Academic literature on the topic 'Localized regulation'

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Journal articles on the topic "Localized regulation"

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Ishibashi, Yohei, Makoto Ito, and Yoshio Hirabayashi. "Regulation of glucosylceramide synthesis by Golgi-localized phosphoinositide." Biochemical and Biophysical Research Communications 499, no. 4 (2018): 1011–18. http://dx.doi.org/10.1016/j.bbrc.2018.04.039.

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Tsai, Albert, Rafael Galupa, and Justin Crocker. "Robust and efficient gene regulation through localized nuclear microenvironments." Development 147, no. 19 (2020): dev161430. http://dx.doi.org/10.1242/dev.161430.

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ABSTRACTDevelopmental enhancers drive gene expression in specific cell types during animal development. They integrate signals from many different sources mediated through the binding of transcription factors, producing specific responses in gene expression. Transcription factors often bind low-affinity sequences for only short durations. How brief, low-affinity interactions drive efficient transcription and robust gene expression is a central question in developmental biology. Localized high concentrations of transcription factors have been suggested as a possible mechanism by which to use th
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Hofmann, Nancy R. "Endoplasmic Reticulum–Localized Transcription Factors and Mitochondrial Retrograde Regulation." Plant Cell 25, no. 9 (2013): 3151. http://dx.doi.org/10.1105/tpc.113.250912.

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Ehrenheim, Alexander M., Alberto Vianelli, Giovanni Finazzi, and Giorgio Forti. "Regulation by localized protons of Photosystem II photochemical efficiency." Biochimica et Biophysica Acta (BBA) - Bioenergetics 1100, no. 3 (1992): 299–302. http://dx.doi.org/10.1016/0167-4838(92)90485-v.

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Dai, Shuiping, Duane D. Hall, and Johannes W. Hell. "Supramolecular Assemblies and Localized Regulation of Voltage-Gated Ion Channels." Physiological Reviews 89, no. 2 (2009): 411–52. http://dx.doi.org/10.1152/physrev.00029.2007.

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This review addresses the localized regulation of voltage-gated ion channels by phosphorylation. Comprehensive data on channel regulation by associated protein kinases, phosphatases, and related regulatory proteins are mainly available for voltage-gated Ca2+ channels, which form the main focus of this review. Other voltage-gated ion channels and especially Kv7.1-3 (KCNQ1-3), the large- and small-conductance Ca2+-activated K+ channels BK and SK2, and the inward-rectifying K+ channels Kir3 have also been studied to quite some extent and will be included. Regulation of the L-type Ca2+ channel Cav
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Kawanaka, Norikuni, and Andrew W. Taylor. "Localized retinal neuropeptide regulation of macrophage and microglial cell functionality." Journal of Neuroimmunology 232, no. 1-2 (2011): 17–25. http://dx.doi.org/10.1016/j.jneuroim.2010.09.025.

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Park, Jeong Hoan, Joanne Si Ying Tan, Han Wu, Yilong Dong, and Jerald Yoo. "1225-Channel Neuromorphic Retinal-Prosthesis SoC With Localized Temperature-Regulation." IEEE Transactions on Biomedical Circuits and Systems 14, no. 6 (2020): 1230–40. http://dx.doi.org/10.1109/tbcas.2020.3036091.

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Mao, Li-Min, and John Q. Wang. "Synaptically Localized Mitogen-Activated Protein Kinases: Local Substrates and Regulation." Molecular Neurobiology 53, no. 9 (2015): 6309–15. http://dx.doi.org/10.1007/s12035-015-9535-1.

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van Balkom, Bas W. M., Michael P. J. Graat, M. van Raak, Erik Hofman, Peter van der Sluijs, and Peter M. T. Deen. "Role of cytoplasmic termini in sorting and shuttling of the aquaporin-2 water channel." American Journal of Physiology-Cell Physiology 286, no. 2 (2004): C372—C379. http://dx.doi.org/10.1152/ajpcell.00271.2003.

