalij А., Larisa Ya Fedoniuk, Yana I. Ivankiv, et al. "EXPERIMENTAL CIRRHOSIS: LIVER MORPHOLOGY AND FUNCTION." Wiadomości Lekarskie 73, no. 5 (2020): 947–52. http://dx.doi.org/10.36740/wlek202005120.

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The aim was to establish the morphofunctional changes of liver in the experimental cirrhosis. Materials and methods: The research was conducted on 24 white male Wistar rats. Experimental cirrhosis of the liver was simulated by oral administration of CCl4 2 g/kg 2 times weekly for three months. From the selected fragments of the liver, histological specimens were done according to the conventional method and examined by light microscopy. The activity of the enzymes of cytolysis and cholestasis (ALT, AST, alkaline phosphatase), the content of components of bile (cholesterol, bilirubin and bile a

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Mamun, Md Abdullah Al, Md Faruk, Md Mizanur Rahman, et al. "High Carbohydrate High Fat Diet Induced Hepatic Steatosis and Dyslipidemia Were Ameliorated by Psidium guajava Leaf Powder Supplementation in Rats." Evidence-Based Complementary and Alternative Medicine 2019 (February 3, 2019): 1–12. http://dx.doi.org/10.1155/2019/1897237.

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Psidium guajava leaf is reported to contain many bioactive polyphenols which play an important role in the prevention and treatment of various diseases. Our investigation aimed to study the effect of Psidium guajava leaf powder supplementation on obesity and liver status by using experimental rats. To study the effects of guava leaf supplementation in high fat diet induced obesity, rats were randomly divided into four experimental groups (n=7), control (group I), control + guava leaf (group II), HCHF (group III), and HCHF + guava leaf (group IV). At the end of the experimental period (56 days)

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Li, Yinhao, Qingyue Zhang, Yonghui Feng, et al. "Dietary Chitosan Supplementation Improved Egg Production and Antioxidative Function in Laying Breeders." Animals 12, no. 10 (2022): 1225. http://dx.doi.org/10.3390/ani12101225.

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This study was conducted to explore the dietary effect of chitosan on the production performance, and antioxidative enzyme activities and corresponding gene expression in the liver and duodenum of laying breeders. A total of 450 laying breeders (92.44% ± 0.030% of hen-day egg production) were randomly assigned to five dietary treatments fed 8 weeks: maize-soybean meal as the basal control diet and the basal diet containing 250, 500, 1000 and 2000 mg/kg of chitosan, respectively. Each treatment was randomly divided into 6 equal replicates, with 15 laying breeders in each replicate. The results

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Meyer, D. J., Karen A. Moriello, Brett M. Feder, Susan L. Fehrer-Sawyer, and Anna K. Maxwell. "Effect of otic medications containing glucocorticoids on liver function test results in healthy dogs." Journal of the American Veterinary Medical Association 196, no. 5 (1990): 743–44. http://dx.doi.org/10.2460/javma.1990.196.05.743.

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Summary Otic medications containing triamcinolone or dexamethasone were administered twice daily for 21 days to 2 groups of 4 healthy dogs each. Serum alkaline phosphatase, γ-glutamyltransferase, alanine transaminase, and aspartate transaminase activities, and serum bile acid and lipoprotein-X concentrations were assayed for 35 days. Increased serum activities for γ-glutamyltransferase, alkaline phosphatase, and alanine transaminase were detected by day 7 and peaked at day 21. Increases were greater in dogs given the dexamethasone-containing medication. Enzyme activity returned to baseline by

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Tugbobo OS, Idowu KS, Awonegan AP, Apata DA, and Olorunoje HA. "Effect of sub-acute administration of Phoradendron leucarpum ethanolic extract on hepatocytes of Wistar Rats." International Journal of Science and Technology Research Archive 3, no. 1 (2022): 054–57. http://dx.doi.org/10.53771/ijstra.2022.3.1.0063.

