Relevant bibliographies by topics / Liver Rats as laboratory animals

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Academic literature on the topic 'Liver Rats as laboratory animals'

Author: Grafiati
Published: 4 June 2021
Last updated: 1 February 2022

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Journal articles on the topic "Liver Rats as laboratory animals"

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Rufino, Marcos Natal, Marney Pascoli Cereda, Wanessa Teixeira Gomes Barreto, Alanderson Rodrigues da Silva, Gisele Braziliano de Andrade, and Heitor Miraglia Herrera. "Pathological effects of acetone cyanohydrin in swiss rats." Ciência e Agrotecnologia 40, no. 5 (October 2016): 577–84. http://dx.doi.org/10.1590/1413-70542016405049015.

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ABSTRACT Cassava has been widely used for animal and human nutrition. It has also been demonstrated to have antineoplastic and anthelmintic properties. Toxicity due to cassava consumption has been reported in ruminants and laboratory animals; therefore, this study aimed to investigate the toxic effects of acetone cyanohydrin, a metabolite of linamarin that is present in cassava, in Wistar rats. Six groups of five animals each were used to evaluate the toxic effects of acetone cyanohydrin administered at 25 (G1), 50 (G2), 75 (G3), 100 (G4) and 125 (G5) µmol/kg as a single oral dose. The control group received acidified water (pH 3.5). The animals were monitored after administration of acetone cyanohydrin, and clinical symptoms were recorded. Serum enzyme levels were measured to assess the kidney and liver function. During necropsy, tissue samples were collected for histopathological examination. After administration, some animals in the G2, G4, and G5 groups presented neurological symptoms such as convulsions, involuntary muscle contraction, staggering gait, motor coordination disability, prostration, and mydriasis. All of the animals in the G5 and four animals in the G4 group died seven minutes after the administration of acetone cyanohydrin. Animals in the other groups, particularly in G2, recovered from the acute phase. Biochemical analysis revealed hepatic lesions and liver dysfunction. Histopathology revealed severe lesions in both the liver and brain. In conclusion, acetone cyanohydrin has toxic effects in the liver, lung, and central nervous system in rats; however, at concentrations up to 25 µmol/kg, the animals could survive the acute phase.
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Luo, Q. J., and J. C. MacRae. "Nutritional and hormonal regulation of hepatic IGF-1 production in sheep and rats." Proceedings of the British Society of Animal Production (1972) 1993 (March 1993): 192. http://dx.doi.org/10.1017/s0308229600025149.

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Circulating concentrations of insulin-like growth factor-1 (IGF-1) are closely related to the nutrition of animals and their rates of growth. The major site of IGF-1 production is thought to be the liver. Whilst growth hormone (GH) is thought to be the main regulator of IGF-1 production in farm animals, in laboratory rats, altering the GH status of the animal (without hyperphysectomy) has little influence on circulating IGF-1 levels. A series of studies have been conducted with primary cultured rat and sheep hepatocytes to investigate the influence of GH and nutrient availability on the production of IGF-1 by liver cells.
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Usmanova, Elza N., Anna S. Fazlyeva, Denis O. Karimov, Munira M. Ziatdinova, Rustem A. Daukaev, Nadezhda Yu Khusnutdinova, and Mihail V. Kurilov. "Toxicokinetics of aluminum in rats." Hygiene and sanitation 99, no. 9 (October 20, 2020): 1007–10. http://dx.doi.org/10.47470/0016-9900-2020-99-9-1007-1010.

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Introduction. Aluminum is one of the most common elements in nature that is potentially toxic to humans. Aluminum compounds are widely used in the aviation and food industries, metallurgy, electrical engineering, and medicine. Aluminum is capable of accumulating in the human body, which creates a risk for the development of severe diseases. Material and methods. Acute intoxication of aluminum hydroxide was simulated on white outbred rats weighing 170-220 g, divided into 8 groups (intact and 7 experimental). By the atomic absorption method, the concentrations of aluminum, calcium, magnesium, and iron in the organs of laboratory animals (kidneys, liver, blood, and brain) were determined 1, 2, 4, 6, 24, 48, and 96 hours after intoxication. Results. The accumulation of aluminum was observed to a greater extent in the liver, kidneys, blood, to a lesser extent in the brain. Aluminum affects the homeostasis of essential elements, for example, in the experiment, a decrease in the content of calcium and magnesium in the organs of laboratory animals is observed. The seed level does not have a strong effect on the level of iron. At the end of the experiment, the concentration of aluminum in the liver, blood, and brain of rats remains higher than in the control group. Conclusion. Aluminum is capable of accumulating in vital organs and affecting the homeostasis of the essential elements of the body. The circulation of aluminum in the biological media of a living organism, like many processes, is undulating, and it can accumulate and diffuse for a long time in various organs of experimental animals.
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Farcich, E. A., and E. H. Morgan. "Diminished iron acquisition by cells and tissues of Belgrade laboratory rats." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 262, no. 2 (February 1, 1992): R220—R224. http://dx.doi.org/10.1152/ajpregu.1992.262.2.r220.