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In mammals, the regulation of water homeostasis is mediated by the aquaporin-1 (AQP1) water channel, which localizes to the basolateral and apical membranes of the early nephron segment, and AQP2, which is translocated from intracellular vesicles to the apical membrane of collecting duct cells after vasopressin stimulation. Because a similar localization and regulation are observed in transfected Madin-Darby Canine Kidney (MDCK) cells, we investigated which segments of AQP2 are important for its routing to forskolin-sensitive vesicles and the apical membrane through analysis of AQP1-AQP2 chime
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Tamma, Grazia, Joris H. Robben, Christiane Trimpert, Michelle Boone, and Peter M. T. Deen. "Regulation of AQP2 localization by S256 and S261 phosphorylation and ubiquitination." American Journal of Physiology-Cell Physiology 300, no. 3 (2011): C636—C646. http://dx.doi.org/10.1152/ajpcell.00433.2009.

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Vasopressin-induced water reabsorption coincides with phosphorylation of aquaporin-2 (AQP2) at S256 (pS256), dephosphorylation at S261, and its translocation to the apical membrane, whereas treatment with the phorbol ester 12-tetradecanoylphorbol-13-acetate (TPA) induces AQP2 ubiquitination at K270, its internalization, and lysosomal degradation. In this study we investigated the relationship between S256 and S261 phosphorylation in AQP2 and its ubiquitination and trafficking in MDCK cells. Forskolin stimulation associated with increased pS256 and decreased pS261 AQP2, indicating that MDCK cel
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Dissertations / Theses on the topic "Localized regulation"

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Cho, Junkwon. "Nucleus-localized adiponectin is survival gatekeeper through miR-214-mediated AIFM2 regulation." Kyoto University, 2019. http://hdl.handle.net/2433/242427.

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Hagen, Brian M. "Regulation of calcium-activated potassium channels by localized calcium transients in murine colon." abstract and full text PDF (free order & download UNR users only), 2005. http://0-gateway.proquest.com.innopac.library.unr.edu/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3209955.

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Ban, Kenneth. "Localized regulation of the anaphase-promoting complex by the Emi1/NuMA/Dynein-dynactin (END) network /." May be available electronically:, 2007. http://proquest.umi.com/login?COPT=REJTPTU1MTUmSU5UPTAmVkVSPTI=&clientId=12498.

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Snetkova, Valentina. "Enhancers Cooperate to Exert Localized and Long-Range Control of Gene Regulation in Lymphocyte Development." Thesis, New York University, 2017. http://pqdtopen.proquest.com/#viewpdf?dispub=10258886.

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<p> Enhancers are regulatory elements that orchestrate cell type specific gene expression patterns. They can be separated from their target genes by large distances and activate transcription by coming into physical proximity with promoters in three-dimensional nuclear space. Complex regulatory networks with multiple enhancers often cooperate to control the same target gene. Antigen receptor loci have proved to be a rich ground for understanding enhancer-mediated gene regulation. The loci undergo somatic recombination of their V, (D), J segments to create a diverse repertoire of antigen recept
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Linne, Hannah Louise. "Investigating telomerase regulation in human breast cancer cells : a search for telomerase repressor sequences localised to chromosome 3P." Thesis, Brunel University, 2015. http://bura.brunel.ac.uk/handle/2438/11620.

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Cellular immortality is one of the ten hallmarks of human cancer and has been shown to be an essential prerequisite for malignant progression (Hanahan and Weinberg., 2011, Newbold et al., 1982, Newbold and Overell., 1983). In contrast, normal human somatic cells proliferate for a limited number of population doublings before entering permanent growth arrest known as replicative senescence. This is thought to be due to the progressive shortening of telomeric sequences with each round of cell division. Over 90% of human tumours, but not the majority of human somatic cells, have been found to exp
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Pigny, Pascal. "Les genes de mucines humaines localises en 11p15 ; polymorphisme, cartographie physique et approche de regulation." Lille 2, 1997. http://www.theses.fr/1997LIL2T003.

