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Journal articles on the topic 'Lo'x'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

K.R, .Yo'ldashev, Sh.O.Odamboyeva, and X.D.Shavkatova. "Tabiiy holda uchraydigan suv o`simliklarning xilma-xilligi va ularning chorvachilikdagi ahamiyati (Xorazm viloyati sharoitida)." Multidisciplinary Journal of Science and Technology 5, no. 5 (2025): 694–97. https://doi.org/10.5281/zenodo.15442639.

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Ushbu maqolada Xorazm viloyati sharoitidagi suv havzalarida tabiiy holda uchraydigan qamish  va qo`ga turkumi o`simliklarining  tur tarkibi va bioekologik xususiyatlari haqida malumotlar berilgan.  Qamish turkumiga kiruvchi  oddiy qamish (Phragmites communis),ko’l qamishi (Scirpus lacustris), tugunakli qamish (Bolboschoenus maritimus)hamda qo`g`a turkumining Kengbarg qo’g’a- T.latifolia L, Laksman qo’g’asi – T.laxmannii Lepech, , T.minima Funk, Nozik qo’g’a-T.angustata Bory et Chaub turlarining geografik tarqalishi,bioekologik

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2

Capozzi, Rocco, Pia Pera, and Ann Goldstein. "Lo's Diary." World Literature Today 74, no. 2 (2000): 429. http://dx.doi.org/10.2307/40155753.

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3

Inge Carpenter, Lindsay. "LOEX 2018." Journal of Information Literacy 12, no. 1 (2018): 147. http://dx.doi.org/10.11645/12.1.2480.

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4

Inge Carpenter, Lindsay. "LOEX 2018." Journal of Information Literacy 12, no. 1 (2018): 147. http://dx.doi.org/10.11645/jil.v12i1.2480.

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5

Milana, Joseph. "Factorization at lowx." Physical Review D 34, no. 3 (1986): 761–70. http://dx.doi.org/10.1103/physrevd.34.761.

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6

Rabb, Margo. "Lox." Chicago Review 43, no. 3 (1997): 83. http://dx.doi.org/10.2307/25304192.

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7

Shirato, Linda. "LOEX and library instruction." Reference Services Review 27, no. 3 (1999): 214–19. http://dx.doi.org/10.1108/00907329910283124.

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8

Lo, S. "Availability of Lo's mycoplasma." Science 249, no. 4965 (1990): 111. http://dx.doi.org/10.1126/science.2371557.

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9

Lo, S. C. "Availability of Lo's Mycoplasma." Science 249, no. 4965 (1990): 111. http://dx.doi.org/10.1126/science.249.4965.111-a.

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10

Kamagi, Tri Wahyudi N., and Devi Tanggasari. "Karakteristik Mutu Kimia Masker Wajah Beras Putih (Oryza sativa)-Lo’i Monca Tradisional Dompu." Biocity Journal of Pharmacy Bioscience and Clinical Community 1, no. 1 (2022): 1–9. http://dx.doi.org/10.30812/biocity.v1i1.2458.

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People in Dompu Regency West Nusa Tenggara have always used traditional face mask products, namely masks lo'i monca which protect facial skin from the sun when they are active all day outdoors. Dompu traditional masks (lo'i monca) are made from rice, tamarind shoots, bangle, curcuma, temugiring, and galangal. This study aims to determine the chemical quality offacial masks in lo'i monca terms of pH, water content and antioxidants. This type of research is a type of laboratory experimental research. Based on the results of laboratory tests, the average pH value obtained by the face mask powder

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11

Ogura, Sayoko, Akemi Kakino, Yuko Sato, et al. "LOX-1." Circulation Journal 73, no. 11 (2009): 1993–99. http://dx.doi.org/10.1253/circj.cj-09-0587.

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12

Sawamura, Tatsuya, Akemi Kakino, and Yoshiko Fujita. "LOX-1." Current Opinion in Lipidology 23, no. 5 (2012): 439–45. http://dx.doi.org/10.1097/mol.0b013e32835688e4.

