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Journal articles on the topic 'LJ proportion method'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

HUANG, Zi-Kun, Qing LUO, Bi-Xia JIANG, et al. "Performance of the microscopic observation drug susceptibility assay in pyrazinamide susceptibility testing for Mycobacterium tuberculosis." Chinese Medical Journal 126, no. 22 (2013): 4334–39. http://dx.doi.org/10.3760/cma.j.issn.0366-6999.20130108.

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Background Drug susceptibility assay is very important in tuberculosis therapy. Pyrazinamide is a first line antituberculosis drug and diagnosis of its resistance in Mycobacterium tuberculosis (M. tuberculosis) is difficult and time consuming by conventional methods. In this study, we aimed to evaluate the performance of the microscopic observation drug susceptibility (MODS) assay in the detection of pyrazinamide resistance in M. tuberculosis relative to the conventional Wayne assay and Lowenstein-Jensen (LJ) proportion method. Methods M. tuberculosis clinical isolates (n=132) were tested by t

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Zadbuke, Sonali Sudhir, Reena Set, Nishat Khan, and Jayanthi Shastri. "Concurrent evaluation of microscopic observation of drug susceptibility assay for pulmonary and extrapulmonary tuberculosis." Journal of Laboratory Physicians 9, no. 02 (2017): 089–94. http://dx.doi.org/10.4103/0974-2727.199626.

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Abstract BACKGROUND: Methods for detection and drug susceptibility of tuberculosis (TB) with solid media are inexpensive but slow and laborious. Rapid methods to diagnose TB and multidrug-resistant TB (MDR-TB) are a global priority for TB control. OBJECTIVES: A study was performed to compare the sensitivity of detection of mycobacterial growth and time of culture positivity by microscopic observation of drug susceptibility (MODS) assay with that of Lowenstein–Jensen (LJ) culture in pulmonary and extrapulmonary TB and to evaluate the concordance of the susceptibilities to isoniazid (INH) and ri

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Wahyuningrum, Retno, Ritmaleni Ritmaleni, Tatang Irianti, Subagus Wahyuono, and Takushi Kaneko. "ANTITUBERCULOSIS ACTIVITY OF EXTRACT AND FRACTIONS OF TINOSPORA CRISPA AGAINST MYCOBACTERIUM TUBERCULOSIS H37RV USING MYCOBACTERIA GROWTH INDICATOR TUBE AND AGAR PROPORTION METHOD." Asian Journal of Pharmaceutical and Clinical Research 11, no. 3 (2018): 132. http://dx.doi.org/10.22159/ajpcr.2018.v11i3.22587.

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Objective: The increasing incidence of multidrug-resistant tuberculosis (TB) has created a need to discover a new anti-TB drug candidates. The aim of this study was to screen extract and fractions of Tinospora crispa for activity against Mycobacterium tuberculosis H37Rv.Methods: The dried and pulverized T. crispa stem was extracted by maceration method using ethanol (96%). The anti-TB activity was carried out using mycobacteria growth indicator tube (MGIT) system and agar proportion method with Lowenstein–Jensen (LJ) medium.Result: The result of this study showed that ethanolic extract and fra

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Lamsal, A., B. Thapa, M. Timilshina, SC Verma, GR Ghimire, and A. Gautam. "Direct Nitrate Reductase Assay for detection of drug resistance in Mycobacterium tuberculosis: rapid, simple and inexpensive method for low resource laboratories." International Journal of Infection and Microbiology 2, no. 2 (2013): 34–38. http://dx.doi.org/10.3126/ijim.v2i2.8319.

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INTRODUCTION: The most common method for detection of drug-resistant-Tuberculosis (DR-TB) in resource-limited settings (RLSs) is indirect susceptibility testing on Lowenstein-Jensen (LJ) medium with results available only after 2-3 months. Rapid detection of drug resistance by direct Nitatre Reductase Assay (NRA) expedites Tuberculosis patient management. The objective of the study is to access the feasibility and performance of Direct NRA for detection of DR-TB in National Tuberculosis Center under the National Tuberculosis Control Programme (NTP). MATERIALS AND METHODS: Out of 416 previously

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Yusuf, Roomi, Tehmeena Wani, Gulnaz Bashir, and Nargis Bali. "Drug Susceptibility Testing of M. tuberculosis to Isoniazid and Rifampicin- A Comparison between MTT Tube Method and LJ Proportion Method." British Journal of Medicine and Medical Research 9, no. 2 (2015): 1–6. http://dx.doi.org/10.9734/bjmmr/2015/18688.

