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Dissertations / Theses on the topic 'Locally advanced carcinoma breast'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Gagno, Sara. "Innovative strategies for tailoring therapy in cancer patient: pharmacogenetics and hormone therapy personalization in metastatic or locally advanced breast cancer patients treated with Exemestane." Doctoral thesis, Università degli studi di Padova, 2015. http://hdl.handle.net/11577/3423964.

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Background: Response to chemotherapeutic agents is highly variable among patients both in terms of efficacy and tolerability; consequently personalization of drug therapy is one of the main objective in cancer treatment in order to reduce adverse drug reactions (ADRs), improve efficacy while decreasing the costs of treatments. Many factors account for inter-individual differences. Among them, patient’s genetic background has attracted interest for personalization of drug therapy (Pharmacogenetics). Breast cancer (BC) is the female most frequently diagnosed malignancy and the primary cause of

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2

Garieri, Alexandre Pavan. "Produção de VEGF e HIF-1? em pacientes com carcinoma de mama localmente avançado submetidas à quimioterapia neoadjuvante." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/17/17145/tde-24042012-144303/.

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Determinar o valor prognóstico e preditivo do VEGF (vascular endothelial growth factor) e do HIF-1? (Hypoxia-inducible factor-1) em relação à sobrevida livre de doença (SLD) e sobrevida global (SG) em pacientes com carcinoma de mama localmente avançado (CMLA) tratadas primariamente pela quimioterapia neoadjuvante. MATERIAIS E METODOS: VEGF e HIF foram quantificados consecutivamente em plasma de 36 pacientes com CMLA pelo método de ELISA (enzyme labeling immunoassay absorbant) para o VEGF165 e o HIF-1?. O tratamento neoadjuvante foi realizado em todas as pacientes com docetaxel e epirrubicina.

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3

Atalay, Mustafa Can. "Multidrug Resistance In Locally Advanced Breast Cancer." Phd thesis, METU, 2004. http://etd.lib.metu.edu.tr/upload/12604991/index.pdf.

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ABSTRACT MULTIDRUG RESISTANCE IN LOCALLY ADVANCED BREAST CANCER ATALAY, Mustafa Can Ph. D., Department of Biotechnology Supervisor: Prof. Dr. Ufuk G&Uuml<br>ND&Uuml<br>Z June 2004, 70 pages Breast cancer is the most frequently detected cancer among women. Early diagnosis leads to long term survival when the patients are treated with surgery, radiotherapy, chemotherapy, and hormone therapy. Unfortunately, advanced disease could still be encountered in some patients resulting in a poorer prognosis. The primary treatment modality is chemotherapy for this group of patients. Drug resista

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4

Cao, Maria Dung. "MR metabolic characterization of locally advanced breast cancer : – treatment effects and prognosis." Doctoral thesis, Norges teknisk-naturvitenskapelige universitet, Institutt for sirkulasjon og bildediagnostikk, 2012. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-16250.

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Brystkreft er den hyppigste kreftsykdommen blant kvinner. Lokalavansert brystkreft utgjør omtrent 10% av alle brystkrefttilfeller og omfatter en heterogen pasientgruppe med ulike prognoser. Pasienter med lokalavansert brystkreft får ofte kjemoterapi før kirurgisk fjerning av tumor, såkalt neoadjuvant kjemoterapi, for å redusere størrelsen på tumoren. Det er stor variasjon i behandlingsrespons for denne pasientgruppen, og det er derfor behov for å utvikle målrettet og individualisert behandling, samt metoder for oppfølging av behandlingsrespons. Metabolomics er en systematisk analyse av småmole

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5

Silveira, Willian Abraham da. "Genetic profile analysis of tumor stem cells in locally advanced breast cancer." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/17/17145/tde-05012016-144854/.

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INTRODUCTION: Breast cancer is the most common cancer in women worldwide and metastatic dissemination is the principal factor related to death by this disease. Breast cancer stem cells (bCSC), defined in this work as the ALDH1high/LIN-/ESA+ population, are thought to be responsible for metastasis and chemoresistance. The objective of this work is to find gene master regulators, in particular transcription factors (TFs), which are controlling the bCSC phenotype. METHODS: We used in this work two groups of datasets with transcriptome data, the discovery dataset group contains one dataset obtaine

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6

NAGANAWA, SHINJI, MASATAKA SAWAKI, AKIKO NISHIO, SATOKO ISHIGAKI, HIROKO SATAKE, and MARIKO KAWAMURA. "EARLY PREDICTION OF RESPONSE TO NEOADJUVANT CHEMOTHERAPY FOR LOCALLY ADVANCED BREAST CANCER USING MRI." Nagoya University School of Medicine, 2011. http://hdl.handle.net/2237/15357.

