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Dissertations / Theses on the topic 'Lo'x'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Jimale, Badri. "E-Loox, a Hybrid Learning Management." University of Cincinnati / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1573574207633386.

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2

Loux, Jean C. [Verfasser]. "Beeinflussung des Verschlackungsverhaltens biomassegefeuerter Kraftwerke / Jean C Loux." Aachen : Shaker, 2009. http://d-nb.info/1159834547/34.

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3

Gaillard, Pierre. "Interfaces diffuses et flammes transcritiques LOX/H2." Thesis, Paris 6, 2015. http://www.theses.fr/2015PA066510/document.

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Dans les moteurs cryotechniques, les ergols sont refroidis pour être stockés sous forme liquide et limiter ainsi la taille des réservoirs. Ils sont ensuite mis sous pression, grâce à une turbopompe, avant d’être injectés dans la chambre de combustion. Pour augmenter les rendements des moteurs, la pression de chambre est augmentée et peut dépasser les pressions critiques des ergols. Le régime de combustion supercritique est alors appelé transcritique lorsque l’oxygène est injecté à une température inférieure à sa température critique avec une densité équivalente à celle d’un liquide. Ce régime

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4

Da, Costa Rocha Ines Isabel. "Effect of COX and LOX inhibitors on melanoma." Thesis, University College London (University of London), 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.550962.

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The incidence of malignant melanoma is increasing worldwide and becoming resistant to most chemotherapy and immunotherapy. The arachidonic acid pathway, through COX and LaX enzymes, lead to the formation of a variety of metabolically active products, the eicosanoids, with different roles in carcinogenesis beyond their primary homeostatic functions. Importantly, these enzymes were shown to be overexpressed in melanoma. Thus the aim of this PhD thesis was to determine the effect of COX and LOX inhibitors in melanoma survival and how they may influence melanoma development as well as to unveil ph

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5

Paul, Sunirmal. "Topological constraint of lox-cre site-specific recombination." Thesis, University of Cambridge, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.621634.

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6

Insley, John. "A lost Lancashire Place-Name: Lox(h)am." Deutsche Gesellschaft für Namenforschung, 2017. https://ul.qucosa.de/id/qucosa%3A31774.

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Der verschwundene Lancashire-Ort Lox(h)am lag vermutlich in der Gemeinde (parish) Penwortham. Der Ortsname Lox(h)am, der als Familienname überlebt hat, ist ein Kompositum, das aus einem Fluss- oder Bachnamen Lox < britisch *Losko- ‘der Verbogene’ und der Dativpluralform hūsum ‘bei den Häusern’, die formal sowohl altenglisch wie altskandinavisch sein kann, gebildet wird. Die Bedeutung wäre dann ‘bei den Häusern, die in Verbindung mit dem Flüsschen Lox stehen’. In diesem Beitrag wird vielmehr eine skandinavische Etymologie für hūsum bevorzugt. Die Anwesenheit von Skandinaviern in diesem Teil von

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7

Ellis, Tina Janelle. "LOX-1 genotype, dietary fat intake, and aerobic exercise training influence on endothelial function, oxidative stress, lipoprotein-lipids, and soluble LOX-1 /." College Park, Md. : University of Maryland, 2006. http://hdl.handle.net/1903/3813.

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Thesis (Ph. D.) -- University of Maryland, College Park, 2006.<br>Thesis research directed by: Kinesiology. Title from t.p. of PDF. Includes bibliographical references. Published by UMI Dissertation Services, Ann Arbor, Mich. Also available in paper.

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8

Morgan-Davies, Alwena H. "Generation and metabolism of 12/15-LOX esterified products." Thesis, Cardiff University, 2010. http://orca.cf.ac.uk/54395/.

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12/15-LOX is suspected to be involved in inflammatory disorders such as atherosclerosis but the exact mechanism of its action is unclear. Novel esterified products called 12- and 15- H(p)ETE-PEs were recently identified in murine macrophages and human monocytes respectively, which may at least partially account for the effects of 12/15-LOX (Maskrey et al, 2007). In this thesis the generation and metabolism of 12- and 15-H(p)ETE-PEs was characterised in murine macrophages and human monocytes. 12- and 15-H(p)ETE-PEs increased by 15 minutes following cell activation and were metabolised by three

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9

Lechner, Valentin. "Experimental study of LOX/CH4 flames in rocket engines." Electronic Thesis or Diss., université Paris-Saclay, 2024. http://www.theses.fr/2024UPAST040.

