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Hurwitz, Brian. "Form and Representation in Clinical Case Reports." Literature and Medicine 25, no. 2 (2006): 216–40. http://dx.doi.org/10.1353/lm.2007.0006.
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Amr, Dena, Gregory Broderick-Villa, Philip I. Haigh, J. Michael Guenther, and L. Andrew Difronzo. "Adverse Drug Reactions during Lymphatic Mapping and Sentinel Lymph Node Biopsy for Solid Neoplasms." American Surgeon 71, no. 9 (September 2005): 720–24. http://dx.doi.org/10.1177/000313480507100905.
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Currently, 1 per cent isosulfan blue dye and technetium-99-labeled sulfur colloid (SC) are used in lymphatic mapping (LM). Several reports have suggested that the incidence of adverse drug reactions (ADRs) during LM is high. We report our experience with LM for solid neoplasms in order to determine the incidence and risk factors for development of ADRs. Seven hundred fifty-three patients (90% women, mean age 57) underwent LM with blue dye alone or in combination with SC from 1998 to 2004. The most common malignancy was breast cancer (83%). One hundred ten patients (14%) had injection of both mapping agents. Most patients (87%) underwent intraparenchymal injection of LM agent. Eight patients (1.1%) had an ADR during LM; none had prior exposure to LM. Of these, 7 had limited reactions (mostly blue hives) that quickly resolved. One patient (0.1%) developed anaphylaxis. The ADR incidence in patients with a sulfa allergy was not significantly different than that in patients without a sulfa allergy (3.4 vs 1%, P = 0.12). No risk factors for development of ADR were identified. Overall, the incidence of ADR during LM is low. Patients with sulfa allergies and prior exposure to LM did not demonstrate an increased incidence of ADR. Anaphylaxis, though rare, can occur during LM.
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Macnab, Magnus, and Patrick Kenny. "Successful Intravenous Immunoglobulin Treatment of Atypical Lichen Myxedematosus Associated with Hypothyroidism and Central Nervous System Involvement: Case Report and Discussion of the Literature." Journal of Cutaneous Medicine and Surgery 17, no. 1 (January 2013): 69–73. http://dx.doi.org/10.2310/7750.2012.11125.
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Background: Lichen myxedematosus (LM) is a rare idiopathic disorder characterized by papules, plaques, and/or nodules in the skin secondary to mucin deposition and variable dermal fibrosis in the absence of thyroid disease. Case reports are the predominant literature on LM due to its rarity, and the data are limited regarding the disease. No standard treatment regimen exists, and the response to treatment varies. Objective: This report adds to the limited literature on atypical LM associated with thyroid dysfunction and contributes to the growing body of evidence supporting intravenous immunoglobulin (IVIg) as effective therapy for extensive cases. Methods and Results: We report an unusual case of atypical LM associated with hypothyroidism, central nervous system (CNS) disturbances, and atrial fibrillation in a 64-year-old male. The patient experienced remarkable improvement within 3 months of beginning IVIg treatment; however, he required repeat therapy due to the recurrence of CNS symptoms 3 months after treatment. Conclusion: We agree with previous authors that thyroid dysfunction alone should not preclude a diagnosis of LM. Additionally, we contribute to the increasing evidence of IVIg being an effective treatment, particularly in the setting of systemic complications or acute worsening of LM.
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Mickle, James E., Maria Rosaria Barone Lumaga, and Paolo De Luca. "Stomatal Development in Aerial Axes of Psilotum nudum (Psilotaceae)." Journal of North Carolina Academy of Science 128, no. 3-4 (October 1, 2012): 95–99. http://dx.doi.org/10.7572/2167-5880-128.3.95.
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Abstract Apical regions of developing aerial shoots of Psilotum nudum (L.) Beauv. were studied using both scanning electron microscopy (SEM) and light microscopy (LM) with the aim of improving our understanding of early stages in stomatal and epidermal ontogenesis. SEM samples were fixed in gluteraldehyde, critical point dried, and coated with an Au-Pd alloy. LM samples were fixed in FAA and embedded in paraffin. LM sections were stained with 0.05% toluidine blue for protein. SEM shows that P. nudum stomata develop from 20 µm-long domed meristemoid cells into guard cell mother cells (GMCs). A furrow dividing guard cells develops at 30 µm long, and wax deposition that will cover the entire cell begins at 70 µm long. LM longitudinal sections of GMCs show a cytoplasmic protein net that organizes into radial fibers, similar to reports of actin fibers in stomata of angiosperms. This study provides additional details of stomatal development in Psilotum and is the first report of an actin-like protein net in Psilotum.
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MacGillivray, J. A., L. H. Sackett, J. M. Driessen, and S. Hemingway. "Excavations at Palaikastro, 1991." Annual of the British School at Athens 87 (November 1992): 121–52. http://dx.doi.org/10.1017/s0068245400015070.
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The fifth excavation season at Palaikastro is reported. The principal discoveries are a floor deposit of the EM III/MM I A period, a well stratified sequence of levels from the MM II A to MM III B/LM I A periods, floor levels of the LM II and LM III AI periods, and a floor deposit of the LM III A2/B period with storage jars and a bull's head rhyton. Also noteworthy are the discovery of mason's marks on the N facade of Building 5, and fragments of the finest example of painted plaster found at Palaikastro. S. Hemingway reports an important group of metalworking artefacts from a LM III A2/B deposit.
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Christo, Paul J. "Cephalad Lead Migration Following Spinal Cord Stimulation Implantation." Pain Physician 1;15, no. 1;1 (January 14, 2012): E79—E87. http://dx.doi.org/10.36076/ppj.2012/15/e79.
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Lead migration (LM) is the most common complication after spinal cord stimulation (SCS). Although multiple reports of caudad LM have been described, cephalad LM has not been reported. Here we describe a case in which a stimulator lead migrates in the cephalad direction. A 60-year-old male with failed back surgery syndrome underwent SCS lead implantation via a dual lead approach to the top of vertebral body (VB) T9. A standard strain relief loop was used for each lead in the paramedian pocket. Postoperative testing revealed 100% paresthesia coverage of the painful areas. For the first 4 days, the patient continued to have excellent coverage; however, by the seventh day, the paresthesias ascended to above the nipple line. At the 2-week follow-up, cephalad migration of the left lead to the top of VB T1 was confirmed on fluoroscopy. The patient underwent successful lead revision in which a single paramedian incision technique was used to place extra sutures and a “figure-of-eight” strain relief loop. We provide the first case report of significant cephalad LM following SCS lead implantation. This migration can occur despite the use of current standard anchoring techniques. Additional investigation into the mechanism of such LM and lead-securing techniques is warranted. Key words: spinal cord stimulation, lead migration, lead revision, strain relief loop
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Pata, Giacomo, Claudio Casella, Francesco Mittempergher, Laura Cirillo, and Bruno Salerni. "Loupe Magnification Reduces Postoperative Hypocalcemia after Total Thyroidectomy." American Surgeon 76, no. 12 (December 2010): 1345–50. http://dx.doi.org/10.1177/000313481007601218.
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We aimed to evaluate the impact of loupe magnification (LM) on incidental parathyroid gland removal (from pathology reports), hypocalcemia, and recurrent laryngeal nerve (RLN) injury after total thyroidectomy and answer the question of whether this tool should be always recommended for patient's safety. Between January 2005 and December 2008, 126 patients underwent total thyroidectomy with routine use of 2.5 X galilean loupes; their charts were compared with data on 118 patients operated on between January 1997 and December 2000 without LM (two different equally skilled surgical teams operating in the two periods). LM decreased the rate of inadvertent parathyroid glands removal (3.8 vs 7.8% of total parathyroid glands; P = 0.01), as well as of biochemical (20.6 vs 33.9%; P = 0.028) and clinical (12.7 vs 33%; P = 0.0003) hypocalcemia after thyroidectomy. All cases (16 of 16) of symptomatic hypocalcaemia in the LM group proved to be associated with parathyroidectomy vs 76.9 per cent (30 of 39) without LM ( P = 0.046). A trend toward decreased RLN injury rate, although statistically insignificant, was reported, being unilateral transient, unilateral permanent, and bilateral transient palsy rates 6.8, 2.5, and 1.7 per cent, respectively, without LM vs 4.8, 2.4, and 0.8 per cent, respectively, with LM ( P = 0.69; P = 1, and P = 0.61, respectively). Our results do support the routine use of LM during total thyroidectomy.
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Laakmann, Elena, Isabell Witzel, and Volkmar Müller. "Efficacy of Liposomal Cytarabine in the Treatment of Leptomeningeal Metastasis of Breast Cancer." Breast Care 12, no. 3 (2017): 165–67. http://dx.doi.org/10.1159/000464400.
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Background: Breast cancer is one of the most frequent causes of leptomeningeal metastasis (LM) among solid tumors in adults. The prognosis of patients with LM is poor. A treatment option is the intrathecal administration of liposomal cytarabine. Case Reports: The first case represents a 53-year-old woman with LM of breast cancer. A neurological response was achieved shortly after the start of the multimodal treatment including intrathecal liposomal cytarabine. The response duration reached 79 days. The second case represents a 48-year-old woman with LM of breast cancer treated with intrathecal liposomal cytarabine as a part of a multimodal treatment approach. A neurological response was achieved in the first 2 weeks of treatment and is still lasting after 18 months. Conclusion: These cases suggest that a rapid response to a prompt start of treatment with intrathecal liposomal cytarabine in patients with LM of breast cancer is feasible. In 1 case an extremely long progression-free survival (18+ months) was achieved. The cases support the efficacy of liposomal cytarabine in the management of LM in breast cancer patients as a part of a multimodal treatment approach and underline the need for further investigations in this specific cohort.
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Montaudié, Henri, Florence Le Duff, Catherine Butori, Veronique Hofman, Eric Fontas, Coralie Roger, Philippe Bahadoran, et al. "Ingenol mebutate to treat lentigo maligna of the head (face and scalp): A prospective and multicenter single-arm phase 2 trial." Journal of Clinical Oncology 37, no. 15_suppl (May 20, 2019): e21051-e21051. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.e21051.
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e21051 Background: Ingenol mebutate gel is indicated for the treatment of actinic keratoses. In vitro, it has been shown that ingenol mebutate can induce the apoptosis of melanoma cells, but robust clinical data are missing with only few case reports reported.The objectives of the current study was to assess the efficacy and safety of ingenol mebutate for the treatment of lentigo maligna (LM). Methods: We conducted a prospective, multicentre, and single-arm phase 2 trial (NCT02723721), from June 2016 to November 2017. This trial was planned according to Simon’s optimal two-stage design for a total sample size of 23 subjects. Adults with LM of the head were included. Ingenol mebutate gel 150 µg/g was applied daily for 3 consecutive days (one cycle). For patients having no remission or only partial remission at 2 months, a second cycle was done. Patients were evaluated 2 months after the (re)treatment and then every 3 months for 36 months if a complete response (CR) was obtained. The primary endpoint was the CR, defined as the complete clearing of the LM evaluated at 2 months clinically and histologically. Results: Twelve patients with a median age of 73 years were recruited. Only 2 achieved a CR; one patient relapsed during the first year following the treatment. Forty-seven adverse events related to ingenol mebutate were declared. Most were grade 3-4 (66%), but all were resolved without any sequelae. The mean maximum local skin reaction score was 12 (min: 3 – max: 22). These results should be interpreted with caution, because this study has limitations, such as the lack of a comparative arm and the heterogeneity of LM (size and localization). Conclusions: To our knowledge, we report the first prospective study evaluating the efficacy and safety of IM in patients with LM of the head. Unfortunately ingenol mebutate is not an effective treatment of LM in this indication at the concentration of 150 µg/g. Its use with a more intense regimen (more cycles and/or highest concentration (500 µg/g)) is also limited by a poor safety profile. Clinical trial information: NCT 02723721.
