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Journal articles on the topic 'Local feedback regulation'

Author: Grafiati

Published: 4 June 2021

Last updated: 3 February 2022

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1

Taghvafard, Hadi, Alexander Medvedev, Anton V. Proskurnikov, and Ming Cao. "Impulsive model of endocrine regulation with a local continuous feedback." Mathematical Biosciences 310 (April 2019): 128–35. http://dx.doi.org/10.1016/j.mbs.2019.02.006.

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2

Takeda, S., C. Gapper, H. Kaya, E. Bell, K. Kuchitsu, and L. Dolan. "Local Positive Feedback Regulation Determines Cell Shape in Root Hair Cells." Science 319, no. 5867 (2008): 1241–44. http://dx.doi.org/10.1126/science.1152505.

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Miao, Zhixin, and Lingling Fan. "Achieving Economic Operation and Secondary Frequency Regulation Simultaneously Through Local Feedback Control." IEEE Transactions on Power Systems 32, no. 1 (2017): 85–93. http://dx.doi.org/10.1109/tpwrs.2016.2544847.

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4

Taghvafard, Hadi, Anton V. Proskurnikov, and Ming Cao. "Local and global analysis of endocrine regulation as a non-cyclic feedback system." Automatica 91 (May 2018): 190–96. http://dx.doi.org/10.1016/j.automatica.2018.01.035.

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Walker, J. J., F. Spiga, R. Gupta, Z. Zhao, S. L. Lightman, and J. R. Terry. "Rapid intra-adrenal feedback regulation of glucocorticoid synthesis." Journal of The Royal Society Interface 12, no. 102 (2015): 20140875. http://dx.doi.org/10.1098/rsif.2014.0875.

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The hypothalamic–pituitary–adrenal axis is a vital neuroendocrine system that regulates the secretion of glucocorticoid hormones from the adrenal glands. This system is characterized by a dynamic ultradian hormonal oscillation, and in addition is highly responsive to stressful stimuli. We have recently shown that a primary mechanism generating this ultradian rhythm is a systems-level interaction where adrenocorticotrophin hormone (ACTH) released from the pituitary stimulates the secretion of adrenal glucocorticoids, which in turn feedback at the level of the pituitary to rapidly inhibit ACTH s

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Song, Yohan, Anping Xia, Hee Yoon Lee, Rosalie Wang, Anthony J. Ricci, and John S. Oghalai. "Activity-dependent regulation of prestin expression in mouse outer hair cells." Journal of Neurophysiology 113, no. 10 (2015): 3531–42. http://dx.doi.org/10.1152/jn.00869.2014.

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Prestin is a membrane protein necessary for outer hair cell (OHC) electromotility and normal hearing. Its regulatory mechanisms are unknown. Several mouse models of hearing loss demonstrate increased prestin, inspiring us to investigate how hearing loss might feedback onto OHCs. To test whether centrally mediated feedback regulates prestin, we developed a novel model of inner hair cell loss. Injection of diphtheria toxin (DT) into adult CBA mice produced significant loss of inner hair cells without affecting OHCs. Thus, DT-injected mice were deaf because they had no afferent auditory input des

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Wilde, C. J., C. V. P. Addey, L. M. Boddy, and M. Peaker. "Autocrine regulation of milk secretion by a protein in milk." Biochemical Journal 305, no. 1 (1995): 51–58. http://dx.doi.org/10.1042/bj3050051.

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Frequency or completeness of milk removal from the lactating mammary gland regulates the rate of milk secretion by a mechanism which is local, chemical and inhibitory in nature. Screening of goat's milk proteins in rabbit mammary explant cultures identified a single whey protein of M(r) 7600 able to inhibit synthesis of milk constituents. The active whey protein, which we term FIL (Feedback inhibitor of Lactation), also decreased milk secretion temporarily when introduced into a mammary gland of lactating goats. FIL was synthesized by primary cultures of goat mammary epithelial cells, and was

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Abelew, Thomas A., Melissa D. Miller, Timothy C. Cope, and T. Richard Nichols. "Local Loss of Proprioception Results in Disruption of Interjoint Coordination During Locomotion in the Cat." Journal of Neurophysiology 84, no. 5 (2000): 2709–14. http://dx.doi.org/10.1152/jn.2000.84.5.2709.

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To investigate the role of localized, proprioceptive feedback in the regulation of interjoint coordination during locomotion, we substantially attenuated neural feedback from the triceps surae muscles in one hindlimb in each of four cats using the method of self-reinnervation. After allowing the recovery of motor innervation, the animals were filmed during level and ramp walking. Deficits were small or undetectable during walking on the level surface or up the ramp, behaviors that require a large range of forces in the triceps surae muscles. During walking down the ramp, when the triceps surae

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Stewart, G. M., C. V. P. Addey, C. H. Knight, and C. J. Wilde. "AUTOCRINE REGULATION OF CASEIN TURNOVER IN GOAT MAMMARY EXPLANTS." Journal of Endocrinology 118, no. 1 (1988): R1—R3. http://dx.doi.org/10.1677/joe.0.118r001.

