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Macias-Escobar, Teodoro, Laura Cruz-Reyes, Bernabé Dorronsoro, Héctor Fraire-Huacuja, Nelson Rangel-Valdez, and Claudia Gómez-Santillán. "APPLICATION OF POPULATION EVOLVABILITY IN A HYPER-HEURISTIC FOR DYNAMIC MULTI-OBJECTIVE OPTIMIZATION." Technological and Economic Development of Economy 25, no. 5 (July 12, 2019): 951–78. http://dx.doi.org/10.3846/tede.2019.10291.
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It is important to know the properties of an optimization problem and the difficulty an algorithm faces to solve it. Population evolvability obtains information related to both elements by analysing the probability of an algorithm to improve current solutions and the degree of those improvements. DPEM_HH is a dynamic multi-objective hyper-heuristic that uses low-level heuristic (LLH) selection methods that apply population evolvability. DPEM_HH uses dynamic multiobjective evolutionary algorithms (DMOEAs) as LLHs to solve dynamic multi-objective optimization problems (DMOPs). Population evolvability is incorporated in DPEM_HH by calculating it on each candidate DMOEA for a set of sampled generations after a change is detected, using those values to select which LLH will be applied. DPEM_HH is tested on multiple DMOPs with dynamic properties that provide several challenges. Experimental results show that DPEM_HH with a greedy LLH selection method that uses average population evolvability values can produce solutions closer to the Pareto optimal front with equal to or better diversity than previously proposed heuristics. This shows the effectiveness and feasibility of the application of population evolvability on hyperheuristics to solve dynamic optimization problems.
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Silva-Souza, Lucas Geazi da, Luana Domingos de Oliveira, Gabriel Pereira Nunes, Laila dos Santos Cividanes, Cristian Michael Dahan, Andressa Kleyslla Guedes Pereira, Dárcio Kitakawa, Viviana Moraes Neder, and Luis Felipe das Chagas e. Silva de Carvalho. "Effectiveness of the low-level laser therapy in the management of bisphosphonate-induced osteonecrosis of the jaws: A case report." Research, Society and Development 10, no. 6 (May 24, 2021): e17510615199. http://dx.doi.org/10.33448/rsd-v10i6.15199.
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The aim of this study was to report a clinical case of osteonecrosis caused by bisphosphonates and its treatment with the aid of laser therapy. Low-level laser therapy (LLLT) is a resource used that is characterized by photobiostimulation and photobiomodulation, promoting analgesia and anti-inflammatory effects and can also be a tool for treating osteonecrosis induced by bisphosphonates (BFs), when associated also to drug therapy. The present case is a 63-year-old patient, leukoderma, with thyroid disorder and osteoporosis, making continuous use of medicaments classified as BF’s. He had a dental fracture and sensitivity to cold and treatment started with prophylaxis. After radiography of the dental elements, restorations were performed and tooth extraction (element 46). In the postoperative period, the patient reports pain and a bone exposure were observed clinically in the region of the extracted area, with osteonecrosis being diagnosed. Drug therapy was promptly applied and the use of LLLT was chosen as an adjunctive and supportive therapy. It is plausible to infer the need for attention to patients undergoing drug treatment with bisphosphonates, fully evaluating the best treatment for the possible occurrence of osteonecrosis in view of LLT as an effective complementary therapeutic approach.
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de Alencar F. Santos, Joelita, Renata Nicolau, Luciana Sant’Anna, Josne Paterno, Priscila Cristovam, Jose Gomes, José Santos, and Emilia Arisawa. "Diabetic Foot Wounds Treated With Human Amniotic Membrane and Low-level Laser Therapy: A Pilot Clinical Study." Wound Management & Prevention 67, no. 8 (August 10, 2021): 16–23. http://dx.doi.org/10.25270/wmp.2021.8.1623.
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BACKGROUND: Low-level laser therapy (LLLT) and human amniotic membrane (HAM) application have been shown to be viable options for use in wound healing. PURPOSE: This study sought to compare LLLT and HAM to a control treatment (hydrogel, saline, and gauze) in persons with diabetes mellitus (DM) and foot ulcers. METHODS: Using a prospective pilot clinical study design, patients receiving care at a health center that specializes in the treatment of diabetic foot wounds between November 2016 and August 2017 were recruited. Eligible patients had to be 30 to 59 years of age; diagnosed with type 2 DM (postprandial capillary glucose levels between 140 and 350 mg/dL); and have uninfected, granulating stage 2 or 3 foot ulcers measuring less than 7 cm by 3 cm. Immunosuppressed and malnourished patients or those with neoplasms or in critical condition were not eligible to participate. Patients received the control treatment (2 mg hydrogel, saline, and gauze), HAM (patches of thawed HAM, applied with overlapping edges), or LLLT (phototherapy session, 2 mg hydrogel, saline, and gauze) for 28 days. Variables, wound area measurements, Pressure Ulcer Scale for Healing (PUSH) scores, and Visual Analog Scale (VAS) scores were used to assess wound improvement progress and pain on days 7, 14, 21, and 28. Descriptive statistics were used to analyze the participant anthropometric and clinical profiles. The Kolmogorov-Smirnov test was used to analyze the sample distribution. The Kruskal-Wallis test with Dunn’s post-test was used to evaluate differences in PUSH and VAS scores and wound size for intergroup analysis, and the Mann-Whitney U test was used for the same outcomes in intragroup analysis. The level of significance was 5% (P < .05). RESULTS: Twenty-seven (27) patients participated (mean age, 51.4 years; mean body mass index, 26.5 kg/m2), with 9 patients in each treatment group. No statistically significant differences were noted in clinical or anthropometric variables among the groups, but mean baseline wound areas were different (2.6 cm² for the control, 1.9 cm² for the LLLT, and 5.5 cm² for the HAM groups). Intragroup comparisons showed a significant reduction in PUSH score in the LLT group between days 0 and 21 (8.2 vs 4.9; P < .01) and days 21 to 28 (4.9 vs 3.2; P < .001). In all treatment groups the percent reduction was significantly different between days 7 and 28. No outcomes were significantly different between groups. CONCLUSION: Diabetic foot ulcer wound area as well as PUSH and VAS scores showed more improvement for patients with DM receiving LLLT or HAM than for the control group, but the differences were not significant. Larger studies are needed to compare these treatment modalities.
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Lanferdini, Fábio J., Rodrigo R. Bini, Bruno M. Baroni, Kelli D. Klein, Felipe P. Carpes, and Marco A. Vaz. "Improvement of Performance and Reduction of Fatigue With Low-Level Laser Therapy in Competitive Cyclists." International Journal of Sports Physiology and Performance 13, no. 1 (January 1, 2018): 14–22. http://dx.doi.org/10.1123/ijspp.2016-0187.
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Evidence indicates that low-level laser therapy (LLLT) minimizes fatigue effects on muscle performance. However, the ideal LLLT dosage to improve athletes’performance during sports activities such as cycling is still unclear. Therefore, the goal of this study was to investigate the effects of different LLLT dosages on cyclists’performance in time-to-exhaustion tests. In addition, the effects of LLLT on the frequency content of the EMG signals to assess fatigue mechanisms were examined. Twenty male competitive cyclists participated in a crossover, randomized, double-blind, placebo-controlled trial. They performed an incremental cycling test to exhaustion (on day 1) followed by 4 time-to-exhaustion tests (on days 2–5) at their individual maximal power output. Before each time-to-exhaustion test, different dosages of LLLT (135, 270, and 405 J/thigh, respectively) or placebo were applied at the quadriceps muscle bilaterally. Power output and muscle activation from both lower limbs were recorded throughout the tests. Increased performance in time-to-exhaustion tests was observed with the LLLT-135 J (∼22 s; P < .01), LLLT-270 J (∼13 s; P = .03), and LLLT-405 J (∼13 s; P = .02) compared to placebo (149 ± 23 s). Although LLLT-270 J and LLLT-405 J did not show significant differences in muscle activation compared with placebo, LLLT-135 J led to an increased high-frequency content compared with placebo in both limbs at the end of the exhaustion test (P ≤ .03). In conclusion, LLLT increased time to exhaustion in competitive cyclists, suggesting this intervention as a possible nonpharmacological ergogenic agent in cycling. Among the different dosages, LLLT-135 J seems to promote the best effects.
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Barger, Brenna K., Adam M. Bisges, Derek B. Fox, and Bryan Torres. "Low-Level Laser Therapy for Osteoarthritis Treatment in Dogs at Missouri Veterinary Practice." Journal of the American Animal Hospital Association 56, no. 3 (May 1, 2020): 139–45. http://dx.doi.org/10.5326/jaaha-ms-6851.
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Abstract A qualitative survey was electronically distributed to practicing veterinarians in the state of Missouri to evaluate the frequency of use and economic impact of low-level laser therapy (LLLT) for the treatment of osteoarthritis (OA) in dogs in Missouri. The survey response rate was 10% (89/867). Approximately half (43%) of respondents had LLLT units, of which all used LLLT for OA treatment in dogs. In respondents without LLLT units, 20% referred patients for LLLT OA treatment. Training was most often obtained in-house by a representative of the LLLT unit manufacturer (76%). Treatment dose was largely unknown and chosen by predetermined settings on the LLLT unit (65%). In the majority of patients (84%), no treatment site preparation was performed. An average of four patients with OA were treated per wk with an average cost per treated joint of $28 (range: $15–45). This study provides insight into the current clinical use and estimated annual economic impact ($6.2 million per year) of treating a single OA joint in dogs with LLLT by Missouri veterinarians. The frequency with which LLLT is used in the treatment of OA combined with the variation in training and treatment protocols supports the need for further research regarding the application and efficacy of LLLT in dogs with OA.
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Alam, Mohammad Khursheed. "Laser-Assisted Orthodontic Tooth Movement in Saudi Population: A Prospective Clinical Intervention of Low-Level Laser Therapy in the 1st Week of Pain Perception in Four Treatment Modalities." Pain Research and Management 2019 (October 20, 2019): 1–11. http://dx.doi.org/10.1155/2019/6271835.
