Relevant bibliographies by topics / Long noncoding RNA (lncRNA) / Dissertations / Theses
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Dissertations / Theses on the topic 'Long noncoding RNA (lncRNA)'

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Published: 5 June 2025
Last updated: 15 July 2025

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1

Geisler, Sarah J. "Decapping of Long Noncoding RNAs Regulates Inducible Genes." Case Western Reserve University School of Graduate Studies / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=case1340141951.

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2

Cabili, Nataly Moran. "Integrative Characterization of Human Long Non-Coding RNAs." Thesis, Harvard University, 2014. http://dissertations.umi.com/gsas.harvard:11409.

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Since its early discovery as a messenger, RNA has been shown to play a diverse set of regulatory, structural and even catalytic roles. The more recent understanding that the genome is pervasively transcribed stimulated the discovery of a new prevalent class of long non coding RNAs (lncRNAs). While these are lower abundant and relatively less conserved than other class of functional RNAs, lncRNAs are emerging as key players in different cellular processes in development and disease.
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3

Tuck, Alex Charles. "Genome-wide identification of non-canonical targets of messenger RNA synthesis and turnover factors in Saccharomyces cerevisiae." Thesis, University of Edinburgh, 2013. http://hdl.handle.net/1842/11719.

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Pervasive transcription is widespread amongst eukaryotic genomes, and produces long noncoding RNAs (lncRNAs) in addition to classically annotated transcripts such as messenger RNAs (mRNAs). LncRNAs are heterogeneous in length and map to intergenic regions or overlap with annotated genes. Analogous to mRNAs, lncRNAs are transcribed by RNA polymerase II, regulated by common transcription factors, and possess 5’ caps and perhaps 3’ poly(A) tails. However, lncRNAs perform distinct functions, acting as scaffolds for ribonucleoprotein complexes or directing proteins to nucleic acid targets. The act
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4

TAMENI, ANNALISA. "L'asse lncRNA BlackMamba-DNA elicasi HELLS guida la proliferazione delle cellule ALK-ALCL coordinando un complesso programma oncogenico trascrizionale." Doctoral thesis, Università degli studi di Modena e Reggio Emilia, 2022. http://hdl.handle.net/11380/1278605.

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Nonostante siano stati fatti grandi progressi nella scoperta delle alterazioni genomiche, i meccanismi molecolari alla base della trasformazione del sottotipo di linfoma T anaplastico a grandi cellule ALK- sono stati chiariti solo in parte. Al fine di identificare nuovi driver molecolari in grado di promuovere la progressione dei linfomi anaplastici a grandi cellule (ALCL), è stato messo a punto un RNA-sequencing che ci ha permesso di scoprire 1208 nuovi long noncoding intergenici, includendo tra questi 18 long noncoding principalmente espressi negli ALCL. Per studi molecolari e funzionali la
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Canesin, Lucas Eduardo Costa 1988. "Identificação e caracterização de lncRNAs e genes codificadores linhagem-específicos em Andropogoneae = padrões comuns de evolução de genes emergentes = Identification and characterization lncRNAs and lineage specific coding genes in Andropogoneae : common patterns of evolution of emerging genes." [s.n.], 2014. http://repositorio.unicamp.br/jspui/handle/REPOSIP/317251.

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Orientador: Renato Vicentini dos Santos<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-08-25T20:26:13Z (GMT). No. of bitstreams: 1 Canesin_LucasEduardoCosta_M.pdf: 8460459 bytes, checksum: 3fde4864bd253faed92b7dfd9071be3c (MD5) Previous issue date: 2014<br>Resumo: Recentemente, a análise de dados de genômica comparativa, buscando elucidar melhor a hipótese nula de modelos evolutivos, i.e. evolução neutra, originou uma nova teoria que eleva o tamanho populacional como principal fator evolutivo. Populações pequenas estão
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6

Chan, Jennie. "Dissecting the Role of a lncRNA and Involvement of Plasmodium Infections in the Innate Immune Response: A Dissertation." eScholarship@UMMS, 2015. https://escholarship.umassmed.edu/gsbs_diss/777.