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ABSTRACT Local feedback control of milk protein secretion was investigated in goat mammary explants by measuring degradation of newly synthesized casein in the presence of a goat milk whey fraction. Reduced net synthesis of [3H]casein in the presence of the milk fraction was due, at least in part, to its degradation during secretion, suggesting that this process is under autocrine regulation.

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10

Emek, Sevcan, Vedat Evren, and Şebnem Bora. "Simulation of glucose regulating mechanism with an agent-based software engineering tool." An International Journal of Optimization and Control: Theories & Applications (IJOCTA) 9, no. 3 (2019): 15–20. http://dx.doi.org/10.11121/ijocta.01.2019.00685.

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This study provides a detailed explanation of a regulating mechanism of the blood glucose levels by an agent-based software engineering tool. Repast Simphony which is used in implementation of this study is an agent-based software engineering tool based on the object-oriented programming using Java language. Agent-based modeling and simulation is a computational methodology for simulating and exploring phenomena that includes a large set of active components represented by agents. The agents are main components situated in space and time of agent-based simulation environment. In this study, we

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11

Schubert, M. L., N. F. Edwards, and G. M. Makhlouf. "Regulation of gastric somatostatin secretion in the mouse by luminal acidity: A local feedback mechanism." Gastroenterology 94, no. 2 (1988): 317–22. http://dx.doi.org/10.1016/0016-5085(88)90418-0.

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12

Mullur, Rashmi, Yan-Yun Liu, and Gregory A. Brent. "Thyroid Hormone Regulation of Metabolism." Physiological Reviews 94, no. 2 (2014): 355–82. http://dx.doi.org/10.1152/physrev.00030.2013.

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Thyroid hormone (TH) is required for normal development as well as regulating metabolism in the adult. The thyroid hormone receptor (TR) isoforms, α and β, are differentially expressed in tissues and have distinct roles in TH signaling. Local activation of thyroxine (T4), to the active form, triiodothyronine (T3), by 5′-deiodinase type 2 (D2) is a key mechanism of TH regulation of metabolism. D2 is expressed in the hypothalamus, white fat, brown adipose tissue (BAT), and skeletal muscle and is required for adaptive thermogenesis. The thyroid gland is regulated by thyrotropin releasing hormone

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13

Yu, Lu, and Jinzhi Wang. "Cooperative Control for Uncertain Multiagent Systems via Distributed Output Regulation." Mathematical Problems in Engineering 2013 (2013): 1–11. http://dx.doi.org/10.1155/2013/898375.

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The distributed robust output regulation problem for multiagent systems is considered. For heterogeneous uncertain linear systems and a linear exosystem, the controlling aim is to stabilize the closed-loop system and meanwhile let the regulated outputs converge to the origin asymptotically, by the help of local interaction. The communication topology considered is directed acyclic graphs, which means directed graphs without loops. With distributed dynamic state feedback controller and output feedback controller, respectively, the solvability of the problem and the algorithm of controller desig

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Glanowska, Katarzyna M., and Suzanne M. Moenter. "Endocannabinoids and prostaglandins both contribute to GnRH neuron-GABAergic afferent local feedback circuits." Journal of Neurophysiology 106, no. 6 (2011): 3073–81. http://dx.doi.org/10.1152/jn.00046.2011.

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Gonadotropin-releasing hormone (GnRH) neurons form the final common pathway for central control of fertility. Regulation of GnRH neurons by long-loop gonadal steroid feedback through steroid receptor-expressing afferents such as GABAergic neurons is well studied. Recently, local central feedback circuits regulating GnRH neurons were identified. GnRH neuronal depolarization induces short-term inhibition of their GABAergic afferents via a mechanism dependent on metabotropic glutamate receptor (mGluR) activation. GnRH neurons are enveloped in astrocytes, which express mGluRs. GnRH neurons also pr

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Burt, Julia, Christian O. Alberto, Matthew P. Parsons, and Michiru Hirasawa. "Local network regulation of orexin neurons in the lateral hypothalamus." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 301, no. 3 (2011): R572—R580. http://dx.doi.org/10.1152/ajpregu.00674.2010.