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7

Aguiar, Marco AntÃnio Nasser. "Expression of nuclear factor Kappa B (NF-KB) and Interleukin-18 (IL-18) in inflammatory breast cancer and locally advanced breast cancer." Universidade Federal do CearÃ, 2015. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=15328.

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CoordenaÃÃo de AperfeÃoamento de Pessoal de NÃvel Superior<br>Inflammatory Breast Cancer (IBC) is the most aggressive form of locally advanced breast cancer. It is more common in young women and unfavorably, in most of the times, evolves quickly. Presents with typical signs of inflammation such as hyperemia and hyperthermia its pathogenesis and evolution has been associated with possible participation of inflammatory mediators such as cytokines (TNF-α e IL-1β), enzymes (cyclooxygenase-2 [COX-2] and nitric oxide synthase [iNOS]), as well as, transcription factors (Nuclear Factor kappa

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8

Hristozova, Tsvetana [Verfasser]. "Characterization of circulating tumor cells in locally advanced squamous cell carcinoma of the head and neck / Tsvetana Hristozova." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2012. http://d-nb.info/1030380716/34.

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9

Van, Niekerk Wayne. "Late radiation proctitis : the incidence and contributing factors in patients with locally advanced cervical carcinoma treated at Pretoria Academic Hospital." Master's thesis, University of Cape Town, 2003. http://hdl.handle.net/11427/11000.

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Includes bibliographical references.<br>The purpose of the thesis is to determine the incidence of late radiation proctitis in patients treated with radical radiotherapy in Pretoria Academic Hospital during a peroid when hypofractionated radiotherapy and external boosts were being utilised for the treatment of advances carcinoma of the cervix. Possible contributing factors were also examined in an attempt to identify areas where possible changes to our treatment policies would ensure effective palliation without severe late radiation proctitis.

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10

Hamy, Anne-Sophie. "Identification of Factors Predicting Sensitivity or Resistance to Neoadjuvant Chemotherapy in Breast Cancer Neoadjuvant treatment : the future of patients with breast cancer Neoadjuvant treatment for intermediate/high-risk HER2-positive and triple-negative breast cancers: no longer an “option” but an ethical obligation Long-term outcome of the REMAGUS 02 trial, a multicenter randomised phase II trial in locally advanced breast cancer patients treated with neoadjuvant chemotherapy with or without celecoxib or trastuzumab according to HER2 status BIRC5 (survivin) : a pejorative prognostic marker in stage II/III breast cancer with no response to neoadjuvant chemotherapy Beyond Axillary Lymph Node Metastasis, BMI and Menopausal Status Are Prognostic Determinants for Triple-Negative Breast Cancer Treated by Neoadjuvant Chemotherapy Pathological complete response and prognosis after neoadjuvant chemotherapy for HER2-positive breast cancers before and after trastuzumab era: results from a real-life cohort The presence of an in situ component on pre-treatment biopsy is not associated with response to neoadjuvant chemotherapy for breast cancer Chemosensitivity, tumor infiltrating lymphocytes (TILs), and survival of postpartum PABC patients treated by neoadjuvant chemotherapy Lymphovascular invasion after neoadjuvant chemotherapy is strongly associated with poor prognosis in breast carcinoma New insight for pharmacogenomics studies from the transcriptional analysis of two large-scale cancer cell line panels Biological network-driven gene selection identifies a stromal immune module as a key determinant of triple-negative breast carcinoma prognosis A Stromal Immune Module Correlated with the Response to Neoadjuvant Chemotherapy, Prognosis and Lymphocyte Infiltration in HER2-Positive Breast Carcinoma Is Inversely Correlated with Hormonal Pathways Stromal lymphocyte infiltration after neoadjuvant chemotherapy is associated with aggressive residual disease and lower disease-free survival in HER2-positive breast cancer Interaction between molecular subtypes, stromal immune infiltration before and after treatment in breast cancer patients treated with neoadjuvant chemotherapy COX2/PTGS2 Expression Is Predictive of Response to Neoadjuvant Celecoxib in HER2-negative Breast Cancer Patients Celecoxib With Neoadjuvant Chemotherapy for Breast Cancer Might Worsen Outcomes Differentially by COX-2 Expression and ER Status: Exploratory Analysis of the REMAGUS02 Trial Comedications influence immune infiltration and pathological response to neoadjuvant chemotherapy in breast cancer." Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLS129.

