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Dissertations / Theses on the topic 'Liver function tests (LTFs)'

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1

Chang, Ping. "Quantitative evaluation of hepatic morphological alterations and pharmacokinetic changes of cationic drugs in fibrosis-inducing hepatic diseases /." St. Lucia, Qld, 2001. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe16767.pdf.

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2

Gunawardhana, Lhanoo 1959. "Human liver slices: An in vitro system for determination of N-acetylation and acetylator status." Thesis, The University of Arizona, 1989. http://hdl.handle.net/10150/291394.

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An in vitro system has been developed to study N-acetyltransferase (NAT) activity using human liver slices in dynamic organ culture. Acetylation of para-aminobenzoic acid (PABA) and sulfamethazine (SMZ) in the presence of human liver slices was monitored by measuring the disappearance of the parent amine from the incubation medium using the colorimetric procedure of Bratton & Marshall. Presence of the acetyl conjugate was confirmed using HPLC. PABA acetylation rates varied from 0.72-2.52 nmoles/hr/mg protein (n = 8). This small variation (4 fold) is consistent with the classification of PABA a
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3

Mets, Berend. "Lignocaine extraction ratio and clearance as an indicator of hypoxic hepatic injury : a study using the in situ and the isolated perfused pig liver." Doctoral thesis, University of Cape Town, 1992. http://hdl.handle.net/11427/27152.

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The metabolism of lignocaine to monoethylglycinexylidide has been found useful as an indicator of hepatic function in association with liver transplantation. It has been postulated that this might be due to the common effect of hypoxic damage on liver function and lignocaine metabolism. The aim of this work was to establish whether hepatic lignocaine elimination was impaired by hypoxia and whether lignocaine extraction ratio and clearance could be used as an indicator of hepatic function. This was studied using the isolated pig liver perfused via the hepatic artery and portal vein. To establis
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4

Fisher, Scott Andrew. "Clinical and molecular analysis of the hepatitis C virus /." Connect to this title, 2005. http://theses.library.uwa.edu.au/adt-WU2006.0099.

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5

Love, James E. "The use of technetium-99m disofenin clearance as a test for hepatic function /." The Ohio State University, 1985. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487261919113285.

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6

Payne, John Thomas. "The effects of left hepatic vein ligation on hepatic circulation, function and microanatomy." Thesis, Virginia Polytechnic Institute and State University, 1989. http://hdl.handle.net/10919/53241.

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Eighteen healthy dogs were divided into three equal groups. All dogs were evaluated at the beginning of the experiment with complete physical examination, complete blood count, serum alanine aminotransferase, serum alkaline phosphatase, serum bilirubin, serum albumin, sulfobromophthalein. excretion test, ammonia tolerance test, glucagon response test, portal and intraparenchymal pressures, operative mesenteric portography, and histologic assessment of hepatic tissue. The left hepatic vein was ligated in the chronic and acute dogs. The dogs had a ligature placed loosely around the left hepati
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7

Ferreyra, M. E., M. C. Ocaña, E. N. Bullón, and Universidad Peruana de Ciencias Aplicadas (UPC). "Assessment with liver function tests and hydroperoxides in short term very-lowbirth-weight neonatal parenteral nutrition." Elsevier B.V, 2015. http://hdl.handle.net/10757/347040.

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LB003-MON<br>Abstracts of the 31st ESPEN Congress Vienna, Austria 29 August–1 September 2009<br>Rationale: It has been reported that PN (parenteral nutrition) in preterm neonates may have deleterious effects on hepatic function. We also studied the influence of peroxidation in PN bags, with and without light protection. Methods: 30 neonates weighing 1000 1500 g on TPN were studied prospectively. Serum samples were taken at start and at end of PN. Peroxides from 31 bags at 0, 5, 18 and 24 hours were measured. PN samples were taken from both light protected and not light protected PN b
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8

Hill, James Michael. "The utility of uric acid assay in dogs as an indicator of functional hepatic mass." Diss., University of Pretoria, 2010. http://hdl.handle.net/2263/27233.

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Laboratory serum biochemical tests are regarded by the Liver Study Group (LSG) of the WSAVA as an essential component of any liver investigation. The LSG categorised liver disease into four groups: vascular disorders, biliary disorders; parenchymal disorders and neoplasia. The laboratory tests that evaluate the liver have three categories. The cytosolic enzymes assess hepatocellular integrity; the cholestatic or inducible enzymes assess the biliary tree, liver excretory pathways and possible enzyme induction. The third category is the liver function tests which assess overall hepatic functiona
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9

Jonas, Eduard. "Imaging-based dynamic liver testing : studies of segmental hepatic parenchymal function and biliary flow using dynamic ⁹⁹Tcm-HIDA SPECT /." Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-376-7/.

