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Dissertations / Theses on the topic 'Liver - Pathology'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Kee, Francis. "Molecular pathology of hepatocellular carcinoma." Click to view the E-thesis via HKUTO, 2008. http://sunzi.lib.hku.hk/hkuto/record/b40203785.

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2

Kee, Francis, and 紀思思. "Molecular pathology of hepatocellular carcinoma." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B40203785.

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3

Stanfliet, John Christian. "Evaluation of serum prolidase activity as a marker for liver fibrosis in suspected liver disease." Master's thesis, University of Cape Town, 2011. http://hdl.handle.net/11427/10805.

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Includes bibliographical references (leaves 67-72).<br>Liver dysfunction is common, often unrecognised and likely to increase in incidence in the population in parallel with the obesity and attendant type 2 diabetes mellitus epidemics. Liver fibrosis is a significant finding in liver pathology as it imparts important clinical staging and prognostic information, is a risk marker of adverse clinical outcome yet, even if advanced, is capable of reversal. Histological examination of liver biopsy material is the reference standard in the assessment of liver fibrosis, but it is impractical to biopsy

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4

Stoddard, Michelina Diona. "A Study on Sterile Inflammation in the Zebrafish Liver." Thesis, Weill Medical College of Cornell University, 2019. http://pqdtopen.proquest.com/#viewpdf?dispub=10639271.

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<p> Sterile inflammation (SI), inflammation in the absence of microbial pathogens, is responsible for the morbidity and mortality of millions of Americans every year. Decades of pathologic research have shown that innate immune cells play a critical role in the initiation and resolution of SI; however, researchers do not understand why SI exists or what stimulates this process. A barrier to progress in the field has been the lack of a suitable system with which to image SI intra-vitally. <i>In vitro</i> systems poorly recapitulate complex tissue-level inflammatory responses, and murine models

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5

Delcorde, Julie. "Investigating Host-Viral Interactions in Liver Lipid Homeostasis and HCV Pathology." Thesis, Université d'Ottawa / University of Ottawa, 2014. http://hdl.handle.net/10393/31184.

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Hepatitis C virus (HCV) infects an estimated 170 million people worldwide and is a major cause of chronic hepatitis and hepatocellular carcinoma. As there are limited treatment options, the elucidation of novel host-viral interactions during HCV pathogenesis will be critical for the development of new therapeutics. My thesis work has identified cell death-inducing DFF45-like effector B (CIDEB) as a host factor that is disregulated during HCV infection, and has delineated the relevance of CIDEB’s dual roles in apoptosis and lipid metabolism in the context of the HCV lifecycle. Moreover, additi

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6

Oswald, Douglas Martin. "LOCAL AND SYSTEMIC IMMUNE REGULATION BY LIVER AND PLASMA PROTEIN GLYCOSYLATION." Case Western Reserve University School of Graduate Studies / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=case1575642172980456.

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7

Langman, Gerald. "The role of "non-alcoholic steatohepatitis (NASH)" in methotrexate induced liver injury." Master's thesis, University of Cape Town, 2001. http://hdl.handle.net/11427/3082.

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Includes bibliographical references.<br>Hepatoxicity, especially liver fibrosis. is the major concern with long-term, low-dose oral methotrexate (MTX) therapy for psoriasis. The histological features are nonspecific and may resemble those of nonalcoholic steatohepatitis (NASH). Moreover most of the risk factors of MTX induced liver injury are also associated with NASH. In this study serial liver biopsies of 24 psoriatic patients on lOng-term MTX were investigated to determine whether they had risk factors for NASH and the histological features of a NASH-like pattern of liver injury that could

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8

Thakral, Sharda. "Role of microRNA 122 in Liver Regeneration." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1316390060.

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9

Kalantari, Fariba. "A cellular and molecular approach to investigate pathological calcification in liver /." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=111907.