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La chimiothérapie néoadjuvante (CNA) est utilisée dans les cancers du sein agressifs ou localement avancés (CS). Au delà des bénéfices cliniques, elle représente une opportunité pour monitorer in vivo la sensibilité d’une tumeur à un traitement.A partir de l’analyse de sets de données de patients traités par CNA, nous souhaitons identifier des mécanismes associes à la résistance ou sensibilité au traitement. Dans la première partie, nous avons évalué des paramètres, cliniques, anatomopathologiques et transcriptomiques. Nous avons démontré que des éléments non explorés comme la présence d’embol

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11

McDermott, Garry M. "Predicting the response of large and locally advanced breast cancers to neoadjuvant chemotherapy using 2-Deoxy-2-[18F]-Fluoro-D-Glucose positron emission tomography." Thesis, University of Aberdeen, 2006. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU225321.

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Introduction: The purpose of this thesis was to compare 2-deoxy-2-[18F]-fluoro-D-glucose positron emission tomography (FDG-PET) images of large and locally advanced breast cancers, which were acquired during Anthracycline-based neoadjuvant chemotherapy. The aim was to determine the effectiveness of FDG-PET for predicting the pathological response of tumours. Method: PET images were acquired before the first and second cycles, at the midpoint and at the endpoint of neoadjuvant chemotherapy. The tumour images were quantified using a range of methods including: volume delineations, standardised u

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12

Chilwesa, Paul Mambwe. "Comparison of 18F-Fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (18F-FDG PET/CT) and conventional imaging (CI) for locally advanced breast cancer staging: a prospective study from a tertiary hospital cancer centre in Western Cape." Master's thesis, Faculty of Health Sciences, 2019. http://hdl.handle.net/11427/31433.

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Background: Breast cancer is the second most common cancer in adults and the most frequent cancer diagnosed in women. In South Africa, breast cancer accounts for 38.5% of cancers diagnosed in women. Since the presence, extent and location of distant metastases is one important prognostic factor in locally advanced breast cancer (LABC), accurate staging at diagnosis is crucial to ensure patients receive the appropriate treatment. Increasing evidence shows that the use of 18F-FDG PET/CT for disease staging of LABC may improve diagnostic sensitivity. Aim: To prospectively assess the difference

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13

Schmidt, Stefan [Verfasser], Steffen [Gutachter] Löck, and Jan [Gutachter] Alsner. "Predicting patient-specific outcome based on machine learning algorithms using genomic data of patients with locally advanced head and neck squamous cell carcinoma / Stefan Schmidt ; Gutachter: Steffen Löck, Jan Alsner." Dresden : Sächsische Landesbibliothek – Staats- und Universitätsbibliothek Dresden, 2019. http://d-nb.info/1227196768/34.

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14

Ostheimer, Christian Emil Arthur Verfasser], Dirk [Akademischer Betreuer] Vordermark, Bernd [Akademischer Betreuer] Schmidt, and Daniel [Akademischer Betreuer] [Zips. "Prognostic and predictive significance of osteopontin and other hypoxia-related plasma proteins in the radiotherapy of locally advanced and metastatic bronchial carcinoma / Christian Emil Arthur Ostheimer. Betreuer: Dirk Vordermark ; Bernd Schmidt ; Daniel Zips." Halle, Saale : Universitäts- und Landesbibliothek Sachsen-Anhalt, 2015. http://d-nb.info/1089085419/34.

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15

Ahmad, Khalil Dalia Abdel-Moaty [Verfasser]. "Accelerated Intensity Modulated Radiotherapy using Simultaneous Integrated Boost (SIB-IMRT) versus Intensity Modulated Hyperfractionated Accelerated Radiotherapy using Sequential Field (HART-SEQ-IMRT) for primary treatment in patients with locally advanced head and neck Squamous Cell Carcinoma / Dalia Abdel-Moaty Ahmad Khalil." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2012. http://d-nb.info/1027275826/34.

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16

Kaewkangsadan, Viriya. "Evaluation of immune cell infiltrates and expression of cytokines/biological molecules in the microenvironment of tumours and tumour-draining axillary lymph nodes in patients with large and locally advanced breast cancers undergoing neoadjuvant chemotherapy : crucial contribution to immune-mediated tumour cell death." Thesis, University of Nottingham, 2016. http://eprints.nottingham.ac.uk/34155/.