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Obesity and inadequate sleep are among the most common causes of health problems in modern society. Thus, the discovery that orexin (hypocretin) neurons play a pivotal role in sleep/wake regulation, energy balance, and consummatory behaviors has sparked immense interest in understanding the regulatory mechanisms of these neurons. The local network consisting of neurons and astrocytes within the lateral hypothalamus and perifornical area (LH/PFA), where orexin neurons reside, shapes the output of orexin neurons and the LH/PFA. Orexin neurons not only send projections to remote brain areas but a

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Hearn, Timothy J., and Alex A. R. Webb. "Recent advances in understanding regulation of the Arabidopsis circadian clock by local cellular environment." F1000Research 9 (January 27, 2020): 51. http://dx.doi.org/10.12688/f1000research.21307.1.

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Circadian clocks have evolved to synchronise an organism’s physiology with the environmental rhythms driven by the Earth’s rotation on its axis. Over the past two decades, many of the genetic components of the Arabidopsis thaliana circadian oscillator have been identified. The interactions between these components have been formulized into mathematical models that describe the transcriptional translational feedback loops of the oscillator. More recently, focus has turned to the regulation and functions of the circadian clock. These studies have shown that the system dynamically responds to env

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Serrano, M. Ángeles, Manuel Jurado, and Ramon Reigada. "Negative feedback self-regulation contributes to robust and high-fidelity transmembrane signal transduction." Journal of The Royal Society Interface 10, no. 88 (2013): 20130581. http://dx.doi.org/10.1098/rsif.2013.0581.

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We present a minimal motif model for transmembrane cell signalling. The model assumes signalling events taking place in spatially distributed nanoclusters regulated by a birth/death dynamics. The combination of these spatio-temporal aspects can be modulated to provide a robust and high-fidelity response behaviour without invoking sophisticated modelling of the signalling process as a sequence of cascade reactions and fine-tuned parameters. Our results show that the fact that the distributed signalling events take place in nanoclusters with a finite lifetime regulated by local production is suf

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18

Dekel, Avishai, Kartick C. Sarkar, Fangzhou Jiang, et al. "The global star formation law by supernova feedback." Monthly Notices of the Royal Astronomical Society 488, no. 4 (2019): 4753–78. http://dx.doi.org/10.1093/mnras/stz1919.

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ABSTRACT We address a simple model where the Kennicutt–Schmidt (KS) relation between the macroscopic densities of star formation rate (SFR, ρsfr) and gas (n) in galactic discs emerges from self-regulation of the SFR via supernova feedback. It arises from the physics of supernova bubbles, insensitive to the microscopic SFR recipe and not explicitly dependent on gravity. The key is that the filling factor of SFR-suppressed supernova bubbles self-regulates to a constant, f ∼ 0.5. Expressing the bubble fading radius and time in terms of n, the filling factor is $f\propto S\, n^{-s}$ with s ≃ 1.5,

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Alisafaei, Farid, Doorgesh Sharma Jokhun, G. V. Shivashankar, and Vivek B. Shenoy. "Regulation of nuclear architecture, mechanics, and nucleocytoplasmic shuttling of epigenetic factors by cell geometric constraints." Proceedings of the National Academy of Sciences 116, no. 27 (2019): 13200–13209. http://dx.doi.org/10.1073/pnas.1902035116.

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Cells sense mechanical signals from their microenvironment and transduce them to the nucleus to regulate gene expression programs. To elucidate the physical mechanisms involved in this regulation, we developed an active 3D chemomechanical model to describe the three-way feedback between the adhesions, the cytoskeleton, and the nucleus. The model shows local tensile stresses generated at the interface of the cell and the extracellular matrix regulate the properties of the nucleus, including nuclear morphology, levels of lamin A,C, and histone deacetylation, as these tensile stresses 1) are tran

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Fliers, Eric, Andries Kalsbeek, and Anita Boelen. "MECHANISMS IN ENDOCRINOLOGY: Beyond the fixed setpoint of the hypothalamus–pituitary–thyroid axis." European Journal of Endocrinology 171, no. 5 (2014): R197—R208. http://dx.doi.org/10.1530/eje-14-0285.

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The hypothalamus–pituitary–thyroid (HPT) axis represents a classical example of an endocrine feedback loop. This review discusses dynamic changes in HPT axis setpoint regulation, identifying their molecular and cellular determinants, and speculates about their functional role. Hypothalamic thyrotropin-releasing hormone neurons were identified as key components of thyroid hormone (TH) setpoint regulation already in the 1980s, and this was followed by the demonstration of a pivotal role for the thyroid hormone receptor beta in negative feedback of TH on the hypothalamic and pituitary level. Grad

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21

Schnermann, Jurgen. "Juxtaglomerular cell complex in the regulation of renal salt excretion." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 274, no. 2 (1998): R263—R279. http://dx.doi.org/10.1152/ajpregu.1998.274.2.r263.

