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Journal articles on the topic 'Local steroid'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

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1

Zhou, Yuxiang, and Leilai Xu. "Clinical efficacy of different methods for treatment of granulomatous lobular mastitis: A systematic review and network meta-analysis." PLOS ONE 20, no. 2 (2025): e0318236. https://doi.org/10.1371/journal.pone.0318236.

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Objective This network meta-analysis aims to evaluate the recurrence rates of various treatment options for granulomatous lobular mastitis. Methods We systematically searched and identified eligible studies in PubMed, EMBASE, Cochrane Library, and Web of Science databases until September 30, 2023. Original studies reporting the recurrence rates of various treatments were included. Subsequently, literature screening, data extraction, and network meta-analysis were conducted. This study was registered with PROSPERO (registration number CRD 42023434773). Results Nineteen articles involving 1,095

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Yıldırım, Mehmet Erol, Mehmet Kaynar, Ekrem Ozyuvali, et al. "The effectiveness of local steroid injection after internal urethrotomy to avoid recurrence." Archivio Italiano di Urologia e Andrologia 87, no. 4 (2016): 295. http://dx.doi.org/10.4081/aiua.2015.4.295.

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Objective: Local steroid injection to the stricture region after internal urethrotomy (IU) is a promising technique to avoid the recurrence, although the effectiveness and safety of this technique is still controversial. We aimed to determine the efficacy and safety of local steroids as applied with the IU procedure. Material-Method: A total of 83 patients data with urethral stricture in men were examined retrospectively. Patients classified in two groups who had steroid injection with internal urethrotomy or not. Metil prednisolone 40 mg was injected with transurethral injection needle in the

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Manchikanti, Laxmaiah. "Steroid Distancing in Interventional Pain Management During COVID-19 and Beyond: Safe, Effective and Practical Approach." Pain Physician 4S;23, no. 8;4S (2020): S319—S350. http://dx.doi.org/10.36076/ppj.2020/23/s319.

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Background: Since the late 1940s, corticosteroids have been a mainstay class of agents in multiple interventional techniques and intra-articular injections. Exogenous glucocorticoids are structurally and pharmacologically similar to the endogenous hormones. As such, multiple actions of corticosteroids are exhibited, including those of anti-inflammatory and immunosuppressive effects. Epidural injections, with or without steroids, have been extensively used throughout the world. There are reports of epidural injections starting in 1901, with steroids being added to the local anesthetic since 195

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Sandor, Luca F., Reka Ragacs, and David S. Gyori. "Local Effects of Steroid Hormones within the Bone Microenvironment." International Journal of Molecular Sciences 24, no. 24 (2023): 17482. http://dx.doi.org/10.3390/ijms242417482.

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Steroid hormone production via the adrenal cortex, gonads, and placenta (so-called glandular steroidogenesis) is responsible for the endocrine control of the body’s homeostasis and is organized by a feedback regulatory mechanism based on the hypothalamus–pituitary–steroidogenic gland axis. On the other hand, recently discovered extraglandular steroidogenesis occurring locally in different tissues is instead linked to paracrine or autocrine signaling, and it is independent of the control by the hypothalamus and pituitary glands. Bone cells, such as bone-forming osteoblasts, osteoblast-derived o

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Nelis, Hilde, Julie Vanden Bussche, Bartosz Wojciechowicz, et al. "Steroids in the equine oviduct: synthesis, local concentrations and receptor expression." Reproduction, Fertility and Development 28, no. 9 (2016): 1390. http://dx.doi.org/10.1071/rd14483.

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Steroids play an important role in mammalian reproduction and early pregnancy. Although systemic changes in steroid concentrations have been well documented, it is not clear how these correlate with local steroid concentrations in the genital tract. We hypothesised that, in the horse, the preimplantation embryo may be subjected to high local steroid concentrations for several days. Therefore, we measured progesterone, 17-hydroxyprogesterone, 17β-oestradiol, testosterone and 17α-testosterone concentrations in equine oviductal tissue by ultra-HPLC coupled with tandem mass spectrometry, and proge

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Qiu, Yu, and Ruihua Shi. "Roles of Steroids in Preventing Esophageal Stricture after Endoscopic Resection." Canadian Journal of Gastroenterology and Hepatology 2019 (April 1, 2019): 1–9. http://dx.doi.org/10.1155/2019/5380815.