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Background. This first-in-human study in Saudi orthodontic patients has evaluated the role of low-level laser therapy (LLLT) in pain perception (PP). The outcome of single application of LLLT with 4 different treatment modalities (TM) on PP are evaluated following orthodontic bracket bonding on maxilla. Materials and Methods. A prospective clinical intervention with implementation of parallel technique in each group, 32 orthodontic patients with ectopic canine requiring fixed orthodontic appliance were enrolled and randomly allocated to the 4 groups: LLLT + self-ligating (SL) bracket, LLLT + conventional (Conv.) bracket, non-LLLT + SL bracket, and non-LLLT + Conv. bracket. Orthodontic bracket bonding from 1st molar to 1st molar and superelastic 0.012 inch NiTi were applied for the maxilla. For each patient, maxillary 1st molar to molar received a single application of LLLT using a 940 nm Ga-Al-As laser device on 5 different points labially/buccally and palatally. Main outcome measure was the degree of PP score during the 1st week of orthodontic tooth movement (OTM) after 4 hours, 24 hours, 3 days, and 7 days of both LLLT and non-LLLT treatment applications. A questionnaire with an 11-point numeric rating scale (NRS) was used for PP. Results. Mean ± SD of PP in the LLLT + SL group was 3.33 ± 1.4, 3.58 ± 1.06, 2.31 ± 0.67, and 1.89 ± 0.54 in 4 hours, 24 hours, 3 days, and 7 days, respectively. Compared to all 4 TM groups, LLLT groups showed better PP. More statistically significant differences were found in LLLT groups. No harms were encountered. Limitations. The intervention provider and the patient were not blinded to the intervention. Conclusion. The LLLT + SL group revealed significantly promising benefits on PP during OTM.
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Chen, Chia-Hsin, Chau-Zen Wang, Yan-Hsiung Wang, Wei-Ting Liao, Yi-Jen Chen, Chang-Hung Kuo, Hsuan-Fu Kuo, and Chih-Hsing Hung. "Effects of Low-Level Laser Therapy on M1-Related Cytokine Expression in Monocytes via Histone Modification." Mediators of Inflammation 2014 (2014): 1–13. http://dx.doi.org/10.1155/2014/625048.
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Low-level laser therapy (LLLT) has been used in the treatment of radiotherapy-induced oral mucositis and allergic rhinitis. However, the effects of LLLT on human monocyte polarization into M1 macrophages are unknown. To evaluate the effects of LLLT on M1-related cytokine and chemokine production and elucidate the mechanism, the human monocyte cell line THP-1 was treated with different doses of LLLT. The expression of M1-related cytokines and chemokines (CCL2, CXCL10, and TNF-α) was determined by ELISA and real-time PCR. LLLT-associated histone modifications were examined by chromatin immunoprecipitation (ChIP) assays. Mitochondrial involvement in the LLLT-induced M1-related cytokine expression was evaluated by quantitative real-time PCR. Flow cytometry was used to detect the cell surface markers for monocyte polarization. The results showed that LLLT (660 nm) significantly enhanced M1-related cytokine and chemokine expression in mRNA and protein levels. Mitochondrial copy number and mRNA levels of complex I-V protein were increased by LLLT (1 J/cm2). Activation of M1 polarization was concomitant with histone modification at TNF-αgene locus andIP-10gene promoter area. This study indicates that LLLT (660 nm) enhanced M1-related cytokine and chemokine expression via mitochondrial biogenesis and histone modification, which may be a potent immune-enhancing agent for the treatment of allergic diseases.
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Han, Der-Sheng, Cheng-Han Lee, Yih-Dar Shieh, and Chih-Cheng Chen. "Involvement of Substance P in the Analgesic Effect of Low-Level Laser Therapy in a Mouse Model of Chronic Widespread Muscle Pain." Pain Medicine 20, no. 10 (March 25, 2019): 1963–70. http://dx.doi.org/10.1093/pm/pnz056.
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Abstract Background Low-level laser therapy (LLLT) is widely used in pain control in the field of physical medicine and rehabilitation and is effective for fibromyalgia pain. However, its analgesic mechanism remains unknown. A possible mechanism for the effect of LLLT on fibromyalgia pain is via the antinociceptive signaling of substance P in muscle nociceptors, although the neuropeptide has been known as a neurotransmitter to facilitate pain signals in the spinal cord. Objective To establish an animal model of LLLT in chronic muscle pain and to determine the role of substance P in LLLT analgesia. Methods We employed the acid-induced chronic muscle pain model, a fibromyalgia model proposed and developed by Sluka et al., and determined the optimal LLLT dosage. Results LLLT with 685 nm at 8 J/cm2 was effective to reduce mechanical hyperalgesia in the chronic muscle pain model. The analgesic effect was abolished by pretreatment of NK1 receptor antagonist RP-67580. Likewise, LLLT showed no analgesic effect on Tac1-/- mice, in which the gene encoding substance P was deleted. Besides, pretreatment with the TRPV1 receptor antagonist capsazepine, but not the ASIC3 antagonist APETx2, blocked the LLLT analgesic effect. Conclusions LLLT analgesia is mediated by the antinociceptive signaling of intramuscular substance P and is associated with TRPV1 activation in a mouse model of fibromyalgia or chronic muscle pain. The study results could provide new insight regarding the effect of LLLT in other types of chronic pain.
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Choung, Lee, Ham, Lee, Kim, Pang, Jahng, and Lee. "Effectiveness of Low-Level Laser Therapy with a 915 Nm Wavelength Diode Laser on the Healing of Intraoral Mucosal Wound: An Animal Study and a Double-Blind Randomized Clinical Trial." Medicina 55, no. 8 (July 24, 2019): 405. http://dx.doi.org/10.3390/medicina55080405.
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Background and objectives: Diode laser has been the most popular low-level laser therapy (LLLT) technique in dentistry due to its good tissue penetration, lower financial costs, small size for portable application, and convenience to use. A series of recent studies with 940 nm or 980 nm lasers demonstrated that LLLT showed positive effects after third molar extraction or periodontal flap surgery. However, the effects of LLLT on intraoral mucosal wound healing after surgical incision have not yet been determined in human clinical study. Materials and Methods: The present study was performed to determine the efficacy and safety of 915 nm wavelength low-level laser therapy (LLLT) in mucosal wound healing. A total of 108 Sprague–Dawley rats were used. They were divided into three groups: Abrasive wound group, immediate LLLT once group, and daily LLLT group. As a clinical study, a total of 16 patients with split-mouth design subjected to bilateral mandibular third molar extraction were allocated into the LLLT group and placebo group. The process of LLLT was performed on postoperative days 0, 1, and 7, and parameters related to wound healing were analyzed on days 1, 7, and 14. Results: Repeated laser irradiation promoted mucosal wound healing of the rats. In the clinical study, although there were no significant statistical differences between the LLLT and placebo groups in all inflammatory parameters, the early stage mucosal healing tendency of wound dehiscence was higher in the LLLT group than in the placebo group clinically on postoperative day 1. Conclusions: The present results showed that 915 nm LLLT could be applied safely as an auxiliary therapy for mucosal wound healing.
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Xiong, Fen, Tian Mao, Hongfei Liao, Xiaoqin Hu, Lei Shang, Li Yu, Nana Lin, et al. "Orthokeratology and Low-Intensity Laser Therapy for Slowing the Progression of Myopia in Children." BioMed Research International 2021 (January 27, 2021): 1–10. http://dx.doi.org/10.1155/2021/8915867.
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Orthokeratology (OK) is widely used to slow the progression of myopia. Low-level laser therapy (LLLT) provides sufficient low energy to change the cellular function. This research is aimed at verifying the hypothesis that LLLT treatment could control myopia progression and comparing the abilities of OK lenses and LLLT to control the refractive error of myopia. Eighty-one children (81 eyes) who wore OK lenses, 74 children (74 eyes) who underwent LLLT treatment, and 74 children (74 eyes) who wore single-vision distance spectacles for 6 months were included. Changes in axial length (AL) were 0.23 ± 0.06 mm for children wearing spectacles, 0.06 ± 0.15 mm for children wearing OK lens, and − 0.06 ± 0.15 mm for children treated with LLLT for 6 months. Changes in subfoveal choroidal thickness (SFChT) observed at the 6-month examination were − 16.84 ± 7.85 μ m , 14.98 ± 22.50 μ m , and 35.30 ± 31.75 μ m for the control group, OK group, and LLLT group, respectively. Increases in AL at 1 month and 6 months were significantly associated with age at LLLT treatment. Changes in AL were significantly correlated with the baseline spherical equivalent refraction (SER) and baseline AL in the OK and LLLT groups. Increases in SFChT at 1 month and 6 months were positively associated with age at enrolment for children wearing OK lens. At 6 months, axial elongation had decelerated in OK lens-wearers and LLLT-treated children. Slightly better myopia control was observed with LLLT treatment than with overnight OK lens-wearing. Evaluations of age, SER, and AL can enhance screening for high-risk myopia, improve the myopia prognosis, and help determine suitable control methods yielding the most benefits.
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Zhang, Lu-yao, Heng Li, Yan-wei Wu, Lei Cheng, Yu-xi Yan, Xiao-qian Yang, Feng-hua Zhu, Shi-jun He, Wei Tang, and Jian-ping Zuo. "(5R)-5-hydroxytriptolide ameliorates lupus nephritis in MRL/lpr mice by preventing infiltration of immune cells." American Journal of Physiology-Renal Physiology 312, no. 4 (April 1, 2017): F769—F777. http://dx.doi.org/10.1152/ajprenal.00649.2016.