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Iron uptake from transferrin by a variety of cells and tissues of homozygous Belgrade laboratory rats was compared with heterozygotes, and normal and iron-deficient Wistar rats. In all cases the results for homozygous Belgrade rats were lower than for the other animals. The maximal rate of iron uptake by fibroblasts cultured in vitro and iron passage to homozygous fetuses in utero was less than 60% of control values. In vivo studies of 15-day-old Belgrade rats revealed a defect in the homozygotes with reduced iron transfer to heart, liver, brain, and femurs. In addition, adult Belgrade laboratory rats had impaired intestinal iron absorption compared with the genetically normal animals. It is concluded that the defect in iron metabolism in the Belgrade laboratory rat is a ubiquitous one that affects transport of iron across membranes of many types of cells, resulting in low intracellular iron levels. This suggests that the genetic defect leads to a widely expressed abnormality in the structure and/or function of a membrane carrier for iron.
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Meyer, Tufi Neder, and Alcino Lázaro da Silva. "A SIMPLE EXPERIMENTAL MODEL OF HEAT SHOCK RESPONSE IN RATS." Acta Cirurgica Brasileira 13, no. 4 (October 1998): 217–21. http://dx.doi.org/10.1590/s0102-86501998000400003.

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Objective: To obtain a simple model for the elicitation of the heat shock response in rats. Design: Laboratory study. Setting: University research laboratories. Sample: Seventy-nine adult male albino rats (weight range 200 g to 570 g). Procedures: Exposure to heat stress by heating animals in a warm bath for 5 min after their rectal temperatures reached 107.60 F (420 C). Liver and lung samples were collected for heat-shock protein 70 (HSP70) detection (Western analysis). Results: Western analysis was positive for HSP70 in the liver and in the lungs of heated animals. There was a temporal correlation between heating and HSP70 detection: it was strongest 1 day after heating and reduced afterwards. No heated animals died. Conclusion: These data show that heating rats in a warm (45o C) bath, according to parameters set in this model, elicits efficiently the heat shock response.
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Klement'eva, O., O. Vlasova, D. Stepchenkov, K. Luneva, K. Ternovskaya, V. Petriev, E. Stepchenkova, et al. "Results of Preclinical Safety Tests of Radiopharmaceutical with 90Y for Intra-arterial Radioembolization of Liver Cancer." Medical Radiology and radiation safety 65, no. 5 (April 25, 2021): 51–59. http://dx.doi.org/10.12737/1024-6177-2020-65-5-51-59.

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Purpose: Performing a safety study of a radiopharmaceutical drug with yttrium-90 for intra-arterial radioembolization of inoperable patients with primary and metastatic liver cancer. Material and methods: The developed radiopharmaceutical is a microspheres of human blood albumin with a diameter of 25-40 microns, modified with diethylenetriaminpentaacetic acid and labeled with 90Y radionuclide. The safety of the radiopharmaceutical was studied by the following indicators: acute toxicity of lyophilized reagents, subchronic toxicity of the radiopharmaceutical on two types of animals, local irritant effect of the radiopharmaceutical therapeutic activity in equivalent terms on laboratory animals, specific toxicity (allergizing effect) of lyophilized reagents for the preparation of a radiopharmaceutical drug. Female and male BALB/C mice, Wistar rats, chinchilla rabbits, and albino Guinea pigs were taken as experimental animals. All animals were obtained from certified laboratory animal nurseries. Results: During acute toxicity studies, the maximum safe dose of an inactive drug was determined. In terms of per person, it exceeds the intended dose for clinical use by almost 20 times. The study of the subchronic toxicity of the radiopharmaceutical did not reveal any symptoms of intoxication. The survival rate of the animals during the entire observation period was absolute. Standard behavior and appearance were observed in animals. The dynamics of body weight was positive, and the body temperature of rats and rabbits did not exceed the limits allowed. Samples of the finished dosage form of the drug did not have a local irritant effect. The solution of inactive components of lyophilized reagents for the preparation of a radiopharmaceutical drug did not have an allergenic effect in quantities ten times higher than the doses administered to a person. Conclusion: According to the results of preclinical studies, the radiopharmaceutical should be considered safe for use. The results of preclinical studies allow us to recommend the drug for clinical research.
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Kuzminova, Elena, Marina Semenenko, Evgeny Dolgov, Serik Kanatbaev, and Andrey Abramov. "Pharmacological protection of the detoxification activity of animals’ liver with the help of phospholipid and polysaccharide nature substances complex." E3S Web of Conferences 175 (2020): 03002. http://dx.doi.org/10.1051/e3sconf/202017503002.

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Currently, among chemical pollutants a significant danger to the health of animals and humans represent oxygen-containing nitrogen compounds nitrates and nitrites, which are widely used as mineral fertilizers. The article presents data on the study of chronic nitrate intoxication, reproduced in laboratory animals and its pharmacological correction with a complex of substances of phospholipid and polysaccharide nature. The introduction of sodium nitrate to non-linear rats for 30 days at a dose of 3.8 mg per animal leads to the development of intoxication in rats with dominant signs of liver damage. On this background, the use of the complex of beet fiber and rapeseed lecithin leads to a weakening of nitrate toxicosis, which is demonstrated by an increase in rats’ body weight, weakening of the clinical manifestations of intoxication, a decrease in cytolytic syndrome, intrahepatic cholestasis and impaired protein synthesis function of liver.
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Harashchuk, M. I., L. M. Stepchenko, T. L. Spitsina, and V. R. Goryaniy. "Metabolism state in laboratory rats when using amaranth oil and Humilid." Theoretical and Applied Veterinary Medicine 9, no. 1 (2021): 30–34. http://dx.doi.org/10.32819/2021.91005.

