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Journal articles on the topic 'Liver marker enzymes'

Author: Grafiati

Published: 3 June 2025

Last updated: 1 August 2025

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1

Contreras-Zentella, Martha Lucinda, and Rolando Hernández-Muñoz. "Is Liver Enzyme Release Really Associated with Cell Necrosis Induced by Oxidant Stress?" Oxidative Medicine and Cellular Longevity 2016 (2016): 1–12. http://dx.doi.org/10.1155/2016/3529149.

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Hepatic diseases are a major concern worldwide. Increased specific plasma enzyme activities are considered diagnostic features for liver diseases, since enzymes are released into the blood compartment following the deterioration of the organ. Release of liver mitochondrial enzymes is considered strong evidence for hepatic necrosis, which is associated with an increased production of ROS, often leading to greater hepatic lipid peroxidation. Lipotoxic mediators and intracellular signals activated Kupffer cells, which provides evidence strongly suggesting the participation of oxidant stress in ac

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2

Thirugnanam, Siva Sankari, and Subashini Ragunathan. "Hepatoprotective Potential of Esculetin Loaded Chitosan Nanoparticles (ESC-CNPs) in DMBA- Induced Mammary Carcinogenesis in Sprague-Dawley Rats." UTTAR PRADESH JOURNAL OF ZOOLOGY 45, no. 23 (2024): 133–47. https://doi.org/10.56557/upjoz/2024/v45i234694.

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The hepatoprotective effects of Esculetin Loaded Chitosan Nanoparticles (ESC-CNPs) were assessed in this work using a model of 7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary carcinogenesis. DMBA (25 mg/rat) was injected subcutaneously once close to the mammary gland in Sprague-Dawley rats to cause mammary tumors. To find the ideal dose, several ESC-CNPs concentrations were taken orally. The evaluation of hepatoprotective effects involved the examination of liver marker enzymes (AST, ALT and ALP), enzymatic antioxidants (SOD, CAT, and GPx), and non-enzymatic antioxidants GSH, lipid perox

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3

Nasiruddin, Mohammad, Irfan Ahmad Khan, and Sayeedul Hasan Arif. "THERAPEUTIC EFFECT OF NYMPHAEA ALBA LINN. FLOWERS AGAINST ISONIAZID-INDUCED HEPATOTOXICITY: AN EXPERIMENTAL STUDY." Asian Journal of Pharmaceutical and Clinical Research 11, no. 5 (2018): 333. http://dx.doi.org/10.22159/ajpcr.2018.v11i5.22830.

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Objective: This study was designed to evaluate the effect of ethanolic extract of Nymphaea alba (NAEE) Linn. flowers on liver marker enzymes, histology, and antioxidant tests against isoniazid (INH)-induced hepatotoxicity in rats.Methods: Wistar albino rats were treated with INH (50 mg/kg) for 28 days to induce hepatotoxicity. Silymarin (100 mg/kg) and NAEE Linn flowers in 200 mg/kg and 400 mg/kg doses, respectively, were used as standard and test drugs. Liver marker enzymes and histological examination of livers were performed to demonstrate the effect of NAEE against INH-induced hepatotoxici

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4

Danpure, C. J., P. Purkiss, P. R. Jennings, and R. W. E. Watts. "Mitochondrial damage and the subcellular distribution of 2-oxoglutarate:glyoxylate carboligase in normal human and rat liver and in the liver of a patient with primary hyperoxaluria type I." Clinical Science 70, no. 5 (1986): 417–25. http://dx.doi.org/10.1042/cs0700417.

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1. The subcellular distribution of 2-oxoglutarate:glyoxylate carboligase was investigated in a normal human liver, a liver from a patient with pyridoxine-resistant primary hyperoxaluria type I and rat livers subjected to various degrees and types of trauma. 2. On continuous sucrose gradients most of the carboligase fractionated with a peak equilibrium density of 1.19–1.20 g/cm3 and paralleled the distribution of the major peaks of monoamine oxidase, glutamate dehydrogenase and cytochrome oxidase and can be considered to be mitochondrial. Various proportions of the carboligase and mitochondrial

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5

Suchy, F. J., S. M. Courchene, and B. L. Blitzer. "Taurocholate transport by basolateral plasma membrane vesicles isolated from developing rat liver." American Journal of Physiology-Gastrointestinal and Liver Physiology 248, no. 6 (1985): G648—G654. http://dx.doi.org/10.1152/ajpgi.1985.248.6.g648.

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Taurocholate transport was characterized in basolateral plasma membrane vesicles prepared from the livers of 14-day-old Sprague-Dawley rats using a self-generating Percoll gradient method. Liver plasma membrane protein yield, intravesicular volume, and enrichments of various marker enzymes were similar to those obtained for vesicles from adult rat liver. The basolateral marker enzyme Na+-K+-ATPase was enriched 26-fold in the suckling rat basolateral membrane fraction while the bile canalicular marker enzymes alkaline phosphatase and Mg2+-ATPase were enriched only 3- and 5-fold, respectively. T

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6

Vijay, Ganesh, and Modi Poornima. "Acute hepatitis in children: A wide clinical spectrum." GSC Biological and Pharmaceutical Sciences 29, no. 2 (2024): 001–7. https://doi.org/10.5281/zenodo.14738302.