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The rapid incidence of liver disorders is rampant in our society today and there is this very need to salvage the sudden and untimely death resulting from liver disorders. In this study, aqueous extract of Phoradendron leucarpum leaf was administered orally at doses of 50, 100 and 200 mg/kg body weight to wistar rats. Twenty (20) rats were divided into four groups of five in each group of which one group served as the control. The other groups were treated with the ethanolic leaf extract 50, 100, and 200 mg/kg of Phoradendron leucarpum (mistletoe). The extract was administered orally and the a

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Oleshchuk, Ivankiv, Falfushynska, Mudra, and Lisnychuk. "Hepatoprotective Effect of Melatonin in Toxic Liver Injury in Rats." Medicina 55, no. 6 (2019): 304. http://dx.doi.org/10.3390/medicina55060304.

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Background and objectives: toxic liver injury results in nitrooxidative stress. Melatonin is a potent free radical scavenger, an inducible nitric oxide synthase (iNOS) inhibitor and an activator of antioxidant enzymes. The aim of this study was to investigate the hepatoprotective effect of exogenous melatonin on animals with acute toxic hepatitis. Material and methods: 36 healthy Sprague-Dawley male rats were split into three equal groups and given carbon tetrachloride (CCl4), 2 g/kg (CCl4 group) or the same dose of CCl4 and melatonin, 10 mg/kg (CCl4/melatonin group) or saline (control group).

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Inegbenehi, Ebehitale Comfort, Babatunde Ishola Gabriel Adejumo, Moses Ojo Oke, Fidelis Ohiremen Oyakhire, Uche Cletus Odionyenma, and Usman Itakure Abdulkadir. "Comparative analysis of ferritin levels and liver enzyme activity in liver disease patients within Benin City." Sokoto Journal of Medical Laboratory Science 9, no. 2 (2024): 213–20. https://doi.org/10.4314/sokjmls.v9i2.25.

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Liver disease encompasses a spectrum of hepatic pathologies, ranging from minor disturbances in liver function to severe conditions such as cirrhosis and hepatocellular carcinoma. The aim of this study was to assess the serum concentrations of ferritin and liver enzymes (aspartate aminotransferase [AST] and alanine aminotransferase [ALT]) in patients diagnosed with liver disease in Benin City, Edo State. A cohort of eighty-eight (88) individuals, consisting of forty-four (44) subjects diagnosed with various forms of liver disease and forty-four (44) healthy controls devoid of liver pathology h

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Ferreira, Rui, Fátima Candeias, Fátima Simões, José Nascimento, and J. Cruz Morais. "Effects of horminone on liver mixed function mono-oxygenases and glutathione enzyme activities of Wistar Rat." Journal of Ethnopharmacology 58, no. 1 (1997): 21–30. http://dx.doi.org/10.1016/s0378-8741(97)00073-1.

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Mayas, María Dolores, Cristina Cueto-Ureña, María Jesús Ramírez-Expósito, and José Manuel Martínez-Martos. "Differential Effects of Alcoholic and Non-Alcoholic Beer Intake on Renin–Angiotensin System Modulation in Spontaneous Hypertensive Rats." Applied Sciences 15, no. 2 (2025): 572. https://doi.org/10.3390/app15020572.

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This study investigates the effects of alcoholic (AB) and non-alcoholic beer (NAB) consumption on blood pressure and the activity of enzymes regulating the renin–angiotensin system (RAS) in Wistar–Kyoto (WKY) and spontaneously hypertensive rats (SHRs), with WKY rats used as normotensive controls for SHRs. The RAS is crucial for long-term blood pressure regulation, with angiotensin II (AngII) being a potent vasoconstrictor. The aim was to explore the biochemical mechanisms by which beer might influence cardiovascular health. WKY and SHRs were divided into groups receiving tap water (TW), non-al

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Yuliana, Ida, Triawanti Triawanti, Muhammad Darwin Prenggono, et al. "The Effects of Heavy Metal Contamination on Liver Function in a Rat Model." MAGNA MEDICA Berkala Ilmiah Kedokteran dan Kesehatan 11, no. 2 (2024): 145. http://dx.doi.org/10.26714/magnamed.11.2.2024.145-153.