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(5R)-5-hydroxytriptolide (LLDT-8), a triptolide derivative with low toxicity, was previously reported to have strong immunosuppressive effects both in vitro and in vivo, but it remains unknown whether LLDT-8 has a therapy effect on systemic lupus erythematosus. In this study, we aimed to investigate the therapeutic effects of LLDT-8 on lupus nephritis in MRL/ lpr mice, a model of systemic lupus erythematosus. Compared with the vehicle group, different clinical parameters were improved upon LLDT-8 treatment as follows: prolonged life span of mice, decreased proteinuria, downregulated blood urea nitrogen and serum creatinine, reduced glomerular IgG deposits, and ameliorated histopathology. A decreased expression of the inflammatory cytokines IFN-γ, IL-17, IL-6, and TNF-α was also observed in the kidney of LLDT-8 treated MRL/ lpr mice. Moreover, infiltration of T cells in the kidney was mitigated after LLDT-8 treatment, corresponding with decreased expression of related chemokines IP-10, Mig, and RANTES in the kidney. The proportion of macrophage and neutrophil cells and related chemokines expression was also reduced in kidneys of LLDT-8-treated mice. In the human proximal tubule epithelial cell line and mouse mesangial cell line, consistent with our in vivo experimental results, LLDT-8 suppressed the expression of related chemokines and IL-6. In summary, LLDT-8 has a therapeutic benefit for lupus nephritis via suppressing chemokine expression and inhibiting immune cell infiltration in kidneys of MRL/ lpr mice.
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Inada, Ryoji, Kohei Okuno, Shunsuke Kito, Tomohiro Tojo, and Yoji Sakurai. "Properties of Lithium Trivanadate Film Electrodes Formed on Garnet-Type Oxide Solid Electrolyte by Aerosol Deposition." Materials 11, no. 9 (September 1, 2018): 1570. http://dx.doi.org/10.3390/ma11091570.
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We fabricated lithium trivanadate LiV3O8 (LVO) film electrodes for the first time on a garnet-type Ta-doped Li7La3Zr2O12 (LLZT) solid electrolyte using the aerosol deposition (AD) method. Ball-milled LVO powder with sizes in the range of 0.5–2 µm was used as a raw material for LVO film fabrication via impact consolidation at room temperature. LVO film (thickness = 5 µm) formed by AD has a dense structure composed of deformed and fractured LVO particles and pores were not observed at the LVO/LLZT interface. For electrochemical characterization of LVO film electrodes, lithium (Li) metal foil was attached on the other end face of a LLZT pellet to comprise a LVO/LLZT/Li all-solid-state cell. From impedance measurements, the charge transfer resistance at the LVO/LLZT interface is estimated to be around 103 Ω cm2 at room temperature, which is much higher than at the Li/LLZT interface. Reversible charge and discharge reactions in the LVO/LLZT/Li cell were demonstrated and the specific capacities were 100 and 290 mAh g−1 at 50 and 100 °C. Good cycling stability of electrode reaction indicates strong adhesion between the LVO film electrode formed via impact consolidation and LLZT.
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Lubart, R., and H. Friedmann. "LLLT AND PDT." LASER THERAPY 20, no. 3 (2011): 233. http://dx.doi.org/10.5978/islsm.20.233.
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McKibbin, Lnoyd S., and Robert Downie. "LLLT IN CANADA." LASER THERAPY 3, no. 1 (1991): 45–47. http://dx.doi.org/10.5978/islsm.91-nu-01.
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ZU, FANG-QIU, XUN YI, XIAN-FEN LI, ZHI-HAO CHENG, BING ZHOU, and YI-PING CHENG. "OBSERVATION OF A REVERSIBLE LIQUID–LIQUID STRUCTURAL CHANGE IN Pb–Sn MELTS WITH ELECTRICAL RESISTIVITY METHOD." International Journal of Modern Physics B 22, no. 21 (August 20, 2008): 3683–93. http://dx.doi.org/10.1142/s0217979208039940.
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In recent years, a number of studies with different methods dedicated to structures and properties of liquid alloys revealed the occurrence of temperature-induced liquid–liquid structural transformation (TI-LLST). As yet, however, few investigations have concerned the reversibility of TI-LLST. The present paper reports a reversible TI-LLST in Pb – Sn alloys, which was observed with the electrical resistivity method during succeeding cooling and heating runs after the first heating process. The reversible TI-LLST is not the same as the TI-LLST in the first heating run, because the temperature ranges and the patterns are different from those of the latter. It is interesting that the similar phenomenon is also observed in pure tin, which suggests that the reversible TI-LLST in liquid Pb – Sn alloy is related to that in liquid Sn .
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Anbulakshmi, C., P. Selvarajan, and S. Selvaraj. "Growth, XRD, Mechanical, Optical and SHG Studies of L-Lysine L-Tartaric Acid Crystals." Asian Journal of Engineering and Applied Technology 8, no. 2 (May 5, 2019): 57–62. http://dx.doi.org/10.51983/ajeat-2019.8.2.1137.
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Single crystals of L-lysine L-tartaric acid (LLLT) were grown by solution method using double distilled water as the solvent. The grown crystals LLLT were subjected to characterization studies like XRD studies, mechanical studies, optical studies and SHG studies. From XRD studies, it is ascertained that LLLT crystal crystallizes in monoclinic structure. The grown crystal has high transmittance in the visible region and it has high optical band gap. The mechanical parameters like hardness, work hardening coefficient, yield strength, stiffness constant, brittleness index, corrected hardness and resistance pressure of LLLT crystal have been evaluated by using Vickers microhardness method. The relative SHG efficiency of LLLT crystal has been determined by Kurtz-Perry powder technique.
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Park, In-Su, Phil-Sang Chung, and Jin Chul Ahn. "Angiogenic Synergistic Effect of Adipose-Derived Stromal Cell Spheroids with Low-Level Light Therapy in a Model of Acute Skin Flap Ischemia." Cells Tissues Organs 202, no. 5-6 (2016): 307–18. http://dx.doi.org/10.1159/000445710.
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Human adipose-derived mesenchymal stem cells (hASCs) are an attractive cell source for tissue engineering. However, one obstacle to this approach is that the transplanted hASC population can decline rapidly in the recipient tissue. The aim of this study was to investigate the effects of low-level light therapy (LLLT) on transplanted spheroid hASCs in skin flaps of mice. hASCs were cultured in monolayers or spheroids. LLLT, hASCs, spheroids and spheroids transplanted with LLLT were applied to the skin flaps. Healing of the skin flaps was assessed by gross evaluation and by hematoxylin and eosin staining and elastin van Gieson staining. Compared with the spheroid group, skin flap healing was enhanced in the spheroid + LLLT group, including the neovascularization and regeneration of skin appendages. The survival of hASCs was enhanced by decreased apoptosis of hASCs in the skin flaps of the spheroid + LLLT group. The secretion of growth factors was stimulated in the spheroid + LLLT group compared with the ASC and spheroid groups. These data suggest that LLLT was an effective biostimulator of spheroid hASCs in the skin flaps, enhancing the survival of hASCs and stimulating the secretion of growth factors.
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Patterson, Stephen D., and Richard A. Ferguson. "Enhancing Strength and Postocclusive Calf Blood Flow in Older People With Training With Blood-Flow Restriction." Journal of Aging and Physical Activity 19, no. 3 (July 2011): 201–13. http://dx.doi.org/10.1123/japa.19.3.201.
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The response of calf-muscle strength, resting blood flow, and postocclusive blood flow (PObf) were investigated after 4 wk of low-load resistance training (LLRT) with and without blood-flow restriction in a matched-leg design. Ten untrained older individuals age 62–73 yr performed unilateral plantar-flexion LLRT at 25% 1-repetition maximum (1RM). One limb was trained with normal blood flow and the other had blood flow restricted using a pressure cuff above the knee. 1RM, isometric maximal voluntary contraction, and isokinetic strength at 0.52 rad/s increased (p < .05) more after LLRT with blood-flow restriction than with normal blood flow. Peak PObf increased (p < .05) after LLRT with blood-flow restriction, compared with no change after LLRT with normal blood flow. These results suggest that 4 wk of LLRT with blood-flow restriction may be beneficial to older individuals to improve strength and blood-flow parameters.
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Gorchak, Yu Yu, M. L. Stakhanov, G. P. Gens, K. A. Firsov, D. N. Reshetov, S. M. Gainedinov, A. A. Kurnosov, A. Yu Korobkova, and L. I. Korobkova. "LOW-INTENSITY LASER RADIATION IN CORRECTION OF BLOOD HEMODYNAMIC AND RHEOLOGICAL PARAMETERS AFTER SURGERY FOR HEAD AND NECK CANCER." Siberian journal of oncology 19, no. 5 (October 29, 2020): 28–34. http://dx.doi.org/10.21294/1814-4861-2020-19-5-28-34.
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Purpose: to study the effect of low-level laser therapy (LLLT) in correction of blood hemodynamic and rheological parameters after surgery for head and neck cancer.Material and Methods. The study included 134 head and neck cancer patients with a median age of 54.24 ± 12.7 years (range: 23–78 years). There were 39 (29.1 %) men and 95 (70.9 %) women. To assess the effectiveness of LLLT, all patients were divided into 3 groups. Group I included 45 patients, who received conventional therapy without the use of LLLT. Group II consisted of 45 patients, who received conventional therapy in combination with LLLT. Group III included 44 patients, who received LLLT alone. Azor 2K-02 was used as a source of LLLT in the red to near infrared spectral range. Characteristics of blood flow in the vessels of the neck and the rheological properties of blood, as well as the parameters of spontaneous platelet aggregation and the content of soluble fibrinmonomer complexes in the blood plasma of patients were studied.Results. The data obtained indicated that the use of LLLT promoted normalization of blood rheological properties in patients, who underwent surgery. Normalization of blood rheological properties occurred faster and lasted for a longer period. In patients, who received conventional therapy in combination with LLLT, the hemodynamic and rheological parameters of blood were improved 2–14 days after therapy, whereas in patients receiving conventional therapy alone, this improvement was seen 30 or more days after therapy.Conclusion. LLLT in combination with conventional therapy was shown to have a positive effect on hemodynamic and rheological parameters after surgery for head and neck cancer.
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Seo, U.-Hyeok, Jung-Hee Kim, and Byoung-Hee Lee. "Effects of Mulligan Mobilization and Low-Level Laser Therapy on Physical Disability, Pain, and Range of Motion in Patients with Chronic Low Back Pain: A Pilot Randomized Controlled Trial." Healthcare 8, no. 3 (July 29, 2020): 237. http://dx.doi.org/10.3390/healthcare8030237.
