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1

KIGS/KIMS Expert Meeting on Growth and Growth Disorders (4th 1999 Taormina, Italy). Analytical methods in clinical osteology: Useful predictors of long-term outcomes or a waste of time and money? : 4th KIGS/KIMS Expert Meeting on Growth and Growth Disorders, Taormina, November 25-26, 1999. Edited by Cowell Christopher T. 1950-. Karger, 2000.

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2

Skiba, Grzegorz. Fizjologiczne, żywieniowe i genetyczne uwarunkowania właściwości kości rosnących świń. The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, 2020. http://dx.doi.org/10.22358/mono_gs_2020.

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Bones are multifunctional passive organs of movement that supports soft tissue and directly attached muscles. They also protect internal organs and are a reserve of calcium, phosphorus and magnesium. Each bone is covered with periosteum, and the adjacent bone surfaces are covered by articular cartilage. Histologically, the bone is an organ composed of many different tissues. The main component is bone tissue (cortical and spongy) composed of a set of bone cells and intercellular substance (mineral and organic), it also contains fat, hematopoietic (bone marrow) and cartilaginous tissue. Bones a
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3

Wheeler, Donna L. The short- and long-term effects of methotrexate on the rat skeleton. 1993.

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4

Fairbank, Jeremy. Neuromuscular and skeletal manifestations of neurofibromatosis. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780199550647.003.0013.

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5

Price, Susan. Genetic bone and joint disease. Edited by Patrick Davey and David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0276.

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Genetic conditions affecting the skeleton and supporting structures are individually rare and heterogeneous. This chapter presents an approach to assessing patients with suspected skeletal dysplasia, osteogenesis imperfecta, Marfan syndrome, and Ehlers–Danlos syndrome. Skeletal dysplasias are caused by abnormalities of bone growth and modelling; the commonest non-lethal type is achondroplasia, with an incidence of 1/10 000 to 1/30 000. The typical presentation of osteogenesis imperfecta is with multiple fractures, sometimes prenatally. There may be associated short stature, bone deformity, den
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6

Lories, Rik. Mechanisms of bone destruction and proliferation in psoriatic arthritis. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198737582.003.0008.

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Psoriatic arthritis is a chronic inflammatory joint disease that can affect both the peripheral and axial skeleton. The clinical presentation of psoriatic arthritis is very heterogeneous and different subforms have been described. Structural damage to the joint is a feared complication of psoriatic arthritis. The severity of joint inflammation and subsequent damage can range from mild to extreme. Over the last decade, insights into the molecular and cellular mechanisms that underlie the skeletal changes in psoriatic arthritis have gradually increased although translational validation of concep
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7

Cormick, Craig, ed. Ned Kelly. CSIRO Publishing, 2014. http://dx.doi.org/10.1071/9781486301775.

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Ned Kelly was hanged at the Old Melbourne Gaol on 11 November 1880, and his body buried in the graveyard there. Many stories emerged about his skull being separated and used as a paperweight or trophy, and it was finally put on display at the museum of the Old Melbourne Gaol — until it was stolen in 1978. 
 
 It wasn’t only Ned Kelly’s skull that went missing. After the closure of the Old Melbourne Gaol in 1929, the remains of deceased prisoners were exhumed and reinterred in mass graves at Pentridge Prison. The exact location of these graves was unknown until 2002, when the bones of
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8

Hughes, Jim. Orthopaedics. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198813170.003.0008.

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This chapter covers the basic approaches and techniques used in orthopaedic surgery, including the insertion and positioning of hardware and fixators, closed and open techniques (including manipulation under anaesthetic), and the typical imaging requirements for these. The discussion includes elective and trauma cases, as well as emergency procedures that may be performed out of regular working hours. They generally involve either repair to the skeleton and joints after injury (e.g. resiting a dislocated joint or aligning and supporting a fractured long bone) or alterations (such as fusion or
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9

Mays, Simon. The Study of Growth in Skeletal Populations. Edited by Sally Crawford, Dawn M. Hadley, and Gillian Shepherd. Oxford University Press, 2018. http://dx.doi.org/10.1093/oxfordhb/9780199670697.013.4.

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Classically, the study of skeletal growth in earlier human populations has involved the study of long-bone lengths versus dental age, making comparisons between archaeological groups or between archaeological and modern populations. Although this continues to be an important avenue of scholarly enquiry in archaeological growth studies, some important new directions have recently been explored. There has also been an increased diversity to the statistical methods used to model and investigate skeletal growth in archaeological populations, and increased recognition of some of the limitations of
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10

Sabapathay, S. Raja, and Roderick Dunn. Reconstruction. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198757689.003.0007.

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The principles of upper limb reconstruction are to perform careful wound excision, fix the skeleton, reconstruct vessels, nerves, tendons, and bone as required (either immediate or delayed), and to obtain primary healing of the soft tissues with healthy vascularized tissue. This enables early movement—ideally, supervised by hand therapists—and generally results in a good outcome. In particular, delayed healing and immobility can lead to long-term morbidity. We provide a general overview of the principles of surgical incisions in the hand, wound care, and suturing, and discuss the use of skin g
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11

Gluckman, Sir Peter, Mark Hanson, Chong Yap Seng, and Anne Bardsley. Vitamin D in pregnancy and breastfeeding. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780198722700.003.0015.