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<strong>Introduction</strong>: Acute hepatitis remains an important health problem in children. viral hepatitis particularly hepatitis A remains the most common cause. Nevertheless, other causes such as non A non B hepatitis and mixed infections like enteric fever are other causes particularly in developing countries like India. The spectrum of acute hepatitis is also varied with many atypical presentations in the form of fever along with icterus as presenting features. Use of lab parameters as prognostic markers for development of acute liver failure (ALF) needs further exploration as it can

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7

S, Karthikeyan, Sureshkumar P, Dinakaran C, Chezhian A, and P. Soundarapandian. "Impact of Ocean Acidification on Marker Enzymes in Asian Seabass Lates Calcarifer (Bloch)." UTTAR PRADESH JOURNAL OF ZOOLOGY 45, no. 23 (2024): 1–9. https://doi.org/10.56557/upjoz/2024/v45i234681.

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Backgrounds: The influence of ocean acidification (OA) is particularly significant on calcifying organisms in marine environment. A possible explanation for acidification-induced changes in fish behaviour is that acidification interferes with marker enzymes in the liver, muscle and brain. Under a range of severe environmental circumstances, marine organisms can be susceptible to oxidative stress and results in the changes in the biochemical components which can be assessed to know the health status of organisms. Aim of the Works: The aim of this study is to observe the impact of ocean acidific

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8

Koenig, Sarah, Hendryk Aurich, Christian Schneider, et al. "Zonal expression of hepatocytic marker enzymes during liver repopulation." Histochemistry and Cell Biology 128, no. 2 (2007): 105–14. http://dx.doi.org/10.1007/s00418-007-0301-y.

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9

Gierow, P., and B. Jergil. "Heterogeneity of smooth endoplasmic reticulum from rat liver studied by two-phase partitioning." Biochemical Journal 262, no. 1 (1989): 55–61. http://dx.doi.org/10.1042/bj2620055.

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Smooth microsomal membranes, prepared from rat liver by sucrose-density-gradient centrifugation, were subfractionated by counter-current distribution in an aqueous two-phase system consisting of poly(ethylene glycol) and Dextran T500. A comparison of the distribution curves of marker enzymes, together with theoretically calculated curves, indicated the presence of at least five membrane subfractions, differing in the ratios of the marker enzymes. Glucose-6-phosphatase and arylesterase distributed in one manner, and NADPH-cytochrome c reductase and NADH-ferricyanide reductase in another. Eviden

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10

Khither, Hanane, Soraya Madoui, Selma Houchi, and Asma Mosbah. "Hepatocurative potential of Thymoquinone against CCl4-Induced Hepatotoxicity: impact on antioxidant defense systems in rat liver and plasma." Brazilian Journal of Animal and Environmental Research 7, no. 4 (2024): e75872. https://doi.org/10.34188/bjaerv7n4-135.

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This study evaluates the oxidative stress markers in a CCl4-induced hepatotoxicity model in rats and explores the hepatoprotective effects of Thymoquinone (TQ). The oxidative stress markers analyzed include Catalase (CAT) and Superoxide Dismutase (SOD) as enzyme markers, and Glutathione (GSH) and Malondialdehyde (MDA) as non-enzyme markers. These markers were assessed in both liver homogenate and plasma levels. CCl4 exposure significantly increased MDA levels, a marker of lipid peroxidation, and decreased GSH, reflecting severe oxidative stress and liver damage. Enzyme activities of CAT and SO

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11

Saxena, Sneha, Lata Shahani, and Pradeep Bhatnagar. "HEPATOPROTECTIVE EFFECT OF CHENOPODIUM QUINOA SEED AGAINST CCL4-INDUCED LIVER TOXICITY IN SWISS ALBINO MALE MICE." Asian Journal of Pharmaceutical and Clinical Research 10, no. 11 (2017): 273. http://dx.doi.org/10.22159/ajpcr.2017.v10i11.20918.

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Objective: To study the effect of Quinoa seed on carbon tetrachloride (CCL4)-induced liver toxicity in Swiss albino male mice.Methods: Swiss albino male mice were divided into three groups: Group 1 served as control group; Group 2 served as hepatotoxic group (CCl4 treated); and Group 3 served as combination of Quinoa seed powder (20 mg/kg) + CCl4-treated group. The effect of these groups on liver tissue was studied after three different periods of 4, 8, and 12 weeks. Liver marker enzyme level of serum glutamic-oxaloacetic transaminase, serum glutamic-pyruvic transaminase, serum alkaline phosph

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12

Gogoi, Nabajyoti, Ankur Gogoi, Bijoy Neog, and Khumanthem Deepak Singh. "Hepatoprotective effect of Garcinia xanthochymus and Garcinia lanceifolia against carbon tetrachloride-induced hepatic damage in rat." Bangladesh Journal of Pharmacology 18, no. 3 (2023): 91–96. https://doi.org/10.3329/bjp.v18i3.65992.

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Garcinia xanthocymus and Garcinia lanceifolia fruit extracts (200 or 400 mg/kg in each plant) were used to evaluate the hepatoprotective activity in albino rats. The carbon tetrachloride-intoxicated group initially elevated the liver marker enzymes (serum aminotransferases, alkaline phosphatase) and bilirubin. Total protein production was suppressed. When extracts were administered orally, it lowered the level of liver marker enzymes, bilirubin and elevated the production of protein. The histopathological findings supported the hepatoprotective activity of both extracts at tissue level. In con

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13

SHIMAA, A. B. D., S. A. E. EL-SAYED, and M. A. RIZK. "Significance of selected biochemical markers in predicting the outcome of schistosomiasis." Journal of the Hellenic Veterinary Medical Society 69, no. 1 (2018): 739. http://dx.doi.org/10.12681/jhvms.16397.