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The innate immune system is a multicomponent response governed by intricate mechanisms of induction, regulation and resolution to elicit antimicrobial defenses. In recent years, the complexity of eukaryotic transcriptomes has become the subject of intense scrutiny and curiosity. It has been established, that RNA polymerase II (RNAPII) transcribes hundreds to thousands of long noncoding RNAs (lncRNAs), often in a stimulus and cell-type specific manner. However, the functional significance of these transcripts has been particularly controversial. While the number of identified lncRNAs is growing
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Chan, Jennie. "Dissecting the Role of a lncRNA and Involvement of Plasmodium Infections in the Innate Immune Response: A Dissertation." eScholarship@UMMS, 2004. http://escholarship.umassmed.edu/gsbs_diss/777.

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The innate immune system is a multicomponent response governed by intricate mechanisms of induction, regulation and resolution to elicit antimicrobial defenses. In recent years, the complexity of eukaryotic transcriptomes has become the subject of intense scrutiny and curiosity. It has been established, that RNA polymerase II (RNAPII) transcribes hundreds to thousands of long noncoding RNAs (lncRNAs), often in a stimulus and cell-type specific manner. However, the functional significance of these transcripts has been particularly controversial. While the number of identified lncRNAs is growing
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8

Bhatta, Ankit. "Role of a Mitochondrial Micropeptide in Regulating Innate Immune Responses." eScholarship@UMMS, 2020. https://escholarship.umassmed.edu/gsbs_diss/1108.

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Short ORF-encoded peptides (SEPs) are increasingly being identified as functional elements in various cellular processes. The current computational methods and experimental molecular biochemistry allow us to discover putative SEPs or micropeptides from proteogenomic datasets and experimentally validate them. Here, we identified a micropeptide produced from a putative long noncoding RNA (lncRNA) 1810058I24Rik which is downregulated in both human and murine myeloid cells exposed to lipopolysaccharide (LPS), as well as other TLR ligands and inflammatory cytokines. Analysis of lncRNA 1810058I24Rik
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9

Bogu, Gireesh K. 1984. "Understanding the transcriptional landscape of non-coding genome in mammals." Doctoral thesis, Universitat Pompeu Fabra, 2017. http://hdl.handle.net/10803/572043.

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Widespread transcription in mammals revealed unexpected discovery of non-coding elements like long noncoding RNAs (lncRNAs) and repetitive elements. First, lncRNAs were previously identified in limited number of tissues or cell lines in mouse and the discovery of lncRNAs was still pending in many other tissues in mouse. To address this, we applied a computational pipeline that discovered 2,803 highconfidence novel lncRNAs by mapping and de novo assembling billions of RNA-Seq reads in eight tissues and a primary cell line in mouse. Further, we integrated this catalog of lncRNAs with chro
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10

Mohammad, Faizaan. "Long Noncoding RNA Mediated Regulation of Imprinted Genes." Doctoral thesis, Uppsala universitet, Institutionen för genetik och patologi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-128882.

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Genomic imprinting is an epigenetic phenomenon that causes a subset of mammalian genes to be expressed from only one allele in a parent-of-origin manner. The defects in the imprinting regulation result in disorders that affect development, growth and metabolism. We have used the Kcnq1 imprinted cluster as a model to understand the mechanism of imprinted gene regulation. The imprinting at the Kcnq1 locus is regulated by a long noncoding RNA, Kcnq1ot1, whose transcription on the paternal chromosome is associated with the silencing of at least eight neighboring genes. By destabilizing Kcnq1ot1 in
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11

Jacob, Mathieu. "Functional Remodelling of the Nucleolus by Long Noncoding RNA." Thesis, Université d'Ottawa / University of Ottawa, 2013. http://hdl.handle.net/10393/30288.

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The nucleolus is a plurifunctional organelle in which structure and function are intimately linked. Though it is primarily known as the site of ribosomal biogenesis, the nucleolus is also capable of orchestrating the immobilization of a broad range of proteins under specific environmental conditions. This process, known as nucleolar sequestration, contributes to cell viability under stress. Despite the importance of this post-translational regulatory pathway, very little is known about the mechanisms that govern it. Here, we show that heat shock and acidosis, two physiological stimuli associat
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12

Keniry, Andrew James. "H19 and miR-675 : a long noncoding RNA conceals a growth suppressing microRNA." Thesis, University of Cambridge, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609990.

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13

Lagarde, Julien. "Genomic Characterization of Human Long Noncoding RNAs." Doctoral thesis, Universitat de Barcelona, 2020. http://hdl.handle.net/10803/668687.