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Gillies, Laura. "The sphingosine 1 phosphate receptor 5 and sphingosine kinase 1 and 2 are localized in centrosomes : role in regulating cell division." Thesis, University of Strathclyde, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.501800.

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The bioactive lipid sphingosine-1-phosphate (SIP) has the unique characteristic of being capable of engaging in both paracrine/autocrine signalling and intracrine signalling pathways. Research into the latter has been limited by the failure to identify downstream targets for intracellular S1P. The majority of cellular responses to S1P are mediated by a family of G-protein coupled receptors (GPCR) known as S1P receptors: SIP₁₋₅. The current study demonstrates that SIP₅ and both sphingosine kinases (SPHK1 and SPHK2) exhibit a unique intracellular localization in the centrosome of mammalian cells
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Diongue, Momar. "Périurbanisation différentielle : mutations et réorganisation de l'espace à l'est de la région dakaroise (Diamniadio, Sangalkam, Yéné), Sénégal." Thesis, Paris 10, 2010. http://www.theses.fr/2010PA100076.

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L’objectif de cette thèse est d’analyser les relations entre périurbanisation et territorialisation autour d’une question principale, la gouvernance des espaces périurbains métropolitains. Dans les grandes villes ouest-africaines, ces espaces sont affectés par de rapides et multiples mutations dans un contexte de décentralisation accélérée. Pour analyser ces mutations et les dynamiques de régulation qu’elles suscitent, nous privilégions une approche territoriale comparative. Á l’échelle micro, il s’agit d’appréhender les dynamiques de la périurbanisation en s’interrogeant sur le poids des cont
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Tavares, Lucas Alves. "O envolvimento da proteína adaptadora 1 (AP-1) no mecanismo de regulação negativa do receptor CD4 por Nef de HIV-1." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/17/17136/tde-06012017-113215/.

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O Vírus da Imunodeficiência Humana (HIV) é o agente etiológico da Síndrome da Imunodeficiência Adquirida (AIDS). A AIDS é uma doença de distribuição mundial, e estima-se que existam atualmente pelo menos 36,9 milhões de pessoas infectadas com o vírus. Durante o seu ciclo replicativo, o HIV promove diversas alterações na fisiologia da célula hospedeira a fim de promover sua sobrevivência e potencializar a replicação. A rápida progressão da infecção pelo HIV-1 em humanos e em modelos animais está intimamente ligada à função da proteína acessória Nef. Dentre as diversas ações de Nef está a regula
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Johnson, Danielle Elaine. "pH changes localized to the surface of membrane transport proteins." Phd thesis, 2011. http://hdl.handle.net/10048/1697.

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Intracellular pH was monitored at the cytosolic surface of plasma membrane solute transporters (Na+/H+/nucleoside co-transporters, or Cl-/HCO3- exchangers), using pH-sensitive fluorescent proteins (FPs), dual emission green FP (deGFP4) and a monomeric red FP Nectarine (mNect), whose development and characterization are also reported here. Human concentrative nucleoside transporter, hCNT3, mediates Na+/H+/nucleoside co-transport. We describe a new approach to monitor H+/uridine co-transport in HEK293 cells. pH changes at the intracellular surface of hCNT3 were monitored by fusing mNect to the
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Books on the topic "Localized regulation"

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Crum, Brian A., Eduardo E. Benarroch, and Robert D. Brown. Neurologic Disorders Categorized by Anatomical Involvement. Oxford University Press, 2012. http://dx.doi.org/10.1093/med/9780199755691.003.0523.

