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Dissertations / Theses on the topic 'Locally advanced cervical cancer'

Author: Grafiati

Published: 29 March 2025

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1

Bhagaloo, Visham. "Volumetric modulated Arc Therapy versus 3D conformal radiotherapy in the treatment of locally advanced cervical cancer. A single institution, comparative dosimetric study." Master's thesis, Faculty of Health Sciences, 2021. http://hdl.handle.net/11427/32601.

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Background: External Beam Radiotherapy is essential in the management of locally advanced cervical cancer (LACC). Generally, VMAT is thought to achieve higher conformity to the Planned Target Volume (PTV) and better sparing of organs at risk (OAR) when compared to 3D-CRT. This study focused on these principles as it applied to treatment and potential toxicity in the management of LACC. Aim: To compare dosimetric parameters between VMAT and 3D-CRT in the management of LACC. Setting: The study analysed patients treated at Groote Schuur Hospital between May and December 2017. Method: A non-random

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Atalay, Mustafa Can. "Multidrug Resistance In Locally Advanced Breast Cancer." Phd thesis, METU, 2004. http://etd.lib.metu.edu.tr/upload/12604991/index.pdf.

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ABSTRACT MULTIDRUG RESISTANCE IN LOCALLY ADVANCED BREAST CANCER ATALAY, Mustafa Can Ph. D., Department of Biotechnology Supervisor: Prof. Dr. Ufuk G&Uuml<br>ND&Uuml<br>Z June 2004, 70 pages Breast cancer is the most frequently detected cancer among women. Early diagnosis leads to long term survival when the patients are treated with surgery, radiotherapy, chemotherapy, and hormone therapy. Unfortunately, advanced disease could still be encountered in some patients resulting in a poorer prognosis. The primary treatment modality is chemotherapy for this group of patients. Drug resista

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Vermaas, Maarten. "Multimodality treatment for locally advanced and recurrent rectal cancer." [S.l.] : Rotterdam : [The Author] ; Erasmus University [Host], 2008. http://hdl.handle.net/1765/11997.

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Arcelli, Alessandra <1983&gt. "Outcome analysis of predictors in locally advanced pancreatic cancer." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2021. http://amsdottorato.unibo.it/9565/3/arcelli_alessandra_tesi.pdf.

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Guidelines report a wide range of options in locally advanced pancreatic cancer (LAPC): definitive chemotherapy or chemoradiotherapy or the emerging stereotactic body radiotherapy (SBRT) (+/- chemotherapy). On behalf of the AIRO (Italian Association of Radiation Oncology and Clinical Oncology) Gastrointestinal Study Group, we collected retrospective clinical data on 419 LAPC from 15 Italian centers. The study protocol (PAULA-1: Pooled Analysis in Unresectable Locally Advanced pancreatic cancer) was approved by institutional review board of S. Orsola-Malpighi Hospital (201/2015/O/OssN). From th

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Hakenberg, Oliver W., Michael Fröhner, and Manfred P. Wirth. "Treatment of Locally Advanced Prostate Cancer – The Case for Radical Prostatectomy." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-133798.

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The treatment of clinically locally advanced prostate carcinoma (stage cT3) remains controversial. One of the main reasons for this controversy results from the substantial staging error attached to the clinical diagnosis cT3 with overstaged T2 tumors and understaged node-positive cases. Treatment options in this situation include radical prostatectomy, external beam radiotherapy, immediate or delayed androgen deprivation treatment and the so-called ‘watchful waiting’. Acceptable and often surprisingly good tumor-specific survival rates have been reported for radical prostatectomy in pT3 serie

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Hakenberg, Oliver W., Michael Fröhner, and Manfred P. Wirth. "Treatment of Locally Advanced Prostate Cancer – The Case for Radical Prostatectomy." Karger, 2006. https://tud.qucosa.de/id/qucosa%3A27536.

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The treatment of clinically locally advanced prostate carcinoma (stage cT3) remains controversial. One of the main reasons for this controversy results from the substantial staging error attached to the clinical diagnosis cT3 with overstaged T2 tumors and understaged node-positive cases. Treatment options in this situation include radical prostatectomy, external beam radiotherapy, immediate or delayed androgen deprivation treatment and the so-called ‘watchful waiting’. Acceptable and often surprisingly good tumor-specific survival rates have been reported for radical prostatectomy in pT3 serie

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7

Cao, Maria Dung. "MR metabolic characterization of locally advanced breast cancer : – treatment effects and prognosis." Doctoral thesis, Norges teknisk-naturvitenskapelige universitet, Institutt for sirkulasjon og bildediagnostikk, 2012. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-16250.