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10

Kirchner, John P. "A Method for the Application of Computer Analytic Tools to Clinical Research: Neural Networks Analysis of Liver Function Tests to Assist in the differential Diagnosis of Liver Disease." NSUWorks, 1997. http://nsuworks.nova.edu/gscis_etd/638.

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There is a great deal of effort by medical educators in the instruction of the use of computers for clinical practice but little training in the methods and utility of computer applications in clinical research. In this paper I present a method for the application of computer analytic tools to clinical research. The steps described lead the student through the standard clinical research process and demonstrate the decision making that must take place in each step of any clinical research program. This example is based upon a valid and unique research question relating to my particular field of
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11

Fisher, Scott Andrew. "Clinical and molecular analysis of the hepatitis C virus." University of Western Australia. School of Biomedical, Biomolecular and Chemical Sciences, 2006. http://theses.library.uwa.edu.au/adt-WU2006.0099.

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[Truncated abstract] The hepatitis C virus (HCV) is a significant human pathogen for which there are limited post-infection therapies and no effective vaccine. Research into HCV is notoriously difficult due to the absence of suitable in vitro and in vivo model systems with which to study the virus. Furthermore, our understanding of HCV host interaction is limited and the mechanisms by which it subverts the host immune system remains largely unknown. Due to the difficult nature associated with studying HCV, the work presented in this thesis was designed to addresses a broad range of issues rela
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12

Hooks, Deborah Jane. "The effect of phenol denervation of the hepatic portal vein nerves on taste aversion learning." CSUSB ScholarWorks, 1993. https://scholarworks.lib.csusb.edu/etd-project/718.

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13

Almeida, André Guerra de. ""Correlações entre achados laboratoriais e doença hepática gordurosa não alcoólica em pacientes portadores de obesidade mórbida"." Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/5/5154/tde-11042006-163614/.

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Devido a controvérsias sobre a freqüência, diagnóstico e possibilidade de progressão para doença crônica da degeneração gordurosa do fígado em portadores de obesidade mórbida, planejou-se uma investigação retrospectiva em pacientes candidatos à cirurgia bariátrica. Foram analisados 60 indivíduos com indicação de gastroplastia com derivação intestinal em Y de Roux. Os pacientes foram submetidos a questionário clínico, provas bioquímicas e posteriormente, à biópsia hepática intraoperatória. A freqüência de EHNA e esteatose hepática foi elevada, e detectou-se 5% de cirrose. Na análise univariada
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14

Silva, Aurea Maria Oliveira da. "Eletromiografia de superfície de músculos respiratórios : avaliação de hepatopatas em lista de espera de transplante de fígado e de não hepatopatas." [s.n.], 2014. http://repositorio.unicamp.br/jspui/handle/REPOSIP/312442.

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Orientadores: Ilka de Fátima Santana Ferreira Boin, Alberto Cliquet Junior<br>Texto em português e inglês<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-08-24T19:22:29Z (GMT). No. of bitstreams: 1 Silva_AureaMariaOliveirada_D.pdf: 3321051 bytes, checksum: f6610f15d11aceeb44323830d9953cd0 (MD5) Previous issue date: 2014<br>Resumo: A eletromiografia de superfície (EMGs) é uma técnica não-invasiva para a detecção da atividade da musculatura esquelética, podendo ser utilizada para verificação da atividade dos músculos da
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15

Suárez, Catherine. "Function and regulation of a serine protease implicated in malaria parasite remodelling and egress." Thesis, Montpellier 2, 2012. http://www.theses.fr/2012MON20209.

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Le paludisme demeure une des maladies infectieuses les plus meurtrières au monde. Propagé par la piqûre d’un moustique femelle du genre Anopheles, le parasite du paludisme (Plasmodium) migre dans la circulation sanguine et infecte les cellules hépatiques de la victime. Dans le foie, le parasite se différencie et se reproduit par schizogonie à l’intérieur d’une vacuole parasitophore pour compléter la production de plusieurs milliers de mérozoïtes par cellule hépatique infectée. Ces mérozoïtes sont par la suite libérés dans la circulation sanguine où ils infectent les érythrocytes circulants dan
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16

Slobodan, Gigov. "Uticaj apigenina i natrijum-deoksiholata na biološku raspoloživost raloksifena." Phd thesis, Univerzitet u Novom Sadu, Medicinski fakultet u Novom Sadu, 2017. http://www.cris.uns.ac.rs/record.jsf?recordId=104332&source=NDLTD&language=en.