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de Almeida, Isabela Neves, Suely Conceição Alves da Silva, Haliton Alves de Oliveira Junior, et al. "The Activity-Based Cost of Drug-Susceptibility Test of Mycobacterium tuberculosis Through Kit SIRE Nitratase® Plastlabor." International Journal of Mycobacteriology 9, no. 1 (2020): 24–28. http://dx.doi.org/10.4103/ijmy.ijmy_8_20.

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Background: Drug-resistant tuberculosis (TB) is an ongoing health threat, and the greatest challenge to adequate control of TB in many countries lies in the lack of proper laboratory drug-susceptibility test. The aim of this study was to evaluate the activity-based costs (ABC) of Kit SIRE Nitratase® (Kit SIRE) and compare its values with the conventional drug-susceptibility test. Methods: The ABC was calculated for three different approaches: Kit SIRE (clinical samples and cultures), proportion methods in Lowenstein Jensen (PM-LJ), and the Bactec™ MGIT™ 960 system based on Mycobacterial Resear

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Rahman, S. M. Mazidur, Md Fahim Ather, Rumana Nasrin, et al. "Performance of WHO-Endorsed Rapid Tests for Detection of Susceptibility to First-Line Drugs in Patients with Pulmonary Tuberculosis in Bangladesh." Diagnostics 12, no. 2 (2022): 410. http://dx.doi.org/10.3390/diagnostics12020410.

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The fast and accurate detection of susceptibility in drugs is a major challenge for a successful tuberculosis (TB) control programme. This study evaluated the performance of WHO-endorsed rapid diagnostic tools, such as BACTEC MGIT 960 SIRE (MGIT SIRE), GenoType MTBDRplus (MTBDRplus) and Xpert MTB/RIF (Xpert), for detecting susceptibility to first-line anti-TB drugs among pulmonary TB patients in Bangladesh. A total of 825 sputum samples with results from drug susceptibility testing (DST) against first-line anti-TB drugs in the MGIT SIRE, MTBDRplus and Xpert assays were evaluated and compared w

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K., Mamuda, S. Olonitola O., D. Jatau E., and Nicholas E. "Evaluation of Nitrate Reductase Assay for Detection of Multi-drug Resistant Mycobacterium tuberculosis among Patients at National Tuberculosis Reference Laboratory Zaria Nigeria." Journal of Advances in Medical and Pharmaceutical Sciences 14, no. 1 (2017): 1–7. https://doi.org/10.9734/JAMPS/2017/33705.

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<strong>Aims: </strong>To evaluate nitrate reductase assay for detection of multi-drug resistant <em>Mycobacterium tuberculosis</em> among patients at National Tuberculosis Reference Laboratory Zaria Nigeria. <strong>Study Design:</strong> Hospital based cross sectional study <strong>Place and Duration of Study:</strong> National Tuberculosis Reference Laboratory Zaria Nigeria from December 2015 to June 2016. <strong>Methodology:</strong> A total of 437 re-treatment patients’ samples were screened for Acid Fast Bacilli (AFB), 72 were smear positive. Out of 72 smears positive, 62 were culture p

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Zodape, G. V., S. N. Dharmashale, and V. S. Gaikwad. "Effect of Piper nigrum (Linn.) seeds extract and second line anti-tuberculosis drugs on a few Mycobacterium tuberculosis strains." Journal of Applied and Natural Science 13, no. 1 (2021): 402–6. http://dx.doi.org/10.31018/jans.v13i1.2497.

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Piper nigrum (Linn.) belonging to the family Piperaceae have been reported for its multitudinous medicinal values. The present study was undertaken to examine the direct effect of Ethionamide (ETH), Para amino salicylic acid (PAS), ethanolic extracts of P. nigrum on Mycobacterium tuberculosis (MTB) strain H37Rv and Multi drug-resistant (MDR)-strains-12, 19 and 21. The proportion method was used to detect the anti-mycobacterial drug susceptibility testing for mycobacteria using Lowenstein Jensen (LJ) medium. It was found that P. nigrum does not interfere with single or in the combination of bot

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Hu, Peilei, Liqiong Bai, Fengping Liu, et al. "Evaluation of the Xpert MTB/RIF assay for diagnosis of tuberculosis and rifampin resistance in county-level laboratories in Hunan province, China." Chinese Medical Journal 127, no. 21 (2014): 3744–50. http://dx.doi.org/10.3760/cma.j.issn.0366-6999.20141004.