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This study aimed to correlate the histopathological changes in mice liver with alterations either in liver tissue antioxidants enzymes (catalase and reduced glutathione (GSH)), oxidative stress marker (malondialdehyde (MDA)) or in serum liver function parameters (Alanine aminotransferase (ALT), aspartate aminotransferase (AST), total protein (T.P.) and albumin) to predict the outcome of schistosomiasis. Fourty male Swiss albino mice were used in this study and infected with Schistosoma mansoni for 2, 4, 6 and 8 weeks (8 mice for each group), while, the uninfected mice were used as negative con

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14

G., Thiyagarajan, S. Gowtham Kumar A., Ramakrishnan V., Madhusudhanan N., and Anbu Selvam C. "Therapeutic Efficacy of Allyl Isothiocyanate Evaluated on N-Nitrosodiethylamine/Phenobarbitol induced Hepatocarcinogenesis in Wistar Rats." Journal of Advanced Laboratory Research in Biology 1, no. 1 (2010): 05–09. https://doi.org/10.5281/zenodo.1314087.

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N-nitrosodiethylamine (NDEA) is a potential carcinogenic agent that induces liver cancer. To evaluate the chemotherapeutic effect of Allyl isothiocyanate in the experimental model, Wistar male rats were administered single dose of intraperitoneal (IP) injection of NDEA. Two weeks after administration of NDEA, Phenobarbital at the concentration of 0.05% was incorporated in rat chow for up to 14 successive weeks to promote liver cancer. Allyl isothiocyanate (AITC) (2mg/kg body weight) in addition with 0.5ml of corn oil was given orally on a daily basis. At the end of this experimental period, th

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15

Binil, Eldhose, Kuriakose Jayesh, and Latha Mukalel Sankunni. "Curative effect of Plumbago indica root extract on thioacetamide induced hepatotoxicity in experimental rats." International Journal of Phytomedicine 9, no. 1 (2017): 138. http://dx.doi.org/10.5138/09750185.1980.

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<p>The root parts of <em>Plumbago indica</em> is widely used in the Indian Ayurvedic traditional system. The study was designed to evaluate the hepato curative activity Plumbago<em> Indica</em> (PLBM) methanolic root extracts at different doses (100 and 200 mg/kg bw) against thioacetamide induced liver damage in albino wistar rats. Liver damage was induced by administration of Thioacetamide (100 mg/kg bw) and was assessed by evaluating the activity of liver-function marker enzymes, antioxidant enzymes and lipid peroxidation. The liver sections were evaluated for h

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16

Bonam, Venkata Ramesh, P. Supriya, and Pedda P. Reddamma. "INSULIN RESISTANCE AND HEPATIC MARKERS IN TYPE 2 DIABETES MELLITUS: A CROSS-SECTIONAL STUDY." Eastern Ukrainian Medical Journal 12, no. 4 (2024): 886–91. https://doi.org/10.21272/eumj.2024;12(4):886-891.

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Aim: The objective of this study was to compare liver markers and insulin resistance between diabetic and non-diabetic individuals and determine the correlation between diabetic and non-diabetic parameters. Methods: A cross-sectional study was conducted at the Department of Biochemistry after being approved by the Institutional Ethics Committee. Fasting venous blood was collected for serum analysis of various biochemical parameters, including liver enzymes AST and ALT. Total and direct bilirubin and plasma proteins like total protein, albumin, globulin, A:G ratio were assessed using automated

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17

Dr., G. Nagaraju, V.Sirisha, Ramakrishna Kavati, and Hareesh Dara Dr. "PHYTO CHEMICAL AND PHARMACOLOGICAL EVALUATION OF MENTHA ARVENSIS LEAVES EXTRACT ON THIOACETAMIDE-INDUCED LIVER DAMAGE IN RATS TO DETERMINE HEPATO-PROTECTIVE ACTIVITY." Journal of Pharma Research 5, no. 12 (2016): 298–303. https://doi.org/10.5281/zenodo.14233137.

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<strong>Abstract</strong> <strong>E</strong>xperiments were designed to establish the hepatoprotective activity of Mentha Arvensis (EMAL) ethanolic Leaves extracts at different doses (100 and 200 mg/kg bw) against thioacetamide-induced liver damage in albino Wistar rats. Hepatotoxicity was assessed by evaluating the activity of liver-function marker enzymes such as aspartate transaminase, alanine transaminase, alkaline phosphatase and lactate dehydrogenase as well as antioxidant enzymes such as catalase, glutathione peroxidase, glutathione reductase, glutathione-S-transferase and reduced gluta

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18

QUINTART, Joel, Pierre BAUDHUIN, and Pierre J. COURTOY. "Marker enzymes in rat liver vesicles involved in transcellular transport." European Journal of Biochemistry 184, no. 3 (1989): 567–74. http://dx.doi.org/10.1111/j.1432-1033.1989.tb15051.x.

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19

Kovalszky, Ilona, Zsuzsa Schaff, Károly Lapis, and András Jeney. "Marker enzymes of rat chemical hepatocarcinogenesis in human liver tumors." Pathology & Oncology Research 2, no. 1-2 (1996): 56–58. http://dx.doi.org/10.1007/bf02893950.

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20

Quistorff, B., N. Grunnet, and N. W. Cornell. "Digitonin perfusion of rat liver. A new approach in the study of intra-acinar and intracellular compartmentation in the liver." Biochemical Journal 226, no. 1 (1985): 289–97. http://dx.doi.org/10.1042/bj2260289.

