Relevant bibliographies by topics / LNCaP cell line

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Academic literature on the topic 'LNCaP cell line'

Author: Grafiati
Published: 2 June 2025
Last updated: 31 July 2025

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Journal articles on the topic "LNCaP cell line"

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Yanish, Yu V., M. P. Prylutskyi, I. O. Sumnikova, et al. "THE INFLUENCE OF SPERMINE AND CHLORHEXIDINE ON THE SURVIVAL, ELECTROKINETIC AND CYTOMORPHOLOGICAL CHARACTERISTICS OF HUMAN PROSTATE CANCER CELLS." Oncology 25, no. 3 (2023): 186–93. http://dx.doi.org/10.15407/oncology.2023.03.186.

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Summary. Aim: to study the effects of spermine and the spermine oxidase inhibitor chlorhexidine, applied alone or in combination, on the viability, electrokinetic and structural-functional characteristics of human prostate cancer cells in vitro. Object and methods: Studies were conducted on cell cultures: differentiated androgen-dependent LNCaP cell line and low-differentiated androgen-independent DU-145 cell line. Cell survival was determined by the method of exclusion of the vital dye trypan blue by living cells. The electrokinetic parameters of the cells (ζ-potential and total surface charg
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Kim, Sang Soo, Hee Joo Cho, Jung Yoon Kang, Hee Kyu Kang, and Tag Keun Yoo. "Inhibition of Androgen Receptor Expression with Small Interfering RNA Enhances Cancer Cell Apoptosis by Suppressing Survival Factors in Androgen Insensitive, Late Stage LNCaP Cells." Scientific World Journal 2013 (2013): 1–8. http://dx.doi.org/10.1155/2013/519397.

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Introduction.The aim was to evaluate the changes of androgen receptor (AR) expression quantitatively and to identify influence of AR on cancer related survival markers in LNCap cell line.Materials and Methods. We compared expressions of AR, heat shock protein 27 (HSP27), clusterin (CLU), glucose-related protein 78 (GRP78), and cellular FLICE-like inhibitory protein (c-FLIP) and their genes between es-LNCaP (less than 33 times subcultured, L-33), ls-LNCaP (over 81 times subcultured, H-81), and si-LNCaP (AR siRNA transfected ls-LNCaP) by Western blotting and RT-PCR.Results. The expressions of AR
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Lima, Thiago S., Diego Iglesias-Gato, Luciano D. O. Souza, et al. "Molecular Profiling of Docetaxel-Resistant Prostate Cancer Cells Identifies Multiple Mechanisms of Therapeutic Resistance." Cancers 13, no. 6 (2021): 1290. http://dx.doi.org/10.3390/cancers13061290.

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Docetaxel—a taxane-based chemotherapeutic agent—was the first treatment to demonstrate significant improvements in overall survival in men with metastatic castration-resistant prostate cancer (mCRPC). However, the response to docetaxel is generally short-lived, and relapse eventually occurs due to the development of resistance. To explore the mechanisms of acquired docetaxel resistance in prostate cancer (PCa) and set these in the context of androgen deprivation therapy, we established docetaxel-resistant PCa cell lines, derived from the androgen-dependent LNCaP cell line, and from the LNCaP l
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Guillemette, Chantal, and Alain Bélanger. "Glucuronosyltransferase activity in human cancer cell line LNCaP." Molecular and Cellular Endocrinology 107, no. 2 (1995): 131–39. http://dx.doi.org/10.1016/0303-7207(94)03434-u.

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Ruokonen, Minna, Jing-Dong Shan, Pirjo Hedberg, Lila Patrikainen, and Pirkko Vihko. "Transfecting Well-Differentiated Prostatic Cancer Cell Line LNCaP." Biochemical and Biophysical Research Communications 218, no. 3 (1996): 794–96. http://dx.doi.org/10.1006/bbrc.1996.0141.