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Luminal NaCl concentration at the macula densa (MD) has the two established effects of regulating glomerular arteriolar resistance and renin secretion. Tubuloglomerular feedback (TGF), the inverse relationship between MD NaCl concentration and glomerular filtration rate (GFR), stabilizes distal salt delivery and thereby NaCl excretion in response to random perturbations unrelated to changes in body salt balance. Control of vasomotor tone by TGF is exerted primarily by NaCl transport-dependent changes in local adenosine concentrations. During long-lasting perturbations of MD NaCl concentration,

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22

Mika, D., W. Richter, R. E. Westenbroek, W. A. Catterall, and M. Conti. "PDE4B mediates local feedback regulation of 1-adrenergic cAMP signaling in a sarcolemmal compartment of cardiac myocytes." Journal of Cell Science 127, no. 5 (2014): 1033–42. http://dx.doi.org/10.1242/jcs.140251.

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23

Einer-Jensen, N., and RHF Hunter. "Counter-current transfer in reproductive biology." Reproduction 129, no. 1 (2005): 9–18. http://dx.doi.org/10.1530/rep.1.00278.

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Heat and substances, including gases, steroids and peptide hormones, can pass from venous blood, interstitial fluid and lymph to the arterial blood; the process is called local counter-current transfer. It has been found in various reproductive organs in many animal species and in man: from the testis to the testis and epididymis; from the ovary to the ovary, tube and tubal corner of the uterus; from the tube and uterus to the ovary; from vagina to uterus; and even between brain blood vessels. Local transfer within the ovary has also been found. Local cooling that creates temperature gradients

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Saravanan, Surat, C. Meghana, and Maithreyi Narasimha. "Local, cell-nonautonomous feedback regulation of myosin dynamics patterns transitions in cell behavior: a role for tension and geometry?" Molecular Biology of the Cell 24, no. 15 (2013): 2350–61. http://dx.doi.org/10.1091/mbc.e12-12-0868.

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How robust patterns of tissue dynamics emerge from heterogeneities, stochasticities, and asynchronies in cell behavior is an outstanding question in morphogenesis. A clear understanding of this requires examining the influence of the behavior of single cells on tissue patterning. Here we develop single-cell manipulation strategies to uncover the origin of patterned cell behavior in the amnioserosa during Drosophila dorsal closure. We show that the formation and dissolution of contractile, medial actomyosin networks previously shown to underlie pulsed apical constrictions in the amnioserosa are

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Boyer, Laurent, Christophe Lançon, Karine Baumstarck, Nathalie Parola, Julie Berbis, and Pascal Auquier. "Evaluating the impact of a quality of life assessment with feedback to clinicians in patients with schizophrenia: randomised controlled trial." British Journal of Psychiatry 202, no. 6 (2013): 447–53. http://dx.doi.org/10.1192/bjp.bp.112.123463.

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BackgroundQuality of life (QoL) measurements are increasingly considered to be an important evaluation of the treatment and care provided to patients with schizophrenia. However, there is little evidence that assessing QoL improves patient outcomes in clinical practice.AimsTo investigate the impact of a QoL assessment with feedback for clinicians regarding satisfaction and other health outcomes in patients with schizophrenia.MethodWe conducted a 6-month, prospective, randomised and controlled open-label study. Patients withschizophrenia were assigned to one of three groups: standard psychiatri

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McClamroch, H., and D. Wang. "Linear Feedback Control of Position and Contact Force for a Nonlinear Constrained Mechanism." Journal of Dynamic Systems, Measurement, and Control 112, no. 4 (1990): 640–45. http://dx.doi.org/10.1115/1.2896189.

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A feedback control problem for a constrained mechanism is formulated and solved. The mechanism is controlled by forces applied to the mechanism which are to be adjusted according to a linear control law, based on feedback of the positions and velocities of the mechanism and feedback of the constraint force on the mechanism. The control objective is to achieve accurate and robust local regulation of the motion of the mechanism and of the constraint force on the mechanism. Derivation of a suitable control law is significantly complicated by the nonclassical nature of the differential-algebraic m

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Wood, Paul L. "Pharmacological evaluation of GABAergic and glutamatergic inputs to the nucleus basalis–cortical and the septal–hippocampal cholinergic projections." Canadian Journal of Physiology and Pharmacology 64, no. 3 (1986): 325–28. http://dx.doi.org/10.1139/y86-053.

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The presence of different receptor populations within a given brain area can be effectively evaluated via the local injections of defined receptor agonists and antagonists. Using this approach, it has become evident that the nucleus basalis – cortical cholinergic pathway possesses an inhibitory GABAergic input to the nucleus basalis from the nucleus accumbens as well as a positive glutamatergic feedback from the cortex. The septal–hippocampal cholinergic pathway also possesses an inhibitory GABAergic regulation which consists of a large GABAergic interneuron population in the septum. A glutama

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Jonsson, Amanda, Sahika Inal, Ilke Uguz, et al. "Bioelectronic neural pixel: Chemical stimulation and electrical sensing at the same site." Proceedings of the National Academy of Sciences 113, no. 34 (2016): 9440–45. http://dx.doi.org/10.1073/pnas.1604231113.