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Background and Purposes. Endoscopic resection has been worldwide recognized as a treatment strategy for early esophageal lesions. The occurrence of esophageal stricture after endoscopic resection will reduce the quality of life of patients. This study will evaluate the efficacy and safety of steroids in the prevention of esophageal stricture after endoscopic resection and the influence of different steroid administration methods.Methods. In the relevant literature database, literature from 2008 to 2018 is retrieved by using preset keywords, the search results are carefully screened, and the co

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Ahmed, Anis, Md Rafiqul Islam, Hasan Zahidur Rahman, et al. "Efficacy of Local Corticosteroid in Idiopathic Carpal Tunnel Syndrome: A Randomized Controlled Trial." Bangladesh Journal of Neuroscience 28, no. 1 (2013): 10–15. http://dx.doi.org/10.3329/bjn.v28i1.17187.

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Background: Carpal tunnel syndrome (CTS) is a common health problem in Bangladesh especially among women. It causes significant morbidity and reduces work output in affected patients. There are few treatment options available like oral steroid, steroid injection, UST, surgical treatment etc. Considering the cost, time and consequence of surgery, short term nonsurgical management is desirable e.g. local steroid injection in the affected limb. Therefore a comparative analysis is necessary to understand the efficacy of local steroid injection.Objective: To evaluate the efficacy of local corticost

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Bhadu, D., S. Vyas, and U. Kumar. "THU0415 MELTING OF TOPHI WITH LOCAL STEROIDS IN CHRONIC TOPHACEOUS GOUT: AN OBSERVATIONAL STUDY." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 445. http://dx.doi.org/10.1136/annrheumdis-2020-eular.2918.

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Background:Chronic tophaceous gout is usually difficult to treat with urate lowering therapy (ULT) [1]. Faster resolution of tophi has been seen with use of pegloticase [2], but this drug is costly and not widely available. Local steroid use is recommended in acute gouty arthritis but its role in reduction of tophi has not been studied. This study was aimed to see the effect of local steroids in tophi resolution.Objectives:To study the change in size of gouty tophi with local steroid injection compared to conventional treatment.Methods:Four crystal proven chronic tophaceous gout patients with

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Reda, Ramez, Wael Wageh, Mohammed Fawaz, and Wassim Mikhaiel. "Comparison between local steroids and local steroids plus itraconazole effect in prevention of recurrence of allergic fungal sinusitis in hypertensive and/or diabetic patients." Egyptian Journal of Otolaryngology 35, no. 1 (2019): 25–29. http://dx.doi.org/10.4103/ejo.ejo_64_18.

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Abstract Background Allergic fungal rhinosinusitis (AFRS) is the most common type of fungal diseases in nose and paranasal sinuses. It is due to hypersensitivity to fungal antigens. The standard treatment for control of AFRS is endoscopic sinus surgery followed by systemic and/or topical steroids. In spite of steroids known to have promising results for the management of AFRS, their prolonged use is not always advised. So, some authors have tried to decrease the recurrence rate of AFRS by using antifungal treatment. In this study, we compared the efficacy of local steroids (Fluticasone nasal s

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Sreeja, Hareendranathan Radhamani, Roseline John Juliet, Kaithadiyil Abdul Khayar Kutty Kabeer, John Sajith, and Vasudevan Bindhu. "Prospective Study of Outcome of Nocturnal Wrist Splint versus Local Steroid Injection in Mild and Moderate Carpal Tunnel Syndrome." International Journal of Pharmaceutical and Clinical Research 15, no. 6 (2023): 398–404. https://doi.org/10.5281/zenodo.12170895.

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Carpal tunnel syndrome, a common entrapment neuropathy involving median nerve at the wrist is characterized by pain and paresthesia of hands and in severe cases numbness and weakness of thenar muscles. Non-surgical methods have a role in management of mild and moderate cases of CTS. Common options include nocturnal wrist splint and local steroid injection. We could not come across any Indian studies comparing these two methods. This prospective observational study conducted at Government medical college Ernakulam aimed at comparing these two modalities of treatment in mild and moderate cases o

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Saloniemi, Taija, Heli Jokela, Leena Strauss, Pirjo Pakarinen та Matti Poutanen. "The diversity of sex steroid action: novel functions of hydroxysteroid (17β) dehydrogenases as revealed by genetically modified mouse models". Journal of Endocrinology 212, № 1 (2011): 27–40. http://dx.doi.org/10.1530/joe-11-0315.

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Disturbed action of sex steroid hormones, i.e. androgens and estrogens, is involved in the pathogenesis of various severe diseases in humans. Interestingly, recent studies have provided data further supporting the hypothesis that the circulating hormone concentrations do not explain all physiological and pathological processes observed in hormone-dependent tissues, while the intratissue sex steroid concentrations are determined by the expression of steroid metabolising enzymes in the neighbouring cells (paracrine action) and/or by target cells themselves (intracrine action). This local sex ste

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Li, Sean S., Suellen S. Li, and Reid A. Abrams. "Heterotopic ossification after local steroid injection." BMJ Case Reports 13, no. 12 (2020): e235371. http://dx.doi.org/10.1136/bcr-2020-235371.