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13

Vincent, Christelle, Rémi Fiancette, Magali Donnard, et al. "5-LOX, 12-LOX and 15-LOX in immature forms of human leukemic blasts." Leukemia Research 32, no. 11 (2008): 1756–62. http://dx.doi.org/10.1016/j.leukres.2008.05.005.

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14

Barros, Josie Gomes de Almeida, Rita Maria Alves de Moraes, Newton Deniz Piovesan, Everaldo Gonçalves de Barros, and Maurilio Alves Moreira. "Efeito do inibidor de protease Kunitz sobre níveis de lipoxigenases em sementes de soja." Ciência e Agrotecnologia 32, no. 4 (2008): 1126–32. http://dx.doi.org/10.1590/s1413-70542008000400014.

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As lipoxigenases (LOX) são responsáveis pelo "beany flavor", sabor característico da soja [Glycine max. (L.) Merrill], que é o maior obstáculo ao consumo da soja nos países ocidentais. O inibidor de tripsina Kunitz (KTI) é responsável por 80% da inibição da atividade tríptica, além de provocar hiperplasia pancreática em animais monogástricos. Essas duas características são muito importantes em programas de melhoramento que visam à melhoria da qualidade da soja. Objetivou-se, neste trabalho verificar o efeito do inibidor de protease (KTI), sobre níveis de LOX em sementes de soja, nos seguintes

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15

Gonen, Bilal, and Badri Jimale. "E-Loox, A Hybrid Learning Management System." International Journal of Software Engineering & Applications 12, no. 1 (2021): 11–23. http://dx.doi.org/10.5121/ijsea.2021.12102.

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E-loox is an educational software application that has been designed specifically for students located in areas with limited Internet access. Unlike the majority of existing educational applications, E-loox is a “hybrid app”– meaning it can function both on and offline. As a hybrid app, E-loox allows students to complete assignments, access course materials, and conduct research in places where there is no Internet access. While global Internet access has expanded rapidly in the last decade, there are still more than 3.5 billion people who lack access, including approximately 60 million people

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16

SIEBERT, Malte, Peter KRIEG, Wolf D. LEHMANN, Friedrich MARKS, and Gerhard FÜRSTENBERGER. "Enzymic characterization of epidermis-derived 12-lipoxygenase isoenzymes." Biochemical Journal 355, no. 1 (2001): 97–104. http://dx.doi.org/10.1042/bj3550097.

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Substrate selectivity and other enzymic characteristics of two epidermis-derived lipoxygenases (LOXs), the epidermis-type (e) (12S)-LOX and (12R)-LOX, were compared with those of the platelet-type (p) (12S)-LOX. In contrast with p(12S)-LOX, e(12S)-LOX and (12R)-LOX exhibited no or very low reactivity towards the customary substrates linoleic acid and arachidonic acid but metabolized the corresponding fatty acid methyl esters, which, in contrast, were not accepted as substrates by p(12S)-LOX. Other esters of arachidonic acid and linoleic acid, including propan-2-yl and cholesterol esters, 1-pal

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17

Horie, Jun, Koichiro Takahashi, Shuuichi Shiranita, Kunihiko Anami, and Shinichiro Hayashi. "Validation of Clinical Characteristics and Effectiveness of Pulmonary Rehabilitation in a COPD Population with Discrepancy between Exercise Tolerance and FEV1." Healthcare 9, no. 1 (2021): 53. http://dx.doi.org/10.3390/healthcare9010053.

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This study’s objective was to examine the characteristics of patients with chronic obstructive pulmonary disease (COPD) presenting with various exercise tolerance levels. A total of 235 patients with stable COPD were classified into 4 groups: (1) LoFlo + HiEx—patients with a six-minute walking distance (6MWD) ≥350 m and percentage of predicted forced expiratory volume in 1 s (%FEV1.0) <50%; (2) HiFlo + HiEx—patients with a 6MWD ≥350 m and a %FEV1.0 ≥50%; (3) LoFlo + LoEx—patients with a 6MWD < 350 m and %FEV1.0 < 50%; and (4) HiFlo + LoEx—patients with a 6MWD <350 m and %FEV1.0 ≥ 5

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18

Schoenman, Leonard. "LOX/propane and LOX/ethanol combustion chamber heat transfer." Journal of Propulsion and Power 7, no. 4 (1991): 538–48. http://dx.doi.org/10.2514/3.23360.