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Local control of neuronal activity is central to many therapeutic strategies aiming to treat neurological disorders. Arguably, the best solution would make use of endogenous highly localized and specialized regulatory mechanisms of neuronal activity, and an ideal therapeutic technology should sense activity and deliver endogenous molecules at the same site for the most efficient feedback regulation. Here, we address this challenge with an organic electronic multifunctional device that is capable of chemical stimulation and electrical sensing at the same site, at the single-cell scale. Conducti

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Syarifudin, Amin, and Rakhmat Bowo Suharto. "Analysis Juridical Public Participation Formation of Regional Regulation No. 3 of 2017 on The Implementation of The Business Entertainment In Wonosobo Regency." Jurnal Daulat Hukum 2, no. 1 (2019): 147. http://dx.doi.org/10.30659/jdh.v2i1.4268.

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To set the order and comfort in the Wonosobo regency and Goverment Wonosobo regency make Region Regulation No. 3 of 2017 on the Implementation of Enterprise Entertainment in Wonosobo. This is associated with the rise of karaoke business premises in Wonosobo. But after the regulation passes reap a lot of conflict in the community. This makes the writer interested in making. Juridical Analysis of Public Participation in Formation of Regional Regulation Number. 3 of 2017 on the Implementation of Enterprise Entertainment in Wonosobo,Method of approach used in this study is a sociological juridical

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Hughson, Richard L. "Regulation of Blood Flow at the Onset of Exercise by Feed Forward and Feedback Mechanisms." Canadian Journal of Applied Physiology 28, no. 5 (2003): 774–87. http://dx.doi.org/10.1139/h03-058.

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Blood flow adapts quickly after the onset of exercise to meet the metabolic demands of skeletal muscle. This review approaches the issue of how rapidly blood flow adapts and what the mechanisms for adaptation are primarily from a control theory perspective. Several recent papers have suggested that O2 transport proceeds at a rate that anticipates the metabolic demand over a very wide range of work rates. When considered from a control theory perspective, this implies involvement of feed forward control. Although there is one very important feed forward mechanism in the muscle pump that is acti

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BEN-JACOB, ESHEL, OFER SHOCHET, ADAM TENENBAUM, INON COHEN, ANDRAS CZIRÓK, and TAMÁS VICSEK. "COMMUNICATION, REGULATION AND CONTROL DURING COMPLEX PATTERNING OF BACTERIAL COLONIES." Fractals 02, no. 01 (1994): 15–44. http://dx.doi.org/10.1142/s0218348x9400003x.

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We present a study of interfacial pattern formation during growth of bacterial colonies. Growth of bacterial colony bears similarities to but presents an inherent additional level of complexity compared to non-living systems. In the former case, the building blocks themselves are living systems each with its own autonomous self-interest and internal degrees of freedom. At the same time, efficient adaptation of the colony to adverse growth conditions requires self-organization on all levels — which can be achieved only via cooperative behavior of the bacteria. To do so, the bacteria have develo

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Zhao, Guiling, Humberto C. Joca, Mark T. Nelson, and W. Jonathan Lederer. "ATP- and voltage-dependent electro-metabolic signaling regulates blood flow in heart." Proceedings of the National Academy of Sciences 117, no. 13 (2020): 7461–70. http://dx.doi.org/10.1073/pnas.1922095117.

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Local control of blood flow in the heart is important yet poorly understood. Here we show that ATP-sensitive K+ channels (KATP), hugely abundant in cardiac ventricular myocytes, sense the local myocyte metabolic state and communicate a negative feedback signal-correction upstream electrically. This electro-metabolic voltage signal is transmitted instantaneously to cellular elements in the neighboring microvascular network through gap junctions, where it regulates contractile pericytes and smooth muscle cells and thus blood flow. As myocyte ATP is consumed in excess of production, [ATP]i decrea

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Zhou, Hong, Xinyan Wang, Wendy K. W. Ko, and Anderson O. L. Wong. "Evidence for a Novel Intrapituitary Autocrine/Paracrine Feedback Loop Regulating Growth Hormone Synthesis and Secretion in Grass Carp Pituitary Cells by Functional Interactions between Gonadotrophs and Somatotrophs." Endocrinology 145, no. 12 (2004): 5548–59. http://dx.doi.org/10.1210/en.2004-0362.