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Holmgren, Robin A., Nancy Eisenberg, and Richard A. Fabes. "The Relations of Children’s Situational Empathy-related Emotions to Dispositional Prosocial Behaviour." International Journal of Behavioral Development 22, no. 1 (March 1998): 169–93. http://dx.doi.org/10.1080/016502598384568.
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Although empathy-related responding has frequently been associated with prosocial behaviour directed towards the target of an individual’s vicarious emotional responding, relations between dispositional prosocial behaviour and sympathy or personal distress have seldom been examined, particularly with a multimethod approach. Kindergarten to third-graders’ empathy-related responses to a ”lm were examined as predictors of dispositional prosocial behaviour as reported by teachers, parents, and peers. Teachers’ ratings of dispositional behaviour were related to children’s facial and skin conductance reactions to the ”lm. Parents’ and peers’ ratings of dispositional prosocial behaviour were infrequently associated with children’s empathy-related responding, although peer reports were positively related to heart rate acceleration for boys. Reasons for the differential patterns of relations for different reporters are considered.
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Soetemans, Lise, Natasja Gianotten, and Leen Bastiaens. "Agri-Food Side-Stream Inclusion in The Diet of Alphitobius Diaperinus. Part 2: Impact on Larvae Composition." Insects 11, no. 3 (March 17, 2020): 190. http://dx.doi.org/10.3390/insects11030190.
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Insects are gaining interest as an alternative protein source for feed/food purposes. Although the lesser mealworm (LM) is commercially produced for human consumption, published data on its nutrient composition is scarce. This study reports on LM larvae reared on 18 different diets composed of side-streams to (1) determine the nutritional composition of the larvae and (2) study the effect of dietary changes on the larval nutrient composition. The LM larvae proved to be of good nutritional value with essential amino acids profiles comparable with that of beef and linoleic acid (C18:2) was the most dominant essential fatty acids in the larvae. The side-stream based diets varied on dry matter basis in protein (16–34%) and lipid content (2–19%). The nutrient content of the larvae reared on diets that supported good growth ranged between 37% and 49% of protein, 22% and 26% of lipid and 4% to 6% of chitin on dry matter basis. No significant correlations were identified between the larval protein or lipid content and that of the diet, but it was found between the diet nutrients and larval growth. Based on larval growth data and economic considerations, diets composed of wheat middlings with a 10–15% inclusion of rapeseed meal were identified as suitable feed for LM. Highest larval yields were obtained with diets containing 15–22% of proteins and 5–10% of lipids.
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Blanchet, Conor J. K., Eric J. Fish, Amy G. Miller, Laura A. Snyder, Julia D. Labadie, and Paul R. Avery. "Evaluation of Region of Interest Digital Cytology Compared to Light Microscopy for Veterinary Medicine." Veterinary Pathology 56, no. 5 (May 21, 2019): 725–31. http://dx.doi.org/10.1177/0300985819846874.
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Digital microscopy (DM) has been employed for primary diagnosis in human medicine and for research and teaching applications in veterinary medicine, but there are few veterinary DM validation studies. Region of interest (ROI) digital cytology is a subset of DM that uses image-stitching software to create a low-magnification image of a slide, then selected ROI at higher magnification, and stitches the images into a relatively small file of the embedded magnifications. This study evaluated the concordance of ROI-DM compared to traditional light microscopy (LM) between 2 blinded clinical pathologists. Sixty canine and feline cytology samples from a variety of anatomic sites, including 31 cases of malignant neoplasia, 15 cases of hyperplastic or benign neoplastic lesions, and 14 infectious/inflammatory lesions, were evaluated. Two separate nonblinded adjudicating clinical pathologists evaluated the reports and diagnoses and scored each paired case as fully concordant, partially concordant, or discordant. The average overall concordance (full and partial concordance) for both pathologists was 92%. Full concordance was significantly higher for malignant lesions than benign. For the 40 neoplastic lesions, ROI-DM and LM agreed on general category of tumor type in 78 of 80 cases (98%). ROI-DM cytology showed robust concordance with the current gold standard of LM cytology and is potentially a viable alternative to current LM cytology techniques.
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Kobus, Jörn, Markus Westner, Susanne Strahringer, and Diane Strode. "Enabling digitization by implementing Lean IT: lessons learned." TQM Journal 30, no. 6 (October 8, 2018): 764–78. http://dx.doi.org/10.1108/tqm-02-2018-0026.
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Purpose With the rise of digitization, IT organizations are challenged to provide efficient service delivery and offer innovative digital solutions while maintaining a constant resource capacity. To address this challenge, some IT organizations have adopted Lean Management (LM). Although LM is a standard production mode in manufacturing, it is less familiar to IT organizations. The purpose of this paper is to identify 12 lessons learned from companies who implemented LM in their IT organization (Lean IT) to free up their IT resource capacity from existing day-to-day operations so they could use it to enable their digitization strategy. Design/methodology/approach A case study of two major international companies from different industries. Data were collected from 25 structured interviews. Findings The lessons learned provide insights into how these companies implemented Lean IT, the potential outcomes they aimed for, what they did to achieve those outcomes, how they facilitated the implementation of Lean IT, and restrictions they encountered during the implementation. Research limitations/implications The findings are based on a limited range of IT organizations. Practical implications The lessons learned inform those implementing Lean IT because they explain how companies have implemented Lean IT to facilitate digitization and the benefits and pitfalls they encountered. A comparison of Lean IT and Lean Production shows that LM is transferable to IT organizations if domain specific requirements are respected. Originality/value This paper reports the unique experience of companies implementing Lean IT, which can inform other companies in a similar situation.
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Giacalone, Guido, Takumi Yamamoto, Florence Belva, Akitatsu Hayashi, Yoav Dori, Menekhem M. Zviman, Mieke Gysen, Hannah H. Nam, Matthew A. Jolley, and Motoi Kato. "The Application of Virtual Reality for Preoperative Planning of Lymphovenous Anastomosis in a Patient with a Complex Lymphatic Malformation." Journal of Clinical Medicine 8, no. 3 (March 15, 2019): 371. http://dx.doi.org/10.3390/jcm8030371.
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The management of lymphatic malformations (LMs) is challenging, particularly for large and complex lesions involving anatomical structures in the adjacent tissue. While lymphovenous anastomosis (LVA) has been reported as an effective treatment for lymphedema, it has hardly been described as a treatment for LM. Virtual reality has the ability to visualize human structures in three dimensions and can be used for the preoperative planning of complex cases. Here, we describe the first case of the management of an LM by LVA preoperatively planned with virtual reality. A young woman presented with an LM previously treated by gross excision. Following persistent complaints of swelling, a minimally invasive microsurgical intervention was planned. The results of the single photon emission tomography with computed tomography (SPECT-CT) and lymphoscintigraphy were analyzed using a virtual reality program, and a 3D patient-specific model was constructed. Based on the combined findings of this 3D model and lymphography with a fluorescent marker, a precise skin incision could be determined and one lymph vessel was anastomosed to a nearby vein. The swelling of the thigh reduced and the discomfort disappeared. Although more reports are needed to confirm its efficacy, LVA planned with virtual reality constructed images appears to be a valuable treatment option for complex lesions, including LMs.
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Berdeja, Jesus G., Francisco Hernandez-Ilizaliturri, Asher Chanan-Khan, Manish Patel, Kevin R. Kelly, Kelli L. Running, Mary Murphy, et al. "Phase I Study of Lorvotuzumab Mertansine (LM, IMGN901) in Combination with Lenalidomide (Len) and Dexamethasone (Dex) in Patients with CD56-Positive Relapsed or Relapsed/Refractory Multiple Myeloma (MM)." Blood 120, no. 21 (November 16, 2012): 728. http://dx.doi.org/10.1182/blood.v120.21.728.728.
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Abstract Abstract 728 Background: LM, an antibody-drug conjugate (ADC), is designed to specifically kill CD56+ cancer cells and contains a potent maytansinoid cytotoxic agent (DM1) attached to a CD56-targeting antibody. MM shows CD56 expression in >70% of cases. LM has demonstrated single agent clinical activity and an acceptable safety profile in relapsed/refractory (rel/ref) MM patients. Preclinical studies showed enhanced anti-MM activity when LM was combined with Len/Dex. To further study the safety and efficacy of LM in combination with Len/Dex, a phase I study was conducted in rel/ref patients. This abstract reports updated results on the safety and efficacy of LM/Len/Dex and preliminary results on the pharmacokinetics (PK) and immunogenicity studies. Methods: Primary study objectives were to determine the safety, maximum tolerated dose (MTD), recommended phase 2 dose (RP2D), anti-MM activity and PK of LM in combination with standard oral (PO) doses of Len (25 mg po, daily on days 1–21) and Dex (40 mg po on D 1, 8, 15, and 22) in CD56+ rel/ref MM patients who have received at least 1 prior therapy. LM was given intravenously (IV) on D 1, 8, and 15 on a 28-day cycle. Dose escalation was conducted in new cohorts of patients to define the MTD, which was then further evaluated in a dose-expansion cohort. Adverse events (AEs) were assessed using CTCAEv3 criteria, and dose-limiting toxicity (DLT) determination was based on the occurrence of AEs that were probably or definitely attributed to the study regimen. Efficacy was assessed using the International Myeloma Working Group (IMWG) criteria. Enrollment has completed and 16 patients remain on study. Results: Forty-four patients were enrolled, 41 are currently evaluable for safety and 32 are evaluable for efficacy. The median number of prior therapies was 2 (range 1–11), 62% of patients had prior Len exposure and 33% were Len refractory. LM doses of 75 (N = 11), 90 (N=4), and 112 (N =6) mg/m2 were evaluated in the dose-escalation phase. The most common AE was peripheral neuropathy (PN), which occurred more frequently at higher LM doses (55% at 75 mg/m2 and 100% at 90 and 112 mg/m2); Grade 3 PN was seen only in patients treated at 90 mg/m2 or above. PN emerged, in most cases, in cycles >3 and was manageable with LM dose modification. During dose escalation, 1 patient experienced Grade 4 neutropenia and hyperuricemia. The 75 mg/m2 LM dose was considered the MTD based on overall tolerability and the lower incidence of PN observed, and was further tested to determine its suitability as the RP2D in the dose expansion portion of the study (N=23 patients, 19 patients available for safety evaluation). Grade 1–2 PN occurred in 8 patients (42%) and grade 3 PN was observed only in 1 pt in the dose-expansion cohort. Two patients developed grade 3 tumor lysis syndrome (TLS). Other grade 3 AEs reported in 1 patient each (5%) in the dose-expansion cohort consisted of neutropenia, thrombocytopenia, anemia, hemolytic anemia, and LDH increase. Efficacy was observed across all dose levels and the overall response rate (ORR) was 59%, including 1 patient each with stringent complete response (sCR) and complete response (CR), 8 patients with very good partial remission (VGPR), and 9 patients with partial remission (PR). No immunogenicity against the antibody (HAHA) or DM1 component (HADA) of LM was detected. PK results from 18 patients treated at 75 mg/m2 indicate LM Cmax and exposure in this combination regimen is consistent with LM monotherapy. Conclusions: Based on all available safety data, 75 mg/m2 was considered the RP2D. LM at 75mg/m2 in combination with Len and Dex has shown objective evidence of clinical activity with an acceptable safety profile. Disclosures: Off Label Use: Lorvotusumab mertansine is not FDA approved for treatment of multiple myeloma alone or in combination with lenalidomide and dexamethasone as is investigated in this trial. Running:ImmunoGen, Inc.: Employment. Murphy:ImmunoGen, Inc.: Employment. Guild:ImmunoGen, Inc.: Employment. Carrigan:ImmunoGen, Inc: Employment. Ladd:ImmunoGen, Inc.: Employment. Wolf:ImmunoGen, Inc.: Employment, Equity Ownership. O'Leary:ImmunoGen, Inc.: Employment. Ailawadhi:Millenium Pharmaceuticals: Speakers Bureau.
