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Journal articles on the topic 'Loa (Spirits)'

Author: Grafiati

Published: 4 June 2021

Last updated: 4 February 2022

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1

Baird, Ian G. "The cult of Phaya Narin Songkhram: Spirit mediums and shifting sociocultural boundaries in northeastern Thailand." Journal of Southeast Asian Studies 45, no. 1 (January 10, 2014): 50–73. http://dx.doi.org/10.1017/s0022463413000593.

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Sociocultural boundaries come in many forms, and crucially, are responsive to power and constantly in flux. This article focuses on the production of space and unmarked sociocultural boundaries linked to spirit mediums in a historically contested area of northeastern Thailand who are possessed by the spirits of Phaya Narin Songkhram — a key ‘Lao’ military leader of Chao Anou's famous Vientiane revolt against Siam between 1826–28 — and those of his subordinates. Spirit mediums linked to ethnic ‘Thai’ leaders are also found to the south of this area. Through channeling and performing these historical persons, spirit mediums keep alive and reproduce group memories with space-making implications. This article also shows how the mediums' positioning has shifted over time and varies in relation to contemporary power relations, altering the sociocultural boundaries between ethnic Lao and Thai.

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2

Arduini, Silvia, Alessandro Zappi, Marcello Locatelli, Salvatore Sgrò, and Dora Melucci. "An Authentication Study on Grappa Spirit: The Use of Chemometrics to Detect a Food Fraud." Analytica 2, no. 3 (August 30, 2021): 84–92. http://dx.doi.org/10.3390/analytica2030010.

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An authenticity study on Italian grape marc spirit was carried out by gas chromatography (GC) and chemometrics. A grape marc spirit produced in Italy takes the particular name of “grappa”, a product which has peculiar tradition and production in its country of origin. Therefore, the evaluation of its authenticity plays an important role for its consumption in Italy, as well as for its exportation all around the world. For the present work, 123 samples of grappa and several kinds of spirits were analyzed in their alcohol content by electronic densimetry, and in their volatile fraction by gas-chromatography with a flame-ionization detector. Part of these samples (94) was employed as a training set to compute a chemometric model (by linear discriminant analysis, LDA) and the other part (29 samples) was used as a test set to validate it. Finally, two grappa samples seized from the market by the Italian Customs and Monopolies Agency and considered suspicious due to their aroma reported as non-compliant were projected onto the LDA model to evaluate the compliance with the “grappa” class. A further one-class classification method by principal component analysis (PCA) was carried out to evaluate the compliance with other classes. Results showed that the suspicious samples were not recognized as belonging to any of the analyzed spirit classes, confirming the starting hypothesis that they could be grappa samples adulterated in some way.

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3

Young-Scholten, Martha. "THE AGE FACTOR IN SECOND LANGUAGE ACQUISITION.David Singleton and Zsolt Lengyel. Philadelphia: Multilingual Matters, 1995. Pp. viii + 160." Studies in Second Language Acquisition 19, no. 3 (September 1997): 406–7. http://dx.doi.org/10.1017/s0272263197253052.

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The age issue has been with us for some time, and Singleton and Lengyel's six-paper volume indicates it will accompany us into the next millennium. In the L1A = L2A spirit of the 1970s, nonlinguistic accounts for age differences were offered. Yet if factors such as anxiety or ego permeability are responsible for lack of L2 success after a certain age, studies of postpuberty failure either point to the difficulty of reducing affective factors to prepuberty levels or, alternatively, offer support for a neurobiologically based Critical Period. These studies notwithstanding, it is helpful to return to the original question: Is the outcome of adult L2 acquisition always failure?

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4

Coats, Karen. "Teen Spirit by Francesca Lia Block." Bulletin of the Center for Children's Books 67, no. 5 (2014): 257–58. http://dx.doi.org/10.1353/bcc.2014.0039.

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5

Ataso, Chalermpol, and Pratompong Na Champasakdi. "Influence of Spiritualistic Belief on Musical Performance in Traditional Ritual: Mahesak City Guardian Ceremony in Champasak." Asian Culture and History 11, no. 1 (December 31, 2018): 23. http://dx.doi.org/10.5539/ach.v11n1p23.

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In early March, Mahesak city guardian ceremony is yearly held in Champasak, Lao People’s Democratic Republic to commemorate the city guardian spirits that were previously believed to protect Lao ancestors from unexplainable natural phenomena. Since the melody of music was believed to mediate the communication between human-beings and invisible city guardians, the sound of Piphat ensemble has become the heart of Mahesak ceremony. Therefore, in this study, the details of significance and religious implication of Mahesak ceremonial music via the sound of Piphat were elucidated. The variety in tunes and rhythms of Mahesak ceremonial songs exhibit the hierarchy of sacred sensations to worship different city guardians with the use of spiritual mediators as sequential representatives of each city guardian. These matters reflect the combination of primordial belief in guardian spirits amongst Lao people, despite the predominance of Buddhism in Lao People’s Democratic Republic nowadays.

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6

Hanousek-Cica, Karla, Martina Pezer, Jasna Mrvcic, Damir Stanzer, Jasna Cacic, Vesna Jurak, Mirela Krajnovic, and Jasenka Gajdos-Kljusuric. "Identification of phenolic and alcoholic compounds in wine spirits and their classification by use of multivariate analysis." Journal of the Serbian Chemical Society 84, no. 7 (2019): 663–77. http://dx.doi.org/10.2298/jsc190115020h.

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During the ageing period wine spirits are changing their color, chemical composition and sensory characteristics. These changes should be simply monitored. The aim of this study was to develop partial least squares regression (PLS) models for higher alcohols and phenols in wine spirits as well as to show the feasibility of the NIR spectroscopy combined with chemometric tools to distinguish wine spirits and brandies with different ageing degree. To get the reference values, the usual methods for the analysis of spirits drinks were used. Ethanol, esters, acids, methanol and higher alcohols were studied. Wine spirits and brandies phenol composition was determined by liquid chromatography. Principal component analysis (PCA) was used to classify the wine spirits and brandies according to their phenolic and higher alcohols composition. Moreover, the Partial least squares regression (PLS regression) was used to calibrate and predict expected contents of higher alcohols and phenols in the wine spirits. Success of the classification of samples by ageing based on individual alcohols was 93.8 %, while success of the classification based on individual phenols raised to 100 %. This efficiency of the prediction was evaluated by use of linear discriminator analysis (LDA).

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7

BEG, TASNIM MIRZA. "Luck, Lao Tzu, and the Spirit of Family Medicine." Family Practice News 42, no. 2 (February 2012): 19. http://dx.doi.org/10.1016/s0300-7073(12)70089-0.

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8

Rozenberg, Guillaume. "Spirits of the Place. Buddhism and Lao Religious Culture, John Clifford Holt." Moussons, no. 19 (June 15, 2012): 178–81. http://dx.doi.org/10.4000/moussons.1322.

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9

Uríčková, Veronika, Kinga Dobóová, and Jana Sádecká. "Distinguishing between juniper-flavoured spirit drinks from different producers." Nova Biotechnologica et Chimica 16, no. 2 (December 1, 2017): 132–37. http://dx.doi.org/10.1515/nbec-2017-0018.

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Abstract A simple method for classifying juniper-flavoured spirit drinks is proposed based on the ratio of fluorescence intensity values in synchronous fluorescence spectra. Receiver operating curves (ROC) and linear discriminant analysis (LDA) were used to compute the performance of the classification. Significant differences in the fluorescence intensity ratios (I316/I287 and I324/I287) observed in the spectra recorded using wavelength difference 10 nm were evaluated by ROC analysis to identify cutoff values that gave ideal AUCs equal to one, thus allowing for 100% correct classification of the samples according to producer criteria. LDA showed that drinks of different producers could be distinguished (100% correct classification) on the basis of their differences in the fluorescence intensity ratios (I323/I287, I324/I287, I316/I287 and I325/I287). These results show that complete synchronous spectra are not required to discriminate between producers. Instead of them, fluorescence intensity could be measured at selected wavelengths.