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Raloksifen je predstavnik selektivnih modulatora estrogenih receptora koji se koristi u terapiji osteoporoze i invazivnog oblika raka dojke u postmenopauzi. Raloksifen se relativno dobro resorbuje iz gastrointestinalnog trakta, ali pri prvom prolasku kroz jetru podleže biotransformaciji u značajnom procentu, &scaron;to je uzrok njegove niske biolo&scaron;ke raspoloživosti. Bioraspoloživost kod ljudi iznosi 2%, a kod Wistar pacova 39%. Različite supstance se koriste da bi se pobolj&scaron;ala bioraspoloživost lekova. Žučne kiseline, kao &scaron;to je deoksiholna kiselina, omogućavaju bolji prol
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17

Machado, Carla da Silva. "Efeito da medida pré-operatória de força da musculatura respiratória no resultado do transplante de fígado." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/5/5160/tde-20072007-103950/.

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INTRODUÇÃO: Em pacientes com doença hepática avançada, pode ocorrer diminuição das pressões inspiratória máxima (PImáx) e expiratória máxima (PEmáx), respectivamente. Nos pacientes submetidos a transplante de fígado (Tx) essas alterações são agravadas no pós-operatório imediato. Para nosso conhecimento, a importância da medida pré-operatória da força da musculatura respiratória na evolução pós-operatória ainda não foi investigada no Tx. OBJETIVO: Avaliar o efeito das medidas pré-operatórias de força da musculatura respiratória no resultado do Tx. MÉTODO: Foram estudados retrospectivamente 228
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18

Željka, Savić. "Uticaj statusa vitamina D na metaboličku aktivnost kosti i koštanu masu kod bolesnika sa alkoholnom cirozom jetre." Phd thesis, Univerzitet u Novom Sadu, Medicinski fakultet u Novom Sadu, 2014. https://www.cris.uns.ac.rs/record.jsf?recordId=89494&source=NDLTD&language=en.

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Uvod: Hepatička osteodistrofija je termin koji obuhvata metaboličke bolesti kosti udružene sa hroničnim bolestima jetre. U alkoholnoj cirozi (AC) jetre postoji visoka zastupljenost deficijencije vitamina D proporcionalna stepenu disfunkcije jetre, ali njena uloga u patogenezi hepatičke osteodistrofije nije dovoljno obja&scaron;njena. Nivo 25(OH)D odražava status vitamina D. Kod AC jetre izmenjena je metabolička aktivnost kosti i suprimirano je formiranje kosti &scaron;to dovodi do smanjenja ko&scaron;tane mase. U centru interesovanja je postizanje optimalnog statusa vitamina D. Stavovi o suple
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19

Balzan, Silvio Márcio Pegoraro. "Avaliação de critério pós-operatório de insuficiência hepática como fator prognóstico de mortalidade após hepatectomia: importância da alteração combinada do tempo de protrombina e da bilirrubina sérica." Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/5/5154/tde-29012007-170755/.

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INTRODUÇÃO. A definição de insuficiência hepática pós-operatória (IHP) não é ainda padronizada, dificultando a comparação de inovações em procedimentos hepáticos e tornando complexo o uso de possíveis intervenções terapêuticas pós- operatórias em um momento adequado. CASUÍSTICA E MÉTODOS. Entre 1998 e 2002, 775 resecções hepáticas eletivas, dos quais 531 (69%) por doenças malignas e 464 (60%) consistindo em hepatectomias maiores, foram incluídas de maneira prospectiva em um banco de dados. O parênquima hepático não-tumoral foi anormal em 330 pacientes (43%) incluindo esteatose em mais que 30%
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20

Kajiwara, Keita. "Level of endotoxin and liver function tests in cases of equine colic." Thesis, 1996. http://hdl.handle.net/1957/33961.

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21

Pereira, Rosa Carolina Gonçalves. "Abdominal ultrasound yield in critical care patients with liver function tests abnormalities." Master's thesis, 2018. https://hdl.handle.net/10216/114278.