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The search for new natural non-toxic biologically active substances for animals used to correct and stimulate metabolic processes, and through it the ability to control the growth and animals’ productivity, the state of their natural resistance is the main task of the present. The paper presents study results on the effect of cold-pressed amaranth oil and biologically active additive of humic nature «Humilid» when used simultaneously on the general body condition, growth indicators of laboratory rats, morphofunctional and biochemical parameters of their blood. To achieve this goal, the following tasks were set: – to investigate how cold-pressed amaranth oil affects the metabolic processes in the body of laboratory rats; – to conduct research and analyze the effect of the cold-pressed amaranth oil and a humic nature biologically active substance «Humilid» simultaneous use on the indicators of their homeostasis. To accomplish the tasks, the following research methods were used: physiological, morpho-functional, and blood biochemical analysis in experimental laboratory rats. Sexually mature male white rats of 2 months age were used in the experiment. For the study, three groups of animals were formed. The experiment lasted four weeks, during which the animals of the first experimental group received daily, in addition to the main feed settled amaranth oil in the amount of 0.1 ml per rat, and free access to the drinking water. Rats of the second experimental group in addition to the main feed received settled amaranth oil in the amount of 0.1 ml, and free access to the drinking of 0.005% solution Humilid. It was found that the simultaneous use of cold-pressed amaranth oil and Humilid in laboratory rats had a positive effect on the state of erythron, erythrocytes count increased by an average of 28% (P < 0.001), hemoglobin concentration by 10% (P < 0.05). At the same time in animals the biosynthetic function of the liver improved, the total protein content in the blood significantly increased by 10% (P < 0.05), and the amount of albumin by 25% (P < 0.01). Energy processes in the body of experimental animals were increased, that pointed a decrease in blood glucose levels by 22% (P < 0.05). The obtained data obtained indicates that the simultaneous use of amaranth oil and Humilid had a positive effect on the state of homeostasis and metabolic processes in the body of laboratory rats. Thus for them synergistic action is noted.
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Varkholiak, I. S., and B. V. Gutyj. "Determination of acute toxicity of “Bendamin” drug in laboratory animals." Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies 20, no. 92 (December 10, 2018): 209–12. http://dx.doi.org/10.32718/nvlvet9243.

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The study of acute toxicity is a mandatory stage in the investigation of new drugs, which allows assessing the health of substances for health in the short-term and determining the class of toxicity and breadth of therapeutic action. Therefore, at the first stage of the study, the acute toxicity of Bendamin Cardiomatography was studied, in particular the determination of maximum tolerant, toxic and intermittent lethal doses for laboratory animals. The acute toxicity of Bendamin was determined in two stages: indicative and expanded experiments. In the indicative trial, the drug was administered intragastrically at doses of 50, 500 and 5000 mg/kg body weight. Three white mice and rats were used for each dose. In an expanded experiment, Bendamin was administered intragastrically at doses of 5000 and 10000 mg/kg body weight. In determining the acute toxicity of Bendamin, the DL50 value could not be determined, indicating a low toxicity of the test substance. Thus, the DL50 drug for intragastric administration to white mice is greater than 5000 mg/kg m. The general condition of animals in the studied groups did not differ from the state of intact animals: coordination of movements and skeletal muscle tone, pain response, tactile and acoustic stimuli were adequate, the frequency of breathing and the rhythm of heart rate were within the normal range. At administration of the preparation in a dose of 5000 mg/kg m. T, an insignificant inhibition was established, which is related to the introduction of a large amount of the drug. In determining the coefficients of the mass of the internal organs of laboratory animals, a slight decrease in the weight coefficient of the liver was found in both mice and in rats. The “Bendamin” drug when administered to white mice and rats in the stomach in the maximum amount does not cause symptoms of poisoning and behavioral abnormalities. According to GOST 12.1.007-76, Bendamin, for intragastric administration, according to the degree of hazard belongs to grade 4 toxicity – low toxicity substances (DL50 more than 10000 mg/kg body weight). In the future, it is planned to investigate the chronic toxicity and cumulative properties of the drug in laboratory animals.
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Southon, Susan, G. Livesey, Jennifer M. Gee, and I. T. Johnson. "Differences in intestinal protein synthesis and cellular proliferation in well-nourished rats consuming conventional laboratory diets." British Journal of Nutrition 53, no. 1 (January 1985): 87–95. http://dx.doi.org/10.1079/bjn19850013.

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1. Male Wistar rats (100 g) were given a commercial pellet feed or a semi-synthetic diet ad lib. Although the pellet-fed group grew slightly faster than the other group during the early part of the feeding period, there was no significant difference between the final weights of the groups.2. The fractional rates of protein synthesis in jejunum, proximal ileum and liver were measured by a technique based on the determination of L-[4−3H]phenylalanine incorporation over a short time period. Protein synthesis was higher in both jejunum and ileum of the pellet-fed rats compared with those eating the semi-synthetic diet, but there was no difference between the rates of protein synthesis measured in the livers of the groups.3. The rate of mucosal cell division was significantly faster in the ileal mucosa of the pellet-fed group compared with the other group, and there were significant differences in some aspects of mucosal morphology.4. The maintenance of higher rates of cell turnover and protein synthesis in animals given commercial pellet feed is unexplained, but it may be related to the presence of non-absorbable polysaccharides or other complex plant materials in the pellet feed.
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Dissertations / Theses on the topic "Liver Rats as laboratory animals"

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Ho, Chi-tat, and 何志達. "A study of the effects of (-)-epigallocatechin-3-gallate (EGCG) on a clinically relevant rat model of non-alcoholic fatty liver diseases(NAFLD)." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B45153036.

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Ye, Xingshen. "Studies on effects of coptis extract and berberine against carbon tetrachloride-induced liver damage in rats." View the Table of Contents & Abstract, 2007. http://sunzi.lib.hku.hk/hkuto/record/B38718832.

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Ye, Xingshen, and 叶星沈. "Studies on effects of coptis extract and berberine against carbon tetrachloride-induced liver damage in rats." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B38755208.