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Seki, Taiga, Yui Shimizu, Kyota Ishii, Yuzuki Takahama, Kazunori Kato, and Tomohiro Yano. "NK Cells Can Preferentially Target Prostate Cancer Stem-like Cells via the TRAIL/DR5 Signaling Pathway." Biomolecules 11, no. 11 (2021): 1702. http://dx.doi.org/10.3390/biom11111702.

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Background: The occurrence of androgen-dependent prostate cancer mainly depends on prostate cancer stem cells. To reduce the risk of androgen-dependent prostate cancer, the direct elimination of prostate cancer stem cells is important, but an elimination strategy has not yet been established. A previous study showed that natural killer (NK) cells can preferentially target cancer stem cells in several solid tumors except prostate cancer. In this context, this study was undertaken to investigate if NK cells can selectively attack androgen-dependent prostate cancer stem cells. Methods: Prostate c
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Yanish, Yu V., M. P. Prylutskyi, O. K. Voronina, and S. P. Zaletok. "THE INFLUENCE OF SPERMINE AND AMINOGUANIDINE ON THE MORPHOFUNCTIONAL CHARACTERISTICS OF HUMAN PROSTATE CANCER CELL LINE LNCaP." Oncology 25, no. 1 (2023): 24–31. http://dx.doi.org/10.15407/oncology.2023.01.024.

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Summary. Aim: to investigate the inhibitory effect of spermine (Spn) and the modifying effect of aminoguanidine (AG) on the structural and functional characteristics of human prostate cancer cells of the LNCaP line, depending on the mode of their use. Object and methods: studies were conducted in vitro on human prostate cancer (PC) cells of the hormone-dependent LNCaP line. Cell survival was determined by the trypan blue exclusion. The concentration of Spn used in the study was 1.5 and 5.0 mM, and AG in combination with Spn 1.5 mM. Changes in the morphology of LNCaP cells were evaluated under
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Kang, Minyong, Chang Wook Jeong, Kyoung-Hwa Lee, Ja Hyeon Ku, Hyeon Hoe Kim, and Cheol Kwak. "Histone demethylase KDM7a to control androgen receptor activity in hormone-sensitive prostate cancer." Journal of Clinical Oncology 35, no. 6_suppl (2017): 262. http://dx.doi.org/10.1200/jco.2017.35.6_suppl.262.

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262 Background: Prostate cancer can be controlled by androgen-hormone treatment until the cancer becomes refractory. It is believed that hormone sensitivity is largely dependent on androgen receptor (AR) activity. Here, we investigated the molecular mechanism whereby androgen receptor activity is regulated by histone demethylase KDM7a, which demethylates histone H3K9 and H3K27. Methods: The LNCaP, PC3, and DU145 cell lines were cultured at 37 °C in 5% CO2 in Minimum Essential Medium alpha, which was supplemented with 10% fetal bovine serum. We engineered AR-positive LNCaP cells to stably expre
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Mohtashami, Leila, Narjes Ghows, Zahra Tayarani-Najaran, and Mehrdad Iranshahi. "Galbanic Acid-Coated Fe3O4 Magnetic Nanoparticles with Enhanced Cytotoxicity to Prostate Cancer Cells." Planta Medica 85, no. 02 (2018): 169–78. http://dx.doi.org/10.1055/a-0721-1886.

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AbstractGalbanic acid is a natural sesquiterpene coumarin compound with different biological activities, particularly cytotoxicity against LNCaP (an androgen-dependent prostate cancer cell line). Galbanic acid induces apoptosis in LNCaP via down-regulation of androgen receptor. However, the poor water-solubility of galbanic acid limits further in vitro and in vivo studies. In this study we present the synthesis of galbanic acid-coated Fe3O4 magnetic nanoparticles and their cytotoxicity evaluation on three prostate cancer cell lines, including PC3 (an androgen-independent cell line), LNCaP, and
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Abate-Shen, Cory, and Francisca Nunes de Almeida. "Establishment of the LNCaP Cell Line – The Dawn of an Era for Prostate Cancer Research." Cancer Research 82, no. 9 (2022): 1689–91. http://dx.doi.org/10.1158/0008-5472.can-22-1065.