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Pachydermodactyly (PDD) is a rare, benign disease associated with progressive swelling of the periarticular soft tissue of phalangeal hand joints typically treated with local steroid injections. We present a case of a 37-year-old man with PDD treated with local steroid injections. He later developed heterotopic ossification and para-articular calcifications in the injection sites. Heterotopic ossification is not associated with PDD nor is it a recognised complication of local steroid injections. This is the first case in literature of heterotopic ossification occurring after local steroid inje

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Cleary, John D. "Local Atrophy following Steroid Injection." Annals of Pharmacotherapy 36, no. 4 (2002): 726. http://dx.doi.org/10.1345/aph.1a318.

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Go, K. G., J. G. Ter Haar, L. de Ley, et al. "The Effect of Steroid Treatment on Lipocortin Immunoreactivity of Rat Brain." Mediators of Inflammation 3, no. 3 (1994): 177–80. http://dx.doi.org/10.1155/s0962935194000232.

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Lipocortin-1, lipocortin-2 and lipocortin-5 were immunohistochemically assessed in rats. Apart from animals receiving no treatment, other animals received pretreatment with methylprednisolone, or the 21-aminosteroid U-74389F. Whereas Hpocortin immunoreactivity was absent in the greater part of the brain in animals not pretreated with steroid (except in sporadic microglial cells and choroid plexus), there was obvious immunostaining of parenchymatous elements in steroid pretreated animals. In the steroid pretreated animals lipocortin immunoreactivity of the brain tissue may indicate local format

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Manchikanti, Laxmaiah. "Epidural Injections for Lumbar Radiculopathy and Spinal Stenosis: A Comparative Systematic Review and Meta-Analysis." March 2016 3;19, no. 3;3 (2016): E365—E410. http://dx.doi.org/10.36076/ppj/2016.19.e365.

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Background: The prevalence of chronic low back pain and related disability is rapidly increasing as are the myriad treatments, including epidural injections. Even though epidural injections are one of the most commonly performed procedures in managing low back and lower extremity pain, starting in 1901 with local anesthetic alone, conflicting recommendations have been provided, despite the extensive literature. Recently Chou et al performed a technology assessment review for Agency for Healthcare Research and Quality (AHRQ) part of which was published in Annals of Internal Medicine showing lac

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Adedapo, A. A., J. O. Olopade, A. B. Saba, and O. A. Dina. "Effec of corticosteriod administration on the infectivity of Tyypansome brucei (8/18) in the Nigerian domestic chickens (Gallus Gallus Domesticus)." Nigerian Journal of Animal Production 33, no. 1 (2021): 140–44. http://dx.doi.org/10.51791/njap.v33i1.2224.

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This study was aimed at determining how the infectivity of trypansome brucei could be affected by steriod administration to the local chickens. It has been shown that Nigeria domestic chickens were susceptible to Trypanosome brucei (8/18), In the course of this study the Try some brucei brucei (8/18) was found to have lost Its infectivity to the local chickens. Even steroid administration at both low (0.2mg/ml) and high (1.0inglinl) dosage and prolonged administration of the steroid could not change this occurrence. The study thus concluded that serial passage of T brucei brucei (8/18) over a

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Madiha Malik, Usman Ahmad Kamboh, Muhammad Owais Khan, et al. "Comparison of the Efficacy of Oral and Local Steroids in the Management of Carpal Tunnel Syndrome." Pakistan Journal Of Neurological Surgery 28, no. 3 (2024): 415–21. https://doi.org/10.36552/pjns.v28i3.1005.

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Objective: This research was conducted to compare the efficacy of oral steroids with local steroid injection in the carpal tunnel as regards relieving the symptoms and improvement in neurophysiological parameters. Materials and Methods: This study was performed at the Neurology Department, Punjab Institute of Neurosciences, Lahore. 72 patients were part of the study and divided into 2 groups; Group A (oral steroids) and B (steroid injection). Patients in Group A received a local injection of 1.5cc Normal Saline and oral prednisolone (20 mg once daily for two weeks, followed by 10 mg once daily

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GÜNEŞ, Mustafa, Muzaffer Oğuz KELEŞ, Nesibe Sinem ÇİLOĞLU, Orhan KOCA, and Mehmet AKYÜZ. "Cavernous Hemangioma of the Scrotum Treated with Local Steroid: Case Report." Turkiye Klinikleri Journal of Medical Sciences 33, no. 1 (2013): 241–43. http://dx.doi.org/10.5336/medsci.2011-23747.

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Rathore, Pankaj, Sahil Garg, and Shivam Bhati. "A comparative analysis of functional outcome of local steroid and PRP in plantar fasciitis." Journal of Bone and Joint Diseases 39, no. 1 (2024): 20–25. http://dx.doi.org/10.4103/jbjd.jbjd_46_23.