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Goboza, Mediline. "The biochemical effects of Hypoxis hemerocallidea in the kidney and liver of streptozotocin-induced diabetic male Wistar rats." Thesis, Cape Peninisula University of Technology, 2015. http://hdl.handle.net/20.500.11838/2233.

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Thesis (MTech (Biomedical Technology))--Cape Peninsula University of Technology, 2015.
Diabetes mellitus (DM) is an endocrine disorder that is characterised not only by severe hyperglycemia but also altered metabolism of glucose and lipids. It is a major health problem worldwide and its impact is greatly noticed in developing countries due to the lack of adequate medical facilities. Oxidative stress remains the principal factor that actively plays major roles in the onset and progression of diabetes mellitus and its complications. The use of medicinal plants in the treatment of DM has undisputedly gained the attention and interest of researchers throughout the globe mainly because plants have established promising outcomes in the treatment of diabetes. It is evident that the plants’ constituents possess therapeutically potent metabolites that have beneficial effects such as antioxidant, antidiabetic, anticancer, anti-inflammatory and antibacterial activities. Hypoxis hemerocallidea is a native plant that grows in the Southern African regions. H. hemerocallidea is well known for its beneficial medicinal values. In South Africa it is known as the African potato. The main aim of this study was to investigate both the beneficial and also the possible toxic effects of H. hemerocallidea in the kidney and liver tissues of streptozotocin-induced diabetic male Wistar rats by assessing the antioxidant status and selected biochemical parameters in the two studied organs. Diabetes was induced in overnight fasted rats by administration of a single intraperitoneal injection of STZ at a dosage of 50mg/kg in citrate buffer (0.1 M at 4.5 pH). Hyperglycemia was confirmed 72 hours after induction of diabetes using STZ in rats with glucose levels > 15 mmol/l. Treatment with the plants extract commenced on the fourth day after STZ administration via gastric gavage that was done once a day over a 6 week period. The effects of H. hemerocallidea on glucose, body weight, liver and kidney weights, liver function, kidney function and the oxidative status were evaluated after the feeding period.
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Bayram, Dilek Öncü Meral. "Sıçan karaciğeri üzerine tiyopental sodyum, propofol, etomidate ve midazolam isimli anestezik maddelerin etkisinin ışık mikroskobik düzeyde incelenmesi /." Isparta : SDÜ Sağlık Bilimleri Enstitüsü, 2005. http://tez.sdu.edu.tr/Tezler/TT00203.pdf.

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Euler, Henrik von. "Electrochemical treatment of tumours /." Uppsala : Dept. of Small Animal Clinical Sciences, Swedish Univ. of Agricultural Sciences ([Institutionen för kirurgi och medicin - smådjur], Sveriges lantbruksuniv.), 2002. http://epsilon.slu.se/v133.pdf.

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Van, der Merwe J. Debora. "Exposure to polyphenol-enriched rooibos (Aspalathus linearis) and honeybush (Cyclopia spp.) extracts : implications of metabolism for the oxidative status in rat liver." Thesis, Stellenbosch : Stellenbosch University, 2012. http://hdl.handle.net/10019.1/71804.