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Brystkreft er den hyppigste kreftsykdommen blant kvinner. Lokalavansert brystkreft utgjør omtrent 10% av alle brystkrefttilfeller og omfatter en heterogen pasientgruppe med ulike prognoser. Pasienter med lokalavansert brystkreft får ofte kjemoterapi før kirurgisk fjerning av tumor, såkalt neoadjuvant kjemoterapi, for å redusere størrelsen på tumoren. Det er stor variasjon i behandlingsrespons for denne pasientgruppen, og det er derfor behov for å utvikle målrettet og individualisert behandling, samt metoder for oppfølging av behandlingsrespons. Metabolomics er en systematisk analyse av småmole

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Silveira, Willian Abraham da. "Genetic profile analysis of tumor stem cells in locally advanced breast cancer." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/17/17145/tde-05012016-144854/.

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INTRODUCTION: Breast cancer is the most common cancer in women worldwide and metastatic dissemination is the principal factor related to death by this disease. Breast cancer stem cells (bCSC), defined in this work as the ALDH1high/LIN-/ESA+ population, are thought to be responsible for metastasis and chemoresistance. The objective of this work is to find gene master regulators, in particular transcription factors (TFs), which are controlling the bCSC phenotype. METHODS: We used in this work two groups of datasets with transcriptome data, the discovery dataset group contains one dataset obtaine

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9

Winter, Jane. "Living with locally advanced rectal cancer : an exploration of the everydayness of living with rectal cancer." Thesis, University of Southampton, 2010. https://eprints.soton.ac.uk/72288/.

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Advances in treatment and prolonged survival times mean that increasingly individuals are living with advanced cancer, yet services remain disease orientated. This thesis has documented the process of undertaking a longitudinal qualitative study to explore the everydayness of living with locally advanced rectal cancer. The study has identified how this can influence individual’s day to day lives when the focus of care moves away from cure, but prior to the transition to ‘end of life’ care. The aim was to obtain data in which to situate local service development based on those aspects which wer

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10

Nguyen, Nam, Siyoung Jang, Jacqueline Vock, et al. "Feasibility of intensity-modulated and image-guided radiotherapy for locally advanced esophageal cancer." BioMed Central, 2014. http://hdl.handle.net/10150/610350.

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BACKGROUND:In this study the feasibility of intensity-modulated radiotherapy (IMRT) and tomotherapy-based image-guided radiotherapy (IGRT) for locally advanced esophageal cancer was assessed.METHODS:A retrospective study of ten patients with locally advanced esophageal cancer who underwent concurrent chemotherapy with IMRT (1) and IGRT (9) was conducted. The gross tumor volume was treated to a median dose of 70Gy (62.4-75Gy).RESULTS:At a median follow-up of 14months (1-39 months), three patients developed local failures, six patients developed distant metastases, and complications occurred in

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Bhangu, Aneel. "Epithelial mesenchymal transition and resistance to neoadjuvant radiotherapy in locally advanced rectal cancer." Thesis, Imperial College London, 2014. http://hdl.handle.net/10044/1/24734.

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Background: Non-response to neoadjuvant therapy is a significant challenge for clinicians managing solid cancers. This thesis aimed to determine whether Epithelial Mesenchymal Transition (EMT) was associated with non-response to neoadjuvant therapy in patients with locally advanced rectal cancer. Methods: Representative tissue specimens from the tumour invasive front of consecutive patients undergoing resection of rectal cancer from 2009-2011 were used. Patients with marked regression to neoadjuvant therapy were classified as responders with the remainder as non-responders. Markers of EMT incl

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12

Veaco, Jennifer Mitchell. "Prospective Detection of Chemoradiation Resistance in Patients with Locally Advanced Esophageal Adenocarcinoma." Thesis, The University of Arizona, 2017. http://hdl.handle.net/10150/623577.

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A Thesis submitted to The University of Arizona College of Medicine - Phoenix in partial fulfillment of the requirements for the Degree of Doctor of Medicine.<br>Approximately 25% of patients with locoregional esophageal adenocarcinoma (EC) are resistant (marked by minimal tumor regression; TRG 3) to preoperative chemoradiation, including 5FU‐based and CROSS regimens. Previously, an immunohistochemistry (IHC) test that accurately identifies patients as responders (TRG 0‐2) or non‐responders (TRG 3) to neoadjuvant CTRT was developed and validated. The current study was designed to identify gene

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NAGANAWA, SHINJI, MASATAKA SAWAKI, AKIKO NISHIO, SATOKO ISHIGAKI, HIROKO SATAKE, and MARIKO KAWAMURA. "EARLY PREDICTION OF RESPONSE TO NEOADJUVANT CHEMOTHERAPY FOR LOCALLY ADVANCED BREAST CANCER USING MRI." Nagoya University School of Medicine, 2011. http://hdl.handle.net/2237/15357.