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This study aimed to determine the combined treatment effects of Mulligan sustained natural apophyseal glides (SNAGs) and low-level laser therapy (LLLT) on function, pain, and range of motion (ROM) in patients with chronic low back pain. A total of 49 adults participated in this study and were randomly divided into three groups (SNAGs with LLLT group, SNAGs group, and control group). The participants in the SNAGs with LLLT group received SNAGs for 10 min, LLLT for 10 min, and electrotherapy for 10 min. The SNAGs group received SNAGs for 10 min and electrotherapy for 20 min. The control group received electrotherapy for 30 min. All participants received the assigned treatment for 30 min a day, 3 times a week, for 4 weeks. We used the visual analogue scale (VAS) to measure pain, the modified-modified Schober test (MMST) to measure ROM, and the Roland Morris disability questionnaire (RMDQ) to measure physical disability. Compared to the pre-intervention values, the VAS and MMST scores significantly increased after the intervention in the SNAGs with LLLT group (p = 0.000) and the SNAGs group (p = 0.000). The RMDQ score significantly improved in the SNAGs with LLLT (p = 0.000), SNAGs (p = 0.000) and control (p = 0.025) group after the intervention. The inter-group differences were greater for the SNAGs with LLLT and SNAGs groups than for the control group (p = 0.001), and the difference was greater for the SNAGs with LLLT than for the SNAGs (p = 0.001) with respect to the VAS, MMST, and RMDQ scores. These results indicate that significant improvement in pain, function, and ROM may be achieved by a combination of SNAGs and LLLT to treat chronic low back pain.
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Hanna, Kamil, James Palmer, Lourdes Castanon, Muhammad Zeeshan, Mohammad Hamidi, Narong Kulvatunyou, Lynn Gries, and Bellal Joseph. "Racial and Ethnic Differences in Limiting Life-Sustaining Treatment in Trauma Patients." American Journal of Hospice and Palliative Medicine® 36, no. 11 (May 5, 2019): 974–79. http://dx.doi.org/10.1177/1049909119847970.
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Introduction: Differences in health care between racial and ethnic groups exist. The literature suggests that African Americans and Hispanics prefer more aggressive treatment at the end of life. The aim of this study is to assess racial and ethnic differences in limiting life-sustaining treatment (LLST) after trauma. Study Design: We performed a 2-year (2013-2014) retrospective analysis of Trauma Quality Improvement Program database. Patients with age ≥16 and Injury Severity Score (ISS) ≥ 16 were included. Outcome measures were the incidence and the predictors of LLST. Multivariable logistic regression was performed to control for confounding variables. Results: A total of 97 024 patients were identified. Mean age was 49 (21) years, 68% were male, 68% were white, and 14% were Hispanic. The overall incidence of LLST was 7.2%. Based on race, LLST was selected as consistent with goals of care more often in white when compared to African American individuals who experience serious traumatic injury (8.0% vs 4.5%; P < .001). Based on ethnicity, LLST was more often selected in non-Hispanics (7.5% vs 5.2%, P < .001) when compared to Hispanics. On regression analysis, the independent predictors of LLST were white race (odds ratio [OR]: 2.7 [1.6–4.4], P = .02), non-Hispanic ethnicity (OR: 1.9 [1.4-4.6]; P = .03), severe head injury (OR: 1.7 [1.1-3.2]; P = .04), and ISS (OR: 3.1 [2.4-5.1]; P < .01). Conclusions: Differences exist in selecting LLST between different racial and ethnic groups in severe trauma. African Americans and Hispanics are less likely to select LLST when compared to whites and non-Hispanics. Further studies are required to analyze the factors associated with selecting LLST in African Americans and Hispanics.
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McMullan, Patrick J., Jakob Krzyston, and Robert Osgood. "Bactericidal Effects of Low-Irradiance Low Level Light Therapy on Methicillin-Resistant Staphylococcus Aureus in Vitro." Fine Focus 2, no. 2 (August 1, 2016): 104–15. http://dx.doi.org/10.33043/ff.2.2.104-115.
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Low Level Light Therapy (LLLT) within the visible blue spectrum (400-470 nanometers) is a well-documented therapeutic alternative to combat multidrug resistant organism infections through the generation of reactive oxygen species (ROS). However, one shortcoming of LLLT is that many studies deliver therapy through high powered lasers and lamps. High powered light sources not only require specialized staff to operate, but they also deliver the total light dose (fluence) at an exceptionally high intensity, or irradiance, which could consequently deplete the oxygen supplies required to promote LLLT’s bactericidal properties. To overcome these faults, low-irradiance LLLT, or delivering the same total fluence of LLLT over an extended period of time with decreased irradiance was evaluated in vitro. To further explore this alternative approach, the bactericidal effects of low-irradiance (10.44 mW/cm2) LLLT using wavelengths of 405-nm, 422-nm and 470-nm were studied on methicillin-resistant Staphylococcus aureus (MRSA) cultures. Among these wavelengths, it was determined that 405-nm LLLT provided the most effective reduction of bacterial load at the lowest total fluence (75 J/cm2) (94.50% reduction). The bactericidal effects of 405-nm low-irradiance LLLT were then further studied by treating MRSA cultures to 75 J/cm2 LLLT while using irradiances of 5.22 mW/cm2 and 3.48 mW/cm2. It was concluded that there was a greater reduction of MRSA bacterial load when samples were exposed to irradiances of 5.22 mW/cm2 (95.71% reduction) and 3.48 mW/cm2 (99.63% reduction). This study validates the bactericidal properties of low-irradiance LLLT on MRSA, and subsequent studies should be completed to optimize its full therapeutic potential.
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Ku Ishak, Ku Esyra Hani, and Mohammed Abdalla Ayoub. "Performance of liquid–liquid hydrocyclone (LLHC) for treating produced water from surfactant flooding produced water." World Journal of Engineering 17, no. 2 (December 2, 2019): 215–22. http://dx.doi.org/10.1108/wje-01-2019-0003.
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Purpose The purpose of this study is to investigate the performance of the fabricated liquid–liquid hydrocyclone (LLHC) with dimensions similar to those of one of the Malaysian oilfields with the presence of an anionic surfactant, S672. The effect of salinity and initial oil concentration were also investigated following the actual range concentration. Design/methodology/approach The current control system’s pressure drop ratio (PDR) does not necessarily lead to an efficient LLHC. Therefore, rather than using the PDR, the efficiency of the LLHC was analyzed by comparing the concentration of oil in the effluents with the concentration of oil at the feed of the LLHC. An LLHC test rig was developed at Centre of Enhanced Oil Recovery, Universiti Teknologi PETRONAS. Emulsions were prepared by mixing the brines, S672 and oil by using Ultra Turrax ultrasonic mixer. The emulsion was pumped into the LLHC at different feed flowrate and split ratio. The brines concentration, initial oil concentration and S672 concentration were also varied in this study. Samples were taken at the underflow of the LLHC and the oil in water concentration analysis was done for the samples using TD-500D equipment. Findings It was found that the efficiency of oil removal decreased with an increase in S672 concentration but increased with the increase in salinity and initial oil concentration. Originality/value The optimum feed flowrate for the LLHC of 45 mm diameter and length of 1,125 mm with the presence of S672 surfactant was found to be 40 L/min with a split ratio of 14%. This study can be used as a guidance for future optimization of the LLHC in the presence of the surfactant.
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Antunes, H. S., D. Herchenhorn, C. M. Araujo, E. Cabral, E. M. d. S. Ferreira, I. A. Small, M. P. Rampini, et al. "Phase III trial of low-level laser therapy to prevent induced oral mucositis in head and neck cancer patients submitted to concurrent chemoradiation." Journal of Clinical Oncology 29, no. 18_suppl (June 20, 2011): LBA5524. http://dx.doi.org/10.1200/jco.2011.29.18_suppl.lba5524.
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LBA5524 Background: Oral mucositis (OM) remains a limiting factor in in head and neck squamous cell carcinomas (HNSCC) patients (pts) treated with chemoradiation (CRT) leading to pain, dysphagia, and weight loss. Low-level laser therapy (LLLT) emerges as a promising, preventive therapy of CRT-induced OM. Yet, a definitive randomized trial supporting its use is lacking. This study was designed to assess the efficacy of LLLT in reducing the incidence and/or severity of OM. Methods: Assuming OM grade (G3) for placebo 0.4 (P0); LLLT 0.15 (P1) ; β=0.2; α=0.05, sample size was 94 pts. From Jun 2007 to Dec 2010, 47 LLLT and 47 placebo pts bearer of HNSCC of nasopharynx, oropharynx and hipopharynx entered a prospective, randomized, double blind, placebo-controlled, phase III trial. CRT consisted of conventional RT 70.2 Gy (1.8Gy/d, 5 times/wk) + concurrent cisplatin 100 mg/m2 every 3 wks. Main endpoints were OM incidence and severity, RT interruptions due to OM and pain intensity. The LLLT used daily was a diode InGaAlP (660nm-100mW-4J/cm²). OM evaluation was done by WHO and OMAS scale. Results: Mean age was 54.6 and 87.2% of pts were male. Primary site: oropharynx (74 pts), nasopharynx (9 pts), hypopharynx (11 pts). In the LLLT arm the incidence of OM G 3/4 was only 6.4% versus 48% in the placebo arm; HR of 0.13 (IC 95%, p<0.001). Besides in the LLLT arm 51% of pts did not have ulcers versus 17% in placebo arm (p<0.001). LLLT pts had less severe pain (p=0.012), used less narcotic analgesic, HR 0.33 (IC 95%, p<0.001) and required less gastrostomia, HR 0.037 (IC 95%, p= 0.005). No LLLT pts had RT interrupted due to OM. EORTC QLQ-C30 and its specific head and neck module QLQ-H&N35 were applied. Results clearly favored the LLLT arm. In QLQ-C30 benefit was seen in both physical and emotional functioning (p=0.037), fatigue (p=0.011), pain (p=0.043); and in QLQ-H&N35, pain (p=0.007), swallowing (p=0.001) and trouble with social eating (p=0.026). Conclusions: Our results indicate that upfront LLLT in HNSCC pts submitted to CRT is an effective tool in reducing G 3/4 OM, oral pain, use of narcotic and gastrostomia. QoL data supports the efficacy findings. Thereby LLLT should be the new standard of care in this setting.