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Background The Xpert MTB/RIF showed high sensitivity and specificity in previous studies carried out in different epidemiological and geographical settings and patient populations in high-burden tuberculosis (TB) countries. However, there were little data obtained by validation or demonstration study of the assay in China. In this study, the performance of Xpert MTB/RIF was investigated in two county-level laboratories in Hunan Province, China. Methods Consecutive patients with suspected pulmonary tuberculosis (PTB) and suspicion for multidrug-resistant tuberculosis (MDR-TB) were enrolled. For

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Oluwatosin, Ojetayo Helen, and Daniel Ugbomioko. "Clonal Diversity and Spatial Dissemination of Drug-resistant Mycobacterium tuberculosis Complex among HIV Seropositive Patients in Southwest Nigeria." Asian Journal of Research in Infectious Diseases 15, no. 12 (2024): 55–68. http://dx.doi.org/10.9734/ajrid/2024/v15i12400.

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Mycobacterium tuberculosis complex display relatively static genomes and 99.9% nucleotide sequence identity. Studying the evolutionary history of such monomorphic bacteria is a difficult and challenging task. Therefore, this study was undertaken to investigate the clonal diversity and spatial dissemination of drug-resistant M. tuberculosis complex among HIV seropositive clients in Southwest Nigeria. A total of two-hundred and seventeen (217) consented HIV positive (case subjects) and fifty (50) non-HIV positive controls were recruited for this study. Two Sputum samples were collected from each

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Fomda, Bashir Ahamd, Gulnaz Bashir, Sehrish Baqal, et al. "Rapid detection of drug-resistant Mycobacterium tuberculosis by Modified MODS assay suitable for resource-poor settings." PLOS Neglected Tropical Diseases 18, no. 1 (2024): e0011852. http://dx.doi.org/10.1371/journal.pntd.0011852.

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Background Cross contamination and biosafety are concerns with the microscopic observation drug susceptibility assay. To address these issues, we modified the MODS technique in the current study. Methodology/Principal findings Two hundred and seventy-five samples were processed on LJ media and drug susceptibility was performed by the Indirect agar proportion method. A modified MODS test was done in tissue culture bottles. GenoType MTBDRplus assay was performed to detect the resistance and mutational pattern associated with the resistances. Sensitivity, specificity, positive predictive value, a

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Getahun, Muluwork, Henry M. Blumberg, Gobena Ameni, Dereje Beyene, and Russell R. Kempker. "Minimum inhibitory concentrations of rifampin and isoniazid among multidrug and isoniazid resistant Mycobacterium tuberculosis in Ethiopia." PLOS ONE 17, no. 9 (2022): e0274426. http://dx.doi.org/10.1371/journal.pone.0274426.

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Introduction Traditionally, single critical concentrations of drugs are utilized for Mycobacterium tuberculosis (Mtb) drug susceptibility testing (DST); however, the level of drug resistance can impact treatment choices and outcomes. Mutations at the katG gene are the major genetic mutations in multidrug resistant (MDR) Mtb and usually associated with high level resistance. We assessed the minimum inhibitory concentrations (MICs) of MDR or rifampin resistant (RR) and isoniazid (INH) resistant Mtb isolates to determine the quantification of drug resistance among key anti-tuberculosis drugs. Met

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Aman, Munaza, Anjum Ara Mir, Gulnaz Bashir, Sayim Wani, Syed Khursheed, and Irfan Nisar Ahangar. "Evaluation of Colorimetric Nitrate Reductase Assay in Liquid Medium for Detection of Resistance to First-line Antitubercular Drugs." International Journal of Mycobacteriology 13, no. 2 (2024): 191–96. http://dx.doi.org/10.4103/ijmy.ijmy_69_24.

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Background: On a global scale, India holds the distinction of having the greatest number of tuberculosis (TB) cases caused by Mycobacterium tuberculosis (MTB) complex. The study aimed at evaluating the sensitivity, specificity, accuracy, cost, rapidity, and feasibility of the performance of the colorimetric nitrate reductase-based antibiotic susceptibility (CONRAS) test against the indirect proportion method (IPM) on Lowenstein–Jensen media as the gold standard. Methods: A comparative cross-sectional study was performed on 51 MTB isolates. Fresh subcultures were used for drug susceptibility te

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Umar, A., J. A. Hamza, Mujahid H., and P. Igba. "Comparative Studies of the Methods of Detecting Rifampicin Resistant Mycobacterium tuberculosis among Tuberculosis Patients Attending Aminu Kano Teaching Hospital, Kano." UMYU Journal of Microbiology Research (UJMR) 6, no. 2 (2021): 19–23. http://dx.doi.org/10.47430/ujmr.2162.003.