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Perfusing a rat liver with digitonin in the concentration range 2-20 mg/ml results in complete decolorization of the organ within 45-250 s. Decolorization progresses with time in the direction of flow, and it is therefore possible, by collecting the eluate, to obtain material from specific intracellular compartments of hepatocytes in different zones in the microcirculatory unit of the liver. The results demonstrate that cytoplasmic marker enzymes from periportal or perivenous hepatocytes can be collected with as little contamination from the other compartment as is obtained in micro-dissection

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21

Ruoß, Marc, Georg Damm, Massoud Vosough, et al. "Epigenetic Modifications of the Liver Tumor Cell Line HepG2 Increase Their Drug Metabolic Capacity." International Journal of Molecular Sciences 20, no. 2 (2019): 347. http://dx.doi.org/10.3390/ijms20020347.

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Although human liver tumor cells have reduced metabolic functions as compared to primary human hepatocytes (PHH) they are widely used for pre-screening tests of drug metabolism and toxicity. The aim of the present study was to modify liver cancer cell lines in order to improve their drug-metabolizing activities towards PHH. It is well-known that epigenetics is strongly modified in tumor cells and that epigenetic regulators influence the expression and function of Cytochrome P450 (CYP) enzymes through altering crucial transcription factors responsible for drug-metabolizing enzymes. Therefore, w

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22

Salem, Neveen A., Amal Hamza, Hanan Alnahdi, and Najla Ayaz. "Biochemical and Molecular Mechanisms of Platelet-Rich Plasma in Ameliorating Liver Fibrosis Induced by Dimethylnitrosurea." Cellular Physiology and Biochemistry 47, no. 6 (2018): 2331–39. http://dx.doi.org/10.1159/000491544.

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Background/Aims: Hepatic fibrosis is a wound-healing process in the chronically injured liver. Clinical application of platelet-rich plasma (PRP) is of considerable interest for wound healing and regeneration. In view of the regeneration effect of PRP, we designed this study to explore the hypothesis that PRP could play a role in improving the biochemical and molecular changes that occur in liver fibrosis induced by dimethylnitrosamine (DMN) in rats. Methods: Four groups were studied: control, PRP control, DMN (liver fibrosis), and DMN+PRP groups. Serum liver enzymes (alanine amino transferase

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23

Venkateswararao, Rachumallu, Balasubramanian Arul, and Ramalingam Kothai. "Chemopreventive effects of Costus comosus Linn against diethylnitrosamine-induced hepatocellular carcinoma in rats." Journal of Herbmed Pharmacology 11, no. 3 (2022): 375–82. http://dx.doi.org/10.34172/jhp.2022.43.

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Introduction: Costus comosus is a potential medicinal plant used traditionally to treat various ailments. The present study aimed to evaluate antioxidant status, lipid peroxidation, and the ameliorative effect of its ethanolic leaf extract against diethylnitrosamine (DEN)-induced hepatocellular carcinoma (HCC) in rats. Methods: HCC was induced by 0.01 % v/v DEN through the drinking water for 16 weeks. The animals were treated with ethanolic leaf extract of C. comosus (EECC) at 200 and 400 mg/kg for 16 weeks. In this study, tumour incidence, tumour volume, tumour burden, lipid peroxidation, ant

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EL-BELTAGI, Hossam S., Faten DHAWI, Ihab S. ASHOUSH, and Khaled RAMADAN. "Antioxidant, anti-cancer and ameliorative activities of Spirulina platensis and pomegranate juice against hepatic damage induced by CCl4." Notulae Botanicae Horti Agrobotanici Cluj-Napoca 48, no. 4 (2020): 1941–56. http://dx.doi.org/10.15835/nbha48412151.

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Due to the excessive impact of synthetic drugs, unravelling and employing safe, natural alternatives are now needed to resolve a number of diseases. In this research, we have evaluated hepatoprotective and antioxidant activities of Spirulina platensis and pomegranate juice in rats against hepatotoxicity induced by carbon tetrachloride (CCl4). Spirulina crude carotenoid extract was screened by UPLC-MS / MS. Activities of liver marker enzymes; measured aspartate aminotransferase (AST) and alanine aminotransferase (ALT), and determined lipid peroxidation and antioxidant status as reduced glutathi

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Fritzson, P., T. B. Haugen, and H. Tjernshaugen. "The presence and activity in normal and regenerating rat liver postmicrosomal supernatant fraction of an enzyme with properties similar to those of membrane-bound 5′-nucleotidase." Biochemical Journal 239, no. 1 (1986): 185–90. http://dx.doi.org/10.1042/bj2390185.

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An alkaline 5′-nucleotidase with properties similar to those of membrane-bound 5′-nucleotidase was recovered in soluble form in the postmicrosomal supernatant fraction (cytosol) of rat liver. The enzyme seems to constitute a quantitatively distinct fraction, since the activity in postmicrosomal supernatants was increased by a further 10% by additional homogenization of livers. Lysosomal acid phosphatase activity increased similarly, whereas other membrane-bound marker enzymes alkaline phosphatase, phosphodiesterase I and glucose-6-phosphatase showed no increase when homogenization of liver tis

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Vijay Ganesh and Poornima Modi. "Acute hepatitis in children: A wide clinical spectrum." GSC Biological and Pharmaceutical Sciences 29, no. 2 (2024): 001–7. http://dx.doi.org/10.30574/gscbps.2024.29.2.0401.