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Abstract Among the relatively few established human prostate cancer cell lines, LNCaP cells are unique in their ability to model key stages of prostate cancer progression. Analyses of LNCaP cells and their derivatives have been invaluable for elucidating important translational aspects of prostate tumorigenesis, metastasis, and drug response, particularly in the context of androgen receptor signaling. Here, we present major highlights from a wealth of literature that has exploited LNCaP cells and their derivatives to inform on prostate cancer progression and androgen response for improving the
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Dissertations / Theses on the topic "LNCaP cell line"

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Donthula, Vinitha Islam Naz E. "Effects of nano-second pulsed electric fields (nsPEF) on human prostate cancer cell line - LNCaP." Diss., Columbia, Mo. : University of Missouri--Columbia, 2008. http://hdl.handle.net/10355/5665.

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The entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract appears in the public.pdf file. Title from PDF of title page (University of Missouri--Columbia, viewed on September 22, 2009). Thesis advisor: Dr. Naz E. Islam. Includes bibliographical references.
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Grouf, Jaime L. "Characterization of value nutritions 5-androstenediol product and its proliferative effects on the LNCaP cell line." Link to electronic thesis, 2007. http://www.wpi.edu/Pubs/ETD/Available/etd-102707-170420/.

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Ito, Noriyuki. "Concomitant Presence of p16/Cyclin-dependent Kinase 4 and Cyclin D/Cyclin-dependent Kinase 4 Complexes in LNCaP Prostatic Cancer Cell Line." Kyoto University, 2000. http://hdl.handle.net/2433/151432.

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Israel, Karen E. "Growth arrest and apoptotic induction in RRR-[alpha]-tocopheryl succinate-treated LNCaP and PC-3 human prostate cancer cell lines /." Digital version accessible at:, 1999. http://wwwlib.umi.com/cr/utexas/main.

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Lynch, Jill Ellen. "Functional studies of SCN2B over-expression in LNCaP human prostate cancer cells." Access to citation, abstract and download form provided by ProQuest Information and Learning Company; downloadable PDF file, 103 p, 2008. http://proquest.umi.com/pqdweb?did=1481658511&sid=16&Fmt=2&clientId=8331&RQT=309&VName=PQD.

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MacDonald, Anne. "Studies of epidermal growth factors in prostate cancer using the cell lines DU 145 & LNCaP." Thesis, University of Edinburgh, 1990. http://hdl.handle.net/1842/19068.

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Epidermal growth factor (EGF) receptor expression and modulation of growth rate by EGF were investigated in the androgen insensitive Du 145 and androgen sensitive LNCaP prostatic carcinoma cell lines. Competition and saturation analysis of binding data revealed one high affinity binding site for both DU 145 (lnmol/l±0.6) and LNCaP (2.8nmol/l±2.2), with DU 145 cells expressing high levels of receptor binding sites/cell (2.5xlOs±lxl06) and LNCaP cells expressing 10 fold lower receptor binding sites/cell (2xl04±lxl04). Addition of exogenous EGF or TGFa to scrum free cultures of DU 145 cells only
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Okeke, Joy C. "The Effects of Ellagic Acid on Insulin-Like Growth Factor Binding Protein-2 in Human Prostate Cancer Cells." Bowling Green State University / OhioLINK, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1162343994.

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Msiska, Thomson. "An in vitro investigation of the effects of camellia sinensis and aspalathus linearis on benign (RPWE 1) and malignant (LNCaP) prostate cell lines." University of the Western Cape, 2015. http://hdl.handle.net/11394/5335.

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Magister Scientiae (Medical Bioscience) - MSc(MBS)<br>The prostate is prone to three pathological processes that include inflammation, benign prostate hyperplasia (BPH) and tumors. According to the center for Disease and Control 1999-2012 report, prostate cancer is the second leading cause of death in the United States. Scientific evidence suggests that up to 30% of men in the general population aged from 50 years and above, irrespective of geographic origin, have foci of prostate neoplastic growth. Unbalanced ROS production and a dysregulated antioxidant defence system have been implicated in
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Vaarala, M. (Markku). "Differential gene expression in prostate cancer:identification of genes expressed in prostate cancer, androgen-dependent and androgen-independent LNCaP cell lines, and characterization of TMPRSS2 expression." Doctoral thesis, University of Oulu, 2000. http://urn.fi/urn:isbn:9514258304.