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The human genome contains an astonishingly large fraction of noncoding DNA, which is pervasively transcribed into thousands of long noncoding RNAs (lncRNAs) -- long transcripts with no discernible protein-coding potential. However, little is known about lncRNAs' biological functions, and their genome annotations show evident signs of inadequacy: existing gene models are sketchy, and many lncRNAs remain uncatalogued. This annotation incompleteness hampers lncRNA functional characterization, notably by failing to accurately describe gene boundaries. To address this issue, the present work aims t
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Ballantyne, Margaret. "Understanding the role of long non-coding RNA (LncRNA) in vascular pathology." Thesis, University of Glasgow, 2017. http://theses.gla.ac.uk/8101/.

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Coronary heart disease is a major cause of morbidity and mortality in the Western society. In the case of severe atherosclerosis, percutaneous intervention and coronary bypass grafting remain the preferred form of surgical treatment. However, the patency of both these treatments is limited and several bypass grafts and stents fail due to neointimal formation and in stent restenosis attributable to the proliferation of VSMCs. The resultant luminal renarrowing may manifest clinically with the return of symptoms such as chest pain or shortness of breath and ultimately requires further surgical in
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15

Yang, Junjie. "The role of H19, a long non-coding RNA in the immune system." Thesis, Sorbonne Paris Cité, 2018. http://www.theses.fr/2018USPCC206/document.

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L'empreinte génomique, une régulation épigénétique unique entraînant une expression génique spécifique aux parents d'origine, est essentielle au développement et à la croissance des mammifères. H19 est un ARN long non codant exprimé en milieu maternel qui est un régulateur central du réseau de gènes à empreinte contrôlant le développement. H19 est exprimé pendant le développement embryonnaire dans de nombreux tissus, y compris toutes les cellules hématopoïétiques. Le rôle de H19 au cours du développement embryonnaire n'a été documenté que pour le placenta où il contrôle la croissance. Le rôle
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16

Thomas, Patrick Brian. "Characterisation of the long noncoding RNA GHSROS in prostate and breast cancer." Thesis, Queensland University of Technology, 2018. https://eprints.qut.edu.au/122967/1/Patrick_Thomas_Thesis.pdf.

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In the past decade, there has been significant progress towards characterising genes in the human genome – an effort which unexpectedly revealed a large number of long noncoding RNAs with important regulatory functions in normal physiology and disease processes such as cancer. This thesis represents the first comprehensive study on the ghrelin receptor long noncoding RNA, GHSROS, in breast and prostate cancer. This work has demonstrated that GHSROS reprograms cancer cells towards a more aggressive and chemoresistant phenotype. GHSROS might represent a useful target for RNA-based therapeutics f
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17

Ard, Ryan Anthony. "Functional long non-coding RNA transcription in Schizosaccharomyces pombe." Thesis, University of Edinburgh, 2016. http://hdl.handle.net/1842/20396.

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Eukaryotic genomes are pervasively transcribed and frequently generate long noncoding RNAs (lncRNAs). However, most lncRNAs remain uncharacterized. In this work, a set of positionally conserved intergenic lncRNAs in the fission yeast Schizosaccharomyces pombe genome are selected for further analysis. Deleting one of these lncRNA genes (ncRNA.1343) exhibited a clear phenotype: increased drug sensitivity. Further analyses revealed that deleting ncRNA.1343 also disrupted a previously unannotated lncRNA, termed nc-tgp1, transcribed in the opposite orientation of the predicted ncRNA.1343 gene and i
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18

Pandey, Radha Raman. "Molecular Insights into Kcnq1ot1 Noncoding Antisense RNA Mediated Long Range Transcriptional Gene Silencing." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Universitetsbiblioteket [distributör], 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-9392.

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19

Häfner, Sophia Julia. "Study of X-inactivation independent functions of the conserved long noncoding RNA Ftx." Paris 7, 2014. http://www.theses.fr/2014PA077015.

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Mon travail de thèse se focalise sur l'étude du 1ARNnc Ftx, dont le gène est situé dans le centre d'inactivation du chromosome X , région riche en gènes codant pour des IARNncs et responsable du processus d'inactivation du chromosome X chez les mammifères femelles. Le laboratoire a montré que l'expression de Ftx favorise l'expression des gènes voisins, lui conférant ainsi un rôle activateur dans le processus d'inactivation. Ftx est également exprimé dans l'organisme murin adulte, plus spécifiquement dans le cerveau, suggérant ainsi des fonctions indépendantes du processus d'inactivation. Ainsi
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20

Glover, Anthony Robert. "THE ROLE OF NONCODING RNAS IN THE PATHOGENESIS OF ADRENOCORTICAL CARCINOMA." Thesis, The University of Sydney, 2015. http://hdl.handle.net/2123/14865.