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Introduction: Acute hepatitis remains an important health problem in children. viral hepatitis particularly hepatitis A remains the most common cause. Nevertheless, other causes such as non A non B hepatitis and mixed infections like enteric fever are other causes particularly in developing countries like India. The spectrum of acute hepatitis is also varied with many atypical presentations in the form of fever along with icterus as presenting features. Use of lab parameters as prognostic markers for development of acute liver failure (ALF) needs further exploration as it can be used to identi

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27

Jose, Svenia P., M. Ratheesh, S. Asha, IM Krishnakumar, S. Sandya, and Kumar B. Girish. "Hepato-protective Effect of Clove Bud Polyphenols (Syzygium aromaticum L.) (Clovinol®) by Modulating Alcohol Induced Oxidative Stress and Inflammation." Journal of Food Research 7, no. 1 (2017): 10. http://dx.doi.org/10.5539/jfr.v7n1p10.

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The pathogenesis of alcoholic liver diseases progresses from fatty liver to hepatic inflammation and necrosis to fibrosis. Clove buds (Syzygium aromaticum L.) are one of the richest sources of dietary polyphenols with many traditional medicinal uses. Hence, the present work attempted to evaluate the hepatoprotective activity of a standardized polyphenol-rich extract of clove buds (Clovinol). The experiment was conducted on Wistar rats designated into three groups. First group was vehicle control and hepatotoxicity was induced to the second group by the administration of ethanol at the fixed do

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Hassan, Sherif Sabry, Ahmer Razzaque, Zulfiqar Ahmad, Vanessa Pazdernik, and Shaimaa Nasr Amin. "Does posttreatment thymoquinone reverse high-dose atorvastatin-induced hepatic oxidative injury in rats?" Canadian Journal of Physiology and Pharmacology 96, no. 1 (2018): 51–59. http://dx.doi.org/10.1139/cjpp-2017-0599.

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Atorvastatin (ATO) was commonly used to lower blood cholesterol, but it caused harmful effects to organs, including the liver. Thymoquinone (TQ), a prominent constituent of Nigella sativa, has antioxidant, antiinflammatory, antiapoptotic, antimicrobial, and anticancer activity. The current study investigated the mechanism of ATO-induced hepatotoxicity, whether posttreatment TQ could reverse ATO-induced hepatic injury, and the mechanism of action of TQ as a hepatoprotective agent. Forty adult male Sprague Dawley rats were divided into four equal groups: control, TQ-treated, ATO-treated, and com

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Adamus, Jakub Piotr, Anna Ruszczyńska, and Aleksandra Wyczałkowska-Tomasik. "Molybdenum’s Role as an Essential Element in Enzymes Catabolizing Redox Reactions: A Review." Biomolecules 14, no. 7 (2024): 869. http://dx.doi.org/10.3390/biom14070869.

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Molybdenum (Mo) is an essential element for human life, acting as a cofactor in various enzymes crucial for metabolic homeostasis. This review provides a comprehensive insight into the latest advances in research on molybdenum-containing enzymes and their clinical significance. One of these enzymes is xanthine oxidase (XO), which plays a pivotal role in purine catabolism, generating reactive oxygen species (ROS) capable of inducing oxidative stress and subsequent organ dysfunction. Elevated XO activity is associated with liver pathologies such as non-alcoholic fatty liver disease (NAFLD) and h

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Sani, Muhammad Bappah, Hamza Ahmed Pantami, Nura Abubakar, et al. "Metabolite Profile, Antioxidant Activity and Ameliorative Efficacy of Diospyros Mespiliformis on Carbon Tetrachloride (CCL4) Induced Oxidative-Stress in Albino Mice." Semarak Current Biomedical Technology Research Journal 4, no. 1 (2025): 41–67. https://doi.org/10.37934/scbtrj.4.1.4167.

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Liver diseases are deadly and requires continuous medication, conventional treatment is harmful and expensive, so there need for hepatoprotective remedy from plant sources. Bioactive phytochemicals were profiled and the efficacy of Diospyros mespiliformis (DM) stem-bark extracts was evaluated against carbon tetrachloride (CCL4) induced oxidative stress in mice. Diospyros mesopiliformis have been reported for various activities such as antioxidant, antimicrobial, antiiflammatory. Based on the previous reports it was anticipated D. mesopiliformis will ameliorate CCL4 induced liver damage in muri

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Sani, Muhammad Bappah, Hamza Ahmed Pantami, Nura Abubakar, et al. "Metabolite Profile, Antioxidant Activity and Ameliorative Efficacy of Diospyros Mespiliformis on Carbon Tetrachloride (CCL4) Induced Oxidative-Stress in Albino Mice." Semarak Current Biomedical Technology Research Journal 4, no. 1 (2025): 41–67. https://doi.org/10.37934/scbtrj.4.1.4167b.

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Liver diseases are deadly and requires continuous medication, conventional treatment is harmful and expensive, so there need for hepatoprotective remedy from plant sources. Bioactive phytochemicals were profiled and the efficacy of Diospyros mespiliformis (DM) stem-bark extracts was evaluated against carbon tetrachloride (CCL4) induced oxidative stress in mice. Diospyros mesopiliformis have been reported for various activities such as antioxidant, antimicrobial, antiiflammatory. Based on the previous reports it was anticipated D. mesopiliformis will ameliorate CCL4 induced liver damage in muri

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32

Anushiravani, Amir, Bardia Khosravi, Bahar Saberzadeh-Ardestani, et al. "A Reliable Prognostic Marker for Liver Dysfunction in COVID-19 Infection." Middle East Journal of Digestive Diseases 13, no. 3 (2021): 193–99. http://dx.doi.org/10.34172/mejdd.2021.225.