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Perrin, Joy M., and Justin Daniel. "Administration and cross-functional teams in libraries." Library Management 38, no. 4/5 (June 13, 2017): 219–25. http://dx.doi.org/10.1108/lm-08-2016-0066.
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Purpose The purpose of this paper is to assist library administration in avoiding cross-functional team pitfalls. Design/methodology/approach This paper reports the results of years of cross-fucntiional teams at an academic Library. Reports results of years of cross-functional teams at an academic Library. Findings Through shared trial and errors, readers will be able to avoid pitfalls and formulate questions not previously considered for their pursuit of cross-functional teams. Research limitations/implications While this is a case study, the lessons learned can be applied at any library where cross-functional teams are considered. Originality/value This study provides an account of teams at an academic library spanning a decade. Trials and tribulations are discussed.
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Thanki, S. J., and Jitesh Thakkar. "Status of lean manufacturing practices in Indian industries and government initiatives." Journal of Manufacturing Technology Management 25, no. 5 (May 27, 2014): 655–75. http://dx.doi.org/10.1108/jmtm-05-2012-0057.
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Purpose – The purpose of this paper is to report a pilot study on lean awareness and implementation using the survey data collected from about 32 industries situated in western and eastern region of India. Design/methodology/approach – A survey instrument containing 45 statements was designed to assess respondents’ attitude and awareness toward lean practices and to explore the level of lean implementation in the organization. The instrument was distributed personally or through mail to the employees of 32 industries and they were supported for any query about the questions. Descriptive statistical analysis, hierarchical cluster analysis and ANOVA were used to analyze the data with SPSS statistical software. Findings – The research uncovers the fact that the current status of lean implementation and awareness in Indian industries is not so encouraging and the reason for that is, the human-related issues are not tackled properly. Quality and process technology, are the two key areas where industries are indicating inadequate efforts and poor insight. Research limitations/implications – The study conducted was limited to 32 industries situated in the eastern and western region of India. The data collected for few industries rely on only one respondent. Practical implications – The study identifies the lean implementation status based on nine lean assessment key areas and uncovers the major roadblocks for lean practices in Indian industries. It provides key insights to lean practicing industries and lean practitioner about the major barriers and key areas for the improvement. Originality/value – The paper reports comprehensive insights on current awareness and implementation of lean manufacturing (LM) in India. It also highlights the initiatives taken by Government of India to increase the competitiveness of the Indian industries, specifically of manufacturing sector, through the adoption of LM techniques. This would provide a platform for carrying out a detailed research in LM in Indian context.
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Ayoub, M., and T. Walters. "A218 LISTERIA MONOCYTOGENES MENINGITIS IN A NEWLY DIAGNOSED PATIENT WITH INFLAMMATORY BOWEL DISEASE: A CASE REPORT." Journal of the Canadian Association of Gastroenterology 3, Supplement_1 (February 2020): 92–93. http://dx.doi.org/10.1093/jcag/gwz047.217.
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Abstract Background Anti-Tumor Necrosis Factor (TNF) is a frequently utilized therapy in the treatment of Inflammatory Bowel Disease (IBD). Opportunistic infections are a known but an infrequently encountered complication. Listeria monocytogenes (LM) is an aerobic gram-positive intracellular bacillus. Clinical presentation of infection is host dependent, ranging from self-limited illnesses in immunocompetent individuals to life-threatening sepsis and meningitis in the immunocompromised. TNF plays a crucial role in host’s defense against LM. Although published in adults, few case reports have documented invasive LM in children receiving infliximab (IFX), an anti-TNF agent used in IBD therapy. Aims Describe an adolescent with IBD-unclassified (IBD-U) in whom LM sepsis and meningitis was diagnosed after induction therapy with intravenous (IV) IFX. Methods Case report and literature review. Results A 15-year-old girl presented with 2-week history of progressive abdominal pain, bloody diarrhea, urgency, nocturnal stooling, tenesmus, and weight loss. She had been afebrile, with no history of exposures. Examination revealed pallor and tenderness in the right and left lower quadrants. Investigations showed elevated white cell count (WBC), platelets, inflammatory markers, and low albumin. Abdominal ultrasound showed thickening of the descending and sigmoid colon. Stool multiplex PCR was negative. Colonoscopy showed Mayo 3 pancolitis. The terminal ileum was not intubated and endoscopy was normal. She was diagnosed with IBD-U. Due to poor response to high dose IV steroids, IV IFX (after documenting normal vaccination titers) was given with good clinical response and no adverse effects; she was discharged on tapering prednisone. She re-presented 3 days later with fever, severe headaches, photophobia, and neck stiffness. Her IBD remained quiescent. She had consumed a cold meat sandwich 10 days prior. Antibiotics were started as investigations showed leukocytosis and very high inflammatory markers. Brain MRI showed pus in the lateral ventricles. Cerebrospinal fluid (CSF) analysis showed WBC 1832 x106/L, low glucose, and high protein. Blood and CSF cultures detected LM. She defervesced within 24 hours and completed a 21-day course of Ampicillin monotherapy. 2-month follow up showed IBD in continuous remission on IFX with no neurological sequalae, and a normal brain MRI. Conclusions This is the youngest patient with IBD reported with invasive listeriosis secondary to IFX and adds to 3 cases in children. It highlights the importance of vigilance when evaluating IBD patients with fever during IFX-based therapy. Physicians should be reminded of such patients’ immunocompromised state and their high risk of acquiring opportunistic infections. It is unclear if listeriosis avoidance precautions, currently recommended in pregnant women, should be adopted in patients receiving anti-TNF therapy. Funding Agencies None
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Karmakar, Kajal Kumar, Mir Jamaluddin, Ibrahim Khalil, Bazlur Rashid, Rakibul Islam Litu, Humayun Kabir, AHK Chowdhury, et al. "Stenting of Unprotected Left Main Coronary Artery Stenosis: Immediate out comes in NICVD our Initial Experience." University Heart Journal 10, no. 1 (August 20, 2015): 7–12. http://dx.doi.org/10.3329/uhj.v10i1.24589.
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This study aims to describe the initial experiences and immediate outcomes of percutaneous coronary intervention (PCI) in patients with significant left main coronary artery disease with normal LV function in National Institute of Cardiovascular Diseases (NICVD), Dhaka. Left main coronary artery disease is regarded as an absolute contraindication for coronary angioplasty. Recently several reports on protected or unprotected LMCA stenting or both suggested the possibility of percutaneous intervention for this prohibited area. The study was conducted in National Institute of Cardiovascular diseases & Hospital, Dhaka, Bangladesh. Participants of the study were 100 patients with a diagnosis of critical left main coronary artery disease. Information was collected on their demographic characteristics and clinical history. Relevant physical examination and laboratory investigation were performed. Percutaneous transluminal coronary angioplasty (PTCA) with stent implantation were done in the left main coronary artery and other culprit vessel where required. They were followed up thoroughly during the hospital stay. The study subjects were from 35 to 70 years old. 70 male and 30 female were included in this study. According to the clinical history, 12 lead surface ECG reading and cardiac enzyme analysis 40% patient was diagnosed as unstable angina, 40% presented with chronic stable angina and rest of them presented with old myocardial infarction. Among the study population critically isolated LM disease were 30%, critical left main with other vessels disease were 70%. The pattern of LM disease involvement were osteal 40%, mid shaft 10%, distal bifurcation 30%, entire LM involving bifurcation 20%. Procedural success rate was 100%. No patient faced major advance cardiac events (MACE) during hospital stay. Stenting of unprotected LM coronary artery stenosis may be safe effective alternative to CABG in carefully selected patients with normal LV function. Further studies in larger population of this group are needed to assess late out comes.University Heart Journal Vol. 10, No. 1, January 2014; 7-12
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Yang, James C. H., Sang-We Kim, Dong-Wan Kim, Jong-Seok Lee, Byoung Chul Cho, Jin-Seok Ahn, Dae H. Lee, et al. "Osimertinib in Patients With Epidermal Growth Factor Receptor Mutation–Positive Non–Small-Cell Lung Cancer and Leptomeningeal Metastases: The BLOOM Study." Journal of Clinical Oncology 38, no. 6 (February 20, 2020): 538–47. http://dx.doi.org/10.1200/jco.19.00457.
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PURPOSE In this phase I study (BLOOM), osimertinib, a third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI), was evaluated in patients with leptomeningeal metastases (LMs) from EGFR-mutated (EGFRm) advanced non–small-cell lung cancer (NSCLC) whose disease had progressed on previous EGFR-TKI therapy. PATIENTS AND METHODS Patients with cytologically confirmed LM received osimertinib 160 mg once daily. Objectives were to assess confirmed objective response rate (ORR), duration of response (DoR), progression-free survival (PFS), overall survival (OS), pharmacokinetics (PK), and safety. Additional efficacy evaluations included changes from baseline in CSF cytology and neurologic examination. Measurable lesions were assessed by investigator according to RECIST version 1.1. LMs were assessed by neuroradiologic blinded central independent review (BICR) according to Response Assessment in Neuro-Oncology LM radiologic criteria and by investigator. RESULTS Forty-one patients were enrolled. LM ORR and DoR by neuroradiologic BICR were 62% (95% CI, 45% to 78%) and 15.2 months (95% CI, 7.5 to 17.5 months), respectively. Overall, ORR by investigator was 41% (95% CI, 26% to 58%), and median DoR was 8.3 months (95% CI, 5.6 to 16.5 months). Median investigator-assessed PFS was 8.6 months (95% CI, 5.4 to 13.7 months) with 78% maturity; median OS was 11.0 months (95% CI, 8.0 to 18.0 months) with 68% maturity. CSF tumor cell clearance was confirmed in 11 (28%; 95% CI, 15% to 44%) of 40 patients. Neurologic function was improved in 12 (57%) of 21 patients with an abnormal assessment at baseline. The adverse event and PK profiles were consistent with previous reports for osimertinib. CONCLUSION Osimertinib showed meaningful therapeutic efficacy in the CNS and a manageable safety profile at 160 mg once daily in patients with EGFRm NSCLC and LM.