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Thesis (PhD(FoodSc))--Stellenbosch University, 2012.
ENGLISH ABSTRACT: Potential beneficial and/or adverse modulatory effects of polyphenol-enriched extracts of rooibos (Aspalathus linearis) and honeybush (Cyclopia spp.) on the antioxidant homeostasis in the liver were investigated. Phase II metabolism of aspalathin and mangiferin, the major polyphenols of rooibos and honeybush respectively, was assessed for potential glucuronidation and sulphation. Glucuronidation resulted in a loss of antioxidant activity for aspalathin and mangiferin in post-column HPLC-DAD-DPPH• and HPLC-DAD-ABTS•+ assays and also a decreased activity of iron chelating properties of mangiferin in the FRAP assay. Two independent studies for 28 and 90 days with polyphenol-enriched extracts (PEEs) of unfermented rooibos [Aspalathus linearis (PER)] and honeybush [Cyclopia. subternata (PECsub) and C. genistoides (PECgen)] in male Fischer rats were conducted to assess possible beneficial and/or adverse biological effects. PECgen was only included in the 28 day study. PEEs were characterised by in vitro antioxidant assays and HPLC analysis. The importance of detailed chemical characterization of rooibos and honeybush when investigating biological effects in vivo is clear as distinctive biological effects and major differences in compositions were evident. Biological parameters included were serum chemical parameters, activities of selected antioxidant enzymes, levels of glutathione and the modulation of expression of oxidative stress and antioxidant defense related genes in the liver. Sub-chronic (90 days) exposure of rats to PER and PECsub both adversely affected iron absorption significantly (P<0.05) and significantly (P<0.05) and markedly lowered levels of reduced glutathione (GSH) in the liver. The high levels of polyphenol intake were implicated and interaction with glutathione was postulated to occur via catechol o-quinone conjugations with GSH. This was also implicated in the significantly (P<0.05) increased activity of glutathione reductase (GR) following 28 days. These findings suggest that PEEs from rooibos and honeybush have the potential to alter the glutathione homeostasis, which could contribute to oxidative status in the liver. PECsub resulted in alterations in the liver biliary system which was manifested as significantly (P<0.05) increased serum total bilirubin (Tbili) and alkaline phosphatase (ALP), depending on the age of the rats, level of total polyphenols and duration of exposure. The expression of a number of oxidative stress and antioxidant defense related genes were differentially altered by the PEEs of rooibos and honeybush in rat liver and further indicated potential oxidative stress. Modulatory effects of PEEs on expression of 84 of these genes in rat liver were assessed with a quantitative real-time reverse transcription polymerase chain reaction (RT-PCR) array and provided additional insights into the possible adverse and protective effects of rooibos and honeybush. Further investigation on total polyphenol dose levels and time of exposure in the application of PEEs of rooibos and honeybush as dietary supplements and functional foods is recommended and will also be of value in anticipated regulatory requirements for future substantiation of safety and efficacy.
AFRIKAANSE OPSOMMING: Die moontlike voordelige en/of nadelige modulerende effekte van polifenol-verrykde ekstrakte van rooibos (Aspalathus linearis) en heuningbos (Cyclopia spp.) op die antioksidant homeostasis in die lewer is ondersoek. Die fase II metaboliete van aspalatien en mangiferin, die hoof verbindings in rooibos en heuningbos onderskeidelik, is ondersoek t.o.v. glukuronidering en sulfonering. Glukuronidasie het gelei tot n verlies in antioksidant aktiwiteit van aspalatien en mangiferin soos bepaal in post-kolom HPLC-DAD-DPPH• en HPLC-DADABTS•+ toetse, asook verminderde interaksie met yster van mangiferin in die FRAP toets. Twee onafhanklike studies van 28 en 90 dae is onderneem met polifenol-verrykde ekstrakte (PVEs) van ongefermenteerde rooibos [Aspalathus linearis (PVR)] en heuningbos [Cyclopia. subternata (PVCsub) and C. genistoides (PVCgen)] in manlike Fisher rotte om die moontlike voordelige en/of nadelige biologiese effekte te ondersoek. PECgen was slegs in die 28 dae studie ingesluit. PVEs is gekarrakteriseer deur in vitro antioksidant en HPLC analises. Die belang van chemiese karaktirisering van rooibos en heuningbos tydens ondersoeke na biologiese aktiwiteit is duidelik aangesien verskeie en variërende biologiese aktiwiteite en verskille in die komposisie in die huidige studie gesien is. Die biologiese parameters wat ondersoek is om die effek van die PVEs te bepaal het serum kliniese parameters, aktiwiteit van geselekteerde ensieme, glutatioon en evaluering van die ekspressie van oksidatiewe en antioksidant verwante gene in die lewer, ingesluit. Sub-kroniese (90 dae) blootstelling van rotte aan PVR en PVCgen het yster absorpsie negatief beïnvloed. Die beduidende (P<0.05) verlaagde vlak van gereduseerde glutatioon in die lewer was toegeskryf aan die hoë vlakke van polifenole ingeneem tydens die studie en word moontlik veroorsaak deur n spesifieke katekol o-konjugasie van GSH. Hierdie interaksie was ook moontlik die oorsaak van n beduidende (P<0.05) toename in die aktiwiteit van glutatioon reduktase. Dié bevindinge het moontlike implikasies t.o.v die glutatioon homeostase en is n moontlike indikase dat PVEs van rooibos kan bydra tot oksidatiewe stres. PVCsub het veranderinge in die lewer gal-sisteem tot gevolg gehad aangesien daar n beduidende (P<0.05) verhoging in die serum totale bilirubin en alkalien fosfaat was. Hierdie veranderinge is beïnvloed deur die ouderdom, vlakke van die totale polifenole en die periode van blootstelling. Die uitdrukking van oksidatiewe en antioksidant verwante gene is op verskillende maniere beïnvloed deur die PVEs van rooibos en heuningbos in rot lewer and dien as n verdere indikasie van onderliggende oksidatiewe stres. Die modulerende effekte van PVEs op geenuitdrukking het gelei tot additionele insig aangaande die moontlike skadelike of beskermende eienskappe van PVEs vir gebruik as kruie produkte of dieet aanvullings. Die indikasies van moontlike oksidatiewe stres was duidelik van biologiese parameters en modulering van geenuitdrukking in die lewer, en vereis verdere ondersoek na die polifenool dosis en periode van toediening voordat PVEs van rooibos en heuningbos as funksionele voedsel produkte gebruik word. Hierdie ondersoek sowel as toekomstige ondersoeke in hierdie verband sal van waarde wees vir regulatoriese vereistes omtrent die veiligheid en effektiwiteit van rooibos en heuningbos kruie produkte.
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Wickens, Nicolas John. "Histopathological changes in male wistar rats maintained on a water-based sutherlandia frutescens extract." Thesis, Nelson Mandela Metropolitan University, 2012. http://hdl.handle.net/10948/4742.