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Abstract Background: Plantar fasciitis is a common orthopedic issue that affects the quality of life. Various modalities of treatment have been tried for this condition, extending from conservative treatment to surgical treatment. Various studies have been conducted in different parts of the world to compare the results of local platelet-rich plasma (PRP) and steroids with varying results. Materials and Methods: We collected data at Mahatma Gandhi Medical College and Hospital, Jaipur, India with the approval of the IEC (Ethical Committee). From April 2016 to March 2017, 67 patients were includ

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Chakraborty, Soura, Jhuma Pramanik, and Bidesh Mahata. "Revisiting steroidogenesis and its role in immune regulation with the advanced tools and technologies." Genes & Immunity 22, no. 3 (2021): 125–40. http://dx.doi.org/10.1038/s41435-021-00139-3.

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AbstractHistorically tools and technologies facilitated scientific discoveries. Steroid hormone research is not an exception. Unfortunately, the dramatic advancement of the field faded this research area and flagged it as a solved topic. However, it should have been the opposite. The area should glitter with its strong foundation and attract next-generation scientists. Over the past century, a myriad of new facts on biochemistry, molecular biology, cell biology, physiology and pathology of the steroid hormones was discovered. Several innovations were made and translated into life-saving treatm

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Williamson, IJ, SP Matusiewicz, PH Brown, AP Greening, and GK Crompton. "Frequency of voice problems and cough in patients using pressurized aerosol inhaled steroid preparations." European Respiratory Journal 8, no. 4 (1995): 590–92. http://dx.doi.org/10.1183/09031936.95.08040590.

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The aim of the study was to assess the prevalence of throat and voice symptoms in asthma patients using pressurized aerosol, metered-dose, inhaled corticosteroid preparations. A questionnaire was administered to hospital out-patients in an asthma clinic and to a control group attending a diabetic clinic. Two hundred and fifty five consecutive out-patients using pressurized aerosol inhaled corticosteroids and 100 controls were surveyed. One hundred and forty seven (58%) patients taking inhaled steroids reported voice dysphonia or throat symptoms compared with 13% of control patients. Women admi

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Kwak, Sang Gyu, Jae Bum Kwon, Young Woo Seo, and Won-Kee Choi. "Efficacy of periarticular versus intravenous steroid on postoperative pain and nausea in patients undergoing total knee arthroplasty with local infiltration analgesia: A systematic review and network meta-analysis." Medicine 104, no. 29 (2025): e43140. https://doi.org/10.1097/md.0000000000043140.

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Background: To compare the effects of postoperative pain relief, nausea relief, and occurrence of adverse effects associated with steroid use between single-dose intravenous steroid (SDIV) and periarticular injection (PAI) of steroid after total knee arthroplasty. Methods: This systematic review and network meta-analysis was conducted in accordance with PRISMA guidelines. Randomized controlled trials involving patients undergoing primary unilateral total knee arthroplasty with local infiltration analgesia were included. Studies comparing SDIV, PAI, or no steroid use were selected through a com

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Manchikanti, Laxmaiah. "Effectiveness of Therapeutic Lumbar Transforaminal Epidural Steroid Injections in Managing Lumbar Spinal Pain." Pain Physician 3;15, no. 3;5 (2012): E199—E245. http://dx.doi.org/10.36076/ppj.2012/15/e199.

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Background: Among the multiple interventions used in managing chronic spinal pain, lumbar epidural injections have been used extensively to treat lumbar radicular pain. Among caudal, interlaminar, and transforaminal, transforaminal epidural injections have gained rapid and widespread acceptance for the treatment of lumbar and lower extremity pain. The potential advantages of transforaminal over interlaminar and caudal, include targeted delivery of a steroid to the site of pathology, presumably onto an inflamed nerve root. However, there are only a few well-designed, randomized, controlled stud

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Lee, Jung Hwan. "Comparison of Clinical Efficacy of Epidural Injection With or Without Steroid in Lumbosacral Disc Herniation: A Systematic Review and Meta-analysis." January 2018 1, no. 21;1 (2018): 449–67. http://dx.doi.org/10.36076/ppj.2018.5.449.

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Background: Epidural injection is performed for treatment of back and radicular pain in patients with lumbosacral disc herniation (LDH). Steroids are usually administered to effectively remove inflammatory mediators, and local anesthetics or saline also contribute to pain reduction by washing out chemical mediators or blocking the nociceptor activity. Controversy exists regarding whether steroids produce superior clinical effects compared with local anesthetics or saline. Objectives: This study investigated whether epidural injection of steroids produces better clinical effects than local anes

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Ebner, M. J., D. I. Corol, H. Havlíková, J. W. Honour, and J. P. Fry. "Identification of Neuroactive Steroids and Their Precursors and Metabolites in Adult Male Rat Brain." Endocrinology 147, no. 1 (2006): 179–90. http://dx.doi.org/10.1210/en.2005-1065.