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Robinson, David. "Prediction of survival in prostate cancer : aspects on localised, locally advanced and metastatic disease." Doctoral thesis, Linköping : Department of Clinical and Experimental Medicine, Linköping University, 2008. http://www.bibl.liu.se/liupubl/disp/disp2008/med1073s.pdf.

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15

Van, Niekerk Wayne. "Late radiation proctitis : the incidence and contributing factors in patients with locally advanced cervical carcinoma treated at Pretoria Academic Hospital." Master's thesis, University of Cape Town, 2003. http://hdl.handle.net/11427/11000.

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Includes bibliographical references.<br>The purpose of the thesis is to determine the incidence of late radiation proctitis in patients treated with radical radiotherapy in Pretoria Academic Hospital during a peroid when hypofractionated radiotherapy and external boosts were being utilised for the treatment of advances carcinoma of the cervix. Possible contributing factors were also examined in an attempt to identify areas where possible changes to our treatment policies would ensure effective palliation without severe late radiation proctitis.

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Nguyen, Nam, Jacqueline Vock, Vincent Vinh-Hung, et al. "Effectiveness of prophylactic retropharyngeal lymph node irradiation in patients with locally advanced head and neck cancer." BioMed Central, 2012. http://hdl.handle.net/10150/610347.

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BACKGROUND:The aim of the study is to assess the effectiveness of intensity-modulated radiotherapy (IMRT) or image-guided radiotherapy (IGRT) for the prevention of retropharyngeal nodal recurrences in locally advanced head and neck cancer.METHODS:A retrospective review of 76 patients with head and neck cancer undergoing concurrent chemoradiation or postoperative radiotherapy with IMRT or IGRT who were at risk for retropharyngeal nodal recurrences because of anatomic site (hypopharynx, nasopharynx, oropharynx) and/or the presence of nodal metastases was undertaken.The prevalence of retropharyng

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Cleary, James M., Harvey J. Mamon, Jackie Szymonifka, et al. "Neoadjuvant irinotecan, cisplatin, and concurrent radiation therapy with celecoxib for patients with locally advanced esophageal cancer." BioMed Central, 2016. http://hdl.handle.net/10150/618723.

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Background: Patients with locally advanced esophageal cancer who are treated with trimodality therapy have a high recurrence rate. Preclinical evidence suggests that inhibition of cyclooxygenase 2 (COX2) increases the effectiveness of chemoradiation, and observational studies in humans suggest that COX-2 inhibition may reduce esophageal cancer risk. This trial tested the safety and efficacy of combining a COX2 inhibitor, celecoxib, with neoadjuvant irinotecan/cisplatin chemoradiation. Methods: This single arm phase 2 trial combined irinotecan, cisplatin, and celecoxib with concurrent radiation

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18

Hotton, Judicaël. "Impact de la TEP/TDM au 18F-FDG et de la radiomique dans la prise en charge des cancers du col localement avancés." Electronic Thesis or Diss., Reims, 2024. http://www.theses.fr/2024REIMM202.

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Le cancer du col de l'utérus, bien que rare, est une maladie grave touchant souvent des femmes jeunes, avec environ 3 000 nouveaux cas par an en France. La survie dépend du stade de la maladie au diagnostic : les formes avancées nécessitent une radiochimiothérapie concomitante, et l'atteinte ganglionnaire lombo-aortique est un facteur pronostique essentiel. Traditionnellement, la stadification chirurgicale était utilisée pour évaluer cette atteinte, mais la TEP/TDM au 18F-FDG est aujourd’hui préférée, bien qu’elle soit limitée dans la détection de métastases de petite taille.Notre travail expl

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Bhim, Nazreen. "Dysphagia progression-free survival in patients with locally advanced and metastatic oesophageal cancer receiving palliative radiation therapy." Master's thesis, Faculty of Health Sciences, 2021. http://hdl.handle.net/11427/32591.

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Purpose: In patients with advanced oesophageal carcinoma palliation of dysphagia is important to maintaining a reasonable quality of life. The primary aim of this study was to determine the dysphagia progression-free survival (DPFS) in patients with advanced oesophageal carcinoma treated with palliative radiotherapy (RT). Methods: The medical records of all patients with oesophageal carcinoma presenting to Groote Schuur Hospital, Cape Town between January 2015-December 2016 were reviewed and patients who were not candidates for curative treatment and received palliative RT were selected. For t

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Radu, Calin. "Optimising Radiotherapy in Rectal Cancer Patients." Doctoral thesis, Uppsala universitet, Enheten för onkologi, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-172531.

