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1

Rao, M. R. S., ed. Long Non Coding RNA Biology. Singapore: Springer Singapore, 2017. http://dx.doi.org/10.1007/978-981-10-5203-3.

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2

Zhang, Lin, and Xiaowen Hu, eds. Long Non-Coding RNAs. New York, NY: Springer US, 2021. http://dx.doi.org/10.1007/978-1-0716-1697-0.

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3

Ugarkovic, Durdica, ed. Long Non-Coding RNAs. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-16502-3.

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4

Feng, Yi, and Lin Zhang, eds. Long Non-Coding RNAs. New York, NY: Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-3378-5.

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5

Chekanova, Julia A., and Hsiao-Lin V. Wang, eds. Plant Long Non-Coding RNAs. New York, NY: Springer New York, 2019. http://dx.doi.org/10.1007/978-1-4939-9045-0.

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6

Navarro, Alfons, ed. Long Non-Coding RNAs in Cancer. New York, NY: Springer US, 2021. http://dx.doi.org/10.1007/978-1-0716-1581-2.

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7

Morris, Kevin V., ed. Long Non-coding RNAs in Human Disease. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-23907-1.

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8

Khalil, Ahmad M., and Jeff Coller, eds. Molecular Biology of Long Non-coding RNAs. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4614-8621-3.

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9

Khalil, Ahmad M., ed. Molecular Biology of Long Non-coding RNAs. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-17086-8.

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10

Cao, Haiming, ed. Functional Analysis of Long Non-Coding RNAs. New York, NY: Springer US, 2021. http://dx.doi.org/10.1007/978-1-0716-1158-6.

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11

Song, Erwei, ed. The Long and Short Non-coding RNAs in Cancer Biology. Singapore: Springer Singapore, 2016. http://dx.doi.org/10.1007/978-981-10-1498-7.

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12

Long Non-coding RNA. Elsevier, 2018. http://dx.doi.org/10.1016/c2017-0-00163-5.

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13

Ugarkovic, Durdica. Long Non-Coding RNAs. Springer, 2011.

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14

Ugarkovic, Durdica. Long Non-Coding RNAs. Springer, 2011.

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15

Ugarkovic, Durdica. Long Non-Coding RNAs. Springer, 2013.

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16

Rao, M. R. S. Long Non Coding RNA Biology. Springer Singapore Pte. Limited, 2017.

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17

Rao, M. R. S. Long Non Coding RNA Biology. Springer, 2018.

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18

Morris, Kevin V. Long Non-Coding RNAs in Human Disease. Springer London, Limited, 2016.

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19

Morris, Kevin V. Long Non-coding RNAs in Human Disease. Springer, 2018.

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20

Morris, Kevin V. Long Non-coding RNAs in Human Disease. Springer, 2016.

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21

Khalil, Ahmad M., and Jeff Coller. Molecular Biology of Long Non-coding RNAs. Springer, 2016.

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22

Khalil, Ahmad M., and Jeff Coller. Molecular Biology of Long Non-Coding RNAs. Springer London, Limited, 2013.

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23

Khalil, Ahmad M. Molecular Biology of Long Non-coding RNAs. Springer, 2019.

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24

Khalil, Ahmad M. Molecular Biology of Long Non-Coding RNAs. Springer International Publishing AG, 2020.

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25

Khalil, Ahmad M., and Jeff Coller. Molecular Biology of Long Non-coding RNAs. Springer, 2013.

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26

Song, Erwei. Long and Short Non-Coding RNAs in Cancer Biology. Springer London, Limited, 2016.

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27

Song, Erwei. Long and Short Non-Coding RNAs in Cancer Biology. Springer Singapore Pte. Limited, 2016.

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28

Chekanova, Julia, and Hsiao-Lin Wang. Plant Long Non-Coding RNAs: Methods and Protocols. Springer New York, 2019.

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29

Morillon, Antonin. Long-Non Coding RNA / the Dark Side of the Genome. Elsevier, 2018.

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30

Song, Erwei. The Long and Short Non-coding RNAs in Cancer Biology. Springer, 2018.

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31

Song, Erwei. The Long and Short Non-coding RNAs in Cancer Biology. Springer, 2016.

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32

Morillon, Antonin. Long Non-Coding RNA: The Dark Side of the Genome. Elsevier, 2018.

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33

Divan, Aysha, and Janice A. Royds. 3. RNA. Oxford University Press, 2016. http://dx.doi.org/10.1093/actrade/9780198723882.003.0003.

