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Journal articles on the topic 'Localized GaN growth'

Author: Grafiati

Published: 11 January 2025

Last updated: 31 July 2025

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1

Chang, Chiao-Yun, Huei-Min Huang, Yu-Pin Lan, et al. "Growth and Characteristics of a-Plane GaN/ZnO/GaN Heterostructure." MRS Proceedings 1538 (2013): 303–7. http://dx.doi.org/10.1557/opl.2013.550.

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AbstractThe crystal structure of a-plane GaN/ZnO heterostructures on r-plane sapphire was investigated by using the XRD and TEM measurment. It was found the formation of (220) ZnGa2O4 and crystal orientation of semipolar (10$\bar 1$3) GaN at GaN/ZnO interface. The epitaxial relation of normal surface direction are the sapphire (1$\bar 1$02) // a-GaN (11$\bar 2$0) and ZnGa2O4 (220) // semi-polar GaN (10$\bar 1$$\bar 3$). Beside, the emission peak energy of ZnO appears shift about 60 meV in the GaN/ZnO/GaN heterostructures due to the re-crystallization of ZnO layer with Ga or N atom and the form

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Sun, Haoran, Yuhui Chen, Yuhao Ben, et al. "Influence of Low-Temperature Cap Layer Thickness on Luminescence Characteristics of Green InGaN/GaN Quantum Wells." Materials 16, no. 4 (2023): 1558. http://dx.doi.org/10.3390/ma16041558.

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GaN cap layer with different thicknesses was grown on each InGaN well layer during MOCVD growth for InGaN/GaN multiple quantum well (MQW) samples to study the influence of the cap layer on the photoluminescence (PL) characteristics of MQWs. Through the temperature-dependent (TD) PL spectra, it was found that when the cap layer was too thick, the localized states of the quantum wells were relatively non-uniform. The thicker the well layer, the worse the uniformity of the localized states. Furthermore, through micro-area fluorescence imaging tests, it was found that when the cap layer was too th

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3

Мохов, Е. Н., А. А. Вольфсон та О. П. Казарова. "Выращивание объёмных кристаллов AlN и GaN сублимационным сандвич-методом". Физика твердого тела 61, № 12 (2019): 2298. http://dx.doi.org/10.21883/ftt.2019.12.48537.17ks.

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The review of the results of growth of bulk Al and Ga nitride crystals on foreign substrates by the sublimation sandwich method (SSM) is presented. The kinetics and the mechanism of sublimation and condensation nitrides depending on the growth conditions, structure of the vapor phase, crystal orientation and the distance between the source and the seed are analyzed. It is experimentally established that by joint annealing of AlN and SiC the rate of AlN sublimation significantly increases due to formation of a liquid phase on the crystal surface. Non-uniform distribution of the liquid phase loc

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4

Ning, X. J., F. R. Chien, P. Pirouz, J. W. Yang, and M. Asif Khan. "Growth defects in GaN films on sapphire: The probable origin of threading dislocations." Journal of Materials Research 11, no. 3 (1996): 580–92. http://dx.doi.org/10.1557/jmr.1996.0071.

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Single crystal GaN films with a wurtzite structure were grown on the basal plane of sapphire. A high density of threading dislocations parallel to the c-axis crossed the film from the interface to the film surface. They were found to have a predominantly edge character with a Burgers vector. In addition, dislocation hal-loops, elongated along the c-axis of GaN, were also found on the prism planes. These dislocations had a mostly screw character with a [0001] Burgers vector. Substrate surface steps with a height of were found to be accommodated by localized elastic bending of GaN (0001)GaN plan

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5

Wang, C. K., Y. Z. Chiou, and H. J. Chang. "Investigating the Efficiency Droop of Nitride-Based Blue LEDs with Different Quantum Barrier Growth Rates." Crystals 9, no. 12 (2019): 677. http://dx.doi.org/10.3390/cryst9120677.

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In this study, GaN-based blue InGaN/GaN light-emitting diodes (LEDs) with different growth rates of the quantum barriers were fabricated and investigated. The LEDs with quantum barriers grown with a higher growth rate exhibit a lower leakage current and less non-radiative recombination centers in the multiple quantum wells (MQWs). Therefore, the LED with a higher barrier growth rate achieves a better light output power by 18.4% at 120 mA, which is attributed to weaker indium fluctuation effect in the QWs. On the other hand, the localized states created by indium fluctuation lead to a higher lo

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Yan, Luyi, Feng Liang, Jing Yang, Ping Chen, Desheng Jiang, and Degang Zhao. "The Influence Mechanism of Quantum Well Growth and Annealing Temperature on In Migration and Stress Modulation Behavior." Nanomaterials 14, no. 8 (2024): 703. http://dx.doi.org/10.3390/nano14080703.

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This study explores the effects of growth temperature of InGaN/GaN quantum well (QW) layers on indium migration, structural quality, and luminescence properties. It is found that within a specific range, the growth temperature can control the efficiency of In incorporation into QWs and strain energy accumulated in the QW structure, modulating the luminescence efficiency. Temperature-dependent photoluminescence (TDPL) measurements revealed a more pronounced localized state effect in QW samples grown at higher temperatures. Moreover, a too high annealing temperature will enhance indium migration

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7

El Amrani, Mohammed, Julien Buckley, Thomas Kaltsounis, et al. "Study of Leakage Current Transport Mechanisms in Pseudo-Vertical GaN-on-Silicon Schottky Diode Grown by Localized Epitaxy." Crystals 14, no. 6 (2024): 553. http://dx.doi.org/10.3390/cryst14060553.