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Steroids in the brain arise both from local synthesis and from peripheral sources and have a variety of effects on neuronal function. However, there is little direct chemical evidence for the range of steroids present in brain or of the pathways for their synthesis and inactivation. This information is a prerequisite for understanding the regulation and function of brain steroids. After extraction from adult male rat brain, we have fractionated free steroids and their sulfate esters and then converted them to heptafluorobutyrate or methyloxime-trimethylsilyl ether derivatives for unequivocal i

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Misawa, Norihiko, Mizuki Tagami, Atsushi Sakai, Takeya Kohno та Shigeru Honda. "Rapid Regression of Scleral Melting Associated with Tumor Necrosis Factor-α in a Case of Surgically Induced Necrotizing Scleritis". Case Reports in Ophthalmology 11, № 2 (2020): 418–22. http://dx.doi.org/10.1159/000509260.

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Purpose: To report a case with rapid regression of scleral melting associated with tumor necrosis factor-α (TNF-α) in a surgically induced necrotizing scleritis (SINS) patient treated with local steroid therapy. Case Presentation: An 85-year-old male patient presented with conjunctival tumor in his right eye. Complete resection of the tumor lesion and conjunctival re-construction were performed. Local steroid drops were administered until 1 month after surgery, and a good clinical course was achieved. However, after stopping the local steroid, scleral melting to the uvea occurred on the center

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Ito, Eichi, Hiroaki Shima, Kosho Togei, et al. "Dislocations of the second and third metatarsophalangeal joints after local steroid injection in patients with refractory metatarsalgia: A case report." SAGE Open Medical Case Reports 9 (January 2021): 2050313X2110467. http://dx.doi.org/10.1177/2050313x211046744.

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Local steroid injections are frequently administered to patients with refractory metatarsalgia. No reports have described dislocation of the second and third metatarsophalangeal joints after local steroid injections. A 46-year-old woman had suffered from metatarsalgia and received multiple local steroid injections for over 2 years. The second and third metatarsophalangeal joints revealed dorsal dislocations on the lateral radiograph. Therefore, collateral ligament reconstruction of the metatarsophalangeal joints was performed. Intraoperative findings suggested that the rupture of the plantar p

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Wang, Qing-Xia, Yuan Ding, Qi-Liu Qian, Yin-Nan Zhu, and Rui-Hua Shi. "Predictors of stricture after endoscopic submucosal dissection of the esophagus and steroids application." World Journal of Gastrointestinal Endoscopy 16, no. 9 (2024): 509–18. http://dx.doi.org/10.4253/wjge.v16.i9.509.

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BACKGROUND Endoscopic submucosal dissection (ESD) is a reliable method to resect early esophageal cancer. Esophageal stricture is one of the major complications after ESD of the esophagus. Steroid prophylaxis for esophageal strictures, particularly local injection of triamcinolone acetonide (TA), is a relatively effective method to prevent esophageal strictures. However, even with steroid prophylaxis, stenosis still occurs in up to 45% of patients. Predicting the risk of stenosis formation after local TA injection would enable additional interventions in risky patients. AIM To identify the pre

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Alexeeff, M. "LIGAMENTUM PATELLAE RUPTURE FOLLOWING LOCAL STEROID INJECTION." ANZ Journal of Surgery 56, no. 9 (1986): 681–83. http://dx.doi.org/10.1111/j.1445-2197.1986.tb02372.x.

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Csizy and Hintermann. "Achilles Tendon Rupture After Local Steroid Injection." Swiss Surgery 7, no. 4 (2001): 184–89. http://dx.doi.org/10.1024/1023-9332.7.4.184.

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Obgleich hinlänglich bekannt ist, dass Steroide das Rupturrisiko von Sehnen erhöhen, werden zur Behandlung der Achillodynie lokal infiltrierte Steroide immer noch angewandt. In den drei beschriebenen Fällen zeigt sich ein inadäquater Rupturmechanismus sowie intraoperativ nekrotische Veränderungen der Sehnenstruktur, welche an intakten Sehnen nicht gesehen werden. Alle Patienten werden operativ mit einer Rekonstruktionstechnik versorgt, wobei gesundes, körpereigenes Material zur Überbrückung von bestehenden Gewebedefekten verwendet wird. Obschon in einem Fall eine relevante lokale Heilungsstöru

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Ohta, Yukinori, Norimitsu Saitoh, Hiroyuki Tanuma, Takao Fujimura, and Kensei Katsuoka. "Local Cytokine Expression in Steroid-ModifiedTinea Faciei." Journal of Dermatology 25, no. 6 (1998): 362–66. http://dx.doi.org/10.1111/j.1346-8138.1998.tb02415.x.