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The first RNA molecules to be discovered were those involved in protein synthesis, mRNA, transfer RNA (tRNA), and ribosomal RNA (rRNA). In recent years, a vast number of additional RNA molecules have been identified. ‘RNA’ explains that these are non-coding RNAs that are not involved in protein synthesis, but influence many normal cellular and disease processes by regulating gene expression. RNA interference (RNAi) as one of the main ways in which gene expression is regulated is described with applications to therapy. Classes of RNA, including long non-coding RNAs and catalytic RNAs, are explained along with RNA techniques used to study RNA molecule and gene function.
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34

Long Noncoding Rnas. Springer, 2011.

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35

Reckman, Yolan J., and Yigal M. Pinto. The role of non-coding RNA/microRNAs in cardiac disease. Edited by José Maria Pérez-Pomares, Robert G. Kelly, Maurice van den Hoff, José Luis de la Pompa, David Sedmera, Cristina Basso, and Deborah Henderson. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198757269.003.0031.

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In the past two decades, our knowledge about non-coding DNA has increased tremendously. While non-coding DNA was initially discarded as ‘junk DNA’, we are now aware of the important and often crucial roles of RNA transcripts that do not translate into protein. Non-coding RNAs (ncRNAs) play important functions in normal cellular homeostasis and also in many diseases across all organ systems. Among the different ncRNAs, microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) have been studied the most. In this chapter we discuss the role of miRNAs and lncRNAs in cardiac disease. We present examples of miRNAs with fundamental roles in cardiac development (miR-1), hypertrophy (myomiRs, miR-199, miR-1/133), fibrosis (miR-29, miR-21), myocardial infarction (miR-15, miR17~92), and arrhythmias/conduction (miR-1). We provide examples of lncRNAs related to cardiac hypertrophy (MHRT, CHRF), myocardial infarction (ANRIL, MIAT), and arrhythmias (KCNQ1OT1). We also discuss miRNAs and lncRNAs as potential therapeutic targets or biomarkers in cardiac disease.
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36

Yang, Jin, Pei Han, Wei Li, and Ching-Pin Chang. Epigenetics and post-transcriptional regulation of cardiovascular development. Edited by José Maria Pérez-Pomares, Robert G. Kelly, Maurice van den Hoff, José Luis de la Pompa, David Sedmera, Cristina Basso, and Deborah Henderson. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198757269.003.0032.

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Cardiac organogenesis requires the control of gene expression at distinct developmental windows in order to organize morphogenetic steps in the correct sequence for heart development. This is facilitated by concerted regulation at three levels: chromatin, transcription, and post-transcriptional modifications. Epigenetic regulation at the chromatin level changes the chromatin scaffold of DNA to regulate accessibility of the DNA sequence to transcription factors for genetic activation or repression. At the genome, long non-coding RNAs work with epigenetic factors to alter the chromatin scaffold or form DNA-RNA complexes at specific genomic loci to control the transcription of genetic information. After RNA transcription, the expression of genetic information can be further modified by microRNAs. Each layer of gene regulation requires the participation of many factors, with their combinatorial interactions providing variations of genetic expression at distinct pathophysiological phases of the heart. The major functions of chromatin remodellers and non-coding RNAs are discussed.
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37

Williams, Adam, and Jorge Henao-Mejia, eds. Long Non-Coding RNAs and Immunity. Frontiers Media SA, 2021. http://dx.doi.org/10.3389/978-2-88966-917-2.

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38

Navarro, Alfons. Long Non-Coding RNAs in Cancer. Springer, 2022.

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39

Navarro, Alfons. Long Non-Coding RNAs in Cancer. Springer, 2021.

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40

Long Non-Coding RNAs: Methods and Protocols. Springer New York, 2016.

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41

Feng, Yi, and Lin Zhang. Long Non-Coding RNAs: Methods and Protocols. Springer New York, 2018.

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42

Zhang, Lin, and Xiaowen Hu. Long Non-Coding RNAs: Methods and Protocols. Springer, 2022.

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43

Zhang, Lin, and Xiaowen Hu. Long Non-Coding RNAs: Methods and Protocols. Springer, 2021.

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44

Cao, Haiming. Functional Analysis of Long Non-Coding RNAs: Methods and Protocols. Springer, 2020.

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45

Cao, Haiming. Functional Analysis of Long Non-Coding RNAs: Methods and Protocols. Springer, 2021.

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46

Upadhyay, Santosh Kumar. Long Non-Coding RNAs in Plants: Roles in Development and Stress. Elsevier Science & Technology, 2020.

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47

Upadhyay, Santosh Kumar. Long Non-Coding RNAs in Plants: Roles in Development and Stress. Elsevier Science & Technology Books, 2020.

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