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In this work, a GaN-on-Si quasi-vertical Schottky diode was demonstrated on a locally grown n-GaN drift layer using Selective Area Growth (SAG). The diode achieved a current density of 2.5 kA/cm2, a specific on-resistance RON,sp of 1.9 mΩ cm2 despite the current crowding effect in quasi-vertical structures, and an on/off current ratio (Ion/Ioff) of 1010. Temperature-dependent current–voltage characteristics were measured in the range of 313–433 K to investigate the mechanisms of leakage conduction in the device. At near-zero bias, thermionic emission (TE) was found to dominate. By increasing u

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Savini, G., M. I. Heggie, C. P. Ewels, N. Martsinovich, R. Jones, and A. T. Blumenau. "Structure and Energy of the 90° Partial Dislocations in Wurtzite-GaN." Materials Science Forum 483-485 (May 2005): 1057–60. http://dx.doi.org/10.4028/www.scientific.net/msf.483-485.1057.

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90 Shockley partial dislocations in GaN are investigated by first-principles calculations. This work is focussed on the electrical properties of dislocation cores, and on investigating the electrical fields around these defects. The band structure analysis shows that both the and core partials possess a midgap state. The -core dislocations give rise to a donor level Ev +0:87 eV that might explain the absorption peak at 2.4 eV revealed by energy loss spectroscopy measurements. The acceptor level Ev + 1:11 eV localized at the -core dislocations might contribute to the yellow luminescence. These

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SURESH, S., V. GANESH, M. BALAJI, K. BASKAR, K. ASOKAN, and D. KANJILAL. "STRUCTURAL CHARACTERISTICS OF 70 MeV Si5+ ION IRRADIATION INDUCED NANOCLUSTERS OF GALLIUM NITRIDE." International Journal of Nanoscience 10, no. 04n05 (2011): 823–26. http://dx.doi.org/10.1142/s0219581x11009246.

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70 MeV Si ions irradiation at the liquid nitrogen temperature (77 K) induced nanoclustering on GaN epilayers grown by Metal Organic Chemical Vapor Deposition (MOCVD) are reported. HRXRD rocking curves show that there are no localized amorphization due to irradiation. Atomic force microscopy images reveal the formation of nanoclusters on the surface of the irradiated samples. On increasing the fluence the number of modified regions on the surface increases and resulted in three dimensional growth of nanocluster due to overlapping and coalescence. X-ray photoelectron spectroscopy (XPS) studies c

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10

Bassaler, Julien, Rémi Comyn, Catherine Bougerol, Yvon Cordier, Farid Medjdoub, and Philippe Ferrandis. "Transport properties of a thin GaN channel formed in an Al_0.9Ga_0.1N/GaN heterostructure grown on AlN/sapphire template." Journal of Applied Physics 131, no. 12 (2022): 124501. http://dx.doi.org/10.1063/5.0077107.

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Despite a high lateral breakdown voltage above 10 kV for large contact distances and a breakdown field of 5 MV cm−1 for short contact distances, an Al0.9Ga0.1N/GaN heterostructure with an 8 nm strained GaN channel grown on an AlN/sapphire template suffers from a low and anisotropic mobility. This work deals with a material study to elucidate this issue. Threading dislocations were observed along the growth direction in transmission electron microscopy pictures and are more in number in the (11−20) plane. Steps were also detected in this plane at the GaN channel interfaces. With the help of dev

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11

Shi, Kaiju, Chengxin Wang, Rui Li, et al. "Influence of in volatilization on photoluminescence in InGaN/GaN multiple quantum wells." Materials Express 11, no. 12 (2021): 2033–38. http://dx.doi.org/10.1166/mex.2021.2105.

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Two multiple quantum well (MQW) InGaN/GaN structures emitting green light, without (A) and with (B) an indium (In) volatilization suppression technique (IVST) during growth of the active region, were fabricated. The dependencies of the photoluminescence (PL) spectra upon temperature at different levels of excitation power were investigated. The results indicate that an IVST can increase the In content while suppressing the phase separation caused by volatilization of that In incorporated in the well layers. Also, compared with Structure B with IVST, which contains one phase structure, Structur

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Kocmarek, Andrea L., Moira M. Ferguson, and Roy G. Danzmann. "Co-localization of growth QTL with differentially expressed candidate genes in rainbow trout." Genome 58, no. 9 (2015): 393–403. http://dx.doi.org/10.1139/gen-2015-0047.

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We tested whether genes differentially expressed between large and small rainbow trout co-localized with familial QTL regions for body size. Eleven chromosomes, known from previous work to house QTL for weight and length in rainbow trout, were examined for QTL in half-sibling families produced in September (1 XY male and 1 XX neomale) and December (1 XY male). In previous studies, we identified 108 candidate genes for growth expressed in the liver and white muscle in a subset of the fish used in this study. These gene sequences were BLASTN aligned against the rainbow trout and stickleback geno

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13

Fages, C., M. Kaksonen, T. Kinnunen, E. L. Punnonen, and H. Rauvala. "Regulation of mRNA localization by transmembrane signalling: local interaction of HB-GAM (heparin-binding growth-associated molecule) with the cell surface localizes beta-actin mRNA." Journal of Cell Science 111, no. 20 (1998): 3073–80. http://dx.doi.org/10.1242/jcs.111.20.3073.