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The liver is a vital organ, playing numerous critical roles in the body. The liver's ability to perform essential functions is disturbed by injuries that are often associated with many complications such as calcification. Although many reports in the literature document observations of liver calcification, the mechanisms regulating this phenomenon remain unclear. Herein, we aim to investigate the cellular and molecular events that occur during pathological calcification of the liver.<br>To study the mechanisms of calcification, assessments included histological-staining, immunolabeling, and bi

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10

Sonderup, Mark Wayne. "A clinicopathological cohort study of liver pathology in 301 patients with HIV/AIDS." Master's thesis, University of Cape Town, 2013. http://hdl.handle.net/11427/3468.

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11

Davies, John Quail. "Post transplant lymphoproliferative disoders in liver transplant recipients : cases at Red Cross Children's Hospital Cape Town." Master's thesis, University of Cape Town, 2002. http://hdl.handle.net/11427/10375.

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Includes bibliography.<br>Between 1985 and 2000, 43 children (age range 6 months-13 years) underwent liver transplantation at Red Cross Children's Hospital. In 46% of these cases, viral infections resulted in considerable morbidity and mortality. Included in this group were: de novo hepatitis B (5 patients, 2 deaths), EBV-related post-transplantation lymphoproliferative disease (6 patients, 4 deaths) and CMV disease (9 patients, 4 deaths).

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12

Kavanagh, Dean Philip John. "Molecular events governing hematopoietic stem cell recruitment in Vivo in murine liver following Ischemia-reperfusion injury." Thesis, University of Birmingham, 2010. http://etheses.bham.ac.uk//id/eprint/363/.

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Evidence suggests haematopoietic stem cells (HSCs) can migrate to injured liver and influence tissue repair. However, the molecular adhesive mechanisms governing HSC recruitment to injured hepatic microcirculation are poorly understood. These mechanisms were investigated in vivo following murine hepatic ischemia-reperfusion (IR) injury. HSC adhesion was significantly enhanced in injured livers and could be reduced by blocking CD49d on HSCs or VCAM-1 in vivo. Blockade of HSC CD18, CD31 or CD44 did not alter adhesion. HSC adhesion in sham treated CD31-/- animals was raised compared to wild-type

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13

Hayden, Annette Louise. "The role of relaxin in the regulation of human liver and kidney fibrosis." Thesis, University of Southampton, 2009. https://eprints.soton.ac.uk/67633/.

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Liver fibrosis has a range of aetiologies and is a global cause of mortality. A critical effect of liver fibrosis which also increases mortality is portal hypertension. The hepatic stellate cell is accepted as a major progenitor of liver myofibroblasts, which have been shown to be a major source of collagen and extracellular matrix proteins that disrupt liver architecture and function. Relaxin is a hormone involved in remodelling of extracellular matrix in the uterus and cervix and is known to increase renal blood flow in pregnancy. It has been implicated in the regulation of fibrosis in anima

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14

Latham, Patricia S. "The impact of instructional design in a case-based, computer-assisted instruction module on learning liver pathology in a medical school pathology course." Thesis, The George Washington University, 2015. http://pqdtopen.proquest.com/#viewpdf?dispub=3680721.

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<p> The purpose of this quantitative experimental study was to test the impact of three learning interventions on student learning and satisfaction when the interventions were embedded in the instructional design of case-based, Computer-Assisted Instruction (CAI) modules for learning liver pathology in an in-class, self-study, laboratory exercise during a Year-2 medical school Pathology course. The hypothesis was that inclusion of the learning interventions would enhance student satisfaction in using the CAI and improve subsequent CAI-directed exam performance. Three learning interventions we

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15

Asquith, Darren Lee. "The role of the liver X receptors in inflammation : exploring their contribution to articular pathology." Thesis, University of Glasgow, 2010. http://theses.gla.ac.uk/1796/.