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Abstract Gonadotropin (GTH) and GH released from the pituitary are known to interact at multiple levels to modulate the functions of the gonadotrophic and somatotrophic axes. However, their interactions at the pituitary level have not been fully characterized. In this study, autocrine/paracrine regulation of GH synthesis and secretion by local interactions between gonadotrophs and somatotrophs was examined using grass carp pituitary cells as a cell model. Exogenous GTH and GH induced GH release and GH mRNA expression in carp pituitary cells. Removal of endogenous GTH and GH by immunoneutraliza

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Korayem, M. H., H. Tourajizadeh, A. Zehfroosh, and A. H. Korayem. "Optimal regulation of a cable robot in presence of obstacle using optimal adaptive feedback linearization approach." Robotica 33, no. 4 (2014): 933–52. http://dx.doi.org/10.1017/s0263574714000691.

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SUMMARYOptimal path planning of a closed loop cable robot, between two predefined points in presence of obstacles is the goal of this paper. This target is met by proposing a new method of optimal regulation for non linear systems while Dynamic Load Carrying Capacity (DLCC) of the robot is supposed as the related cost function. Feedback linearization is used to linearize the system while Linear Quadratic Regulator (LQR) is employed to optimize the DLCC of the system based on torque and error constraints. Obstacle avoidance for both the end-effector and cables is also considered by the aid of d

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Ludwig, M. "Functional role of intrahypothalamic release of oxytocin and vasopressin: consequences and controversies." American Journal of Physiology-Endocrinology and Metabolism 268, no. 4 (1995): E537—E545. http://dx.doi.org/10.1152/ajpendo.1995.268.4.e537.

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This brief review of vasopressin (VP) and oxytocin (OT) release into the extracellular space of the supraoptic (SON) and paraventricular (PVN) nuclei focuses on recent data illustrating the significance of their intranuclear release and the potential functional consequences. With the use of in vitro techniques, it has been demonstrated that administration of exogenous OT causes local peptide release and that, in vivo, this facilitates the milk ejection reflex. These findings lead to the idea that endogenous peptides are released into the hypothalamic nuclei. Microperfusion techniques have been

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Zheng, Yunhua, Jin Bai, Mulan He, and Anderson O. L. Wong. "Functional Interaction of Spexin and Adiponectin Forming a Local Feedbackin Goldfish Hepatocytes for Feeding Regulation." Journal of the Endocrine Society 5, Supplement_1 (2021): A47. http://dx.doi.org/10.1210/jendso/bvab048.093.

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Abstract Spexin (SPX), a neuropeptide with pleiotropic functions, has been confirmed to be a novel satiety factor in fish models. Adiponectin (AdipoQ), the most abundant adipokine in circulation, is involved in lipid and glucose metabolism and its insulin-sensitizing, cardioprotective, and anti-inflammatory actions are also well-documented. However, the interaction between SPX and AdipoQ has not be reported and very little is known regarding the functions of AdipoQ in non-mammalian species. In this study, AdipoQ was cloned in goldfish and found to be widely expressed at tissue level including

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Fan, Ying, Gonzalo Miguez-Macho, Esteban G. Jobbágy, Robert B. Jackson, and Carlos Otero-Casal. "Hydrologic regulation of plant rooting depth." Proceedings of the National Academy of Sciences 114, no. 40 (2017): 10572–77. http://dx.doi.org/10.1073/pnas.1712381114.

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Plant rooting depth affects ecosystem resilience to environmental stress such as drought. Deep roots connect deep soil/groundwater to the atmosphere, thus influencing the hydrologic cycle and climate. Deep roots enhance bedrock weathering, thus regulating the long-term carbon cycle. However, we know little about how deep roots go and why. Here, we present a global synthesis of 2,200 root observations of >1,000 species along biotic (life form, genus) and abiotic (precipitation, soil, drainage) gradients. Results reveal strong sensitivities of rooting depth to local soil water profiles determ

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Lucy, Matthew C. "Growth hormone regulation of follicular growth." Reproduction, Fertility and Development 24, no. 1 (2012): 19. http://dx.doi.org/10.1071/rd11903.

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The somatotropic axis – consisting of growth hormone (GH), the insulin-like growth factors 1 and 2 (IGF1 and IGF2), GH binding protein (GHBP), IGF binding proteins (IGFBPs) 1 to 6, and the cell-surface receptors for GH and the IGFs – has major effects on growth, lactation and reproduction. The primary target tissues for GH are involved in growth and metabolism. The functionality of the somatotropic axis depends in part on the expression of liver GH receptor (GHR), which determines the amount of IGF1 released from the liver in response to GH. The IGF1 acts as a pleiotropic growth factor and als

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Jaggar, Jonathan H., Valerie A. Porter, W. Jonathan Lederer, and Mark T. Nelson. "Calcium sparks in smooth muscle." American Journal of Physiology-Cell Physiology 278, no. 2 (2000): C235—C256. http://dx.doi.org/10.1152/ajpcell.2000.278.2.c235.