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Vitamin D, which is synthesized in skin exposed to UV light, or is consumed in the diet, plays a key role in maintaining bone integrity via the regulation of calcium and phosphorus homeostasis. It also influences a number of extra-skeletal processes, including immune function and blood glucose homeostasis. Maternal vitamin D deficiency in pregnancy leads to poor fetal skeletal mineralization in utero that can manifest as rickets in newborns. In addition to skeletal effects, women with very low vitamin D status face increased risks of other adverse pregnancy outcomes and possible long-term effe
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12

Barrett, James H. Medieval Fishing and Fish Trade. Edited by Christopher Gerrard and Alejandra Gutiérrez. Oxford University Press, 2018. http://dx.doi.org/10.1093/oxfordhb/9780198744719.013.5.

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This article discusses major developments in British marine (and to a lesser degree freshwater) fishing and fish trade between ad 1050 and 1550. Much information derives from study of fish bones recovered by archaeological excavation. Historical evidence is also important, as is information regarding human diet based on stable isotope analysis of skeletal remains. By combining these sources it is possible to infer the initial growth of marine fishing (especially of herring, cod, and related species), the emergence of long-range fish trade, and the late-medieval reorientation of traditional fis
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13

Glencross, Bonnie. An approach to the palaeoepidemiology of bone fractures: Methods and techniques applied to long bones from the Indian Knoll skeletal sample, Kentucky. 2003.

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14

Yaqoob, Muhammad M. Acidosis in chronic kidney disease. Edited by David J. Goldsmith. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199592548.003.0148.

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Metabolic acidosis becomes increasingly common as chronic kidney disease progresses. It is associated with a number of complications, including bone disease, altered protein synthesis and degradation, skeletal muscle wasting, and lately progressive glomerular filtration rate loss. Experimental and clinical studies suggest a role for alkali therapy to lessen these complications. Recent controlled studies support this notion, and suggest that correction of metabolic acidosis in patients with chronic kidney disease slows the rate of decline of renal function and the development of end-stage renal
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15

Sieper, Joachim. Ankylosing spondylitis. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199642489.003.0113.

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Ankylosing spondylitis (AS) is a chronic inflammatory disease predominantly of the sacroiliac joint (SIJ) and the spine. It starts normally in the second decade of life and has a slight male predominance. The prevalence is between 0.2 and 0.8% and is strongly dependent on the prevalence of HLA B27 in a given population. For the diagnosis of AS, the presence of radiographic sacroiliitis is mandatory. However, radiographs do not detect active inflammation but only structural bony damage. Most recently new classification criteria for axial spondyloarthritis (SpA) have been developed by the Assess
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16

Gray, Andrew C. Orthopaedic approach to the multiply injured patient. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780199550647.003.012003.

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♦ Major trauma results in a systemic stress response proportional to both the degree of initial injury (1st hit) and the subsequent surgical treatment (2nd hit).♦ The key physiological processes of hypoxia, hypovolaemia, metabolic acidosis, fat embolism, coagulation and inflammation operate in synergy during the days after injury/surgery and their effective management determines prognosis.♦ The optimal timing and method of long bone fracture fixation after major trauma remains controversial. Two divergent views exist between definitive early intramedullary fixation and initial external fixatio
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17

Harding, Dennis. Death and Burial in Iron Age Britain. Oxford University Press, 2015. http://dx.doi.org/10.1093/oso/9780199687565.001.0001.

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Archaeologists have long acknowledged the absence of a regular and recurrent burial rite in the British Iron Age, and have looked to rites such as cremation and scattering of remains to explain the minimal impact of funerary practices on the archaeological record. Pit-burials or the deposit of disarticulated bones in settlements have been dismissed as casual disposal or the remains of social outcasts. In Death and Burial in Iron Age Britain, Harding examines the deposition of human and animal remains from the period - from whole skeletons to disarticulated fragments - and challenges the assump
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18

Sieper, Joachim. Axial spondyloarthropathies. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199642489.003.0113_update_003.

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Axial spondyloarthritis (axSpA) is a chronic inflammatory disease predominantly of the sacroiliac joint (SIJ) and the spine. It starts normally in the second decade of life and has a slight male predominance. The prevalence is between 0.2% and 0.8% and is strongly dependent on the prevalence of HLA-B27 in a given population. AxSpA can be split in patients with radiographic axSpA (also termed ankylosing spondylitis (AS)) and in patients with non-radiographic axSpA (nr-axSpA). For the diagnosis of AS, the presence of radiographic sacroiliitis is mandatory. However, radiographs do not detect acti
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19

Abdulkader, Rita, and Richard A. Watts. Mycobacterial diseases. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199642489.003.0103.

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The main diseases caused by mycobacterial infection are tuberculosis (TB) and leprosy. Despite a fall in the prevalence of these diseases over the last decade, they are still significant causes of morbidity and mortality worldwide. Atypical mycobacterial infections are encountered less frequently. Immigration patterns, the frequency of human immunodeficiency infection, and the increased numbers of patients on immunosuppressive treatments render mycobacterial infections relevant not only to physicians in the developing world where they traditionally occurred but also in the developed world. Ske
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