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Rectal cancer is the eight most common cancer diagnosis in Sweden in both men and women, with almost 2000 new cases per year. Radiotherapy, which is an important treatment modality for rectal cancer, has evolved during the past decades. Diagnostic tools have also improved, allowing better staging and offering information used to make well-founded decisions in multidisciplinary team conferences. In a retrospective study (n=46) with locally advanced rectal cancer (LARC) patients, unfit for chemoradiotherapy, patients were treated with short-course radiotherapy. Delayed surgery was done when poss

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Seamon, Leigh G., James J. Java, Bradley J. Monk, et al. "Impact of tumour histology on survival in advanced cervical carcinoma: an NRG Oncology/Gynaecologic Oncology Group Study." NATURE PUBLISHING GROUP, 2017. http://hdl.handle.net/10150/626543.

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Background: Based primarily on studies concerning early-stage tumours (treated surgically), and locally advanced disease (treated with chemoradiation), the prognosis for women with adenocarcinoma (AC) or adenosquamous (AS) carcinoma has been reported to be poorer than those with squamous cell carcinoma (SCCA) of the cervix. It is unclear whether differences in prognosis also persist in the setting of recurrent or metastatic disease treated using chemotherapy doublets with or without bevacizumab. Methods: Cases were pooled from three Gynaecologic Oncology Group randomised phase III trials of ch

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Aguiar, Marco AntÃnio Nasser. "Expression of nuclear factor Kappa B (NF-KB) and Interleukin-18 (IL-18) in inflammatory breast cancer and locally advanced breast cancer." Universidade Federal do CearÃ, 2015. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=15328.

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CoordenaÃÃo de AperfeÃoamento de Pessoal de NÃvel Superior<br>Inflammatory Breast Cancer (IBC) is the most aggressive form of locally advanced breast cancer. It is more common in young women and unfavorably, in most of the times, evolves quickly. Presents with typical signs of inflammation such as hyperemia and hyperthermia its pathogenesis and evolution has been associated with possible participation of inflammatory mediators such as cytokines (TNF-α e IL-1β), enzymes (cyclooxygenase-2 [COX-2] and nitric oxide synthase [iNOS]), as well as, transcription factors (Nuclear Factor kappa

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Harry, Vanessa N. "A study of novel MRI techniques as biomarkers of early treatment response in advanced cervical and ovarian cancer." Thesis, University of Aberdeen, 2012. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=186762.

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The management of advanced cervical and ovarian cancers remains a significant challenge as many women fail to respond to recommended therapy, resulting in disease progression and ultimately patient death. Because of tumour heterogeneity, it is rare for all cancers of a particular type to respond to a specific therapy. Many patients therefore receive treatment from which they derive little or no benefit, leading to increased morbidity and costs. A marker that could rapidly predict disease outcome would clearly be beneficial in allowing the administration of tailored therapy while reducing toxic

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Hewson, Emily. "Enabling Real-Time Adaptive Radiotherapy for Multiple Targets." Thesis, The University of Sydney, 2022. https://hdl.handle.net/2123/27841.

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Treating cancer safely and effectively using radiotherapy requires accurate targeting of the tumour. However, internal motion of the tumour due to physiological activity compromises the accuracy of radiotherapy treatment. Managing motion during radiotherapy is further complicated for patients with advanced cancer or oligometastases, where multiple targets can undergo large, independent motion. Prior to this thesis no solution existed to adapt to the motion of independent targets in real time. The aim of this thesis was to develop the first real-time multi-target tracking method. The first two

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Okamura, Ryosuke. "Local control of sphincter-preserving procedures and abdominoperineal resection for locally advanced low rectal cancer: Propensity score matched analysis." Kyoto University, 2018. http://hdl.handle.net/2433/231003.

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Guy, Christopher L. "An Algorithm to Improve Deformable Image Registration Accuracy in Challenging Cases of Locally-Advanced Non-Small Cell Lung Cancer." VCU Scholars Compass, 2017. http://scholarscompass.vcu.edu/etd/4961.

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A common co-pathology of large lung tumors located near the central airways is collapse of portions of lung due to blockage of airflow by the tumor. Not only does the lung volume decrease as collapse occurs, but fluid from capillaries also fills the space no longer occupied by air, greatly altering tissue appearance. During radiotherapy, typically administered to the patient over multiple weeks, the tumor can dramatically shrink in response to the treatment, restoring airflow to the lung sections which were collapsed when therapy began. While return of normal lung function is a positive develo

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Casiraghi, Monica <1976&gt. "Robotic Approach in the Treatment of Locally Advanced (Stage IIIA-pN2) non Small Cell Lung Cancer after Induction Therapy." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2021. http://amsdottorato.unibo.it/9575/1/Tesi.pdf.