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19

Piette, Mary I., and Deleyne Wentz. "Conference Circuit: "LOEX" goes west!" College & Research Libraries News 55, no. 10 (1994): 639–40. http://dx.doi.org/10.5860/crln.55.10.639.

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20

Taylor, Terry. "LOEX of the West 2000." Research Strategies 17, no. 4 (2000): 359–61. http://dx.doi.org/10.1016/s0734-3310(01)00059-3.

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21

Basu, Rahul. "Lowx physics and structure functions." Pramana 51, no. 1-2 (1998): 205–16. http://dx.doi.org/10.1007/bf02827492.

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22

Tran, Allison, Tom Babayan, Chris Christion, and Cathy Palmer. "LOEX‐of‐the‐West Conference." Library Hi Tech News 23, no. 7 (2006): 16–17. http://dx.doi.org/10.1108/07419050610704312.

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23

Tran, Michelle, Kevin Yang, Alisa Glukhova, Michael Holinstat, and Theodore Holman. "Inhibitory Investigations of Acyl-CoA Derivatives against Human Lipoxygenase Isozymes." International Journal of Molecular Sciences 24, no. 13 (2023): 10941. http://dx.doi.org/10.3390/ijms241310941.

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Lipid metabolism is a complex process crucial for energy production resulting in high levels of acyl-coenzyme A (acyl-CoA) molecules in the cell. Acyl-CoAs have also been implicated in inflammation, which could be possibly linked to lipoxygenase (LOX) biochemistry by the observation that an acyl-CoA was bound to human platelet 12-lipoxygenase via cryo-EM. Given that LOX isozymes play a pivotal role in inflammation, a more thorough investigation of the inhibitory effects of acyl-CoAs on lipoxygenase isozymes was judged to be warranted. Subsequently, it was determined that C18 acyl-CoA derivativ

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24

Paudel, Shrestha, Cho, et al. "Assessing Drug Interaction and Pharmacokinetics of Loxoprofen in Mice Treated with CYP3A Modulators." Pharmaceutics 11, no. 9 (2019): 479. http://dx.doi.org/10.3390/pharmaceutics11090479.

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Loxoprofen (LOX) is a non-selective cyclooxygenase inhibitor that is widely used for the treatment of pain and inflammation caused by chronic and transitory conditions. Its alcoholic metabolites are formed by carbonyl reductase (CR) and they consist of trans-LOX, which is active, and cis-LOX, which is inactive. In addition, LOX can also be converted into an inactive hydroxylated metabolite (OH-LOXs) by cytochrome P450 (CYP). In a previous study, we reported that CYP3A4 is primarily responsible for the formation of OH-LOX in human liver microsomes. Although metabolism by CYP3A4 does not produce

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25

Müller, V., M. V. Amé, V. Carrari, J. Gieco, and R. Asis. "Lipoxygenase Activation in Peanut Seed Cultivars Resistant and Susceptible to Aspergillus parasiticus Colonization." Phytopathology® 104, no. 12 (2014): 1340–48. http://dx.doi.org/10.1094/phyto-12-13-0338-r.

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Accumulative evidence indicates that the lipoxygenase (LOX) pathway plays a significant role in the Aspergillus–seed interaction, such as interfering with activities of endogenous fungal oxylipins or producing antimicrobial compounds and signaling molecules. In this study, we characterized the LOX pathway in peanut seed during Aspergillus parasiticus colonization in a model of two cultivars distinguished as resistant (‘PI337394’) and susceptible (‘Florman INTA’) to Aspergillus spp. infection and aflatoxin contamination. The LOX activity together with the content of LOX substrate and LOX produc

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26

Nguyen, Xinh-Xinh, Tetsuya Nishimoto, Takahisa Takihara, Logan Mlakar, Amy D. Bradshaw, and Carol Feghali-Bostwick. "Lysyl oxidase directly contributes to extracellular matrix production and fibrosis in systemic sclerosis." American Journal of Physiology-Lung Cellular and Molecular Physiology 320, no. 1 (2021): L29—L40. http://dx.doi.org/10.1152/ajplung.00173.2020.