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Utiliser le méthane comme carburant dans les moteurs fusées présente beaucoup d'avantages mais la combustion avec de l'oxygène pur à haute pression reste mal comprise. D'un point de vue thermodynamique, le méthane et l'oxygène partagent des valeurs de point critique très similaires, ce qui rend difficile la prédiction du mélange des ergols, l'accrochage, la stabilité et la structure de la flamme. De plus, quand le méthane est injecté en excès, des aérosols peuvent être produits, pouvant obstruer les lignes, endommager la turbine et réduire le rendement.Une mise à jour approfondie des connaissa

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10

Sheren, Jamie Elizabeth. "Identifying functional lox sequences: A genomic search and randomized libraries." Connect to online resource, 2007. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3273689.

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11

Vohra, Ravinder Singh. "A cell biological analysis of the lox-1 scavenger receptor." Thesis, University of Leeds, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.503251.

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12

Lau, Chung-wing, and 劉仲永. "A study of emperor Yung-lo's decision to relocate China'scapital from Nanjing to Beijing." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1997. http://hub.hku.hk/bib/B31951405.

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13

Ivančić, Blaženko. "Untersuchungen zur Strömung und Verbrennung im Einspritzgebiet von LOX-H2-Raketenbrennkammern." [S.l. : s.n.], 2001. http://deposit.ddb.de/cgi-bin/dokserv?idn=962099880.

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14

Fong, Sheri Fumiko Tsuda. "The LOX and LOXL2 amine oxidases in colon and esophageal cancer." Thesis, University of Hawaii at Manoa, 2003. http://hdl.handle.net/10125/1258.

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Several members of the lysyl oxidase family of copper-dependent amine oxidases have been implicated in tumor development. The Iysyl oxidase (LOX) and LOX-like 2 (LOXL2) genes have been mapped to chromosomal regions affected by loss of heterozygosity (LOH) in several cancers, including those of the colon and esophagus. Indeed, there have been numerous reports of reduced LOX and a few reports of reduced LOXL2 expression in various cancers. Identification of microsatellite markers within the LOX locus and the LOXL2 gene allowed for evaluation ofthe status of these gene alleles in colon and esopha

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15

Murphy, Jane Elizabeth. "The human LOX-1 scavenger receptor : ligand binding, trafficking and processing." Thesis, University of Leeds, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.441231.

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16

Mägdefrau, Marion. "Ortsgerichtete Rekombination in Chlamydomonas reinhardtii am Beispiel des Cre/lox-Systems." kostenfrei, 2007. http://www.opus-bayern.de/uni-regensburg/volltexte/2008/880/.

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17

Lux, Johannes. "Flammenstabilisierung in einer Hochdruck-Raketenbrennkammer bei koaxialer Injektion von LOX, Methan /." Aachen : Shaker, 2008. http://d-nb.info/991819241/04.

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18

Mughal, Nadeem Akhter. "The LOX-1 scavenger receptor in atherosclerosis, angiogenesis and glucose metabolism." Thesis, University of Leeds, 2015. http://etheses.whiterose.ac.uk/11869/.

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The lectin-like oxidised low-density lipoprotein receptor-1 (LOX-1) is a class E scavenger receptor expressed on vascular cells including endothelium, smooth muscle and macrophages. LOX-1 binds to a variety of particles including oxidised low-density lipoprotein (OxLDL). At the cellular level, binding of LOX-1 to OxLDL appears to initiate endothelial dysfunction, apoptosis and foam cell formation, thereby linking the receptor to the pathogenesis of atherosclerosis. Experimental findings in pro-atherosclerotic LDLR-null mice reveal a significant reduction in plaque distribution with concomitant

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19

Chigusa, Yoshitsugu. "Reduced ABCA1 expression and low Nrf2 activation due to decreased lectin-like oxidized LDL receptor 1 (LOX-1)in the placenta are involved in preeclampsia." Kyoto University, 2014. http://hdl.handle.net/2433/188637.

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20

Grözinger, Anette. "Charakterisierung von Epidermis-Typ-Lipoxygenasen mit besonderer Berücksichtigung der e-LOX-3." [S.l.] : [s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=970076665.

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21

Lacey, Katie. "Regulation of ligand recognition and endocytosis by the LOX-1 scavenger receptor." Thesis, University of Leeds, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.589025.