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Introduction: Despite there are already many studies on robotic surgery as minimally invasive approach for non-small cell lung cancer (NSCLC) patients, the use of this technique for stage III disease is still poorly described. These are the preliminary results of our prospective study on safety and effectiveness of robotic approach in patients with locally advanced NSCLC, in terms of postoperative complications and oncological outcome. Methods: Since 2016, we prospectively investigated, using standardized questionnaire and protocol, 21 consecutive patients with NSCLC stage IIIA-pN2 (diagnose

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Gagno, Sara. "Innovative strategies for tailoring therapy in cancer patient: pharmacogenetics and hormone therapy personalization in metastatic or locally advanced breast cancer patients treated with Exemestane." Doctoral thesis, Università degli studi di Padova, 2015. http://hdl.handle.net/11577/3423964.

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Background: Response to chemotherapeutic agents is highly variable among patients both in terms of efficacy and tolerability; consequently personalization of drug therapy is one of the main objective in cancer treatment in order to reduce adverse drug reactions (ADRs), improve efficacy while decreasing the costs of treatments. Many factors account for inter-individual differences. Among them, patient’s genetic background has attracted interest for personalization of drug therapy (Pharmacogenetics). Breast cancer (BC) is the female most frequently diagnosed malignancy and the primary cause of

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Gulati, Shuchi. "Phase-1 Study of Metformin in Combination with Concurrent Cisplatin and Radiotherapy in Patients with Locally Advanced Head and Neck Cancer." University of Cincinnati / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1593171585877322.

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Nishizaki, Daisuke. "Laparoscopic versus open surgery for locally advanced rectal cancer: five-year survival outcomes in a large, multicenter, propensity score matched cohort study." Doctoral thesis, Kyoto University, 2021. http://hdl.handle.net/2433/265186.

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Chilwesa, Paul Mambwe. "Comparison of 18F-Fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (18F-FDG PET/CT) and conventional imaging (CI) for locally advanced breast cancer staging: a prospective study from a tertiary hospital cancer centre in Western Cape." Master's thesis, Faculty of Health Sciences, 2019. http://hdl.handle.net/11427/31433.

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Background: Breast cancer is the second most common cancer in adults and the most frequent cancer diagnosed in women. In South Africa, breast cancer accounts for 38.5% of cancers diagnosed in women. Since the presence, extent and location of distant metastases is one important prognostic factor in locally advanced breast cancer (LABC), accurate staging at diagnosis is crucial to ensure patients receive the appropriate treatment. Increasing evidence shows that the use of 18F-FDG PET/CT for disease staging of LABC may improve diagnostic sensitivity. Aim: To prospectively assess the difference

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Zschaeck, Sebastian, Monique Simon, Steffen Löck, et al. "PRONTOX – proton therapy to reduce acute normal tissue toxicity in locally advanced non-small-cell lung carcinomas (NSCLC): study protocol for a randomised controlled trial." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2017. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-219714.

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Background Primary radiochemotherapy with photons is the standard treatment for locally advanced-stage non-small cell lung cancer (NSCLC) patients. Acute radiation-induced side effects such as oesophagitis and radiation pneumonitis limit patients’ quality of life, and the latter can be potentially life-threatening. Due to its distinct physical characteristics, proton therapy enables better sparing of normal tissues, which is supposed to translate into a reduction of radiation-induced side effects. Methods/design This is a single-centre, prospective, randomised controlled, phase II clinical tr

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Zschaeck, Sebastian, Monique Simon, Steffen Löck, et al. "PRONTOX – proton therapy to reduce acute normal tissue toxicity in locally advanced non-small-cell lung carcinomas (NSCLC): study protocol for a randomised controlled trial." BioMed Central, 2016. https://tud.qucosa.de/id/qucosa%3A30184.

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Background Primary radiochemotherapy with photons is the standard treatment for locally advanced-stage non-small cell lung cancer (NSCLC) patients. Acute radiation-induced side effects such as oesophagitis and radiation pneumonitis limit patients’ quality of life, and the latter can be potentially life-threatening. Due to its distinct physical characteristics, proton therapy enables better sparing of normal tissues, which is supposed to translate into a reduction of radiation-induced side effects. Methods/design This is a single-centre, prospective, randomised controlled, phase II clinical tr

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Garieri, Alexandre Pavan. "Produção de VEGF e HIF-1? em pacientes com carcinoma de mama localmente avançado submetidas à quimioterapia neoadjuvante." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/17/17145/tde-24042012-144303/.

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Determinar o valor prognóstico e preditivo do VEGF (vascular endothelial growth factor) e do HIF-1? (Hypoxia-inducible factor-1) em relação à sobrevida livre de doença (SLD) e sobrevida global (SG) em pacientes com carcinoma de mama localmente avançado (CMLA) tratadas primariamente pela quimioterapia neoadjuvante. MATERIAIS E METODOS: VEGF e HIF foram quantificados consecutivamente em plasma de 36 pacientes com CMLA pelo método de ELISA (enzyme labeling immunoassay absorbant) para o VEGF165 e o HIF-1?. O tratamento neoadjuvante foi realizado em todas as pacientes com docetaxel e epirrubicina.