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In this study a standardized 46 week chronic drinking water toxicity protocol was used to elucidate the toxic potential of Sutherlandia frutescens (S. frutescens) using histopathologic, morphometric and transmission electron microscopic analysis. The histopathologic changes in the duodenum, heart, kidney, liver, lung, pancreas and spleen of male Wistar rats were evaluated. Fifty-four rats were randomly divided into four groups: Group 1 – Normal diet control (ND control), n=7, Group 2 – Normal diet + plant extract (ND + p), n=9, Group 3 – High fat diet control (HFD control), n=19Group 4 – High fat diet + p (HFD + p), n=19In the high fat group male Wistar rats were fed ±55 g/day of a specialised high fat diet over a 46 week period to induce obesity and an insulin resistant state. The treatment groups (groups 2 and 4) received a dose concentration of a tea extract of the S. frutescens plant in their drinking water daily. This study showed that the consumption of S. frutescens significantly reduces weight gain in male Wistar rats on a chronic high fat diet (p≤0.001 vs. HFD control group). S. frutescens appears to propagate periportal and centrilobular glycogen storage in rat hepatocytes in the experimental groups as exemplified by a significantly (p≤0.0001 vs. control groups) increased incidences of Periodic Acid Schiff (PAS) positive staining S. frutescens also reduced intracellular lipid accumulation as made evident by the significantly lower incidence of epicardial adipose tissue (EAT), hepatic steatosis and pancreatic interstitial fat. Obesity was associated with increased fibrotic lesions such as myocardial perivascular fibrosis, centrilobular hepatic fibrosis and pancreatic periductal fibrosis. Obesity associated hypertension contributed to the widespread and significant increase in the average lesion severity of arterial congestion in all organs in the HFD control group. Pulmonary infection was equally prevalent in all rats. Despite the complex histopathology in all groups, differences in the control groups, such as, the presence of a conservative polymorphonuclear leukocyte (PMNL) infiltration, substantial intra-alveolar oedema and focal arterial wall hypertrophy in the control groups was highly suggestive of Sendai viral infection. However histopathologic evidence, in the treatment groups, suggested chronic recurrent viral infection with superimposed Mycoplasma pulmonis (M. pulmonis) bacterial infection. The impact of advanced suppurative pulmonary infection was widespread and exemplified by increased lesion incidences of spontaneous murine progressive cardiomyopathy (MCP) and spontaneous chronic progressive nephropathy (CPN) among others. In conclusion S. frutescens administered for 46 weeks to male Wistar rats significantly lowered intracellular lipid accumulation and obesity associated myocardial, renal, hepatobiliary, pulmonary and pancreatic histopathology. Moreover, duodenal, cardiovascular, hepatobiliary, pulmonary, renal, pancreatic and splenic tissue did not show histopathologic evidence of direct plant extract associated toxicity or carcinogenicity.
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Xu, Cen Reith Maarten E. A. "Cocaine and the dopamine transporter." Normal, Ill. Illinois State University, 1996. http://wwwlib.umi.com/cr/ilstu/fullcit?p9721400.

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Thesis (Ph. D.)--Illinois State University, 1996.
Title from title page screen, viewed May 30, 2006. Dissertation Committee: Maarten E. A. Reith (chair), Hou Tak Cheung, John W. Dailey, Robert L. Preston, Brian J. Wilkinson. Includes bibliographical references and abstract. Also available in print.
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Connolly, Ashley Rex. "Cytokine gene expression in a rat model of polyarthritis /." Title page, contents and abstract only, 1998. http://web4.library.adelaide.edu.au/theses/09PH/09phc75238.pdf.

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Books on the topic "Liver Rats as laboratory animals"

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Pharmakokinetik von 2-Nitropropan: Untersuchungen in vivo an Kaninchen, Untersuchungen in vitro an Leberfraktionen von Kaninchen und Ratte. Neuherberg: GSF-Forschungszentrum für Umwelt und Gesundheit, 1992.

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Sharp, Patrick. The laboratory rat. Boca Raton, Fla: CRC Press, 1998.

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Sharp, Patrick E. The laboratory rat. Edited by La Regina Marie C and Suckow Mark A. Boca Raton, Fla: CRC Press, 1998.

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1947-, Kolb Bryan, ed. The behavior of the laboratory rat: A handbook with tests. New York: Oxford University Press, 2005.

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1979-, Villano Jason, ed. The laboratory rat. 2nd ed. Boca Raton, FL: Taylor & Francis, 2013.

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Laboratory rat procedural techniques: Manual and DVD. Boca Raton: CRC Press, 2011.

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National Research Council (U.S.). Committee on Rat Nomenclature. Definition, nomemclature and conservation of rat strains. Washington, D.C: National AcademPress, 1993.

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Tucker, Mary J. Diseases of the Wistar rat. London: Taylor & Francis, 1997.

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Voipio, Hanna-Marja. Hiiren ja rotan tartuntataudit. Kuopio: Valtakunnallinen koe-eläinkeskus, Kuopion yliopisto, 1988.

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Dennis, Simone. For the love of lab rats: Kinship, humanimal relations, and good scientific research. Amherst, NY: Cambria Press, 2011.

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Book chapters on the topic "Liver Rats as laboratory animals"

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Cloutier, Sylvie. "Behavioral Biology of Rats." In Behavioral Biology of Laboratory Animals, 113–30. Boca Raton: CRC Press, 2021. http://dx.doi.org/10.1201/9780429019517-9.

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Kaliste, Eila, and Satu Mering. "The welfare of laboratory rats." In The Welfare of Laboratory Animals, 153–80. Dordrecht: Springer Netherlands, 2007. http://dx.doi.org/10.1007/978-1-4020-2271-5_8.

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Geise, W. "Guidelines for the Use and Care of Small Laboratory Animals in Transplantation Research." In Organtransplantation in Rats and Mice, 27–40. Berlin, Heidelberg: Springer Berlin Heidelberg, 1998. http://dx.doi.org/10.1007/978-3-642-72140-3_4.

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McInnes, Elizabeth F. "Wistar and Sprague–Dawley rats." In Background Lesions in Laboratory Animals, 17–36. Elsevier, 2012. http://dx.doi.org/10.1016/b978-0-7020-3519-7.00002-4.

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"Pathogens of Rats and Mice." In Natural Pathogens of Laboratory Animals, 19–107. Washington, DC, USA: ASM Press, 2014. http://dx.doi.org/10.1128/9781555817824.ch2.

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Würbel, Hanno, Charlotte Burn, and Naomi Latham. "The behaviour of laboratory mice and rats." In The ethology of domestic animals: an introductory text, modular texts, 217–33. 2nd ed. CABI, 2009. http://dx.doi.org/10.1079/9781845935368.0217.