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Lectin-like oxidised low-density lipoprotein receptor-1 (LOX-1) is a scavenger receptor that binds a wide range of ligands including oxidised low-density lipoprotein (OxLDL). LOX-1-mediated recognition of OxLDL can cause endothelial dysfunction and apoptosis. LOX-1 is implicated in foam cell formation and atherosclerotic plaque initiation and progression. The C-type lectin-like domain of LOX-1 binds OxLDL but the molecular basis for this recognition is unclear. Glycosidase or protease-mediated removal of exposed N-linked carbohydrates or protein epitopes on OxLDL led to the conclusion that LOX

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22

Petit, Xavier. "Etude de l'interaction cinétique chimique/turbulence dans une flamme cryotechnique LOx/CHA4." Phd thesis, INSA de Rouen, 2014. http://tel.archives-ouvertes.fr/tel-01020523.

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Le travail de cette thèse porte sur la modélisation de la combustion du méthane et de l'oxygène dans des conditions de pression et température typiques de celles rencontrées au sein des moteur-fusées. Pour cette application, des modèles de transports, de thermodynamiques et des équations d'état de type gaz réel ont été implémentés au sein du code de calcul compressible utilisé. Le formalisme des conditions aux limites a été étendu aux gaz réels. La validation de l'ensemble de cette modélisation a été effectuée. Pour la modélisation de la combustion, une méthode de chimie tabulée a été considér

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23

Ivančić, Blaženko. "Untersuchungen zur Strömung und Verbrennung im Einspritzgebiet von LOX-H 2 -Raketenbrennkammern." [S.l. : s.n.], 2001. http://www.bsz-bw.de/cgi-bin/xvms.cgi?SWB9360677.

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24

MATARAZZO, SARA. "Modulazione dell'attività del recettore LOX-1 attraverso farmaci che riducono il colesterolo." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2013. http://hdl.handle.net/2108/210567.

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Il recettore LOX-1 è maggiormente espresso in cellule endoteliali ed è il principale recettore delle lipoproteine ossidate a bassa densità (ox-LDL). LOX-1 viene iper-espresso in lesioni aterosclerotiche, ma è noto un suo coinvolgimento anche in patologie cardiovascolari, diabete e tumori. Le statine sono farmaci d’elezione per il trattamento di malattie cardiovascolari. Tuttavia, oltre ad un effetto ipocolesterolizzanti, esse sono in grado di inibire l’espressione del recettore LOX-1, mostrando un meccanismo d’azione indipendente da colesterolo, che però non è stato ancora del tutto cara

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25

Zasiura, Colette. "Characterisation and expression of pea lipoxygenase genes." Thesis, University of East Anglia, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.365059.

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26

Cimen, Ismail. "The Mechanism Of Anti Tumorigenic Effects Of 15-lox-1 In Colon Cancer." Phd thesis, METU, 2012. http://etd.lib.metu.edu.tr/upload/12615324/index.pdf.

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Colorectal cancer is the 4th most widespread cause of cancer mortality. One of the pathways that are involved in the development of colorectal cancer is the arachidonic acid metabolizing lipoxygenase (LOX) pathway. Inflammatory molecules formed from this pathway exert profound effects that may exacerbate the development and progression of colon and other cancers. 15 lipoxygenase-1 (15-LOX-1) is a member of LOX protein family that metabolizes primarily linoleic acid to 13-(S)-HODE. Several lines of evidence support an antiangiogenic role for 15-LOX-1, especially through 13-(S)-HODE. The express

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27

Lux, Johannes [Verfasser]. "Flammenstabilisierung in einer Hochdruck-Raketenbrennkammer bei koaxialer Injektion von LOX/Methan / Johannes Lux." Aachen : Shaker, 2008. http://d-nb.info/1161309497/34.

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28

Sakonsinsiri, Chadamas. "Carbohydrate-based inhibitors and multivalent probes for LOX-1 and DC-SIGN receptors." Thesis, University of Leeds, 2016. http://etheses.whiterose.ac.uk/14317/.

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29

Daou, Joe͏̈l. "Etude de la vaporisation-combustion des gouttes d'oxygène liquide (LOX) à haute pression." Aix-Marseille 1, 1994. http://www.theses.fr/1994AIX11026.