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10

Reidy, James. "Newman as a Master of the Spirit." Logos: A Journal of Catholic Thought and Culture 8, no. 4 (2005): 64–85. http://dx.doi.org/10.1353/log.2005.0038.

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11

Jo, Min Hwan. "A Study on the Crazy Spirit in Lao-Chuang's Zealotry." Journal of The Studies of Taoism and Culture 51 (November 30, 2019): 35–64. http://dx.doi.org/10.38113/jstc.2019.11.51.35.

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12

McLellan, Janet, and Marybeth White. "Social, Religious, and ‘Spirit-based’ Capital within Cambodian and Lao Buddhist Communities in Ontario." Studies in Religion/Sciences Religieuses 44, no. 2 (May 29, 2015): 160–77. http://dx.doi.org/10.1177/0008429815580781.

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While an extensive literature supports the correlation of social capital with newcomer adaptation and integration, few studies demonstrate the challenges faced by refugee communities with low levels of social and religious capital. Cambodian and Lao Buddhists in Ontario, Canada, have had significant resettlement struggles, particularly in their ability to re-create religious traditions and practices. Theravada Buddhist monks, who embody much of each community’s social and religious capital, face extensive adaptive modifications to meet the conflicting demands placed upon them. A new term, “spirit-based capital,” is introduced to present monastic interactions with the spirit world as a benefit for individual and community health and well-being. The predominant pneumacentric (spirit-centered) religiosity of first generation refugees suggests that spirit-based capital can play an important compensatory role for newcomers who lack other forms of social and religious capital.

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13

Martin, Ralph. "A New Pentecost?: Catholic Theology and “Baptism in the Spirit”." Logos: A Journal of Catholic Thought and Culture 14, no. 3 (2011): 17–43. http://dx.doi.org/10.1353/log.2011.0019.

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14

Jackson, Timothy F. "The Role of the Holy Spirit in Gerard Manley Hopkins's Poetry." Logos: A Journal of Catholic Thought and Culture 9, no. 1 (2006): 108–27. http://dx.doi.org/10.1353/log.2006.0006.

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15

Millare, Roland. "The Spirit of the Liturgical Movement: A Benedictine Renewal of Culture." Logos: A Journal of Catholic Thought and Culture 17, no. 4 (2014): 130–54. http://dx.doi.org/10.1353/log.2014.0038.

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16

Kovács, Attila G., Attila Szöllősi, Dániel Szöllősi, Ilona A. Panyik, László Nagygyörgy, Ágoston Hoschke, and Quang D. Nguyen. "Classification and Identification of Three Vintage Designated Hungarian Spirits by Their Volatile Compounds." Periodica Polytechnica Chemical Engineering 62, no. 2 (August 8, 2017): 175. http://dx.doi.org/10.3311/ppch.11078.

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The quality of fruit based spirits varies year to year; therefore, the identification of the vintage of a distilled alcoholic beverage is necessary, but requires highly sensitive analytics. The interpretation of the gathered data requires a well-adapted chemometric method. In this study, Hungarian apple, sour cherry and plum distillates (pálinka’s) from different vintages were analyzed, classified and identified using volatile composition analyzed by GC-MS. The fruit’s origin, fermentation technique and distillation were the same at all the fruits; the only differences in the samples were their vintages (2010, 2011 and 2012). Analysis of variance (ANOVA) and Linear discriminant analysis (LDA) was applied for classification and components’ identification related to the vintage effect. The samples were successfully classified (correct classification rate ranging from 75 to 100%), three components are found to be related to the vintage effect regardless the fruit type: propanol, butanol and ethyl-propionate. GC-MS data proved to be a promising tool for classification of fruit distillate vintages.

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17

Kumagai, Michio, and Warwick F. Vincent. "EXPERIENCE THE JAPANESE SPIRIT OF HOSPITALITY AT THE 2012 ASLO SUMMER MEETING." Limnology and Oceanography Bulletin 21, no. 1 (February 2012): 12–13. http://dx.doi.org/10.1002/lob.201221112.

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18

Wungkeeree, Bourin. "Self-Awareness of Luang Phrabang Laoness in Thailand: a case Study of Myth and Ritual." MANUSYA 11, no. 1 (2008): 91–105. http://dx.doi.org/10.1163/26659077-01101007.

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This article offers a study of Lao people who migrated from Luang Phrabang to settle in Thailand, especially at Amphoe Lom Kao and Lom Sak, Phetchabun Province and Amphoe Dan Sai, Loei Province. These migrants have maintained their self-awareness as Luang Phrabang Lao by transmitting their own folk literature— for instance, local legends and hero tales, and rituals. Such ethnic transmission has been interpreted as an important mechanism for ethnic maintenance. Repeatedly reproduced in a discourse of myth telling in the context of spirit offering rituals, this transmission helps the community realize and remember that they are from Luang Phrabang, Lanxang, which was once a prosperous Buddhist centre in ancient times.

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19

Wallenfang, Donald L. "Awaken, O Spirit: The Vocation of Becoming in the Work of Edith Stein." Logos: A Journal of Catholic Thought and Culture 15, no. 4 (2012): 57–74. http://dx.doi.org/10.1353/log.2012.0036.

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20

Ladwig, Patrice. "Ontology, materiality and spectral traces: Methodological thoughts on studying Lao Buddhist festivals for ghosts and ancestral spirits." Anthropological Theory 12, no. 4 (December 2012): 427–47. http://dx.doi.org/10.1177/1463499612471933.

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21

Vogel, Jeffrey A. "The Unselfing Activity of the Holy Spirit in the Theology of Hans Urs von Balthasar." Logos: A Journal of Catholic Thought and Culture 10, no. 4 (2007): 16–34. http://dx.doi.org/10.1353/log.2007.0037.

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22

Davenport, Nancy. "The Holy Spirit and the Soul as Revealed in Nature." Religion and the Arts 19, no. 3 (2015): 163–213. http://dx.doi.org/10.1163/15685292-01903001.

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The artist Anna Lea Merritt (1844–1930) was born in Philadelphia, Pennsylvania and spent most of her professional life in London and in a rural village in Surrey. She settled in England in 1871 and soon became a friend of the members of the Pre-Raphaelite Brotherhood in their mature years, the art critic John Ruskin, the late Victorian artists George Frederick Watts and Frederick, Lord Leighton, and others in the London artistic and literary community. In the milieu she had chosen, her intimate and spiritual relationship with nature and her sympathy for all mankind, ingrained in her in childhood among Unitarians and Quakers in Philadelphia, developed into paintings, murals, and etchings that were at once academic, naturalistic, and mystical. In re-introducing this little known woman artist today, this article focuses on her work as one that evokes the spirit and beauty of the natural world and sympathy for the plight of the suffering, both eloquent testimonials to the ideals and beliefs of her renowned friend and contemporary, John Ruskin and to late Victorian liberal sensibilities.

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23

Kedjierski, Walter F. "Papal Contributions to the Development of the Church's Missionary Spirit: From Ad Gentes to Evangelii Gaudium." Logos: A Journal of Catholic Thought and Culture 23, no. 1 (2020): 94–110. http://dx.doi.org/10.1353/log.2020.0004.

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24

Harmon, Thomas P. "Historicism Versus History and Spirit: Henri de Lubac on What We Can Learn from Studying Origen." Logos: A Journal of Catholic Thought and Culture 19, no. 3 (2016): 29–58. http://dx.doi.org/10.1353/log.2016.0026.