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Localization of mRNAs is currently thought to be partially responsible for molecular sorting to specific compartments within the cell. In mammalian cells the best-studied example is the beta-actin mRNA that is localized to the cell processes, and its localization is necessary in migratory responses of cells. It is reasonable to assume that mRNA localization within cells is coupled to transmembrane signalling due to extracellular factors, but little is known about such putative mechanisms. We show here that HB-GAM, an extracellular matrix-associated factor that enhances migratory responses in c

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14

Fages, Carole, Marko Kaksonen, Tarja Kinnunen, Eeva-Liisa Punnonen та Heikki Rauvala. "Regulation of mRNA localization by transmembrane signalling: Local interaction of HB-GAM (heparin-binding growth-associated molecule) with the cell surface localizes β-actin mRNA". Journal of Cell Science 111, № 20 (1998): 3073–80. http://dx.doi.org/10.1242/jcs.20.111.3073.

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ABSTRACT Localization of mRNAs is currently thought to be partially responsible for molecular sorting to specific compartments within the cell. In mammalian cells the best-studied example is the β-actin mRNA that is localized to the cell processes, and its localization is necessary in migratory responses of cells. It is reasonable to assume that mRNA localization within cells is coupled to transmembrane signalling due to extracellular factors, but little is known about such putative mechanisms. We show here that HB- GAM, an extracellular matrix-associated factor that enhances migratory respons

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15

Cherubini, S., M. D. De Tullio, P. De Palma, and G. Pascazio. "Transient growth in the flow past a three-dimensional smooth roughness element." Journal of Fluid Mechanics 724 (May 8, 2013): 642–70. http://dx.doi.org/10.1017/jfm.2013.177.

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AbstractThis work provides a global optimization analysis, looking for perturbations inducing the largest energy growth at a finite time in a boundary-layer flow in the presence of smooth three-dimensional roughness elements. Amplification mechanisms are described which can bypass the asymptotical growth of Tollmien–Schlichting waves. Smooth axisymmetric roughness elements of different height have been studied, at different Reynolds numbers. The results show that even very small roughness elements, inducing only a weak deformation of the base flow, can localize the optimal disturbance characte

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Radin, Ivan, Ryan A. Richardson, Joshua H. Coomey, et al. "Plant PIEZO homologs modulate vacuole morphology during tip growth." Science 373, no. 6554 (2021): 586–90. http://dx.doi.org/10.1126/science.abe6310.

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In animals, PIEZOs are plasma membrane–localized cation channels involved in diverse mechanosensory processes. We investigated PIEZO function in tip-growing cells in the moss Physcomitrium patens and the flowering plant Arabidopsis thaliana. PpPIEZO1 and PpPIEZO2 redundantly contribute to the normal growth, size, and cytoplasmic calcium oscillations of caulonemal cells. Both PpPIEZO1 and PpPIEZO2 localized to vacuolar membranes. Loss-of-function, gain-of-function, and overexpression mutants revealed that moss PIEZO homologs promote increased complexity of vacuolar membranes through tubulation,

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Yu, Qin, та Ivan Stamenkovic. "Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-β and promotes tumor invasion and angiogenesis". Genes & Development 14, № 2 (2000): 163–76. http://dx.doi.org/10.1101/gad.14.2.163.

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We have uncovered a novel functional relationship between the hyaluronan receptor CD44, the matrix metalloproteinase-9 (MMP-9) and the multifunctional cytokine TGF-β in the control of tumor-associated tissue remodeling. CD44 provides a cell surface docking receptor for proteolytically active MMP-9 and we show here that localization of MMP-9 to cell surface is required for its ability to promote tumor invasion and angiogenesis. Our observations also indicate that MMP-9, as well as MMP-2, proteolytically cleaves latent TGF-β, providing a novel and potentially important mechanism for TGF-β activa

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18

Corso, Massimiliano, Fabrizio G. Doccula, J. Romário F. de Melo, Alex Costa, and Nathalie Verbruggen. "Endoplasmic reticulum-localized CCX2 is required for osmotolerance by regulating ER and cytosolic Ca2+ dynamics in Arabidopsis." Proceedings of the National Academy of Sciences 115, no. 15 (2018): 3966–71. http://dx.doi.org/10.1073/pnas.1720422115.

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Ca2+ signals in plant cells are important for adaptive responses to environmental stresses. Here, we report that the Arabidopsis CATION/Ca2+ EXCHANGER2 (CCX2), encoding a putative cation/Ca2+ exchanger that localizes to the endoplasmic reticulum (ER), is strongly induced by salt and osmotic stresses. Compared with the WT, AtCCX2 loss-of-function mutant was less tolerant to osmotic stress and displayed the most noteworthy phenotypes (less root/shoot growth) during salt stress. Conversely, AtCCX2 gain-of-function mutants were more tolerant to osmotic stress. In addition, AtCCX2 partially suppres

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Simionescu-Bankston, Adriana, Christophe Pichavant, James P. Canner, et al. "Creatine kinase B is necessary to limit myoblast fusion during myogenesis." American Journal of Physiology-Cell Physiology 308, no. 11 (2015): C919—C931. http://dx.doi.org/10.1152/ajpcell.00029.2015.

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Myoblast fusion is critical for proper muscle growth and regeneration. During myoblast fusion, the localization of some molecules is spatially restricted; however, the exact reason for such localization is unknown. Creatine kinase B (CKB), which replenishes local ATP pools, localizes near the ends of cultured primary mouse myotubes. To gain insights into the function of CKB, we performed a yeast two-hybrid screen to identify CKB-interacting proteins. We identified molecules with a broad diversity of roles, including actin polymerization, intracellular protein trafficking, and alternative splic

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Mitsiadis, T. A., M. Salmivirta, T. Muramatsu, et al. "Expression of the heparin-binding cytokines, midkine (MK) and HB-GAM (pleiotrophin) is associated with epithelial-mesenchymal interactions during fetal development and organogenesis." Development 121, no. 1 (1995): 37–51. http://dx.doi.org/10.1242/dev.121.1.37.