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Maillefert, Jean Francis, Serge Aho, Christine Piroth-Chatard, and Christian Tavernier. "Cortisol levels after single local steroid injection." American Journal of Medicine 100, no. 5 (1996): 586–87. http://dx.doi.org/10.1016/s0002-9343(96)80111-2.

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Gella, I. M., A. I. Gladkova, V. A. Zolotukhina, and N. A. Karpenko. "Local antiandrogenic activity of steroid 3-spirooxiranes." Pharmaceutical Chemistry Journal 29, no. 11 (1995): 753–56. http://dx.doi.org/10.1007/bf02331853.

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Reis, ND, S. Karkabi, and C. Zinman. "Metatarsophalangeal joint dislocation after local steroid injection." Journal of Bone and Joint Surgery. British volume 71-B, no. 5 (1989): 864. http://dx.doi.org/10.1302/0301-620x.71b5.2584267.

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Lei, Ting, Yiyi Wang, Mingqing Li, and Long Hua. "Clinical efficacy of multiple intra-articular injection for hip osteoarthritis." Bone & Joint Journal 106-B, no. 6 (2024): 532–39. http://dx.doi.org/10.1302/0301-620x.106b6.bjj-2023-1272.r1.

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AimsIntra-articular (IA) injection may be used when treating hip osteoarthritis (OA). Common injections include steroids, hyaluronic acid (HA), local anaesthetic, and platelet-rich plasma (PRP). Network meta-analysis allows for comparisons between two or more treatment groups and uses direct and indirect comparisons between interventions. This network meta-analysis aims to compare the efficacy of various IA injections used in the management of hip OA with a follow-up of up to six months.MethodsThis systematic review and network meta-analysis used a Bayesian random-effects model to evaluate the

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Heywood, R. L., S. N. Ifeacho, and A. A. Narula. "Effect of intratympanic steroid administration on sensorineural hearing loss associated with acute otitis media." Journal of Laryngology & Otology 130, no. 6 (2016): 532–35. http://dx.doi.org/10.1017/s0022215116001110.

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AbstractObjective:To evaluate a small cohort of patients who presented with symptoms and signs consistent with acute infective sensorineural hearing loss who were treated with intratympanic steroids.Method:Seven patients received a 7-day course of oral antibiotics and oral prednisolone followed by 3 intratympanic injections of methylprednisolone and 1 week of topical dexamethasone drops.Results:Hearing improved in 57 per cent of patients (four out of seven). The mean improvement in this group was 24 dB (range, 10–52 dB). The magnitude of the sensorineural hearing loss at presentation was less

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Gibson, Douglas, Ioannis Simitsidellis, Frances Collins, and Philippa Saunders. "Endometrial Intracrinology: Oestrogens, Androgens and Endometrial Disorders." International Journal of Molecular Sciences 19, no. 10 (2018): 3276. http://dx.doi.org/10.3390/ijms19103276.

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Peripheral tissue metabolism of steroids (intracrinology) is now accepted as a key way in which tissues, such as the endometrium, can utilise inactive steroids present in the blood to respond to local physiological demands and ‘fine-tune’ the activation or inhibition of steroid hormone receptor-dependent processes. Expression of enzymes that play a critical role in the activation and inactivation of bioactive oestrogens (E1, E2) and androgens (A4, T, DHT), as well as expression of steroid hormone receptors, has been detected in endometrial tissues and cells recovered during the menstrual cycle

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Bourne, I. H. J. "Local Corticosteroid Injection Therapy." Acupuncture in Medicine 16, no. 2 (1998): 95–102. http://dx.doi.org/10.1136/aim.16.2.95.

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The advent of injectable insoluble corticosteroids in 1952 allowed steroid injected at tender spots to remain long enough to destroy affected tissue and allow regrowth of normal fibres. Injection of small doses of triamcinolone and lignocaine directly into trigger points has proved a success in relieving chronic pain associated with localised fibromyalgic lesions in 70% of the author's personal series of 840 patients. Each steroid injection given in this series has been recorded with a diagram of its exact position. This has shown that recurrence of pain is very rarely associated with recurren

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Kvasnitskyi, M. V. "EPIDURAL INJECTIONS IN THE TREATMENT OF RADICULAR SYNDROME AND CHRONIC LUMBAR PAIN IN DEGENERATIVE-DYSTROPHIC SPINE DAMAGE." Клінічна та профілактична медицина 1, no. 19 (2022): 78–89. http://dx.doi.org/10.31612/2616-4868.1(19).2022.10.

