Relevant bibliographies by topics / Long-acting release kinetics

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Academic literature on the topic 'Long-acting release kinetics'

Author: Grafiati
Published: 10 December 2022
Last updated: 31 July 2025

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Journal articles on the topic "Long-acting release kinetics"

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Kim, Soyoung, Brian Cicali, Michelle Pressly, et al. "Model-Based Analysis of In Vivo Release Data of Levonorgestrel Implants: Projecting Long-Term Systemic Exposure." Pharmaceutics 15, no. 5 (2023): 1393. http://dx.doi.org/10.3390/pharmaceutics15051393.

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Levonorgestrel (LNG) is a progestin used in many contraceptive formulations, including subcutaneous implants. There is an unmet need for developing long-acting formulations for LNG. To develop long-acting formulations, release functions need to be investigated for LNG implant. Therefore, a release model was developed and integrated into an LNG physiologically-based pharmacokinetic (PBPK) model. Utilizing a previously developed LNG PBPK model, subcutaneous administration of 150 mg LNG was implemented into the modeling framework. To mimic LNG release, ten functions incorporating formulation-spec
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Verma, Malvika, Jacqueline N. Chu, John A. F. Salama, et al. "Development of a long-acting direct-acting antiviral system for hepatitis C virus treatment in swine." Proceedings of the National Academy of Sciences 117, no. 22 (2020): 11987–94. http://dx.doi.org/10.1073/pnas.2004746117.

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Chronic hepatitis C virus (HCV) infection is a leading cause of cirrhosis worldwide and kills more Americans than 59 other infections, including HIV and tuberculosis, combined. While direct-acting antiviral (DAA) treatments are effective, limited uptake of therapy, particularly in high-risk groups, remains a substantial barrier to eliminating HCV. We developed a long-acting DAA system (LA-DAAS) capable of prolonged dosing and explored its cost-effectiveness. We designed a retrievable coil-shaped LA-DAAS compatible with nasogastric tube administration and the capacity to encapsulate and release
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Cortez, John M., Rafaela Quintero, John A. Moss, Martin Beliveau, Thomas J. Smith, and Marc M. Baum. "Pharmacokinetics of Injectable, Long-Acting Nevirapine for HIV Prophylaxis in Breastfeeding Infants." Antimicrobial Agents and Chemotherapy 59, no. 1 (2014): 59–66. http://dx.doi.org/10.1128/aac.03906-14.

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ABSTRACTMother-to-child transmission (MTCT) of HIV-1 remains a global health problem. The World Health Organization (WHO) recommendations advise the administration of a once-daily, oral, prophylactic regimen of the nonnucleoside reverse transcriptase inhibitor nevirapine (NVP) from birth until 4 to 6 weeks of age for infants born to HIV-infected mothers in regions without access to safe and nutritionally adequate alternatives to breast milk. A critical factor driving the successful implementation of the WHO guidelines involves sustaining high adherence to the frequent dosing. With these challe
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Son, Young Jin, Tae Han Yun, Jeong Gyun Lee, Kyu Ho Bang, and Kyeong Soo Kim. "Development and Characterization of Long-Acting Injectable Risperidone Microspheres Using Biodegradable Polymers: Formulation Optimization and Release Kinetics." Processes 12, no. 12 (2024): 2858. https://doi.org/10.3390/pr12122858.

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The aim of this study was to develop a long-acting injectable formulation of risperidone using polylactic acid (PLA) or poly (lactic-co-glycolic acid) (PLGA), a biodegradable and biocompatible polymer. Risperidone microspheres (RMs) were prepared by creating an O/W emulsion using dichloromethane (DCM) as a solvent and then employing the solvent evaporation method. The RMs were prepared with four different risperidone-to-PLGA ratios (1:1, 1:1.3, 1:2, and 1:3 (w/w)), and each ratio was subjected to the same manufacturing process. The physicochemical properties of the prepared RMs, such as their
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Yan, Xieguo, Shiqiang Wang, and Kaoxiang Sun. "Long-Acting Risperidone Dual Control System: Preparation, Characterization and Evaluation In Vitro and In Vivo." Pharmaceutics 13, no. 8 (2021): 1210. http://dx.doi.org/10.3390/pharmaceutics13081210.

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Schizophrenia, a psychiatric disorder, requires long-term treatment; however, large fluctuations in blood drug concentration increase the risk of adverse reactions. We prepared a long-term risperidone (RIS) implantation system that can stabilize RIS release and established in-vitro and in-vivo evaluation systems. Cumulative release, drug loading, and entrapment efficiency were used as evaluation indicators to evaluate the effects of different pore formers, polymer ratios, porogen concentrations, and oil–water ratios on a RIS implant (RIS-IM). We also built a mathematical model to identify the
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Gohn, Anne M., Amy Nolte, Ethan Ravotti, et al. "Dissolution from Ethylene Vinyl Acetate Copolymer Long-Acting Implants: Effect of Model Active Ingredient Size and Shape." Pharmaceutics 14, no. 6 (2022): 1139. http://dx.doi.org/10.3390/pharmaceutics14061139.