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Introdução: A expressão "Testes de Função Hepática" é comumente usada como referência a componentes da análise bioquímica do fígado - ALT; AST; G-GT; Fosfatase Alcalina; Bilirrubina. Alterações nestes 5 parâmetros são frequentes em Medicina Intensiva, levando a um aumento da procura e gastos com testes diagnósticos imagiológicos. Objetivo: analisar os resultados das ecografias abdominais pedidas por alterações dos Testes de Função Hepática em doentes críticos. Materiais e Métodos: Análise retrospetiva unicêntrica de todos os pedidos de ecografias abdominais, do Serviço de Medicina Intensiva,
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22

Pereira, Rosa Carolina Gonçalves. "Abdominal ultrasound yield in critical care patients with liver function tests abnormalities." Dissertação, 2018. https://repositorio-aberto.up.pt/handle/10216/114278.

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Introdução: A expressão "Testes de Função Hepática" é comumente usada como referência a componentes da análise bioquímica do fígado - ALT; AST; G-GT; Fosfatase Alcalina; Bilirrubina. Alterações nestes 5 parâmetros são frequentes em Medicina Intensiva, levando a um aumento da procura e gastos com testes diagnósticos imagiológicos. Objetivo: analisar os resultados das ecografias abdominais pedidas por alterações dos Testes de Função Hepática em doentes críticos. Materiais e Métodos: Análise retrospetiva unicêntrica de todos os pedidos de ecografias abdominais, do Serviço de Medicina Intensiva, d
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23

Wang, Yue-Chi, and 王悅琪. "Liver Function Tests and Therapeutic Drug Monitoring in Schizophrenic Patients on Quetiapine Combination Therapy." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/88394740069521616582.

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碩士<br>臺北醫學大學<br>藥學研究所<br>96<br>It was reported that quetiapine (QTP)-treated patients presented asymptomatic liver dysfunction and new-onset diabetes mellitus. It was also shown that QTP treatment may change metabolic parameters of schizophrenic patients with or without hyperglycemia differently. Blood glucose controls of oral antidiabetics may be improved while diabetic patients co-medicated with silymarin (SB). The purpose of this study was to monitor the liver function changes and therapeutic drug concentrations after QTP treatments, and after QTP co-medicated with SB treatments in Taiwanes
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24

Madlala, Hlengiwe Pretty. "The effects of plant-derived oleanolic acid on kidney function in male Sprague-Dawley rats and, in cell lines of the kidney and liver." Thesis, 2012. http://hdl.handle.net/10413/6046.

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Adverse effects and increasing cost of therapeutic drugs have renewed an interest in the use of medicinal plant products for the treatment of a variety of chronic disorders. One such bioactive plant-derived compound is a pentacyclic triterpenoid, oleanolic acid (3ß-hydroxy-olea-12-en-28- oic acid, OA) present in herbs. OA possesses a variety of pharmaceutical activities and of interest in this study are the anti-diabetic properties. Diabetes is associated with disorders grouped as microvascular (retinopathy and nephropathy) and macrovascular (atherosclerotic) complications. Accordingly, this s
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25

Duque, Mariana Simões. "Early Assessment of Liver Functional Reserve with Gd-EOB-DTPA enhanced MRI in patients undergoing Major Hepatectomy after PVE - Is Function More Relevant Than Volume?" Master's thesis, 2018. http://hdl.handle.net/10316/82010.

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Trabalho Final do Mestrado Integrado em Medicina apresentado à Faculdade de Medicina<br>Introdução: A avaliação da reserva funcional hepática é crucial antes de uma hepatectomia major, particularmente se a embolização da veia porta (PVE) for necessária, uma vez que estes doentes apresentam maior risco de insuficiência hepática pós-hepatectomia (PHLF). Dado que a resposta funcional à PVE ocorre antes das alterações volumétricas do fígado remanescente (FLR), a Ressonância Magnética (MRI) com contraste hepato-específico, nomeadamente o gadolínio etoxibenzil dimeglumine (Gd-EOB-DTPA), revela-se pr
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26

Fidlerová, Karolína. "Domácí parenterálná výživa v denním a nočním režimu." Master's thesis, 2021. http://www.nusl.cz/ntk/nusl-447905.

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This diploma thesis deals with home parenteral nutrition in the day and night regime and its effect on patients. Parenteral nutrition is usually administered at night so that patients can do normal daily activities and so that nutrition administered in this way has the least impact on their lives. Parenteral nutrition is not a physiological route of nutrient administration and it is not natural for the human body to process nutrients at night. The first part of the theoretical work presents parenteral nutrition and its composition, indications, contraindications and complications. The next par
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