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Aim. To investigate the methodology and effectiveness of epidural steroid injection for radicular syndrome and lower back pain caused by degenerative-dystrophic process. Research methods: bibliosemantic, comparative, systemic. Results. A literature review and our study proved a high efficacy of both monotherapy and combined epidural steroid injections in treatment of chronic lumbar pain and radicular syndrome caused by degenerative-dystrophic spine damage. Epidural steroid injections are indicated for intervertebral disc herniation, spondyloarthritis, spinal canal stenosis, spondyl

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Hanauer, Stephen B. "Clinical Experience with Tixocortol Pivalate." Canadian Journal of Gastroenterology 2, no. 4 (1988): 156–58. http://dx.doi.org/10.1155/1988/819089.

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Tixocortol pivalate, the 21-thiol derivative of hydrocortisone. is a newly synthesized steroid with topical anti-inflammatory properties but is devoid of systemic glucocorticoid and mineralocorticoid activities and toxicity. The mechanism of action appears to be similar to that of other corticosteroids with regard to steroid binding sites and prostaglandin biosynthesis, however. the disassociation between local and systemic effects is due to a 'first pass' liver metabolism and rapid transformation with in red blood cells. ln both open and controlled studies in patients with acute or recurrent

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Venkat, Arthi Ganesh, Sruthi Arepalli, Sumit Sharma, et al. "Local therapy for cancer therapy-associated uveitis: a case series and review of the literature." British Journal of Ophthalmology 104, no. 5 (2019): 703–11. http://dx.doi.org/10.1136/bjophthalmol-2019-314403.

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Background/aimsImmunotherapy and targeted therapy for metastatic cancer may cause immune-related adverse events (irAEs) such as uveitis. If irAEs are severe or require systemic steroids, cancer therapy is often held or discontinued. Local steroid therapy for cancer therapy-associated uveitis allows the continuation of cancer therapy. This series demonstrates successful management of cancer therapy-associated uveitis with local therapy based on uveitis subtype.MethodsThis is an Institutional Review Board-approved retrospective case series of patients with uveitis secondary to immunotherapy or t

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Mehmood, Tariq, Muhammad Rashid Iqbal, Chaudhry Raheel Ranjha, Mudassar Iqbal, Aijaz Ali, and Ameer Yaseer Zaid. "Efficacy of Transforaminal Epidural Steroid Injection with Local Anesthetic and Ozone Versus Transforaminal Epidural Steroid Injection with Local Anesthetic in Patients with Lumbar Radiculopathy." Pakistan Armed Forces Medical Journal 74, no. 6 (2024): 1609–13. https://doi.org/10.51253/pafmj.v74i6.10624.

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Objective: To compare the efficacy of Transforaminal Epidural Steroid Injection with local anesthetic versus Transforaminal Epidural Steroid Injection with local anesthetic and Ozone in patients with lumbar spine radiculopathy. Study Design: Quasi-experimental study. Place and Duration of Study: Pain Management Centre, Department of Anesthesia, Combined Military Hospital Rawalpindi, Pakistan from Oct 2022- Mar 2023. Methodology: A total of 412 patients who underwent interventional procedures for radiculopathy were included in the study. These patients were divided into two equal groups, group-

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Jarry, H., M. Dietrich, E. Düker, and W. Wuttke. "Effects of systemic and local administration of etomidate on adrenocortical steroidogenesis in male rats." Acta Endocrinologica 114, no. 3 (1987): 402–9. http://dx.doi.org/10.1530/acta.0.1140402.

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Abstract. A method for focal dialysis of the adrenal cortex is introduced allowing determination of adrenal steroid local release rates in conscious, freely moving rats. Etomidate, an anaesthetic drug known to interfere with adrenal steroid synthesis, blocks not only corticosterone but also aldosterone and, to a lesser degree, progesterone release. Intra-adrenal application of the drug via the dialysis system for a defined time resulted in low release rates of corticosterone without inducing sedation of the animals or even anaesthesia. Remaining low steroid concentrations during the next 5 h a

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Labrie, F., V. Luu-The, SX Lin, et al. "Intracrinology: role of the family of 17 beta-hydroxysteroid dehydrogenases in human physiology and disease." Journal of Molecular Endocrinology 25, no. 1 (2000): 1–16. http://dx.doi.org/10.1677/jme.0.0250001.

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In women and men, an important proportion of estrogens and androgens are synthesized locally at their site of action in peripheral target tissues. This new field of endocrinology has been called intracrinology. In postmenopausal women, 100% of active sex steroids are synthesized in peripheral target tissues from inactive steroid precursors while, in adult men, approximately 50% of androgens are made locally in intracrine target tissues. The last and key step in the formation of all estrogens and androgens is catalyzed by members of the family of 17beta-hydroxysteroid dehydrogenases (17 beta-HS

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Rybak, Leonard P., and Randall Falconer. "Pediatric Laryngeal Sarcoidosis." Annals of Otology, Rhinology & Laryngology 96, no. 6 (1987): 670–73. http://dx.doi.org/10.1177/000348948709600611.