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The Liver X receptors, LXRα and LXRβ, belong to the superfamily of nuclear receptor ligand activated transcription factors. LXRs have been well characterised in the context of metabolism through their ability to induce reverse cholesterol transport leading to the excretion of cholesterol from the body. More recently, LXRs have been shown to play a role in inflammation in which they are often ascribed an anti-inflammatory effect. Rheumatoid arthritis (RA) is a chronic auto-immune condition manifest as inflammation of the diarthrodial joints predominantly in the hands and feet. It is now well re

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16

Li, Qi [Verfasser], and Stefan [Akademischer Betreuer] Wölfl. "Functional roles of bone morphogenetic protein-9 in liver pathology / Qi Li ; Betreuer: Stefan Wölfl." Heidelberg : Universitätsbibliothek Heidelberg, 2012. http://d-nb.info/1179785835/34.

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17

Fisher, Leslie Reginald. "Evaluation of high-throughput methodology for multi-gene screening in patients with Non-Alcoholic Fatty Liver Disease (NAFLD)." Thesis, Stellenbosch : Stellenbosch University, 2011. http://hdl.handle.net/10019.1/17896.

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Thesis (MScMedSc)--Stellenbosch University, 2011.<br>ENGLISH ABSTRACT: Non-Alcoholic Fatty Liver Disease (NAFLD) is the most prevalent chronic liver disease in Western countries and is considered the hepatic manifestation of the Metabolic Syndrome (MetS). Its heterogeneous nature ranges from hepatic steatosis through steatohepatitis to advanced fibrosis and cirrhosis where the ingestion of significant amounts of alcohol has been excluded. The disease profile of NAFLD and its necro-inflammatory subset Nonalcoholic Steatohepatitis (NASH) were described in the parent study, which provided a clini

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18

Odeleye, Olalekan Elufisayo. "Lipid peroxidation in the etiology of alcohol liver injury and cancer: Modulatory role of vitamin E." Diss., The University of Arizona, 1991. http://hdl.handle.net/10150/185566.

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The role of increased lipid peroxidation (LP) as the operative mechanism in the early and later stages in the development of alcoholic liver injuries and cancer were investigated. Adult male rats were fed liquid diets containing 36% as ethanol derived calories, with cod liver oil substituting for corn oil, olive oil and cotton seed oil (n-6 fatty acid) for 28 days or 18 months. Control rats received similar diets supplemented with vitamin E. Indices of increased LP including elevated hepatic conjugated dienes, lipid fluorescence, malondialdehyde and ethane exhalation were observed in rats fed

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19

Wiggins, Benjamin George. "Phenotypic and functional characterisation of CD4+ T cells in the human liver." Thesis, University of Birmingham, 2018. http://etheses.bham.ac.uk//id/eprint/8621/.

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The liver has a unique connection with the immune system; harbouring vast numbers of lymphocytes, able to instigate secondary lymphoid organ-independent naive T cell activation, and promoting potent immune tolerance. We set out to determine the effect of this unique microenvironment on the biology of CD4+ T cells at three key interaction points: following migration into the parenchyma, after short-term hepatocyte contact, and at long-term tissue-residency. Modelling transmigration through hepatocytes revealed intrinsic, disease-specific cytokine responses in blood-derived CD4+ T cells, not dis

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20

Hopkins, Laurence Joseph. "On hepatic stem cells and their role in chronic liver disease and carcinogenesis." Thesis, University of Birmingham, 2014. http://etheses.bham.ac.uk//id/eprint/5348/.

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Hepatic stem cells are found in the liver at all stages of development, including adult, and have the potential to give rise to daughter cells of biliary, hepatocytic and pancreatic lineages. Hepatic stem cells contribute significantly to liver regeneration, but may be associated with development of primary liver cancer, and are being investigated as a cellular therapy for liver failure. This thesis describes the development of methods for the immunohistochemical quantification of hepatic stem cell activation, allowing assessment of the association between hepatic stem cell activation in needl

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21

Rezac, Darrel James. "Gross pathology monitoring of cattle at slaughter." Diss., Kansas State University, 2013. http://hdl.handle.net/2097/16386.