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BACKGROUND In December 2019, COVID-19 emerged from China and spread to become a pandemic, killing over 1,350,000 up to November 18, 2020. Some patients with COVID-19 have abnormal liver function tests. We aimed to determine the clinical significance of liver chemistries in patients with COVID-19. METHODS We performed a cross-sectional study of 1044 consecutive patients with confirmed COVID-19 in two referral hospitals in Tehran, Iran, from February to April 2020. All cases were diagnosed by clinical criteria and confirmed by characteristic changes in the spiral chest computed tomography (CT) a

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Ullah, Manzoor, Sultan Mehmood, Rehmat Ali Khan, et al. "Assessment of Antidiabetic Potential and Phytochemical Profiling of Viscum album, a Traditional Antidiabetic Plant." Journal of Food Quality 2022 (August 4, 2022): 1–9. http://dx.doi.org/10.1155/2022/5691379.

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The traditional antidiabetic plant Viscum album (V. album) was collected from the oak plant in the wild at Maidan, Khyber District, of Pakistan, for assessment of its antidiabetic potential and phytochemical profile. Lowering of blood glucose level, antioxidant effect, lipids proﬁle, liver function marker enzymes, and kidney function markers were evaluated in extract and glibenclamide treated groups, in normal as well as in diabetic control groups. An elevated level of blood glucose level, lipids (Cholesterol, TG, LDL), liver function marker enzymes (ALT, AST, ALP), and kidney function markers

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Ezeji, E. U., O. Obidua, I. G. Kalu, and I. N. Nwachukwu. "Effect of Gari Diet on Marker Enzymes of Mice Liver Mitochondria." Pakistan Journal of Nutrition 8, no. 4 (2009): 414–18. http://dx.doi.org/10.3923/pjn.2009.414.418.

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Aizaz, Fatima, Singh Jaidev, Tiwari Surya, and Imran Khan Mohammed. "Study of Correlation between Proinflammatory Cytokines and Stress marker enzymes in Alcoholic Liver Disease Patients." International Journal of Pharmaceutical and Clinical Research 16, no. 2 (2024): 575–79. https://doi.org/10.5281/zenodo.11071191.

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<strong>Background:</strong> Alcohol-related liver disease is a major cause of morbidity and mortality worldwide. Chronic alcohol consumption leads to hepatocellular injury, fat accumulation and liver inflammation. Progression of ALD is well characterized and is actually a spectrum of liver diseases, which ranges initially from simple steatosis to inflammation and necrosis (steatohepatitis), to fibrosis and cirrhosis. <strong>Objectives:</strong> The study was designed to determine the effect of Pro-inflammatory cytokines & stress marker enzymes in alcoholic liver disease pa

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Maha, D. Azeez* Zahraa M. Mahdi. "Assessment Inflammatory Marker And Its Relationship With Liver Enzymes In Patients With Chronic Liver Failure." International Journal in Pharmaceutical Sciences 2, no. 5 (2024): 373–77. https://doi.org/10.5281/zenodo.11162139.

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<strong>Background: </strong> Keeping the body's metabolic rate in check is one of the liver's most important functions, and the organ's capacity to control its own size is fundamental to good health. However, liver damage from different causes can have serious effects on its function, leading to inflammation, damage to liver cells, and other complications.  So this study aimed to assessment the inflammatory marker and its relationship with liver enzymes. <strong>Materials and method</strong>: Researchers at Al-Hussein Teaching Hospital in Thi-Qar Governorate evaluated chronic liver failu

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Xu, Feng, Xiaolin Liu, Chao Wang, and Chaoliu Dai. "Prostaglandin E1 Preconditioning Attenuates Liver Ischemia Reperfusion Injury in a Rat Model of Extrahepatic Cholestasis." BioMed Research International 2018 (2018): 1–11. http://dx.doi.org/10.1155/2018/3812424.

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The aim of this study is to explore the hepatoprotective effect of intraportal prostaglandin E1 (PGE1) on liver ischemia reperfusion (IR) injury using an extrahepatic cholestatic model, observing oxidative stress markers, proinflammatory factors, apoptotic marker proteins, and an adhesion molecule. The extrahepatic cholestatic model was induced by common bile duct ligation. After seven days, rats were subjected to ischemia by Pringle maneuver for 15 min, followed by 1, 6, or 24 h of reperfusion. Prostaglandin E1 (PGE group) or normal saline (NS group) was continuously infused from 15 min befor

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Kumar, Vinay, Ankur Sharma, Lalit Machawal, K. Nagarajan, and Shadab A. Siddiqui. "Effect of Centella asiatica against anti-tuberculosis drugs-induced hepatotoxicity: Involvement of mitochondria and oxidative stress." Journal of Phytopharmacology 3, no. 5 (2014): 310–15. http://dx.doi.org/10.31254/phyto.2014.3502.