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Midkine (MK) and heparin binding-growth associated molecule (HB-GAM or pleiotrophin), constitute a new family of heparin-binding proteins implicated in the regulation of growth and differentiation (T. Muramatsu (1993) Int. J. Dev. Biol. 37, 183–188). We used affinity-purified antibodies against MK and HB-GAM to analyze their distribution during mouse embryonic development. From 9 to 14.5 day post-coitum (dpc), both proteins were detected in central and peripheral nervous systems, facial processes, limb buds, sense organs, respiratory, digestive, urogenital, and skeletal systems. MK and HB-GAM

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Duffaud, Florence, and Axel Le Cesne. "Recent advances in managing gastrointestinal stromal tumor." F1000Research 6 (September 14, 2017): 1689. http://dx.doi.org/10.12688/f1000research.11118.1.

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Constitutive activating mutations inKITand platelet-derived growth factor receptor α (PDGFRα) are heavily involved in the pathobiology of gastrointestinal stromal tumors (GISTs). This disease has served as an effective “proof-of-concept” model for targeting gain-of-function kinase mutations in cancer. This review discusses the current standard of care in terms of pharmacotherapy in the management of localized and metastatic GISTs.

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Bassuk, Anna Perkins Nina. "031 EFFECT OF BLANCHING, IBA CONCENTRATION, AND PLANT GROWTH REGULATORS ON GROWTH AND OVERWINTER SURVIVAL OF CUTTING-PROPAGATED ORNAMENTALS." HortScience 29, no. 5 (1994): 432b—432. http://dx.doi.org/10.21273/hortsci.29.5.432b.

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Budbreak inhibition and poor overwinter survival (OS) limit successful cutting propagation of Acer rubrum October Glory, A. rubrum Red Sunset, Hamamelis vernalis, H. virginiana and Stewartia pseudocamellia. Localized blanching (banding) of the cutting on the stock plant; a range of 3 IBA concentrations, and foliar spray application of: 1% silver thiosulfate(STS), STS followed ten days later by Gibberellin, GA4/7:250ppm(STS GA),50ppm thidiazuron (TDZ) and TDZ followed by GA4/7 (TDZ GA)were tested for increasing growth and overwinter survival.. Carbohydrates were analyzed in cuttings which did a

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23

Schrick, Kathrin, Ulrike Mayer, Andrea Horrichs, et al. "FACKEL is a sterol C-14 reductase required for organized cell division and expansion in Arabidopsis embryogenesis." Genes & Development 14, no. 12 (2000): 1471–84. http://dx.doi.org/10.1101/gad.14.12.1471.

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In flowering plants, the developing embryo consists of growing populations of cells whose fates are determined in a position-dependent manner to form the adult organism. Mutations in the FACKEL(FK) gene affect body organization of theArabidopsis seedling. We report that FK is required for cell division and expansion and is involved in proper organization of the embryo. We isolated FK by positional cloning. Expression analysis in embryos revealed that FK mRNA becomes localized to meristematic zones. FK encodes a predicted integral membrane protein related to the vertebrate lamin B receptor and

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Wang, Luyao, Ying Gui, Bingye Yang, et al. "Mitogen-Activated Protein Kinases Associated Sites of Tobacco Repression of Shoot Growth Regulates Its Localization in Plant Cells." International Journal of Molecular Sciences 23, no. 16 (2022): 8941. http://dx.doi.org/10.3390/ijms23168941.

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Plant defense and growth rely on multiple transcriptional factors (TFs). Repression of shoot growth (RSG) is a TF belonging to a bZIP family in tobacco, known to be involved in plant gibberellin feedback regulation by inducing the expression of key genes. The tobacco calcium-dependent protein kinase CDPK1 was reported to interact with RSG and manipulate its intracellular localization by phosphorylating Ser-114 of RSG previously. Here, we identified tobacco mitogen-activated protein kinase 3 (NtMPK3) as an RSG-interacting protein kinase. Moreover, the mutation of the predicted MAPK-associated p

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Bimberg, D., M. Grundmann, and N. N. Ledentsov. "Growth, Spectroscopy, and Laser Application of Self-Ordered III-V Quantum Dots." MRS Bulletin 23, no. 2 (1998): 31–34. http://dx.doi.org/10.1557/s0883769400031249.

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The development and application of semiconductor light-emitting and laser diodes has been a huge success during the last 30 years in key areas of modern technology like communications, recording, and printing. Still there is ample room for improvement through combination of the atomlike properties for zero-dimensionally localized carriers in quantum dots (QDs) with state-of-the-art semiconductor-laser technology. Low, temperature-insensitive threshold current; high gain; and differential gain have been predicted since the early 1980s.In the past two decades, the fabrication of QDs has been att

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Emerman, Joanne T., Nancy Jones, and Eveline E. Fiedler. "Glycosaminoglycan accumulation by normal and malignant human mammary epithelial cells in primary culture." Biochemistry and Cell Biology 66, no. 4 (1988): 309–18. http://dx.doi.org/10.1139/o88-040.