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Nous etudions la vaporisation-combustion des gouttes d'oxygene liquide (lox) en regime transcritique et supercritique, dans des conditions thermodynamiques typiques des moteurs-fusees. Apres une breve synthese de resultats theoriques importants (chapitre i), nous presentons au chapitre ii le cas de la combustion supercritique d'une goutte lox avec un schema reactionnel detaille. La flamme de diffusion obtenue est tres epaisse, essentiellement a cause de la reversibilite des reactions, et le taux maximal de degagement de chaleur se produit dans la proximite de l'interface. Le probleme de l'allu

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30

Almeida, Roberto Barbosa de. "Purification and characterization of LOX isoenzymes from germinating barley : biotransformation of complex lipids /." [S.l. : s.n.], 2005. http://www.gbv.de/dms/bs/toc/506584569.pdf.

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31

Sokola, Brent S. "DUAL LOX/COX INHIBITION: A NOVEL STRATEGY TO PREVENT NEUROVASCULAR LEAKAGE IN EPILEPSY." UKnowledge, 2018. https://uknowledge.uky.edu/pharmacy_etds/83.

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Epilepsy affects 3.4 million patients in the USA and is characterized by recurring seizures. The blood-brain barrier is leaky in epilepsy and may contribute to seizure progression but the mechanisms which cause this leakage are not fully understood. We hypothesized that seizures trigger LOX- and COX-mediated blood-brain barrier leakage and that dual LOX/COX inhibition prevents barrier leakage in vivo. To test this hypothesis, we administered either the dual LOX/COX inhibitor licofelone or a combination of the 5-LOX inhibitor zileuton and the COX-2 inhibitor celecoxib to rats that experienced s

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32

Shaw, Daniel 1993. "Streamlining minimal bacterial genomes : Analysis of the pan bacterial essential genome, and a novel strategy for random genome deletions in Mycoplasma pneumoniae." Doctoral thesis, Universitat Pompeu Fabra, 2019. http://hdl.handle.net/10803/668244.

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Understanding what constitutes a true Minimal Cell is a key challenge in synthetic biology. In this work, we present two new tools to aid in this endeavour. i) A novel methodology for minimising the Mycoplasma pneumoniae genome via random deletions of genetic material. This protocol utilises the Cre Lox system coupled with random transposon mutagenesis to create a population with random lox sites dispersed around the genome. This allows for a population of cells containing a high variability of large and small-scale deletions ranging from 50bp to 25Kb within M. pneumoniae. ii) The first large

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33

Kumari, Shalini [Verfasser]. "Sulfated Multivalent Polymers for inhibition of L-selectin and LOX-1 Receptors / Shalini Kumari." Berlin : Freie Universität Berlin, 2019. http://d-nb.info/1178424499/34.

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34

Ackermann, Jens [Verfasser]. "Expression von LOX-1 in Atherektomie-Proben bei Patienten mit Akutem Koronarsyndrom / Jens Ackermann." Greifswald : Universitätsbibliothek Greifswald, 2014. http://d-nb.info/1050619501/34.

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35

Silva, Roseli da. "Expressão gênica da família das lisil oxidases e papel funcional de LOX em astrocitomas." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/5/5138/tde-12012015-091413/.

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O desenvolvimento e invasão de tumores cerebrais primários são diretamente influenciados pela matriz extracelular. Considerando que lisil oxidase (LOX) e os demais membros da família das lisil oxidases (LOXL1, LOXL2, LOXL3 e LOXL4) apresentam complexidade tanto estrutural quanto funcional e estão envolvidos em processos biológicos vitais, como motilidade celular, sinalização celular e regulação gênica, a desregulação da expressão destas proteínas pode levar à gênese e progressão tumoral. O presente trabalho teve como objetivos avaliar os níveis de expressão dos genes que codificam todos os mem

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36

Moriwaki, Hideaki. "Ligand spectificity of LOX-1, a novel endothelial receptor for oxidized low density lipoprotein." Kyoto University, 1998. http://hdl.handle.net/2433/182251.

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37

Shiu, Wing-ming Sammy, and 邵永明. "Role of lectin-like oxidized low density lipoprotein receptor-1 (LOX-1) in diabetes mellitus." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hub.hku.hk/bib/B50534075.

