Academic literature on the topic 'Locklear system'

This article discusses group intelligence behavior, the use of unmanned systems called "drones", swarm intelligence and military intelligence observed in nature, ways to use the military drone "Swarm" in combat, the importance of human-AI cooperation, human control for AI necessity, improvement of command and control structures was discussed.

During the movement of the tractor in the unit with the lockless grabs on the roughness of the terrain on the cuttings there are fluctuations that cause jumps of the working fluid in the hydraulic system. This leads to loss of fluid through the gaps and seals of the moving elements of the pump and hydraulic cylinders. For laboratory studies of these phenomena, a laboratory installation was made with the introduction of a pneumatic-hydraulic accumulator of the A5579-0 series into the hydraulic circuit. Laboratory tests were carried out, which showed that the pneumohydraulic battery allows, due to the energy accumulated during operation, to reduce the pressure spikes of the working fluid in the hydraulic system. This reduces the dynamic load on the metal structure of the grip, the hydraulic pump drive and the tractor transmission, as well as increases the volumetric efficiency. After processing waveforms of operating modes to capture with energy saving hydraulic drive using the program STATISTICA was established replications of individual load magnitudes and histograms of pressure without the use of a hydropneumatic accumulator and to its use. It was found that the energy recovery system reduces the pressure spikes of the working fluid during transients by 1.4-1.7 times and allows you to store power within 1.7 ... 2.1 kW.

The work is devoted to development of a smart lighting system that is able to change correlated colour temperature and consists of tunable 4-components RGBW clusters controlled via three channels. It is shown that fixing a ratio between the intensities of white and red LEDs at a level of 100:9 enables obtaining high values of colour rendering in a wide range of correlated colour temperatures. A control of 3 from 4 channels simplifies the system. The influence of the red LED on CRI and luminous efficiency is analysed. Full Text: PDF References:J. Gooley, S. Rajaratnam, G. Brainard, R. Kronauer, C. Czeisler and S. Lockley, "Spectral Responses of the Human Circadian System Depend on the Irradiance and Duration of Exposure to Light", Sci Transl Med 2, 31 (2010) [CrossRef]A. Borisuit, F. Linhart, J. Scartexxini, M. Munch, Light Res Technol 47, 192 (2014) [CrossRef]Q. Dai, W. Cai, L. Hao, W Shi and Z. Wang, Light Res Technol 50 (8), 1198-1211 (2017), [CrossRef]V. Kornaga, V. Sorokin, A. Rybalochka, O. Oliinyk and N. Kornaga, Semicond Phys Quantum Electron Optoelectron 18, 302 (2015) [CrossRef]Illuminating Engineering Society, ANSI/IES TM-30-18 IES method for evaluating light source color rendition (2018). New York, NY[DirectLink]Commission International de l'Éclairage, CIE 224:2017 Colour fidelity index for accurate scientific use (2017). Vienna [CrossRef]V. Kornaga, D. Kalustova and O. Oliynyk, Int Sci Conf "Light and power eng: hist, probl, perspect" 6, 43 (2018) [DirectLink]