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Pulmonary fibrosis is one of the important causes of morbidity and mortality in fibroproliferative disorders such as systemic sclerosis (SSc) and idiopathic pulmonary fibrosis (IPF). Lysyl oxidase (LOX) is a copper-dependent amine oxidase whose primary function is the covalent crosslinking of collagens in the extracellular matrix (ECM). We investigated the role of LOX in the pathophysiology of SSc. LOX mRNA and protein levels were increased in lung fibroblasts of SSc patients compared with healthy controls and IPF patients. In vivo, bleomycin induced LOX mRNA expression in lung tissues, and LO

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27

Misaka, Tomofumi, Satoshi Suzuki, Nobuo Sakamoto, et al. "Significance of Soluble Lectin-Like Oxidized LDL Receptor-1 Levels in Systemic and Coronary Circulation in Acute Coronary Syndrome." BioMed Research International 2014 (2014): 1–7. http://dx.doi.org/10.1155/2014/649185.

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Background.Soluble lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) level is a novel biomarker for diagnosis of acute coronary syndrome (ACS); however, this level in the coronary circulation has yet to be examined.Methods.Twenty-seven consecutive patients with ACS and 40 patients with effort angina pectoris (EAP) undergoing percutaneous coronary intervention (PCI) had levels of soluble LOX-1 and LOX-1 index measured in paired blood samples from aorta (Ao) and coronary sinus (CS) just prior to the PCI.Results.We found positive correlations between soluble LOX-1 levels in the Ao a

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28

Ballester-Servera, Carme, Judith Alonso, Laia Cañes, et al. "Lysyl Oxidase in Ectopic Cardiovascular Calcification: Role of Oxidative Stress." Antioxidants 13, no. 5 (2024): 523. http://dx.doi.org/10.3390/antiox13050523.

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Lysyl oxidase (LOX)-mediated extracellular matrix crosslinking modulates calcification in atherosclerosis and aortic valve disease; however, this enzyme also induces oxidative stress. We addressed the contribution of LOX-dependent oxidative stress to cardiovascular calcification. LOX is upregulated in human-calcified atherosclerotic lesions and atheromas from atherosclerosis-challenged LOX transgenic mice (TgLOXVSMC) and colocalized with a marker of oxidative stress (8-oxo-deoxyguanosine) in vascular smooth muscle cells (VSMCs). Similarly, in calcific aortic valves, high LOX expression was det

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29

Staiculescu, Marius Catalin, Jungsil Kim, Robert P. Mecham, and Jessica E. Wagenseil. "Mechanical behavior and matrisome gene expression in the aneurysm-prone thoracic aorta of newborn lysyl oxidase knockout mice." American Journal of Physiology-Heart and Circulatory Physiology 313, no. 2 (2017): H446—H456. http://dx.doi.org/10.1152/ajpheart.00712.2016.

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Mutations in lysyl oxidase (LOX) are associated with thoracic aortic aneurysm and dissection (TAAD). Mice that do not express Lox ( Lox−/−) die soon after birth and have 60% and 40% reductions in elastin- and collagen-specific cross-links, respectively. LOX inactivation could also change the expression of secreted factors, the structural matrix, and matrix-associated proteins that constitute the aortic matrisome. We hypothesized that absence of Lox will change the mechanical behavior of the aortic wall because of reduced elastin and collagen cross-linking and alter the expression levels of mat

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30

Wang, Jian Hui, Dong Min Liu, An Ni Zheng, et al. "Preliminary Purification and Distribution of Lipoxygenase in Grass Carp." Advanced Materials Research 550-553 (July 2012): 1468–72. http://dx.doi.org/10.4028/www.scientific.net/amr.550-553.1468.