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The effects of glycosaminoglycans (GAGs) on cell growth and differentiation appear to vary with cell type and stage of development. This study describes the types and distribution of GAGs accumulated by normal and malignant human mammary epithelial cells in primary culture during their exponential and stationary phases of growth. Cultures incubated with [3H]glucosamine or [35S]sulfate were separated into medium, extracellular matrix (ECM), and cell fractions. Labelled GAGs were identified by chemical and enzymatic degradations and cellulose acetate electrophoresis. Cultures of normal cells in

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Basile, D. P., J. M. Rovak, D. R. Martin, and M. R. Hammerman. "Increased transforming growth factor-beta 1 expression in regenerating rat renal tubules following ischemic injury." American Journal of Physiology-Renal Physiology 270, no. 3 (1996): F500—F509. http://dx.doi.org/10.1152/ajprenal.1996.270.3.f500.

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To gain insight into the role that transforming growth factor-beta 1 (TGF-beta 1) plays in the regeneration of kidneys following acute renal failure, we characterized the expression of TGF-beta 1 mRNA and the expression of active and latent TGF-beta peptide at various times during recovery from acute ischemic injury in rat. Levels of whole kidney TGF-beta 1 mRNA were elevated significantly at 12 h postinjury (1.5-fold vs. sham-operated controls), and by 24 h postinjury were elevated by 3.6-fold. Levels remained elevated for 14 days following ischemia, but were no longer elevated at 28 days pos

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Morrison, Huntly M., Julia Craft, Rafael Rivera-Lugo, et al. "Deficiency in Galectin-3, -8, and -9 impairs immunity to chronic Mycobacterium tuberculosis infection but not acute infection with multiple intracellular pathogens." PLOS Pathogens 19, no. 6 (2023): e1011088. http://dx.doi.org/10.1371/journal.ppat.1011088.

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Macrophages employ an array of pattern recognition receptors to detect and eliminate intracellular pathogens that access the cytosol. The cytosolic carbohydrate sensors Galectin-3, -8, and -9 (Gal-3, Gal-8, and Gal-9) recognize damaged pathogen-containing phagosomes, and Gal-3 and Gal-8 are reported to restrict bacterial growth via autophagy in cultured cells. However, the contribution of these galectins to host resistance during bacterial infection in vivo remains unclear. We found that Gal-9 binds directly to Mycobacterium tuberculosis (Mtb) and Salmonella enterica serovar Typhimurium (Stm)

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Bera, Smritilekha, and Dhananjoy Mondal. "Click-Chemistry-Assisted Alteration of Glycosaminoglycans for Biological Applications." SynOpen 07, no. 02 (2023): 277–89. http://dx.doi.org/10.1055/s-0040-1720072.

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AbstractThis short review describes the assistance of click chemistry in the chemical modification of glycosaminoglycans. Through an alkyne-azide 1,3-dipolar cycloaddition reaction, the chemically and physiologically stable triazole unit connects glycosaminoglycans with other labelled or attached functionalities. The synthesized glycosaminoglycan (GAG) conjugates act as drug carriers, forming hydrogels or nanohydrogels for localized drug delivery or injectable GAGs and so on. These are used in research on antithrombotic agents, protein binding, and hepatocyte growth factors, as well as in mech

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Virkola, Ritva, Mirko Brummer, Heikki Rauvala, Loek van Alphen, and Timo K. Korhonen. "Interaction of Fimbriae of Haemophilus influenzae Type B with Heparin-Binding Extracellular Matrix Proteins." Infection and Immunity 68, no. 10 (2000): 5696–701. http://dx.doi.org/10.1128/iai.68.10.5696-5701.2000.

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ABSTRACT The interaction of the fimbriae of Haemophilus influenzae type b (Hib) with two heparin-binding extracellular matrix proteins, human fibronectin (Fn) and heparin-binding growth-associated molecule (HB-GAM) from mouse, were studied. The fimbriated Hib strain 770235 fim+, as well as the recombinant strainE. coli HB101(pMH140), which expressed Hib fimbriae, adhered strongly to Fn and HB-GAM immobilized on glass. Purified Hib fimbriae bound to Fn and HB-GAM, and within the Fn molecule, the binding was localized to the N-terminal 30,000-molecular-weight (30K) and 40K fragments, which conta

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Wishart, Tayler F. L., and Frank J. Lovicu. "Spatiotemporal Localisation of Heparan Sulphate Proteoglycans throughout Mouse Lens Morphogenesis." Cells 12, no. 10 (2023): 1364. http://dx.doi.org/10.3390/cells12101364.

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Heparan sulphate proteoglycans (HSPGs) consist of a core protein decorated with sulphated HS-glycosaminoglycan (GAG) chains. These negatively charged HS-GAG chains rely on the activity of PAPSS synthesising enzymes for their sulfation, which allows them to bind to and regulate the activity of many positively charged HS-binding proteins. HSPGs are found on the surfaces of cells and in the pericellular matrix, where they interact with various components of the cell microenvironment, including growth factors. By binding to and regulating ocular morphogens and growth factors, HSPGs are positioned

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Rodriguez, Isaac A., Emily A. Growney Kalaf, Gary L. Bowlin, and Scott A. Sell. "Platelet-Rich Plasma in Bone Regeneration: Engineering the Delivery for Improved Clinical Efficacy." BioMed Research International 2014 (2014): 1–15. http://dx.doi.org/10.1155/2014/392398.