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The liver is an integral organ in the body and plays a vital role for the metabolism of endogenous and exogenous agents. Drug-induced liver toxicity is one of most common cause of liver injury. It accounts for approximately one-half of the cases of acute liver failure and mimics all forms of acute and chronic liver disease. Hepatotoxicity is associated with the first line antituberculosis drugs such as isoniazid and rifampicin. Therefore, there is need of pharmacological interventions for the treatment of hepatotoxicity. The present study was designed to evaluate the hepatoprotective effect of

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Zaar, K., A. Völkl, and H. D. Fahimi. "d-aspartate oxidase in rat, bovine and sheep kidney cortex is localized in peroxisomes." Biochemical Journal 261, no. 1 (1989): 233–38. http://dx.doi.org/10.1042/bj2610233.

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D-Aspartate oxidase (EC 1.4.3.1) was assayed in subcellular fractions and in highly purified peroxisomes from rat, bovine and sheep kidney cortex as well as from rat liver. During all steps of subcellular-fractionation procedures, D-aspartate oxidase co-fractionated with peroxisomal marker enzymes. In highly purified preparations of peroxisomes, the enrichment of D-aspartate oxidase activity over the homogenate is about 32-fold, being comparable with that of the peroxisomal marker enzymes catalase and D-amino acid oxidase. Disruption of the peroxisomes by freezing and thawing released more tha

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Chrostek, Lech, Dagmara Przekop, Ewa Gruszewska, Monika Gudowska-Sawczuk, and Bogdan Cylwik. "Noninvasive Indirect Markers of Liver Fibrosis in Alcoholics." BioMed Research International 2019 (May 5, 2019): 1–9. http://dx.doi.org/10.1155/2019/3646975.

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The aim of this study was to evaluate the diagnostic values of noninvasive indirect markers of liver fibrosis: APRI, GAPRI, Forns, FIB-4, Age-Platelet, and Hepascore in alcoholics. Blood samples were collected from a randomized group of 142 alcohol-dependent patients. The diagnosis of dependency was made according to the ICD-10 WHO criteria. The values of noninvasive markers were calculated with specific algorithms. The fibrosis stage was evaluated on the basis of FibroTest. The values of APRI, Forns, FIB-4, GAPRI, AP, and Hepascore differ between various stages of liver fibrosis. Patients wit

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Suchy, F. J., J. C. Bucuvalas, A. L. Goodrich, M. S. Moyer, and B. L. Blitzer. "Taurocholate transport and Na+-K+-ATPase activity in fetal and neonatal rat liver plasma membrane vesicles." American Journal of Physiology-Gastrointestinal and Liver Physiology 251, no. 5 (1986): G665—G673. http://dx.doi.org/10.1152/ajpgi.1986.251.5.g665.

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The ontogenesis of Na+-K+-ATPase activity and Na+-taurocholate cotransport was studied in basolateral plasma membrane vesicles from fetal and neonatal rat liver. Membrane vesicles from each age group were 30-fold enriched in the basolateral marker enzyme Na+-K+-ATPase, 4- to 7-fold enriched in the bile canalicular membrane marker enzymes alkaline phosphatase and Mg2+ ATPase, and not significantly enriched in activities of marker enzymes for intracellular organelles. Na+-K+-ATPase activity was significantly lower in basolateral membranes from late fetal (day 21–22) and neonatal (day 1) rat live

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Patil, Pallavi N., Ritu M. Gilhotra, Shweta Sharma, and Kiran A. Wadkar. "Hepatoprotective and Antioxidant Activity of Stem and Leaves Parts of Cissus woodrowii (Stapf ex Cooke) Santapau." INTERNATIONAL JOURNAL OF PHARMACEUTICAL QUALITY ASSURANCE 15, no. 02 (2024): 588–94. http://dx.doi.org/10.25258/ijpqa.15.2.05.

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The contemporary investigation aimed to assess the hepatoprotective potential of Cissus woodrowii (Stapf ex Cooke) Santapau against carbon tetrachloride-induced hepatotoxicity. Through evaluating antioxidant levels in liver tissues and blood marker enzymes, it was observed that administration of the plant extract at doses of 200 and 400 mg/kg significantly mitigated liver damage caused by carbon tetrachloride. The study found that carbon tetrachloride-induced reductions in total protein, catalase, glutathione (GSH), and superoxide dismutase (SOD) levels, while increasing levels of alkaline pho

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Yoshihara, Takashi, Tatsuhiko Hamamoto, Ryo Munakata, Ryosuke Tajiri, Mariko Ohsumi, and Sadaki Yokota. "Localization of Cytosolic NADP-dependent Isocitrate Dehydrogenase in the Peroxisomes of Rat Liver Cells." Journal of Histochemistry & Cytochemistry 49, no. 9 (2001): 1123–31. http://dx.doi.org/10.1177/002215540104900906.

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Two types of NADP-dependent isocitrate dehydrogenases (ICDs) have been reported: mitochondrial (ICD1) and cytosolic (ICD2). The C-terminal amino acid sequence of ICD2 has a tripeptide peroxisome targeting signal 1 sequence (PTS1). After differential centrifugation of the postnuclear fraction of rat liver homogenate, approximately 75% of ICD activity was found in the cytosolic fraction. To elucidate the true localization of ICD2 in rat hepatocytes, we analyzed the distribution of ICD activity and immunoreactivity in fractions isolated by Nycodenz gradient centrifugation and immunocytochemical l

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Lee, Sung Hee, Eun Jeong Choi, Ui Jeong Kim, et al. "Synergistic effect of serum uric acid and body mass index trajectories during middle to late childhood on elevation of liver enzymes in early adolescence: Findings from the Ewha Birth and Growth Study." PLOS ONE 18, no. 4 (2023): e0282830. http://dx.doi.org/10.1371/journal.pone.0282830.