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Lee, Yoon-Mi, Soo-Kang Kim, Chang-Jun Lee, Ji-Hoon Lee, and Jong-Wook Park. "Synthesis and Hole-Transporting Properties of Various Bicarbazyl Derivatives." Journal of Nanoscience and Nanotechnology 8, no. 9 (September 1, 2008): 4797–802. http://dx.doi.org/10.1166/jnn.2008.ic74.
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This paper reports a new HTL material that has high glass-transition temperatures (Tg) and excellent thermal properties. The synthesized material was N,N-diethyl-3,3′-bicarbazyl (DEBC), N,N-diphenyl-3,3′-bicarbazyl (DPBC) and N,N-dinaphthyl-3,3′-bicarbazyl (DNBC). The device that used DPBC as HTL showed the highest efficiency of 4.95 cd/A and 2.22 lm/W at 10 mA/cm2. This is an improvement by more than 10% from the luminance efficiency of NPB, a commercialized material.
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Motoyama, Munekazu, Hiroki Iwasaki, Miyuki Sakakura, Takayuki Yamamoto, and Yasutoshi Iriyama. "Synthesis of LiCoO2 particles with tunable sizes by a urea-based-homogeneous-precipitation method." International Journal of Materials Research 111, no. 4 (May 1, 2020): 347–55. http://dx.doi.org/10.1515/ijmr-2020-1110411.
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Abstract This paper reports the synthesis of monodisperse spherical LiCoO2 particles in a wide range of average diameter using a urea-based-uniform-precipitation method. The average diameter of LiCoO2 particles can be varied from 2 to 14 lm with a uniform size distribution. The effective approach to maintain the size uniformity while changing the average size of LiCoO2 particles is to keep the ratio of [CO(NH2)2] to [CoSO4] at 8 even when the CoSO4 and urea concentrations are changed.
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Moricca, Salvatore, Alessandra Benigno, Claudia Maria Oliveira Longa, Santa Olga Cacciola, and Giorgio Maresi. "First Documentation of Life Cycle Completion of the Alien Rust Pathogen Melampsoridium hiratsukanum in the Eastern Alps Proves Its Successful Establishment in This Mountain Range." Journal of Fungi 7, no. 8 (July 29, 2021): 617. http://dx.doi.org/10.3390/jof7080617.
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Melampsoridium hiratsukanum is an alien rust fungus which has spread pervasively throughout several European countries following introduction into North Europe at the end of the 20th century. The authenticity of several records of the Melampsoridium species infecting alder (Alnus spp.) in the northern hemisphere is questionable, due to the misidentification and confusion that surround many of the older reports. Given this complicated taxonomic history, and since a M. hiratsukanum-like rust is strongly impacting Alnus incana stands in the Alps, probably affecting the bank protection role of this species along rivers, the unambiguous identification of this pathogen was a pressing epidemiological and ecological issue. In this study, field surveys, light (LM) and scanning electron microscopy (SEM), and molecular characterization were put together in an attempt to solve the conundrum. Field monitoring data, LM and SEM analyses of key taxonomic traits (length of ostiolar cells of uredinium, uredinio-spore shape and size, spore echinulation, number and position of germ pores) and ITS-rDNA sequence-based identification, convergently and unambiguously connected the rust that is causing the current epidemic to the non-native M. hiratsukanum. We documented the completion of the M. hiratsukanum life cycle on its two taxonomically unrelated broadleaf/conifer hosts. This is the first report of M. hiratsukanum from naturally infected Larix decidua in Europe.
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LARI, LEONARD RANG’ALA, Dr LUCY JEPCHOGE RONO, and Prof PHILIP MULAMA NYANGWESO. "DETERMINANTS OF TECHNICAL INEFFICIENCY OF SACCOS IN KENYA: LOAN OUTPUT SLACK ANALYSIS." American Journal of Finance 2, no. 1 (November 7, 2017): 1. http://dx.doi.org/10.47672/ajf.306.
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Purpose: The purpose of this study was to evaluate the determinants of technical inefficiency of Saccos in Kenya.Methodology: The study adopted a descriptive research design. This study collected secondary data analyzed from the audited reports of the licensed deposit taking Saccos and macro-economic indicators sources over the research period. It focuses on environmental and specific Saccos’ predictors affecting inefficiency of Saccos and measured the pure technical inefficiencies of Saccos during a period of pre-regulation and regulation. The explanatory research design was used. The financial reports data collected from a census of 46 Saccos was analyzed at two levels. First involves estimation of technical inefficiency by employing non-parametric DEA method and second concerned determination of inefficiency using parametric SFA. The log truncated panel data was used for a period of 8 years (2007-2014). The study was designed to address general objective of establishing the technical inefficiency, the macro-economic and specific Saccos variables determining the technical inefficiency of Saccos.Findings: The study concludes that all predictors jointly influence inefficiency and that are significant given loan to members’ output slack (LM) or loan output inefficiency. Further, LM slack regression reflects significant random normal error as indicated by Gamma (1.45E-32), and DEA result indicated 0.024 mean inefficiency.Contribution to theory, policy and practice: The regulators or board may not utilize the output loan slack regression to specifically measure the management inefficiency impact on Saccos’ operation while the Saccos predictor variables have significant influence on inefficiency. In addition, the random normal error indicates the influence of agency theory in Saccos is insignificant as the role of management influence given loan slack is minimal. The introduction of variables such as NPTA, MP, FLIB, CA, FI and LP in the financial reports of Saccos and inefficiency benchmarking using DEA and stochastic mechanism are important in regulation.
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Jones, Jeffrey Alan, Joseph M. Flynn, and John C. Byrd. "Rates of Preventable Hospitalization for Ambulatory Care Sensitive Conditions (ACSCs) among Patients with Lymphoid Malignancies (LM)." Blood 112, no. 11 (November 16, 2008): 873. http://dx.doi.org/10.1182/blood.v112.11.873.873.
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BACKGROUND: The influence of comorbid medical illness on treatment outcome and survival from LM has been well-characterized. Recent reports suggest that optimal management of these comorbidities may also be important. We sought to indirectly determine the effectiveness of outpatient treatment for ACSCs, conditions where good outpatient care can potentially prevent the need for hospitalization, by calculating population-based estimates of hospital admission rates among patients with LM. Methods: Data were obtained from the 2005 Nationwide Inpatient Sample. Using ICD-9CM codes, we identified all adult (age ≥20) admissions to U.S. community hospitals for LM (Hodgkin’s disease, non-Hodgkin’s lymphoma, and multiple myeloma). A comparator group without known diagnosis of cancer was created by excluding records containing any diagnosis code for malignant neoplasm or diagnosis/procedure code for cancer treatment. ACSC admissions, including those for short- and long-term complications of diabetes mellitus (DM), uncontrolled DM, asthma, hypertension (HTN), congestive heart failure (CHF), angina, and hypovolemia, were ascertained using algorithms developed and validated for the U.S. Agency for Health Care Research Quality Prevention Quality Indicators. The 2005 5-year prevalence for LM was obtained from SEER and used as the denominator for rate calculations in that group. A denominator for the no cancer group was created using U.S. Census estimates for the 2005 adult population less the SEER 5-year prevalence for all sites. Mean hospital charges were extracted for each admission and transformed into costs using Medicare cost-to-charge ratios. Length of stay, total costs, and in-hospital mortality were compared across groups for each ACSC. All means and proportions were sample weighted. Results: In 2005 there were an estimated 510,300 total LM admissions and 26,700,000 total admissions in the no cancer comparator group. Estimated hospitalization rates for each ASCS and odds ratios for the between group comparisons are detailed below. ACSC Group Admission Rate LM (per 100,000 pop) Admission Rate No Cancer (per 100,000 pop) OR (95% CI) DM Short-term Comp 74.7 33.3 2.25 (1.96–2.57) DM Long-term Comp 286.8 138.6 2.07 (1.93–2.22) DM Uncontrolled 50.4 12.06 4.18 (3.54–4.93) CHF 2360.0 465.5 5.17 (5.04–5.30) HTN 69.3 57.7 1.20 (1.04–1.38) Angina 60.0 21.9 2.74 (2.36–3.20) Asthma 255.4 81.5 3.14 (2.91–3.38) Hypovolemia 1086.5 90.1 12.2 (11.75–12.63) In-hospital mortality did not significantly differ between groups for any ACSC. Mean length of stay and hospital costs were likewise similar with the exception of costs for CHF ($8,957[95%CI 8,260–9,654] v. $7,176 [6,185–8,168]) and length of stay (5.6d [95%CI 4.8–6.3] v. 4.0d [3.9–4.1]) and costs ($8,702 [6,832–10,572] v. $5690[5,373–6,007]) for asthma admissions. Conclusions: Hospitalization of LM patients for ASCSs is common and occurs with odds generally >2 times higher than among patients without a cancer diagnosis. Future studies should be conducted to determine factors influencing these findings (e.g. rates of comorbidity, influence of cancer treatment, utilization of primary care services) and to develop potential strategies for preventing hospital admissions.
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Ren, Xiaoai. "Service decision-making processes at three New York state cooperative public library systems." Library Management 35, no. 6/7 (August 5, 2014): 418–32. http://dx.doi.org/10.1108/lm-07-2013-0060.
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Purpose – The purpose of this paper is to look at the organizational structure and service provisions of cooperative public library systems in New York State. The study also seeks to ask questions of how cooperative public library systems decide what services to provide. Design/methodology/approach – Descriptive statistics, factor analysis and cluster analysis were applied on New York State public library systems’ 2008 annual reports to generate quantitative profiles of public library systems and their service transactions. Three cooperative public library systems displaying different service features were purposefully selected for further study of their service decision-making processes. The face-to-face and phone interviews were adopted in the study. Findings – Research findings from this study provide information on specific service variations across cooperative public library systems. The findings also provide differences of service decision-making processes in addition to the factors that might cause these differences. Originality/value – This study adds knowledge of public library systems’ management and organizational structures, therefore fills a knowledge gap on public library systems. It can also serve as the baseline for future studies using newer annual report data and therefore to study the changing roles and services of cooperative public library systems in New York State.
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Lu Meiling, Wu Youlu, and Zheng Guoxing. "Light and electron microscopic studies on red leg disease of the prawn (penaeus ortientalis kishinouye)." Proceedings, annual meeting, Electron Microscopy Society of America 48, no. 3 (August 12, 1990): 318–19. http://dx.doi.org/10.1017/s042482010015914x.