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Doctor of Philosophy<br>Department of Diagnostic Medicine/Pathobiology<br>Daniel U. Thomson<br>A series of studies were conducted in order to develop, test, implement, and utilize an objective and comprehensive gross pathology scoring system for cattle at slaughter. Individual lung, liver, and rumen gross pathology data was collected from 19,229 head of cattle and corresponding individual pre-harvest and carcass data for a subset of 13,226 head.. Across the entire population 22.6% and 9.8% of cattle displayed mild and severe lesions, respectively. Severe lung lesions at the time of slaughter

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22

Logan, Patrick 1982. "In vivo imaging of liver metastasis using green fluorescent protein labelled human uveal melanoma cells in a mouse model." Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=112536.

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Uveal melanoma is the most common primary malignant intraocular tumour in adults and despite advances in treatment of the primary tumour, the 10-year survival rate remains unchanged. The most frequent cause of death for patients of this disease is liver metastases. Removal of the primary tumour before clinical presentation of metastases, however, has no effect on patient outcome.<br>In order to understand the interactions between single malignant cells or sub-clinical metastases and affected organs, we have successfully developed a novel animal model of uveal melanoma. We utilized the unique p

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23

Wang, Jian 1961. "Role of tumor-hepatocyte adhesion in carcinoma cell metastasis to the liver." Thesis, McGill University, 1995. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=40275.

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Cell adhesion molecules (CAM) have been implicated in the process of cancer metastasis. However, the interactions of metastatic tumor cells with organ parenchymal cells-hepatocytes particularly the relevance of tumor-cell-hepatocyte adhesion to liver metastasis is still not fully understood. We have investigated the role of tumor cell-hepatocyte interaction in liver metastasis using liver metastatic subline H-59 of the Lewis lung carcinoma. A monoclonal antibody (MAb) C-11 was produced which was highly specific to liver metastatic H-59 cells. Our in vitro studies showed that this MAb and its F

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24

Zhang, Xiaoyan. "The effect of long-term exposure to transforming growth factor-b1 on the spontaneous transformation of cultured rat liver epithelial cells /." Thesis, McGill University, 1992. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=56969.

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In contrast to normal cells, most neoplastic cells are resistant to the growth inhibitory effect of the transforming growth factor-$ beta$(TGF-$ beta$). The neoplastic transformation of cultured rat liver epithelial cells induced spontaneously or by chemical carcinogens and oncogenes is consistently associated with the development of resistance to the mito-inhibitory effect of TGF-$ beta$, suggesting that such phenotype plays an essential role during the transformation of these cells. We have studied the development of this "TGF-$ beta$, resistant" phenotype in a clonal strain of early passage

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25

Morey, Scott D. "Novel approaches to diagnosis and prevention of bovine fatty liver." Thesis, Kansas State University, 2010. http://hdl.handle.net/2097/4640.

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Master of Science<br>Department of Animal Sciences and Industry<br>Barry J. Bradford<br>The prevalence of fatty liver in transition dairy cattle has been reported to be as high as 50%. There are a few reliable on-farm diagnostic tools and even fewer methods to effectively prevent fatty liver. Non-alcoholic steatohepatitis, an advanced form of non-alcoholic fatty liver in humans, is accurately diagnosed with a commercial blood test that detects plasma cytokeratin-18 (CK18) fragments released during hepatocyte apoptosis. A study was performed using 89 Holstein cows in early lactation to determin

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26

Pretorius, Jakobus. "Investigation of the relationship between genetic and environmental risk factors associated with obesity and insulin resistance in South African patients with non-alcoholic fatty liver disease(NAFLD)." Thesis, Stellenbosch : Stellenbosch University, 2012. http://hdl.handle.net/10019.1/71689.