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Numerous cases of sarcoidosis, but few cases of well-documented laryngeal involvement, have been reported in the pediatric literature. Isolated laryngeal involvement is a most unusual presentation of sarcoidosis. Such a case is reported here, along with a review of laryngeal sarcoidosis in the pediatric population. Differential diagnosis, diagnostic evaluation, and treatment options are discussed. Intralesional steroid injection provides local therapy with fewer complications than systemic steroids.

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Chilton, S. A. "Tennis Elbow: A Combined Approach Using Acupuncture and Local Corticosteroid Injection." Acupuncture in Medicine 15, no. 2 (1997): 77–78. http://dx.doi.org/10.1136/aim.15.2.77.

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In a controlled study, a group of 16 patients in a north of England general practice received acupuncture treatment for tennis elbow, followed by a small dose of corticosteroid with lignocaine to a residual tender spot at the elbow. These patients were compared with a similar group of 19 who received a larger dose to a tender spot at the lateral epicondyle, without any initial acupuncture treatment. In the acupuncture with steroid group: 13 patients had benefited following two treatment sessions, two after three sessions and one was no better at the end of the permitted three treatments. In th

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Shapira, Michael Y., Allan I. Bloom, Reuven Or, et al. "Intra-Arterial Catheter Directed Immunosuppressive Therapy for Steroid Resistant or Dependent Graft vs. Host Disease (GVHD)." Blood 110, no. 11 (2007): 4960. http://dx.doi.org/10.1182/blood.v110.11.4960.4960.

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Abstract Introduction: Prolonged treatment of graft vs. host disease (GVHD) is extremely immunosuppressive. Local therapy with intra-arterial (IA) injection of steroids may induce remission with lower extent of systemic immune suppression. Here, we present our experience with IA treatment of gastrointestinal (GI) and/or hepatic steroid resistant/dependent GVHD with 2 consecutive protocols. Patients and methods: Thirty five patients (37 GVHD events (hepatic, n=15), (GI, n=16), (combined, n=6)) were treated with 53 IA sessions. Most side effects were minor. Results: We found that IA steroid ther

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Safi, Ali Shahad, Hussein A. Alseady, and Mohammed H. Younise. "Comparison of surgical out come between virgin carpal tunnel syndrome and previous local steroid injected tunnel." Muthanna Medical Journal 7, no. 2 (2020): 33–40. http://dx.doi.org/10.52113/1/7.2/20.33.

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Carpal tunnel syndrome(CTS) is the most commonly occurring peripheral nerve compression neuropathy and its condition characterized by an abnormality of the median nerve function due to compression of the nerve within the carpal tunnel. Surgical release of the transverse carpal ligament is an effective treatment for patients with CTS. Non-steroidal anti-inflammatory drugs, diuretics, vitamin B6 injection, ultrasound therapy, laser therapy, acupuncture, magnetic therapy, bracing and local steroid injections have been used for closed treatment of CTS and effective results in the short-term treatm

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Safi, Ali Shahad. "Comparison of surgical out come between virgin carpal tunnel syndrome and previous local steroid injected tunnel." Muthanna Medical Journal 7, no. 2 (2020): 18–40. http://dx.doi.org/10.52113/1/7.2/2020.40.

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"Carpal tunnel syndrome(CTS) is the most commonly occurring peripheral nerve compression neuropathy and its condition characterized by an abnormality of the median nerve function due to compression of the nerve within the carpal tunnel. Surgical release of the transverse carpal ligament is an effective treatment for patients with CTS. Non-steroidal anti-inflammatory drugs, diuretics, vitamin B6 injection, ultrasound therapy, laser therapy, acupuncture, magnetic therapy, bracing and local steroid injections have been used for closed treatment of CTS and effective results in the short-term treat

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LAMBERT, M. A., R. J. MORTON, and J. P. SLOAN. "Controlled Study of the Use of Local Steroid Injection in the Treatment of Trigger Finger and Thumb." Journal of Hand Surgery 17, no. 1 (1992): 69–70. http://dx.doi.org/10.1016/0266-7681(92)90014-s.

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A controlled double-blind prospective study of injection of methylprednisolone acetate plus local anaesthetic against a control injection of a local anaesthetic in the treatment of trigger finger and thumb has shown a 60% success rate for the steroid injection against 16% for the control group (p < 0.05). This is the first controlled trial of local steroid therapy in this condition.

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