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Lectin-like oxidized low density lipoprotein receptor-1 (LOX-1) is a recently identified scavenger receptor expressed in endothelial cells and mediates the uptake of oxidized LDL (oxLDL). LOX-1 expression is increased in atherosclerotic lesions in animals and humans. Recent evidence has suggested that LOX-1 is involved in the development and progression of atherosclerosis. In addition to endothelial cells, it has also been reported that LOX-1 is also expressed by other cell types like macrophages. It is a multi-ligand class E scavenger receptor and cellular expression of LOX-1 can be induced

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38

Taveira-Marques, R. "Fate-mapping neural stem cells in the mouse ventral neural tube by Cre-lox transgenesis." Thesis, University College London (University of London), 2011. http://discovery.ucl.ac.uk/1333991/.

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Neurons and glia (astrocytes and oligodendrocytes) are the two major cell types that make up the central nervous system (CNS). They are generated from precursor domains within the neuroepithelial germinal zone (ventricular zone, VZ) that surrounds the ventricles of the brain and the central canal of the spinal cord (the embryonic neural tube). In general, neurons are generated before glia. The intra-spinal circuits that control movement and locomotion are made up of different neuronal and glial elements that develop separately but come together to form interconnected functional units. To under

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39

Nieuwoudt, Melanie. "LTP1 and LOX-1 in barley malt and their role in beer production and quality." Thesis, Stellenbosch : Stellenbosch University, 2014. http://hdl.handle.net/10019.1/86558.

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Thesis (PhD)--Stellenbosch University, 2014.<br>ENGLISH ABSTRACT: Selection of raw materials for a consistent and high quality end product has been a challenge for brewers globally. Various different factors may influence quality and although a great number of methods for malt analysis exist today for the prediction of end product quality, some still do not accurately represent malt performance in beer. This research focussed on determining parameters in malts to predict two of the major beer quality determining factors namely, foam- and flavour stability. Specific biochemical markers in

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40

Godinho, Camila Capel. "Análise metabolômica da bioatividade em vias COX e LOX-dependentes de plantas da subtribo Lychnophorinae." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/60/60138/tde-03102016-143050/.

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Muitas substâncias das espécies de Lychnophorinae (Asteraceae) são relatadas como inibidoras da síntese de mediadores da cascata do processo inflamatório. Nesse processo, duas enzimas são essenciais e atuam no metabolismo do ácido araquidônico, formado em processos inflamatórios: ciclooxigenase (COX) e lipoxigenase (LOX). A análise de impressões digitais metabólicas é um método capaz de fornecer informações sobre o objeto de estudo através da utilização de ferramentas estatísticas, além de possibilitar a correlação desses dados com outros utilizando métodos in silico. O objetivo deste estudo f

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41

Han, Yafei. "Effect of fruit types and temperature on formation of volatiles in the lipoxygenase (LOX) pathway." The Ohio State University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=osu1430955718.

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42

Hoshikawa, Hajime. "High affinity binding of oxidized LDL to mouse lectin-like oxidized LDL receptor (LOX-1)." Kyoto University, 1999. http://hdl.handle.net/2433/182282.

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43

Kvist, A. P. (Ari-Pekka). "Type XIII collagen:organization and chromosomal localization of the mouse gene, distance between human COL13A1 and prolyl 4-hydroxylase α-subunit genes, and generation of mice expressing an N-terminally altered type XIII collagen". Doctoral thesis, Oulun yliopisto, 1999. http://urn.fi/urn:isbn:9514253949.

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Abstract The complete exon-intron organization of the gene coding for the mouse α1(XIII) collagen chain, Col13a1, was characterized from genomic clones and multiple transcription initiation points were determined. Detailed comparison of the human and mouse genes showed that the exon-intron structures are completely conserved between the species, and both genes have their 5' untranslated region preceded by a highly conserved putative promoter region. The chromosomal location of the mouse gene was determined to be at chromosome 10, band B4, between markers D10Mit5 – (2.3 ± 1.6 cM) – Col13a1 – (3

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44

Andersson, Nina. "Förslag till optimering av bladtillverkning i syfte att sänka tillverkningskostnaderna för VINCI LOX och LH2 turbinerna." Thesis, University West, Department of Technology, Mathematics and Computer Science, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:hv:diva-725.

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45

Huggins, Iain D. "The involvement of P2X7R signalling in LOX mediated formation of a pre-metastatic niche in bone." Thesis, University of Sheffield, 2016. http://etheses.whiterose.ac.uk/12272/.