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Thesis (MSCMedSc)--Stellenbosch University, 2012.<br>Includes bibliography<br>ENGLISH ABSTRACT: Non-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease in the world. The disease spectrum of NAFLD extends from steatosis (types 1,2) to non-alcoholic steatohepatitis (NASH) with inflammation (types 3,4). The aims of the study were 1) to analytically validate high-throughput real time polymerase chain reaction (RT-PCR) assays for three selected single nucleotide polymorphisms (SNPs), FTO rs9939609 (intron 1 T>A), TNF-α rs1800629 (-308 G>A) and PPARγ rs1801282 (Pro12Ala

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27

Hollie, Norris I. II. "Role of Group 1B Phospholipase A2 in Diet-induced Hyperlipidemia and Selected Disorders of Lipid Metabolism." University of Cincinnati / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1378112803.

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28

Mahdi, A. K. "Molecular pathology : the roles of P53 in the oxidative stress and DNA damage responses in chronic liver disease and hepatocellular carcinoma." Thesis, University of Newcastle upon Tyne, 2018. http://hdl.handle.net/10443/4147.

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Non-alcoholic fatty liver disease (NAFLD) has become the commonest form of chronic liver disease in western nations and is rapidly rising in the Asia-Pacific. As yet treatments are limited to diet modification and life style change, which is rarely effective. NAFLD is associated with an increasing risk of developing hepatocellular carcinoma (HCC), which is also increasing markedly and is a significant cause of death. The disease progression is difficult to study in humans as invasive procedures are needed. We have developed a mouse model reflecting the human condition to investigate mechanisms

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29

Flores, Mariana Martins. "TUMORES HEPÁTICOS MALIGNOS PRIMÁRIOS DE CÃES DA REGIÃO CENTRAL DO RIO GRANDE DO SUL (1965-2012)." Universidade Federal de Santa Maria, 2013. http://repositorio.ufsm.br/handle/1/10138.

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Conselho Nacional de Desenvolvimento Científico e Tecnológico<br>Primary hepatic malignant tumors (PHMT) represent an important cause of death of dogs at the Laboratório de Patologia Veterinária of the Universidade Federal de Santa Maria (LPV-UFSM). Based in this information, the prevalence and epidemiological and immunohistochemical aspects of PHMT were reviewed in dogs necropsied in a 48-year period (1965-2012). Out of those7,373 dogs, 64 died due to PHMT, which corresponds to 0.9% of the dogs dying from any cause in the period; 7.8% of dogs which deaths were caused by tumors in general; and

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30

Lake, April D. "Hepatic stress response mechanisms in progressive human nonalcoholic fatty liver disease." Thesis, The University of Arizona, 2013. http://pqdtopen.proquest.com/#viewpdf?dispub=3590010.

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<p> Nonalcoholic fatty liver disease (NAFLD) has become a worldwide, chronic liver disease of increasing clinical significance. It is closely associated with the rising epidemics of obesity and insulin resistance. Up to 17% of the United States population may progress from the disease stage characterized as simple, benign steatosis to the more severe, inflammatory stage of nonalcoholic steatohepatitis (NASH). This progression occurs through 2<sup>nd</sup> 'hits' of increased oxidative stress and inflammation to a liver that has been sensitized by lipotoxic stress. NASH is also characterized by

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31

Jemail, Leila. "Pivotal roles of Kupffer cells in the progression and regression of DDC-induced chronic choangiopathy." Kyoto University, 2019. http://hdl.handle.net/2433/242350.

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32

Felício, Paula Raquel Gaspar. "Métodos de diagnóstico de doença hepática em equinos." Master's thesis, Universidade de Lisboa, Faculdade de Medicina Veterinária, 2018. http://hdl.handle.net/10400.5/15945.

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Dissertação de Mestrado Integrado em Medicina Veterinária<br>Esta dissertação de mestrado tem como objetivo apontar os métodos de diagnóstico de patologia hepática em equinos, úteis na prática clínica. Os sinais clínicos também são considerados como auxiliares de diagnóstico, no entanto só estão presentes quando cerca de 80% do parênquima hepático está afetado, pelo que se torna importante realizar exames complementares de diagnóstico. A realização de exames laboratoriais para diagnóstico e prognóstico de doença hepática são muito importantes e constituem a primeira abordagem médica na suspe

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33

Dixon, Laura J. "The role of caspase-1 in liver and adipose tissue during metabolic dysregulation in mouse models on NASH." Case Western Reserve University School of Graduate Studies / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=case1355861009.