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In recent pharmaceutical applications, an active pharmaceutical ingredient (API) can be mixed with a polymer material to yield a composite long-acting drug-delivery device. These devices boast higher patient compliance, localized drug delivery, and lower dosage concentrations, which can increase patient safety. As a laboratory-safe option, calcium carbonate (CaCO3) was used as a drug surrogate to mimic the release kinetics of a low-solubility API. The release of CaCO3 from a poly(ethylene vinyl acetate) (EVA) polymer matrix was studied in ultra-high-purity water. The geometry of CaCO3, along w
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Wojcik-Pastuszka, Dorota, Justyna Krzak, Bartosz Macikowski, Ryszard Berkowski, Bogdan Osiński, and Witold Musiał. "Evaluation of the Release Kinetics of a Pharmacologically Active Substance from Model Intra-Articular Implants Replacing the Cruciate Ligaments of the Knee." Materials 12, no. 8 (2019): 1202. http://dx.doi.org/10.3390/ma12081202.

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Implants are readily applied as a convenient method of therapy. There is great interest in the prolonged release of active substances from implants. The objective of this work was to evaluate the dissolution kinetics of steroidal anti-inflammatory preparation (SAP) released from novel implants, and to test the influence of the technology on SAP release kinetics. The proposed long-acting preparations may overcome difficulties resulting from repeated injections and often visits to ambulatory clinic, as the stabilizing function of the artificial ligament would be enriched with pharmacological act
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Comets, Emmanuelle, France Mentré, Ryosei Kawai, Fritz Nimmerfall, Peter Marbach, and Jacky Vonderscher. "Modeling the Kinetics of Release of Octreotide from Long‐Acting Formulations Injected Intramuscularly in Rabbits." Journal of Pharmaceutical Sciences 89, no. 9 (2000): 1123–33. http://dx.doi.org/10.1002/1520-6017(200009)89:9<1123::aid-jps4>3.0.co;2-k.

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Ishkaeva, Rezeda A., Nail N. Khaertdinov, Aleksey V. Yakovlev, et al. "Characterization of Glutathione Dithiophosphates as Long-Acting H2S Donors." International Journal of Molecular Sciences 24, no. 13 (2023): 11063. http://dx.doi.org/10.3390/ijms241311063.

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Considering the important cytoprotective and signaling roles but relatively narrow therapeutic index of hydrogen sulfide (H2S), advanced H2S donors are required to achieve a therapeutic effect. In this study, we proposed glutathione dithiophosphates as new combination donors of H2S and glutathione. The kinetics of H2S formation in dithiophosphate solutions suggested a continuous H2S release by the donors, which was higher for the dithiophosphate of reduced glutathione than oxidized glutathione. The compounds, unlike NaHS, inhibited the proliferation of C2C12 myoblasts at submillimolar concentr
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Yue, Zhaoyan. "The Release Kinetics of Long-Lasting Tracer Particles in Horizontal Wells." Scientific Journal of Technology 7, no. 2 (2025): 101–11. https://doi.org/10.54691/hwvb0g03.

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In the context of China's ongoing development of unconventional oil and gas reservoirs, horizontal well segmental fracturing technology currently holds a dominant position. Accurate and effective monitoring of fracture parameters and production profiles is imperative for the efficient development of oil and gas resources. Tracer monitoring technology has emerged as a pivotal method for monitoring horizontal wells fractured in tight oil segments. This technology involves the injection of slow-release tracer particles into the fractured fracture, followed by the continuous monitoring of the trac
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Books on the topic "Long-acting release kinetics"

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Cavacuiti, Christopher. The Pharmacology of Opioids (DRAFT). Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190265366.003.0008.

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This chapter focuses on the attributes of and component medications within the class of opioids, emphasizing kinetics, dynamics, and therapeutic and adverse effects. To help patients make informed decisions about opioid use, the clinicians prescribing these medications must be able to explain when opioids are likely to help and when they are likely to do harm. Subclasses of opioids include phenanthrenes, benzomorphans, phenylpiperidines, and diphenylheptanes; examples are given of each, with respective utilities and limitations. A discussion then follows of pharmacodynamics, pharmacokinetics,
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Conference papers on the topic "Long-acting release kinetics"

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Åman, Rafael, Pavel Ponomarev, Lauri O. Luostarinen, Heikki Handroos, Juha Pyrhönen, and Laurila Lasse. "Experimental Analysis of Electro-Hydraulic Hybrid Actuator System for Off-Highway Working Vehicles." In 8th FPNI Ph.D Symposium on Fluid Power. American Society of Mechanical Engineers, 2014. http://dx.doi.org/10.1115/fpni2014-7826.

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Electro-hydraulic hybrid power transmission system can save energy and thus reduce the pollution while maintaining the same performance in comparison to the conventional fluid power system in off-highway working vehicles. This paper introduces experimental analysis of an electro-hydraulic hybrid actuator system specially developed for the recuperation of the potential and kinetic energy in off-highway working vehicles. In this compact assembly all the components are located near each other to save space. Proposed hybrid actuator system can be controlled directly by an electrical frequency conv
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