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Adrenocortical cancer (ACC) has a poor prognosis and limited treatments. Noncoding RNAs are important regulators of gene expression and can function as oncogenes or tumour suppressors. Two classes of noncoding RNAs are microRNAs (miRNAs) and long noncoding RNAs (lncRNAs). Aims: To establish lncRNA expression profiles of adrenocortical tumours and evaluate if lncRNA expression can be used to predict clinical outcomes. To evaluate whether the lncRNA - PRINS has a tumour suppressor role in ACC. To investigate miR-7 as a tumour suppressor in ACC in vitro and assess miR-7 replacement as a therapeut
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21

CAO, YU. "Role of lncRNA in cancer development and progression." OpenSIUC, 2017. https://opensiuc.lib.siu.edu/dissertations/1429.

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PART1, TITLE: A p53-inducible long non-coding RNA PICART1 mediating cancer cell proliferation and migration. Long non-coding RNAs (lncRNAs) function in the development and progression of cancer, but only a small portion of lncRNAs are characterized thus far. A novel lncRNA transcript with 2.53 kb in length was identified by a transcriptome sequencing analysis, named p53-inducible cancer-associated RNA transcript 1 (PICART1). This PICART1 is upregulated by p53 through a p53-binding site at -1808 to -1783bp. In breast and colorectal cancer cells and tissues, PICART1 expression was decreased. Ect
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22

Broadbent, Kate Mariel. "The regulatory capacity of long non-coding RNA in Plasmodium falciparum malaria." Thesis, Harvard University, 2014. http://nrs.harvard.edu/urn-3:HUL.InstRepos:13065005.

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The mechanisms underpinning gene regulation in P. falciparum malaria remain largely elusive, though mounting evidence suggests a major role for epigenetic feedback. Interestingly, long non-(protein)-coding RNAs (lncRNAs) have been found to play a dominant role in initiating and guiding the transcriptional, epigenetic, and post-transcriptional status of specific loci across a broad range of organisms. LncRNAs are uniquely poised to act co-transcriptionally on neighboring loci, and/or to remain physically tethered at their site of origin, and through sequence-specific binding activities can impa
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Huo, Xiaoqi. "Understanding the role of long noncoding RNA Taurine Upregulated Gene 1 (TUG1) in hepatocellular carcinoma." Thesis, The University of Sydney, 2021. https://hdl.handle.net/2123/27401.

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Liver cancer is one of the most common and most lethal malignancies that threatens human wellbeing globally. Hepatocellular carcinoma (HCC) is the predominant type of primary liver cancer representing over 70% of all cases. Liver cancer has very disappointing prognosis owing to multiple reasons including the lack of reliable biomarker for early detection, lack of effective treatments, and resistance to the existing drugs. Liver cancer is a highly heterogenous cancer that is regulated at the molecular level by numerous genes and their networks. Long noncoding RNAs (lncRNAs) are RNAs of more
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24

Tan, Jennifer Yihong. "Intergenic long noncoding RNAs provide a novel layer of post-transcriptional regulation in development and disease." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:708df26b-6e5b-4f6f-a0d7-6e3c8b1466ee.

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Recent genome-wide sequencing projects revealed the pervasive transcription of intergenic long noncoding RNAs (lincRNAs) in eukaryotic genomes (reviewed in Ponting et al. 2009). For the vast majority of lincRNAs, their mechanisms of function remain largely unrecognized. However, the genome-wide signatures of functionality associated with many lincRNAs, including apparent evolutionary sequence conservation, spatial and temporal-restricted expression patterns, strong associations with epigenetic marks, and reported molecular and cellular functions, reinforce their biological relevance. My work i
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Dixon, Maria S. "ANTISENSE AFP TRANSCRIPTS IN MOUSE LIVER AND THEIR POTENTIAL ROLE IN AFP GENE REGULATION." UKnowledge, 2017. http://uknowledge.uky.edu/microbio_etds/14.