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横井, 香平, та Kohei Yokoi. "隣接臓器合併切除を伴う肺癌手術". 日本肺癌学会, 2006. http://hdl.handle.net/2237/10982.

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Seisen, Thomas. "Caractérisation de l’évolution des tumeurs urothéliales de la voie excrétrice urinaire supérieure après néphrourétérectomie totale A Systematic Review and Meta-analysis of Clinicopathologic Factors Linked to Intravesical Recurrence After Radical Nephroureterectomy to Treat Upper Tract Urothelial Carcinoma Effectiveness of Adjuvant Chemotherapy After Radical Nephroureterectomy for Locally Advanced and/or Positive Regional Lymph Node Upper Tract Urothelial Carcinoma." Thesis, Sorbonne université, 2018. http://www.theses.fr/2018SORUS486.

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Même si la néphrourétérectomie totale représente le traitement de référence des tumeurs de la voie excrétrice urinaire supérieure (TVEUS), il existe un risque élevé de récidive post-opératoire qui peut survenir soit au niveau de la vessie soit dans la loge de résection et/ou sur le plan systémique. L’objectif de ce travail était de caractériser ces différents modes évolutifs. En ce qui concerne la récidive intra-vésicale, une revue systématique de la littérature avec méta-analyse a permis d’identifier les principaux facteurs de risque à la fois cliniques et anatomopathologiques. Par ailleurs,

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Enzo, Maria Vittoria. "Analysis of blood-based markers as predicting tools of pathologic tumour response in rectal cancer patients receiving neo-adjuvant chemoradiotherapy." Doctoral thesis, Università degli studi di Padova, 2013. http://hdl.handle.net/11577/3423392.

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Neo-adjuvant chemo-radio therapy (pCRT) has been accepted as a standard care in the treatment of patients with locally advanced rectal cancer. The multimodality treatment has been established to improve tumour downstaging, pathological complete response, and local disease control. However, the response of individual tumors to the treament is not uniform and ranges from complete response to complete resistance. The discovery of new molecular markers that predict the tumour response is surely of wide interest for personalizing the therapy and reducing time, costs and side effects in the patients

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Díaz, Beveridge Roberto Pedro. "Clinical, radiological and pathological prognostic factors for local relapse, distant metastases and long-term survival in patients with locally advanced rectal cancer treated with neoadjuvant long-course oral fluoropyrimidine- and oxaliplatin-based chemoradiotherapy and total mesorectal excision: Can we move towards a more personalised approach?" Doctoral thesis, Universitat Autònoma de Barcelona, 2016. http://hdl.handle.net/10803/400285.

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Fundamentos: La radioterapia (RT) neoadyuvante previa a la cirugía, ya sea la radioterapia de duración corta (RTDC) como la radioterapia de duración larga combinada con quimioterapia (QT) basada en 5-FU (QRTLD), es usada de forma rutinaria en el manejo del cáncer de recto localmente avanzado, con beneficios consistentes en el riesgo de recidiva local. Desafortunadamente, no se han podido demostrar mejorías en la supervivencia, especialmente en los casos tratados con cirugía radical en forma de una escisión mesorectal total (EMT). El riesgo de sobretratar a algunos pacientes y los posibles efec

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Bibault, Jean-Emmanuel. "Prédiction par Deep Learning de la réponse complète après radiochimiothérapie pré-opératoire du cancer du rectum localement avancé Labeling for big data in radiation oncology: the radiation oncology structures ontology Big data and machine learning in radiation oncology: state of the art and future prospects Deep learning and radiomics predict complete response after neo-adjuvant chemoradiation for locally advanced rectal cancer." Thesis, Sorbonne Paris Cité, 2018. https://wo.app.u-paris.fr/cgi-bin/WebObjects/TheseWeb.woa/wa/show?t=2388&f=17288.

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L’utilisation de systèmes informatiques pour formaliser, organiser et planifier le traitement des patients a abouti à la création et à l’accumulation de quantité importante de données. Ces informations comprennent des caractéristiques démographiques, socio-économiques, cliniques, biologiques, d’imagerie, et, de plus en plus, génomiques. La médecine et sa pratique, fondées sur la sémiologie et la physiopathologie, vont être profondément transformées par ce phénomène. La complexité et la quantité des informations à intégrer pour prendre une décision médicale pourrait dépasser rapidement les capa