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This study was conducted to compare the specificity and sensitivity of GeneXpert MTB/Rif and Lowenstein-Jensen (LJ) Proportion methods of detecting rifampicin-resistant Mycobacterium tuberculosis among Acid Fast Bacilli (AFB) positive patients attending the Directly Observed Treatment (DOT) Centre of Aminu Kano Teaching Hospital Kano. A total of 150 AFB positive samples were collected and processed according to the guideline given by National TB and Leprosy Control Program (2015) and WHO (2012), The result revealed that rifampicin-resistant Mycobacterium tuberculosis (RR-TB) from the samples w

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Dahal, S., M. R. Banjara, D. Khadka, G. Ghimire, and S. Sharma. "Drug Susceptibility Profile of Mycobacterium tuberculosis Isolated from Patients Visiting National Tuberculosis Centre, Nepal." Tribhuvan University Journal of Microbiology 5 (September 26, 2018): 63–68. http://dx.doi.org/10.3126/tujm.v5i0.22314.

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Objectives: The objective of this study was to assess drug susceptibility pattern of Mycobacterium tuberculosis (MTB). Methods: This cross-sectional study was carried out among 145 clinically suspected and previously treated pulmonary tuberculosis patients visiting National Tuberculosis Centre, Bhaktapur, Nepal. After obtaining written informed consent, questionnaire was administered and sputum samples were collected from each patient. Each sample was subjected to Ziehl-Neelsen (ZN) staining and cultured on Lowenstein Jensen (LJ) medium at 37ºC for 8 weeks. MTB isolates were identified b

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Hudu, Shuaibu Abdullahi, Abdulgafar Olayiwola Jimoh, and Yahaya Mohammed. "Prevalence and Molecular Mapping of Multidrug-resistant Mycobacterium tuberculosis in Sokoto, North-Western Nigeria." Avicenna Journal of Clinical Microbiology and Infection 9, no. 3 (2022): 97–102. http://dx.doi.org/10.34172/ajcmi.2022.3390.

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Background: The emergence of multidrug-resistant tuberculosis tuberculosis (MDR-TB) poses a significant danger to Nigeria’s TB control efforts. Nigeria records 570000 new TB cases each year, and it is one of the world’s greatest TB-burden countries as well as one of the top ten countries with MDR-TB. This study aimed to determine the MDR prevalence, phylogenetic analysis, and molecular mapping as well as the link between MDR prevalence and demographic data. Methods: The study comprised 100 TB patients recruited consecutively. The proportion method on Lowenstein-Jensen (LJ) medium was used for

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Harun Prima, Boosra, Md Ehsanul Hoque, Shakeel Ahmed, et al. "Detection of Drug Resistance Pattern of Mycobacterium Tuberculosis by Genexpert MTB/RIF Solid and Liquid Culture in Extrapulmonary Tuberculosis." Chattagram Maa-O-Shishu Hospital Medical College Journal 23, no. 2 (2025): 65–68. https://doi.org/10.3329/cmoshmcj.v23i2.79751.

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Background: Tuberculosis (TB) remains one of the deadliest communicable diseases. Tuberculosis is caused by Mycobacterium tuberculosis and classified as Pulmonary Tuberculosis (PTB) and Extra Pulmonary Tuberculosis (EPTB). EPTB account for 15-20 % cases of tuberculosis. EPTB diagnosis is challenging due to inadequate sample volume, pauci-bacillary nature and unusual clinical presentation. There are number of tests available for the diagnosis of EPTB but conventional microscopy has low sensitivity and although culture is gold standard method, it takes longer time for yielding positive result. O

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Merza, Muayad Aghali, Parissa Farnia, Payam Tabarsi, Mehdi Khazampour, Mohammad Reza Masjedi, and Ali Akbar Velayati. "Anti-tuberculosis drug resistance and associated risk factors in a tertiary level TB center in Iran: a retrospective analysis." Journal of Infection in Developing Countries 5, no. 07 (2011): 511–19. http://dx.doi.org/10.3855/jidc.1259.

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Introduction: This study aimed to determine first-line anti-tuberculosis drug resistance rates in new and previously treated cases and to identify risk factors associated with multidrug resistant tuberculosis (MDR-TB) at the National Reference Tuberculosis Laboratory of Iran. Methodology: This was a retrospective analysis of all confirmed TB patients from December 2000 to June 2005. Drug susceptibility testing to isoniazid, rifampicin, streptomycin, ethambutol and pyrazinamide was performed on Löwenstein-Jensen (LJ) medium according to the proportion method. Results: Mycobacterium tuberculosis

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Girma, Samson, Zelalem Yaregal, Yosef Beyene, et al. "Non Tuberculosis Mycobacterium, E. coli and E. faecalis from Biofilm in Drinking Water Distribution Systems from Selected Sites of Addis Ababa." Open Microbiology Journal 13, no. 1 (2019): 171–76. http://dx.doi.org/10.2174/1874285801913010171.