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The lipoxygenase (LOX) in grass carp can catalyze the oxidation of polyunsaturated fatty acids even their esters, resulting in rancidity deterioration of grass carp and its products during the process and storage. Preliminary purification, quantitative determination and distribution of grass carp muscular LOX were investigated in the present study. LOX activity of the grass carp muscle was measured to be 35.17 KU/g and its molecular weight was 95.71 kDa identified by SDS-PAGE. Using previously reported extraction methods such as twice salting-out and once dialysis, the LOX protein content in t

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31

Lee, Yoon Se, Yangsoon Park, Minsu Kwon, et al. "Expression of Lysyl Oxidase Predictive of Distant Metastasis of Laryngeal Cancer." Otolaryngology–Head and Neck Surgery 156, no. 3 (2017): 489–97. http://dx.doi.org/10.1177/0194599816685698.

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Objective To investigate the prognostic significance of lysyl oxidase (LOX) expression in laryngeal cancer. Study Design Retrospective chart review and histologic analysis. Setting Tertiary referral academic center. Subjects and Methods Patients (N = 100) underwent surgical treatment for laryngeal cancer and had tissue specimens available. Immunohistochemical staining for LOX was performed on laryngeal cancer tissue microarrays, and the proportion and intensity of staining were evaluated. Patients with LOX scores ≤6 were classified into the low LOX group, while those with scores >6 were cla

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32

Wang, W., P. H. A. J. M. van Gelder, J. K. Vrijling, and X. Chen. "Detecting long-memory: Monte Carlo simulations and application to daily streamflow processes." Hydrology and Earth System Sciences Discussions 3, no. 4 (2006): 1603–27. http://dx.doi.org/10.5194/hessd-3-1603-2006.

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Abstract. The Lo's R/S tests (Lo, 1991), GPH test (Geweke and Porter-Hudak, 1983) and the maximum likelihood estimation method implemented in S-Plus (S-MLE) are evaluated through intensive Mote Carlo simulations for detecting the existence of long-memory. It is shown that, it is difficult to find an appropriate lag q for Lo's test for different AR and ARFIMA processes, which makes the use of Lo's test very tricky. In general, the GPH test outperforms the Lo's test, but for cases where there is strong autocorrelations (e.g., AR(1) processes with φ=0.97 or even 0.99), the GPH test is totally use

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33

Akhmedov, Alexander, Nicole R. Bonetti, Martin F. Reiner, et al. "Deleterious role of endothelial lectin-like oxidized low-density lipoprotein receptor-1 in ischaemia/reperfusion cerebral injury." Journal of Cerebral Blood Flow & Metabolism 39, no. 11 (2018): 2233–45. http://dx.doi.org/10.1177/0271678x18793266.

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Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is implicated in cardiovascular disease by modulating apoptosis and oxidative stress. We hypothesized that LOX-1 may be involved in pathophysiology of stroke by mediating ischaemia/reperfusion (I/R)-dependent cell death. Transient middle cerebral artery occlusion (tMCAO) was performed in wild-type (WT) mice, endothelial-specific LOX-1 transgenic mice (eLOX-1TG) and WT animals treated with LOX-1 silencing RNA (siRNA). In WT mice exposed to tMCAO, LOX-1 expression and function were increased in the MCA. Compared to WT animals, eLOX-

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34

Upadhyay, Rakesh K., Marvin Edelman, and Autar K. Mattoo. "Identification, Phylogeny, and Comparative Expression of the Lipoxygenase Gene Family of the Aquatic Duckweed, Spirodela polyrhiza, during Growth and in Response to Methyl Jasmonate and Salt." International Journal of Molecular Sciences 21, no. 24 (2020): 9527. http://dx.doi.org/10.3390/ijms21249527.

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Lipoxygenases (LOXs) (EC 1.13.11.12) catalyze the oxygenation of fatty acids and produce oxylipins, including the plant hormone jasmonic acid (JA) and its methyl ester, methyl jasmonate (MeJA). Little information is available about the LOX gene family in aquatic plants. We identified a novel LOX gene family comprising nine LOX genes in the aquatic plant Spirodela polyrhiza (greater duckweed). The reduced anatomy of S. polyrhiza did not lead to a reduction in LOX family genes. The 13-LOX subfamily, with seven genes, predominates, while the 9-LOX subfamily is reduced to two genes, an opposite tr

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35

Kumari, Suchitra, A. Raj Kumar Patro, Baijayantimala Mishra, Saubhagya Kumar Jena, and Sweta Singh. "Serum Lysyl Oxidase Levels and Lysyl Oxidase Gene Polymorphism in Ovarian Cancer Patients of Eastern Indian Population." Diagnostics 12, no. 1 (2021): 53. http://dx.doi.org/10.3390/diagnostics12010053.