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34

Oliveira, Cacilda Pedrosa de. ""Alterações hepáticas em grandes obesos: avaliações clínico-laboratoriais e histopatológicas antes do tratamento cirúrgico da obesidade"." Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/5/5144/tde-31052006-150549/.

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A doença hepática gordurosa não-alcoólica (DHGNA) e a esteatohepatite (EHNA) são freqüentes nos obesos. O objetivo foi determinar a prevalência de DHGNA/EHNA e Síndrome Metabólica (SM) nos grandes obesos; definir preditores de EHNA; estabelecer critérios histológicos para o diagnóstico da EHNA. Avaliados 325 pacientes encaminhados à cirurgia bariátrica (IMC = 35 kg/m2), dos quais 146 foram submetidos à análise histológica; as variáveis clínicas e bioquímicas analisadas e correlacionadas com a histologia. A DHGNA ocorreu em 111 (76%) pacientes e a prevalência de EHNA, conforme critério histológ

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35

Fonseca, Gilton Marques. "A importância prognóstica dos grupamentos pouco diferenciados e brotamentos tumorais nas metástases hepáticas do câncer colorretal." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/5/5168/tde-05122018-121641/.

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INTRODUÇÃO: A ressecção hepática é o único tratamento potencialmente curativo para as metástases hepáticas de câncer colorretal (MHCCR), porém com taxas de recidiva entre 60 e 70%. Desta forma, faz-se necessário um melhor entendimento das vias de disseminação e recidiva da doença. Os brotamentos tumorais (BT) e grupamentos pouco diferenciados (GPD), relacionados à transição epitélio-mesenquimal, são fatores prognósticos para o câncer colorretal; entretanto sua presença e importância nas MHCCR ainda não estão estabelecidas. Os objetivos deste trabalho foram avaliar a presença dos BT e GPD nas M

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Júnior, Carlos Kiyoshi Furuya. "Efeitos da cirurgia de Fobi-Capella na doença hepática gordurosa não alcoólica (DHGNA): estudo prospectivo de dois anos." Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/5/5147/tde-31102006-142922/.

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Introdução: A incidência de obesidade é crescente e alarmante, principalmente no mundo ocidental. De acordo com o National Center for Health Statistics, cerca de 61% da população adulta nos Estados Unidos está acima do peso e 30% é obesa, sendo que 5 a 6% está classificada na faixa de obesidade Grau III. No Brasil, o Ministério da Saúde aponta que 32,9% dos brasileiros estão fora da faixa de peso ideal, e 4,8% dos homens e 11,7% das mulheres encaixam-se na faixa de obesidade Grau III. Devido a alta prevalência da Doença Hepática Gordurosa Não Alcoólica (DHGNA) em pacientes portadores de obesid

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Barcelos, Aléverson da Silva. "Avaliação macroscópica, histopatológica e bacteriológica de fígados de frangos (Gallus gallus) condenados no abate pela inspeção sanitária." Universidade Federal de Santa Maria, 2005. http://repositorio.ufsm.br/handle/1/10241.

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Gross, microscopic, and bacteriologic evaluation of broiler livers condemned by the Federal Inspection Service of Animal Products was performed. One hundred broiler livers were sampled at slaughter. Ninety of them had gross changes and 10 of them were grossly normal. The sampling was done in two slaughter houses located in the State of Rio Grande do Sul, Brazil. One of these two places slaughters 120,000 broilers/day, and the other one slaughters over 300,000 broilers/day. For the gross evaluation, the considered parameters were shape, color, size, texture, odor, and the presence of other visi

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38

Sukhdeo, Kumar. "Defining immunophenotypic signatures of stem cells." Case Western Reserve University School of Graduate Studies / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=case1373038255.