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25

Kedjierski, Walter F. "Papal Contributions to the Development of the Church's Missionary Spirit: From Ad Gentes to Evangelii Gaudium, Part I." Logos: A Journal of Catholic Thought and Culture 22, no. 4 (2019): 101–26. http://dx.doi.org/10.1353/log.2019.0031.

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26

Takdir, Mohammad. "NEW SPIRITUAL MOVEMENT: Menelisik Visi Transformatif Komunitas Lia Eden sebagai Embrio Lahirnya New Age di Indonesia." Jurnal THEOLOGIA 29, no. 1 (September 2, 2018): 1. http://dx.doi.org/10.21580/teo.2018.29.1.2415.

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<p class="Iabstrak"><strong>Abstract:</strong> <em>This research aims to explain the phenomenon of Lia Eden community which is a new spiritual movement in the dynamics of religious life in Indonesia. Some points to be described in this research are related with a background of the birth and development of the Lia Eden community, teaching, and transformative vision in the public sphere. This research is a case study of the Lia Eden community that became of the New Age movement in the wake of belief in formal religions that considered failure in overcoming the modern human crisis. This research shows that Lia Eden community is a new spiritual movement </em><em>who tried to awaken a spirit of all religions so that able to overcome of a social problem in society. This movement is not ambitions to establish a new religious institution with a strict and doctrinal organization, but effort to transmit spiritual power at the individual level to become a reflection of the mystical movement that brought changes to human life.</em></p><strong>Abstrak:</strong> Penelitian ini bertujuan untuk menjelaskan fenomena komunitas Lia Eden yang merupakan gerakan spiritualitas baru dalam dinamika kehidupan beragama di Indonesia. Beberapa poin yang ingin dijabarkan dalam penelitian ini adalah berkaitan dengan latar belakang kelahiran dan perkembangan komunitas Lia Eden, ajaran, dan visi transformatifnya dalam ruang publik. Penelitian ini merupakan studi kasus dari komunitas Lia Eden yang menjadi bagian dari Gerakan Zaman Baru (<em>New Age Movement</em>) di tengah memudarnya kepercayaan terhadap agama formal yang dianggap gagal dalam mengatasi krisis kemanusian modern. Penelitian ini menunjukkan bahwa komunitas Lia Eden merupakan gerakan spiritualitas baru yang berupaya membangkitkan roh dari semua agama agar berperan dalam mengatasi masalah sosial di masyarakat. Gerakan ini tidak berambisi untuk mendirikan institusi baru yang bersifat keagamaan dengan organisasi yang ketat dan bersifat doktrinal, melainkan berupaya untuk mentransmisikan kekuatan spiritual pada level individu hingga menjadi cerminan dari gerakan mistik yang membawa perubahan bagi kehidupan manusia.

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27

Das, Shankar P. "Lattice Gas Model with Nonlocal Interactions." International Journal of Modern Physics B 11, no. 30 (December 10, 1997): 3581–94. http://dx.doi.org/10.1142/s0217979297001799.

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We analyze the nature of the hydrodynamic modes in a Lattice Gas Automata (LGA) model defined on a hexagonal lattice and having nonlocal interactions of attractive and repulsive type simultaneously. The model is similar in spirit to the liquid gas model of Appert and Zaleski [Phys. Rev. Lett.64, 1 (1990)]. The phase diagram for the model is computed using the kinetic pressure. The dynamics is studied with a mean field type approach in the Boltzmann approximation ignoring effects of correlated collisions. We compute the transport coefficients and the speed of sound propagation. The presence of attractive interactions show increase in the transport coefficients at intermediate densities.

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28

Serra, Juan Pablo. "Buchmendel, or the Uniqueness of Human Spirit According to Stefan Zweig." Pensamiento y Cultura 16, no. 2 (December 1, 2013): 100–121. http://dx.doi.org/10.5294/pecu.2013.16.2.5.

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29

Bulatovic, Aleksandar. "Particular ceramic forms in the central Balkan and northern shores of the Aegean sea in the late bronze age." Starinar, no. 61 (2011): 121–40. http://dx.doi.org/10.2298/sta1161121b.

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This paper deals with the appearance and development of particular ceramic forms that were prevalent on the wider territory from the lower Danube to the northern shores of the Aegean sea during the middle and Late Bronze Age. These forms relate to globular beakers, pear shaped vessels with everted rims with arch shaped handles, cups with handles with plastic applications on their upper surface, etc. Particular attention is devoted to the phenomenon of globular beakers of the LBA in the valleys of Varder, Mesta and Struma rivers. All information collected primarily through analysis of stylistic-typological characteristics of ceramics of the middle and Late Bronze Age - that took into account ritual burials, layout of settlements, trade routes and climactic conditions during that period - points to population movements from the north to the south already by the LBA, i.e. in 15th century BC. These movements contributed to the creation of particular cultural groups in the LBA in the central Balkans, such as the Brnjica cultural group. However, these movements cannot be clearly linked to the so-called Aegean Migration, and for this reason their character and chronology are subject to debate. Ultimately it can be concluded that beakers of the Zimnicea -Cherkovna-Plovdiv type appeared in the late Bronze Age in the Vlasine depression and the Danube valley through the evolution of beaker forms of cultural groups of earlier periods. Almost contemporaneously, during LBA, a variant of this ceramic form, richly ornamented (mostly with spirals) and similar in manner to the cultural group Dubovac-Zuto Brdo-Grla Mare- Krna, appeared in the LBA culture in northern Greece. Clearly this stylistic mannerism, with spirals as characteristic elements, spread relatively quickly through successive migrations in the period of 15th-14th century BC, toward the south of the Balkan Peninsula, thus covering the wider territory from the southern tip of the Carpathian mountains down to the northern shores of the Aegean Sea. Participants in those migrations are in fact representatives of cultural groups that were created in the northern Balkan Peninsula during the 16th and 15th centuries BC through the breakdown of Vatic culture. As the result of pressures from the north and north-west they headed south, contributing to the creation and development of cultural groups on the territory of the central Balkans. The final destination of the migrations were the valleys of the Mesta, Struma and Vardar rivers where, starting in the 15th century BC, a noticeable foreign cultural influence can be felt that became most pronounced during 14th century BC.

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30

MCKNIGHT, DIANE M., KEVIN A. THORN, ROBERT L. WERSHAW, J. MICHAEL BRACEWELL, and GRAEME W. ROBERTSON. "Rapid changes in dissolved humic substances in Spirit Lake and South Fork Castle Lake, Washington." Limnology and Oceanography 33, no. 6_part_2 (1988): 1527–41. http://dx.doi.org/10.4319/lo.1988.33.6_part_2.1527.

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31

McKnight, Diane M., Kevin A. Thorn, Robert L. Wershaw, J. Michael Bracewell, and Graeme W. Robertson. "Rapid changes in dissolved humic substances in Spirit Lake and South Fork Castle Lake, Washington." Limnology and Oceanography 33, no. 6part2 (November 1988): 1527–41. http://dx.doi.org/10.4319/lo.1988.33.6part2.1527.

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32

Tappe, Oliver. "Spirits of the Place: Buddhism and Lao Religious Culture. By John Clifford Holt. Honolulu: Hawai‘i University Press, 2009. xiii, 348 pp. $58.00 (cloth)." Journal of Asian Studies 70, no. 2 (May 2011): 629–31. http://dx.doi.org/10.1017/s0021911811000799.

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33

Davis, Erik W. "John Clifford Holt, . Spirits of the Place: Buddhism and Lao Religious Culture. Honolulu: University of Hawai’i Press, 2009. xiii+348 pp. $58.00 (cloth)." Journal of Religion 90, no. 3 (July 2010): 428–30. http://dx.doi.org/10.1086/654868.