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Hamy, Anne-Sophie. "Identification of Factors Predicting Sensitivity or Resistance to Neoadjuvant Chemotherapy in Breast Cancer Neoadjuvant treatment : the future of patients with breast cancer Neoadjuvant treatment for intermediate/high-risk HER2-positive and triple-negative breast cancers: no longer an “option” but an ethical obligation Long-term outcome of the REMAGUS 02 trial, a multicenter randomised phase II trial in locally advanced breast cancer patients treated with neoadjuvant chemotherapy with or without celecoxib or trastuzumab according to HER2 status BIRC5 (survivin) : a pejorative prognostic marker in stage II/III breast cancer with no response to neoadjuvant chemotherapy Beyond Axillary Lymph Node Metastasis, BMI and Menopausal Status Are Prognostic Determinants for Triple-Negative Breast Cancer Treated by Neoadjuvant Chemotherapy Pathological complete response and prognosis after neoadjuvant chemotherapy for HER2-positive breast cancers before and after trastuzumab era: results from a real-life cohort The presence of an in situ component on pre-treatment biopsy is not associated with response to neoadjuvant chemotherapy for breast cancer Chemosensitivity, tumor infiltrating lymphocytes (TILs), and survival of postpartum PABC patients treated by neoadjuvant chemotherapy Lymphovascular invasion after neoadjuvant chemotherapy is strongly associated with poor prognosis in breast carcinoma New insight for pharmacogenomics studies from the transcriptional analysis of two large-scale cancer cell line panels Biological network-driven gene selection identifies a stromal immune module as a key determinant of triple-negative breast carcinoma prognosis A Stromal Immune Module Correlated with the Response to Neoadjuvant Chemotherapy, Prognosis and Lymphocyte Infiltration in HER2-Positive Breast Carcinoma Is Inversely Correlated with Hormonal Pathways Stromal lymphocyte infiltration after neoadjuvant chemotherapy is associated with aggressive residual disease and lower disease-free survival in HER2-positive breast cancer Interaction between molecular subtypes, stromal immune infiltration before and after treatment in breast cancer patients treated with neoadjuvant chemotherapy COX2/PTGS2 Expression Is Predictive of Response to Neoadjuvant Celecoxib in HER2-negative Breast Cancer Patients Celecoxib With Neoadjuvant Chemotherapy for Breast Cancer Might Worsen Outcomes Differentially by COX-2 Expression and ER Status: Exploratory Analysis of the REMAGUS02 Trial Comedications influence immune infiltration and pathological response to neoadjuvant chemotherapy in breast cancer." Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLS129.

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La chimiothérapie néoadjuvante (CNA) est utilisée dans les cancers du sein agressifs ou localement avancés (CS). Au delà des bénéfices cliniques, elle représente une opportunité pour monitorer in vivo la sensibilité d’une tumeur à un traitement.A partir de l’analyse de sets de données de patients traités par CNA, nous souhaitons identifier des mécanismes associes à la résistance ou sensibilité au traitement. Dans la première partie, nous avons évalué des paramètres, cliniques, anatomopathologiques et transcriptomiques. Nous avons démontré que des éléments non explorés comme la présence d’embol

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Li, Jie, and 李杰. "Prognostic significance of computed tomography-based body composition analysis in patients with locally advanced cervical cancer." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/avn7e7.

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Govindarajan, Anand. "Surgical management of locally advanced colorectal cancer: A population-based study." 2007. http://link.library.utoronto.ca/eir/EIRdetail.cfm?Resources__ID=788750&T=F.

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GIARDINO, Alessandro. "Radiofrequency ablation - analysis of antitumor immunostimulatory patterns in locally advanced pancreatic cancer." Doctoral thesis, 2016. http://hdl.handle.net/11562/938526.

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La Radiofrequenza è un metodo ablativo locale basata sulla coagulazione termica e denaturazione proteica. E 'stato ampiamente applicato in molti tumori solidi metastatici non operabili come fegato, polmone, della prostata, del rene, osso, seno, ghiandola surrenale e la milza, ma la sua applicazione nel cancro del pancreas è stata finora molto limitata. Il nostro gruppo ha recentemente dimostrato la fattibilità e la sicurezza della procedura nel tumore pancreatico localmente avanzato, con un tasso di complicanze del 24% e un tasso di mortalità del 2%. Tuttavia, con il miglioramento della curva

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Lo, Jo-Lin, and 羅若玲. "The Cross-over Survival curve of Neoadjuvant Chemoradiation in Locally Advanced Esophageal Cancer." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/49847457074382787486.

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碩士<br>臺灣大學<br>流行病學研究所<br>98<br>Although the concept and method of treating cancer have substantial improvement in recent years, there is limited improvement in treatment of esophageal cancer. Radical esophagectomy is still the mainstay for the resectable esophageal cancer, which provided the chance for long-term survival and better local control rate. However, the five-year survival is still low for esophagectomy, which is only 0~10%. Current trend of treatment in locally advanced esophageal cancer is tri-modality treatment (neoadjuvant chemoradiotherapy and surgery). Over ten randomized cont

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CHAN, SI-WA, and 陳詩華. "Dynamic contrast enhanced MRI in monitoring early response of locally advanced breast cancer undergoing neoadjuvant chemotherapy." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/50331488860547793179.