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Local intracellular Ca2+transients, termed Ca2+ sparks, are caused by the coordinated opening of a cluster of ryanodine-sensitive Ca2+ release channels in the sarcoplasmic reticulum of smooth muscle cells. Ca2+ sparks are activated by Ca2+ entry through dihydropyridine-sensitive voltage-dependent Ca2+ channels, although the precise mechanisms of communication of Ca2+ entry to Ca2+ spark activation are not clear in smooth muscle. Ca2+ sparks act as a positive-feedback element to increase smooth muscle contractility, directly by contributing to the global cytoplasmic Ca2+ concentration ([Ca2+])

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Feng, Xiaoping, Di Lu, and Siyu Feng. "Practical Dilemma and Path Innovation of Social Governance: A Case Study of Land Expropriation in China." E3S Web of Conferences 235 (2021): 02072. http://dx.doi.org/10.1051/e3sconf/202123502072.

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In the “Internet+” era, conflicts of land requisition frequently occur. Existing research emphasizes the lack of systems but rarely considers the problems in the implementation of the system. Based on “Internet+”, this article adopts a case analysis method to discuss the governance of land requisition conflicts. This study analyzes the contradictions in the implementation of land acquisition, benefit distribution, procedures and information feedback. The dilemma of social governance stems from the “autonomous space”, “three-dimensional competition” and “independent space” of local governments.

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Cheng, Gheorghe F. Y., Chi-Wai Yuen, and Wei Ge. "Evidence for the existence of a local activin–follistatin negative feedback loop in the goldfish pituitary and its regulation by activin and gonadal steroids." Journal of Endocrinology 195, no. 3 (2007): 373–84. http://dx.doi.org/10.1677/joe-07-0265.

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Activin is an important regulator of gonadotropin expression and production in the vertebrate pituitary, and its activity is fine-tuned by its binding protein follistatin. In the present study, a full-length cDNA for follistatin was cloned in the goldfish, which shows 74% amino acid sequence identity with that of mammals. Recombinant goldfish follistatin expressed in the Chinese hamster ovary cells significantly blocked activin-induced F5-5 cell differentiation. Goldfish follistatin is expressed in a wide range of tissues including the brain, pituitary, ovary, and testis. The expression of fol

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Nafz, B., P. B. Persson, H. Ehmke, and H. R. Kirchheim. "A servo-control system for open- and closed-loop blood pressure regulation." American Journal of Physiology-Renal Physiology 262, no. 2 (1992): F320—F325. http://dx.doi.org/10.1152/ajprenal.1992.262.2.f320.

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An electropneumatic servo-control system is described that can reduce and control arterial blood pressure in experimental animals. The device has been proved useful in the analysis of pressure-dependent physiological processes and allows the following two modes of operation: 1) a conventional open-loop setting that will reduce arterial pressure to a preselected set point and 2) a closed-loop mode that enables an adjustment to a dynamic pressure set point (i.e., the controlled pressure is reduced to a constant value below a reference pressure). A pneumatic servo-control mechanism was chosen to

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Sane, Sanjay P., Robert B. Srygley, and Robert Dudley. "Antennal regulation of migratory flight in the neotropical moth Urania fulgens." Biology Letters 6, no. 3 (2010): 406–9. http://dx.doi.org/10.1098/rsbl.2009.1073.

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Migrating insects use their sensory systems to acquire local and global cues about their surroundings. Previous research on tethered insects suggests that, in addition to vision and cephalic bristles, insects use antennal mechanosensory feedback to maintain their airspeeds. Owing to the large displacements of migratory insects and difficulties inherent in tracking single individuals, the roles of these sensory inputs have never been tested in freely migrating insects. We tracked individual uraniid moths ( Urania fulgens ) as they migrated diurnally over the Panama Canal, and measured airspeeds

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Wilde, C. J., C. V. P. Addey, F. M. Campbell, S. A. Connor, M. A. Kerr, and C. H. Knight. "Autocrine control of milk secretion by a milk protein." Proceedings of the British Society of Animal Production (1972) 1993 (March 1993): 159. http://dx.doi.org/10.1017/s0308229600024831.