AbstractINTRODUCTION: For over 50 yr, investigators have studied the physiological adaptations of the human system during short- and long-duration spaceflight exposures. Much of the knowledge gained in developing health countermeasures for astronauts onboard the International Space Station demonstrate terrestrial applications. To date, a systematic process for translating these space applications to terrestrial human health has yet to be defined.METHODS: In the summer of 2017, a team of 38 international scientists launched the Bellagio ll Summit Initiative. The goals of the Summit were: 1) To identify space medicine findings and countermeasures with highest probability for future terrestrial applications; and 2) To develop a roadmap for translation of these countermeasures to future terrestrial application. The team reviewed public domain literature, NASA databases, and evidence books within the framework of the five-stage National Institutes of Health (NIH) translation science model, and the NASA two-stage translation model. Teams then analyzed and discussed interdisciplinary findings to determine the most significant evidence-based countermeasures sufficiently developed for terrestrial application.RESULTS: Teams identified published human spaceflight research and applied translational science models to define mature products for terrestrial clinical practice.CONCLUSIONS: The Bellagio ll Summit identified a snapshot of space medicine research and mature science with the highest probability of translation and developed a Roadmap of terrestrial application from space medicine-derived countermeasures. These evidence-based findings can provide guidance regarding the terrestrial applications of best practices, countermeasures, and clinical protocols currently used in spaceflight.Sides MB, Johnston SL III, Sirek A, Lee PH, Blue RS, Antonsen EL, Basner M, Douglas GL, Epstein A, Flynn-Evans EE, Gallagher MB, Hayes J, Lee SMC, Lockley SW, Monseur B, Nelson NG, Sargsyan A, Smith SM, Stenger MB, Stepanek J, Zwart SR; Bellagio II Team. Bellagio II report: terrestrial applications of space medicine research. Aerosp Med Hum Perform. 2021; 92(8):650669.