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da Cunha Moraes, Gabriel, Luana Beatriz Vitoretti, Auriléia Aparecida de Brito, Cintia Estefano Alves, Nicole Cristine Rigonato de Oliveira, Alana dos Santos Dias, Yves Silva Teles Matos, et al. "Low-Level Laser Therapy Reduces Lung Inflammation in an Experimental Model of Chronic Obstructive Pulmonary Disease Involving P2X7 Receptor." Oxidative Medicine and Cellular Longevity 2018 (2018): 1–8. http://dx.doi.org/10.1155/2018/6798238.
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Chronic obstructive pulmonary disease (COPD) is a progressive disease characterized by irreversible airflow limitation, airway inflammation and remodeling, and enlargement of alveolar spaces. COPD is in the top five leading causes of deaths worldwide and presents a high economic cost. However, there are some preventive measures to lower the risk of developing COPD. Low-level laser therapy (LLLT) is a new effective therapy, with very low cost and no side effects. So, our objective was to investigate if LLLT reduces pulmonary alterations in an experimental model of COPD. C57BL/6 mice were submitted to cigarette smoke for 75 days (2x/day). After 60 days to smoke exposure, the treated group was submitted to LLLT (diode laser, 660 nm, 30 mW, and 3 J/cm2) for 15 days and euthanized for morphologic and functional analysis of the lungs. Our results showed that LLLT significantly reduced the number of inflammatory cells and the proinflammatory cytokine secretion such as IL-1β, IL-6, and TNF-α in bronchoalveolar lavage fluid (BALF). We also observed that LLLT decreased collagen deposition as well as the expression of purinergic P2X7 receptor. On the other hand, LLLT increased the IL-10 release. Thus, LLLT can be pointed as a promising therapeutic approach for lung inflammatory diseases as COPD.
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Doyle, Andrew T., Christine Lauber, and Kendra Sabine. "The Effects of Low-Level Laser Therapy on Pain Associated With Tendinopathy: A Critically Appraised Topic." Journal of Sport Rehabilitation 25, no. 1 (February 2016): 83–90. http://dx.doi.org/10.1123/jsr.2014-0219.
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Clinical Scenario:Tendinopathies plague many active individuals, causing pain and reducing sport activity by decreasing range of motion and strength. There are many modalities that have been used to treat pain associated with chronic inflammation, such as ultrasound, moist heat packs, and electrical stimulation. Low-level laser therapy (LLLT) is one such modality. Potential benefits of managing pain associated with tendinopathies have been investigated using LLLT. Cellular respiration and metabolism are thought to be increased by LLLT acting on the mitochondrial cytochromes. The effects LLLT may have on cellular activity could increase blood flow to progress the healing process by reducing the pain-spasm cycle. The purpose of this critically appraised topic is to identify the clinical effectiveness of LLLT on pain associated with tendinopathy and to identify the parameters used to achieve statistically and clinically relevant pain outcomes.Focused Clinical Question:What is the effect of LLLT on pain associated with tendinopathy?Clinical Bottom Line:Although LLLT significantly decreases pain from baseline, its use may be no better than placebo or traditional treatments such as ultrasound, moist heat packs, electrical stimulation, or therapeutic exercise to reduce pain associated with tendinopathy. Total accumulated joules across the treatment sessions may need to be taken into account as a parameter.
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Paramonova, Ekaterina, Ed D. de Jong, Bastiaan P. Krom, Henny C. van der Mei, Henk J. Busscher, and Prashant K. Sharma. "Low-Load Compression Testing: a Novel Way of Measuring Biofilm Thickness." Applied and Environmental Microbiology 73, no. 21 (August 31, 2007): 7023–28. http://dx.doi.org/10.1128/aem.00935-07.
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ABSTRACT Biofilms are complex and dynamic communities of microorganisms that are studied in many fields due to their abundance and economic impact. Biofilm thickness is an important parameter in biofilm characterization. Current methods of measuring biofilm thicknesses have several limitations, including application, availability, and costs. Here, we present low-load compression testing (LLCT) as a new method for measuring biofilm thickness. With LLCT, biofilm thicknesses are measured during compression by inducing small loads, up to 5 Pa, corresponding to 0.1% deformation, making LLCT essentially a nondestructive technique. Comparison of the thicknesses of various bacterial and yeasts biofilms obtained by LLCT and by using confocal laser scanning microscopy (CLSM) resulted in the conclusion that CLSM underestimates the biofilm thickness due to poor penetration of different fluorescent dyes, especially through the thicker biofilms, whereas LLCT does not suffer from this thickness limitation.
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Cinar, Eda, Shikha Saxena, and Fatma Uygur. "Combination Therapy Versus Exercise and Orthotic Support in the Management of Pain in Plantar Fasciitis: A Randomized Controlled Trial." Foot & Ankle International 39, no. 4 (January 12, 2018): 406–14. http://dx.doi.org/10.1177/1071100717747590.
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Background: This study aimed at estimating the effectiveness of two commonly used modalities—extracorporeal shock wave therapy (ESWT) and low-level laser therapy (LLLT)—each combined with usual care (exercises and orthotic supports) in comparison to only usual care to relieve pain in patients with plantar fasciitis (PF). Methods: Participants with PF were randomly allocated into 3 groups: ESWT (n = 25), LLLT (n = 24), and control (n = 17). All participants received a home exercise program with orthotic support. The ESWT group received 2000 shock waves with 0.02 mJ/mm2 for 3 sessions, once a week; LLLT group received gallium-aluminum-arsenide laser with 850 nm wavelength for 10 sessions, 3 times a week. Pain was measured by Foot Function Index-pain subscale (FFI-p) and Numerical Rating Scale for pain (NRS-p). The scores were recorded at baseline, third week, and third month after the treatment. Analysis was performed using repeated measures ANOVA. Results: There was a significant improvement in pain over the 3 months in all groups on both FFI-p ( P < .001) and NRS-p ( P < .001). In NRS-p, LLLT group had significantly lower pain than ESWT ( P = .002) at the third week and control ( P = .043) and ESWT ( P = .003) at third month. In FFI-p total score, ESWT group had higher pain than LLLT ( P = .003) and control ( P = .035) groups at third week and LLLT ( P = .010) group at third month. Conclusion: When LLLT and ESWT were combined with usual care, LLLT was found to be more effective than ESWT in reducing pain in PF at short-term follow-up. Level of Evidence: Level II, comparative study.
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Tabatabaei Mirakabad, Fatemeh Sadat, Maryam Sadat Khoramgah, Foozhan Tahmasebinia, Shahram Darabi, Saeed Abdi, Hojjat Allah Abbaszadeh, and Shahrokh Khoshsirat. "The Effect of Low-Level Laser Therapy and Curcumin on the Expression of LC3, ATG10 and BAX/BCL2 Ratio in PC12 Cells Induced by 6-Hydroxide Dopamine." Journal of Lasers in Medical Sciences 11, no. 3 (June 21, 2020): 299–304. http://dx.doi.org/10.34172/jlms.2020.50.
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Introduction: Parkinson’s disease (PD) is one of the most common neurodegenerative disorders. The neuroinflammation in the brain of PD patients is one of the critical processes in the immune pathogenesis of PD leading to the neural loss in the substantia nigra. Due to the anti-inflammatory effects of curcumin (CU) and low-level laser therapy (LLLT), we examined the protective effect of CU and LLLT on PC12 cells treated with 6-hydroxydopamine (6-OHDA) as a Parkinson model. Methods: PC12 cells were pretreated using various concentrations of 6-OHDA for 24 hours to induce oxidative and cellular damages. PC12-6-OHDA cells were co-treated with CU and LLLT. The effects of CU and LLLT on Bax/Bcl2 and LC3/ATG10 expression were analyzed by real-time PCR and cell viability was assessed by MTT assay. Cell A Software was used to calculate the length of the Neurite and cell body areas. Results: The results of this study show that the combination of CU dose-dependently and LLLT has a significant neuroprotective effect on cells and cellular death significantly decreases by increasing CU concentration. CU+LLLT decreases Bax/Bcl2 ratio which is an indicator of apoptosis and it also rescued a decrease in LC3 and ATG10 expression in comparison with 6-OHDA group. Conclusion: This study shows that the combination of 5 μM CU and LLLT has the best neuroprotective effect on PC12 cells against 6-OHDA by decreasing the BAX/BCL2 ratio.
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Song, Jae-Min, Bong-Soo Park, Sang-Hun Shin, and In-Ryoung Kim. "Low-Level Laser Irradiation Stimulates RANKL-Induced Osteoclastogenesis via the MAPK Pathway in RAW 264.7 Cells." Applied Sciences 11, no. 12 (June 9, 2021): 5360. http://dx.doi.org/10.3390/app11125360.
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Low-level laser therapy (LLLT) is recognized as an effective medical tool for the treatment of various conditions requiring tissue repair, pain relief, inflammation treatment, and restoration of tissue dysfunction, and its development and research are growing rapidly. However, studies that analyze molecular biology by applying LLLT to osteoclasts are still insufficient to understand the mechanism. In order for LLLT to be suggested as an appropriate treatment method for the treatment of various bone diseases, it is necessary to elucidate the effect and mechanism of LLLT on osteoclast differentiation. In this study, we investigated the effect of LLLT on osteoclast differentiation using murine macrophage (RAW 264.7) cells by means of a Ga-As-Al laser (λ = 810, 80 mW). Our results indicate that LLLT did not induce cytotoxicity in RAW 264.7 cells. When LLLT was applied for 15 s to osteoclasts exposed to RANKL, the expression of NF-κB, ERK, p38, and c-Fos, which are associated with expression of NFATc1, was increased. The RT-PCR results also demonstrated significantly increased expression of osteoclast-specific genes, including NFATc1, TRAP, the calcitonin receptor, and cathepsin K, compared with the control. Taken together, we concluded that low-level laser irradiation induces osteoclastogenesis by enhancing the expression of NF-κB, MAPKs (ERK, p38), c-Fos, and NFATc1 in RAW 264.7 cells. These findings indicate that low-level laser irradiation could be considered a potential treatment option in various metabolic bone diseases that require osteoclastic activity and bone formation.