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Human bone is a tissue with a fairly remarkable inherent capacity for regeneration; however, this regenerative capacity has its limitations, and defects larger than a critical size lack the ability to spontaneously heal. As such, the development and clinical translation of effective bone regeneration modalities are paramount. One regenerative medicine approach that is beginning to gain momentum in the clinical setting is the use of platelet-rich plasma (PRP). PRP therapy is essentially a method for concentrating platelets and their intrinsic growth factors to stimulate and accelerate a healing

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ТАРАНЕНКО, А. В., Л. С. БАСАЛАЕВА, В. В. ФЁДОРОВ, В. С. ТУМАШЕВ, and А. Г. МИЛЁХИН. "SURFACE-ENHANCED RAMAN SCATTERING FROM GAP NANOWIRES WITH A GALLIUM DROPLET." Автометрия 60, no. 4 (2024): 93–100. http://dx.doi.org/10.15372/aut20240410.

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Представлены результаты исследования структурных и оптических свойств массивов и одиночных нанопроволок (НП) GaP ориентации (111) с помощью спектроскопии комбинационного рассеяния света (КРС) и атомно-силовой микроскопии (АСМ). Массивы НП GaP были выращены на подложке Si(111) методом самокаталитического роста по механизму пар - жидкость - кристалл. Одиночные НП GaP были механически перенесены на золотую поверхность. В спектрах КРС НП GaP наблюдались моды поперечных (TO), продольных (LO) и поверхностных (SO) оптических фононов. Обнаружено поверхностно-усиленное КРС фононными модами GaP вблизи г

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Passaggia, Pierre-Yves, Karl R. Helfrich, and Brian L. White. "Optimal transient growth in thin-interface internal solitary waves." Journal of Fluid Mechanics 840 (February 12, 2018): 342–78. http://dx.doi.org/10.1017/jfm.2018.19.

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The dynamics of perturbations to large-amplitude internal solitary waves (ISWs) in two-layered flows with thin interfaces is analysed by means of linear optimal transient growth methods. Optimal perturbations are computed through direct–adjoint iterations of the Navier–Stokes equations linearized around inviscid, steady ISWs obtained from the Dubreil-Jacotin–Long (DJL) equation. Optimal perturbations are found as a function of the ISW phase velocity $c$ (alternatively amplitude) for one representative stratification. These disturbances are found to be localized wave-like packets that originate

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Basile-Borgia, Annette E., and Vassie C. Ware. "Life and death of a cardiac myocyte: principles of cellular biology." Perfusion 16, no. 3 (2001): 229–41. http://dx.doi.org/10.1177/026765910101600309.

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If the future of extracorporeal circulation is to include approaches to enhance localized or widespread distribution of cells, and/or gene transfer for augmentation of cardiac function, it is imperative that we gain an increased understanding of the mechanisms that define the cardiac myocyte phenotype. The purpose of this paper is to review the natural history of the cardiac myocyte. A variety of signals determine the cellular processes that characterize birth, growth, differentiation and death of cardiomyocytes. Examined here are primary aspects of the molecular genetics of growth and develop

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Avola, Danilo, Irene Cannistraci, Marco Cascio, et al. "A Novel GAN-Based Anomaly Detection and Localization Method for Aerial Video Surveillance at Low Altitude." Remote Sensing 14, no. 16 (2022): 4110. http://dx.doi.org/10.3390/rs14164110.

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The last two decades have seen an incessant growth in the use of Unmanned Aerial Vehicles (UAVs) equipped with HD cameras for developing aerial vision-based systems to support civilian and military tasks, including land monitoring, change detection, and object classification. To perform most of these tasks, the artificial intelligence algorithms usually need to know, a priori, what to look for, identify. or recognize. Actually, in most operational scenarios, such as war zones or post-disaster situations, areas and objects of interest are not decidable a priori since their shape and visual feat

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Park, Kiwan, Sunghee Jun, Jerry Jisang Han, Jiyoung Lee, Hwain Kim, and Joonkyung Kim. "Caffé Bene Disrupts the Stagnating Korean Coffee Shop Market." Asian Case Research Journal 19, no. 01 (2015): 203–30. http://dx.doi.org/10.1142/s021892751550008x.

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Caffé Bene was founded in 2007, during which the coffee shop market in Korea had been experiencing rapid growth. Caffé Bene had to compete with existing brands, including Starbucks, The Coffee Bean and Tea Leaf, and other coffee shop chains native to Korea. Sun-Kwon Kim, the founder and current CEO of Caffé Bene, tried to differentiate his brand on the basis of a new concept of European ambience mixed with Korean culture, new and localized menus, and celebrity endorsements; all of which were unheard of in the retail coffee industry at that time. This novel approach allowed Caffé Bene to gain g

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Li, Hui, Jinbo Hu, Jing Pang, et al. "Rho GTPase ROP1 Interactome Analysis Reveals Novel ROP1-Associated Pathways for Pollen Tube Polar Growth in Arabidopsis." International Journal of Molecular Sciences 21, no. 19 (2020): 7033. http://dx.doi.org/10.3390/ijms21197033.

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ROP (Rho-like GTPases from plants) GTPases are polarly localized key regulators of polar growth in pollen tubes and other cells in plants. However, how ROP GTPases are regulated and how they control polar growth remains to be fully understood. To gain new insights into ROP-dependent mechanisms underlying polar cell growth, we characterized the interactome of ROP1 GTPase that controls Arabidopsis pollen tube (PT) tip growth, an extreme form of polar cell growth. We established an efficient method for culturing Arabidopsis pollen tubes in liquid medium, which was used for immunoprecipitation/mas

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Kamikura, Darren M., Hanane Khoury, Christiane Maroun, Monica A. Naujokas, and Morag Park. "Enhanced Transformation by a Plasma Membrane-Associated Met Oncoprotein: Activation of a Phosphoinositide 3′-Kinase-Dependent Autocrine Loop Involving Hyaluronic Acid and CD44." Molecular and Cellular Biology 20, no. 10 (2000): 3482–96. http://dx.doi.org/10.1128/mcb.20.10.3482-3496.2000.