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"LABORATORY EVALUATION OF LIVER DISEASE IN DOMESTIC ANIMALS." In Veterinary Clinical Pathology Secrets, 173–78. Elsevier, 2004. http://dx.doi.org/10.1016/b978-1-56053-633-8.50033-4.

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Sharp, Lesley A. "The Sentimental Structure of Laboratory Life." In Animal Ethos, 35–75. University of California Press, 2018. http://dx.doi.org/10.1525/california/9780520299245.003.0002.

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Chapter 1 is the first of two in part 1 of the book, “Intimacy.” A premise of this chapter is that intimate human-animal encounters are an inescapable, everyday aspect of lab work and that this intimacy engenders affective responses. Whereas regulatory apparati and associated research practices necessitate that animals be quantified in a host of ways (most evident in numbering and logging systems), still other practices abound that evidence how lab personnel understand animals as more than mere data points or objects of research. The underlying “sentimental structures” (a phrase long used in anthropology to reference kindredness) offer rich evidence of an affective, moral registry at work in labs. Further, different species engender different sorts of responses among lab professionals, a reality I describe as species preference, where iconic species of science (e.g., lab rats and mice, macaques) evidence this. The more specifically charismatic qualities of chimpanzees and dogs are especially powerful in this way, where affective responses can vary not only from one individual lab worker to another, but also within or across a lab’s labor hierarchy, consisting of researchers, animal technicians (also known as “caretakers”), and veterinarians.
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Albrecht, Katherine. "Microchip-Induced Tumors in Laboratory Rodents and Dogs." In Veterinary Science, 51–91. IGI Global, 2018. http://dx.doi.org/10.4018/978-1-5225-5640-4.ch004.

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This chapter reviews literature published in oncology and toxicology journals between 1990 and 2006 addressing the effects of implanted radio-frequency (RFID) microchips on laboratory rodents and dogs. Eleven articles were reviewed in all, with eight investigating mice and rats, and three investigating dogs. In all but three of the articles, researchers observed that malignant sarcomas and other cancers formed around or adjacent to the implanted microchips. The tumors developed in both experimental and control animals and in two household pets. In nearly all cases, researchers concluded that the microchips had induced the cancers. Possible explanations for the tumors are explored, and a set of recommendations for policy makers, human patients and their doctors, veterinarians, pet owners, and oncology researchers is presented in light of these findings.
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McCarty, Richard. "Post-Traumatic Stress Disorder." In Stress and Mental Disorders: Insights from Animal Models, 433–64. Oxford University Press, 2020. http://dx.doi.org/10.1093/med-psych/9780190697266.003.0014.

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Two especially valuable animal models of post-traumatic stress disorder (PTSD) have been developed, including brief exposure of laboratory rats to a predator (a cat) or its odor, and the single prolonged stress paradigm. In each of these models, laboratory animals are evaluated for behavioral changes several days to several weeks following the stressful experience and are compared to unstressed controls. In both of these models, stressed animals display behavioral changes consistent with a PTSD-like phenotype. Using these models, investigators have explored central and peripheral neural and endocrine changes associated with the onset of PTSD-like symptoms and approaches to prevent or block the effects of the traumatic stressor on behavioral changes. Two particularly effective treatments that have been described include administration of a protein synthesis inhibitor and intra-nasal administration of neuropeptide Y. Animal models also provide an opportunity to study transgenerational transmission of PTSD risk.
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Conference papers on the topic "Liver Rats as laboratory animals"

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Lanets, O. V., M. P. Semenenko, K. A. Semenenko, and L. V. Lazarevich. "ASSESSMENT OF THE INFLUENCE OF THE NEW STRESS CORRECTOR ON THE LABORATORY ANIMAL ORGANISM IN THE ACUTE EXPERIMENT." In STATE AND DEVELOPMENT PROSPECTS OF AGRIBUSINESS Volume 2. DSTU-Print, 2020. http://dx.doi.org/10.23947/interagro.2020.2.680-682.

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The article presents the results of acute toxicity of a new complex preparation in various ways of its introduction to laboratory white mice and rats. It was determined that a single intragastric and intramuscular administration of the maximum doses of the preparation does not cause a clinical picture of toxicosis and death of laboratory animals, on the basis of which the preparation is classified as hazardous class (GOST 12.1.007-76 “Harmful substances”) - low-hazard substances.
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Gerna, M., and M. B. Donati. "HYPERCOAGULABILITY AND REDUCED SENSITIVITY TO WARFARIN IN RATS FOLLOWING CAFFEINE INTAKE." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643399.

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The effect(s) of caffeine Intake on cardiovascular functions are still a matter of debate. We have considered here the level of the prothrombin complex activity as a parameter of blood coagulability following caffeine Intake. The activity of the four vitamin K-dependent clotting factors (II, VII, IX and X) was tested after acute and chronic administration of high doses of caffeine. With a single administration of 50 mg/kg caffeine a statistically significant increase in the activity of factors VII, IX and X was observed. The increase lasted for 4, 3 and 2 days respectively. Factor II was not affected by caffeine administration. The same effect was observed during chronic administration (50 mg/kg/day). With a lower dose of caffeine during chronic administration (5 mg/kg/day) only factor X showed a significant increase. A single dose of caffeine (50 mg/kg) given to animals 24h before-a dose of warfarin (0.4 mg/kg i.v.) markedly reduced the anticoagulant effect of warfarin, as measured by the thrombotest. During the latter experiment we measured also the rate of synthesis (Rsyn) of the prothrombin complex activity. Rsyn, during warfarin treatment, was significantly higher in the rats pretreated with caffeine than In controls. γ-Carboxylase activity in rat liver mlcrosomes was measured after administration of 50 mg/kg of caffeine as a single dose. The Incorporation of 14CO2 in the endogenous precursor was higher in the rats pretreated with caffeine than In controls (84,905 cpm/mg of protein versus 59,826 cpm/mg of proteins); this difference, however, was not statistically significant. In conclusion, caffeine jntake may affect the clotting system mainly by stimulating the synthesis of factors of the prothrombin complex and, as a consequence, their response to coumarin anticoagulation.
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Cerletti, C., M. C. Gombino, S. Possaghe, F. Bucchi, Z. M. Chen, and G. de Gaetano. "EFFECTS OF ORAL ASPIRIN ON PLATELET AND VASCULAR CYCLOOXYGENASE ACTIVITY IN RATS WITH PORTACAVAL SHUNT." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643417.