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Background: The decline in microbial quality of drinking water may be attributed to many factors among which the presence of biofilm within the distribution system is the major cause of contamination. Drinking water distribution systems provide an oligotrophic environment, for post-treatment recovery and regrowth of microorganisms including the opportunistic Nontuberculosis Mycobacterium (NTM). Objective: The aim was to look for opportunistic non tuberculosis mycobacterium and indicator organisms of fecal contamination from biofilm in drinking water distribution pipeline from selected sites of

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Khadka, Dhruba Kumar, Rajendra Prasad Pant, Bikash Lamichhane, et al. "Identification of rpoB, gyrA and embB Gene Mutations in Mycobacterium Tuberculosis Isolates from Retreatment Tuberculosis Patients in Nepal." SAARC Journal of Tuberculosis, Lung Diseases and HIV/AIDS 14, no. 2 (2018): 39–50. http://dx.doi.org/10.3126/saarctb.v14i2.19336.

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Introduction: Tuberculosis remains one of the major public health problems in Nepal and increasing trend of multi drug resistant and extensively drug resistant tuberculosis (MDR /XDR TB) is a big challenge. Rapid diagnosis and appropriate treatment of MDR/XDR TB is crucial. Identification and comparison of MDR TB using rapid molecular techniques (for rpob, gyrA, rrs and embB gene mutations) with reference to drug susceptibility test (DST) were the main objectives of this study.Methodology: A cross sectional study was carried out in National TB Centre (NTC). Gene Xpert, proportion method and Li

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Safitri, Ratu, Ida Indrawati, Mas Rizky A. A. Syamsunarno, Mohammad Ghozali, Basri A Gani, and Ramdan Panigoro. "ANTI-MYCOBACTERIUM TUBERCULOSIS STRAIN H37RV AND IRON CHELATION ACTIVITY OF SAPPAN WOOD EXTRACT (CAESALPINIA SAPPAN L.) IN VITRO." Asian Journal of Pharmaceutical and Clinical Research 11, no. 6 (2018): 444. http://dx.doi.org/10.22159/ajpcr.2018.v11i6.25303.

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Objective: The objective of this study is to determine anti-Mycobacterium tuberculosis (MTB) strain H37Rv and iron chelation activities of sappan wood extract (SWE).Methods: The evaluation of minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) by proportion methods. Whereas the iron chelate in Lowenstein–Jensen (LJ) medium as the indicator of Mycobacterium growth and SWE effect.Results: The SWE has bacteriocidal to MTB of 10−3 and 10−5 dilutions in of all concentrations (250, 500, 750, 1000, 2000, 4000, 8000, and 16000 part per millions [ppm]) also bacteriostati

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Sekar, Gomathi, R. Lakshmi, and N. Selvakumar. "The Assessment of Viability of M. Tuberculosis after Exposure to CPC Using Different Methods." International Journal of Bacteriology 2014 (January 28, 2014): 1–5. http://dx.doi.org/10.1155/2014/564109.

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Settings. National Institute for Research in Tuberculosis, Chennai. Objective. To assess the proportion of metabolically active cells of Mycobacterium tuberculosis after exposed to CPC using FDA-EB vital staining and viable counts on LJ medium. Mycolic acid content in M. tuberculosis after exposure to CPC was estimated using HPLC. Methods. Clinical isolates of M. tuberculosis and standard reference strain M. tuberculosis H37Rv were used for FDA-EB, viable count, and HPLC. Results. FDA/EB consistently stained 70–90% of log phase cells as green and the remaining cells as red-orange. After CPC tr

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Wasifuddin, Mustafa, Nosakhare Paul Ilerhunmwuwa, Henry Becerra, et al. "Survival Trends in Diffuse Large B-Cell Lymphoma (DLBCL) in the CAR-T Cell Therapy Era Vs Pre-CAR-T Cell Therapy Era in the United States: A Population-Based Study." Blood 142, Supplement 1 (2023): 3765. http://dx.doi.org/10.1182/blood-2023-181377.

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Background Chimeric Antigen Receptors (CARs) are novel engineered proteins that alter T-cell antigen specificity. CAR-T cell therapy is a novel form of immunotherapy that uses T-cells engineered with CARs to target tumor-associated antigens. The Food and Drug Administration (FDA) granted approval to the first CAR-T therapeutic agents in 2017. Axicabtagene ciloleucel (axicel) is one such therapy currently in use that was developed to target CD19 - a pan-B cell marker for the treatment of Diffuse Large B-Cell Lymphoma (DLBCL). 1 Previous population-based studies have shown improvements in Overal

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Sreelatha, S., and George Kalpana. "Rapid Detection of Drug Resistant Pulmonary Tuberculosis by Line Probe Assay at a Tertiary Care Centre in North Kerala." International Journal of Toxicological and Pharmacological Research 13, no. 1 (2023): 160–70. https://doi.org/10.5281/zenodo.11311649.