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ABSTRACT A Met-hepatocyte growth factor receptor oncoprotein, Tpr-Met, generated by chromosomal rearrangement, fuses a protein dimerization motif with the cytoplasmic domain of the Met receptor, producing a cytosolic, constitutively activated tyrosine kinase. Although both the Met receptor and the Tpr-Met oncoprotein associate with the same substrates, activating mutations of the Met receptor in hereditary papillary renal carcinomas have different signaling requirements for transformation than Tpr-Met. This suggests differential activation of membrane-localized pathways by oncogenic forms of t

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Pan, Jing, Jing Zhang, Andrew Hill та ін. "A Kinome-Wide siRNA Screen Identifies Multiple Roles for Protein Kinases in Hypoxic Stress Adaptation, Including Roles for IRAK4 and GAK in Protection against Apoptosis in VHL−/− Renal Carcinoma Cells, Despite Activation of the NF-κB Pathway". Journal of Biomolecular Screening 18, № 7 (2013): 782–96. http://dx.doi.org/10.1177/1087057113484803.

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Hypoxia induces changes to cancer cells that make them more resistant to treatment. We have looked at signaling pathways that facilitate these changes by screening the human kinome for effects on hypoxic responses in SW480 colon cancer cells. Hits identified in the screen were examined for effects on multiple molecular responses to hypoxia, including the endoplasmic reticulum stress and DNA damage responses in colon, melanoma, and renal cancer lines. To validate the hits from the small interfering RNA studies, we developed cell lines expressing stable short hairpin RNAs (shRNAs) in the A498 re

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Dini, Pouya, Mariano Carossino, Udeni B. R. Balasuriya, et al. "Paternally expressed retrotransposon Gag-like 1 gene, RTL1, is one of the crucial elements for placental angiogenesis in horses." Biology of Reproduction 104, no. 6 (2021): 1386–99. http://dx.doi.org/10.1093/biolre/ioab039.

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Abstract RTL1 (retrotransposon Gag-like 1) is an essential gene in the development of the human and murine placenta. Several fetal and placental abnormalities such as intrauterine growth restriction (IUGR) and hydrops conditions have been associated with altered expression of this gene. However, the function of RTL1 has not been identified. RTL1 is located on a highly conserved region in eutherian mammals. Therefore, the genetic and molecular analysis in horses could hold important implications for other species, including humans. Here, we demonstrated that RTL1 is paternally expressed and is

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Rohan, R. M., T. G. Unterman, L. Liu, and M. K. Hise. "Expression of the insulin-like growth factor system in the hypokalemic rat kidney." American Journal of Physiology-Renal Physiology 272, no. 5 (1997): F661—F667. http://dx.doi.org/10.1152/ajprenal.1997.272.5.f661.

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We studied the renal expression of the insulin-like growth factor (IGF) system to gain a better perspective of its potential role in the hyperplastic adaptation of the distal nephron to potassium deficiency. Rats were pair fed 1% or 0.002% potassium diets for periods up to 10 days. IGF-I mRNA was diminished in potassium-deficient rats within 4 days, whereas mRNA for IGF binding protein-1 (IGFBP-1), a collecting duct-associated protein, was increased by day 7. At day 10 mRNA for IGFBP-1 in potassium-deficient animals averaged 2.07 +/- 0.53 (mean +/- SD, relative densitometry units) compared wit

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Wong, Howard, Jung Soh, Paul M. K. Gordon, et al. "Genomic compartmentalization of gene families encoding core components of metazoan signaling systems." Genome 56, no. 4 (2013): 215–25. http://dx.doi.org/10.1139/gen-2013-0021.

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To investigate the role of gene localization and genome organization in cell–cell signalling and regulation, we mapped the distribution pattern of gene families that comprise core components of intercellular communication networks. Our study is centered on the distinct evolutionarily conserved metazoan signalling pathways that employ proteins in the receptor tyrosine kinase, WNT, hedgehog, NOTCH, Janus kinase/STAT, transforming growth factor beta, and nuclear hormone receptor protein families. Aberrant activity of these signalling pathways is closely associated with the promotion and maintenan

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Bellou, Sofia, Mark A. Hink, Eleni Bagli, et al. "VEGF autoregulates its proliferative and migratory ERK1/2 and p38 cascades by enhancing the expression of DUSP1 and DUSP5 phosphatases in endothelial cells." American Journal of Physiology-Cell Physiology 297, no. 6 (2009): C1477—C1489. http://dx.doi.org/10.1152/ajpcell.00058.2009.

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Vascular endothelial growth factor (VEGF) is a key angiogenic factor that regulates proliferation and migration of endothelial cells via phosphorylation of extracellular signal-regulated kinase-1/2 (ERK1/2) and p38, respectively. Here, we demonstrate that VEGF strongly induces the transcription of two dual-specificity phosphatase (DUSP) genes DUSP1 and DUSP5 in endothelial cells. Using fluorescence microscopy, fluorescence lifetime imaging (FLIM), and fluorescence cross-correlation spectroscopy (FCCS), we found that DUSP1/mitogen-activated protein kinases phosphatase-1 (MKP-1) was localized in

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Molloy, Andrew. "Second Growth: Community Economic Development in Rural British Columbia." Canadian Journal of Political Science 38, no. 4 (2005): 1067–68. http://dx.doi.org/10.1017/s0008423905249971.