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The red leg disease of the prawn (Penaeus orientalis Kishinouye) is a new kind of disease which occurred and prevailed in many maricuiture farm in East China in recent years. The article reports the pathological changes in the microstructure of some tissues from the diseased prawn, which are studied by light microscopy (LM) and transmission electron micros copy(TEM). The result shows that small number of bacteria exist in the haemolymph of the diseased prawn and that the number of haemocytes decreases obviously. Lots of tree-like or radiation-like orange-red pigment granules are seen int the derma layer of the shell of the swimming feet by LM. In the ultrathin section of the swimming feet many parasitic bacteria can be observed assembling or scattering in the cytoplasm as well as in the cytoplasm of midgut, heart and gill fillarnents(Fig 4-6). Its proved that the bacteria separated from the haemlymph of the diseased prawn are the pathogen of the red leg disease known as Vibrio angullarum through the tests of the manual infection and bacteriological identifications. Its a short bacillus without germ, but with a single-ended flagella which has sheath.
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Burns, Shohei, Maya Vella, Alan Paciorek, Li Zhang, Chloe Evelyn Atreya, Eric Andrew Collisson, Mary Uan-Sian Feng, et al. "Characteristics and growth rate of lung metastases in patients with primary gastrointestinal malignancies: A retrospective cohort analysis." Journal of Clinical Oncology 39, no. 3_suppl (January 20, 2021): 442. http://dx.doi.org/10.1200/jco.2021.39.3_suppl.442.
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442 Background: There are no formal guidelines for the management of GI cancer pts with lung-exclusive or lung-predominant metastases (LM), which generally take a more indolent course than metastatic disease occurring at other anatomic sites. We performed a retrospective analysis at a high-volume tertiary care center to evaluate host and tumor characteristics of this pt population, describe treatment approaches, and model patterns and rates of growth. Methods: Eligible pts were identified through Cancer Center registry data, provider recall, and electronic record review. Criteria included LM occurring either synchronously (SLM) or metachronously (MLM) w/primary cancer diagnosis; nodal, but not visceral or peritoneal, mets allowed. Data re: demographics, tumor characteristics, and rx modalities were collected. We reviewed all eligible CT +/- PET scan reports to gather data on #, location, and size of pulm mets, with all images subsequently reviewed by an independent radiologist. Up to 5 pulm mets were tracked through each pt’s clinical course. Growth rate was estimated using a linear mixed model analysis considering patients as the random. Results: Forty pts were identified between 9/2009 - 12/2019 (23 F/17 M; 28 white/7 Asian/5 other/multi; median age 62 y.o.; n = 15 w/tobacco hx). Tumor types: pancreatic (n = 18), colorectal (n = 12), hepatobiliary (n = 7), other (n = 3). SLM vs MLM:13/27; intact vs resected primary = 16/24. Median time from orig cancer dx to onset of MLM = 16 mos (range, 1 to 60 mos). No. of pulm mets at 1st appearance: 1 (n = 7); 2-5 (n = 17); 6-10 (n = 16). Median size of largest pulm met at 1st appearance = 6 mm (range, 0-39 mm); avg growth rate of largest pulm met = 0.18 mm/month (95% CI, 0.08-0.27). Avg growth rate of up to 5 largest lesions (sum) = 0.35 mm/month (95% CI, 0.07-0.64). Median f/u time prior to rx initiation for MLM = 172 days (range, 25-1547 days); 18 pts developed additional mets during their observation period. Rx modalities for LM: surg (n = 6), radiation (n = 18), systemic rx (n = 32). Addn details specific to cancer type, progression patterns, and pt outcomes will be presented at the meeting. Conclusions: The natural hx of LM varies across the spectrum of GI malignancies. Further larger-scale efforts to define patterns of growth of LM for different GI cancers, informed by size, #, and clinical/molecular features, are needed to guide appropriate timing and selection of rx as well as surveillance strategies.
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Deepachandi, Bhagya, Sudath Weerasinghe, Samantha Ranasinghe, Thisira P. Andrahennadi, Mahendra N. Wickramanayake, Shantha Siri, Nadira Karunaweera, et al. "First Serological Study Revealing High Humoral Response and Evidence for Antigenic Heterogeneity in Leishmania donovani Induced CL in Sri Lanka." BioMed Research International 2020 (September 29, 2020): 1–11. http://dx.doi.org/10.1155/2020/5271657.
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Posing a threat to the ongoing leishmaniasis elimination efforts in the Indian subcontinent, L. donovani-induced cutaneous leishmaniasis (CL) has been recently reported in many countries. Sri Lanka reports a large focus of human cutaneous leishmaniasis (CL) caused by Leishmania donovani, a usually visceralizing parasite. Enhanced case detection, early treatment, and in-depth understanding of sequalae are required to contain the spread of disease. Visceralizing potential of dermotropic strains has not been fully ruled out. Sri Lankan strains have shown a poor response to established serological assays. The present concern was to develop an in-house serological assay and to determine the seroprevalence of CL for identifying visceralizing potential and its usefulness in enhancing case detection. Crude cell lysate of dermotropic L. donovani promastigotes-based indirect enzyme-linked immunosorbent assay (ELISA) was previously optimized. Assay was evaluated using sera from 200 CL patients, 50 endemic and 50 nonendemic healthy controls, 50 patients with other skin diseases, and 50 patients with other systemic diseases. Seroprevalence and clinicoepidemiological associations were analyzed. Assay was compared with light microscopy (LM) and in vitro culturing (IVC). Cost comparison was carried out. Seroprevalence of CL was 82.0%. The assay had 99.5% specificity, and all healthy controls were negative at 0.189 cut-off. Positive and negative predictive values were 99.4% and 84.7%, respectively. Positivity obtained in ELISA was comparable to LM and higher than that of IVC. Cost per patient was 3.0 USD for both ELISA and LM and 6.0 USD for IVC. Infections occurring in all age groups and both genders demonstrated >75.0% of seropositivity. Patients had lesions with different durations/types/sizes showed >70.0% of seropositivity. Study identified a high seroprevalence of L. donovani-induced CL for the first time, indicating potential for visceralization or transient serological response. This can be used as a second line test in LM-negative CL cases to enhance clinical case detection. Further studies are warranted to examine in-depth correlations, antigen profiles, comparison with other established serological tools, and usefulness in the detection of asymptomatic cases. (National patent LK/P/1/19697).
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Schnittger, Susanne, Frank Dicker, Wolfgang Kern, Torsten Haferlach, and Claudia Haferlach. "Cooperating Molecular Mutations in AML1/RUNX1 Mutated AML Differ Dependent on the Cytogenetic Subgroup." Blood 110, no. 11 (November 16, 2007): 365. http://dx.doi.org/10.1182/blood.v110.11.365.365.
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Abstract Certain mutations and chromosome aberrations have been shown to cooperate in AML leukemogenesis e.g. t(15;17) + FLT3 mutations, t(8;21) + KITD816 mutations, TP53 + complex aberrant karyotype. Previously AML1/RUNX1 mutations were associated with activating mutations e.g. in FLT3 and NRAS. We now performed a detailed analysis focused on distinct cytogenetic subgroups. A total of 120 selected AML with normal karyotype or recurrent aberrations were analyzed: normal karyotype (NK) (n=43); monosomy 7 (n=32), trisomy 8 (n=10), trisomy 13 (n=14), trisomy 21 (n=9), inv(3)/t(3;3) AML (n=12). Of these 105 were de novo, 7 had t-AML after previous chemotherapy (1 with NK, 4 with −7, 1 with +8, 1 inv(3)) and 8 had sAML after MDS (1 NK, 6 with −7, 1 with inv(3)). RUNX1 mutations were detected in cases with NK: 5/43 (11.6%); −7: 10/32 (31%); +8: 2/10 (20%); +13: 14/14 (100%); +21: 5/9 (55.6%), and inv(3)/t(3;3): 2/12 (12%). Thus, the subgroup with the highest RUNX1 mutation rate was +13 followed by +21. All cases were also analysed for FLT3-length mutations (FLT3-LM), FLT3-TKD mutations, MLL-PTD, NRAS, NPM1 and 38 in addition for CEBPA. NPM1mut and CEBPAmut were found to be nearly mutually exclusive of RUNX1mut. Further analysis was done for subgroups. NK subgroup: In 2 of 5 (40%) RUNX1mut AML with NK a FLT3-LM, in 2 a MLL-PTD, and 1 an NRAS mutation was detected. Thus within the 5 RUNXmut NK-AML a cooperating mutation was detected in all cases. −7 subgroup: No additional mutation was detected in the 10 RUNX1mut cases with −7. In contrast in RUNX1 unmutated cases (RUNX1wt) with −7 1/21 had FLT3-LM, 2/21 (9.5%) CEBPAmut, and 7/20 (35%) an NRASmut. + 8 subgroup: In 2 RUNXmut cases with +8 no further mutation was detected. In contrast 2 of the RUNXwt with +8 had an FLT3-LM, 3 a NPM1mut and 2 a NRASmut. +13 subgroup: All cases with +13 were RUNX1mut and 2/14 (14.3%) had a FLT3-LM and 1/14 (7.1%) a MLL-PTD. In this specific subgroup a 4-fold-elevated FLT3 expression was suggesting to be a specific cooperating event. +21 subgroup: All 5 RUNXmut with +21 had an additional aberration, 4 (80%) had FLT3-LM and 1 NPM1mut. Inv(3) subgroup: In both RUNX1mut inv(3) cases no additional mutation was found. In contrast 3/9 RUNX1wt cases with inv(3)/t(3;3) were NRAS mutated. Overall, additional mutations in RUNX1 mutated AML are very frequent in subgroups with NK and +21 (100%), unfrequent in +13 (21%) and absent in others (−7, +8, inv(3)/t(3;3)). In total (except +13, where no RUNX1wt cases were available), the frequency of additional mutations was higher in the RUNX1wtcases (41.6% vs. 87.8%) This is in contrast to previous reports that suggested that additional activating mutation in RUNX1mut AML are frequent. In contrast we found a high incidence of NRASmut in inv(3) (33%), −7 (35%), +8 (29%) and normal karyotype (14.3%) in cases with RUNX1wt. Monosomy 7 + RUNX1mut + NRASmut previously has been highly correlated to therapy related AML and AML after MDS. In our cohort with predominantely de novo AML we found a high correlation of RUNX1mut with −7 and a high correlation of −7 with NRAS, but no association of RUNX1mut with NRASmut. In addition, FLT3-LM has been highly correlated to AML1mut. We found this correlation only in cases with +21. In conclusion, FLT3-LM and NRAS mutations were detected as frequent cooperating mutations in RUNX1mut AML with NK and +21. No mutation cooperating with RUNXmut was detected in −7, +8, +13, and inv(3)/t(3;3). Here alternative mechanisms may drive leukemogenesis e.g. overexpression of FLT3 in +13 or dosage effects due to monosomies or trisomies.
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Okazaki, Yuki, Takayuki Furumatsu, Yuya Kodama, Yoshinori Matsumoto, Motoki Takahashi, and Toshifumi Ozaki. "Medial and Lateral Meniscus Posterior Root Tears with an Intact Anterior Cruciate Ligament." Case Reports in Orthopedics 2020 (July 18, 2020): 1–5. http://dx.doi.org/10.1155/2020/8842167.