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34

Owens, William M. "Laos. Spirits of the place: Buddhism and Lao religious culture. By John Clifford Holt. Honolulu: University of Hawai‘i Press, 2009. Pp. 348. Photographs, Plates, Appendices, Notes, Bibliography, Index." Journal of Southeast Asian Studies 43, no. 1 (January 3, 2012): 199–201. http://dx.doi.org/10.1017/s0022463411000816.

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35

유강하. "A Study on the Animated film ‘Sen and Chihiro's Spirited Away’ from the point of view of Lao-tzu(老子)." 아시아문화연구 18, no. ll (May 2010): 183–210. http://dx.doi.org/10.34252/acsri.2010.18..007.

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36

Grossi, Giuliano, Raffaella Lanzarotti, and Jianyi Lin. "Robust Face Recognition Providing the Identity and Its Reliability Degree Combining Sparse Representation and Multiple Features." International Journal of Pattern Recognition and Artificial Intelligence 30, no. 10 (November 23, 2016): 1656007. http://dx.doi.org/10.1142/s0218001416560073.

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For decades, face recognition (FR) has attracted a lot of attention, and several systems have been successfully developed to solve this problem. However, the issue deserves further research effort so as to reduce the still existing gap between the computer and human ability in solving it. Among the others, one of the human skills concerns his ability in naturally conferring a “degree of reliability” to the face identification he carried out. We believe that providing a FR system with this feature would be of great help in real application contexts, making more flexible and treatable the identification process. In this spirit, we propose a completely automatic FR system robust to possible adverse illuminations and facial expression variations that provides together with the identity the corresponding degree of reliability. The method promotes sparse coding of multi-feature representations with LDA projections for dimensionality reduction, and uses a multistage classifier. The method has been evaluated in the challenging condition of having few (3–5) images per subject in the gallery. Extended experiments on several challenging databases (frontal faces of Extended YaleB, BANCA, FRGC v2.0, and frontal faces of Multi-PIE) show that our method outperforms several state-of-the-art sparse coding FR systems, thus demonstrating its effectiveness and generalizability.

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37

Smolen, J. S., F. Behrens, S. Liu Leage, C. Sapin, I. De La Torre, G. Meszaros, G. Schett, et al. "AB0841 TARGET OUTCOMES IN PsA: SIMULTANEOUS ACHIEVEMENT of ACR50-PASI100 AND BEYOND: INSIGHTS FROM SPIRIT-H2H AT WEEK 24." Annals of the Rheumatic Diseases 79, Suppl 1 (June 2020): 1726.2–1727. http://dx.doi.org/10.1136/annrheumdis-2020-eular.2884.

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Background:Psoriatic Arthritis (PsA) treatment should aim to achieve robust improvement of arthritis as well as control of extra-articular manifestations like the skin. SPIRIT-H2H evaluated the efficacy of ixekizumab (IXE) and adalimumab (ADA) in patients with active PsA and psoriasis, and naïve to biologic Disease-Modifying Anti-Rheumatic Drugs (bDMARDs). At week 24 (W24), IXE showed superiority to ADA in simultaneous achievement of ACR50 and PASI100 as well as significant improvement of treat-to-target and other extra-articular outcomes.Objectives:To examine and to compare PsA efficacy outcomes in patients beyond achievement of the primary endpoint of the SPIRIT-H2H trial at W24, irrespective of treatment allocation.Methods:All patients recruited had active PsA (defined as tender joint count ≥3/68, swollen joint count ≥3/66 and body surface area [BSA] ≥3%), and inadequate response to conventional synthetic (cs)-DMARDs. Patients were randomised 1:1 to open-label, assessor-blinded IXE or ADA. We conducted post-hoc analysis of SPIRIT-H2H (NCT03151551), categorizing patients into four independent groups based on the achievement of the primary outcome (ACR50 & PASI100), ACR50 only, PASI100 only or none of them after 24 weeks of treatment. Statistical analyses consisted of mixed model for repeated measurement and logistic regression models using non-response imputation.Results:At week 24, patients reaching simultaneously ACR50 and PASI100 had a statistically significant higher response in most treat-to-target endpoints than those meeting ACR50 only (p<0.05). In this latter group, a high response rate was observed in ACR70, MDA, DAPSA remission and PASI90 response (48.9%, 60.6%, 35.1%, 36.2%, respectively). In patients that did not achieve either ACR50 or PASI100, up to 1/3 of the patients did achieve ACR20, DAPSA score ≤14, or no physical impairment.Table.Efficacy Endpoints at W24ACR50 & PASI100ACR50 onlyPASI100 onlyNeither ACR50 nor PASI100n=181n=94n=121n=170ACR20100.0b,c100.053.734.7ACR7064.6a,b,c48.90.00.0MDA75.7a,b,c60.623.112.4VLDA32.6a,b,c13.83.31.8DAPSA LDA or Remission (≤14)92.3a,b,c81.943.028.8DAPSA Remission (≤4)44.8b,c35.16.62.4HAQ-DI score ≤0.575.7b,c64.930.627.4PASI75100.0a,c60.6100.037.1PASI90100.0a,c36.2100.014.7SF-36 PCS change from baseline§12.3±0.53b,c12.3±0.745.4±0.664.0±0.55Data are presented as %;§mean±standard error.ap<0.05 vs. ACR50 only;bp<0.05 vs. PASI100only;cp<0.05 vs. Neither ACR50 nor PASI100.ACR, American College of Rheumatology; DAPSA, Disease Activity in Psoriatic Arthritis; HAQ-DI, Health Assessment Questionnaire Disability Index; LDA, Low Disease Activity; MDA, Minimal Disease Activity; PASI, Psoriasis Area Severity Index; VLDA, Very Low Disease Activity.Nine patients with active PsO and BSA≥3% were assessed as PASI=0 at baseline, a medical inconsistency that was resolved using medical judgement. These patients were considered PASI100 responders if PASI=0 and BSA=0 at post baseline visits.Conclusion:Reflecting the complexity of PsA, different degrees of improvement were observed across all treat-to-target outcomes with greater improvements in patients that met ACR50 response regardless of skin resolution. These findings at week 24 need to be confirmed with a longer duration of treatment.Disclosure of Interests:Josef S. Smolen Grant/research support from: AbbVie, AstraZeneca, Celgene, Celltrion, Chugai, Eli Lilly, Gilead, ILTOO, Janssen, Novartis-Sandoz, Pfizer Inc, Samsung, Sanofi, Consultant of: AbbVie, AstraZeneca, Celgene, Celltrion, Chugai, Eli Lilly, Gilead, ILTOO, Janssen, Novartis-Sandoz, Pfizer Inc, Samsung, Sanofi, Frank Behrens Grant/research support from: Pfizer, Janssen, Chugai, Celgene, Lilly and Roche, Consultant of: Pfizer, AbbVie, Sanofi, Lilly, Novartis, Genzyme, Boehringer, Janssen, MSD, Celgene, Roche and Chugai, Soyi Liu Leage Shareholder of: Eli Lilly and Company, Employee of: Eli Lilly and Company, Christophe Sapin Shareholder of: Eli Lilly and Company, Employee of: Eli Lilly and Company, Inmaculada De La Torre Shareholder of: Eli Lilly and Company, Employee of: Eli Lilly and Company, Gabriella Meszaros Shareholder of: Eli Lilly and Company, Employee of: Eli Lilly and Company, Georg Schett Speakers bureau: AbbVie, BMS, Celgene, Janssen, Eli Lilly, Novartis, Roche and UCB, Laure Gossec Grant/research support from: Lilly, Mylan, Pfizer, Sandoz, Consultant of: AbbVie, Amgen, Biogen, Celgene, Janssen, Lilly, Novartis, Pfizer, Sandoz, Sanofi-Aventis, UCB, Andrew Ostor Consultant of: MSD, Pfizer, Lilly, Abbvie, Novartis, Roche, Gilead and BMS, Speakers bureau: MSD, Pfizer, Lilly, Abbvie, Novartis, Roche, Gilead and BMS, Bernard Combe Grant/research support from: Novartis, Pfizer, Roche-Chugai, Consultant of: AbbVie; Gilead Sciences, Inc.; Janssen; Eli Lilly and Company; Pfizer; Roche-Chugai; Sanofi, Speakers bureau: Bristol-Myers Squibb; Gilead Sciences, Inc.; Eli Lilly and Company; Merck Sharp & Dohme; Pfizer; Roche-Chugai; UCB, Filip van den Bosch Consultant of: AbbVie, Celgene Corporation, Eli Lilly, Galapagos, Janssen, Novartis, Pfizer, and UCB, Speakers bureau: AbbVie, Celgene Corporation, Eli Lilly, Galapagos, Janssen, Novartis, Pfizer, and UCB

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Rwezaura, Bart. "The Proposed abolition of de facto unions in Tanzania: a case of sailing against the social current." Journal of African Law 42, no. 2 (1998): 187–214. http://dx.doi.org/10.1017/s0021855300011827.