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Second Growth: Community Economic Development in Rural British Columbia, Sean Markey, John Pierce, Mark Roseland and Kelly Vodden, Vancouver: University of British Columbia Press, 2005, pp. 352.This theoretically rich, community economic development (CED) work, written by four members of the Centre for Sustainable Community Development (formerly the Community Economic Development Centre) at Simon Fraser University, is the product of a three-year participatory-action-based research project involving four “forest-based” British Columbia communities. Two Aboriginal communities and two municipalit

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Al-Gizawiy, Mona, Robert T. Wujek, Casey J. Zoss, et al. "ATRT-03. THE ORAL IRON-MIMETIC GALLIUM MALTOLATE INHIBITS ATRT IN VIVO – IMAGING AND HISTOLOGICAL CHARACTERIZATION." Neuro-Oncology 25, Supplement_1 (2023): i1. http://dx.doi.org/10.1093/neuonc/noad073.003.

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Abstract BACKGROUND Atypical teratoid rhabdoid tumor (ATRT) is a highly aggressive CNS tumor that is associated with poor outcome. This dire prognosis is due in part to its poor response to the limited treatment options available. Iron and iron proteins play a key role in the growth of many solid cancers, including brain tumors. Our published studies show that the ferrobiology of brain tumors can be exploited for therapeutic purposes. Here, we further demonstrate the inhibitory effects of oral gallium maltolate (GaM) in pediatric ATRT in vivo. METHODS Pediatric CHLA-266 ATRT cells were stereot

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Liang, Feng-Xia, Cai-Wang Ge, Teng-Fei Zhang, et al. "Plasmonic hollow gold nanoparticles induced high-performance Bi2S3 nanoribbon photodetector." Nanophotonics 6, no. 2 (2017): 494–501. http://dx.doi.org/10.1515/nanoph-2016-0024.

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AbstractA high performance hollow gold nanoparticles (HGNs) decorated one-dimensional (1-D) Bi2S3nanoribbon (NR) photodetector was fabricated for green light detection (560 nm). The single crystal 1-D Bi2S3NRs with growth orientation along [001] were synthesized by a simple solvothermal approach. Optoelectronic analysis reveals that the performance of the plasmonic photodetector was greatly enhanced after decoration with HGNs. For example, the responsivity increases from 1.4 × 102to 1.09 × 103AW−1, the conductivity gain from 2.68 × 102to 2.31 × 103, and the detectivity from 2.45 × 1012to 2.78

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Shang, Huihui, Panpan Li, Xiaobo Zhang, et al. "The Gain-of-Function Mutation, OsSpl26, Positively Regulates Plant Immunity in Rice." International Journal of Molecular Sciences 23, no. 22 (2022): 14168. http://dx.doi.org/10.3390/ijms232214168.

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Rice spotted-leaf mutants are ideal materials to study the molecular mechanism underlying programmed cell death and disease resistance in plants. LOC_Os07g04820 has previously been identified as the candidate gene responsible for the spotted-leaf phenotype in rice Spotted-leaf 26 (Spl26) mutant. Here, we cloned and validated that LOC_Os07g04820 is the locus controlling the spotted-leaf phenotype of Spl26 by reverse functional complementation and CRISPR/Cas9-mediated knockout of the mutant allele. The recessive wild-type spl26 allele (Oryza sativa spotted-leaf 26, Osspl26) is highly conservativ

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Kong, Ping, Carlos Gonzalez-Quesada, Na Li, Michele Cavalera, Dong-Wook Lee, and Nikolaos G. Frangogiannis. "Thrombospondin-1 regulates adiposity and metabolic dysfunction in diet-induced obesity enhancing adipose inflammation and stimulating adipocyte proliferation." American Journal of Physiology-Endocrinology and Metabolism 305, no. 3 (2013): E439—E450. http://dx.doi.org/10.1152/ajpendo.00006.2013.

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As a typical matricellular protein, thrombospondin (TSP)-1, binds to the structural matrix and regulates cellular behavior by modulating growth factor and cytokine signaling. Obesity and diabetes are associated with marked upregulation of TSP-1 in adipose tissue. We hypothesized that endogenous TSP-1 may play an important role in the pathogenesis of diet-induced obesity and metabolic dysfunction. Accordingly, we examined the effects of TSP-1 gene disruption on weight gain, adiposity, and adipose tissue inflammation in mice receiving a high-fat diet (HFD: 60% fat, 20% carbohydrate) or a high-ca

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Porco, Silvana, Aleš Pěnčík, Afaf Rashed, et al. "Dioxygenase-encoding AtDAO1 gene controls IAA oxidation and homeostasis in Arabidopsis." Proceedings of the National Academy of Sciences 113, no. 39 (2016): 11016–21. http://dx.doi.org/10.1073/pnas.1604375113.

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Auxin represents a key signal in plants, regulating almost every aspect of their growth and development. Major breakthroughs have been made dissecting the molecular basis of auxin transport, perception, and response. In contrast, how plants control the metabolism and homeostasis of the major form of auxin in plants, indole-3-acetic acid (IAA), remains unclear. In this paper, we initially describe the function of the Arabidopsis thaliana gene DIOXYGENASE FOR AUXIN OXIDATION 1 (AtDAO1). Transcriptional and translational reporter lines revealed that AtDAO1 encodes a highly root-expressed, cytopla

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