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Background. Medial meniscus (MM) posterior root tear (PRT) is often caused by meniscal degeneration, whereas lateral meniscus (LM) PRT is mainly caused by trauma, especially trauma associated with anterior cruciate ligament (ACL) injuries. Although there are a few reports on PRTs of both menisci with an ACL injury, to our knowledge, there is no report on those with an intact ACL. Thus, the purpose of this study was to describe a rare case of both meniscal PRTs with an intact ACL. Case Presentation. A 67-year-old woman complained of right knee pain during weeding in a deep knee flexion position. At presentation, three days after the injury, physical examination revealed signs of meniscal injury without ACL rupture. Magnetic resonance imaging showed PRTs of both menisci and damaged cartilage, especially on the medial femoral condyle and lateral tibial plateau. MM was sutured using the FasT-Fix dependent modified Mason-Allen suture technique, and LM by a single simple stitch using the Knee Scorpion suture passer. Referring to previous cadaveric studies, transtibial pullout repair using a single tibial tunnel for MM fixation was performed. The stability of the repaired menisci was checked by probing during second-look arthroscopy at one year after the primary surgery, and no meniscal signs and symptoms were present at the last follow-up one year after the surgery. Conclusions. This rare case showed PRTs of both menisci with an intact ACL. We speculated that, in this case, both roots tore because of the degenerative menisci. A good clinical outcome was achieved after single-transtibial pullout repair. This technique may be an effective surgical approach for PRTs of both menisci.
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Byrne, Alex. "Possibility and imagination: a personal exploration of research and librarianship." Library Management 38, no. 1 (January 9, 2017): 11–19. http://dx.doi.org/10.1108/lm-08-2016-0065.
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Purpose Libraries and research have a symbiotic relationship. Researchers depend on libraries and the collections and information services we curate and libraries depend on researchers and writers, and their publishers, to deliver the stuff that we make available. The purpose of this paper is to explore the relationship between research and practice. Design/methodology/approach This paper reports the author’s perspective as a librarian with nearly four decades in practice who has undertaken a variety of research throughout his career. Findings Identifies the need for a more systematic relationship that will encourage better practice in research and lead practitioners to draw on the findings of more reliable research to inform their practice, test possibilities and stimulate imagination. Originality/value Tracing the intertwining of research and practice through one career, the paper presents a uniquely detailed perspective.
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Veeranjaneyulu, K. "KrishiKosh: an institutional repository of National Agricultural Research System in India." Library Management 35, no. 4/5 (June 3, 2014): 345–54. http://dx.doi.org/10.1108/lm-08-2013-0083.
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Purpose – The purpose of this paper is to provide online access to valuable resource, i.e., rare books, institutional publications, historical reports, theses, success stories, etc. to the researchers, teachers, extension specialists, farmers and scientists working in the ICAR institutes and state agricultural universities. Design/methodology/approach – Using open source software, the material in the repository was organized into institution-wise collection of documents such as books, journals, theses, reports, articles, etc. The process of digitization including scanning, cleaning, cropping, conversion to text (OCR), conversion to PDF/A, is currently being done at four different centres. So far, more than ten million pages from 19,495 documents have been digitized along with the necessary metadata. Findings – The “KrishiKosh” is a collaborative project which envisages launching an Indian agricultural knowledge portal over the internet and sharing its research information including Electronic Theses and Dissertations (ETD) with the rest of the world using latest information and communication technologies. Research limitations/implications – Users are able to access any information they want, from anywhere in the world, and at any time over the internet. It also culminated in launching of an Indian agricultural knowledge portal over the internet for sharing its research information including ETD with the rest of the world using the latest information and communication technologies. Practical implications – The agricultural research community will have access to the vast amount of rare and precious literature to further research and developments in agriculture and allied sectors to achieve self-sufficiency in food production. Social implications – While the population of the country is heading towards 1.23 billion, Indian agricultural scientists are engaged in increasing the food grain production to address the food security challenge. The importance of agricultural production in the context of global competition has occupied a significant place in the national development plan. It helps to provide right information, in right time at right place to increase the agriculture production. Originality/value – The Indian agricultural knowledge portal over the internet for sharing its research information including ETD among agriculture policy makers, scientists, etc. using latest ICT. The portal helps to avoid duplication and to acquire more resources to the agriculture knowledge centres.
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Wojciechowska, Maja Dorota. "The role of public libraries in the development of social capital in local communities – a theoretical study." Library Management 42, no. 3 (February 16, 2021): 184–96. http://dx.doi.org/10.1108/lm-10-2020-0139.
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PurposeSocial capital, understood as intangible community values available through a network of connections, is a factor in the development of societies and improving quality of life. It helps to remove economic inequalities and prevent poverty and social exclusion, stimulate social and regional development, civic attitudes and social engagement and build a civic society as well as local and regional identity. Many of these tasks may be implemented by libraries, which, apart from providing access to information, may also offer a number of services associated with social needs. The purpose of this paper is to present the roles and functions that libraries may serve in local communities in terms of assistance, integration and development based on classical social capital theories.Design/methodology/approachThe paper reviews the classical concepts of social capital in the context of libraries. It analyses the findings of Pierre-Félix Bourdieu, James Coleman, Francis Fukuyama, Robert Putnam, Nan Lin, Ronald Stuart Burt, Wayne Baker and Alejandro Portes. Based on their respective concepts, the paper analyses the role of the contemporary library in the social life of local communities. In particular, it focuses on the possible new functions that public libraries may serve.FindingsA critical review of the concept of social capital revealed certain dependencies between libraries and their neighbourhoods. With new services that respond to the actual social needs, libraries may serve as a keystone, namely they may integrate, animate and engage local communities. This, however, requires a certain approach to be adopted by the personnel and governing authorities as well as infrastructure and tangible resources.Originality/valueThe social engagement of libraries is usually described from the practical perspective (reports on the services provided) or in the context of research on the impact of respective projects on specific groups of users (research reports). A broader approach, based on original social theories, is rarely encountered. The paper draws on classical concepts of social capital and is a contribution to the discussion on possible uses of those concepts based on an analysis of the role of libraries in social life and in strengthening the social capital of local communities.
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Gao, Donghong, Alvaro Mendoza, Shijun Lu, and David A. Lawrence. "Immunomodulatory Effects of Danshen (Salvia miltiorrhiza) in BALB/c Mice." ISRN Inflammation 2012 (October 16, 2012): 1–13. http://dx.doi.org/10.5402/2012/954032.
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Danshen, the root and rhizome of Salvia miltiorrhiza Bge, a Traditional Chinese Medicine, especially for cardiovascular and cerebrovascular diseases, has unique immunomodulatory effects. Danshen is capable of anti-inflammation and antiallergy, which are immunosuppressive activities, whereas it is also able to promote immunity against cancer, viruses, and bacteria. Most previous reports were performed with use of a purified compound or compounds of Danshen. Since there are more than twenty active compounds in Danshen, it is very difficult to predict that one compound will act the same way when it is combined with other compounds. In order to overcome this limitation, we used the crude form of Danshen to study its immunomodulatory effects in a mouse model. The mice were fed daily diet supplements of Danshen for three months and then tested for their immunity, including leukocyte subsets in peripheral blood, humoral and cell-mediated immune responses, and host defenses against a Listeria monocytogenes (LM) infection. Different doses of Danshen caused different immunomodulatory effects. Danshen at 0.5% decreased serum IgE production in BALB/c mice; 1% Danshen promoted cell-mediated immunity; Danshen at 0.5 and 1% inhibited the production of oxygen free radicals in liver and spleen and NO production in liver; 2% Danshen enhanced the host resistance against LM with increased numbers of peripheral monocytes and natural killer (NK) cells and decreased production of IL-1β and NO.
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Riaux-Gobin, Catherine, PIERRE COMPÈRE, OSCAR E. ROMERO, and DAVID M. WILLIAMS. "Cocconeis pinnata W. Gregory ex Greville (Bacillariophyta): Lectotypification and an emended description after examination of type material and South Pacific specimens." Phytotaxa 156, no. 3 (January 16, 2014): 81. http://dx.doi.org/10.11646/phytotaxa.156.3.1.
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A marine species of Cocconeis (Bacillariophyta) from coral reef lagoon of Tahiti Island (Society Archipelago, South Pacific) was identified as Cocconeis pinnata W. Gregory ex Greville. Neither drawings nor micrographs of the raphe valve (RV) of C. pinnata are available in the literature. The examination of Gregory's type material (several slides annotated 'Arran 57' from Greville's collection housed in BM, British Museum, London, U.K.) allowed us to complete and emend the C. pinnata description. Lectotypification of C. pinnata is proposed. Since the raw material used by Gregory was not found, no scanning electron microscope (SEM) observation of type material can be provided. Except for Hustedt (1933) and a few later reports, all descriptions and illustrations agree with the original description. LM and SEM observations demonstrate that the sternum valve (SV) stria arrangement of specimens from Tahiti match those of the type. The description of the RV by Grunow in Van Heurck (1880) refers to a stria pattern very similar to that of C. pseudomarginata W. Gregory. The RV of C. pinnata, as revealed in LM and SEM, has a dense striation and no internal marginal rim. Both valves of C. pinnata have areolae with remarkable arborescent volae, which is a new feature for Cocconeis. Cocconeis pinnata is cosmopolitan, from cold-temperate to tropical areas. Several taxa have been formerly assigned to C. pinnata, though they are probably varieties of C. costata.
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Nawn, Debaleena, Saunak Chatterjee, Anji Anura, Swarnendu Bag, Debjani Chakraborty, Mousumi Pal, Ranjan Rashmi Paul, and Jyotirmoy Chatterjee. "Elucidation of Differential Nano-Textural Attributes for Normal Oral Mucosa and Pre-Cancer." Microscopy and Microanalysis 25, no. 05 (September 17, 2019): 1224–33. http://dx.doi.org/10.1017/s1431927619014867.
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AbstractComputational analysis on altered micro-nano-textural attributes of the oral mucosa may provide precise diagnostic information about oral potentially malignant disorders (OPMDs) instead of an existing handful of qualitative reports. This study evaluated micro-nano-textural features of oral epithelium from scanning electron microscopic (SEM) images and the sub-epithelial connective tissue from light microscopic (LM) and atomic force microscopic (AFM) images for normal and OPMD (namely oral sub-mucous fibrosis, i.e., OSF). Objective textural descriptors, namely discrete wavelet transform, gray-level co-occurrence matrix (GLCM), and local binary pattern (LBP), were extracted and fed to standard classifiers. Best classification accuracy of 87.28 and 93.21%; sensitivity of 93 and 96%; specificity of 80 and 91% were achieved, respectively, for SEM and AFM. In the study groups, SEM analysis showed a significant (p < 0.01) variation for all the considered textural descriptors, while for AFM, a remarkable alteration (p < 0.01) was only found in GLCM and LBP. Interestingly, sub-epithelial collagen nanoscale and microscale textural information from AFM and LM images, respectively, were complementary, namely microlevel contrast was more in normal (0.251) than OSF (0.193), while nanolevel contrast was more in OSF (0.283) than normal (0.204). This work, thus, illustrated differential micro-nano-textural attributes for oral epithelium and sub-epithelium to distinguish OPMD precisely and may be contributory in early cancer diagnostics.
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Morales, Eduardo A., Carlos E. Wetzel, Sinziana F. Rivera, Bart Van De Vijver, and Luc Ector. "Current taxonomic studies on the diatom flora (Bacillariophyceae) of the Bolivian Altiplano, South America, with possible consequences for palaeoecological assessments." Journal of Micropalaeontology 33, no. 2 (September 1, 2014): 121–29. http://dx.doi.org/10.1144/jmpaleo2014-007.