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Neurological disorders of the brain, spine, and peripheral nervous system are examined. Symptoms and signs related to disorders of the cerebral cortex may lead to alterations in cognition and consciousness. Unilateral neurologic symptoms involving a single neurologic symptom commonly localize to the cerebral cortex. Abnormalities of speech and language are localized to the dominant cerebral hemisphere, whereas abnormalities of the nondominant hemisphere may lead to visuospatial deficits, confusion, or neglect of the contralateral side of the body. The hypothalamus is important in many function
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Tuschl, Karin, Peter T. Clayton, and Philippa B. Mills. Disorders of Manganese Metabolism. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199972135.003.0045.

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Manganese is an essential trace metal for numerous metalloenzymes. Manganese homeostasis requires tight regulation in vivo and disruption of this balance can lead to manganese overload and subsequent accumulation of manganese in brain, liver, and blood. Mutations in SLC30A10, a cell surface-localized manganese efflux transporter, cause an autosomal recessive hypermanganesemia syndrome with two distinct phenotypes: childhood onset dystonia and adult onset Parkinsonism, associated with chronic liver disease, polycythemia and features of iron depletion. MRI brain appearances are characteristic of
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Murer, Heini, Jürg Biber, and Carsten A. Wagner. Phosphate homeostasis. Edited by Robert Unwin. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199592548.003.0025.

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Inorganic phosphate ions (H2PO4−/ HPO42−) (abbreviated as Pi) are involved in formation of bone and generation of high-energy bonds (e.g. ATP), metabolic pathways, and regulation of cellular functions. In addition, Pi is a component of biological membranes and nucleic acids. Only about 1% of total body Pi content is present in extracellular fluids, at a plasma concentration in adults within the range 0.8–1.4 mMol/L (at pH 7.4 mostly as HPO42−), with diurnal variations of approximately 0.2 mM. A small amount of plasma Pi is bound to proteins or forms complexes with calcium. Under normal, balanc
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Taylor, Eric. Developmental Neuropsychiatry. Oxford University Press, 2021. http://dx.doi.org/10.1093/med/9780198827801.001.0001.

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Neurodevelopmental disorders are a group of conditions involving alterations of behaviour, thinking, and emotions. They have onsets in early childhood, persistence into adult life, and high rates of altered cognitive and neurological function. They are frequent reasons for referral to psychiatry, paediatrics, and clinical psychology and often require team approaches to meet a variety of needs for service. This book includes accounts of the typical development and possible pathology of key functions whose alterations can underlie problems of mental development: motor function, attention, memory
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Book chapters on the topic "Localized regulation"

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Venette, Robert C., Doria R. Gordon, Jennifer Juzwik, et al. "Early Intervention Strategies for Invasive Species Management: Connections Between Risk Assessment, Prevention Efforts, Eradication, and Other Rapid Responses." In Invasive Species in Forests and Rangelands of the United States. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-45367-1_6.

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AbstractManaging invasive species becomes increasingly difficult and expensive as populations of new pathogens, plants, insects, and other animals (i.e., pests) spread and reach high densities. Research over the past decade confirms the value of early intervention strategies intended to (1) prevent invasive species from arriving within an endangered area or (2) detect and respond quickly to new species incursions (Baker et al. 2009; Ewel et al. 1999; Holden et al. 2016; Leung et al. 2014). The goal of such biosecurity approaches is to keep or return the density of invasive species to zero so that damages from those pests might be prevented or to confine populations to localized areas so that damage from those species might be limited (Magarey et al. 2009). Prediction, prevention, early detection, eradication, and other rapid responses, all components of proactive management, are less costly and more effective than reactive tactics (Epanchin-Niell and Liebhold 2015; Leung et al. 2002; Lodge et al. 2006; Rout et al. 2014) (Fig. 6.1). Prediction is achieved through risk assessment (a process to forecast the likelihood and consequence of an invasion) and pathway analysis (a process to evaluate the means by which invasive species might be brought into an area of concern). Prevention is achieved through a variety of measures including regulations and quarantine treatments. Indeed, pathway analyses and subsequent regulation of those pathways are considered “the frontline in the prevention of biological invasions” (Hulme 2009) and cost-effective approaches (Essl et al. 2015; Keller et al. 2007; Leung et al. 2002; Tidbury et al. 2016). Surveillance is fundamental to early detection, and if a target species is detected, the primary rapid responses are eradication, containment, or suppression (reviewed in Beric and MacIsaac 2015). Early intervention strategies often operate at spatial scales that are much greater than the scale at which most land managers operate. Success thus requires effective coordination among researchers, regulators, and managers at international, national, sub-national, and local levels.
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Dilley, Richard A., Gisela G. Chiang, and William A. Beard. "Ca++ Gating of Proton Fluxes in Thylakoid Membranes: Regulation of Localised and Delocalised Energy Coupled Proton Gradients." In Photosynthesis. Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-642-74221-7_16.