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The rate of milk secretion is controlled acutely by the frequency and completeness of milk removal from the mammary gland. Numerous experiments in dairy animals have shown that this acute control is exerted locally within each gland, rather than by circulating galactopoietic hormones (Wilde & Peaker, 1990). Local regulation of milk secretion by milk removal is not related to physical distension of the gland by accumulated milk (Henderson & Peaker, 1984), but is instead the result of changes in the degree of chemical feedback inhibition exerted by a secreted milk constituent.Proteins th

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Doulgeri, Zoe, and Yiannis Karayiannidis. "Force/position control self-tuned to unknown surface slopes using motion variables." Robotica 26, no. 6 (2008): 703–10. http://dx.doi.org/10.1017/s026357470800430x.

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SUMMARYThis work considers the problem of force/position regulation for a robotic finger in compliant contact with an unknown curved surface resulting in uncertain force and position control subspaces. The proposed controller is an adaptive control scheme of a simple structure that achieves the desired target by the on-line tuning of the position and force control actions to their corresponding actual subspaces at the desired point using motion state feedback. The local asymptotic stability of the system equilibrium point is proved and an estimate of the region of attraction is given. The cont

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Callewaert, G., R. G. Johnson, and M. Morad. "Regulation of the secretory response in bovine chromaffin cells." American Journal of Physiology-Cell Physiology 260, no. 4 (1991): C851—C860. http://dx.doi.org/10.1152/ajpcell.1991.260.4.c851.

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The nicotine-induced current and the Ca2+ current were studied in cultured bovine chromaffin cells using the whole cell patch-clamp technique. The dose-response curve for the nicotinic current gave a dissociation constant of 53 microM and a Hill coefficient of 1.3. Desensitization of the nicotinic current was rapid, with time constants of 22 and 155 ms at 10 microM nicotine. At higher concentrations of nicotine, both time constants decreased somewhat, but the most prominent effect was on the ratio of the two components. Recovery from desensitization was fitted by a single exponential with a ti

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Tepper, Sandra, Oliver Mortusewicz, Ewelina Członka, et al. "Restriction of AID activity and somatic hypermutation by PARP-1." Nucleic Acids Research 47, no. 14 (2019): 7418–29. http://dx.doi.org/10.1093/nar/gkz466.

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Abstract Affinity maturation of the humoral immune response depends on somatic hypermutation (SHM) of immunoglobulin (Ig) genes, which is initiated by targeted lesion introduction by activation-induced deaminase (AID), followed by error-prone DNA repair. Stringent regulation of this process is essential to prevent genetic instability, but no negative feedback control has been identified to date. Here we show that poly(ADP-ribose) polymerase-1 (PARP-1) is a key factor restricting AID activity during somatic hypermutation. Poly(ADP-ribose) (PAR) chains formed at DNA breaks trigger AID-PAR associ

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Xing, Jichun, Huajun Li, and Dechun Liu. "Anisotropic Vibration Tactile Model and Human Factor Analysis for a Piezoelectric Tactile Feedback Device." Micromachines 10, no. 7 (2019): 448. http://dx.doi.org/10.3390/mi10070448.

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Tactile feedback technology has important development prospects in interactive technology. In order to enrich the tactile sense of haptic devices under simple control, a piezoelectric haptic feedback device is proposed. The piezoelectric tactile feedback device can realize tactile changes in different excitation voltage amplitudes, different excitation frequencies, and different directions through the ciliary body structure. The principle of the anisotropic vibration of the ciliary body structure was analyzed here, and a tactile model was established. The equivalent friction coefficient under

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Han, Renke, Qiuye Sun, Dazhong Ma, and Bonan Huang. "Modeling Single-Phase Inverter and Its Decentralized Coordinated Control by Using Feedback Linearization." Mathematical Problems in Engineering 2014 (2014): 1–11. http://dx.doi.org/10.1155/2014/581323.

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It is a very crucial problem to make a microgrid operated reasonably and stably. Considering the nonlinear mathematics model of inverter established in this paper, the input-output feedback linearization method is used to transform the nonlinear mathematics model of inverters to a linear tracking synchronization and consensus regulation control problem. Based on the linear mathematics model and multiagent consensus algorithm, a decentralized coordinated controller is proposed to make amplitudes and angles of voltages from inverters be consensus and active and reactive power shared in the desir

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Malpel, S., C. Mendelsohn, and W. V. Cardoso. "Regulation of retinoic acid signaling during lung morphogenesis." Development 127, no. 14 (2000): 3057–67. http://dx.doi.org/10.1242/dev.127.14.3057.

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Little is known about how retinoic acid (RA) synthesis, utilization and metabolism are regulated in the embryonic lung and how these activities relate to lung pattern formation. Here we report that early lung bud formation and subsequent branching morphogenesis are characterized by distinct stages of RA signaling. At the onset of lung development RA signaling is ubiquitously activated in primary buds, as shown by expression of the major RA-synthesizing enzyme, RALDH-2 and activation of a RARE-lacZ transgene. Nevertheless, further airway branching appears to require downregulation of RA pathway

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