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(1) Background: Lysyl oxidase (LOX) plays a dual role in carcinogenesis and studies show a higher risk of cancer in LOX G473A variants. The present study evaluated the pattern of LOX G473A polymorphism (rs1800449) and serum LOX levels in ovarian cancer patients. (2) Methods: Serum LOX levels were estimated by enzyme linked immunosorbent assay (ELISA). A polymorphism of rs1800449 of LOX gene was detected by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Selected samples were sequenced for external validation. (3) Results: A majority of study participan

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36

MELLON, J. E., and P. J. COTTY. "No Effect of Soybean Lipoxygenase on Aflatoxin Production in Aspergillus flavus–Inoculated Seeds." Journal of Food Protection 65, no. 12 (2002): 1984–87. http://dx.doi.org/10.4315/0362-028x-65.12.1984.

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Soybean lines lacking lipoxygenase (LOX) activity were compared with soybean lines having LOX activity for the ability to support growth and aflatoxin B1 production by the fungal seed pathogen Aspergillus flavus. Whole seeds, broken seeds, and heat-treated (autoclaved) whole seeds were compared. Broken seeds, irrespective of LOX presence, supported excellent fungal growth and the highest aflatoxin levels. Autoclaved whole seeds, with or without LOX, produced good fungal growth and aflatoxin levels approaching those of broken seeds. Whole soybean seeds supported sparse fungal growth and relativ

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Hu, Wei, Qiuhong Xie, and Hongyu Xiang. "Improved scFv Anti-LOX-1 Binding Activity by Fusion with LOX-1-Binding Peptides." BioMed Research International 2017 (2017): 1–9. http://dx.doi.org/10.1155/2017/8946935.

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The oxidized low-density lipoprotein receptor-1 (LOX-1) targeted single-chain variable fragment (scFvs) is a promising molecule for the targeted delivery of imaging and therapeutic molecules of atherosclerotic diseases; however, its applications are limited by the inherent low antigen affinity. In this study, the three-dimensional (3D) model of the anti-LOX-1 scFv was constructed and its docking with the LOX-1 protein was developed. To improve the LOX-1-binding activity, the anti-LOX-1 scFv was designed to fuse with one of three LOX-1-binding heptapeptides, LTPATAI, FQTPPQL, and LSIPPKA, at it

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38

Wu, Zhuang, Tatsuya Sawamura, Anna K. Kurdowska, Hong-Long Ji, Steven Idell, and Jian Fu. "LOX-1 Deletion Improves Neutrophil Responses, Enhances Bacterial Clearance, and Reduces Lung Injury in a Murine Polymicrobial Sepsis Model." Infection and Immunity 79, no. 7 (2011): 2865–70. http://dx.doi.org/10.1128/iai.01317-10.

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ABSTRACTInflammatory tissue injury and immunosuppression are the major causes of death in sepsis. Novel therapeutic targets that can prevent excessive inflammation and improve immune responses during sepsis could be critical for treatment of this devastating disease. LOX-1 (lectin-like oxidized low-density lipoprotein receptor-1), a membrane protein expressed in endothelial cells, has been known to mediate vascular inflammation. In the present study, we demonstrated that LOX-1 deletion markedly improved the survival rate in a murine model of polymicrobial sepsis. Wild-type (LOX-1+/+) and LOX-1

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39

Yeung, Jennifer, Patrick L. Apopa, Joanne Vesci, et al. "12-lipoxygenase activity plays an important role in PAR4 and GPVI-mediated platelet reactivity." Thrombosis and Haemostasis 110, no. 09 (2013): 569–81. http://dx.doi.org/10.1160/th13-01-0014.