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Abstract Prostate cancer is the most common solid tumor among men in Western industrialized countries. A major problem in prostate cancer treatment is the development of androgen-independence, as androgen-deprivation therapy is the basic therapy for the disease. Molecular mechanisms behind prostate cancer and androgen-independent growth development are poorly known. In this study, subtractive hybridization was used for the generation of a cDNA library specific for prostate cancer. Analysis of the cDNA library revealed over-expression of several ribosomal proteins namely L4, L5, L7a, L23
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Laniado, Marc. "Voltage activated Na+ and K+ channels in the LNCaP and PC-3 human prostate cancer cell lines and the association between Na+ channels and invasion in vitro." Thesis, Imperial College London, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.432044.

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Book chapters on the topic "LNCaP cell line"

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Harris, Stephen E., M. A. Harris, Z. Rong, et al. "Androgen Regulation of HBGF-I (aFGF) mRNA and Characferization of the Androgen-Receptor mRNA in the Human Prostate Carcinoma Cell Line-LNCaP/A-Dep." In Molecular and Cellular Biology of Prostate Cancer. Springer US, 1991. http://dx.doi.org/10.1007/978-1-4615-3704-5_35.

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Mohanty, Sanjib Kumar, and Yashaswi Nayak. "A REVIEW ON: ROLE OF GINGER (ZINGIBER OFFICINALE) TREATMENT AGAINST PROSTATE CANCER." In Futuristic Trends in Agriculture Engineering & Food Sciences Volume 3 Book 9. Iterative International Publishers, Selfypage Developers Pvt Ltd, 2024. http://dx.doi.org/10.58532/v3biag9p1ch4.

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The aim of the article is to describe the extraction process and how the bioactive compounds present inside the ginger reduces the effect of cancer and plays a role in anticancer activity. PC-3 and LNcAP cancer cells are taken for investigation. Both in vitro and in vivo experiments show the anticancer activity of the Zingiber officinale extracts. Numerous bioactive compounds were separated and noted by using different extraction procedures and their anticancer activities were tested later on PC-3 and LNcAP cancer cells by in silico analysis or by molecular docking of the plant contents agains
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Ayembilla, Jacob Apibilla, Phyllis Naa Yarley Otu, Eunice A. Dotse, et al. "Antioxidant and Anticancer Potential of Natural Cocoa Extract." In Technological Innovation Driving Sustainable Entrepreneurial Growth in Developing Nations. IGI Global, 2023. http://dx.doi.org/10.4018/978-1-6684-9843-9.ch007.

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The aim of this study was to investigate antioxidant and anticancer potentials of natural cocoa extracts. Antioxidant properties of the extracts were evaluated by DPPH assay, total phenolic content by Folin-Ciocalteau and reduced glutathione content by O-phthalaldehyde assays. Antiproliferative activity was also evaluated on leukaemia and prostate cancer cell lines using MTT assay. The hydroethanolic extracts of cocoa roots and beans and aqueous cocoa leaves showed high total antioxidant activities with the root extract having the strongest scavenging effect on DPPH and the highest total pheno
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Parra, Eduardo, Victor Rojas, and Jorge Ferreira. "Inhibition of Early Growth Response 1 by a Specific siRNA Modulates the Expression of p21Waf1/Cip1 and JNK-1 Proteins in Prostate PC-3 and LNCaP Carcinoma Cell Lines." In Advanced Research in Biological Science Vol. 4. B P International (a part of SCIENCEDOMAIN International), 2023. http://dx.doi.org/10.9734/bpi/arbs/v4/6238b.

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Conference papers on the topic "LNCaP cell line"

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Ottley, Edward, and Elspeth Gold. "Abstract 174: Identification of activin A mediated microRNAs in a human prostate cancer cell line (LNCaP)." In Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-174.