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Background: Mining activities in South Kalimantan have been widely associated with the emergence of various health issues through heavy metal contamination in the water. Previous studies have demonstrated that the presence of heavy metals has an impact on physiological alterations inside many organs, notably the liver.Objective: The study aimed to determined the impact of liver damaged from heavy metal of lead (Pb), cadmium (Cd), and mercury (Hg), and the combination of the three in rat model.Methods: Our research used the true experiment laboratory method with a post-test group design. Male w

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Shekhawat, Prem, Michael J. Bennett, Yoel Sadovsky, D. Michael Nelson, Dinesh Rakheja, and Arnold W. Strauss. "Human placenta metabolizes fatty acids: implications for fetal fatty acid oxidation disorders and maternal liver diseases." American Journal of Physiology-Endocrinology and Metabolism 284, no. 6 (2003): E1098—E1105. http://dx.doi.org/10.1152/ajpendo.00481.2002.

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The role of fat metabolism during human pregnancy and in placental growth and function is poorly understood. Mitochondrial fatty acid oxidation disorders in an affected fetus are associated with maternal diseases of pregnancy, including preeclampsia, acute fatty liver of pregnancy, and the hemolysis, elevated liver enzymes, and low platelets syndrome called HELLP. We have investigated the developmental expression and activity of six fatty acid β-oxidation enzymes at various gestational-age human placentas. Placental specimens exhibited abundant expression of all six enzymes, as assessed by imm

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Muthukaruppiah, Gurusamy, and Nadanam Saravanan. "Hepatoprotective Effect of Quinic Acid Against Ethanol-Induced Liver Toxicity in Rats: Biochemical, Physiological, and Histological Insights." UTTAR PRADESH JOURNAL OF ZOOLOGY 46, no. 3 (2025): 118–33. https://doi.org/10.56557/upjoz/2025/v46i34791.

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Alcohol consumption is associated with several health issues, including Alcoholic Liver Disease (ALD). Quinic acid, a cyclic polyol compound, is known for its antioxidant, anticancer, anti-inflammatory, and hepatoprotective properties. This study aims to elucidate the protective mechanisms of quinic acid against ethanol-induced liver toxicity in rats. Male rats (n=32) were divided into four groups (n=8 per group) and treated over 60 days. Group 1 received a standard diet with isocaloric glucose; Group 2 was treated with 30% ethanol daily; Group 3 received 30% ethanol and quinic acid (50 mg/kg)

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Nazir, Nausheen, Muhammad Zahoor, Riaz Ullah, Essan Ezzeldin, and Gamal A. E. Mostafa. "Curative Effect of Catechin Isolated from Elaeagnus Umbellata Thunb. Berries for Diabetes and Related Complications in Streptozotocin-Induced Diabetic Rats Model." Molecules 26, no. 1 (2020): 137. http://dx.doi.org/10.3390/molecules26010137.

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In this study, catechin (CTN) isolated from Elaeagnus umbellata was evaluated for in vitro antioxidant potential and inhibition of carbohydrate digestive enzymes (α-amylase and α-glucosidase). The compound was also tested for its in vivo antidiabetic potential using Sprague-Dawley rats as experimental animals. The effects of various doses of catechin in STZ (Streptozotocin) induced diabetic rats on fasting blood glucose level, body weight, lipid parameters, hepatic enzymes, and renal functions were evaluated using the reported protocols. The CTN exhibited the highest percent antioxidant for fr

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Bardallo, Raquel G., Gabriela Chullo, Norma Alva, et al. "Mitigating Cold Ischemic Injury: HTK, UW and IGL-2 Solution’s Role in Enhancing Antioxidant Defence and Reducing Inflammation in Steatotic Livers." International Journal of Molecular Sciences 25, no. 17 (2024): 9318. http://dx.doi.org/10.3390/ijms25179318.

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Liver transplantation remains the only definitive treatment for end-stage liver diseases. However, the increasing prevalence of fatty liver disease among potential donors exacerbates the shortage of suitable organs. This study evaluates the efficacy of the preservation solution Institut Georges Lopez-2 (IGL-2) compared to Histidine–Tryptophan–Ketoglutarate (HTK) and University of Wisconsin (UW) preservation solutions in mitigating ischemia-reperfusion injury (IRI) in steatotic livers. Using Zucker Obese rat livers, we assessed the impact of 24-h static cold storage (SCS) with each solution on

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