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碩士<br>逢甲大學<br>生醫資訊暨生醫工程碩士學位學程<br>98<br>Patients who present with late stage disease, which is frequently locally advanced (LABC), will be treated initially with neoadjuvant chemotherapy to down-stage the disease, followed by surgery and post-operative therapies. Monitoring a patient’s response to neoadjuvant chemotherapy is usually undertaken by clinical examination, mammography and ultrasound. Unfortunately, there is a poor correlation between the histological appearances of the tumor and measurements obtained by physical examination, mammography or ultrasound. Techniques for magnetic resonan

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Chang, Chih-Wen, and 張智雯. "Cost-effectiveness of Immunotherapy for Locally Advanced or Metastatic Non-small Cell Lung Cancer after Chemotherapy." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/8q3t32.

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碩士<br>國立陽明大學<br>醫務管理研究所<br>107<br>Background Lung cancer has ranked the top mortality of cancer for seven years in Taiwan. About 13,488 new cases of lung cancer were diagnosed in 2016 in Taiwan, of which 80%-85% were classified as non-small cell lung cancer (NSCLC). Clinical trials show that immune checkpoint inhibitors, such as Nivolumab, Pembrolizumab and Atezolizumab, are effective treatment options for NSCLC patients. The objective of this analysis was to assess the cost-effectiveness of Nivolumab, Pembrolizumab and Atezolizumab compared with Docetaxel as the second-line treatment for pati

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Wang, Wei-Na, and 王維那. "A cost-outcome analysis of androgen deprivation therapy and androgen deprivation therapy combine radiotherapy for locally advanced prostate cancer." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/28097547706589051855.

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碩士<br>高雄醫學大學<br>醫務管理學研究所碩士在職專班<br>99<br>Purpose 1. Comparison of androgen deprivation therapy to androgen deprivation therapy with radiation therapy at the patient characteristics and hospital characteristics of the different medical treatment. 2. Comparison of androgen deprivation therapy to androgen deprivation therapy with radiation therapy at the cost difference. 3. Comparison of combined androgen deprivation therapy and differences in the effect of radiation therapy. 4. Androgen deprivation therapy to androgen deprivation therapy with radiation therapy Comparison of cost-effectiveness an

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Kroon, Hidde Maarten. "Management of Lateral Lymph Node Metastasis in Rectal Cancer." Thesis, 2022. https://hdl.handle.net/2440/135590.

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Introduction: Pre-treatment abnormal lateral lymph nodes (LLNs) are present in approximately 20% of patients with locally advanced rectal cancer. Western treatment of LLNs consists of neoadjuvant (chemo)radiotherapy (nCRT) followed by total mesorectal excision (TME), meaning these nodes are not removed surgically. There is, however, potential benefit in performing an additional lateral lymph node dissection (LLND) as enlarged LLNs have been shown to be predictive for local recurrence. Furthermore, the impact on oncological outcomes when enlarged LLNs harbour malignant features is currently unk

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Chen, Chin-Fan, and 陳欽凡. "A Observational Study of the Efficacy and Safety of Chemoradiotherapy in the Pre-operative Treatment of Taiwanese Patients with Locally Advanced Rectal Cancer." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/42772178033656914289.

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碩士<br>高雄醫學大學<br>臨床醫學研究所<br>100<br>Topic 1 Background and Objectives: This study is to evaluate the safety and efficacy of preoperative radiotherapy (RT), combined with bolus infusional 5-fluorouracil (5-FU) or oral capecitabine, in patients with locally advanced rectal cancer (LARC). Materials and Methods: Seventy-four patients were retrospectively analyzed. Twenty-seven patients were treated with 5-FU (350 mg/m2 IV bolus) and leucovorin (20 mg/m2 IV bolus) for 5 days/week during week 1 and 5 of RT. Forty-seven patients were treated with capecitabine (850 mg/m2, twice daily for 5 days/week).

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Huang, Chun-Ming, and 黃鈞民. "Pre-operative concurrent chemoradiotherapy for patients with locally advanced or low rectal cancer-The impact of clinical parameters and pathologic characteristics on prognosis." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/98583915519428798168.

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碩士<br>高雄醫學大學<br>醫學研究所<br>100<br>The incidence of colorectal cancer (CRC) in Taiwan has been rapidly increasing in the past few years, and CRC is the second most common cancer and also the third leading cause of cancer death in Taiwan. For locally advanced rectal cancer (T3-4 or N1-2), preoperative chemoradiotherapy (CCRT) has been demonstrated to achieve a lower local recurrence rate and good sphincter preservation rate. Several prospective and retrospective analyses suggest that pathological stage of disease after preoperative CCRT has a significant prognostic impact on disease-free and overa

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