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Purwitasari Darmaputri, Nury Nusdwinuringtya, Nyoman Murdana, Tri Juli Edi Tarigan, and Dewi Friska. "Comparison Low-Level Laser Therapy (LLLT) of 10J/cm2 and 5 J/cm2 Energy Density for Healing Diabetes Foot Ulcer." Journal Of The Indonesian Medical Association 70, no. 2 (March 14, 2020): 16–22. http://dx.doi.org/10.47830/jinma-vol.70.2-2020-173.
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Background: Diabetic foot ulcer is a problem in patients with diabetes mellitus (DM). One adjuvant therapy that can enhance wound healing is Low-Level Laser Therapy (LLLT), but there is no established guideline regarding the dosage. In Indonesia, there has been no study comparing the energy density of LLLT on diabetic ulcer healingMethods: This is an experimental study on 28 subjects with a randomized diabetic foot ulcer. Group A received standard treatment of ulcer and LLLT 5J/cm2. Group B received standard treatment of ulcer and LLLT 10J/cm2.Results: The difference in wound size between group A and group B were 4.15 mm2 and 7.5 mm2 (p=0.178). The healing rate of group A and group B were 4.15 (-10-34.5) mm2/4 weeks and 7.5 (-2.8-34) mm2/4weeks (p=0.168). Conclusions: There was no statistically significant difference between the group receiving LLLT 5J/cm2 or 10 J/cm2 in diabetic foot ulcer healing.
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Casillas Santana, Miguel Angel Angel, María Fernanda García Vega, Juan Eduardo Gomez Vázquez, Olin Guadalupe Montero Jiménez, Daniela Orozco Jiménez, and Jair Rodríguez Zarate. "Clinical and experimental knowledge of photobiomodulation in accelerated orthodontics: a review." Revista Estomatología 28, no. 1 (December 1, 2020): 18–25. http://dx.doi.org/10.25100/re.v28i1.10548.
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In recent years, there has been an increasing interest in finding a noninvasive method to induce the acceleration of dental movement, methods such as low intensity vibrations, pulsed electromagnetic fields, and low-level laser therapy (LLLT). There have been multiple studies on the efficacy of LLLT in animal models, in vitro and in patients without conclusive results. Objective: Evaluate the state of the art on the use of LLLT to increase the rate of the orthodontic tooth movement to create a concise reference guide of the different laser and protocols available. Materials and Methods: We searched online databases for articles with the keywords LLLT, LLLI, OTM, photobiomodulation. Results: We found conflicting information as to the efficacy of LLLT to accelerate OTM. There is no consensus in the way the irradiation should be performed. Conclusions: The lack of a standardized irradiation protocol makes it hard to compare conflicting results, even in cases where the laser have the same technical specifications.
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Simon, Camila, Cássio Brendon dos Santos, Carla Albuquerque, Lucas Guilherme Hoffmann, Fernando Amâncio Aragão, and Gladson Ricardo Flor Bertolini. "Short-term comparison of the 660 and 830 nm laser in the treatment of temporomandibular dysfunction – a randomized clinical trial." European Journal of Clinical and Experimental Medicine 18, no. 4 (2021): 263–67. http://dx.doi.org/10.15584/ejcem.2020.4.1.
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Introduction. The objective of this study was to compare the effects of low-level laser therapy (LLLT), 660nm laser with 830nm, in temporomandibular dysfunction (TMD). Aim. To compare the effect of LLLT 660 nm and 830 nm in treatment of TMD. Material and methods. This is a randomized clinical study, composed of 30 volunteers with TMDs selected and divided into three groups: LLLT 660nm, LLLT 830nm and Sham. After the intervention, the results were reevaluated with the Fonseca anamnestic questionnaire (FAQ), American Academy of Orofacial Pain Questionnaire (AAOPQ), McGill Pain Questionnaire and Visual Analog Scale. Results. Analysis of the results showed that, although all groups had reduced values in the FAQ, only the laser groups presented alterations in the level of classification; for AAOPQ, only the treatment groups had a reduction in the positive responses, variables, the reduction was similar for all groups. Conclusion. LLLT produced a reduction in severity of symptoms but was like the sham for pain.
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Kholvadia, A., D. Constantinou, and P. Gradidge. "Exploring the efficacy of low-level laser therapy and exercise for knee osteoarthritis." South African Journal of Sports Medicine 31, no. 1 (August 12, 2019): 1–5. http://dx.doi.org/10.17159/2078-516x/2019/v31i1a6058.
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Background: Knee Osteoarthritis (KOA) is a prevalent, chronic disorder with excessive functional, social and economic burdens. The goal of treatment is to alleviate the symptoms and slow the progression. Documenting the effects of exercise and LLLT as co-modalities in the management of KOA allows practitioners to implement this management tool as part of KOA rehabilitation, resulting in the earlier discharge from a supervised rehabilitation setting.
Objective: The purpose of this study was to determine the effect of low-level laser therapy (LLLT) in the treatment of knee osteoarthritis (KOA). A randomised controlled trial (RCT) was conducted on 111 participants (aged between 40-75 years) diagnosed with KOA. Participants were randomised into an exercise (n=39), LLLT (n=40), or a combined exercise-LLLT (n=32) group.
Methods: The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scale was used to assess pain and functionality. Knee range of motion was assessed using a goniometer, and the one-minute timed sit–to-stand test measured physical functionality at four time points: (T1) baseline, (T2) post 12-session intervention, (T3) one-month post intervention and (T4) three-month’s post intervention. Knee circumference was measured using a measuring tape.
Results: WOMAC pain and functionality scale and knee circumference scores decreased in all three groups (P<0.05), but the combined exercise-LLLT group demonstrated better outcomes than the LLLT or exercise alone groups respectively. The combined exercise-LLLT group showed better acute and long-term benefits with participants experiencing a 3.5 centimetre decrease in knee circumference, 24 point improvement in the WOMAC pain and functionality scale, and a four repetition increase in physical functionality.
Conclusion: The findings suggest that LLLT is a viable tool for managing KOA when used in conjunction with physical exercise.
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Kushibiki, Toshihiro, Takeshi Hirasawa, Shinpei Okawa, and Miya Ishihara. "Low Reactive Level Laser Therapy for Mesenchymal Stromal Cells Therapies." Stem Cells International 2015 (2015): 1–12. http://dx.doi.org/10.1155/2015/974864.
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Low reactive level laser therapy (LLLT) is mainly focused on the activation of intracellular or extracellular chromophore and the initiation of cellular signaling by using low power lasers. Over the past forty years, it was realized that the laser therapy had the potential to improve wound healing and reduce pain and inflammation. In recent years, the term LLLT has become widely recognized in the field of regenerative medicine. In this review, we will describe the mechanisms of action of LLLT at a cellular level and introduce the application to mesenchymal stem cells and mesenchymal stromal cells (MSCs) therapies. Finally, our recent research results that LLLT enhanced the MSCs differentiation to osteoblast will also be described.
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de Oliveira, Helenita Antonia, Ednei Luiz Antonio, Gisela Arsa, Eduardo Tadeu Santana, Flávio André Silva, Daniel Arruda Júnior, Simone dos Santos, et al. "Photobiomodulation Leads to Reduced Oxidative Stress in Rats Submitted to High-Intensity Resistive Exercise." Oxidative Medicine and Cellular Longevity 2018 (2018): 1–9. http://dx.doi.org/10.1155/2018/5763256.
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The aim of this study was to determine whether oxidative stress markers are influenced by low-intensity laser therapy (LLLT) in rats subjected to a high-intensity resistive exercise session (RE). Female Wistar rats divided into three experimental groups (Ctr: control, 4J: LLLT, and RE) and subdivided based on the sampling times (instantly or 24 h postexercise) underwent irradiation with LLLT using three-point transcutaneous method on the hind legs, which was applied to the gastrocnemius muscle at the distal, medial, and proximal points. Laser (4J) or placebo (device off) were carried out 60 sec prior to RE that consisted of four climbs bearing the maximum load with a 2 min time interval between each climb. Lipoperoxidation levels and antioxidant capacity were obtained in muscle. Lipoperoxidation levels were increased (4-HNE and CL markers) instantly post-RE. LLLT prior to RE avoided the increase of the lipid peroxidation levels. Similar results were also notified for oxidation protein assays. The GPx and FRAP activities did not reduce instantly or 24 h after RE. SOD increased 24 h after RE, while CAT activity did not change with RE or LLLT. In conclusion, LLLT prior to RE reduced the oxidative stress markers, as well as, avoided reduction, and still increased the antioxidant capacity.
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Vale, Fernando Alves, Maria Stella Moreira, Fernanda Campos Souza de Almeida, and Karen Muller Ramalho. "Low-Level Laser Therapy in the Treatment of Recurrent Aphthous Ulcers: A Systematic Review." Scientific World Journal 2015 (2015): 1–7. http://dx.doi.org/10.1155/2015/150412.
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Recurrent aphthous ulcers (RAUs) are the most common lesion found in the oral cavity. There is no definitive cure for RAUs and current treatments are aimed at minimizing symptoms. Since low-level laser therapy (LLLT) modulates inflammatory responses, and promotes pain reduction and cellular biostimulation, LLLT can be suggested as an alternative treatment for RAUs. The literature concerning the potential of LLLT in the treatment of RAUs was evaluated. A systematic literature review identified 22 publications, of which only 2 studies were adopted. The eligibility criteria consisted of randomized controlled trials (RCTs). Both RCTs achieved significant results concerning LLLT and pain-level reductions and reduced healing times. Despite the variance in irradiation conditions applied in both studies, very similar wavelengths were adopted. There is accordingly strong evidence that wavelength plays an important role in RAU treatment. Taking into account the different parameters applied by selected RCTs, it is not possible to suggest that a specific protocol should be used. However, in light of the significant results found in both studies, LLLT can be suggested as an alternative for RAU treatment. Additional RCTs should be performed in order to reach a clinical protocol and better understand the application of LLLT in RAU treatment.