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Petri, A., M. Kyriazi, E. Alexandratou, M. Rallis, S. Gräfe, and D. Yova. "Evaluation of the PDT effect of Foscan and Fospeg in the LNCaP human prostate cancer cell line." In European Conferences on Biomedical Optics, edited by Ronald Sroka and Lothar D. Lilge. SPIE, 2009. http://dx.doi.org/10.1117/12.831881.

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Farooqi, Ammad A., and Shahzad Bhatti. "Abstract B63: Unraveling the paradoxes of ATM resensitized dynamics in LNCaP cell line via epigallocatechin-3-gallate (EGCG)." In Abstracts: AACR International Conference on the Science of Cancer Health Disparities‐‐ Sep 30-Oct 3, 2010; Miami, FL. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1055-9965.disp-10-b63.

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Petri, A., M. Kyriazi, E. Alexandratou, M. Rallis, S. Grafe, and D. Yova. "Evaluation of the PDT Effect of Foscan^® and Fospeg^® in the LNCaP Human Prostate Cancer Cell Line." In European Conference on Biomedical Optics. OSA, 2009. http://dx.doi.org/10.1364/ecbo.2009.7373_1i.

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Farooqi, A. A., Sadia Rashid, Taskeen M. Mashadi, Shahzad Bhatti, and M. Saleem. "Abstract A38: Therapeutic effect of epigallocatechin-3-gallate and silibinin on ATM dynamics in prostate cancer cell line LNCaP." In Abstracts: AACR International Conference on Translational Cancer Medicine-- Jul 11-14, 2010; San Francisco, CA. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1078-0432.tcmusa10-a38.

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Belic, Ale, Damjana Rozman, Manna Temesvari, et al. "Modelling of DHEA Effect on CYP1A2 Expression in LNCaP and MCF-7 Cell Lines." In 2013 8th EUROSIM Congress on Modelling and Simulation (EUROSIM). IEEE, 2013. http://dx.doi.org/10.1109/eurosim.2013.114.

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Galustian, Christine, Oliver Hickman, Richard A. G. Smith, et al. "Abstract 4233: The protein ps20 increases resistance to docetaxel in PC3 and LNCAP prostate cancer cell lines." In Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-4233.

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Benatar, Tania, Yutaka Amemiya, Christopher J. Wallis, et al. "Abstract 2522: MiRNA-652 induces neuroendocrine-like differentiation in LNCaP prostate cancer cells through decreased PP2A function." In Proceedings: AACR Annual Meeting 2017; April 1-5, 2017; Washington, DC. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.am2017-2522.

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Hussein, Ola, Feras Alali, Ala-Eddin Al Moustafa, and Ashraf Khalil. "Design, Synthesis and Biological Evaluation of Novel Chalcone Analogs as Potential Therapeutic Agents for Castration-Resistant Prostate Cancer." In Qatar University Annual Research Forum & Exhibition. Qatar University Press, 2020. http://dx.doi.org/10.29117/quarfe.2020.0179.

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Prostate cancer (PCa) is the second most frequently diagnosed malignancy, as well as a leading cause of cancer-related mortality in men globally. Despite the initial response to hormonal targeted therapy, the majority of patients ultimately progress to a lethal form of the disease, termed as castration-resistant prostate cancer (CRPC), which currently lacks curative therapeutic options and is associated with poor prognosis. Therefore, the development of novel treatment modalities for PCa is urgently needed. Chalcones, also known as 1,3-diphenyl-2-propen-1-ones, are among the highly attractive
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Harvey, T. J., C. Hughes, A. D. Ward, et al. "The Use of Raman Tweezers and Chemometric Analysis to Discriminate the Urological Cell Lines, PC-3, LNCaP, BPH and MGH-U1." In PERSPECTIVES IN VIBRATIONAL SPECTROSCOPY: Proceedings of the 2nd International Conference on Perspectives in Vibrational Spectroscopy (ICOPVS 2008). AIP, 2008. http://dx.doi.org/10.1063/1.3046192.

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