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Metastasis to bone seriously complicates treatment of cancer, resulting in an incurable and debilitating condition which can greatly decrease quality of life as a result of excessive bone destruction. Recent research has identified tumour secreted LOX as a contributor to cancer induced bone loss, by generating osteolytic lesions prior to cancer cell arrival, thus contributing to pre-metastatic niche formation, and enhancing metastatic cell recruitment and survival in bone. Previous research has also observed that LOX accumulates at areas of pressure, and is hypoxically regulated, highlighting

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46

Borel, Agnès. "Les lysyl oxydases LOX, LOXL et LOXL2 : caractérisation et rôle dans la réticulation des protéines matricielles." Lyon 1, 2003. http://www.theses.fr/2003LYO10020.

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La LOX est un enzyme extracellulaire responsable de la réticulation des fibres de collagène et d'élastine conférant aux tissus conjonctifs leurs propriétés de résistance mécanique et élastique. Cette protéine a également été impliquée dans des processus de chimiotactisme, de régulation du cycle cellulaire et a été identifiée comme suppresseur de l'oncogène ras (rrg). Récemment quatre gènes codant des protéines très similaires à la LOX ont été identifiés et leur existence remet en cause l'hypothèse d'un rôle unique des la LOX sur toutes ces activités. Nous nous sommes attachés à l'étude des pro

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47

Ducrocq, Aurélie. "Conception, synthèse et évaluation pharmacologique de composés diaryles originaux, potentiellement inhibiteurs mixtes COX -2/5-LOX." Lille 1, 2004. https://pepite-depot.univ-lille.fr/RESTREINT/Th_Num/2004/50376-2004-141.pdf.

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Le cancer étant la deuxième cause de mortalité dans les pays industrialisés après les maladies cardiovasculaires, de nombreuses stratégies thérapeutiques sont élaborées pour le combattre. Actuellement, un nouvel axe de recherche prometteur se développe autour des deux principales enzymes de métabolisation de l'acide arachidonique : la cyclooxygénase-2 (COX-2) et la 5-lipoxygénase (5-LOX). En effet, celles-ci sont surexprimées dans de nombreuses tumeurs et certains de leurs inhibiteurs présentent des activités proapoptotique et/ou antiangiogénique marquées. À partir des structures du Celecoxib,

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Stecher, Stephanie-Susanne [Verfasser]. "Wirkung von Mediatoren auf die LOX-1- und eNOS-Expression beim akuten Koronarsyndrom / Stephanie-Susanne Stecher." Greifswald : Universitätsbibliothek Greifswald, 2011. http://d-nb.info/1018191399/34.

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Shipley, Lindsey C. BS, Harika MD Balagoni, Janet Lightner, Victoria PhD Palau та Koyamangalath MD Krishnan. "15 Lox 1 Up-regulation and Cytotoxicity with γ-tocotrienol in HCT-116 Colon Cancer Cells". Digital Commons @ East Tennessee State University, 2018. https://dc.etsu.edu/asrf/2018/schedule/154.

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Abstract:

Colorectal cancer is the second leading cause of cancer-related deaths in the United States and the third most common cancer in men and women. Vitamin E is a lipid soluble antioxidant that exists as eight structurally different isoforms of tocopherols and tocotrienols. Recent experimental, and molecular studies suggest that γ-tocotrienol (GT3) may be a more potent cancer-preventive form of vitamin E. 15-lipoxygenase-1 (15-LOX-1) and its product 13-S-hydroxyoctadecadienoic acid (13-S-HODE) are decreased in colon cancer cells. 15 LOX-1 is considered a tumor suppressor gene in colon carcinogene

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Machado, Caroline. "STUDIES OF ERGOT ALKALOID BIOSYNTHESIS GENES IN CLAVICIPITACEOUS FUNGI." UKnowledge, 2004. http://uknowledge.uky.edu/gradschool_diss/433.

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Abstract:

Neotyphodium species, endophytic fungi associated with cool-season grasses, enhance host fitness and stress tolerance, but also produce biologically active alkaloids including ergot alkaloids associated with fescue toxicosis in grazing animals. One approach to reduce fescue toxicosis is to manipulate genes in the ergot alkaloid pathway. The gene, dmaW, encoding the first pathway-specific step in ergot alkaloid biosynthesis, was cloned previously from Claviceps spp. and its function was demonstrated by expression in yeast. Putative homologs have been cloned from Neotyphodium coenophialum (from

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