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Hepatocellular carcinoma (HCC) is the most common form of primary liver cancer, ranking the sixth most common cancer and third most common cause of cancer mortality worldwide. Alpha-fetoprotein (AFP) is a plasma protein that is highly expressed in the fetal liver and shut off after birth. AFP expression is elevated in regenerating adult liver and HCC and has been used extensively as a diagnostic marker of liver cancer. We have been studying mouse liver gene regulation to better understand mechanisms by which changes in gene expression contribute to liver development, homeostasis and disease. Z
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26

Romero, barrios Natali. "Non-codings RNAs, regulators of gene expression in Arabidopsis thaliana root developmental plasticity Noncoding Transcription by Alternative RNA Polymerases Dynamically Regulates an Auxin-Driven Chromatin Loop Battles and hijacks: noncoding transcription in plants Long noncoding RNA modulates alternative splicing regulators in Arabidopsis Detection of generic differential RNA processing events from RNA-seq data." Thesis, Université Paris-Saclay (ComUE), 2016. http://www.theses.fr/2016SACLS128.

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Les techniques de séquençage à haut-débit développées ces dernières années ont permis d'identifier des milliers d’ARN non-codants et des événements tels que l’épissage ou l’édition. Cette approche est à l’origine d’une meilleure compréhension des mécanismes régulant l'expression des gènes. Les longs ARN non-codants (lncARN) ont ainsi émergé comme des acteurs clés de la régulation de divers processus développementaux. Ils agissent soit directement sous leur forme longue par des interactions lncARN-protéine(s) soit après une étape de maturation qui génère des siARN ou des miARN régulateurs, mena
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Sohiya, Yotsukura. "Computational Framework for the Dissection of Cancer Genomic Architecture and its Association in Different Biomarkers." 京都大学 (Kyoto University), 2016. http://hdl.handle.net/2433/217149.

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28

Karlsson, Joakim. "Differential and co-expression of long non-coding RNAs in abdominal aortic aneurysm." Thesis, Uppsala universitet, Institutionen för biologisk grundutbildning, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-236141.

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This project concerns an exploration of the presence and interactions of long non-coding RNA transcripts in an experimental atherosclerosis mouse model with relevance for human abdominal aortic aneurysm development. 187 long noncoding RNAs, two of them entirely novel, were found to be differentially expressed between angiotensin II treated (developing abdominal aortic aneurysms) and non-treated apolipoprotein E deficient mice (not developing aneurysms) harvested after the same period of time. These transcripts were also studied with regards to co-expression network connections. Eleven previous
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Chehade, Marthe. "Thre Long Noncoding RNA PRINS in Endocrine Cancer: Evaluating its Clinical Significance and the Evidence for its Functional Role." Thesis, The University of Sydney, 2022. https://hdl.handle.net/2123/29641.

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Adrenocortical carcinoma (ACC) and breast cancer are endocrine malignancies with poor prognosis in advanced disease. Long non-coding RNA (lncRNA) have varied roles in the regulation of gene expression and can act as oncogenes and tumour suppressors. Psoriasis-susceptibility associated RNA gene induced by stress (PRINS) is a lncRNA that is under-expressed in ACC tissues in a tumour suppressor pattern and predicts disease recurrence. This thesis aims to evaluate the potential of PRINS as a tumour suppressor in various ACC and breast cancer in-vitro gain-of-function (GoF) models, and explore t
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Abo, Khayal Layal. "Transkriptomická charakterizace pomocí analýzy RNA-Seq dat." Doctoral thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2018. http://www.nusl.cz/ntk/nusl-369382.

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Vysoce výkonné sekvenční technologie produkují obrovské množství dat, která mohou odhalit nové geny, identifikovat splice varianty a kvantifikovat genovou expresi v celém genomu. Objem a složitost dat z RNA-seq experimentů vyžadují škálovatelné metody matematické analýzy založené na robustníchstatistických modelech. Je náročné navrhnout integrované pracovní postupy, které zahrnují různé postupy analýzy. Konkrétně jsou to srovnávací testy transkriptů, které jsou komplikovány několika zdroji variability měření a představují řadu statistických problémů. V tomto výzkumu byla sestavena integrovaná
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Hu, Haiyang [Verfasser]. "Computational and Statistical Analysis of Sequence and Expression Features of MicroRNA and Long Noncoding RNA in Primate Brains / Haiyang Hu." Berlin : Freie Universität Berlin, 2016. http://d-nb.info/1093404175/34.