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<strong>Background:</strong> Early detection of Isoniazid (INH) and rifampicin resistance is essential for treatment and control of multidrug resistant tuberculosis (MDR-TB). Conventional method will take about 8-10 weeks for culture and drug susceptibility tests (DST). MTBDR plus VER 2.0 Line probe assay (LPA) can be used for identification of <em>Mycobacterium tuberculosis</em> complex (MTB complex) and to detect drug resistance of INH and Rifampicin. <strong>Materials and Methods:</strong> Cross sectional study was conducted in 100 smear positive patients with clini

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Pollio, Berardino, Maria Messina, Irene Ricca, et al. "Perioperative Bleeding Risk Assessment in a Cohort of Children with Low Levels of Von Willebrand Factor." Blood 134, Supplement_1 (2019): 2400. http://dx.doi.org/10.1182/blood-2019-130023.

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Background: Identifying perioperative bleeding risk in pediatric patients undergoing major surgery is challenging because personal history is often not sufficiently informative and laboratory tests are also more susceptible to pre-analytical variables. Children with low Willebrand add further uncertainty in the treatment options. The aim of this study was to evaluate practices to assess hemorrhagic risk and manage bleeding prophylaxis in children with low von Willebrand factor levels (30 and 50 IU/dL; low VWF), known von Willebrand disease (VWD) or healthy controls undergoing ear, nose and thr

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Liu, Qiao, Dandan Yang, Beibei Qiu, et al. "Drug resistance gene mutations and treatment outcomes in MDR-TB: A prospective study in Eastern China." PLOS Neglected Tropical Diseases 15, no. 1 (2021): e0009068. http://dx.doi.org/10.1371/journal.pntd.0009068.

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Background Multidrug-resistant tuberculosis (MDR-TB) poses a serious challenge to TB control. It is of great value to search for drug resistance mutation sites and explore the roles that they play in the diagnosis and prognosis of MDR-TB. Methods We consecutively enrolled MDR-TB patients from five cities in Jiangsu Province, China, between January 2013 and December 2014. Drug susceptibility tests of rifampin, isoniazid, ofloxacin, and kanamycin were routinely performed by proportion methods on Lowenstein–Jensen (LJ) medium. Drug resistance-related genes were sequenced, and the consistency of g

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Lolong, Dina Bisara, Ni Ketut Aryastami, Ina Kusrini, et al. "Nonadherence to anti-tuberculosis treatment, reasons and associated factors among pulmonary tuberculosis patients in the communities in Indonesia." PLOS ONE 18, no. 8 (2023): e0287628. http://dx.doi.org/10.1371/journal.pone.0287628.

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Background Tuberculosis (TB) is the world’s major public health problem. We assessed the proportion, reasons, and associated factors for anti-TB treatment nonadherence in the communities in Indonesia. Methods This national coverage cross-sectional survey was conducted from 2013 to 2014 with stratified multi-stage cluster sampling. Based on the region and rural-urban location. The 156 clusters were distributed in 136 districts/cities throughout 33 provinces, divided into three areas. An eligible population of age ≥15 was interviewed to find TB symptoms and screened with a thorax x-ray. Those wh

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Kabedi, Marie José Bajani, Steve Mundeke Ahuka, Octavie Metila Lunguya, et al. "Profil Phénotypique et génotypique des souches de Mycobacterium tuberculosis résistants aux antituberculeux des contacts familiaux versus cas- index à Kinshasa, en République démocratique du Congo." Annales Africaines de Medecine 16, no. 3 (2023): 5156–65. http://dx.doi.org/10.4314/aamed.v16i3.2.

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Context and objective. Drug-resistant tuberculosis (DR-TB) has a major impact on patient treatment outcomes. The strategies put in place for its control involve early diagnosis and appropriate treatment of patients. The objective of the present study was to determine the phenotypic and genotypic profile of Mycobacterium tuberculosis strains from family contacts and their index cases in Kinshasa, Democratic Republic of Congo (DRC). Methods. This was a descriptive cross-sectional study that took place in Kinshasa (DRC) from July 2011 to August 2017. It consisted in analyzing strains of M.

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Graceffa, D., V. Lora, A. Cristaudo, F. Elia, A. Morrone та C. Bonifati. "AB0563 DISCONTINUATION OF ANTI-TNFα IN PATIENTS WITH PSORIATIC ARTHRITIS: A SINGLE-CENTER EXPERIENCE". Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 1318.1–1318. http://dx.doi.org/10.1136/annrheumdis-2021-eular.3002.