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Barnett, Phil, Malou van den Boogaard, and Vincent Christoffels. "Localized and Temporal Gene Regulation in Heart Development." In Current Topics in Developmental Biology. Elsevier, 2012. http://dx.doi.org/10.1016/b978-0-12-387786-4.00004-x.

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De Vol, D., J. Novakofski, P. Bechtel, and P. Rotwein. "MODULATION OF INSULIN-LIKE GROWTH FACTOR I AND II mRNA DURING LOCALIZED GROWTH OF RAT SKELETAL MUSCLE AND BROWN ADIPOSE TISSUE." In Biotechnology in Growth Regulation. Elsevier, 1989. http://dx.doi.org/10.1016/b978-0-407-01473-2.50052-7.

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Erçetin, Şefika Şule, Nihan Potas, Şuay Nilhan Açıkalın, Nedim Özdemir, and Abdullah Mesut Doğan. "Municipalities and Refugee Crisis." In Immigration and the Current Social, Political, and Economic Climate. IGI Global, 2019. http://dx.doi.org/10.4018/978-1-5225-6918-3.ch036.

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Truly, while some countries are still grappling with policy issues to do with acceptance of the refugees in their respective countries, Turkey has become a safe haven to many, a refugee. This has not only featured the ordinary aspects of food, shelter, drinking water, clothing but also services like education, health, social services and transport assistance. Even more crucially, Turkey has offered other aspects bordering on integration, rights and freedoms, representation, mainstreaming and identity which are critical to the asylum seekers. This makes them feel at home especially given that they may end up staying for a long time or even never return to their homes. Such a process requires multi-dimensional legal and administrative regulation but Turkey has always come up with its own localized version of legal settings to accommodate spontaneous issues. This is what has distinguished Turkey from all other countries in the world given its immeasurable, priceless and invaluable handling of asylum seekers.
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Erçetin, Şefika Şule, Nihan Potas, Şuay Nilhan Açıkalın, Nedim Özdemir, and Abdullah Mesut Doğan. "Municipalities and Refugee Crisis." In Social Considerations of Migration Movements and Immigration Policies. IGI Global, 2018. http://dx.doi.org/10.4018/978-1-5225-3322-1.ch003.

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Truly, while some countries are still grappling with policy issues to do with acceptance of the refugees in their respective countries, Turkey has become a safe haven to many, a refugee. This has not only featured the ordinary aspects of food, shelter, drinking water, clothing but also services like education, health, social services and transport assistance. Even more crucially, Turkey has offered other aspects bordering on integration, rights and freedoms, representation, mainstreaming and identity which are critical to the asylum seekers. This makes them feel at home especially given that they may end up staying for a long time or even never return to their homes. Such a process requires multi-dimensional legal and administrative regulation but Turkey has always come up with its own localized version of legal settings to accommodate spontaneous issues. This is what has distinguished Turkey from all other countries in the world given its immeasurable, priceless and invaluable handling of asylum seekers.
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Hart, Andrew. "Pathophysiology." In Oxford Textbook of Plastic and Reconstructive Surgery. Oxford University Press, 2021. http://dx.doi.org/10.1093/med/9780199682874.003.0044.