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In April, 1994, the Law Reform Commission of Tanzania (LRC) recommended,inter alia, that section 160 of the Law of Marriage Act (LMA), be repealed because it constitutes “an unnecessary encroachment [on] the sanctity of marriage and [is] contrary to the spirit of the Law of Marriage Act”. Subsection (1) of the offending section enacts a statutory presumption of marriage in favour of reputed de facto unions that have existed for a minimum of two years. Subsection (2) states that once the presumption is rebutted, the woman cohabitant and the children born of that union become legally entitled to apply to the court for economic support from the male partner. In these proceedings the court has similar jurisdiction as a divorce court, including the making of orders for the division of assets jointly acquired by the couple and the determination of who is to have custody of the children. In 1971 when section 160 was enacted, it was widely recognized that de facto unions had become a social fact which the law could not ignore. Hence, the decision to extend to these unions the same legal consequences that follow a formal dissolution of a legal marriage. However, in so doing the legislature had indirectly raised and yet left open a number of important questions that have continued to engage the minds of judges.

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Sholikhin, Muhammad. "BERBAGAI MASALAH KEBERAGAMAAN MASYARAKAT MODERN DALAM PERSPEKTIF DEKONSTRUKSI DAKWAH BERBASIS PSIKOLOGI SOSIAL." KOMUNIKA: Jurnal Dakwah dan Komunikasi 9, no. 1 (January 23, 2017): 1–19. http://dx.doi.org/10.24090/komunika.v9i1.827.

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In one hand, modernity has fastened the development of science and technology, but on the other hand, it also alienates humans from their own spirit, caused by their exaltation on their industrial products. The effects of such condition occur in the following social and psycho logical symptoms: dislocation, disorientation and relative deprivation in certain social groups. In this context, da’wa has to deal not only with halal haram, but also with religious aspects of society and makes them a guideline to be adjusted to religious teachings. Da’wa needs to concern more on the aspect of mass psychology, with the emphasis on the principle of laa Rayba fiih in applying Islam, pathological treatment, and prevention of social deviation, as a result of modernity and laissez faire indi vidualism. The call for implementing the principles of bil hikmah, mauidah hasanah and mujadalah bi ahsan represents da’wa in its transmission, transformation, and socialization stages. Transmission deals with physical ap proach, transformation with social approach, and socialization with psy chological approach. They all present the historical facts, social-nuanced fiqh, grounded law, as well as prophetic mysticism. Modernitas di satu sisi telah melahirkan perkembangan ilmu pengetahuan dan teknologi yang sangat pesat, namun di sisi lain juga menciptakan keterasingan manusia dari jiwanya sendiri (alienasi) terjadi karena manusia telah mempertuhankan hasil-hasil industri yang dihasilkan oleh tangan mereka sendiri. Kemajuan pembangunan dan perubahan perubahan sosial yang diakibatkannya telah menimbulkan gejala-gejala sosial-psikologis; dislokasi, disorientasi dan deprivasi relatif pada kelompok-kelompok sosial tertentu. Dalam konteks ini, dakwah dituntut tidak hanya berbicara tentang halal haram, tapi harus lebih menitikberatkan pada aspek keberagamaan masyarakat sebagai gejala psikologis yang layakdijadikan kerangka acuan, guna disesuaikan dengan “tuntunan” keberagamaan yang hanif/lurus. Dakwah perlu lebih concern pada lahan garap psikologi massa, penekanan laa rayba fiih dalam ber-Islam, penanganan patologis, dan penanggulangan deviasi sosial, sebagai akibat modernitas dan laissez faire individualism. Perintah dakwah bil hikmah, mauidah hasanah dan mujadalah bi ahsan merupakan corak dakwah dalam proses pentahapan transmisi, transformasi dan sosialisasi. Transmisi merupakan pendekatan d}ahiriyyah-kejasmanian; transformasi adalah pendekatan sosio logis berfenomena massa, dan sosialisasi adalah pendekatan psikologis. Itu semua menampilkan fakta-fakta sejarah, fakta fiqh bernuansa sosial, syariat yang membumi, sekaligus tasawuf ala Nabi.

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DeKeseredy, Walter. "Special Edition: Left Realism Today - Guest Editor’s Introduction." International Journal for Crime, Justice and Social Democracy 5, no. 3 (September 1, 2016): 1. http://dx.doi.org/10.5204/ijcjsd.v5i3.346.

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Since its birth in the mid-1980s, as a major variant of critical criminology, Left Realism continues to ebb and flow. Furthermore, not all Left realist contributions are alike and some are subject to very heated debates. The fact remains, however, that Left Realism is ‘alive and well’. Of course, given that I devoted 26 years of my life (much of it with Martin D Schwartz) to the realist project, I could easily be accused of being biased. Nonetheless, some contemporary empirical support for my claim is the recent publication of Roger Matthews’ (2014) book Realist Criminology. The main objective of this volume is to use this offering as a ‘launching pad’ or ‘springboard’ for broader analyses of the relevance of Left Realism to critical criminology as we know it today. Matthews’ piece is the lead article. Following this are six others that, in part, address his monograph and that also point us to new directions in Left realist ways of knowing. In keeping with the spirit of the International Journal of Crime, Justice and Social Democracy, the authors constitute an international cadre of progressive scholars, including me, Joseph Donnermeyer, Steve Hall, Russell Hogg, John Lea, Claire Renzetti, and Simon Winlow. It cannot be emphasized enough, though, that this special issue is not a ‘love-in’ and there is no ‘party line’ here. All of the authors have strong positions on topics of major concern to academics and activists seeking new ways of thinking critically about crime, law and social control.

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Nepal, Pashupati. "Mainstreaming climate change adaptation into sectoral policies in Nepal: A review." Geographical Journal of Nepal 12 (April 1, 2019): 1–24. http://dx.doi.org/10.3126/gjn.v12i1.23412.

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Nepalese people have experienced climate variability for a long time and the mitigation and adaptation responses they have made to reduce the effect of climate variability are not new phenomena for Nepal. However, mainstreaming climate change issues into sectoral policies from the government can be seen as recent activities in Nepal. Nepal has contributed negligible amount of emissions of Greenhouse Gases (GHGs) of global greenhouse gas, it is the fourth most vulnerable country in the world. In this context, this paper aims to review climate change adaptation policies in terms of sectoral integration. This paper has adopted text-mining method for information retrieval and knowledge mining and followed step-by-step approach to undertake review of policies. It concludes that National Adaptation Programme of Action (NAPA) in 2010 can be a milestone in sectoral adaptation of climate change issue largely because it has provided the national framework for sectoral adaptation to climate change. However, NAPA ignores the importance of structural and institutional reforms needed for mainstreaming climate change adaptation into sectoral agencies. Climate change Policy, 2011, Local Adaptation Plan of Action (LAPA) 2011, Constitution of Nepal, 2015, Local Government Operation Act (LGOA) 2017, Disaster Risk Reduction and Management Act, 2017 and National REDD+ Strategy, 2018 are other prominent legislative and policy frameworks that have significant contribution in sectoral integration of climate change adaptation issues. However, lack of climate change act in order to implement fully these policies into practice for its implementation can be a major obstacle to achieve the goal. In this context, strong legislative foundation with effective institutional mechanism among different sectors will be very crucial to capture the spirit of new Federal Constitution of Nepal.