Abstract Introduction. Drug resistance results in dismal outcomes for cancer patients. Carboplatin is the backbone of treatment for high grade serous ovarian cancer (HGSOC), augmented by PARP inhibitor (PARPi) maintenance therapy for patients with tumors deficient in homologous recombination repair (HRR). However, most tumors evolve resistance to both drugs and no other agents, including immunotherapies, have improved survival. Therapeutic strategies that acknowledge and target this evolution offer an opportunity to preserve drug sensitivity and extend progression-free survival. Adaptive Therapy (AT) is one such approach. AT is based on the premise that fitness costs are incurred as resistance evolves, so that competition between drug-sensitive and resistant cells favors sensitive cells when drug is absent. We have developed AT in HGSOC from proof-of-concept to a randomized phase 2 trial called ACTOv, (Adaptive ChemoTherapy in Ovarian cancer) comparing carboplatin AT to standard carboplatin dosing in patients with relapsed, platinum sensitive high grade serous and endometrioid ovarian cancer. We are now extending our work to explore the evolutionary dynamics between PARPi-sensitive and PARPi-resistant HGSOC populations. Methods. We evolved resistance to cisplatin and carboplatin in HGSOC cell lines in vitro and in vivo via carboplatin treatment of mice with intraperitoneal xenografts. Resistance to cisplatin, carboplatin and the PARPis niraparib and olaparib was quantified by live/dead assays in the entire cell panel. Co-cultures of sensitive and resistant cells were created in vitro in low resource conditions (low serum or low glucose) to expose fitness deficits. Population growth dynamics were quantified over time using the Sartorius Incucyte™ Live Cell Analysis System. Mechanisms underpinning these dynamics were explored by flow cytometry to analyze cell cycle and expression of the standard apoptotic maker, Annexin V. HRR status was determined functionally by immunofluorescence for Rad51 and γH2Ax co-localization and for micronuclei formation, while BRCA expression was examined by western blot. In vivo co-cultures of GFP-expressing sensitive cells and RFP-expressing resistant cells enabled tracking of sensitive/resistant cell growth over time by qPCR. Sensitive/resistant cells were further examined by immunohistochemistry (IHC) in excised tumors. The influence of drug therapy on in vitro co-cultures of sensitive (GFP) and resistant (RFP) HGSOC was quantified by flow cytometry. AT was compared to standard carboplatin dosing in mice with HGSOC xenografts and excised tumors were examined by IHC. Cumulative drug dose and murine survival were compared. Cell-free DNA (cfDNA) and tumor biopsies were obtained from HGSOC patients during carboplatin and PARPi treatment and subjected to low pass whole genome sequencing and analysis with our published bioinformatic pipeline (LiquidCNA) that estimates the size of the emergent resistant population. Finally, established patient datasets were examined to adapt our pre-clinical discoveries for clinical testing in the ACTOv trial. Results. Cell viability assays confirmed platinum resistance. One murine HGSOC cell line with evolved platinum resistance (60577R3) was also resistant to olaparib and niraparib in vitro, whereas there was no difference in PARPi sensitivity in the other sensitive/resistant cell pairs. Fitness deficits of resistance in the absence of drug, were exposed by low resource co-cultures in vitro in four out of five HGSOC cell lines with evolved platinum resistance. Conversely, the resistant subline, 60577R3, exhibited greater fitness than sensitive, ancestral cells (60577). Resistant populations with reduced fitness declined due to both reduced proliferation and increased apoptosis in vitro and in vivo when drug was absent. Rad51 foci formation in response to double strand breaks was observed in platinum and PARPi-resistant 60577R3 cells but not sensitive 60577 indicating that functional HRR had been restored in 60577R3 as resistance evolved. Consistent with this, 60577R3 cells also made fewer segregation errors during mitosis. Western blot confirmed expression of BRCA1 in 60577R3 but not 60577 cells. Platinum treatment of in vitro co-cultures demonstrated that the size of sensitive and resistant HGSOC populations fluctuated with drug therapy and that fitter, sensitive cells re-grew when drug was withdrawn. In vivo, AT significantly prolonged survival of murine ovarian cancer models compared to standard carboplatin dosing without increasing mean daily drug dose or drug-related toxicity. Escape from control by AT was associated with growth of resistant cells in our in vivo models. In HGSOC patients, LiqCNA analysis of cfDNA obtained longitudinally during treatment showed sub-clonal selection through therapy and demonstrated that LiqCNA correlates with increases in the serum tumor marker, CA125, a proxy for disease progression. Existing clinical datasets of CA125 during standard carboplatin treatment defined the parameters for dose adaptations in patients receiving AT in the ACTOv trial. Conclusions. Platinum resistance can be associated with fitness deficits in HGSOC, which can be exploited by AT to preserve platinum sensitivity over the long-term and prolong survival. BRCA reversion mutations are the most well-documented cause of acquired PARPi resistance. Our data imply that this may provide a fitness advantage for HGSOC cells with implications for PARPi maintenance treatment and response to subsequent lines of therapy. These discoveries paved the way for us to launch the ACTOv trial, which is currently recruiting patients in ten NHS hospitals throughout the UK. ACTOv patients will provide biopsies and very frequent blood samples for circulating tumor DNA (total ∼1,400 samples from 80 patients), enabling us to interrogate clonal evolution during standard and adaptive therapy and relate this to clinical outcome. LiqCNA could provide a biomarker for the emergence of drug resistance to direct AT in second generation clinical trials. Citation Format: Mohammed Ateeb Khan, Helen Hockings, Maximilian Mossner, Ann-Marie Baker, Hall Amy, Robert L. Hollis, Weini Huang, Eszter Lakatos, Charlie Gourley, Trevor A. Graham, Michelle Lockley. Translating adaptive therapy to ovarian cancer patients [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2025; Part 2 (Late-Breaking, Clinical Trial, and Invited Abstracts); 2025 Apr 25-30; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2025;85(8_Suppl_2):Abstract nr SY43-01.

In Today's age of Tetra Scale computing, the application has become more data intensive than ever. The increased data volume from applications, in now tackling larger and larger problems, and has fuelled the need for efficient management of this data. In this paper, a technique called Content Addressable Storage or CAS, for managing large volume of data is evaluated. This evaluation focuses on the benefits and demerits of using CAS it focuses, i) improved application performance via lockless and lightweight synchronization ofaccess to shared storage data, ii) improved cache performance, iii) increase in storage capacity and, iv) increase network bandwidth. The presented design of a CAS-Based file store significantly improves the storage performance that provides lightweight lock less user defined consistency semantics. As a result, this file system shows a 28% increase in read bandwidth and 13% increase in write bandwidth, over a popular file system in common use. In this paper the potential benefits of using CAS for a virtual machine are estimated. The study also explains mobility application for active use and public deployment.