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Abstract. The present investigation is based on detailed taxonomical analyses combining light microscopy (LM), scanning electron microscopy (SEM) and critical reviews of publications and type material. This method revealed a higher number of diatom taxa than that reported for the Altiplano, reports that are based on LM and SEM, but force-fitting the taxa into their European relatives. It also became evident that some taxa often reported from the Altiplano do not occur or are less common in this region and that misidentifications are the consequence not only of force-fitting, but also of misinterpretation of the original protologues and illustrations (taxonomic concept drift). These findings have important repercussions on past palaeoecological assessments for the Altiplano, which have been based on ecological information for taxa developing in ecosystems of highly contrasting conditions. Here we present the case of three araphid diatoms, which were reported as known taxa from Europe and elsewhere, but in fact correspond to taxa described as new for the Altiplano or unpublished taxa. It is recommended that: (1) a flora for this region is developed utilizing sound microscopical data and reviewing pertinent type material, (2) key common taxa used for past palaeoecological studies in the Altiplano are reviewed using a taxonomically thorough and critical method, and (3) future palaeoecological studies for the Andes are supported by prior detailed taxonomical analysis.
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Stephens, Michael. "23 Mobile Things: self-directed and effective professional learning." Library Management 35, no. 8/9 (November 10, 2014): 582–93. http://dx.doi.org/10.1108/lm-02-2014-0034.
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Purpose – The purpose of this paper is to examine the “Mobile 23 Things” survey results from the program offered by Guldborgsund-bibliotekerne (a public library in Denmark) and present the findings as support for professional development (PD) models to increase library staff familiarity with emerging technologies. Design/methodology/approach – Using an integrated, exploratory approach, a web-based survey tool, developed for a previous Learning 2.0 study, was adapted for this study, with survey questions translated English – Danish, and responses Danish – English. The data gathered from both pre- and post-program surveys are presented and analyzed. Findings – The research results identify that 23 Mobile Things increases familiarity with movable technologies, promotes inclusive learning, and can be an effective model for delivering PD. Originality/value – This paper reports on the first research study to evaluate the 23 Mobile Things model and provides evidence that this model of library staff PD can be an overall beneficial experience that increases staff knowledge and expertise related to mobile devices and applications.
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Alajmi, Bibi. "When the Nation is in crisis: libraries respond." Library Management 37, no. 8/9 (November 14, 2016): 465–81. http://dx.doi.org/10.1108/lm-05-2016-0043.
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Purpose The purpose of this paper is to shed light on the role of libraries as community institutions by reflecting on the experience of the Ferguson Municipal Public Library (FMPL), Missouri, USA, during the time of social unrest in the summer of 2014. The research explores the traditional and non-traditional roles of libraries during times of social unrest while focusing on relevant areas of crisis management preparedness and competencies necessary during crisis. Design/methodology/approach The study adopts a qualitative approach in investigating the research problem and uses the case study method to collect relevant data. Findings This paper reports on the experience of the FMPL staff during this time. Their experience of what happened, how they dealt with it, and what their expectations were after the crisis are all documented. Originality/value Several scholars have studied how public libraries respond to disasters, yet little is known about whether public libraries proactively engage in community-wide disaster planning, and if so, what is the nature of those partnerships.
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YILMAZ ÇITAK, BURCU. "A palynological survey of the genus Iberis (Brassicaceae), known as candytufts, in Turkey." Phytotaxa 397, no. 3 (March 19, 2019): 213. http://dx.doi.org/10.11646/phytotaxa.397.3.1.
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The present study reports for the first time detailed palynological traits of the Turkish species Iberis. Both light microscope (LM) and scanning electron microscope (SEM) were used for the characterisation of the species. Radially symmetrical, isopolar, and tricolpate pollen grains were observed as common characters in all of the examined taxa. The pollen grains were prolate-spheroidal with polar axes ranging from 21.97 to 29.25 µm and equatorial axes ranging from 20.34 to 26.09 µm. Their polar shapes were subcircular to subtriangular. Two types of exine ornamentation were observed using a SEM. A numerical UPGMA analysis showed that the dimensions of polar axes, equatorial axes and outline in polar view (amb) were the most valuable variables for separating the Iberis species.
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Kim, Rathana, Myrto Costopoulos, Sylvain Choquet, Karim Maloum, Caroline Algrin, Khe Hoang-Xuan, Catherine Settegrana, et al. "To Dose or Not to Dose: Are IL-10 and IL-6 Accurate Biomarkers to Detect Leptomeningeal Involvement in Small B-Cell Lymphoproliferation?" Blood 126, no. 23 (December 3, 2015): 3878. http://dx.doi.org/10.1182/blood.v126.23.3878.3878.
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Abstract Identifying the etiology of neurological symptoms in hematological malignancies is still a challenging issue. Lymphomatous meningitis (LM) is mainly described in aggressive systemic B-cell lymphomas (diffuse large B-cell (DLBCL) and Burkitt lymphomas), and is associated with poor prognosis. Leptomeningeal involvement in small B-cell lymphoproliferation is a rare, poorly described condition, mentioned only in case reports. The diagnosis relies on the combination of non-specific central nervous system (CNS) symptoms (headaches, paraplegia, etc.) or psychiatric symptoms, and the cytological detection of tumor cells in the cerebrospinal fluid (CSF). However, cell analysis has a low sensitivity here due to the small drawn volumes of CSF samples, their poor cellularity and cell viability. Soluble biomarkers can be measured by multiplex techniques on small sample volumes, hence can overcome cytological limitations and seem fairly interesting for further investigations. The aim of the present study was to evaluate the diagnostic value of interleukin (IL)-10 and IL-6 quantification combined with the IL-10:IL-6 ratio in CSF of patients suffering from LM secondary to systemic small B-cell lymphoproliferations. Seventeen patients suffering from LM were included in the study: 4 with chronic lymphocytic leukemia (CLL), 2 with mantle-cell lymphoma (MCL) and 11 with Waldenström's macroglobulinemia (WM). All patients presented CNS symptoms associated with documented LM (revealed either by conventional cytology and/or flow cytometry) at the diagnostic stage and before intrathecal chemotherapy. IL-10 and IL-6 quantifications were performed in CSF using the quantitative Cytometric Bead Array® technique (human IL-10 CBA kit and human IL-6 CBA kit; BD BiosciencesTM) on a FACSCanto II flow cytometer (BD BiosciencesTM) following the manufacturer's recommendations, with a limit of detection of 2.5 pg/ml. All CLL and MCL patients displayed an undetectable level of IL-10 (<2.5 pg/ml) along with undetectable (<2.5 pg/ml) or low level of IL-6 (n=6; range <2.5-14 pg/ml) in the CSF. These results suggest that IL-10 and IL-6 are not increased in secondary LM in these two malignancies. WM patients had a more heterogeneous distribution and are divided into 2 groups: undetectable IL-10 (n=4) or positive IL-10 (n=7; range 4-39 pg/ml with a median value of 18 pg/ml). We therefore calculated the IL-10:IL-6 ratio in this group, setting the threshold at 1 as firstly described in primary vitroretinal lymphomas and more recently in primary central nervous system lymphoma (PCNSL). Two patients displayed a ratio >1; one had WM transformed into DLBCL in CNS (IL-10= 21pg/ml; IL-6= 7pg/ml; IL-10:IL-6= 3), and the other had a PCNSL simultaneously diagnosed in CSF (IL-10= 18pg/ml; IL-6= 4pg/ml; IL-10:IL-6= 4.5). Other patients with a ratio <1 have a documented Bing Neel syndrome (BNS) and an absence of any other aggressive B-cell lymphoma. Furthermore, IL-6 levels were higher in CSF of BNS patients (n=9; range 4-540 pg/ml with a median value of 32 pg/ml) than in CLL and MCL patients. Our findings demonstrate the need of IL-10 and IL-6 quantification with the use of IL-10:IL-6 ratio at diagnosis of LM in small B-cell lymphoproliferations to exclude any other aggressive B-cell malignancy. Further investigation of IL-6 concentration may be useful in BNS diagnosis regardless of the ratio because some data demonstrate a central role of IL-6 in WM pathophysiology. Besides, it has already been reported that CCL5 production by tumor microenvironment in WM leads to IL-6 and IgM secretion through the JAK/STAT signaling pathway. In conclusion, we describe for the first time that IL-10 concentration in the CSF is not increased in small B-cell lymphoproliferations with LM. However, we report its usefulness in revealing more aggressive lymphomas in the context of either a transformation or when associated with another "hidden" lymphoma such as PCNSL. Supplementary data will be prospectively collected to confirm our preliminary results. On one hand, it seems important to study CLL cases with or without Richter syndrome, and on the other hand to further explore the role of IL-6 in BNS. Disclosures Choquet: Roche: Consultancy; Janssen: Consultancy. Leblond:Gilead: Consultancy, Honoraria, Speakers Bureau; Roche: Consultancy, Honoraria, Other: Travel, Accommodations, Expenses, Speakers Bureau; Mundipharma: Honoraria; Janssen: Consultancy, Honoraria, Speakers Bureau; GSK: Consultancy, Honoraria, Speakers Bureau.
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Chiware, Elisha R. T. "Open research data in African academic and research libraries: a literature analysis." Library Management 41, no. 6/7 (June 1, 2020): 383–99. http://dx.doi.org/10.1108/lm-02-2020-0027.
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PurposeThe paper presents a literature review on research data management services in African academic and research libraries on the backdrop of the advancing open science and open research data infrastructures. It provides areas of focus for library to support open research data.Design/methodology/approachThe literature analysis and future role of African libraries in research data management services were based on three areas as follows:open science, research infrastructures and open data infrastructures. Focussed literature searches were conducted across several electronic databases and discovery platforms, and a qualitative content analysis approach was used to explore the themes based on a coded list.FindingsThe review reports of an environment where open science in Africa is still at developmental stages. Research infrastructures face funding and technical challenges. Data management services are in formative stages with progress reported in a few countries where open science and research data management policies have emerged, cyber and data infrastructures are being developed and limited data librarianship courses are being taught.Originality/valueThe role of the academic and research libraries in Africa remains important in higher education and the national systems of research and innovation. Libraries should continue to align with institutional and national trends in response to the provision of data management services and as partners in the development of research infrastructures.
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Deodhar, Madhura, and Sushama Powdwal. "Impact of continuing education programs (CEPs) on LIS professionals in academic libraries in Mumbai, India." Library Management 38, no. 2/3 (March 14, 2017): 117–30. http://dx.doi.org/10.1108/lm-07-2016-0051.