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ROSSI, MARTINA. "Long Noncoding RNA “EPR” controls epithelial cell proliferation by coordinating CDKN1A transcription and mRNA decay in response to TGF-β". Doctoral thesis, Università degli studi di Genova, 2019. http://hdl.handle.net/11567/936734.

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Long noncoding RNAs (lncRNAs) are emerging as regulators of fundamental biological processes. Here we report on the functional characterization of an intergenic lncRNA (lincRNA) expressed in epithelial tissues which we termed EPR (Epithelial cell Program Regulator). EPR is rapidly downregulated by TGF-β and its sustained expression largely reshapes the transcriptome, favors the acquisition of epithelial traits, and reduces cell proliferation in cultured mammary gland cells as well as in an animal model of orthotopic transplantation. EPR generates a small peptide that localizes at epithelial ce
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Smith, Jenna E. "Investigation of the mRNP and Transcriptome Regulated by Nonsense-Mediated RNA Decay." Case Western Reserve University School of Graduate Studies / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=case1421428941.

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Xie, Bingning. "Long non-coding RNA-based mechanisms for the inhibition of cell growth and development by 5 - Fluorouracil." Thesis, Rennes 1, 2016. http://www.theses.fr/2016REN1B046/document.

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Les ARNm codent pour les protéines, tandis qu'un grand nombre d'ARNs nommés longues ARNs non codants (ARNlnc) ne sont pas traduites en protéines. Les deux types d’ARNs existent en isoforms qui se distinguent à cause de l’épissage alternatif. Certains des ARNlnc jouent des rôles importants dans la croissance et différentiation cellulaire. Cependant, leurs fonctions dans la cytotoxicité de la chimiothérapie anti-cancéreuse médicamenteuse utilisant le 5-fluorouracile (5-FU) sont encore inconnues. Pendant mes travaux j'ai trouvé que le traitement par le 5-FU cause l’accumulation des ARNlnc. Ce phé
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Oldoni, E. "THE ROLE OF CELLULAR AND EXOSOMAL NEURAL-DERIVED LONG NON CODING RNA (LNCRNA) IN MULTIPLE SCLEROSIS: POTENTIAL BIOMARKERS OF DISEASE SUSCEPTIBILITY AND PROGRESSION." Doctoral thesis, Università degli Studi di Milano, 2018. http://hdl.handle.net/2434/540356.

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Long non-coding RNAs (lncRNAs) are a novel class of transcripts that are pervasively transcribed in the genome. Several lines of evidence correlate dysregulation of different lncRNAs to human diseases including neurological and autoimmune disorders, but their expression has not been exhaustively investigated in MS so far. The main aim of this study was to identify a specific signature of cellular and neural-derived exosomal lncRNA expression. Regarding lncRNA expression levels from Peripheral Blood Mononuclear Cells (PBMC), we studied a discovery cohort of MS patients who were compared agai
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Sutaria, Dhruvitkumar S. "INVESTIGATION OF DIFFERENTIALLY EXPRESSED NONCODING RNAS IN PANCREATIC DUCTAL ADENOCARCINOMA." The Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1480550158159039.

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37

De, Clara Etienne. "Etude des longs ARNs non codants dans la leucémie aiguë myéloblastique à caryotype normal." Thesis, Toulouse 3, 2015. http://www.theses.fr/2015TOU30280/document.

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Les longs ARN non codants (lncRNAs) sont définis comme des transcrits de plus de 200nt et n'ayant pas de potentiel codant. Des études récentes ont démontré que les lncRNAs pouvaient être impliqués dans la régulation de la transcription, de la traduction, de la différenciation cellulaire, de l'expression génique, du cycle cellulaire et des modifications de la chromatine. De plus, il a été montré un impact fonctionnel de certains lncRNAs dans le processus de cancérogenèse mais nos connaissances actuelles sur ces molécules dans le cancer, et plus particulièrement dans la leucémie, restent extrême
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Pereira, Carlos de Ocesano. "INXS, um longo RNA não codificador de proteínas mediador da apoptose." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/46/46131/tde-20072015-144251/.