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Compression neuropathy is the commonest form of peripheral nerve injury and refers to the symptoms and clinicopathological findings that arise when a peripheral nerve is subjected to acute or chronic external compression or impingement of sufficient magnitude to impair its microcirculation. As aerobic glycolysis fails, membrane potential regulation is impaired, and action potential transmission fails. The differential susceptibility of the various fibre types, which subserve different functions, results in a typical progression of symptoms from impaired fine touch and proprioception, through paraesthesia, to poorly localized pain. If compression persists, then secondary intraneural and vascular anatomical changes establish a downward spiral of worsening intraneural oedema and fibrosis, axonotmesis, and denervation atrophy of target muscles. The condition becomes refractory to decompression. The impact on the patient depends upon the severity of neuropathy, and the nerve affected. A small number of anatomical sites particularly predispose to compression (e.g. the carpal tunnel), resulting in the common clinical syndromes.
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Quirico, Ottavio. "Nested BoxesTangible Cultural Heritage and Environmental Protection in Light of Climate Change." In Intersections in International Cultural Heritage Law. Oxford University Press, 2020. http://dx.doi.org/10.1093/oso/9780198846291.003.0012.

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The international protection of tangible cultural heritage overlaps with that of the environment, ranging from the conservation of biodiversity to the prevention of desertification. Against this background, the phenomenon of climate change raises questions that challenge the fundamentals of the World Heritage Convention, which protects cultural heritage and interlinked natural heritage. Global warming critically affects cultural sites of outstanding universal value, such as the city of Venice, and depletes mixed cultural and natural sites inscribed on the World Heritage List, such as Tassili n’Ajjer. Arguably, the World Heritage Convention is lex specialis with respect to international environmental regulation as concerns localized adaptation and mitigation measures protecting sites of outstanding universal value. By contrast, environmental regulation, notably the UNFCCC regime as reviewed in Paris in December 2015, is lex specialis as concerns general mitigation and adaptation, systemically integrating the protection of tangible cultural heritage. This argument also applies to intangible cultural heritage, including a human rights perspective. In fact, the fundamental right to culture has been invoked in international jurisdictions to protect intangible heritage, but still remains lex generalis with respect to the UNFCCC regime. As in a set of nested boxes, such an interactive pattern outlines a basic paradigm to shape the broader intersection between the regulatory regimes protecting tangible cultural heritage and the environment in international law.
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Yamaguchi, Hideki, Takashi Matsuo, Haruaki Kageyama, et al. "Neuroendocrine Regulatory Peptides (NERPs) Localize in Human Neurons and Endocrine Tissues." In BASIC/TRANSLATIONAL - Neuroendocrine Regulation of Behavior. The Endocrine Society, 2011. http://dx.doi.org/10.1210/endo-meetings.2011.part1.p16.p1-363.

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Whitehead, Mark, Rhys Jones, and Martin Jones. "Exploring Post-National Natures: Nature in the Shadow of the State." In The Nature of the State. Oxford University Press, 2007. http://dx.doi.org/10.1093/oso/9780199271894.003.0014.