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Sacks, Jessica Erin. "Targeting Mitochondrial Pathways in Obesity and Type 2 Diabetes." Case Western Reserve University School of Graduate Studies / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=case1522935947635474.

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40

Milot, Laurent. "Imagerie des métastases hépatiques colorectales à l’ère des résections chirurgicales complexes : peut-on en améliorer la spécificité ?" Electronic Thesis or Diss., Lyon, 2019. http://www.theses.fr/2019LYSE1040.

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Les métastases hépatiques du cancer colorectal (MHCR) sont fréquentes et sont associées à une mortalité significative. Ces dernières décennies, des progrès thérapeutiques importants ont permis d'en améliorer le pronostic. Plus particulièrement, le rôle des résections hépatiques s'est considérablement élargi dans la maladie métastatique limitée au foie, conduisant à un changement radical dans la prise en charge. Ceci a naturellement eu des répercussions sur l'imagerie, qui doit être très performante au niveau lésionnel, nécessitant des sensibilité et spécificité très élevées. Si les techniques

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Milot, Laurent. "Imagerie des métastases hépatiques colorectales à l’ère des résections chirurgicales complexes : peut-on en améliorer la spécificité ?" Thesis, Lyon, 2019. http://www.theses.fr/2019LYSE1040.

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Les métastases hépatiques du cancer colorectal (MHCR) sont fréquentes et sont associées à une mortalité significative. Ces dernières décennies, des progrès thérapeutiques importants ont permis d'en améliorer le pronostic. Plus particulièrement, le rôle des résections hépatiques s'est considérablement élargi dans la maladie métastatique limitée au foie, conduisant à un changement radical dans la prise en charge. Ceci a naturellement eu des répercussions sur l'imagerie, qui doit être très performante au niveau lésionnel, nécessitant des sensibilité et spécificité très élevées. Si les techniques

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42

Юган, Я. Л., та Я. А. Соцька. "Вплив вірусу Епштейна–Барр на розвиток та прогресування неалкогольного стеатогепатиту". Thesis, Сумський державний університет, 2014. http://essuir.sumdu.edu.ua/handle/123456789/37986.

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Згідно з даними ВООЗ, захворювання, що зумовлені герпесвірусами, будуть визначати як інфекційну, так і соматичну патологію XXI ст. Величезний інтерес і увагу вчених привертає вірус Епштейна–Барр (ВЕБ). ВЕБ обумовлює всі випадки серопозитивного клінічно маніфестного інфекційного мононуклеозу (ІМ) і більшість серонегативного. В якості несприятного фону для розвитку ІМ у жителів промислових регіонів Донбасу нерідко виявляється хронічна патологія печінки, найчастіше, у вигляді неалкогольний стеатогепатит (НАСГ). За останній час суттєва увага дослідників приділяється метаболічним процесам, які регу

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43

Degli, Esposti Davide. "Les mécanismes de réponse à l'inflammation chronique dans le foie stéatosique et les conséquences sur l'homéostasie cellulaire et la cancérogénèse." Phd thesis, Université Paris Sud - Paris XI, 2011. http://tel.archives-ouvertes.fr/tel-00652594.

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Le foie est un organe essentiel à la vie chez tous les mammifères. C'est un organe central du métabolisme énergétique et de la détoxification des substances xénobiotiques auxquelles l'individu est exposé. Le foie est la cible d'agressions diverses, telles que les virus, l'alcool, les substances chimiques présentes dans l'alimentation ou l'environnement. Il peut également subir destransformations pathologiques profondes, lors du diabète ou de l'obésité par exemple.La stéatose hépatique, caractérisée par une accumulation de triglycérides sous forme de vésiculesgénérant une réponse inflammatoire,

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El, Kebir-Yazid Fatima Zohra. "Etude qualitative et quantitative de l'hépatocancerogénèse primaire expérimentale chez le rat carencé ou non en protéines." Paris 13, 1987. http://www.theses.fr/1987PA132018.