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Background: Neoadjuvant chemotherapy (NAC) is being used as first line treatment in women with large and locally advanced breast cancers (LLABCs). However, the response to NAC is difficult to predict. Growing evidence suggests that these patients are immunosuppressed and that circulating immunosuppressive regulatory cells and humoral factors affect the response to NAC. We explored the possible role of the in situ tumour immune milieu in inducing and affecting the responses to NAC, and the contribution of concomitant systemic circulating regulatory cells. Methods: Paraffin-embedded breast cance

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17

Seisen, Thomas. "Caractérisation de l’évolution des tumeurs urothéliales de la voie excrétrice urinaire supérieure après néphrourétérectomie totale A Systematic Review and Meta-analysis of Clinicopathologic Factors Linked to Intravesical Recurrence After Radical Nephroureterectomy to Treat Upper Tract Urothelial Carcinoma Effectiveness of Adjuvant Chemotherapy After Radical Nephroureterectomy for Locally Advanced and/or Positive Regional Lymph Node Upper Tract Urothelial Carcinoma." Thesis, Sorbonne université, 2018. http://www.theses.fr/2018SORUS486.

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Même si la néphrourétérectomie totale représente le traitement de référence des tumeurs de la voie excrétrice urinaire supérieure (TVEUS), il existe un risque élevé de récidive post-opératoire qui peut survenir soit au niveau de la vessie soit dans la loge de résection et/ou sur le plan systémique. L’objectif de ce travail était de caractériser ces différents modes évolutifs. En ce qui concerne la récidive intra-vésicale, une revue systématique de la littérature avec méta-analyse a permis d’identifier les principaux facteurs de risque à la fois cliniques et anatomopathologiques. Par ailleurs,

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18

CHAN, SI-WA, and 陳詩華. "Dynamic contrast enhanced MRI in monitoring early response of locally advanced breast cancer undergoing neoadjuvant chemotherapy." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/50331488860547793179.

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碩士<br>逢甲大學<br>生醫資訊暨生醫工程碩士學位學程<br>98<br>Patients who present with late stage disease, which is frequently locally advanced (LABC), will be treated initially with neoadjuvant chemotherapy to down-stage the disease, followed by surgery and post-operative therapies. Monitoring a patient’s response to neoadjuvant chemotherapy is usually undertaken by clinical examination, mammography and ultrasound. Unfortunately, there is a poor correlation between the histological appearances of the tumor and measurements obtained by physical examination, mammography or ultrasound. Techniques for magnetic resonan

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19

Romano, Carmela. "Gefitinib and Radiotherapy in patients with locally advanced inoperable squamous cell carcinoma of the head and neck." Tesi di dottorato, 2008. http://www.fedoa.unina.it/3051/1/TESI-DOTTORATO_CARMELA-ROMANO-XIX-ciclo.pdf.

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Introduction: Gefitinib, an orally active epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, induces growth arrest in squamous cancer cell carcinoma of head and neck (SCCHN) cell lines mainly by blocking cells in G1 and preventing them from entering the cell cycle. Clinical studies have demonstrated the activity of gefitinib monotherapy in SCCHN. Preclinical studies have shown that the combination of radiotherapy (RT) and drugs interfering with the EGF pathway may result in radiosensitization in squamous cell carcinomas that over express EGFR. Purpose: Two different doses of g

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20

Schmidt, Stefan. "Predicting patient-specific outcome based on machine learning algorithms using genomic data of patients with locally advanced head and neck squamous cell carcinoma." 2019. https://tud.qucosa.de/id/qucosa%3A36498.

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Aufgrund der heterogenen Tumorbiologie variiert der Therapieerfolg bei lokal fortgeschrittenen Plattenepithelkarzinomen stark, woraus ein mittleres 5-Jahres-Überleben dieser Patienten von etwa 50% resultiert. Um die Therapie besser an die Tumoreigenschaften anzupassen, muss die Therapieresistenz der Tumoren vor der Behandlung bestimmt werden. In dieser Dissertationsschrift werden Methoden aus dem Bereich des maschinellen Lernens angewandt um Genexpressionsdaten zu analysieren, um so Signaturen und Modelle zu erzeugen die eine Klassifizierung der Tumoren in verschiedene Risikogruppen bezüglich

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21

Yeh, Ying-Chih, and 葉盈池. "Effectiveness and Cost-Effectiveness of Trastuzumab Emtansine in Women with HER2-Positive Locally Advanced or Metastatic Breast Cancer: A Systematic Review and Meta-Analysis." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/c8et72.

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