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SummaryFollowing initial platelet activation, arachidonic acid is metabolised by cyclooxygenase-1 and 12-lipoxygenase (12-LOX). While the role of 12-LOX in the platelet is not well defined, recent evidence suggests that it may be important for regulation of platelet activity and is agonist- specific in the manner in which it regulates platelet function. Using small molecule inhibitors selective for 12-LOX and 12-LOX-deficient mice, the role of 12-LOX in regulation of human platelet activation and thrombosis was investigated. Pharmacologically inhibiting 12-LOX resulted in attenuation of platel

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40

Vadasz, Zahava, Alexandra Balbir Gurman, Pierluigi Meroni, et al. "Lysyl oxidase—a possible role in systemic sclerosis–associated pulmonary hypertension: a multicentre study." Rheumatology 58, no. 9 (2019): 1547–55. http://dx.doi.org/10.1093/rheumatology/kez035.

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Abstract Objective Lysyl oxidase (LOX) is an extracellular enzyme that cross-links collagen fibrils. LOX was found to be increased in serum of SSc patients and was suggested to be related to skin fibrosis, yet a vascular source of LOX has been demonstrated in idiopathic pulmonary arterial hypertension (iPAH). We aimed to validate elevated LOX serum levels in SSc and to study its correlation with clinical characteristics and investigate its main source at the tissue level. Methods A total of 86 established SSc patients were compared with 86 patients with very early diagnosis of systemic scleros

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Sharma, Durga Shankar Shankar, Eliana Botta, Wan-Chen Tsai, Theodore Holman, and Michael Holinstat. "Non-Enzymatic Role of Platelet 12-LOX in Platelet Activation." Blood 142, Supplement 1 (2023): 5397. http://dx.doi.org/10.1182/blood-2023-182035.

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Background 12-lipoxygenase (12-LOX) plays an essential role in regulation of vascular disease and human platelet function through oxylipin generation such as 12-hydro(pero)xyeicosatetraenoic acid (12-H(P)ETE) and 12-hydroxyeicosatetraenoic acid (12-HETE). Previous literature has demonstrated that 12-LOX enzymatic function such as oxylipin generation is important for collagen- or thrombin-mediated signaling events. However, the addition of 12(S)-HETE does not completely restore the inhibitory effect of pharmacologically or genetically inhibiting 12-LOX on platelet activation, indicating that 12

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Li, Xing, Xiang-yuan Wu, Nan Jiang, Yan-Fang Xing, Jie Chen, and Qu Lin. "Endoplasmic reticulum stress induced Lox-1+ CD15+ polymorphonuclear myeloid-derived suppressor cells in hepatocellular carcinoma and associated with poor prognsis." Journal of Clinical Oncology 36, no. 5_suppl (2018): 38. http://dx.doi.org/10.1200/jco.2018.36.5_suppl.38.

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38 Background: A recent study indicated that Lectin-type oxidized LDL receptor-1 (LOX-1) was a distinct surface marker for human polymorphonuclears myeloid-derived suppressor cells (PMN-MDSC). The present study was aimed to investigate the existence LOX-1 PMN-MDSC in hepatocellular carcinoma (HCC) patients, the latent mechanism and their association with clinical parameters. Methods: 30 HCC patients and 30 health control were included. LOX-1+CD15+ PMN-MDSCs were investigated. Results: LOX-1+CD15+ PMN-MDSC were significantly elevated in both WB and PBMC of HCC patients compared with healthy con

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43

Lyman, Henry. "Lox et lex." Ocean Development & International Law 15, no. 1 (1985): 1–12. http://dx.doi.org/10.1080/00908328509545764.

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Sawamura, Tatsuya. "LOX-1 Unlocked." Structure 13, no. 6 (2005): 834–35. http://dx.doi.org/10.1016/j.str.2005.05.001.

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Idol, Walter D. "Looking into LOX." Journal of Air Medical Transport 9, no. 11 (1990): 18–21. http://dx.doi.org/10.1016/s1046-9095(05)80104-7.

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Hermonat, Paul L., Hongqing Zhu, Maohua Cao, and Jawahar L. Mehta. "LOX-1 Transcription." Cardiovascular Drugs and Therapy 25, no. 5 (2011): 393–400. http://dx.doi.org/10.1007/s10557-011-6322-8.