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Babicheva, Maya. "“Twice Crowned” (Leonid Yuzefovich – Laureate of the Big Book)." Stephanos Peer reviewed multilanguage scientific journal 47, no. 3 (May 31, 2021): 86–97. http://dx.doi.org/10.24249/2309-9917-2021-47-3-86-97.

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The article discusses the two-aspect nature of the contribution of L.A. Yuzefovich into Russian culture, as a reflection of the specifics of his gift. The criterion for the writer’s achievements was chosen to be a double leader in the national literary prize «Big Book» (a unique case in its history). The purpose of the article is to show the genre specificity of the individual style of Yuzefovich, which doubled the significance of his works for Russian literature and culture in general. The well-known Bulgakovʼs metaphor is applicable to the work of this writer completely. In this case, the right and left hand of the pianist can be considered fiction and documentary proze. A writer’s achievements in each of these areas greatly contribute to his success in the other. The leading place in the work of Yuzefovich the fiction writer is occupied by a large epic form. His novels with criminal plot, as a rule, have a pronounced detective line. The action takes place in different eras in different locations. These are Moscow and Western Europe of the 17th century, imperial Petersburg of the late 19th – early 20th centuries, Perm in the 1920s., etc. Specific historical details are reproduced in detail, the atmosphere of the era is recreated. Critics have repeatedly noted the writer’s ability to convey the spirit of the times in artistic form. The documentary prose of this author is a continuation of his scientific career (he is PhD in historical sciences). The beginning of this direction in his work was laid by the artistically revised dissertation research of the scientist. Subsequently, the main interest of Yuzefovich as the author of documentary proze focused on the events of the Civil War in Siberia and the Far East. The writer’s historical books have a fascinating plot and are written in good literary language. The best (to date) works of Yuzefovich of each of the named directions were awarded the Big Book Prize (the 1st place), awarded for a significant contribution to Russian culture and increasing the social significance of Russian literature. These are the novel «Cranes and the Dwarfs» (prize 2009) and the documentary novel «Winter Road» (prize 2015). Both works reveal important stages in Russian history and, at the same time, deserve high praise for their artistic form.

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Jacobson, Estelle, Jim Dreaver, Richard Miller, and Donna Martin. "*Wherever You Go There You Are: Mindfulness Meditation in Everyday Life – Jon Kabat-Zinn *How Yoga Works: An Introduction to Somatic Yoga – Elenor Criswell *Vanda Scaravelli on Yoga – Esther Meyers *Grace Unfolding: Psychotherapy in the Spirit of the Tao-Te Ching – Greg Johanson & Ron Kurtz *Interview with Ron Kurtz – Donna Martin *30 Scripts for Relaxation, Imagery and Inner Healing Volumes I & 2 – Julie T. Lusk." International Journal of Yoga Therapy 6, no. 1 (January 1, 1995): 46–59. http://dx.doi.org/10.17761/ijyt.6.1.3g081728271536v6.

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*Jon Kabat-Zinn whose latest book, 'Wherever You Go There You Are", has become a best seller and which teaches stress reduction through meditation and Yoga. *When I came across Eleanor Criswell's book I had already been a yoga devotee for many years, and more recently a student of somatic education, Naturally, I was interested in Dr. Criswell's "somatic" perspective on yoga, and how it was different from traditional yoga. *I always take great pleasure in witnessing people who are at the top of their art form, be it music, painting, dance, therapy, meditation, yoga-whatever. The important factor is that they are living their art form in a truly magnificent manner-when they are not only performing what they have mastered, but they have become it. *Ron Kurtz, who developed the Hakomi Method of body-centered psychotherapy, and Greg Johanson, senior trainer of the Hakomi Institute, have written this book to illustrate the connection between the ancient principles of the Tao-Te Ching, Lao Tzu's Chinese classic, and modem psychotherapy. Written for both therapists and clients, it addresses issues of non-violence, the use of the body in therapy, the importance of mindfulness, and the interrelatedness of all things. The introduction suggests that the reader approach the book in a meditative way and "explore whatever enters your awareness." *Julie Lusk, yoga teacher, counselor and wellness expert has pulled together in these two volumes a variety of scripts that are useful to anyone in a teaching or helping profession. Her experience and expertise come through strongly in the introductory comments when she talks about preparing people correctly to make the experience safe and comfortable, creating the right atmosphere, using the voice effectively, and using music properly.

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Mazzei, P., A. Marino, R. Rampazzo, H. Plana, M. Rosado, and L. Arias. "Galaxy evolution in groups." Astronomy & Astrophysics 610 (February 2018): A8. http://dx.doi.org/10.1051/0004-6361/201731182.

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Context. Local Group (LG) analogs (LGAs) are galaxy associations dominated by a few bright spirals reminiscent of the LG. The NGC 3447/NGC 3447A system is a member of the LGG 225 group, a nearby LGA. This system is considered a physical pair composed of an intermediate-luminosity late-type spiral, NGC 3447 itself, and an irregular companion, NGC 3447A, linked by a faint, short filament of matter. A ring-like structure in the NGC 3447 outskirts has been emphasised by Galaxy Evolution Explorer (GALEX) observations. Aims. This work aims to contribute to the study of galaxy evolution in low-density environments, a favourable habitat to highly effective encounters, shedding light on the evolution of the NGC 3447/NGC 3447A system. Methods. We performed a multi-λ analysis of the surface photometry of this system to derive its spectral energy distribution and structural properties using ultraviolet (UV), Swift UVOT, and optical Sloan Digital Sky Survey (SDSS) images complemented with available far-IR observations. We also characterised the velocity field of the pair using two-dimensional Hα kinematical observations of the system obtained with PUMA Fabry-Perot interferometer at the 2.1 m telescope of San Pedro Mártir (Mexico). All these data are used to constrain smooth particle hydrodynamic simulations with chemo-photometric implementation to shed light on the evolution of this system. Results. The luminosity profiles, from UV to optical wavelengths, are all consistent with the presence of a disc extending and including NGC 3447A. The overall velocity field does not emphasise any significant rotation pattern, rather a small velocity gradient between NGC 3447 and NGC 3447A. Our simulation, detached from a large grid explored to best-fit the global properties of the system, suggests that this arises from an encounter between two halos of equal mass. Conclusions. NGC 3447 and NGC 3447A belong to the same halo, NGC 3447A being a substructure of the same disk including NGC 3447. The halo gravitational instability, enhanced by the encounter, fuels a long-lived instability in this dark-matter-dominated disk, driving the observed morphology. The NGC 3447/NGC 3447A system may warn of a new class of “false pairs” and the potential danger of a misunderstanding of such objects in pair surveys that could produce a severe underestimate of the total mass of a system.

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Yang, L., and Y. Tian. "Chinese spirits consumption is an independent risk factor of left atrial appendage thrombosis in non-valvular atrial fibrillation patients." European Heart Journal 41, Supplement_2 (November 1, 2020). http://dx.doi.org/10.1093/ehjci/ehaa946.0484.