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Ribeiro, Tatiana Pinto, Simone Bustamante Nascimento, Claúdia Alessandra Cardoso, Raduan Hage, Janete Dias Almeida, and Emilia Angela Loschiavo Arisawa. "Low-Level Laser Therapy and Calcitonin in Bone Repair: Densitometric Analysis." International Journal of Photoenergy 2012 (2012): 1–5. http://dx.doi.org/10.1155/2012/829587.
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The aim of this work was to evaluate the association of low-level laser therapy (LLLT, 830 nm) and calcitonin in bone repair considering that bone healing remains a challenge to health professionals. Calcitonin has antiosteoclastic action and LLLT is a treatment that uses low-level lasers or light-emitting diodes to alter cellular function. Both are used to improve bone healing. Densitometry is a clinical noninvasive valuable tool used to evaluate bone mineral density (BMD). Sixty male rats were submitted to bone defect with a trephine bur, randomly divided into four groups of 15 animals each: control (C); synthetic salmon calcitonin (Ca); LLLT (La); LLLT combined with calcitonin (LaCa). Animals from Ca and LaCa received 2 UI/Kg synthetic salmon calcitonin intramuscularly on alternate days after surgery. Animals from groups La and LaCa were treated with infrared LLLT (830 nm, 10 mW, 20 J/cm2, 6 s, contact mode). Five animals from each group were euthanized 7, 14, and 21 days after surgery and bone defects were analyzed by densitometry. Statistical analysis showed a significant difference in BMD values in LaCa group at 7 and 21 days (). The results of the densitometric study showed that LLLT (830 nm) combined with calcitonin improved bone repair.
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Arakeeb, Mohamed Ali Ali, Ahmed Abbas Zaky, Tarek Abdel-Hamid Harhash, Walid S. Salem, and Mohamed El-Mofty. "Effect of Combined Application of Growth Factors and Diode Laser Bio-Stimulation on the Osseo Integration of Dental Implants." Open Access Macedonian Journal of Medical Sciences 7, no. 15 (August 12, 2019): 2520–27. http://dx.doi.org/10.3889/oamjms.2019.672.
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BACKGROUND: The success of implants is associated first with their osseointegration, and later on with their survival rate. In recent years, many efforts have been exerted to develop implant design, geometry, materials and techniques to enhance the osseointegration process and also to increase the success rate of implant procedures. New techniques, like leukocyte and platelet-rich fibrin (L-PRF) and low-level laser treatment (LLLT), have been developed to enhance the osseointegration around dental implants.
AIM: This study aims at accelerating bone osseointegration process around dental implant using new techniques to increase the success rate, to allow immediate or early loading of a dental implant, and to make a comparison between the various new techniques in dental implant procedures to figure out which technique will achieve the best results.
METHODS: The study was conducted on a random sample of 40 male patients. Dental implants were placed in the posterior areas of the lower jaw. Patients were divided randomly into 4 groups; control group, LLLT group, L-PRF group and L-PRF plus LLLT group. They were assessed using cone-beam computed tomography (CBCT).
RESULTS: The results showed significant differences between all groups over different measured times. All the groups showed improvement in comparison with Normal group, where L-PRF group showed the best result followed by (L-PRF+LLLT) group, while the LLLT group showed the least improvement in comparison with bothL-PRF group and (L-PRF+LLLT) group.
CONCLUSION: The study demonstrates that L-PRF gives a better performance in the osseointegration around dental implants than LLLT.
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Krueger, Gabriel Francisco, Milene Castilhos de Oliveira, Humberto Thomazi Gassen, Juliana Tomaz Sganzerla, Daniel Simon, Ivana Grivicich, Pedro Antonio González Hernández, and Sergio Augusto Quevedo Miguens-Jr. "Evaluation of Aquaporins 1 and 5 Expression in Rat Parotid Glands After Volumetric Modulated Arc Radiotherapy and Use of Low-Level Laser Therapy at Different Times." Journal of Lasers in Medical Sciences 11, no. 3 (June 21, 2020): 262–67. http://dx.doi.org/10.34172/jlms.2020.44.
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Introduction: This experimental study investigated the mRNA expression of aquaporins (AQPs) 1 and 5 in the parotid glands of rats irradiated with volumetric modulated arc therapy (VMAT) and subjected to low-level laser therapy (LLLT) at different time points. Methods: The sample consisted of 30 Wistar rats (Rattus norvegicus) divided into the following groups: control, LLLT alone (LG), radiotherapy alone (RG), and experimental groups that received LLLT at 24 hours (early experimental group [EEG], n=12) and 120 hours (late experimental group [LEG], n=12) after radiotherapy. VMAT was delivered at a single dose (12 Gy) and LLLT was performed with an aluminium-gallium-arsenide diode laser (660 nm, 100 mW), spot area of 0.0028 cm2, energy of 2 J/cm2 applied to 3 spots in the region corresponding to the right parotid gland, for 10 consecutive days. The right parotid gland was resected and prepared for RNA extraction. The gene expression of AQPs was evaluated by quantitative polymerase chain reaction (qPCR) using specific TaqMan probes, with the HPRT gene as an internal control. Results: The lowest AQP1 gene expression was 0.83 (0.27) with the use of LLLT 24 hours after radiotherapy (EEG), and the highest was 1.56 (0.80) with the use of LLLT alone (LG). Likewise, the lowest AQP5 gene expression was found in the EEG (mean = 0.88; SD = 0.49) and the highest in the LG (mean = 1.29; SD = 0.33). Conclusion: The use of LLLT after radiotherapy may contribute to the maintenance and an increase of these proteins, even when used at a later time point after radiotherapy.
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Alfredo, Patrícia Pereira, Jan Magnus Bjordal, Washington Steagall Junior, Rodrigo Álvaro Brandão Lopes-Martins, Martin B. Stausholm, Raquel Aparecida Casarotto, Amélia Pasqual Marques, and Jon Joensen. "Long-term results of a randomized, controlled, double-blind study of low-level laser therapy before exercises in knee osteoarthritis: laser and exercises in knee osteoarthritis." Clinical Rehabilitation 32, no. 2 (August 4, 2017): 173–78. http://dx.doi.org/10.1177/0269215517723162.
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Objectives: To assess the long-term effects of low-level laser therapy (LLLT), in combination with strengthening exercises in patients with osteoarthritis of the knee. Design: Follow-up results at three and six months in a previously published randomized, double-blind, placebo-controlled trial. Setting: Specialist Rehabilitation Services. Subjects: Forty participants of both genders, aged 50–75 years with knee osteoarthritis grade 2–4 on Kellgren–Lawrence scale. Intervention: The LLLT group received 10 LLLT treatments with invisible infrared laser (904 nm, 3 Joules/point) over three weeks followed by an eight-week supervised strengthening exercise program. The placebo LLLT group received identical treatment, but the infrared laser output was disabled. Main measures: Pain on a visual analogue scale, paracetamol consumption, and osteoarthritis severity measured by the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and Lequesne Index. Results: The new data obtained during the follow-up period showed that all outcomes remained stable and there were no significant differences between the groups at three and six months. However, daily consumption of rescue analgesics (paracetamol) was significantly lower in the LLLT group throughout the follow-up period, ending at a group difference of 0.45 vs. 3.40 units ( P < 0.001) at six months follow-up. We conclude that within the limitations of this small study, the previously reported improvement after LLLT plus exercise was maintained for a period of six months. Conclusion: We find that the immediate post-intervention improvements from LLLT plus strengthening exercises were maintained for six months.
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OTSUKA, Hiroshi, Rie NUMAZAWA, Toshikazu HASHIMOTO, and Osamu KEMMOTSU. "Pain Management with LLLT." JOURNAL OF JAPAN SOCIETY FOR LASER SURGERY AND MEDICINE 18, no. 1 (1997): 19–25. http://dx.doi.org/10.2530/jslsm1980.18.1_19.
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Harila, A. "96 LLLT for scoliosis." Photodiagnosis and Photodynamic Therapy 9 (August 2012): S33. http://dx.doi.org/10.1016/s1572-1000(12)70097-2.
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Yoshida, Kenji. "LLLT FOR FACIAL PALSY." LASER THERAPY 19, no. 3 (2010): 167–69. http://dx.doi.org/10.5978/islsm.19.167.
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Koticha, Paloni, Farhin Katge, and Vamsikrishna Chimata. "The Effect of Low Level Laser Therapy and Acupressure in Controlling Gag Reflex in Children Undergoing Dental Procedures." International Journal of Science and Healthcare Research 6, no. 2 (April 2, 2021): 1–8. http://dx.doi.org/10.52403/ijshr.20210401.
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Background: Impression making can be challenging in children due to the exaggerated gag reflex. It not only hinders the basic dental examination procedure but also delivery of the treatment procedure becomes more challenging. Aim: Comparative evaluation of Low Level Laser Therapy (LLLT) and in combination with acupressure in controlling gag reflex in children undergoing impression making procedure. Experimental Procedure: A total of 90 children (10.1 + 2.6) years were divided into three groups depending upon the strategies used. Group A received LLLT whereas group B received LLLT with acupressure and group C was placebo group. Each patient underwent two impressions to record GSI and GPI scores for all groups. Results: Mean values of GSI and GPI scores for each group were calculated at three different stages. The mean values revealed least gagging with LLLT as compared to LLLT with acupressure and placebo group at stage 1 (p-0.001) and stage 3 (p-0.000) which was statistically significant. Mean values of GPI score was less than GSI score at all three stages for all the groups except for stage 1 in group C, which was not statistically significant. Conclusion: LLLT and in combination with acupressure was effective in controlling gag reflex in comparison to acupressure in children undergoing impression making procedure. Keywords: Acupuncture, acupressure, acupoints, gag reflex, impression making.