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Ikonomovic, Milos D., Eric E. Abrahamson, Tolga Uz, Hari Manev, and Steven T. DeKosky. "Increased 5-Lipoxygenase Immunoreactivity in the Hippocampus of Patients With Alzheimer's Disease." Journal of Histochemistry & Cytochemistry 56, no. 12 (2008): 1065–73. http://dx.doi.org/10.1369/jhc.2008.951855.

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The proinflammatory enzyme 5-lipoxygenase (5-LOX) is upregulated in Alzheimer's disease (AD), but its localization and association with the hallmark lesions of the disease, β-amyloid (Aβ) plaques and neurofibrillary tangles (NFTs), is unknown. This study examined the distribution and cellular localization of 5-LOX in the medial temporal lobe from AD and control subjects. The spatial relationship between 5-LOX immunoreactive structures and AD lesions was also examined. We report that, in AD subjects, 5-LOX immunoreactivity is elevated relative to controls, and its localization is dependent on t

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Trackman, Philip C., Yaser Peymanfar, and Sayon Roy. "Functions and Mechanisms of Pro-Lysyl Oxidase Processing in Cancers and Eye Pathologies with a Focus on Diabetic Retinopathy." International Journal of Molecular Sciences 23, no. 9 (2022): 5088. http://dx.doi.org/10.3390/ijms23095088.

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Lysyl oxidases are multifunctional proteins derived from five lysyl oxidase paralogues (LOX) and lysyl oxidase-like 1 through lysyl oxidase-like 4 (LOXL1–LOXL4). All participate in the biosynthesis of and maturation of connective tissues by catalyzing the oxidative deamination of lysine residues in collagens and elastin, which ultimately results in the development of cross-links required to function. In addition, the five LOX genes have been linked to fibrosis and cancer when overexpressed, while tumor suppression by the propeptide derived from pro-LOX has been documented. Similarly, in diabet

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Fu, Jian, Lili Cheng, Mei Liang, and Ping Zhang. "LOX-1 is a novel mediator of acute lung inflammation (94.10)." Journal of Immunology 182, no. 1_Supplement (2009): 94.10. http://dx.doi.org/10.4049/jimmunol.182.supp.94.10.

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Abstract Up-regulation of Lectin-like oxidized LDL receptor-1 (LOX-1) has been known to mediate oxidized LDL-induced vascular inflammation and atherogenesis. Even though there has been increasing evidence suggesting that LOX-1 may play an important role in chronic inflammation, the role of LOX-1 in acute inflammation and tissue injury remains largely unknown. In our present study, we assessed the role of LOX-1 in a mouse model of endotoxin-induced acute lung injury. We demonstrated that LOX-1 could act directly as a neutrophil adhesion molecule. Importantly, blockade of LOX-1 was able to inhib

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Perry, Steven C., Chakrapani Kalyanaraman, Benjamin E. Tourdot, et al. "15-Lipoxygenase-1 biosynthesis of 7S,14S-diHDHA implicates 15-lipoxygenase-2 in biosynthesis of resolvin D5." Journal of Lipid Research 61, no. 7 (2020): 1087–103. http://dx.doi.org/10.1194/jlr.ra120000777.

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The two oxylipins 7S,14S-dihydroxydocosahexaenoic acid (diHDHA) and 7S,17S-diHDHA [resolvin D5 (RvD5)] have been found in macrophages and infectious inflammatory exudates and are believed to function as specialized pro-resolving mediators (SPMs). Their biosynthesis is thought to proceed through sequential oxidations of DHA by lipoxygenase (LOX) enzymes, specifically, by human 5-LOX (h5-LOX) first to 7(S)-hydroxy-4Z,8E,10Z,13Z,16Z,19Z-DHA (7S-HDHA), followed by human platelet 12-LOX (h12-LOX) to form 7(S),14(S)-dihydroxy-4Z,8E,10Z,12E,16Z,19Z-DHA (7S,14S-diHDHA) or human reticulocyte 15-LOX-1 (

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