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Campos, Priscila Brizolla de. "Caracterização clínica e histológica do carcinoma hepatocelular (CHC) secundário à doença hepática gordurosa não alcoólica (DGHNA)." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/5/5168/tde-16022018-091511/.

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O aumento na incidência do carcinoma hepatocelular (CHC) tem sido atribuído ao aumento da obesidade, diabetes e doença hepática gordurosa não alcoólica. (DHGNA), estando ainda por ser melhor esclarecidos vários aspectos histopatológicos e imuno-histoquímicos. O objetivo deste estudo é avaliar aspectos clínicos e patológicos de pacientes com CHC secundário a DHGNA, assim como relacionar a marcadores imuno-histoquímicos de classe proliferativa. Avaliamos 35 espécimes de CHC de 21 pacientes diagnosticados com DHGNA submetidos a ressecção hepática (12 pacientes) ou a transplante hepático (8 pacien

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Fitzgerald, Anthony. "Extraction of tissue electrical characteristics from pixels of MFEIT images." Thesis, Queensland University of Technology, 1997.

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Zahid, Muhammad Nauman. "Impact of SR-BI and CD81 on Hepatitis C virus entry and evasion." Phd thesis, Université de Strasbourg, 2012. http://tel.archives-ouvertes.fr/tel-00818590.

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Hepatitis C virus (HCV) is a major cause of liver cirrhosis and hepatocellular carcinoma. In the first part of my PhD, we aimed to further characterize the role of scavenger receptor class B type I (SR-BI) in HCV infection. While the SR-BI determinants involved in HCV binding have been partially characterized, the post-binding function of SR-BI remains remained largely unknown. To further explore the role of HCV-SR-BI interaction during HCV infection, we generated a novel class of anti-SR-BI monoclonal antibodies inhibiting HCV infection. We demonstrated that human SR-BI plays a dual role in t

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Delabrousse, Éric. "Thermoablation ultrasonore hépatique appliquée par voie interstitielle percutanée sous guidage échographique et sous contrôle actif de température en IRM." Phd thesis, Université Claude Bernard - Lyon I, 2009. http://tel.archives-ouvertes.fr/tel-00692361.

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Un applicateur ultrasonore interstitiel IRM compatible a été développé pour le traitement percutané du CHC sous contrôle de l'imagerie. Deux grands axes expérimentaux ont été abordés : 1) au cours d'une première expérimentation réalisée in vivo sur le foie de porc, des macro lésions correspondant à la fusion de lésions élémentaires par rotation du transducteur sur 360° ont pu être réalisées par voie percutanée sous contrôle échographique. Les macro lésions obtenues possédaient une taille voisine de celles obtenues en pratique clinique par la RF. De plus, les lésions élémentaires se montraient

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Delabrousse, Éric. "Thermoablation ultrasonore hépatique appliquée par voie interstitielle percutanée sous guidage échographique et sous contrôle actif de température en IRM." Electronic Thesis or Diss., Lyon 1, 2009. http://www.theses.fr/2009LYO10104.

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Un applicateur ultrasonore interstitiel IRM compatible a été développé pour le traitement percutané du CHC sous contrôle de l'imagerie. Deux grands axes expérimentaux ont été abordés : 1) au cours d'une première expérimentation réalisée in vivo sur le foie de porc, des macro lésions correspondant à la fusion de lésions élémentaires par rotation du transducteur sur 360° ont pu être réalisées par voie percutanée sous contrôle échographique. Les macro lésions obtenues possédaient une taille voisine de celles obtenues en pratique clinique par la RF. De plus, les lésions élémentaires se montraient

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Le, Moine Olivier. "Interleukin-10 in liver ischaemia-reperfusion injury and alcoholic cirrhosis." Doctoral thesis, Universite Libre de Bruxelles, 1996. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/212296.

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