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From the beginning of this book we have consistently emphasized that our multi-faceted understanding of states cannot be simplistically equated with a nationally scaled and territorially bound institution. Despite this stated aim, in many of the preceding chapters we have described a series of ways in which state natures have been produced at a national level. Whether it has been through water supply networks, national mapping and land-use surveys, nationalized pollution monitoring networks, or nationwide judicial frameworks, we have described how nature has been framed at a distinctly national scale. While exploring the national framing of nature we have seen how the national centralization of ecological knowledge and the territorial framing of the natural world have transformed the social experience, understanding, and ability to transform nature. A closer inspection of our descriptions of the nationalization of nature within the modern state, however, revels that the process of nationalization is never quite as national as it may seem. Attempts to produce a national picture or vision of nature are always based upon more localized practices and conventions than may be immediately apparent. It is our contention that attempts to manage and regulate nature through the multifarious processes of nationalization are best conceived of as the unfulfilled desire of numerous state regimes. This statement has two implications. First, it indicates that nationally based strategies for the control and regulation of nature are only one among a series of scales in and through which states can potentially manage nature. Secondly, it suggests that states could develop other (non-national) territorial strategies in their evolving historical relationships with the natural world. This final chapter is devoted to exploring these alterative sites and moments of contemporary state–nature relations. We begin by considering the rise of sustainable cities as alterative (‘post-national’) territorial strategies in and through which states are attempting to manage contemporary social relations with nature. As sub-national, decentralized territorial units, sustainable cities provide an interesting spatial and institutional perspective on contemporary manifestations of state nature. Drawing on the example of Australia’s Sustainable Cities Inquiry, we consider how states attempt to regulate nature through the control and administration of urban space.
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Conference papers on the topic "Localized regulation"

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Kekatos, Vassilis, Liang Zhang, Georgios B. Giannakis, and Ross Baldick. "Fast localized voltage regulation in single-phase distribution grids." In 2015 IEEE International Conference on Smart Grid Communications (SmartGridComm). IEEE, 2015. http://dx.doi.org/10.1109/smartgridcomm.2015.7436387.

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Macias, N. J., and P. M. Athanas. "Application of Self-Configurability for Autonomous, Highly-Localized Self-Regulation." In 2007 2nd NASA/ESA Conference on Adaptive Hardware and Systems. IEEE, 2007. http://dx.doi.org/10.1109/ahs.2007.32.

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Christen, Jennifer Blain, Andreas G. Andreou, and Brian Iglehart. "Localized closed-loop temperature control and regulation in hybrid silicon/silicone life science microsystems." In 2007 IEEE International Symposium on Circuits and Systems. IEEE, 2007. http://dx.doi.org/10.1109/iscas.2007.377852.

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You, Yeonhee, Jun Hee Hong, Jinlong Yin, Young Taek Oh, Sung Soo Kim, and Jong Bae Park. "Abstract 1133: Mitochondria localized EGFRvIII promotes stemness through regulation of mitochondrial dynamics in glioblastoma stem cells." In Proceedings: AACR Annual Meeting 2018; April 14-18, 2018; Chicago, IL. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1538-7445.am2018-1133.

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Belyakova, I. A., O. Yu Nikiforova, A. N. Baikov, O. I. Urazova, O. V. Filinyuk, and L. V. Smirnova. "Effect of superweak modulated IR radiation on vegetative regulation of heart rhythm of children with localized forms of pulmonary tuberculosis." In XXII International Symposium Atmospheric and Ocean Optics. Atmospheric Physics, edited by Gennadii G. Matvienko and Oleg A. Romanovskii. SPIE, 2016. http://dx.doi.org/10.1117/12.2249236.

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Zhou, Rongliang, Cullen Bash, Zhikui Wang, Alan McReynolds, Thomas Christian, and Tahir Cader. "Data Center Cooling Efficiency Improvement Through Localized and Optimized Cooling Resources Delivery." In ASME 2012 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/imece2012-88817.

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Data centers are large computing facilities that can house tens of thousands of computer servers, storage and networking devices. They can consume megawatts of power and, as a result, reject megawatts of heat. For more than a decade, researchers have been investigating methods to improve the efficiency by which these facilities are cooled. One of the key challenges to maintain highly efficient cooling is to provide on demand cooling resources to each server rack, which may vary with time and rack location within the larger data center. In common practice today, chilled water or refrigerant coo
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Henderson, Jonathan T., Garrett Shannon, Alexander I. Veress, and Corey P. Neu. "Newly Synthesized RNA and Intranuclear Strain Measurements in Living Cells Maintained Within Native Tissue." In ASME 2013 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/sbc2013-14202.