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Background/objectives We aimed to determine whether serum uric acid (SUA) and body mass index (BMI) trajectories in childhood have longitudinal association with liver enzymes in adolescence. Methods We conducted a study using data from the Ewha Birth and Growth Cohort. Individual trajectories of SUA (n = 203) and BMI (n = 206) from 5, 7, and 9 years were defined by group-based trajectory modeling. Also, liver function enzymes were collected at 11 to 12 year of age (Aspartate Aminotransferase [AST], Alanine transaminase [ALT], and Gamma-glutamyl transferase [γ–GTP]) (n = 206). Using a generaliz

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Monge, Claudia, Raquel Francés, Agnès Marchio, Pascal Pineau, Christophe Desterke, and Jorge Mata-Garrido. "Characterization of an Activated Metabolic Transcriptional Program in Hepatoblastoma Tumor Cells Using scRNA-seq." International Journal of Molecular Sciences 25, no. 23 (2024): 13044. https://doi.org/10.3390/ijms252313044.

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Hepatoblastoma is the most common primary liver malignancy in children, with metabolic reprogramming playing a critical role in its progression due to the liver’s intrinsic metabolic functions. Enhanced glycolysis, glutaminolysis, and fatty acid synthesis have been implicated in hepatoblastoma cell proliferation and survival. In this study, we screened for altered overexpression of metabolic enzymes in hepatoblastoma tumors at tissue and single-cell levels, establishing and validating a hepatoblastoma tumor expression metabolic score using machine learning. Starting from the Mammalian Metaboli

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Panda, Vandana Sanjeev, Pravin Shivaji Kharat, and S. Sudhamani. "Antioxidant and hepatoprotective effect of Macrotyloma uniflorum seed in antitubercular drug induced liver injury in rats." Journal of Phytopharmacology 4, no. 1 (2015): 22–29. http://dx.doi.org/10.31254/phyto.2015.4105.

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Horse gram [Macrotyloma uniflorum Lam. (Verdc.)] is a lesser known bean consumed as a whole seed or sprout in India. Its seeds are rich in flavonoids and phenolic acids. The protective effect of a hydroalcoholic extract of the seed of Macrotyloma uniflorum (MUSE) in anti-tubercular drug (ATD) induced liver injury and the probable mechanism involved in this protection was investigated in rats. The phenolic acids viz., ferulic and p-coumaric acid were isolated and quantified from MUSE. MUSE (250 mg/kg and 500 mg/kg) and the reference drug Liv.52 (500 mg/kg) was administered orally for 30 days to

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Olakunle Ajiboye, Taofeek. "In vivo antioxidant potentials of Piliostigma thonningii (Schum) leaves: Studies on hepatic marker enzyme, antioxidant system, drug detoxifying enzyme and lipid peroxidation." Human & Experimental Toxicology 30, no. 1 (2010): 55–62. http://dx.doi.org/10.1177/0960327110366785.

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In this study, the in vivo antioxidant potentials of Piliostigma thonningii were investigated in carbon tetrachloride-induced hepatic and oxidative damage in rat. Albino rats were grouped into six, group A rats received sterile distilled water for 14 days while B rats received 0.5 mL/kg body weight of carbon tetrachloride intraperitoneally on day 14. Group C rats received 200 mg/kg body weight of Piliostigma thonningii leaves extract for 14 days. Groups D, E and F rats were pretreated with 50, 100 and 200 mg/kg body weight of Piliostigma thonningii leaves for 14 days and challenged with 0.5 mL

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Sreena, Raj, and M. Gothandam K. "Hepatoprotective and antioxidant activity of aqueous extract of Amorphophallus commutatus var. wayanadensis." Journal of Indian Chemical Society Vol. 92, Apr 2015 (2015): 545–48. https://doi.org/10.5281/zenodo.5596217.

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School of Biosciences and Technology, VIT University, Vellore-632 014, Tamilnadu, India <em>E-mail</em> : gothandam@yahoo.com Amorphophallus commutatus var. wayanadensis is a red listed medicinal plant which has been used traditionally in Wayanad, India for various ailments like hemorrhoids and tumors. The hepatoprotective and antioxidant activity of aqueous extract of Amorphophallus commutatus var. wayanadensis (AEAC) was evaluated against carbon tetrachloride (CCl<sub>4</sub> ) induced hepatotoxicity in swiss albino mice models. Hepatoprotective potential of AEAC was determined by estimating

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Liu, Anding, Hao Jin, Olaf Dirsch, et al. "Release of Danger Signals during Ischemic Storage of the Liver: A Potential Marker of Organ Damage?" Mediators of Inflammation 2010 (2010): 1–11. http://dx.doi.org/10.1155/2010/436145.

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Liver grafts suffer from unavoidable injury due to ischemia and manipulation before implantation. Danger signals such as high-mobility group box -1(HMGB1) and macrophage migration inhibitory factor (MIF) play a pivotal role in the immune response. We characterized the kinetics of their release into the effluent during cold/warm ischemia and additional manipulation-induced mechanical damage. Furthermore, we evaluated the relationship between HMGB1/MIF release and ischemic/mechanical damage. Liver enzymes and protein in the effluent increased with increasing ischemia time. HMGB1/MIF- release cor

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Essa, M. Mohamed, and P. Subramanian. "Pongamia pinnatainfluences the circadian variations of liver marker enzymes in hyperammonemic rats." Biological Rhythm Research 38, no. 6 (2007): 415–20. http://dx.doi.org/10.1080/09291010600981789.

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