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Rogatko, Cleo, Rachel Tennant, and Wendy Baltzer. "Preoperative low level laser therapy in dogs undergoing tibial plateau levelling osteotomy: A blinded, prospective, randomized clinical trial." Veterinary and Comparative Orthopaedics and Traumatology 30, no. 01 (2017): 46–53. http://dx.doi.org/10.3415/vcot-15-12-0198.
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SummaryObjective: To evaluate the influence of pre-operative low-level laser therapy (LLLT) on therapeutic outcomes of dogs undergoing tibial plateau levelling osteotomy (TPLO).Methods: Healthy dogs undergoing TPLO were randomly assigned to receive either a single preoperative LLLT treatment (800–900 nm dual wavelength, 6 W, 3.5 J/cm2, 100 cm2 area) or a sham treatment. Lameness assessment and response to manipulation, as well as force plate analysis, were performed pre-operatively, then again at 24 hours, two weeks, and eight weeks postoperatively. Radiographic signs of healing of the osteotomy were assessed at eight weeks postoperatively.Results: Twenty-seven dogs (27 stifles) were included and no major complications occurred. At eight weeks postoperatively, a significant difference in peak vertical force analysis was noted between the LLLT (39.6% ± 4.7%) and sham groups (28.9% ± 2.6%), (p <0.01 Time, p <0.01 L). There were no significant differences noted between groups for all other parameters. The age of dogs in the LLLT group (6.6 ± 1.6 years) was greater than that for the sham group (4.5 ± 2.0, p <0.01). Although not significant, a greater proportion of LLLT dogs (5/8) had healed at the eight-week time point than in the sham group (3/12) despite the age difference (p = 0.11)Clinical significance: The results of this study demonstrate that improved peak vertical force could be related to the preoperative use of LLLT for dogs undergoing TPLO at eight weeks postoperatively. The use of LLLT may improve postoperative return to function following ca-nine osteotomies and its use is recommended.Supplementary Material to this article is available online at https://doi.org/10.3415/VCOT-15-12-0198.
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Abdelbasset, Walid Kamal, Gopal Nambi, Saud F. Alsubaie, Ahmed M. Abodonya, Ayman K. Saleh, Nahla N. Ataalla, Ahmed A. Ibrahim, et al. "A Randomized Comparative Study between High-Intensity and Low-Level Laser Therapy in the Treatment of Chronic Nonspecific Low Back Pain." Evidence-Based Complementary and Alternative Medicine 2020 (October 28, 2020): 1–6. http://dx.doi.org/10.1155/2020/1350281.
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Objectives. Chronic nonspecific low back pain (chronic nsLBP) is one of the most common musculoskeletal disorders leading to disabilities and physical inactivity. Laser therapy was used in chronic nsLBP treatment; however, no previous studies have assessed the impacts of high-intensity laser therapy (HILT) versus low-level laser therapy (LLLT) on chronic nsLBP. This study compared the effects of HILT versus LLLT on individuals suffering from chronic nsLBP. Methods. The study was a randomized control trial. Sixty individuals with chronic nsLBP were enrolled in this study between May and November 2019. All participants were clinically diagnosed with chronic nsLBP. They were assigned randomly into three groups, 20 in each group. The first group received a program of LLLT, the second group received a program of HILT, and the third did not receive laser therapy (control group). Pain severity, disability, lumbar mobility, and quality of life were assessed before and after 12-week intervention. Results. Both LLLT and HILT groups showed a significant improvement of the Oswestry Disability Index (ODI), visual analogue scale (VAS), lumbar range of motion (ROM), and European Quality of Life (EuroQol) scores ( p > 0.05 ), while the control group did not show significant changes ( p > 0.05 ). Comparison among the three study groups postintervention showed significant differences in the outcome measures ( p > 0.05 ), while comparison between the LLLT and HILT groups showed nonsignificant differences ( p > 0.05 ). Conclusion. There are no different influences of LLLT versus HILT on chronic nsLBP patients. Both LLLT and HILT reduce pain and disability and improve lumbar mobility and quality of life in chronic nsLBP patients.
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Simanjuntak, Charles A., and Patrick W. Gading. "Comparison Effect of Corticosteroid Injection with Low Level Laser Therapy in Plantar Fasciitis Patients in Dr. Bratanata Hospital, Jambi." Orthopaedic Journal of Sports Medicine 7, no. 11_suppl6 (November 1, 2019): 2325967119S0047. http://dx.doi.org/10.1177/2325967119s00470.
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Objectives: Plantar fasciitis is a common pain disorder that affects the heel and soles of the feet. These are abnormalities at the location of tendon insertions in the bone and are characterized by scarring, inflammation, or damage to the plantar fascia. Treatment options for patients with plantar fasciitis vary with little consensus on the clinical approach. Physical therapy procedures including LLLT (Low-Level Laser Therapy) are most often applied in conservative treatment of plantar fasciitis. While steroid injection is a treatment that has been proven effective in the management of short-term symptoms. The aim of this study was to compare the effects of LLLT and steroid injection on pain and functional conditions in patients with plantar fasciitis. Methods: This is a prospective study conducted in 30 patients. 15 patients were treated with local injection steroids (single Group A) and 15 patients were treated with LLLT (Group B), 8 J / cm2 per day, 3 days per week for 2 weeks. VAS scores and FFI (Foot Function Index) are measured. Results: Pain intensity was reduced in both groups after 2 weeks. VAS scores decreased to 3.47 in Group A and 3.82 in Group B in 2 weeks (p <0.05). In Group A, FFI decreased to 22.03 ± 4.45 while in Group B it decreased to 26.40 ± 2.52 in the same interval. But generally, patients who suffer from plantar fasciitis prefer LLLT compared to more invasive steroid injection therapy. Conclusion: LLLT therapy and steroid injection are effective methods for reducing pain and improving foot function in plantar fasciitis. It appears that steroid injection is superior to LLLT therapy. But fear of invasive action, patients have LLLT.
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Potapova, Maria K., Sergey Y. Borovets, and Salman K. Al-Shukri. "Male autoimmune infertility: analysis of results and prediction of efficacy of low-level laser therapy in infrared spectrum." Urology reports (St. - Petersburg) 11, no. 1 (May 27, 2021): 5–13. http://dx.doi.org/10.17816/uroved60268.
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INTRODUCTION: Autoimmune infertility is diagnosed in 515% of men. Currently applied methods of medical therapy of autoimmune male infertility are not very effective, which requires the development of new ones and creation of predictive algorithms for their efficacy.
The aim of our study was to evaluate the influence of low-level laser therapy (LLLT) in infrared spectrum on MAR-test rate and sperm fertile properties in men with autoimmune infertility, develop ways to predict the efficacy of this therapy.
PATIENTS AND METHODS: 47 men with autoimmune infertility were examined. 31 of them (1st group) underwent course of LLLT in infrared spectrum (10 procedures), and 16 patients (2nd group, comparison) had placebo-laser therapy sessions (10 procedures). MAR-test value, main semen parameters and sperm DNA fragmentation were assessed before and after the treatment. For creation of LLLT efficacy algorithm we used discriminate analysis.
RESULTS: In patients of the 1st group we indicated statistically significant decrease of MAR-test by an average of 19% immediately after the course of procedures, and by 33% within two months after the end of the treatment, at its initial level 60% or lower. LLLT contributed to improvement of the semen fertile properties, pregnancy developed in the natural reproductive cycle in 19% of couples. We developed math model for prediction the efficacy of LLLT in infrared spectrum of autoimmune male infertility.
CONCLUSION: LLLT in infrared spectrum of male autoimmune infertility leads to MAR-test value decrease at its initial level less than 60%; improves sperm fertile properties. It is appropriate to use before LLLT predictive algorithm of its efficacy developed by us.
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Chen, Chih-Hao, Chii-Yuan Huang, Chun-Yu Chang, and Yen-Fu Cheng. "Efficacy of Low-Level Laser Therapy for Tinnitus: A Systematic Review with Meta-Analysis and Trial Sequential Analysis." Brain Sciences 10, no. 12 (December 2, 2020): 931. http://dx.doi.org/10.3390/brainsci10120931.
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Study Objective: Tinnitus is a common disorder characterized by sound in the ear in the absence of external or internal stimuli. Low-level laser therapy (LLLT) was discovered enhancing tissue repair via increasing the blood microcirculation and cell proliferation in 1960s. In the last two decades, LLLT delivered to the cochlea has frequently been used to reduce the severity of tinnitus. However, whether LLLT effectively attenuates the severity of tinnitus remains controversial. We aimed to evaluate the efficacy of low-level laser therapy on adult patients with complaints of tinnitus. Design: Systematic review and meta-analysis with trial sequential analysis. Interventions: Low-level laser therapy (LLLT). Measurements: Tinnitus Handicap Inventory (THI) score; improvement rates of the visual analog scale (VAS), verbal rating scale (VRS) and numeric rating scale (NRS) scores. Methods: We searched PubMed, Embase, Scopus, Web of Science, and the Cochrane Library from inception through 17 September 2020. Randomized control trials that involved adult patients with complaints of tinnitus, compared LLLT to a placebo and provided sufficient information for meta-analysis were considered eligible. Main Results: Overall, 11 studies involving 670 patients were included. No significant difference in the overall effect according to the THI score (mean difference (MD), −2.85; 95% CI, −8.99 to 3.28; p = 0.362; I2 = 0%) and the rating scale score improvement rate (risk ratio (RR), 1.35; 95% CI, 0.81 to 2.27; p = 0.250; I2 = 67%) was demonstrated between patients receiving LLLT and those receiving a placebo. None of the subgroup analyses showed significant differences, regardless of underlying sensorineural hearing loss, the number of irradiation sessions or the wavelength used. Conclusions: Our meta-analysis suggests that the value of LLLT in controlling the severity of tinnitus remains unclear, in part due to the relatively small number of patients and underlying heterogeneity. More large-scale investigations of LLLT for tinnitus related to inner ear disease are required to further elucidate the therapeutic effects.