Abstract In data centers, the Storage Performance Development Kit (SPDK) para-virtualization architecture is an efficient solution for non-volatile memory express (NVMe) solid-state drive (SSD) virtualization but faces challenges in maintaining performance fairness and isolation due to storage resource competition among multi-tenants. However, the existing Quality of Service method in SPDK fails to ensure proportional I/O sharing among multi-tenants. Providing fairness and isolation while maintaining high storage utilization in SPDK remains a challenge. In this paper, we propose BLFair to address this problem. Specifically, BLFair implements proportional I/O sharing for multi-tenants in the SPDK. The design of BLFair can effectively reduce the high time complexity caused by the ordering and the overhead of maintaining the virtual clock. Moreover, BLFair allows for achieving a trade-off between proportional I/O sharing and maximizing storage utilization. BLFair also uses the lockless ring mechanism to achieve scalability for cross-core operation. We have implemented a prototype system of BLFair in SPDK. Finally, we conduct evaluations with different workloads in both local storage and NVMe over RDMA fabric environments. The results show that our method can achieve fairness and scalability. BLFair can achieve up to 7.09x 99.99th latency reduction compared to the system with no fairness. Evaluation results in realistic workloads also show that BLFair outperforms other methods.

This paper presents findings on the correspondence of levels of digital systems and media use with a range of socio-economic and demographic measures in the U.K. Most research on inequalities in regard to digital systems and media has focused on access and skills. Building on prior work (Yates and Lockley, 2018; Yates, et al., 2015) we argue that inequalities in regard to digital systems and media are better understood around types of user and their correspondence to other key social variables — rather than solely individual skills and access. The analysis presented here covers a range of key demographic variables, especially those that are markers of distinct social disadvantage. We find that those not using the Internet have distinct characteristics — predominantly around age, education and deprivation levels. We also find that those undertaking limited uses (overall limited use or a very narrow range of uses) are all predominantly from lower socio-economic status backgrounds with variations due to age and education. The data used for the analysis is the recent U.K. Ofcom 2018–19 (n = 1,882) media literacy survey. The paper uses latent class analysis methods to inductively define user types. Multinomial and binary logistic regression are used to explore the correspondence of latent class group membership to key demographic variables. These insights have direct U.K. and international policy relevance as they are key to the development of strategies to tackle ongoing digital inequalities in U.K. society.

Lumbee advocates believed that Lumbees should harness the full power of self-determination provided by the federal government. Federal recognition does not legitimize a tribe’s identity, but it does give a tribe’s inherent sovereignty a unique place within the American political system. This chapter outlines the Lumbee fight for federal recognition throughout the late twentieth and early twenty-first centuries. Opposition came from the federal government, Washington political infighting, and other Indian tribes. Despite disappointment at the federal level, Lumbee organizations worked together to create a tribal government and constitution for the Lumbee people, as well as debated with each other about how best to do that. The topic of gaming was particularly controversial. Eventually Lumbees decided on an electoral system of government with representation on a district basis. The Lumbee constitution defined two important aspects of Lumbee identity: kinship and place.Important players in the Lumbee fight for sovereignty included Arlinda Locklear, Julian Pierce, Helen Maynor Schierbeck, and Dalton Brooks.

The article considers the relevance of improving the energy efficiency of forest machines through the introduction of energysaving hydraulic systems in lockless skidding units. The main types of operations for the transportation of the assortment are considered. The classification of skidding operations and the tech-nical means used to perform them are given. A promising energy-saving hydraulic circuit is considered, in which the process of energy recovery is realized by us-ing an additional hydraulic cylinder and a hydraulic accumulator. A mathematical model of a promising scheme of a skidding unit with an energy recovery system, a model of the movement of the MTZ-82 tractor, aggregated by a skidder, has been compiled.