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Abstract Background Alcohol consumption is often associated with an increased risk of atrial fibrillation; however, its association with left atrial appendage (LAA) thrombosis in patients with non-valvular atrial fibrillation (NVAF) remains undefined. Purpose To investigate the relationship between Chinese spirits consumption and LAA thrombosis in NVAF patients. Methods 504 consecutive adult patients with NVAF undergoing first radiofrequency catheter ablation who were enrolled retrospectively from January 2016 to April 2019. LAA thrombosis was identified by transesophageal echocardiography before catheter ablation. Risk factors for LAA thrombosis were determined by uni-/multivariate analysis of data derived from a questionnaire on alcohol consumption and other risk factors for AF, and biochemical and imaging information. Results Of the 504 patients studied, 86 (17.1%) had a drinking habit, and 59 patients (11.7%) had LAA thrombosis. The proportion of alcohol drinking patients was 47.5% (28/59) in the thrombosis group and 12.7% (58/455) in the non-thrombosis group (P<0.001). In multivariate analysis, Chinese spirits consumption (≥12g daily; OR 15.025, 95% CI 6.123–36.815, P<0.001), non-paroxysmal AF (OR 8.301, 95% CI 3.946–17.460, P<0.001), AF duration (OR 1.019, 95% CI 1.010–1.027, P<0.001), CHA2DS2-VASc score (OR 2.078, 95% CI 1.625–2.658, P<0.001), and effective anticoagulation (OR 0.348, 95% CI 0.132–0.921, P=0.033) were independently associated with LAA thrombosis. Conclusions Chinese spirits consumption was independently associated with LAA thrombosis in NVAF patients. Whether avoiding alcohol consumption might reduce the occurrence of LAA thrombosis and thromboembolism in NVAF patients requires further study. Funding Acknowledgement Type of funding source: None

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"Spirits of the place: Buddhism and Lao religious culture." Choice Reviews Online 47, no. 08 (April 1, 2010): 47–4358. http://dx.doi.org/10.5860/choice.47-4358.

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Vera-Aranda, Ángel Luis. "Teaching to watch television with a critical spirit." Comunicar 16, no. 31 (October 1, 2008). http://dx.doi.org/10.3916/c31-2008-03-060.

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Young people spend more time watching television than attending classes at school. However, violent, aggressive or just clearly harmful programmes are broadcast for the minors more and more often every day. Faced with the lack of real self-regulation on the part of operators, it is necessary that the administration takes definitely measures in this respect. A possible solution can be found by implementing projects of media literacy, which have not been carried out in our country yet, although they are quite frequent in the most developed countries in Europe and America. Los jóvenes dedican más tiempo a ver la televisión que a asistir a clase en un centro educativo. Sin embargo, los contenidos televisivos que se emiten tienen cada vez una carga mayor de violencia, de agresividad o de pautas que son claramente perjudiciales para los menores de edad. Ante la falta de una verdadera autorregulación por parte de los operadores, es necesario que la administración tome decididamente medidas al respecto. Una posibilidad de solución se encuentra en la puesta en práctica de proyectos de alfabetización mediática, que aunque son bastante frecuentes en los países más avanzados de Europa y de América, aún no han sido llevados a cabo en nuestro país.

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Shan, Li Cun. "30 Characteristics of Chinese Philosophy and the Chinese National Spirit." Yearbook for Eastern and Western Philosophy 2016, no. 1 (January 25, 2016). http://dx.doi.org/10.1515/yewph-2016-0032.

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AbstractHumanistic and ethical thought existed in China already in the ancient culture period, and was strongly enhanced during the Spring and Autumn era. Based on this background and foundation, Confucius is ‘a creator of the paradigm’ of Chinese philosophy, and Lao-Tzu is ‘an original metaphysician,’ both establishing the basic tendencies of Chinese philosophy. After that, the philosophies of pre- and post-Qin eras, all continued to develop along their thought. Chinese philosophy has several characteristics, including the unity of nature and man, truth and goodness, cognition and behavior, ontology and cosmology, humanity and natural law, the theory of human nature and values and many others. Its theoretic framework and basic structure aims to enlighten what humans ought to be - a question at the core of Chinese culture, reflecting the national spirit. The Chinese spirit is paradigmatically expressed in two sayings, “as Heaven’s movement is ever vigorous, so must a gentleman ceaselessly strive,” and “as Earth is broad and profound, so must a gentleman be greatly virtuous and lenient.”

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Coates, Laura C., Julie Birt, Andris Kronbergs, Rebecca Bolce, Andrew J. Bradley, So Young Park, and Philip S. Helliwell. "P172 Quality of life improvements in patients with PsA who achieve remission or low disease activity targets: results from two clinical trials of ixekizumab at three years of treatment." Rheumatology 60, Supplement_1 (April 1, 2021). http://dx.doi.org/10.1093/rheumatology/keab247.167.