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Oral aspirin can be extensively hydrolysed to salicylate in stomach and liver before entering the systemic circulation. “Pre-systemic” acetylation of the platelets may thus occur during aspirin absorption. This may result in concomitant sparing of peripheral vascular cyclooxygenase mainly exposed to salicylate. We tested whether the “biochemical selectivity” of oral aspirin as an inhibitor of platelet vs. vascular cyclooxygenase would be reduced by elimination of the “first-pass” hepatic metabolism. A portacaval shunt was inserted in anaesthetized rats by connecting the portal vein to the inferior vena cava through a “Y” heparinized polyethylene PE 60-160 cannula. Sham operated rats acted as controls. 90 min after recovery from anaesthesia rats were given aspirin orally (10 mg/kg) and 45 min later serum TxB2 and 6-keto-PGF la formation by vascular rings were evaluated by radioimmunoassay. Serum TxB2 was completely suppressed in all animals; in contrast, vascular 6-keto-PGF la was significantly reduced (by 40-60* in aorta and vena cava) in rats with portacaval shunt but not in controls. The results in rats with portacaval shunt were similar to those previously obtained after i.v. aspirin. 15 min after aspirin administration, plasma levels of unmetabolized drug measured by HPLC were significantly higher in rats with portacaval shunt (0.56±0.16 μg/ml; n= 5) than in sham operated controls (0.16±0.22 }μg/ml; n= 5). This study directly supports the role of “ first-pass” hepatic metabolism in determining the “biochemical selectivity” of oral aspirin.
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Kolpakova, Valentina, Denis Kulikov, Ruzaliya Ulanova, Nikolay Lukin, and Irina Gaivoronskaya. "BIOCONVERSION OF CEREAL SERUM - A SECONDARY PRODUCT FOR PRODUCING PROTEIN CONCENTRATES FROM PEA AND CHICK PEAS." In GEOLINKS International Conference. SAIMA Consult Ltd, 2020. http://dx.doi.org/10.32008/geolinks2020/b1/v2/06.

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Studies on the bioconversion of whey water formed from chickpea and pea grains in the preparation of protein concentrates have been performed. The serum remaining after precipitation of the main part of the protein was subjected to a symbiotic transformation of Saccharomyces cerevisiae 121 and Geotrichum candidum 977 yeast cultures with the formation of protein-containing products with a mass fraction of protein (52.27-57.90% of DS) and a complementary amino acid composition. A microbial-plant concentrate was used as an additive in the feeding of Wistar laboratory rats. After 25 days of feeding, there was no negative effect on the physiological parameters and behavior of animals, which indicates the high quality of the protein product and the prospects of its inclusion in the composition of animal feed and diets.
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Sudirman, Muhamad Seto. "Effectiveness of Ficus Elastica Roxb. Ex Hornem Leaf Extract in Reducing Total Cholesterol Level in High Fat Induced Diet Wistar Male Rats." In The 7th International Conference on Public Health 2020. Masters Program in Public Health, Universitas Sebelas Maret, 2020. http://dx.doi.org/10.26911/the7thicph.05.10.

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ABSTRACT Background: Kebo rubber leaves (ficus elastica roxb) contain flavonoids, polyphenols, and tannins. Flavonoids in the leaves of ficus elastica roxb such as catechins, isoflavones are polyphenolic antioxidants from plant metabolites. The leaves of ficus elastica roxb are trusted and proven empirically in the community to reduce cholesterol levels in the blood. Mice choose animals because they are considered to have physiological similarities with humans. This study aimed to determine the effect of ethanol extract of ficus elastica roxb leaves on reducing total cholesterol level in male Swiss Webster mice. Subjects and Method: This was a quasi-experimental study conducted at Biology Laboratory of the Faculty of Agriculture, Fisheries and Biology, University of Bangka Belitung from April to June, 2017. A sample of 25 male Swiss Webster mice was selected at random and allocated into groups. The dependent variable was total cholesterol. The independent variable was the extract of ficus elastica rox. The data were tested by One-Way ANOVA. Result: There were statistically significant mean differences among the study groups (p= 0.002), indicating the effect of ethanol extract of Ficus Elastica Roxb leaves on reducing total cholesterol level in male Swiss Webster mice at various doses. Conclusion: There are statistically significant mean differences among the study groups, indicating the effect of ethanol extract of Ficus Elastica Roxb leaves on reducing total cholesterol level in male Swiss Webster mice at various doses. Keyword: Ethanol extract of Ficus Elastica Roxb leaves, total cholesterol, mice Correspondence: Muhamad Seto Sudirman. School of Health Polytechnic, Pangkalpinang. Email: MuhamadSeto@gmail.com DOI: https://doi.org/10.26911/the7thicph.05.10
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