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Background:TNF inhibitors have been largely demonstrated to be effective and reasonably safe for the treatment of psoriatic arthritis (PsA). Current EULAR guidelines recommend the use of an anti-TNF as first choice treatment in patients with PsA for whom a synthetic DMARD (usually methotrexate or leflunomide) is not efficacious or not well tolerated [1]. In a scenario where biologic treatments are easily available, and the treat to target strategy is widely accepted, a complete disease remission or at least a minimal disease activity are considered realistic goals to be achieved in a growing p

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Dahiya, Saurabh, Ashley C. Saunders, Jinender Kumar, William Ngantung, and Matia Saeedian. "Cost Consequence and Time Toxicity Model for the Treatment of Third-Line or Later (3L+) Follicular Lymphoma (FL) Using Advanced Therapies: A Comparison of Lisocabtagene Maraleucel (liso-cel) with Mosunetuzumab." Blood 144, Supplement 1 (2024): 3651. https://doi.org/10.1182/blood-2024-201611.

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Background: FL is an incurable but manageable form of NHL that involves long-term management, frequent relapses, and multiple lines of therapy, which contribute to a serious burden on patients. Liso-cel, an autologous, CD19-directed, 4-1BB CAR T cell product, and mosunetuzumab, a CD20×CD3 bispecific antibody, are treatments for adults with R/R FL who have had ≥ 2 previous lines of systemic therapy. Liso-cel involves a 1-time infusion; mosunetuzumab typically involves 8-17 infusions but is more readily available than liso-cel. Economic, clinical, and quality of life outcomes are commonly analyz

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Ramírez, Diego Ontiveros, Brizio Moreno Jaime, José Luis González Trujillo, Carlos Alberto Ramírez Alvarado, Paulina Martínez Valadez, and Mario Alberto Ramírez González. "Abstract P1-05-12: The 70-Gene Signature Assay vs. Traditional Clinical Risk Assessment: Impact on Adjuvant Chemotherapy Choices in Mexican Breast Cancer Patients." Clinical Cancer Research 31, no. 12_Supplement (2025): P1–05–12—P1–05–12. https://doi.org/10.1158/1557-3265.sabcs24-p1-05-12.

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Abstract Introduction: Breast cancer is the most frequent malignant neoplasm in mexican women; it is a complex disease with diverse clinical outcomes and multiple responses to treatment (1). Adjuvant systemic treatment decreases the risk of developing distant metastasis and death by approximately 30% in patients with node-negative breast cancer, but 70% of all patients on adjuvant therapy will experience toxicity without benefit from such treatment (2,3). Tools including St Gallen, NIH guidelines, risk calculators (PREDICT) or indexes such as the Nottingham Prediction Index are currently used

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Amuda, Bosede Oyewumi, O. O. Oduyebo, and Philip Abutu. "Detection of Multi-Drug Resistant Tuberculosis Using the Genotype MTBDR DNA Strip Assay and Lowenstein Jensen Proportion Method." Asian Journal of Research in Infectious Diseases, June 25, 2020, 11–22. http://dx.doi.org/10.9734/ajrid/2020/v4i230142.

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Pulmonary tuberculosis (TB) remains a significant public health issue in low-middle income countries. Accurate and timely diagnosis is key to effective management. Diagnosing Multi Drug Resistance Tuberculosis (MDR-TB) is mostly done with phenotypic Lowenstein Jenson (LJ) proportion method with long turn around which delays treatment. The genotypic MTBDR plus was introduced by World Health Organisation (W.H.O) for the same purpose hence, this study aims to detect MDR-TB using both two methods. Sputum samples were collected from cases of pulmonary TB diagnosed with Genexpert and Ziehl Neelsen s

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Mohan, Nitin, Indugula Jyothi Padmaja, Ratna Harika Dusi, and Kancharla Suresh. "STUDY OF RESISTANCE TO FIRST-LINE DRUGS IN MULTIDRUG RESISTANCE TUBERCULOSIS SUSPECTS FROM SPUTUM SAMPLES BY GOLD STANDARD – STANDARD ECONOMIC VARIANT 1% PROPORTION METHOD IN NORTH COASTAL ANDHRA PRADESH." Asian Journal of Pharmaceutical and Clinical Research, October 7, 2022, 127–30. http://dx.doi.org/10.22159/ajpcr.2022.v15i10.45521.