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O splicing alternativo do pré-mRNA de BCL-X produz duas isoformas de mRNAs com funções antagônicas, a pró-apoptótica BCL-XS e a anti-apoptótica BCL-XL, cujo balanço regula a homeostasia celular. Entretanto, o mecanismo que regula esse processamento ainda é desconhecido. Nesse trabalho, nós identificamos e caracterizamos um longo RNA não codificador de proteínas (lncRNA) nomeado INXS, que é transcrito a partir da fita oposta do locus genômico de BCL-X, sendo menos abundante em linhagens celulares tumorais e tecidos tumorais de pacientes quando comparados com os respectivos pares não tumorais. I
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Hofmann, Patrick [Verfasser], Reinier [Akademischer Betreuer] Boon, Stefanie [Gutachter] Dimmeler, and Amparo [Gutachter] Acker-Palmer. "The long noncoding RNA H19 controls endothelial cell functions by STAT3 repression / Patrick Hofmann ; Gutachter: Stefanie Dimmeler, Amparo Acker-Palmer ; Betreuer: Reinier Boon." Frankfurt am Main : Universitätsbibliothek Johann Christian Senckenberg, 2018. http://d-nb.info/1153572389/34.

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40

Haller, Alexandre. "Characterization of long non-coding RNA LENT, a potential therapeutic target in cutaneous melanoma." Electronic Thesis or Diss., Strasbourg, 2024. http://www.theses.fr/2024STRAJ025.

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Le mélanome est le plus agressif des cancers de la peau, représentant 1 % des cancers cutanés mais responsable de la plupart des décès liés à ces cancers. Les mélanomes métastatiques sont traités par immunothérapie ou par une inhibition ciblée de MAPK. Néanmoins, la résistance primaire ou acquise met les chercheurs au défi de trouver de nouvelles thérapies. Dans ce contexte, le laboratoire d’accueil a identifié une série de longs ARNs non-codants (LncRNA) spécifiques du mélanome. Mon projet concerne le lncRNA LENT (LncRNA Enhancer of Translation) fortement exprimé dans les mélanomes par rappor
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41

Tsuji, Shuhei. "Lionheart LincRNA alleviates cardiac systolic dysfunction under pressure overload." Doctoral thesis, Kyoto University, 2021. http://hdl.handle.net/2433/263521.

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42

Beckedorff, Felipe César Ferrarezi. "Recrutamento do complexo repressivo polycomb 2 pelo RNA não codificador longo antissenso ANRASSF1 modula a expressão do gene RASSF1A e a proliferação celular." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/46/46131/tde-23042013-083641/.

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O gene supressor tumoral RASSF1A tem sido associado com redução da proliferação celular em diversos tumores. Sua expressão é regulada por eventos epigenéticos que envolvem o complexo repressivo polycomb (PRC2), no entanto os mecanismos moleculares da modulação do recrutamento deste modificador epigenético para este locus ainda são desconhecidos. Neste trabalho identificamos e caracterizamos ANRASSF1, um RNA não codificador longo (lncRNA) intrônico unspliced, que é transcrito na fita oposta do gene RASSF1A, em várias linhagem celulares e tecidos, e se liga a PRC2. ANRASSF1 é transcrito pela RNA
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43

Pettini, Tom. "The role of novel long non-coding RNAs in Hox gene regulation." Thesis, University of Manchester, 2013. https://www.research.manchester.ac.uk/portal/en/theses/the-role-of-novel-long-noncoding-rnas-in-hox-gene-regulation(c8e44900-3ac0-40be-8ec6-b50179381d17).html.

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Whole genome transcriptome analysis has revealed that a large proportion of the genome in higher metazoa is transcribed, yet only a small proportion of this transcription is protein-coding. One possible function of non-coding transcription is that it enables complex and diverse body plans to evolve through variation in deployment of a relatively common set of protein-coding genes. Functional studies suggest that long non-coding RNAs (lncRNAs) regulate gene expression via diverse mechanisms, operating in both cis and trans to activate or repress target genes. An emerging theme common to lncRNA
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Schmidt, Elena [Verfasser], Jan-Wilhelm [Gutachter] Kornfeld, Thorsten [Gutachter] Hoppe, and Lei [Gutachter] Sun. "Long noncoding RNA H19 protects from dietary obesity by promoting brown adipose tissue commitment and function / Elena Schmidt ; Gutachter: Jan-Wilhelm Kornfeld, Thorsten Hoppe, Lei Sun." Köln : Universitäts- und Stadtbibliothek Köln, 2018. http://d-nb.info/1172414653/34.