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The nucleus is a regulation center for cellular gene expression 1. Mechanical forces transfer to the nucleus directly and indirectly through cellular cytoskeletal structures and pathways 2, 3. The transmitted strains often cause nuclear deformation which is thought to trigger mechanosensitive gene expression within the nucleus 4. Protein dynamics inside the nucleus are additionally important for maintaining the nuclear structure and in facilitating gene expression at the transcription level 5. Probing spatiotemporal relationships between mechanical forces and localized gene expression (i.e. bi
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LOFTUS, J. C., E. F. Plow, A. L. Frelinger III, M. A. Smith, S. D’ouza, and M. H. Ginsberg. "LOCALIZATION AND CHEMICAL SYNTHESIS OF A DIVALENT CATION REGULATED EPITOPE IN PLATELET MEMBRANE GPIIb." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643959.

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Platelet membrane glycoprotein (GP)IIb-IIIa is a component of a common adhesive protein receptor for fibrinogen, fibronectin, and von Willebrand factor. A monoclonal antibody, PMI-1, defines a divalent cation dependent regulation of the surface orientation of the heavy chain of GPIIb. Exposure of the PMI-1 epitope inversely correlates with the capacity of platelets to bind fibrinogen and aggregate. We have now localized and chemically synthesized this epitope. A 1.1 Kb cDNA clone which directs the synthesis of a fusion protein which bears the PMI-1 epitope was isolated from a lambda gt 11 expr
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Fly, Ashley, and Rob H. Thring. "Model Based Investigation of Liquid Water Injection Strategies for Evaporatively Cooled PEM Fuel Cells." In ASME 2015 13th International Conference on Fuel Cell Science, Engineering and Technology collocated with the ASME 2015 Power Conference, the ASME 2015 9th International Conference on Energy Sustainability, and the ASME 2015 Nuclear Forum. American Society of Mechanical Engineers, 2015. http://dx.doi.org/10.1115/fuelcell2015-49196.

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Evaporative cooling through liquid water injection directly into the fuel cell flow channels removes the requirement for external humidification and liquid cooling channels within the stack. However, the amount of liquid water injected must be accurately controlled, to prevent on one hand membrane drying due to lack of water vapor and on the other hand flooding due to excessive liquid water. In this paper a one-dimensional, non-isothermal model of an evaporatively cooled proton exchange membrane fuel cell (PEMFC) is produced. The model accounts for changes in relative humidity and temperature
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Dutta, Sandip, and Prashant Singh. "Impingement Heat Transfer Innovations and Enhancements: a Discussion on Selected Geometrical Features." In ASME Turbo Expo 2021: Turbomachinery Technical Conference and Exposition. American Society of Mechanical Engineers, 2021. http://dx.doi.org/10.1115/gt2021-59394.

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Abstract Impingement heat transfer is considered as one of the most effective cooling technologies that yields in high localized convective heat transfer coefficient. This paper studies different configurational parameters involved in jet impingement cooling such as, exit orifice shape, crossflow regulation, target surface modification, spent air reuse, impingement channel modification, jet pulsation, and other techniques to understand what are critical and how these heat transfer enhancement concepts work. These enhancement factors have been explored in detail by many researchers, including s
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Reports on the topic "Localized regulation"

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Phillips, Jake. Understanding the impact of inspection on probation. Sheffield Hallam University, 2021. http://dx.doi.org/10.7190/shu.hkcij.05.2021.

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This research sought to understand the impact of probation inspection on probation policy, practice and practitioners. This important but neglected area of study has significant ramifications because the Her Majesty’s Inspectorate of Probation has considerable power to influence policy through its inspection regime and research activities. The study utilised a mixed methodological approach comprising observations of inspections and interviews with people who work in probation, the Inspectorate and external stakeholders. In total, 77 people were interviewed or took part in focus groups. Probati
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