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Objectives: The objectives of the study were to culture Mycobacterium tuberculosis from sputum samples of multidrug resistance (MDR) suspects on Lowenstein-Jensen (LJ) media, to test for susceptibility and resistance to first-line antitubercular drugs rifampicin (RMP), isoniazid (INH), streptomycin (SM), and ethambutol (EMB) by conventional DST on LJ media by standard economic variant proportion (1%) method and to calculate the rate of MDR and pattern of drug resistance in MDR tuberculosis (MDR-TB) suspects. Methods: A prospective, laboratory-based study was done on a total of 80 samples from

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Olonishuwa, Paul T., Gabriel O. Anyanwu, and Uju D. I. Ejike. "Antitubercular activities, antioxidant properties and GCMS fingerprinting of Acacia hebecladoides, Acacia albida and Gmelina arborea." Annals of Science and Technology, November 16, 2022. http://dx.doi.org/10.2478/ast-2022-0009.

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Abstract Background: It is a practice to use traditional medicine for curing various illnesses in West Africa. Acacia hebecladoides, Acacia albida and Gmelina arborea were selected based on their traditional belief for treating various ailments such as: hallucinations, inflammation and tuberculosis. The study sought to validate the antitubercular activity, antioxidant properties and phytochemical components of extracts and fractions of the leaves of selected plants. Method: The antitubercular activities of the plants were evaluated against Mycobacterium tuberculosis (MTB), multidrug-resistant

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Mauliku, Novie Elvinawaty. "The Anti-tubercular Activity of Noni Fruitsto Inhibition Growth of Multi Drug Resistant-Tuberculosis Bacteria." KnE Life Sciences, March 15, 2021, 979–90. http://dx.doi.org/10.18502/kls.v6i1.8774.

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Multidrug-resistant tuberculosis (MDR-TB) is a tuberculosis infection that is resistant to the treatment at least two of the most powerful anti-tuberculosis drugs, such as Isoniazid and Rifampisin. Increased cases of MDR-TB in morbidity and mortality become obstacles in the control of tuberculosis (TB), thus requiring supportive treatment of natural ingredients that can contribute in the treatment of TB, such a noni fruit. The main objective of this study was extract of noni fruits to inhibition the growth of strain MDR-TB bacteria, and compered it with the anti-TB drugs. The Morinda c. Linn (

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Ssengooba, Willy, Achilles Katamba, James Sserubiri, et al. "Performance evaluation of Truenat MTB and Truenat MTB-RIF DX assays in comparison to gene XPERT MTB/RIF ultra for the diagnosis of pulmonary tuberculosis in Uganda." BMC Infectious Diseases 24, no. 1 (2024). http://dx.doi.org/10.1186/s12879-024-09063-z.

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Abstract Background The World Health Organization endorsed Truenat MTB rapid molecular assay in 2020 and recommended additional in-country evaluation studies before uptake. We evaluated the accuracy and operational feasibility of Truenat MTB assay (Truenat) in comparison with GeneXpert Ultra and culture. Methods In a cross-sectional study of 250 presumptive TB patients, participants were requested to provide a sputum sample on the day of their visit to the clinic. The sputum sample was homogenized and a portion was tested using GeneXpert Ultra as per the routine standard procedure and the othe

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Namugenyi, Juliet, Joseph Musaazi, Achilles Katamba, et al. "Baseline Xpert MTB/RIF ct values predict sputum conversion during the intensive phase of anti-TB treatment in HIV infected patients in Kampala, Uganda: a retrospective study." BMC Infectious Diseases 21, no. 1 (2021). http://dx.doi.org/10.1186/s12879-021-06220-6.

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Abstract Background In resource-limited settings, sputum smear conversion is used to document treatment response. Many People living with HIV (PLHIV) are smear-negative at baseline. The Xpert MTB/RIF test can indirectly measure bacterial load through cycle threshold (ct) values. This study aimed to determine if baseline Xpert MTB/RIF could predict time to culture negativity in PLHIV with newly diagnosed TB. Methods A subset of 138 PLHIV from the ‘SOUTH’ study on outcomes related to TB and antiretroviral drug concentrations were included. Bacterial load was estimated by Mycobacterium Growth Ind

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Hrychaniuk, D. A., D. Yu Ladutko, A. V. Pekar, and A. N. Liashchynski. "Fibular reconstruction of the mandible in fibrous dysplasia." Head and neck. Russian Journal 11, no. 2 (2023). https://doi.org/10.25792/hn.2023.11.2.44-51.

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Fibrous dysplasia is a disease characterized by fibro-osseous osteopathy in which normal bone is replaced by fibrous tissue and non-functioning bony structures, e.g., trabeculae. In the head and neck area, monostotic or polyostotic lesions cause a progressive increase in destructive bone edema, which leads to cosmetic defects and functional disorders. The lower jaw is anatomically the most important structural and functional component of the lower zone of the facial skull. Pedicled fibula flap is the gold standard among the flaps in reconstructive surgery. Traditional planning methods, anatomi

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