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45

Joshi, Parth Devesh [Verfasser], Gregor [Akademischer Betreuer] Eichele, Reinhard [Gutachter] Lührmann, and Ernst A. [Gutachter] Wimmer. "Molecular characterization and functional analysis of a novel long noncoding RNA in the mouse / Parth Devesh Joshi ; Gutachter: Reinhard Lührmann, Ernst A. Wimmer ; Betreuer: Gregor Eichele." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2019. http://d-nb.info/1187520225/34.

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46

Zaniboni, Gabriel Francisco. "Implementação de abordagens computacionais para identificação de RNAs longos não codificadores envolvidos na diferenciação neural." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/95/95131/tde-02022016-150323/.

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Cada vez mais, RNAs longos não codificadores (lncRNAs) surgem como importantes reguladores da biologia celular, principalmente em processos de diferenciação durante o desenvolvimento. O interesse no estudo das funções e mecanismos de atuação dessa classe de transcritos durante esses processos é crescente, e mostra-se bastante relevante no processo de diferenciação neural, pelo qual são gerados neurônios e células da glia. A linhagem celular P19, uma célula pluripotente advinda de um tipo de carcinoma embrionário murino, é bem consolidada como modelo in vitro de diferenciação neural. Após trata
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47

Coyne, Victoria. "Characterization of long non-coding RNAs in the Hox complex of Drosophila." Thesis, University of Manchester, 2017. https://www.research.manchester.ac.uk/portal/en/theses/characterization-of-long-noncoding-rnas-in-the-hox-complex-of-drosophila(733e3dec-3f7b-4d6e-a1bc-674a8786246d).html.

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Long non-coding RNAs (lncRNAs) are often defined as transcripts >200nts that have no discernable protein-coding ability (Quinn and Chang, 2016). Although relatively little is understood about the molecular mechanisms of lncRNA function, they have established roles in regulation of gene expression during development, cell differentiation and pluripotency (Fatica and Bozzoni, 2014; Luo et al., 2016; Quinn and Chang, 2016; Rinn and Chang, 2012) across vastly diverse organisms ranging from plants to humans (Ulitsky and Bartel, 2013). LncRNAs have also been associated with numerous pathological con
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48

Jarroux, Julien. "Caractérisation fonctionnelle des longs ARN non codants associés à la transition épithélio-mésenchymateuse." Electronic Thesis or Diss., Paris Sciences et Lettres (ComUE), 2019. https://theses.hal.science/tel-02882448.

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Depuis dix ans, les techniques de séquençage haut-débit ont montré l’incroyable complexité du transcriptome humain, révélant une nouvelle classe d’ARN : les longs ARN non codants (lncARN). Depuis, leur expression a été démontré comme spécifique au type cellulaire ou aux variations pathologiques, et c’est notamment le cas du cancer où ils sont fortement dérégulés. Cependant, les mécanismes par lesquelles ils agissent dans le développement tumoral restent peu caractérisés. Aussi, ce projet vise à faire une caractérisation fonctionnelle des lncARN dans la transition épithélio-mésenchymateuse (TEM
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49

Junetha, Syed Jabarulla. "Chemical Biology Approaches for Regulating Eukaryotic Gene Expression." 京都大学 (Kyoto University), 2015. http://hdl.handle.net/2433/202664.

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Nowicki-Osuch, Karol Piotr. "Identification and characterisation of long non-coding RNAs expressed downstream of EGF-induced signalling programme." Thesis, University of Manchester, 2016. https://www.research.manchester.ac.uk/portal/en/theses/identification-and-characterisation-of-long-noncoding-rnas-expressed-downstream-of-egfinduced-signalling-programme(fd52d235-1a50-4347-bdb1-fdba4fdb912d).html.

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It has recently become apparent that cells encode a large number of novel non-protein-coding genes called long non-coding RNAs (lncRNAs). Whilst the biological function of many lncRNAs remains unknown, recent evidence has suggested that lncRNAs may be important regulators of cellular growth, differentiation and may play a significant role in cancer. Epidermal growth factor (EGF) – an activator of the ERK1/2 signalling cascade – is an important spatio-temporal regulator of transcription and, ultimately, of cellular growth and movement. EGF stimulation triggers a wave-like expression of immediat
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