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Abstract Background/Aims Treatment guidelines suggest a treat-to-target strategy using remission or low disease activity (LDA) targets in psoriatic arthritis (PsA). For patients with PsA, target achievement is associated with significantly improved quality of life (QoL). This analysis examined physical function and QoL improvements in PsA patients achieving remission or LDA targets at 3 years (156 weeks) of treatment with ixekizumab, a high-affinity monoclonal antibody selectively targeting interleukin-17A. Methods This study used integrated data from 2 double-blind, randomized phase 3 clinical trials (SPIRIT-P1, NCT01695239; SPIRIT-P2, NCT02349295) of ixekizumab-treated PsA patients who entered the extension period (N = 410). QoL outcome measures included HAQ-Disability Index (HAQ-DI), 36-Item Short-Form Health Survey Physical Component Score (SF-36 PCS), and the 5-level EQ-5D Visual Analogue Scale (EQ-5D-5L VAS). Remission or LDA targets included minimal disease activity (MDA), very low disease activity (VLDA), Disease Activity in Psoriatic Arthritis (DAPSA) remission, DAPSA LDA, Psoriatic Arthritis Disease Activity Score (PASDAS) LDA, and PASDAS VLDA. The response rate (%) of patients achieving minimal clinically important differences (MCID RR) for measures with defined MCID and changes from baseline (CFB) for EQ-5D-5L VAS were observed. QoL improvements by remission or LDA target response status were assessed; significance was calculated by Fisher’s exact test for MCID RR and one-way analysis of variance for CFB. Missing data were imputed by non-responder imputation and modified baseline observation carried forward for binary and continuous measures, respectively. Results At 3 years of treatment, the percentage of responders was 34.6% (n/N=142/410), 16.1% (n/N=66/410), 48.8% (n/N=200/410), 23.4% (n/N=96/410), 40.5% (n/N=166/410), and 20.7% (n/N=85/410) for MDA, VLDA, DAPSA LDA, DAPSA remission, PASDAS LDA, and PASDAS VLDA, respectively. Achievement of VLDA, DAPSA remission, and PASDAS VLDA were significantly associated with the most QoL improvement, more than achievement of MDA, DAPSA LDA, and PASDAS LDA, which were significantly associated with more QoL improvement than target nonachievement (Table). P172 Table 1:Association of Patients Achieving Remission or Low Disease Activity Targets with Incremental QoL Improvement at 3 Years.(1) Did not achieve MDA or VLDA(2) MDA but not VLDA(3) Achieved VLDAHAQ-DI MCID RRResponse, % (n/N)16.3 (40/246)83.1 (54/65)94.4 (51/54)Difference vs. (1), % (95% CI)–66.8 (56.6, 77.0) ‡78.2 (70.5, 85.8) ‡Difference vs. (2), % (95% CI)––11.4 (0.39, 22.3)SF-36 PCS MCID RRResponse, % (n/N)27.2 (73/268)80.3 (61/76)86.4 (57/66)Difference vs. (1), % (95% CI)–53.0 (42.6, 63.4) ‡59.1 (49.3, 69.0) ‡Difference vs. (2), % (95% CI)––6.1 (-6.1, 18.3)EQ-5D-5L VAS CFBNx2617463Mean (SD)7.5 (21.1)17.2 (22.7)28.0 (22.1)Mean Difference vs. (1), (95% CI)–9.7 (4.2, 15.3) ‡20.5 (14.7, 26.4) ‡Mean Difference vs. (2), (95% CI)––10.8 (3.3, 18.3)†(1) Did not achieve DAPSA LDA or DAPSA remission(2) DAPSA LDA but not remission(3) Achieved DAPSA remissionHAQ-DI MCID RRResponse, % (n/N)8.9 (17/191)60.4 (55/91)88.0 (73/83)Difference vs. (1), % (95% CI)–51.5 (40.7, 62.4) ‡79.1 (71.0, 87.1) ‡Difference vs. (2), % (95% CI)––27.5 (15.3, 39.8) ‡SF-36 PCS MCID RRResponse, % (n/N)15.2 (32/210)72.1 (75/104)87.5 (84/96)Difference vs. (1), % (95% CI)–56.9 (47.0, 66.8) ‡72.3 (64.1, 80.5) ‡Difference vs. (2), % (95% CI)––15.4 (4.5, 26.3) †EQ-5D-5L VAS CFBNx20510192Mean (SD)5.6 (20.8)15.9 (21.1)24.4 (23.5)Mean Difference vs. (1), (95% CI)–10.4 (5.4, 15.3) ‡18.8 (13.5, 24.1) ‡Mean Difference vs. (2), (95% CI)––8.4 (2.1, 14.7)†(1) Did not achieve PASDAS LDA or VLDA(2) PASDAS LDA but not VLDA(3) Achieved PASDAS VLDAHAQ-DI MCID RRResponse, % (n/N)15.3 (34/223)63.2 (43/68)91.9 (68/74)Difference vs. (1), % (95% CI)–48.0 (35.6, 60.4) ‡76.7 (68.8, 84.5) ‡Difference vs. (2), % (95% CI)––29.7 (15.6, 41.7) ‡SF-36 PCS MCID RRResponse, % (n/N)22.1 (54/244)75.3 (61/81)89.4 (76/85)Difference vs. (1), % (95% CI)–53.2 (42.4, 63.9) ‡67.3 (58.9, 75.6) ‡Difference vs. (2), % (95% CI)––14.1 (2.7, 25.6)*EQ-5D-5L VAS CFBNx2387882Mean (SD)6.2 (21.1)15.8 (19.9)27.7 (22.8Mean Difference vs. (1), (95% CI)–9.5 (4.2, 14.9) ‡21.5 (16.1, 26.9) ‡Mean Difference vs. (2), (95% CI)––11.9 (5.3, 18.6) ‡Negative changes from baseline indicate improvement in HAQ-DI. Positive changes from baseline indicate improvement in SF-36 PCS and EQ-5D-5L VAS. The MCID for HAQ-DI is defined as a CFB ≤-0.35. The MCID for SF-36 PCS is defined as a CFB ≥2.5. DAPSA LDA refers to a DAPSA score >4 but ≤14; DAPSA remission refers to a DAPSA score ≤4. PASDAS LDA refers to a PASDAS score >1.9 but ≤3.2; PASDAS VLDA refers to a PASDAS score ≤1.9.EQ-5D-5L VAS is measured on a scale of 1-100. Missing data were imputed by NRI for MCID (HAQ-DI and SF-36 PCS) and mBOCF for CFB (EQ-5D-5L VAS). P values were calculated by Fisher’s exact test for MCID RR (HAQ-DI and SF-36) and one-way ANOVA for CFB (EQ-5D);*p < 0.05;†p < 0.01;‡p < 0.001. ANOVA=analysis of variance; CFB= change from baseline; CI=confidence interval; DAPSA=Disease Activity in Psoriatic Arthritis; EQ-5D-5L VAS=5-Level EQ-5D Visual Analog Scale; HAQ-DI= Health Assessment Questionnaire-Disability Index; MCID RR=minimal clinically important difference response rate (%); LDA=low disease activity; mBOFC=modified baseline observation carried forward; MDA=minimal disease activity; n=number of patients achieving QoL measure; N=number of patients in subgroup; NRI=non-responder imputation; Nx=number of patients with non-missing data; PASDAS=Psoriatic Arthritis Disease Activity Score; QoL=quality of life; SD=standard deviation; SF-36 PCS=36-Item Short-Form Health Survey Physical Component Score; VLDA=very low disease activity. Conclusion Significant associations between remission or LDA target achievement and QoL improvements were present at 3 years of ixekizumab treatment. Numerical improvements in HAQ-DI and SF-36 PCS appear greater in patients achieving the lowest targets; achieving the lowest targets shows incremental QoL benefits compared to achieving LDA. Disclosure L.C. Coates: Consultancies; Laura Coates has received honoraria, grant/research support or consulting fees from AbbVie, Amgen, Boehringer-Ingelheim, BMS, Celgene, Eli Lilly, Janssen, MSD, Novartis, Pfizer, Sun Pharma, and UCB. Honoraria; Laura Coates has received honoraria, grant/research support or consulting fees from AbbVie, Amgen, Boehringer-Ingelheim, BMS, Celgene, Eli Lilly, Janssen, MSD, Novartis, Pfizer, Sun Pharma, and UCB. Member of speakers’ bureau; Laura Coates is a member of a speakers' bureau for AbbVie, Amgen, Biogen, BMS, Celgene, Eli Lilly, Janssen, Medac, Novartis, Pfizer, Sun Pharma, and UCB. Grants/research support; Laura Coates has received honoraria, grant/research support or consulting fees from AbbVie, Amgen, Boehringer-Ingelheim, BMS, Celgene, Eli Lilly, Janssen, MSD, Novartis, Pfizer, Sun Pharma, and UCB. J. Birt: Other; Julie Birt is an employee and shareholder of Eli Lilly and Company. A. Kronbergs: Other; Andris Kronbergs is an employee and shareholder of Eli Lilly and Company. R. Bolce: Other; Rebecca Bolce is an employee and shareholder of Eli Lilly and Company. A.J. Bradley: Other; Andrew J. Bradley is an employee and shareholder of Eli Lilly and Company. S. Park: Other; So Young Park is an employee and shareholder of Eli Lilly and Company. P.S. Helliwell: Consultancies; Philip Helliwell has received honoraria/consultation fees paid to university from Eli Lilly and Pfizer and paid to self from Celgene, Janssen, and Eli Lilly. Honoraria; Philip Helliwell has received honoraria/consultation fees paid to university from Eli Lilly and Pfizer and paid to self from Celgene, Janssen, and Eli Lilly. Grants/research support; Philip Helliwell has received grants and research support paid to charity by Novartis.

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Jin, Zhang, Weng Zhangwen, and Ni Naichen. "Helping consumers to overcome information overload with a diversified online review subset." Frontiers of Business Research in China 13, no. 1 (September 24, 2019). http://dx.doi.org/10.1186/s11782-019-0062-1.

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Abstract Redundant online reviews often have a negative impact on the efficiency of consumers’ decision-making in their online shopping. A feasible solution for business analytics is to select a review subset from the original review corpus for consumers, which is called review selection. This study aims to address the diversified review selection problem, and proposes an effective review selection approach called Simulated Annealing-Diversified Review Selection (SA-DRS) that considers the semantic relationship of review features and the content diversity of selected reviews simultaneously. SA-DRS first constructs a feature taxonomy by utilizing the Latent Dirichlet Allocation (LDA) topic model and the Word2vec model to measure the topic relation and word context relation. Based on the established feature taxonomy, the similarity between each pair of reviews is defined and the review quality is estimated as well. Finally, diversified, high-quality reviews are selected heuristically by SA-DRS in the spirit of the simulated annealing method, forming the selected review subset. Extensive experiments are conducted on real-world e-commerce platforms to demonstrate the effectiveness of SA-DRS compared to other extant review selection approaches.

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