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Purpose The purpose of this paper is to report the research findings of an evaluation of the impact of continuing education programs (CEPs) on library information science (LIS) professionals of academic libraries in Mumbai, India. The paper also introduces Donald Kirkpatrick model of training evaluation for Library Science research in the area of program evaluation. Design/methodology/approach The impact of CEPs was evaluated using Donald Kirkpatrick model of training evaluation using survey method. The impact was evaluated at four levels; reaction, learning, behavior and results. The population of the present study included 344 LIS professionals working at colleges libraries affiliated to University of Mumbai and Shreemati Nathibai Damodar Thackersey (SNDT) Women’s University in Mumbai, India. The data collected through questionnaire were supplemented by five specimen interviews of heads of institutions of the academic librarians who had attended more than five CEPs in five years, 2009-2013. Findings The findings of the study revealed that professionals were satisfied with CEP attendance; keen on gaining more knowledge and transferring the acquired knowledge and skills at their workplaces and interested in implementing the learning to achieve results. The reasons given by academic librarians on not implementing the learning in the library indicated that there were hindrances like lack of management support, lack of technical expertise, inadequate staff in the library, poor IT Infrastructure, etc. in transferring the learning at work. Research limitations/implications The study was based on self-perceptions of respondents. The limitation of self-perception was eliminated to some extent by supplementing qualitative data wherever required. CEPs included conferences, seminars, workshops, refresher courses, orientation programs and online courses. Pre-test and post-test recommended by the Kirkpatrick model could not be conducted as the researcher has not adopted experimental design. The data of feedback from the organizers and content of the CEPs attended by respondents were not analyzed in the study. Practical implications The paper describes the implementation of Kirkpatrick model to evaluate the CEPs, which can be used by the organizers or institutions to evaluate the impact of CEPs in future. This will help them to improve upon the contents of CEPs making them more relevant and effective. Social implications Evaluation of CEPs will be useful to ensure the effectiveness of CEPs and performance of LIS professionals. Originality/value This paper reports an original research initiative undertaken to evaluate the impact of CEPs attended by LIS professionals of Indian academic libraries in Mumbai, India. It fills the gap in LIS research. The application of Donald Kirkpatrick model of Training evaluation is also valuable for LIS research.
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Fuehles-Ubach, Simone. "What is your contribution to the funder’s strategy?" Library Management 39, no. 3/4 (June 11, 2018): 146–53. http://dx.doi.org/10.1108/lm-10-2017-0112.
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Purpose The purpose of this paper is to describe the different positions and roles that German research libraries may have in their funding organizations: center or periphery, making a change with respect to the overall strategy or having just a strategy of their own; having strong communication links to the top management or just to their users. Design/methodology/approach Since 2008, the Joint Science Conference (Gemeinsame Wissenschaftskonferenz (GWK)) in Germany deals with all questions of research funding, science and research policy strategies and the science system which jointly affect the Federal Government and the Länder. For the big four German national research societies (Max-Planck, Helmhold, Fraunhofer, Leibnitz), the GWK formulated a set of performance indicators that are used to compare the different societies in a monitoring report published every year. Interestingly, there are several aspects affecting the libraries and their services and products, but the performance of the libraries (approximately 200) is not clearly mentioned. Findings An exemplary matrix is developed that can be adapted by all research libraries to show to which extent the research library is able to support and influence the level of different performance indicators and thereby to contribute to the overall goal of the organization. A graduated traffic light system is used to highlight which contributions in which areas can be expected from the research library. Research limitations/implications Research libraries are usually quite different from each other and there are not many tools to compare their contributions and to show their performance to the management level. In this paper, a method to show the influence and impact in the German research context is used, which may not be applicable to other countries with other research structures. Practical implications The paper identifies the importance of playing an essential role in the fulfillment of the overall strategic goals of the funding organization, especially for research libraries as there are usually special metrics to compare the big scientific research organizations in Germany. Social implications It is shown that there are simple ways to derive strategic goals and key figures and translate them into a benchmark and even use existing reports and systems. Originality/value The value of research libraries has usually been seen as supporting the research process for the users in the best possible way. As more competition arises between different research institutions or societies, the role of the library with respect to the contribution to the stakeholder’s strategy opens up another perspective.
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Ortenzi, Marco Aldo, Stefano Antenucci, Stefania Marzorati, Lucia Panzella, Silvia Molino, José Ángel Rufián-Henares, Alessandra Napolitano, and Luisella Verotta. "Pectin-Based Formulations for Controlled Release of an Ellagic Acid Salt with High Solubility Profile in Physiological Media." Molecules 26, no. 2 (January 15, 2021): 433. http://dx.doi.org/10.3390/molecules26020433.
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Among bioactive phytochemicals, ellagic acid (EA) is one of the most controversial because its high antioxidant and cancer-preventing effects are strongly inhibited by low gastrointestinal absorption and rapid excretion. Strategies toward an increase of solubility in water and bioavailability, while preserving its structural integrity and warranting its controlled release at the physiological targets, are therefore largely pursued. In this work, EA lysine salt at 1:4 molar ratio (EALYS), exhibiting a more than 400 times increase of water solubility with respect to literature reports, was incorporated at 10% in low methoxylated (LM) and high methoxylated (HM) pectin films. The release of EA in PBS at pH 7.4 from both film preparations was comparable and reached 15% of the loaded compound over 2 h. Under simulated gastric conditions, release of EA from HM and LM pectin films was minimal at gastric pH, whereas higher concentrations—up to 300 μM, corresponding to ca. 50% of the overall content—were obtained in the case of the HM pectin film after 2 h incubation at the slightly alkaline pH of small intestine environment, with the enzyme and bile salt components enhancing the release. EALYS pectin films showed a good prebiotic activity as evaluated by determination of short chain fatty acids (SCFAs) levels following microbial fermentation, with a low but significant increase of the effects produced by the pectins themselves. Overall, these results highlight pectin films loaded with EALYS salt as a promising formulation to improve administration and controlled release of the compound.
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Kaba, Abdoulaye. "Online library job advertisement in United Arab Emirates: a content analysis of online sources." Library Management 38, no. 2/3 (March 14, 2017): 131–41. http://dx.doi.org/10.1108/lm-07-2016-0058.
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Purpose The purpose of this paper is to investigate and analyze library jobs advertised by higher education institutions, newspapers and job market sites in United Arab Emirates (UAE). Design/methodology/approach The paper uses summative content analysis approach for data collection, data analysis, evaluation and assessment. It reports about the accuracy of advertisements, job titles, job categories, locations and types of libraries. Findings Higher education institutions demonstrate the highest accuracy level in advertising library jobs. Librarian emerged to be the highest advertised title by the sources. e-library executive, principal-publications and library, and primary librarian found to be the new titles in the market. The paper also found inconsistencies and lack of uniformities among the sources in using job categories to advertise library jobs. In fact, none of them used the term “library” in any category. Academic libraries recorded the highest advertised jobs compared to other types of libraries. Research limitations/implications The paper is based on library jobs advertised on the websites. Websites are only one source of library job advertisement. Practical implications The paper provides important information for librarians looking for library jobs in the Middle East as well as for library managers and decision makers who wish to recruit library professionals. Originality/value The paper represents one of the few studies conducted on library job marketing in UAE. Findings of the study may contribute to the improvement of library job marketing not only in UAE but also in the other gulf countries.
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Ismayilov, Khalil, Nadir Ismayilov, and Vafa Mammadova. "Library information services in academic libraries of Azerbaijan: a comparative study." Library Management 40, no. 6/7 (August 12, 2019): 461–77. http://dx.doi.org/10.1108/lm-08-2018-0069.
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Purpose The purpose of this paper is to comparatively study the library and information services provided by three academic libraries – Baku State University Scientific Library, ADA University Library and Information Services and Khazar University Library and Information Center – located in Baku, Azerbaijan. Various types of library services are examined in terms of funding, acquisition and technical equipment support issues. Also, different subordination conditions (public/private) of the universities help to better understand the current position of academic libraries in different entities. Design/methodology/approach Most part of the conveyed information was obtained through review of related literature, libraries’ annual reports and personal communication with the directors of the academic libraries, to look for similarities and differences in provided library and information services. The results of the study are comparatively described through multiple tables and charts. Findings For improving services it is necessary to develop paid forms of library and information services, maintain various training possibilities for library staff in modern librarianship areas, increase the variety and number of public and outreach activities. Research limitations/implications As the findings of the paper suggest new forms of library services and activities, it is necessary to continue the topic in further studies to develop practical methods and applications for local library conditions. Originality/value The paper can be accepted as the first comparative study of the library information services in academic libraries of Azerbaijan, which gives general overview and analysis of separate service ranges and types. The researchers interested in Azerbaijani librarianship may find it practical.
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Corrall, Sheila. "Capturing the contribution of subject librarians." Library Management 36, no. 3 (March 9, 2015): 223–34. http://dx.doi.org/10.1108/lm-09-2014-0101.
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Purpose – The strategic contribution of subject librarians as information specialists in the digital world has been questioned by institutional administrators, but others have identified expanded roles and new opportunities in learning and research support. The purpose of this paper is to investigate the application of Kaplan and Norton’s strategic management system of balanced scorecards and strategy maps to subject librarianship in universities, with particular reference to the intellectual capital represented and created in the structures, relationships, and know-how of liaison work. Design/methodology/approach – A literature review was used to define established and emergent roles, responsibilities and skillsets of subject librarians, including their reach beyond the library. A web site survey investigated goals, actions, and values related to liaison work in UK library strategies. Data were analyzed thematically to develop an exemplar map and assess its potential for evaluating the contribution of subject librarians. Findings – Core functions continue, with expanded scope and competencies. Collaboration and integrated services are key trends for mapping. Liaison work is poorly documented in existing strategies. Preliminary results suggest that strategy maps can be used to illustrate the strategic contribution of subject librarians. Research limitations/implications – The paper reports the early stages of a multi-phase project. The results are limited to the conceptual phase. The next phase will explore the development of both maps and balanced scorecards via case studies in different countries. Originality/value – There are few examples of library applications of strategy maps and balanced scorecards at unit or program level, and none with a focus on the intangible assets of subject librarians.
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Kaba, Abdoulaye. "Library employment." Library Management 38, no. 8/9 (November 14, 2017): 511–27. http://dx.doi.org/10.1108/lm-03-2017-0036.
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Purpose The purpose of this paper is to investigate the library employment in UAE and explore the perceptions of academic librarians toward job satisfaction, employment opportunities, employment challenges, and future actions needed to improve employment opportunities for librarians in UAE. Design/methodology/approach Data were collected through an online survey questionnaire. A total of 62 academic librarians from public and private universities and colleges participated in the study. The collected data are analyzed to answer research questions and verify the hypotheses. Findings Respondents expressed high satisfaction with salary and benefits, job positions, responsibilities given to them, and appreciations from senior management. However, they are found unsatisfied with promotion policies and employment opportunity. They reported challenges for getting jobs and expressed concerns about the future of librarians in UAE. With the exception of experience, findings of the study show no significant difference of demographic factors on job satisfaction, the perceived employment opportunity, and challenges. Majority of participants believe that employment opportunity for librarians can be improved through IT courses, promotion policies, training, career structure, marketing, and changing school name. They agree that reducing the number of students will not improve employment opportunities for librarians. Research limitations/implications This is a descriptive study based on a survey questionnaire. Future studies may use qualitative methods such as the interview for more exploration and in-depth analysis. Practical implications The findings provide concerns about the future of librarianship in UAE and appeal to library educators, managers, and decision makers to improve employment opportunities for librarians. Originality/value The paper reports original research findings on job satisfaction, employment opportunities, employment challenges, and future actions as perceived by academic librarians in UAE.